1,656 results match your criteria Burns Ocular

ABCC6, Pyrophosphate and Ectopic Calcification: Therapeutic Solutions.

Int J Mol Sci 2021 Apr 27;22(9). Epub 2021 Apr 27.

Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96817, USA.

Pathological (ectopic) mineralization of soft tissues occurs during aging, in several common conditions such as diabetes, hypercholesterolemia, and renal failure and in certain genetic disorders. Pseudoxanthoma elasticum (PXE), a multi-organ disease affecting dermal, ocular, and cardiovascular tissues, is a model for ectopic mineralization disorders. ABCC6 dysfunction is the primary cause of PXE, but also some cases of generalized arterial calcification of infancy (GACI). Read More

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Upregulated Expression of Activation-Induced Cytidine Deaminase in Ocular Adnexal Marginal Zone Lymphoma with IgG4-Positive Cells.

Int J Mol Sci 2021 Apr 15;22(8). Epub 2021 Apr 15.

Division of Pathophysiology, Okayama University Graduate School of Health Sciences, Okayama 700-8558, Japan.

Immunoglobulin G4-related disease (IgG4-RD) is a systemic disorder characterized by tissue fibrosis and intense lymphoplasmacytic infiltration, causing progressive organ dysfunction. Activation-induced cytidine deaminase (AID), a deaminase normally expressed in activated B-cells in germinal centers, edits ribonucleotides to induce somatic hypermutation and class switching of immunoglobulin. While AID expression is strictly controlled under physiological conditions, chronic inflammation has been noted to induce its upregulation to propel oncogenesis. Read More

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Surgical Management and Recent Advances in Chemical Injury: A 5-year Review.

Semin Ophthalmol 2021 Apr 25:1-7. Epub 2021 Apr 25.

Department of Ophthalmology, All India Institute of Medical Sciences, Patna, India.

: To review the surgical management options in ocular chemical burn, including newer advances.: Online literature search of published articles over last 5 years on surgical management of ocular chemical burn and newer advances were performed on December 30, 2020.: Following literature search and screening using adequate filters, 67 review articles on surgical management of ocular chemical burns were retrieved. Read More

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Synthetic high-density lipoprotein nanoparticles: Good things in small packages.

Ocul Surf 2021 Apr 21;21:19-26. Epub 2021 Apr 21.

Department of Dermatology Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address:

Medicine has been a great beneficiary of the nanotechnology revolution. Nanotechnology involves the synthesis of functional materials with at least one size dimension between 1 and 100 nm. Advances in the field have enabled the synthesis of bio-nanoparticles that can interface with physiological systems to modulate fundamental cellular processes. Read More

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Epigenetic Landscape Analysis of the Long Non-Coding RNA and Messenger RNA in a Mouse Model of Corneal Alkali Burns.

Invest Ophthalmol Vis Sci 2021 Apr;62(4):28

Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, People's Republic of China.

Purpose: Corneal alkali burns (CABs) are a common clinical ocular disease, presenting a poor prognosis. Although some long noncoding RNAs (lncRNAs) reportedly play a key role in epigenetic regulation associated with CABs, studies regarding the lncRNA signature in CABs remain rare and elusive.

Methods: A CAB model was established in C57BL/6J mice and profiling of lncRNA expressions was performed by RNA-Seq. Read More

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[Expert consensus on the clinical diagnosis and treatment of eye burns in China (2021)].


Zhonghua Yan Ke Za Zhi 2021 Apr;57(4):254-260

Eye burns, which are usually caused by chemicals such as acidic, alkaline and heat-related substances, are true medical emergencies. These substances can lead to potential permanent damage to the eyelids, cornea, ocular surface and intraocular tissues. In severe cases, eye burns may result in blindness. Read More

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Chemical and thermal ocular burns in the United States: An IRIS registry analysis.

Ocul Surf 2021 Mar 31. Epub 2021 Mar 31.

Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA. Electronic address:

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Effect of mesenchymal stromal cells encapsulated within polyethylene glycol-collagen hydrogels formed in situ on alkali-burned corneas in an ex vivo organ culture model.

Cytotherapy 2021 Mar 19. Epub 2021 Mar 19.

Department of Ophthalmology, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, California, USA; Department of Chemical and Biological Engineering, Gachon University, Seongnam-si, South Korea; VA Palo Alto HealthCare System, Palo Alto, California, USA. Electronic address:

Background Aims: Corneal inflammation after alkali burns often results in vision loss due to corneal opacification and neovascularization. Mesenchymal stem cells (MSCs) and their secreted factors (secretome) have been studied for their anti-inflammatory and anti-angiogenic properties with encouraging results. However, topical instillation of MSCs or their secretome is often accompanied by issues related to delivery or rapid washout. Read More

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PLGA nanoparticles containing Lingzhi extracts rescue corneal epithelial cells from oxidative damage.

Exp Eye Res 2021 May 17;206:108539. Epub 2021 Mar 17.

Department of Materials Science and Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan. Electronic address:

Oxidative stress-related ocular surface epithelial damage can be initiated by ambient oxygen, UV radiation, and chemical burns. The oxidative damage to cornea can lead to inflammation and even vision loss. Lingzhi (Ganoderma lucidum) is a Chinese herbal drug and has been shown to prevent chronic diseases in clinical practices and has been proven to possess anti-oxidative and anti-inflammatory properties. Read More

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Recurrent contracted sockets treated with personalized, three-dimensionally printed conformers and buccal grafts.

Eur J Ophthalmol 2021 Mar 11:11206721211000013. Epub 2021 Mar 11.

Amsterdam UMC, Department of Ophthalmology, Amsterdam Orbital Center, University of Amsterdam, Meibergdreef 9, Amsterdam, the Netherlands.

Purpose: Recurrent contracted sockets are complex situations where previous surgeries have failed, disabling the wear of an ocular prosthesis. A combined method of surgery and long-term fixation using custom-made, three-dimensional (3D) printed conformers is evaluated.

Methods: Retrospective case series of nine patients with recurrent excessive socket contraction and inability to wear a prosthesis, caused by chemical burns ( = 3), fireworks ( = 3), trauma ( = 2) and enucleation and radiotherapy at childhood due to optic nerve glioma ( = 1) with three average previous socket surgeries (range 2-6). Read More

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[Simple limbal epithelial transplantation (SLET) : A simple technique for the treatment of unilateral complete limbal stem cell deficiency. Video article].

Ophthalmologe 2021 Apr 8;118(4):404-412. Epub 2021 Mar 8.

Klinik für Augenheilkunde, Uniklinik RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.

Objective: The aim of simple limbal epithelial transplantation (SLET) is the regeneration of the corneal surface in unilateral complete limbal stem cell deficiency (LSCD).

Indications: SLET is indicated for unilateral complete LSCD.

Contraindications: Contraindications include bilateral LSCD, severe corneal thinning, pronounced keratoconjunctivitis sicca, chronic inflammatory condition of the ocular surface, malposition of the eyelids and pronounced adhesions of the conjunctiva with trichiasis. Read More

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Long-term outcomes of Boston keratoprosthesis type I: the Chinese People's Liberation Army General Hospital experience.

Br J Ophthalmol 2021 Mar 5. Epub 2021 Mar 5.

Department of Ophthalmology, General Hospital of People's Liberation Army, Beijing, China

Purpose: To report the long-term outcomes of Boston keratoprosthesis type I (B-KPro type I) implantation in the management of severe ocular surface disorders.

Methods: Retrospective case series. Patients who underwent B-KPro type I implantation at the People's Liberation Army General Hospital were enrolled between March 2011 and September 2019. Read More

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Long term observation of ocular surface alkali burn in rabbit models: Quantitative analysis of corneal haze, vascularity and self-recovery.

Exp Eye Res 2021 Apr 2;205:108526. Epub 2021 Mar 2.

Stem Cell Laboratory, Prof. Brien Holden Eye Research Center, L V Prasad Eye Institute, Hyderabad, Telangana, India; Center for Ocular Regeneration (CORE), LV Prasad Eye Institute, Hyderabad, Telangana, India. Electronic address:

Limbal Stem Cell Deficiency (LSCD), caused due to corneal injury, primarily by chemical/alkali burns, leads to compromised vision. Recently, several animal models of corneal alkali burn injury have become available. The majority of the studies with these animal models start interventions soon after the injury. Read More

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Letter to the Editor Regarding "Global Burn Registry Perspective on Head and Neck Burns".

Ann Plast Surg 2021 Mar 3. Epub 2021 Mar 3.

Ophthalmologist Retina and Vitreo Trauma, Servicio de Oftalmologia Grupo de Investigación en Visión y Salud Ocular, VISOC, Universidad del Valle Cali, Colombia

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).

Autophagy 2021 Jan 8;17(1):1-382. Epub 2021 Feb 8.

University of Crete, School of Medicine, Laboratory of Clinical Microbiology and Microbial Pathogenesis, Voutes, Heraklion, Crete, Greece; Foundation for Research and Technology, Institute of Molecular Biology and Biotechnology (IMBB), Heraklion, Crete, Greece.

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Read More

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January 2021

Regenerative Therapy Using Umbilical Cord Serum.

In Vivo 2021 Mar-Apr;35(2):699-705

Department of Otolaryngology, Chonnam National University Medical School, Gwangju, Republic of Korea

Regenerative medicine is a branch of medicine that incorporates tissue-engineering, biomaterials, and cell therapy approaches to replace or repair damaged cells and tissues. Umbilical cord serum (UCS) is an important liquid component of cord blood, which has a reliable source of innumerable growth factors and biologically active molecules. Usually, serum can be prepared from different sources of blood. Read More

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December 2020

Management of White-Eyed Blowout Fracture in the Pediatric Population.

J Maxillofac Oral Surg 2021 Mar 22;20(1):37-41. Epub 2020 Jun 22.

Department of Plastic Surgery, Hand Surgery, Reconstructive Microsurgery, Facio Maxillary Surgery, Aesthetic Surgery, Oncoplastic Breast Surgery and Burns, Ganga Hospital, Coimbatore, India.

Aims And Objectives: Diplopia in children is uncommon. However a small group of patients present with diplopia and severe restriction of upward globe movement which requires early diagnosis and prompt intervention. This study aims to evaluate the timing of intervention and functional outcome in the management of white-eyed blowout fractures. Read More

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Use of Acellular Umbilical Cord-Derived Tissues in Corneal and Ocular Surface Diseases.

Medicines (Basel) 2021 Feb 9;8(2). Epub 2021 Feb 9.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

Blood derived products have become a valuable source of tissue for the treatment of ocular surface diseases that are refractory to conventional treatments. These can be obtained from autologous or allogeneic sources (patient's own blood or from healthy adult donors/umbilical cord blood, respectively). Allogeneic cord blood demonstrates practical advantages over alternatives and these advantages will be discussed herein. Read More

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February 2021

Allogeneic simple limbal epithelial transplantation: an appropriate treatment for bilateral stem cell deficiency.

BMJ Case Rep 2021 Feb 5;14(2). Epub 2021 Feb 5.

Cornea and Anterior Segment, LV Prasad Eye Institute, Bhubaneswar, Odisha, India

A 39-year-old man presented with both eyes limbal stem cell deficiency status post chemical injury. He was managed initially with topical medications to subside the ocular surface inflammation. Over the course of subsequent visits, the fibrovascular pannus over the cornea gradually progressed, leading to further diminution of vision in left eye more than right eye. Read More

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February 2021

Regenerative Approaches and Future Trends for the Treatment of Corneal Burn Injuries.

J Clin Med 2021 Jan 16;10(2). Epub 2021 Jan 16.

Institute of Biostructure and Bioimaging, National Research Council, Molecular Biotechnology Center, 10126 Turin, Italy.

Ocular chemical and thermal burns are frequent causes of hospitalization and require immediate interventions and care. Various surgical and pharmacological treatment strategies are employed according to damage severity. Controlling inflammation and neovascularization while promoting normal ocular surface anatomy and function restoration is the principal aim. Read More

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January 2021

Subconjunctival injection of mesenchymal stem cells for corneal failure due to limbal stem cell deficiency: state of the art.

Stem Cell Res Ther 2021 Jan 13;12(1):60. Epub 2021 Jan 13.

Instituto de Oftalmobiología Aplicada (IOBA), Universidad de Valladolid, Edificio IOBA, Campus Miguel Delibes, Paseo de Belén 17, 47011, Valladolid, Spain.

Mesenchymal stem cells (MSCs) have unique and beneficial properties and are currently used to treat a broad variety of diseases. These properties include the potential for differentiation into other cell types, secretion of different trophic factors that promote a regenerative microenvironment, anti-inflammatory actions, selective migration to damaged tissues, and non-immunogenicity. MSCs are effective for the treatment of ocular surface diseases such as dry eye, corneal burns, and limbal stem cell deficiency (LSCD), both in experimental models and in humans. Read More

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January 2021

Endophthalmitis in Eyes With the Boston Type I Keratoprosthesis: Incidence, Recurrence, Risk Factors, and Outcomes.

Cornea 2020 Dec 31;Publish Ahead of Print. Epub 2020 Dec 31.

Department of Ophthalmology, Centre hospitalier de l'Université de Montréal, Montreal, Canada; and Department of Ophthalmology, King Abdulaziz University, Jeddah, Saudi Arabia.

Purpose: To determine the incidence and recurrence of Boston type I keratoprosthesis (KPro)-associated endophthalmitis, and its microbiological profile, risk factors, and outcomes.

Methods: This is a retrospective study of 158 consecutive KPro procedures with a median follow-up of 78.4 months. Read More

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December 2020

Characterization of Medical Malpractice Litigation after Rhinoplasty in the United States.

Aesthet Surg J 2020 Dec 17. Epub 2020 Dec 17.

Department of Otolaryngology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, United States.

Background: Rhinoplasty is one of the most common operations performed with favorable results and high patient satisfaction. However, when complications occur or when the desired outcome is not achieved, patients may seek litigation on the premise that there was a violation in the standard of care. Knowledge of malpractice claims can inform rhinoplasty surgeons on how to minimize risk of future litigation as well as improve patient satisfaction. Read More

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December 2020

Heparin-Modified Amniotic Membrane Combined With Growth Factors for Promoting Corneal Wound Healing After Alkali Burn.

Front Bioeng Biotechnol 2020 23;8:599800. Epub 2020 Nov 23.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Ocular chemical burns are potentially blinding ocular injuries and require urgent management. Amniotic membrane (AM) transplantation is an effective surgical treatment, one of the reasons is because AM is a rich source of growth factors that can promote epithelialization and wound healing. However, growth factors will be gradually lost and insufficient after preparation process and long-time storage, leading to unsatisfactory therapeutic effects. Read More

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November 2020

Immunocytochemistry of the ocular surface after different techniques of limbal stem cell transplantation for chronic chemical burns.

Br J Ophthalmol 2020 Dec 16. Epub 2020 Dec 16.

Ophthalmology, Guru Nanak Eye Centre, New Delhi, Delhi, India.

Aim: To compare the immunocytochemistry (ICC) on impression cytology of corneal surface epithelium after simple limbal epithelial transplantation (SLET) and conjunctival-limbal autograft (CLAU).

Methods: A prospective study of 20 patients above 1 year of age with chronic chemical burns, who underwent limbal stem cell transplantation (LSCT). They were divided equally in group A (SLET) and group B (CLAU). Read More

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December 2020

Commentary: The role of amniotic membrane transplantation in the management of acute ocular chemical burns.

Indian J Ophthalmol 2021 01;69(1):64-65

The Cornea Institute; Brien Holden Eye Research Centre (BHERC), L V Prasad Eye Institute, Hyderabad, Telangana, India.

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January 2021

Amniotic membrane transplant in acute ocular surface burns in Western India: A tertiary eye care center study.

Indian J Ophthalmol 2021 01;69(1):58-64

Cornea Department, M and J Institute of Ophthalmology (Government Eye Hospital), B.J. Medical College, Ahmedabad, Gujarat, India.

Purpose: To evaluate the outcomes of early amniotic membrane transplant (AMT) in acute ocular surface burns using Dua's classification.

Methods: In this retrospective analysis conducted at a tertiary eye care center in Western India. We included 27 eyes of 24 patients from May 2014 to May 2019 who underwent AMT within 2 weeks post insult along with medical treatment for acute ocular surface burns using Dua's classification for grading on presentation. Read More

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January 2021

Serial anterior segment optical coherence tomography post autologous simple limbal epithelial transplantation.

BMJ Case Rep 2020 Dec 13;13(12). Epub 2020 Dec 13.

The Cornea Institute, LV Prasad Eye Institute, Hyderabad, Telangana, India

A 24-year-old young man presented to us with total limbal stem cell deficiency (LSCD) in the right eye 1 year post ocular chemical burn. The patient subsequently underwent limbal biopsy in the healthy contralateral eye and autologous simple limbal epithelial transplantation in the right eye. The patient was followed up with sequential imaging of the cornea with high-resolution anterior segment optical coherence tomography (HR-ASOCT) for 3 years. Read More

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December 2020

First Evaluation of a Retinal Imaging Laser Eyewear System Based Low Vision Aid.

Clin Ophthalmol 2020 30;14:4115-4123. Epub 2020 Nov 30.

Department of Ophthalmology, University Hospital Essen, Essen, Germany.

Purpose: We conducted this trial to investigate a new wearable laser-eyewear (LEW). Images of an integrated camera are projected to the retina by a RGB-Laser (<1µW) and MEMS-mirror system. This enables a full-color live video as augmented reality embedded in the field of vision of the wearer. Read More

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November 2020

Simultaneous surgical management of unilateral limbal stem cell deficiency and symblepharon post chemical burn.

BMJ Case Rep 2020 Dec 9;13(12). Epub 2020 Dec 9.

The Cornea Institute, LV Prasad Eye Institute, Hyderabad, Telangana, India

A 6-year-old female child presented with severe acute ocular chemical burn in the right eye 2 days after injury with cement. She underwent removal of all foreign bodies from the ocular surface and amniotic membrane transplantation. Three months later, she developed unilateral total limbal stem cell deficiency (LSCD) with symblepharon in two quadrants. Read More

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December 2020