1,483 results match your criteria Burns Ocular


Novel window for cancer nanotheranostics: non-invasive ocular assessments of tumor growth and nanotherapeutic treatment efficacy .

Biomed Opt Express 2019 Jan 11;10(1):151-166. Epub 2018 Dec 11.

EyePod Small Animal Ocular Imaging Laboratory, University of California, Davis, CA 95616, USA.

In cancer research there is a fundamental need for animal models that allow the longitudinal visualization and quantification of tumor development, nanotherapeutic delivery, the tumor microenvironment including blood vessels, macrophages, fibroblasts, immune cells, and extracellular matrix, and the tissue response to treatment. To address this need, we developed a novel mouse ocular xenograft model. Green fluorescent protein (GFP) expressing human glioblastoma cells (between 500 and 10,000) were implanted into the subretinal space of immunodeficient mice (56 eyes). Read More

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http://dx.doi.org/10.1364/BOE.10.000151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363190PMC
January 2019

Philadelphia Telemedicine Glaucoma Detection and Follow-up Study: confirmation between eye screening and comprehensive eye examination diagnoses.

Br J Ophthalmol 2019 Feb 15. Epub 2019 Feb 15.

Glaucoma Service, Wills Eye Hospital, Philadelphia, Pennsylvania, USA.

Aims: To evaluate agreement between ocular findings of a telemedicine eye screening (visit 1) with diagnoses of a comprehensive eye examination (visit 2).

Methods: A primary care practice (PCP)-based telemedicine screening programme incorporating fundus photography, intraocular pressure (IOP) and clinical information was conducted. Eligible individuals were African American, Hispanic/Latino or Asian over the age of 40; Caucasian individuals over age 65; and adults of any ethnicity over age 40 with a family history of glaucoma or diabetes. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313451DOI Listing
February 2019
2 Reads

Staged ocular fornix reconstruction for glaucoma drainage device under neoconjunctiva at the time of Boston type 1 Keratoprosthesis implantation.

Ocul Surf 2019 Feb 8. Epub 2019 Feb 8.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, United States.

Purpose: Glaucoma is the leading cause of vision loss in eyes with Boston Keratoprosthesis (KPro). Glaucoma drainage devices (GDDs) have been shown to be effective in controlling glaucoma with KPro. Cicatricial conjunctival disease with forniceal shortening is a major challenge and limitation to the use of GDD. Read More

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http://dx.doi.org/10.1016/j.jtos.2019.01.010DOI Listing
February 2019
1 Read

The clinical toxicology of sodium hypochlorite.

Clin Toxicol (Phila) 2019 Jan 28:1-9. Epub 2019 Jan 28.

a National Poisons Centre , University of Otago , Dunedin , New Zealand.

Introduction: Sodium hypochlorite is used as a bleaching and disinfecting agent and is commonly found in household bleach.

Objective: The objective is to review critically the epidemiology, mechanisms of toxicity, clinical features, diagnosis, and management of hypochlorite poisoning.

Methods: PubMed was searched from January 1950 to June 2018 using the terms "Hypochlorite", "Sodium Hypochlorite", "Sodium Oxychloride", "Hypochlorous Acid", "Bleach", "Chlorine Bleach", in combination with the keywords "poisoning", "poison", "toxicity", "ingestion", "adverse effects", "overdose", and "intoxication". Read More

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http://dx.doi.org/10.1080/15563650.2018.1543889DOI Listing
January 2019
1 Read

Matriderm and Split Skin Grafting for Full-Thickness Pediatric Facial Burns.

J Burn Care Res 2019 Feb;40(2):251-254

The Children's Hospital at Westmead, Westmead, New South Wales, Australia.

Facial burns remain a complex reconstructive challenge. Achieving the plastic surgical goals of restoring form and function is difficult in these cases, with poor cosmetic results, reduced facial animation, and oral and ocular contractures a common result. In recent years, the use of dermal substitutes in combination with skin grafts has shown promising results in complex burn reconstruction. Read More

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http://dx.doi.org/10.1093/jbcr/irz006DOI Listing
February 2019

Corneal Wound Healing Effects of Mesenchymal Stem Cell Secretome Delivered Within a Viscoelastic Gel Carrier.

Stem Cells Transl Med 2019 Jan 15. Epub 2019 Jan 15.

Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, California, USA.

Severe corneal injuries often result in permanent vision loss and remain a clinical challenge. Human bone marrow derived mesenchymal stem cells (MSCs) and their secreted factors (secretome) have been studied for their antiscarring, anti-inflammatory, and antiangiogeneic properties. We aimed to deliver lyophilized MSC secretome (MSC-S) within a viscoelastic gel composed of hyaluronic acid (HA) and chondroitin sulfate (CS) as a way to enhance corneal re-epithelialization and reduce complications after mechanical and chemical injuries of the cornea. Read More

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http://doi.wiley.com/10.1002/sctm.18-0178
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http://dx.doi.org/10.1002/sctm.18-0178DOI Listing
January 2019
3 Reads

Scleral Ischemia in Acute Ocular Chemical Injury: Long-Term Impact on Rehabilitation With Limbal Stem Cell Therapy.

Cornea 2019 Feb;38(2):198-202

Dr. Shroff's Charity Eye Hospital, Daryaganj, New Delhi, India.

Purpose: This study describes the impact of scleral ischemia on globe survival in cases of acute chemical injury and the outcome of limbal stem cell transplant in these eyes.

Methods: This is a single-center, retrospective case study that reviews outcomes in all patients with acute chemical injury of grades IV and above who presented within 6 weeks from injury. The period of the study is between May 2012 and May 2017. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001807DOI Listing
February 2019
2 Reads

Commentary: Assessment of limbal ischemia in ocular burns.

Indian J Ophthalmol 2019 Jan;67(1):37

Department of Cornea and Refractive Services, Aravind Eye Hospital, Madurai, Tamil Nadu, India.

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http://dx.doi.org/10.4103/ijo.IJO_1432_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324105PMC
January 2019

Limbal ischemia: Reliability of clinical assessment and implications in the management of ocular burns.

Indian J Ophthalmol 2019 Jan;67(1):32-36

Brien Holden Eye Research Center, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, Telangana, India.

Purpose: Limbal ischemia is an important prognostic factor in the management of ocular burns. In this study, we evaluated the reliability of clinically assessing limbal ischemia among ophthalmic professionals.

Methods: This study included 111 ophthalmic professionals who were shown 12 diffuse illumination color slit-lamp photographs of eyes with recent chemical injuries. Read More

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http://www.ijo.in/text.asp?2019/67/1/32/243760
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http://dx.doi.org/10.4103/ijo.IJO_945_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324115PMC
January 2019
13 Reads

Monocyte infiltration rather than microglia proliferation dominates the early immune response to rapid photoreceptor degeneration.

J Neuroinflammation 2018 Dec 15;15(1):344. Epub 2018 Dec 15.

Department of Cell Biology and Human Anatomy, University of California, Davis, 1 Shields Avenue, Davis, CA, 95616, USA.

Background: Activation of resident microglia accompanies every known form of neurodegeneration, but the involvement of peripheral monocytes that extravasate and rapidly transform into microglia-like macrophages within the central nervous system during degeneration is far less clear.

Methods: Using a combination of in vivo ocular imaging, flow cytometry, and immunohistochemistry, we investigated the response of infiltrating cells in a light-inducible mouse model of photoreceptor degeneration.

Results: Within 24 h, resident microglia became activated and began migrating to the site of degeneration. Read More

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http://dx.doi.org/10.1186/s12974-018-1365-4DOI Listing
December 2018

Ocular Considerations in Face Transplantation: Report of 2 Cases and Review of the Literature.

Ophthalmic Plast Reconstr Surg 2018 Dec 7. Epub 2018 Dec 7.

The Hansjörg Wyss Department of Plastic Surgery and.

Purpose: Periorbital injuries are common in face transplantation (FT) candidates. It is therefore essential that the ophthalmologist play a central role in the multidisciplinary treatment of these patients. In this study, the authors perform a comprehensive review of all procedures involving periorbital components, provide an update for the ophthalmology community regarding the current state of the field, and present 2 cases. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001296DOI Listing
December 2018
9 Reads

Retinal burns from laser pointers: a risk in children with behavioural problems.

Eye (Lond) 2018 Dec 13. Epub 2018 Dec 13.

Department of Ophthalmology, Bolton Hospitals NHS Foundation Trust, Bolton, UK.

Objective: To explore self-inflicted retinal burns from laser pointers in children.

Methods: Literature review of laser pointer retinal injuries in childhood and online survey of UK Consultant Ophthalmologists. A cohort of local children with self-inflicted injury is described. Read More

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http://dx.doi.org/10.1038/s41433-018-0276-zDOI Listing
December 2018
1 Read

Non-GVHD ocular complications after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT.

Bone Marrow Transplant 2018 Dec 7. Epub 2018 Dec 7.

Department of Ophthalmology, Hospital Universitario Puerta de Hierro, Madrid, Spain.

Non-graft-vs.-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Read More

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http://dx.doi.org/10.1038/s41409-018-0339-6DOI Listing
December 2018
6 Reads

Non-Graft-versus-Host Disease Ocular Complications after Hematopoietic Cell Transplantation: Expert Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society for Blood and Marrow Transplantation.

Biol Blood Marrow Transplant 2018 Dec 3. Epub 2018 Dec 3.

Department of Ophthalmology, Puerta de Hierro Majadahonda University Hospital, Madrid, Spain.

Non-graft-versus-host disease (GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT) but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplantation physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Complications discussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment and ocular toxicities associated with medications. Read More

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http://dx.doi.org/10.1016/j.bbmt.2018.11.033DOI Listing
December 2018
23 Reads

Amniotic membrane transplantation with or without autologous cultivated limbal stem cell transplantation for the management of partial limbal stem cell deficiency.

Clin Ophthalmol 2018 17;12:2103-2106. Epub 2018 Oct 17.

Cornea, Cataract and External Disease Services, Refractive Surgery Service, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA,

Purpose: To compare the outcomes of amniotic membrane transplantation (AMT) vs cultivated limbal stem cell transplantation (LSCT) in eyes with partial limbal stem cell deficiency (LSCD) following chemical burns.

Methods: Eyes with unilateral partial LSCD (#180° involvement) were randomized in two groups to undergo either pannus resection combined with AMT or pannus resection combined with LSCT in a tertiary eye care hospital. Primary outcome measures were time to corneal epithelialization and absence of conjunctivalization of the cornea. Read More

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https://www.dovepress.com/amniotic-membrane-transplantation-
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http://dx.doi.org/10.2147/OPTH.S181035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200088PMC
October 2018
14 Reads

Herpes Simplex Virus 1 ICP22 Suppresses CD80 Expression by Murine Dendritic Cells.

J Virol 2019 Feb 17;93(3). Epub 2019 Jan 17.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns and Allen Research Institute, Los Angeles, California, USA

Herpes simplex virus type 1 (HSV-1) has the ability to delay its clearance from the eye during ocular infection. Here, we show that ocular infection of mice with HSV-1 suppressed expression of the costimulatory molecule CD80 but not CD86 in the cornea. The presence of neutralizing anti-HSV-1 antibodies did not alleviate this suppression. Read More

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http://jvi.asm.org/lookup/doi/10.1128/JVI.01803-18
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http://dx.doi.org/10.1128/JVI.01803-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340034PMC
February 2019
15 Reads

Prospective analysis of pediatric ocular chemical burns: laundry detergent pods.

J AAPOS 2018 Dec 17;22(6):426-428. Epub 2018 Oct 17.

Department of Ophthalmology & Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt University School of Medicine, Nashville, Tennessee.

Purpose: To present data on chemical ocular burns in children seen at a single tertiary care facility resulting from accidental eye exposure to the contents of laundry detergent pods.

Methods: All emergent pediatric ophthalmology consultations specific for chemical ocular burns at a level I trauma center were included as part of a prospective quality improvement investigation over a 13-month period. Age, causative agent, and examination findings at presentation and final follow-up were recorded and analyzed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10918531183054
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http://dx.doi.org/10.1016/j.jaapos.2018.07.349DOI Listing
December 2018
8 Reads

Skin cancer and welding.

Clin Exp Dermatol 2019 Mar 2;44(2):130-134. Epub 2018 Oct 2.

School of Medicine, West Virginia University, Morgantown, WV, USA.

Many workers in several different occupations can be exposed to ultraviolet radiation (UVR), which may increase their risk of developing skin cancer. Welding, an occupation employing an estimated 11 million people worldwide, is one such occupation. Welders are known to be exposed to the full spectrum of UVR from the welding arc and often experience burns and localized cutaneous erythema. Read More

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http://dx.doi.org/10.1111/ced.13783DOI Listing

[Emergency management of chemical eye burns].

Lakartidningen 2018 10 2;115. Epub 2018 Oct 2.

S:t Eriks Ögonsjukhus - sektionen för gråstarr/hornhinna Stockholm, Sweden S:t Eriks Ögonsjukhus - Sektionen för gråstarr/hornhinna Stockholm, Sweden.

Chemical burn injury of the eye is a medical emergency that requires immediate intervention and structured ophthalmic assessment without unnecessary delay. Chemicals, alkali in particular but also acids, cause profound damage to the anatomy of the ocular surface or even deeper eye structures. The injury is potentially sight-threatening and can, in the worst cases, lead to loss of the eye. Read More

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October 2018
16 Reads

Anti-Inflammatory and Anti-Fibrotic Effects of Human Amniotic Membrane Mesenchymal Stem Cells and Their Potential in Corneal Repair.

Stem Cells Transl Med 2018 Dec 10;7(12):906-917. Epub 2018 Sep 10.

Research Unit, Cell and Tissue Biology, Institute of Ophthalmology Conde de Valenciana, Mexico City, Mexico.

Acute ocular chemical burns are ophthalmic emergencies requiring immediate diagnosis and treatment as they may lead to permanent impairment of vision. The clinical manifestations of such burns are produced by exacerbated innate immune response via the infiltration of inflammatory cells and activation of stromal fibroblasts. New therapies are emerging that are dedicated to repair mechanisms that improve the ocular surface after damage; for example, transplantation of stem cells (SC) has been successfully reported for this purpose. Read More

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http://doi.wiley.com/10.1002/sctm.18-0042
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http://dx.doi.org/10.1002/sctm.18-0042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265633PMC
December 2018
6 Reads

Ocular chemical burns from accidental exposure to topical dermatological medicinal agent.

Indian J Ophthalmol 2018 Oct;66(10):1476-1477

Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

We report a case of accidental ocular chemical injury by self-medication with a single application of a topical ayurvedic medication containing salicylic acid, phenol, and tincture iodine, which is being used in developing countries for treatment of various dermatological conditions. Read More

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http://www.ijo.in/text.asp?2018/66/10/1476/242010
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http://dx.doi.org/10.4103/ijo.IJO_365_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173047PMC
October 2018
4 Reads
0.930 Impact Factor

Tractional Descemet's membrane detachment after ocular alkali burns: case reports and review of literature.

BMC Ophthalmol 2018 Sep 24;18(1):256. Epub 2018 Sep 24.

Joint Shantou International Eye Center, Shantou University & the Chinese University of Hong Kong, Shantou, China.

Background: Descemet's membrane detachment (DMD) is a rare complication after ocular chemical injury and its pathogenesis remains unclear. In this study, we reported two cases of DMD with traction demonstrated on Anterior segment optical coherence tomography (AS-OCT).

Case Presentation: Two patients sustained ocular chemical injury with 50% sodium hydroxide. Read More

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http://dx.doi.org/10.1186/s12886-018-0924-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154944PMC
September 2018
3 Reads

CLEARED (Chemicals and Litmus testing with Effective Alkaline Range for Eye Damage): A Prospective, Interventional Study.

Acad Emerg Med 2018 Sep 24. Epub 2018 Sep 24.

Department of Ophthalmology & Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN.

Objectives: While immediate diagnosis and irrigation is standard chemical eye burn practice, it is unknown to what extent specific pH measurements influence management, given the frequent clinical availability of narrow-spectrum nitrazine pH strips. We hypothesize that exclusive broad-spectrum pH strip implementation leads to more accurate measurement and expedited ophthalmologic consultation.

Methods: At a Level I trauma center over 25 months, all emergent adult ophthalmology consultations for chemical burns were included in a pre-intervention (n = 22) and post-intervention (n = 20) study design. Read More

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http://dx.doi.org/10.1111/acem.13622DOI Listing
September 2018
1 Read

Acute Chemical Eye Injury and Limbal Stem Cell Deficiency-A Prospective Study in the United Kingdom.

Cornea 2019 Jan;38(1):8-12

Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.

Purpose: To analyze the incidence, nature, outcomes, and complications of acute chemical eye injuries, including the incidence of limbal stem cell deficiency (LSCD) and to compare the 2 main classifications for ocular chemical injuries: Roper-Hall (RH) and Dua.

Methods: This is a prospective, consecutive, interventional single-center study between April and October 2009 of all new patients with acute chemical eye injury presenting to the Royal Victoria Infirmary eye emergency department (EED).

Results: Of 11,683 patients who attended the EED, 98 patients (110 eyes) presented with acute chemical eye injury (60% male). Read More

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http://Insights.ovid.com/crossref?an=00003226-900000000-9676
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http://dx.doi.org/10.1097/ICO.0000000000001739DOI Listing
January 2019
7 Reads

Nanostructured lipid carriers containing rapamycin for prevention of corneal fibroblasts proliferation and haze propagation after burn injuries: In vitro and in vivo.

J Cell Physiol 2019 Apr 7;234(4):4702-4712. Epub 2018 Sep 7.

Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Chemical burns are a major cause of corneal haze and blindness. Corticosteroids are commonly used after corneal burns to attenuate the severity of the inflammation-related fibrosis. While research efforts have been aimed toward application of novel therapeutics. Read More

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http://dx.doi.org/10.1002/jcp.27243DOI Listing
April 2019
1 Read
3.840 Impact Factor

High intensity focused ultrasound cyclocoagulation in dogs with primary glaucoma: a preliminary study.

Open Vet J 2018 13;8(3):305-312. Epub 2018 Aug 13.

Centre Hospitalier Vétérinaire, 275 Route Impériale, 74370 Saint-Martin Bellevue, France.

The objective was to assess the effect of high intensity focused ultrasound (HIFU) on intraocular pressure (IOP) in dogs with primary glaucoma (PG). Seven dogs (13 eyes) presenting with PG as diagnosed by a raised IOP (> 20 mm Hg) associated with consistent gonioscopy and ultrasound biomicroscopy of the ciliary cleft, with no other ocular disease. Patients were divided into 3 groups, corresponding to their pre-operative IOP (group 1 ranging from 21 to 30 mm Hg, group 2 from 31 to 40 and group 3 for 40 and above). Read More

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https://www.ajol.info/index.php/ovj/article/view/176405
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http://dx.doi.org/10.4314/ovj.v8i3.9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102420PMC
August 2018
12 Reads

Processed amniotic membrane for conjunctival reconstruction in complex strabismus surgery.

Strabismus 2018 Aug 21:1-7. Epub 2018 Aug 21.

a Section for Strabismus, Neuroophthalmology and Oculoplastics , Georg-August-Universitat Gottingen Universitatsmedizin , Gottingen , Germany.

Introduction: In ophthalmology amniotic membrane is usually used for the treatment of corneal ulcerations and chemical burns of the ocular surface. Also, it is useful in the treatment of conjunctival defects. There are few publications on the long-term outcomes with the use of amniotic membrane to replace the conjunctiva. Read More

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https://www.tandfonline.com/doi/full/10.1080/09273972.2018.1
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http://dx.doi.org/10.1080/09273972.2018.1502794DOI Listing
August 2018
17 Reads

Where You Cut Matters: A Dissection and Analysis Guide for the Spatial Orientation of the Mouse Retina from Ocular Landmarks.

J Vis Exp 2018 08 4(138). Epub 2018 Aug 4.

Department of Biology, The University of Akron;

Accurately and reliably identifying spatial orientation of the isolated mouse retina is important for many studies in visual neuroscience, including the analysis of density and size gradients of retinal cell types, the direction tuning of direction-selective ganglion cells, and the examination of topographic degeneration patterns in some retinal diseases. However, there are many different ocular dissection methods reported in the literature that are used to identify and label retinal orientation in the mouse retina. While the method of orientation used in such studies is often overlooked, not reporting how retinal orientation is determined can cause discrepancies in the literature and confusion when attempting to compare data between studies. Read More

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http://dx.doi.org/10.3791/57861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126625PMC
August 2018
10 Reads

Corneal epithelial stem cells for corneal injury.

Expert Opin Biol Ther 2018 09 9;18(9):997-1003. Epub 2018 Aug 9.

c Reproductive Medicine, Developmental Biology & Reproduction , University Hospital & School of Medicine, Picardie University Jules Verne , Amiens , France.

Introduction: Ocular surface diseases with limbal insufficiency represent a therapeutic challenge for restoring vision. This corneal deficiency includes both classical ocular diseases (as chemical burns) and rare ocular diseases (as congenital aniridia and ocular cicatricial pemphigoid). Areas covered: Our understanding of limbal epithelial stem cells (LESCs) has increased the potential for treatment options. Read More

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https://www.tandfonline.com/doi/full/10.1080/14712598.2018.1
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http://dx.doi.org/10.1080/14712598.2018.1508443DOI Listing
September 2018
10 Reads

Outcomes of choroidal melanomas treated with eye physics plaques: A 25-year review.

Brachytherapy 2018 Nov - Dec;17(6):981-989. Epub 2018 Aug 3.

USC Roski Eye Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA; The Vision Center at Children's Hospital Los Angeles, Los Angeles, CA. Electronic address:

Purpose: To review long-term outcomes of the University of Southern California Plaque Simulator (PS) software and Eye Physics (EP) plaques. We hypothesize that the PS/EP system delivers lower doses to critical ocular structures, resulting in lower rates of radiation toxicity and favorable visual outcomes compared to Collaborative Ocular Melanoma Study plaques, while maintaining adequate local tumor control.

Methods And Materials: Retrospective review of 133 patients treated for choroidal melanoma with I brachytherapy, using PS software and EP plaques, from 1990 through 2015. Read More

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http://dx.doi.org/10.1016/j.brachy.2018.07.002DOI Listing
August 2018
11 Reads

Amniotic Membrane Adjuncts and Clinical Applications in Wound Healing: A Review of the Literature.

Wounds 2018 Jun;30(6):168-173

Rutgers New Jersey Medical School, Newark, NJ.

Introduction: Recent advances in the preservation and processing of amnion/chorion tissue have dramatically increased the bioavailability of these wound healing factors as well as the shelf life of their related tissue products, allowing for a surge in clinical use. Many studies, including basic science, clinical trials, and randomized controlled trials, have emerged examining the biologic properties of amnion/chorion membrane products and their efficacy in wound healing.

Objective: A literature review was conducted regarding the safety and efficacy of amniotic membrane adjuncts. Read More

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June 2018
10 Reads

Olopatadine enhances recovery of alkali-induced corneal injury in rats.

Life Sci 2018 Aug 3;207:499-507. Epub 2018 Jul 3.

Pharmacology Department, Faculty of Medicine, Tanta University, El-Gish Street, Postal No. 31527 Tanta, Egypt.

Aims: The alkali-induced corneal injury is an ocular emergency that required an immediate and effective management to preserve the normal corneal functions and transparency. Olopatadine is a fast, topically-effective anti-allergic drug, which exhibited potent anti-inflammatory and anti-angiogenic abilities in different allergic animals' models. Therefore, this study aimed to evaluate the therapeutic effect of olopatadine on alkali-induced corneal injury in rats. Read More

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http://dx.doi.org/10.1016/j.lfs.2018.07.002DOI Listing
August 2018
2 Reads

Emerging Therapeutic Strategies for Limbal Stem Cell Deficiency.

J Ophthalmol 2018 27;2018:7894647. Epub 2018 Jun 27.

Department of Dermatology, Northwestern University, Chicago, IL 60611, USA.

Identification and characterization of the limbal epithelial stem cells (LESCs) has proven to be a major accomplishment in anterior ocular surface biology. These cells have been shown to be a subpopulation of limbal epithelial basal cells, which serve as the progenitor population of the corneal epithelium. LESCs have been demonstrated to play an important role in maintaining corneal epithelium homeostasis. Read More

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https://www.hindawi.com/journals/joph/2018/7894647/
Publisher Site
http://dx.doi.org/10.1155/2018/7894647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040301PMC
June 2018
10 Reads

Isolation of acid from eye drop bottles being used by patients presenting with presumed scleritis.

Indian J Ophthalmol 2018 08;66(8):1084-1087

R.S. Mehta Jain Department of Biochemistry and Cell Biology, KBIRVO Block, Vision Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India.

Purpose: The aim of the study was to report the occurrence of contamination/replacement of ophthalmic eye drops with liquids of acidic nature in patients treated for nonresponding scleritis.

Methods: This was a retrospective interventional case series study.

Results: Of the three patients (4 eyes) referred as necrotizing scleritis, two were found to have acid as the content in the bottle/s being used as eye drops, confirmed using biochemical tests. Read More

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http://www.ijo.in/text.asp?2018/66/8/1084/237353
Publisher Site
http://dx.doi.org/10.4103/ijo.IJO_82_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080446PMC
August 2018
3 Reads

Care in patients with epidermal necrolysis in burn units. A nursing perspective.

Burns 2018 Dec 11;44(8):1962-1972. Epub 2018 Jul 11.

Clinical Pharmacology Unit, Príncipe de Asturias University Hospital, Department of Biomedical Sciences, University of Alcalá, IRYCIS, Alcalá de Henares, Madrid, Spain.

Objective: To describe how nursing care is delivered to patients with epidermal necrolysis in burn units/specialized units in Spain and a selection of countries.

Method: Descriptive cross-sectional study. Data were collected through a structured questionnaire which was sent to nurse managers in all burn units in Spain and a selection of countries. Read More

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http://dx.doi.org/10.1016/j.burns.2018.06.010DOI Listing
December 2018
9 Reads

Photokeratitis among restaurant workers: A case series.

Am J Ind Med 2018 Jul 11. Epub 2018 Jul 11.

North Carolina Division of Public Health, Charlotte, North Carolina.

This case report highlights the challenges associated with the diagnosis and workplace evaluation of occupationally acquired ultraviolet (UV) radiation-induced photokeratitis and associated skin burns in a group of restaurant workers. UV-C spectrum bulbs were inadvertently shipped and installed in insect light traps. Ocular and dermal symptoms were reported in 18 of 85 restaurant employees to varying degrees of severity over a 2-day period. Read More

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http://dx.doi.org/10.1002/ajim.22875DOI Listing
July 2018
1 Read

Neurotrophic keratitis: current challenges and future prospects.

Eye Brain 2018 28;10:37-45. Epub 2018 Jun 28.

Ophthalmology Unit, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum University of Bologna, Sant'Orsola-Malpighi Teaching Hospital, Bologna, Italy,

Neurotrophic keratitis (NK) is a degenerative corneal disease caused by damage of trigeminal corneal innervation, which leads to spontaneous epithelial breakdown and corneal ulceration. The impairment of corneal sensory innervation causes the reduction of both protective reflexes and trophic neuromodulators that are essential for the vitality, metabolism, and wound healing of ocular surface tissues. A wide range of ocular and systemic conditions, including herpetic keratitis, ocular chemical burns, corneal surgery, diabetes, multiple sclerosis, and neurosurgical procedures, can cause NK by damaging trigeminal innervation. Read More

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http://dx.doi.org/10.2147/EB.S117261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029608PMC
June 2018
1 Read

Utilisation d’une solution polyamphotère lors de lésions et brûlures chimiques oculaires cutanées et buccales. effet sur la douleur de la diphotérine®.

Ann Burns Fire Disasters 2017 Dec;30(4):286-291

Colorado School of Public Health, Denver, Colorado, USA.

Polyamphoteric washing solutions (PWS) have been used for several years, mainly in industries, for cases of chemical ocular or cutaneous splashes by acid or alkali. We collected 37 cases reporting the use of PWS for ocular and cutaneous chemical splashes from several centres. Among the 37 cases, 55. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033482PMC
December 2017
2 Reads

Early Results of Penetrating Keratoplasty in Patients With Unilateral Chemical Injury After Simple Limbal Epithelial Transplantation.

Cornea 2018 Oct;37(10):1249-1254

Department of Cornea, Refractive Surgery and Ocular Surface Disorders, Dr. Shroff's Charity Eye Hospital, Daryaganj, New Delhi, India.

Purpose: To evaluate clinical outcomes of sequential PKP in eyes with unilateral chemical injury, which have previously undergone autologous simple limbal epithelial transplantation (SLET) at a tertiary eye center in North India.

Methods: This is a single-center, retrospective, noncomparative interventional case series reviewing patients with unilateral limbal stem cell deficiency treated by SLET and sequential PKP between 2012 and 2017. The primary outcome was defined as allograft survival, defined as a completely epithelialized, clear, avascular graft. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001681DOI Listing
October 2018
13 Reads

Amniotic membrane extract and eye drops: a review of literature and clinical application.

Clin Ophthalmol 2018 18;12:1105-1112. Epub 2018 Jun 18.

HDR Research Center, Hoopes Vision, Draper, UT, USA.

The amniotic membrane (AM) has a long history of use in the treatment of various diseases of the ocular surface. It contains pluripotent cells, highly organized collagen, anti-fibrotic and anti-inflammatory cytokines, immune-modulators, growth factors, and matrix proteins. It is used to promote corneal healing in severely damaged eyes. Read More

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http://dx.doi.org/10.2147/OPTH.S165553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6012548PMC
June 2018
20 Reads

Use of an ocular wound chamber for the prevention of exposure keratopathy in a guinea pig model.

Wound Repair Regen 2018 Sep 24;26(5):351-358. Epub 2018 Oct 24.

Department of Sensory Trauma, United States Army Institute of Surgical Research, San Antonio, Texas.

Current therapies available to treat and heal ocular surface injuries and periocular burns are frequently inadequate, costly, and labor intensive. To address these limitations, we have employed a flexible, semitransparent ocular wound chamber (OWC) to provide protection as well as a watertight seal to allow for the constant delivery of therapeutics to the ocular surface and surrounding periocular tissue. This study demonstrates the safety and utilization of the OWC on uninjured eyes and in our exposure keratopathy model. Read More

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http://dx.doi.org/10.1111/wrr.12644DOI Listing
September 2018
9 Reads

Therapeutic effects of proanthocyanidin and coenzyme Q10 on nitrogen mustard-induced ocular injury.

Arq Bras Oftalmol 2018 Jun;81(3):226-231

Department of Cornea and Refractive Surgery, Gulhane Military Medical Academy, Ankara, Turkey.

Purpose: Nitrogen mustard (NM) is a devastating casualty agent in chemical warfare. There is no effective antidote to treat NM-induced ocular injury. We aimed to assess the effects of proanthocyanidin (PAC) and coenzyme Q10 (CoQ10) on NM-induced ocular injury. Read More

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http://dx.doi.org/10.5935/0004-2749.20180045DOI Listing
June 2018
14 Reads

Long-term outcomes with Boston type 1 keratoprosthesis in ocular burns.

Arq Bras Oftalmol 2018 Jun;81(3):177-182

Department of Ophthalmology, Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Purpose: To evaluate the long-term outcomes of Boston type I keratoprosthesis (B-Kpro) in the management of patients with ocular burn injuries.

Methods: This prospective study included all patients with ocular burns who underwent B-Kpro implantation at a tertiary eye care center between February 2008 and November 2015. Twelve patients (12 eyes) were enrolled. Read More

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http://dx.doi.org/10.5935/0004-2749.20180038DOI Listing
June 2018
4 Reads

Therapeutic Effects of Topical 8-Oxo-2'-deoxyguanosine on Ethanol-Induced Ocular Chemical Injury Models.

Cornea 2018 Oct;37(10):1311-1317

Gachon University College of Medicine, Incheon, Korea.

Purpose: To evaluate the therapeutic effects of topical 8-oxo-2'-deoxyguanosine (8-oxo-dG) on experimental ocular chemical injury models.

Methods: We created ocular chemical injury models with 8-week-old BALB/c mice (n = 70) by applying 100% ethanol; the mice were then treated with 8-oxo-dG eye drops 10 and 5 mg/mL and phosphate-buffered saline (PBS) twice daily. After 7 days, clinical findings such as corneal integrity, clarity, and neovascularization were assessed. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001671DOI Listing
October 2018
12 Reads

[Chemical burns caused by crust anemone].

Ophthalmologe 2018 Jun 19. Epub 2018 Jun 19.

Augenklinik und Poliklinik, Universitätsmedizin Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland.

We present a case of a toxic reaction in both eyes caused by secretions from an encrusting anemone of the genus Protopalythoa. The patient presented with chemosis and follicular reaction of the conjunctiva and whitish spots on the limbus. Under local treatment with steroids and antibiotic eyedrops, remission was achieved within a few days. Read More

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http://dx.doi.org/10.1007/s00347-018-0742-9DOI Listing
June 2018
1 Read

[How to improve the prevention and treatment of ocular chemical burns in China: important elements].

Authors:
Y F Huang L L Wang

Zhonghua Yan Ke Za Zhi 2018 Jun;54(6):401-405

The General Hospital of Chinese PLA, Medical School of Chinese PLA, Beijing 100853, China.

Ocular chemical burns are common and serious ocular emergencies which require immediate and intensive evaluation and treatment. Loss of vision and disfigurement affect the victims, bringing great sufferings to themselves and their families. China is the biggest developing country in the world with a large number of such cases. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2018.06.001DOI Listing
June 2018
14 Reads

The Ex vivo Eye Irritation Test (EVEIT) model as a mean of improving venom ophthalmia understanding.

Toxicon 2018 Aug 8;150:253-260. Epub 2018 Jun 8.

Immunochemistry Laboratory, Butantan Institute, São Paulo, Brazil. Electronic address:

Snakes belonging to the genus Naja (Elapid family), also known as "spitting cobras", can spit venom towards the eyes of the predator as a defensive strategy, causing painful and potentially blinding ocular envenoming. Venom ophthalmia is characterized by pain, hyperemia, blepharitis, blepharospasm and corneal erosions. Elapid venom ophthalmia is not well documented and no specific treatment exists. Read More

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http://dx.doi.org/10.1016/j.toxicon.2018.06.061DOI Listing
August 2018
1 Read

Periocular CO laser resurfacing: severe ocular complications from multiple unintentional laser impacts on the protective metal eye shields.

Lasers Surg Med 2018 Dec 8;50(10):980-986. Epub 2018 Jun 8.

Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands.

Background And Objectives: A 36-year-old woman underwent CO laser resurfacing for periocular rhytides using protective stainless steel Cox II ocular shields. Immediately after the treatment, corneal lesions were seen in both eyes. The left eye subsequent developed corneal ulceration and scarring, a deformed iris, cataract, and lower eye lashes showing signs of acute burns. Read More

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http://dx.doi.org/10.1002/lsm.22951DOI Listing
December 2018
3 Reads

Total Penetrating Keratoplasty: Indications, Therapeutic Approach, and Long-Term Follow-Up.

J Ophthalmol 2018 19;2018:9580292. Epub 2018 Apr 19.

Department of Ophthalmology with Pediatric Unit, St. Barbara Hospital, Trauma Center, Medykow Square 1, 41-200 Sosnowiec, Poland.

Purpose: Evaluation of the indications, anatomical and functional results, and complications of total penetrating keratoplasty (TPK) in disorders involving whole cornea.

Materials And Methods: We analyzed outcomes of the surgical treatment of 47 eyes of 46 patients that underwent TPK. Indications were infectious keratitis, autoimmune disease, injury of the eyeball (mainly chemical burns), and other combined disorders. Read More

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http://dx.doi.org/10.1155/2018/9580292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5933013PMC
April 2018
11 Reads

Simple limbal epithelial transplantation: a review on current approach and future directions.

Surv Ophthalmol 2018 Nov - Dec;63(6):869-874. Epub 2018 May 22.

International Center for Ocular Physiopathology, The Veneto Eye Bank Foundation, Venice, Italy. Electronic address:

Simple limbal epithelial transplantation is a recently developed technique for treating limbal stem cell deficiency caused by ocular burns. A small limbal biopsy from the donor eye, usually from the patient's healthy eye, is excised and dissected into multiple pieces. An amniotic membrane is atttached using fibrin glue on the diseased eye after removing the conjunctivalized pannus from the corneal surface. Read More

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http://dx.doi.org/10.1016/j.survophthal.2018.05.003DOI Listing
November 2018
4 Reads