1,576 results match your criteria Burns Ocular


Agents Involved and Severity of Acute Ocular Exposure Reported at a Poison Control Center.

Ophthalmic Epidemiol 2020 Jun 5:1-9. Epub 2020 Jun 5.

Grand Ouest Poison Control and Toxicovigilance Center, University Hospital , Angers, France.

Purpose: The aim was to identify severity factors useful in the initial management of patients with acute ocular exposure while considering both categories of products involved and circumstances of exposure.

Methods: A retrospective study over a one-year period that included patients who benefited from the poison center services for eye exposure to a chemical substance.

Results: Within a year, 1582 patients were identified. Read More

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http://dx.doi.org/10.1080/09286586.2020.1773871DOI Listing

Treatment of Oculoplastic and Ocular Surface Disease in Eyes Implanted with a Type I Boston Keratoprosthesis in Southern China: A Retrospective Study.

Adv Ther 2020 May 20. Epub 2020 May 20.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, 510060, China.

Introduction: This study aimed to describe the clinical features, surgical management of the eyelid and ocular surface, and outcomes of 16 patients implanted with a Boston type I keratoprosthesis (KPro).

Methods: A retrospective, single-center, consecutive case series of 16 patients with Stevens-Johnson syndrome (1), ocular chemical burns (12), and ocular thermal burns (3) implanted with KPro was studied. All subjects were men aged 27-51 years. Read More

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http://dx.doi.org/10.1007/s12325-020-01381-3DOI Listing

Spectrum of Ocular Injuries and Visual Outcome Following Firework Injury to the Eye.

J Emerg Trauma Shock 2020 Jan-Mar;13(1):39-44. Epub 2020 Mar 19.

Department of Ophthalmology, Christian Medical College, Vellore, Tamil Nadu, India.

Background: Ocular injury due to fireworks requires urgent ophthalmic assessment and management to preserve vision.

Methods: Spectrum of injury, type of intervention, visual outcome, and reasons for visual loss were assessed in consecutive patients presenting over 2 years with firework-related eye injury. The final visual outcome was recorded as best-corrected visual acuity. Read More

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http://dx.doi.org/10.4103/JETS.JETS_62_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204946PMC

Longitudinal Development of Ocular Misalignment in Nonhuman Primate Models for Strabismus.

Invest Ophthalmol Vis Sci 2020 Apr;61(4)

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Purpose: To investigate the longitudinal change in horizontal and vertical ocular alignment in normal and prism-reared infant monkeys during the critical developmental period.

Methods: Ocular alignment was measured using Hirschberg photographic methods in 6 infant monkeys reared under prism-viewing from day 1 after birth to 4 months, and 2 monkeys reared with normal visual experience. Photographs were acquired twice a week for the first 6 months of life and analyzed to identify pupil center and the first Purkinje image from which eye positions and strabismus angle were calculated. Read More

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http://dx.doi.org/10.1167/iovs.61.4.8DOI Listing

Ocular Thermal Burn Injury in the Emergency Department.

Cureus 2020 Feb 28;12(2):e7137. Epub 2020 Feb 28.

Emergency Medicine, Envision Physician Services, Orlando, USA.

We present a case of an ocular thermal burn from a cooking accident where vegetable oil splashed into the patient's face. The emergency department evaluation and management of ocular thermal burns is discussed. Prompt evaluation, copious irrigation, and consultation with ophthalmology are recommended. Read More

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http://dx.doi.org/10.7759/cureus.7137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105268PMC
February 2020

[Clinical observation of electroretinogram examination in ocular alkali burn].

Authors:
X Xie W Y Wu Y Feng

Zhonghua Yi Xue Za Zhi 2020 Mar;100(10):763-766

Department of Ophthalmology, Peking University Third Hospital, Beijing 100191, China.

To investigate the wave variations of the electroretinography (ERG), and explore the clinical value of using ERG in alkali injury. A total of 13 patients with alkali burns who were treated in the Department of Ophthalmology of Peking University Third Hospital from May 2018 to October 2019 were selected, including 12 males and 1 female. The age ranged from 19 to 60 years old. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20190827-01905DOI Listing

Glaucoma after ocular chemical burns: Incidence, risk factors, and outcome.

Sci Rep 2020 Mar 16;10(1):4763. Epub 2020 Mar 16.

Laboratory of Ocular Regenerative Medicine and Immunology, Seoul National University Hospital Biomedical Research Institute, Seoul, Korea.

Effects of chemical injuries on the cornea and limbus have been widely studied; however, little is known about glaucoma after ocular chemical injuries. We herein investigated the incidence, risk factors, and outcome of glaucoma in patients with ocular chemical burns. Medical records were reviewed of patients who visited our clinic for chemical injuries to the ocular surface. Read More

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http://dx.doi.org/10.1038/s41598-020-61822-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076008PMC

A case of isolated bilateral cataract following high-voltage electrical injury.

Oman J Ophthalmol 2020 Jan-Apr;13(1):34-36. Epub 2020 Feb 17.

Department of Ophthalmology, King George's Medical University, Lucknow, Uttar Pradesh, India.

High voltage electric burns can cause various ocular injuries and may manifest in the form of conjunctival hyperemia, corneal opacities, uveitis, miosis, spasm of accommodation, cataract, retinal edema, papilledema, choroidal rupture, chorio-retinal necrosis/atrophy, retinal detachment and optic atrophy. The involvement of crystalline lens exclusively with sparing of other ocular structures is rare. We report a case of 16 year old male with bilateral total cataract after electrical injury by over-head high tension electric transmission cable accidentally falling on patient's head 6 months back. Read More

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http://dx.doi.org/10.4103/ojo.OJO_129_2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050452PMC
February 2020

Mapping of proteomic profile and effect of the spongy layer in the human amniotic membrane.

Cell Tissue Bank 2020 Jun 12;21(2):329-338. Epub 2020 Mar 12.

Faculty of Medicine and Pharmacy, University of Rouen Normandy, Inserm U1234, Rouen, France.

The graft of human amniotic membrane (HAM) contributes to the healing of corneal perforating ulcers and so to save a large number of eyes suffering of severe chemical burns. This biological material is used for the treatment of ocular surface diseases because of its capacity to reduce inflammation and promote a quicker wound healing. For clinical use, the HAM is denuded from its spongy layer, but this layer can be an important source of growth factors which promote re-epithelialization. Read More

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http://dx.doi.org/10.1007/s10561-020-09821-8DOI Listing

[Osteo-odonto-keratoprosthesis: a tooth to regain sight].

Rev Med Liege 2020 Mar;75(3):164-170

Service de Chirurgie plastique et maxillo-faciale, CHU Liège, Belgique.

As the leading cause of blindness in the world, corneal diseases are second only to cataracts. However, the epidemiology of corneal disease is complex and includes a wide variety of infectious and inflammatory eye diseases (trachoma), immune sequelae (cicatricial pemphigoid on Lyell's disease) of after trauma (chemical burn). The general treatment for severe corneal disease is the corneal transplantation with penetrating keratoplasty. Read More

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Ultra-small nanocomplexes based on polyvinylpyrrolidone K-17PF: A potential nanoplatform for the ocular delivery of kaempferol.

Eur J Pharm Sci 2020 Apr 5;147:105289. Epub 2020 Mar 5.

Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China; Key Laboratory of Pharmaceutical Research for Metabolic Diseases, Qingdao University of Science and Technology, Qingdao 266042, China. Electronic address:

This study aims to create and evaluate a kaempferol (KAE) ophthalmic solution based on polyvinylpyrrolidone (PVP) nanocomplexes. KAE can be highly complexed with PVP K-17PF (17PF) to formulate an aqueous ophthalmic solution named 17PF-KAE. The optimized 17PF-KAE displays high complexing efficiency, an ultra-small size (8. Read More

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http://dx.doi.org/10.1016/j.ejps.2020.105289DOI Listing

Clinical Outcomes From Cultivated Allogenic Stem Cells vs. Oral Mucosa Epithelial Transplants in Total Bilateral Stem Cells Deficiency.

Front Med (Lausanne) 2020 18;7:43. Epub 2020 Feb 18.

Department of Ophthalmology, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Total bilateral limbal stem cell deficiency results from various pathologies, from burns (either chemical or physical) to Sjogren Syndrome, aniridia or ocular cicatricial pemphigoid. After the loss of stem cells, normal corneal epithelium is replaced by a more opaque and vascularized conjunctival epithelium, causing loss of vision. After 1997, cultivation techniques for limbal stem cells became possible. Read More

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http://dx.doi.org/10.3389/fmed.2020.00043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040221PMC
February 2020

Initial Experience with Autologous Skin Cell Suspension for Treatment of Deep Partial-Thickness Facial Burns.

J Burn Care Res 2020 Mar 2. Epub 2020 Mar 2.

Department of General Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina.

Facial burns present a challenge in burn care, as hypertrophic scarring and dyspigmentation can interfere with patients' personal identities, ocular and oral functional outcomes, and have long-term deleterious effects. The purpose of this study is to evaluate our initial experience with non-cultured, autologous skin cell suspension (ASCS) for the treatment of deep partial-thickness (DPT) facial burns. Patients were enrolled at a single burn center during a multicenter, prospective, single-arm, observational study involving the compassionate use of ASCS for the treatment of large total body surface area (TBSA) burns. Read More

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http://dx.doi.org/10.1093/jbcr/iraa037DOI Listing

Global Retinoblastoma Presentation and Analysis by National Income Level.

Authors:
Ido Didi Fabian Elhassan Abdallah Shehu U Abdullahi Rula A Abdulqader Sahadatou Adamou Boubacar Dupe S Ademola-Popoola Adedayo Adio Armin R Afshar Priyanka Aggarwal Ada E Aghaji Alia Ahmad Marliyanti N R Akib Lamis Al Harby Mouroge H Al Ani Aygun Alakbarova Silvia Alarcón Portabella Safaa A F Al-Badri Ana Patricia A Alcasabas Saad A Al-Dahmash Amanda Alejos Ernesto Alemany-Rubio Amadou I Alfa Bio Yvania Alfonso Carreras Christiane Al-Haddad Hamoud H Y Al-Hussaini Amany M Ali Donjeta B Alia Mazin F Al-Jadiry Usama Al-Jumaly Hind M Alkatan Charlotta All-Eriksson Ali A R M Al-Mafrachi Argentino A Almeida Khalifa M Alsawidi Athar A S M Al-Shaheen Entissar H Al-Shammary Primawita O Amiruddin Romanzo Antonino Nicholas J Astbury Hatice T Atalay La-Ongsri Atchaneeyasakul Rose Atsiaya Taweevat Attaseth Than H Aung Silvia Ayala Baglan Baizakova Julia Balaguer Ruhengiz Balayeva Walentyna Balwierz Honorio Barranco Covadonga Bascaran Maja Beck Popovic Raquel Benavides Sarra Benmiloud Nissrine Bennani Guebessi Rokia C Berete Jesse L Berry Anirban Bhaduri Sunil Bhat Shelley J Biddulph Eva M Biewald Nadia Bobrova Marianna Boehme H C Boldt Maria Teresa B C Bonanomi Norbert Bornfeld Gabrielle C Bouda Hédi Bouguila Amaria Boumedane Rachel C Brennan Bénédicte G Brichard Jassada Buaboonnam Patricia Calderón-Sotelo Doris A Calle Jara Jayne E Camuglia Miriam R Cano Michael Capra Nathalie Cassoux Guilherme Castela Luis Castillo Jaume Català-Mora Guillermo L Chantada Shabana Chaudhry Sonal S Chaugule Argudit Chauhan Bhavna Chawla Violeta S Chernodrinska Faraja S Chiwanga Tsengelmaa Chuluunbat Krzysztof Cieslik Ruellyn L Cockcroft Codruta Comsa Zelia M Correa Maria G Correa Llano Timothy W Corson Kristin E Cowan-Lyn Monika Csóka Xuehao Cui Isac V Da Gama Wantanee Dangboon Anirban Das Sima Das Jacquelyn M Davanzo Alan Davidson Patrick De Potter Karina Q Delgado Hakan Demirci Laurence Desjardins Rosdali Y Diaz Coronado Helen Dimaras Andrew J Dodgshun Craig Donaldson Carla R Donato Macedo Monica D Dragomir Yi Du Magritha Du Bruyn Kemala S Edison I Wayan Eka Sutyawan Asmaa El Kettani Amal M Elbahi James E Elder Dina Elgalaly Alaa M Elhaddad Moawia M Ali Elhassan Mahmoud M Elzembely Vera A Essuman Ted Grimbert A Evina Zehra Fadoo Adriana C Fandiño Mohammad Faranoush Oluyemi Fasina Delia D P G Fernández Ana Fernández-Teijeiro Allen Foster Shahar Frenkel Ligia D Fu Soad L Fuentes-Alabi Brenda L Gallie Moira Gandiwa Juan L Garcia David García Aldana Pascale Y Gassant Jennifer A Geel Fariba Ghassemi Ana V Girón Zelalem Gizachew Marco A Goenz Aaron S Gold Maya Goldberg-Lavid Glen A Gole Nir Gomel Efren Gonzalez Graciela Gonzalez Perez Liudmira González-Rodríguez Henry N Garcia Pacheco Jaime Graells Liz Green Pernille A Gregersen Nathalia D A K Grigorovski Koffi M Guedenon D Sanjeeva Gunasekera Ahmet K Gündüz Himika Gupta Sanjiv Gupta Theodora Hadjistilianou Patrick Hamel Syed A Hamid Norhafizah Hamzah Eric D Hansen J William Harbour M Elizabeth Hartnett Murat Hasanreisoglu Sadiq Hassan Shadab Hassan Stanislava Hederova Jose Hernandez Lorelay Marie Carcamo Hernandez Laila Hessissen Diriba F Hordofa Laura C Huang G B Hubbard Marlies Hummlen Kristina Husakova Allawi N Hussein Al-Janabi Russo Ida Vesna R Ilic Vivekaraj Jairaj Irfan Jeeva Helen Jenkinson Xunda Ji Dong Hyun Jo Kenneth P Johnson William J Johnson Michael M Jones Theophile B Amani Kabesha Rolande L Kabore Swathi Kaliki Abubakar Kalinaki Mehmet Kantar Ling-Yuh Kao Tamar Kardava Rejin Kebudi Tomas Kepak Naama Keren-Froim Zohora J Khan Hussain A Khaqan Phara Khauv Wajiha J Kheir Vikas Khetan Alireza Khodabande Zaza Khotenashvili Jonathan W Kim Jeong Hun Kim Hayyam Kiratli Tero T Kivelä Artur Klett Jess Elio Kosh Komba Palet Dalia Krivaitiene Mariana Kruger Kittisak Kulvichit Mayasari W Kuntorini Alice Kyara Eva S Lachmann Carol P S Lam Geoffrey C Lam Scott A Larson Slobodanka Latinovic Kelly D Laurenti Bao Han A Le Karin Lecuona Amy A Leverant Cairui Li Ben Limbu Quah Boon Long Juan P López Robert M Lukamba Livia Lumbroso Sandra Luna-Fineman Delfitri Lutfi Lesia Lysytsia George N Magrath Amita Mahajan Abdul Rahim Majeed Erika Maka Mayuri Makan Emil K Makimbetov Chatonda Manda Nieves Martín Begue Lauren Mason John O Mason Ibrahim O Matende Miguel Materin Clarissa C D S Mattosinho Marchelo Matua Ismail Mayet Freddy B Mbumba John D McKenzie Aurora Medina-Sanson Azim Mehrvar Aemero A Mengesha Vikas Menon Gary John V D Mercado Marilyn B Mets Edoardo Midena Divyansh K C Mishra Furahini G Mndeme Ahmed A Mohamedani Mona T Mohammad Annette C Moll Margarita M Montero Rosa A Morales Claude Moreira Prithvi Mruthyunjaya Mchikirwa S Msina Gerald Msukwa Sangeeta S Mudaliar Kangwa I Muma Francis L Munier Gabriela Murgoi Timothy G Murray Kareem O Musa Asma Mushtaq Hamzah Mustak Okwen M Muyen Gita Naidu Akshay Gopinathan Nair Larisa Naumenko Paule Aïda Ndoye Roth Yetty M Nency Vladimir Neroev Hang Ngo Rosa M Nieves Marina Nikitovic Elizabeth D Nkanga Henry Nkumbe Murtuza Nuruddin Mutale Nyaywa Ghislaine Obono-Obiang Ngozi C Oguego Andrzej Olechowski Scott C N Oliver Peter Osei-Bonsu Diego Ossandon Manuel A Paez-Escamilla Halimah Pagarra Sally L Painter Vivian Paintsil Luisa Paiva Bikramjit P Pal Mahesh Shanmugam Palanivelu Ruzanna Papyan Raffaele Parrozzani Manoj Parulekar Claudia R Pascual Morales Katherine E Paton Katarzyna Pawinska-Wasikowska Jacob Pe'er Armando Peña Sanja Peric Chau T M Pham Remezo Philbert David A Plager Pavel Pochop Rodrigo A Polania Vladimir G Polyakov Manca T Pompe Jonathan J Pons Daphna Prat Vireak Prom Ignatius Purwanto Ali O Qadir Seema Qayyum Jiang Qian Ardizal Rahman Salman Rahman Jamalia Rahmat Purnima Rajkarnikar Rajesh Ramanjulu Aparna Ramasubramanian Marco A Ramirez-Ortiz Léa Raobela Riffat Rashid M Ashwin Reddy Ehud Reich Lorna A Renner David Reynders Dahiru Ribadu Mussagy M Riheia Petra Ritter-Sovinz Duangnate Rojanaporn Livia Romero Soma R Roy Raya H Saab Svetlana Saakyan Ahmed H Sabhan Mandeep S Sagoo Azza M A Said Rohit Saiju Beatriz Salas Sonsoles San Román Pacheco Gissela L Sánchez Phayvanh Sayalith Trish A Scanlan Amy C Schefler Judy Schoeman Ahad Sedaghat Stefan Seregard Rachna Seth Ankoor S Shah Shawkat A Shakoor Manoj K Sharma Sadik T Sherief Nandan G Shetye Carol L Shields Sorath Noorani Siddiqui Sidi Sidi Cheikh Sónia Silva Arun D Singh Niharika Singh Usha Singh Penny Singha Rita S Sitorus Alison H Skalet Hendrian D Soebagjo Tetyana Sorochynska Grace Ssali Andrew W Stacey Sandra E Staffieri Erin D Stahl Christina Stathopoulos Branka Stirn Kranjc David K Stones Caron Strahlendorf Maria Estela Coleoni Suarez Sadia Sultana Xiantao Sun Meryl Sundy Rosanne Superstein Eddy Supriyadi Supawan Surukrattanaskul Shigenobu Suzuki Karel Svojgr Fatoumata Sylla Gevorg Tamamyan Deborah Tan Alketa Tandili Fanny F Tarrillo Leiva Maryam Tashvighi Bekim Tateshi Edi S Tehuteru Luiz F Teixeira Kok Hoi Teh Tuyisabe Theophile Helen Toledano Doan L Trang Fousseyni Traoré Sumalin Trichaiyaporn Samuray Tuncer Harba Tyau-Tyau Ali B Umar Emel Unal Ogul E Uner Steen F Urbak Tatiana L Ushakova Rustam H Usmanov Sandra Valeina Milo van Hoefen Wijsard Adisai Varadisai Liliana Vasquez Leon O Vaughan Nevyana V Veleva-Krasteva Nishant Verma Andi A Victor Maris Viksnins Edwin G Villacís Chafla Vicktoria Vishnevskia-Dai Tushar Vora Antonio E Wachtel Werner Wackernagel Keith Waddell Patricia D Wade Amina H Wali Yi-Zhuo Wang Avery Weiss Matthew W Wilson Amelia D C Wime Atchareeya Wiwatwongwana Damrong Wiwatwongwana Charlotte Wolley Dod Phanthipha Wongwai Daoman Xiang Yishuang Xiao Jason C Yam Huasheng Yang Jenny M Yanga Muhammad A Yaqub Vera A Yarovaya Andrey A Yarovoy Huijing Ye Yacoub A Yousef Putu Yuliawati Arturo M Zapata López Ekhtelbenina Zein Chengyue Zhang Yi Zhang Junyang Zhao Xiaoyu Zheng Katsiaryna Zhilyaeva Nida Zia Othman A O Ziko Marcia Zondervan Richard Bowman

JAMA Oncol 2020 Feb 27. Epub 2020 Feb 27.

International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale. Read More

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http://dx.doi.org/10.1001/jamaoncol.2019.6716DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047856PMC
February 2020

Short-Term Results Analysis in the Allogenic Transplantation of Limbal Stem Cells Expanded on Amniotic Membrane in Patients with Bilateral Limbal Stem Cell Deficiency.

J Ocul Pharmacol Ther 2020 May 20;36(4):238-246. Epub 2020 Feb 20.

Cell and Tissue Biology, Research Unit, Institute of Ophthalmology, Conde de Valenciana, Mexico City, Mexico.

The objective of this study was to describe the short-term results of allogenic transplantation of limbal stem cells expanded on amniotic membrane for the ocular surface reconstruction. Prospective nonrandomized, nonmasked study in a single ophthalmological center. Ten patients with bilateral total limbal stem cell deficiency (LSCD) were included. Read More

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http://dx.doi.org/10.1089/jop.2019.0147DOI Listing

Long-term visual outcomes of the Boston type I keratoprosthesis in Canada.

Br J Ophthalmol 2020 Feb 17. Epub 2020 Feb 17.

Department of Ophthalmology, Montreal University, Montreal, Quebec, Canada

Background/aims: To evaluate long-term visual outcomes of Boston type I keratoprosthesis (KPro) surgery and identify risk factors for visual failure.

Methods: Single surgeon retrospective cohort study including 85 eyes of 74 patients who underwent KPro implantation to treat severe ocular surface disease, including limbal stem cell deficiency, postinfectious keratitis, aniridia and chemical burns. Procedures were performed at the Centre hospitalier de l'Université de Montréal from October 2008 to May 2012. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315345DOI Listing
February 2020
2.976 Impact Factor

Early Application of Bevacizumab After Sclerocorneal Grafting for Patients With Severe Late-Stage Ocular Chemical Burns.

Cornea 2020 Jun;39(6):754-760

The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre at Sun Yat-sen University, Guangzhou, China.

Purpose: To investigate whether subconjunctival bevacizumab help prevent corneal graft neovascularization and prolong the graft survival of patients with chemical burns.

Methods: We performed a prospective nonrandomized comparative case series study. Twenty-six eyes received subconjunctival bevacizumab (10 mg/0. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002272DOI Listing

Tenonplasty Combined With Amniotic Membrane Transplantation for Patients With Severe Ocular Burns Induced Anterior Segment Necrosis.

J Burn Care Res 2020 May;41(3):668-673

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

This article describes a novel surgical technique for successful repair of intractable corneoscleral necrosis caused by severe ocular burns. In this prospective case series, 19 eyes of 15 consecutive patients with sectional scleral necrosis and persistent corneal epithelial defects were treated with tenonplasty and amniotic membrane transplantation. The main outcome measure was the stability of the ocular surface after reepithelialization and repair of defects. Read More

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http://dx.doi.org/10.1093/jbcr/iraa016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195555PMC

The Indian Health Service Primary Care-Based Teleophthalmology Program for Diabetic Eye Disease Surveillance and Management.

Telemed J E Health 2020 Jan 31. Epub 2020 Jan 31.

Indian Health Service, Phoenix, Arizona.

Historically, fewer than half of American Indians and Alaska Natives (AI/AN) with diabetes received the annual diabetic retinopathy (DR) examination that is considered the minimum standard of care; this rate is similar to that of the general United States (U.S.) population with diabetes. Read More

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http://dx.doi.org/10.1089/tmj.2019.0281DOI Listing
January 2020

A 20-Year Analysis of Adverse Events and Litigation With Light-Based Skin Resurfacing Procedures.

J Oral Maxillofac Surg 2020 Apr 31;78(4):619-628. Epub 2019 Dec 31.

Director, Beau Visage Med Spa and Greater Waterbury OMS, Cheshire, CT; Associate Clinical Professor, Division of Oral and Maxillofacial Surgery, University of Connecticut, Farmington, CT; and Associate Clinical Professor, Department of Surgery, Frank H Netter MD School of Medicine, Quinnipiac University, Hamden, CT. Electronic address:

Purpose: The popularity and availability of facial rejuvenation procedures have increased exponentially during the previous decade. The present study aimed to provide an overview of photorejuvenation and evaluate the complications and litigation related to light-based skin resurfacing procedures.

Materials And Methods: A retrospective study was performed using the US Food and Drug Administration Manufacturer and User Facility Device Experience (MAUDE) registry and the Thomson Reuter Westlaw Edge database from May 1, 1999 to May 1, 2019. Read More

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http://dx.doi.org/10.1016/j.joms.2019.12.012DOI Listing
April 2020
1.280 Impact Factor

Features reported after exposure to automatic dishwashing rinse aids.

Hum Exp Toxicol 2020 Jun 24;39(6):828-833. Epub 2020 Jan 24.

NPIS (Birmingham Unit), City Hospital, Birmingham, UK.

Introduction: Automatic dishwashing rinse aids are drying aids which contain non-ionic surfactants, usually ethoxylated alcohols, typically at concentrations of ≤30%.

Objective: To assess the reported toxicity of rinse aids.

Methods: Telephone enquiries to the UK National Poisons Information Service were analysed from January 2008 to June 2019. Read More

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http://dx.doi.org/10.1177/0960327120901580DOI Listing

Novel ultrasmall nanomicelles based on rebaudioside A: A potential nanoplatform for the ocular delivery of pterostilbene.

Int J Pharm 2020 Mar 15;577:119035. Epub 2020 Jan 15.

Department of Pharmacy, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China; Key Laboratory of Pharmaceutical Research for Metabolic Diseases, Qingdao University of Science and Technology, Qingdao 266042, China. Electronic address:

Rebaudioside A (RA) self-assembled into ultrasmall nanomicelles can be utilized as ocular drug delivery system; nevertheless, the therapeutic efficacy of RA micelles has not evaluated thus far. In this manuscript, the RA micelles are thought to strengthen the therapeutic effects of pterostilbene (Pt). Results showed that Pt can be highly encapsulated into RA micelles with ultrasmall particle sizes (3. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2020.119035DOI Listing

Preparation of placental tissue transplants and their application in skin wound healing and chosen skin bullous diseases - Stevens-Johnson syndrome and toxic epidermal necrolysis treatment.

Int Wound J 2020 Apr 15;17(2):491-507. Epub 2020 Jan 15.

Department of Descriptive and Topographic Anatomy, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Zabrze, Poland.

Unique properties of amniotic membrane make it a promising source for tissue engineering and a clinically useful alternative for patients suffering from chronic wounds including, for example, ulcers, burns, ocular surface damages and wounds occurring in the course of bullous diseases like stevens-johnson syndrome and toxic epidermal necrolysis. Its use has many advantages over standard wound care, as it contains pluripotent cells, nutrients, anti-fibrotic and anti-inflammatory cytokines, growth factors and extracellular matrix (ECM) proteins. Placental tissues can be prepared as a medical component, an advanced therapy medicinal product or a tissue graft. Read More

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http://dx.doi.org/10.1111/iwj.13305DOI Listing

[Clinical observation of autologous simple limbal epithelial transplantation for unilateral limbal stem cell deficiency].

Zhonghua Yan Ke Za Zhi 2019 Dec;55(12):923-927

Beijing Tongren Eye Center, Being Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmol & Visual Sciences, Beijing 100730, China.

To discuss effect of autologous simple limbal epithelial transplantation (SLET) performed for unilateral limbal stem cell deficiency (LSCD). Retrospective case study. In this retrospective study, records of 7 patients (7 eyes) who had undergone autologous SLET for unilateral LSCD, with a minimum of 6 months of follow-up, were reviewed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.12.010DOI Listing
December 2019

A double masked randomised 4-week, placebo-controlled study in the USA, Thailand and Taiwan to compare the efficacy of oral valganciclovir and topical 2% ganciclovir in the treatment of cytomegalovirus anterior uveitis: study protocol.

BMJ Open 2019 Dec 19;9(12):e033175. Epub 2019 Dec 19.

Proctor Foundation, University of California San Francisco, San Francisco, California, USA

Introduction: Cytomegalovirus (CMV) anterior uveitis is a recognised cause of anterior uveitis in immunocompetent patients and is preventable cause of vision loss. Ocular sequelae include corneal endothelial damage which can cause corneal oedema and failure, as well as glaucoma. Recurrences of inflammation are common and therefore patients are often exposed to long-term therapy. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-033175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6937053PMC
December 2019

Expression of Murine CD80 by Herpes Simplex Virus 1 in Place of Latency-Associated Transcript (LAT) Can Compensate for Latency Reactivation and Anti-apoptotic Functions of LAT.

J Virol 2020 Feb 28;94(6). Epub 2020 Feb 28.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, Los Angeles, California, USA

High rates of wild-type (WT) herpes simplex virus 1 (HSV-1) latency reactivation depend on the anti-apoptotic activities of latency-associated transcript (LAT). Replacing LAT with the baculovirus inhibitor of apoptosis protein (cpIAP) or cellular FLIP (FLICE-like inhibitory protein) gene restored the WT latency reactivation phenotype to that of a LAT-minus [LAT(-)] virus, while similar recombinant viruses expressing interleukin-4 (IL-4) or interferon gamma (IFN-γ) did not. However, HSV-1 recombinant virus expressing cpIAP did not restore all LAT functions. Read More

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http://dx.doi.org/10.1128/JVI.01798-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7158736PMC
February 2020
4.439 Impact Factor

Multidisciplinary Treatment to Restore Vision in Ocular Burns.

J Burn Care Res 2019 Dec 6. Epub 2019 Dec 6.

Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston, MA, USA.

Introduction: Periorbital burns generate contraction and distortion of periorbital soft tissue, causing eyelid malfunction, further contributing to loss of vision from corneal scarring or perforation. We present our multidisciplinary algorithm to restore vision in patients with burn-related bilateral corneal blindness with light perception.

Methods: Chart review was performed for 4 consecutive burn patients requiring periocular reconstruction and keratoprosthesis. Read More

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http://dx.doi.org/10.1093/jbcr/irz201DOI Listing
December 2019

Ocular chemical burns in the workplace: Epidemiological characteristics.

Burns 2019 Nov 29. Epub 2019 Nov 29.

Universidad Francisco de Vitoria, Faculty of Medicine, Pozuelo de Alarcón, Madrid, Spain. Electronic address:

Background: Epidemiological studies focusing on occupational pathologies can be an important medium through which to bring about change with respect to workplace accidents, both in terms of prevention planning and management as well as the appropriate care following an accident. Ocular chemical burns benefit from urgent attention as, if not treated early and appropriately, the tissue of the eye and its functionality can be seriously compromised. The objective of this study was to collate epidemiological data on workplace ocular chemical burns which could in turn serve to identify key action points in terms of occupational health. Read More

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http://dx.doi.org/10.1016/j.burns.2019.11.007DOI Listing
November 2019

Ophthalmological evaluation of facial burns in a regional burns centre.

Burns 2019 Nov 23. Epub 2019 Nov 23.

University Hospital Birmingham NHS Foundation Trust, Burns Unit, Queen Elizabeth Hospital Birmingham, University Hospital Birmingham NHS Foundation Trust, Mindelsohn Way, Birmingham B15 2TH, United Kingdom; Birmingham City University, Birmingham, B4 7BD, United Kingdom; Cardiff University, Cardiff CF10 3AT, United Kingdom. Electronic address:

Ocular burns are ophthalmological emergencies, owing to their potentially serious visual complications. Prompt recognition, irrigation and comprehensive examination including fluorescein staining is recommended to optimise outcomes. Burns standards recommend ophthalmological services be available in a 'timely' manner. Read More

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http://dx.doi.org/10.1016/j.burns.2019.10.025DOI Listing
November 2019

The Use of Umbilical Amnion for Conjunctival Socket, Fornix, and Eyelid Margin Reconstruction.

Ophthalmic Plast Reconstr Surg 2019 Nov 21. Epub 2019 Nov 21.

Department of Ophthalmology and Visual Sciences, W. K Kellogg Eye Center, Ann Arbor, Michigan, U.S.A.

Purpose: To describe outcomes using umbilical amnion for conjunctival fornix, socket, and eyelid margin reconstruction.

Methods: A medical record review was performed to identify patients who had received umbilical amnion over a 2-year period in their department. Patient demographics, disease etiology, and data regarding surgical outcomes were collected. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001555DOI Listing
November 2019

Shedding light on a potential hazard: Dental light-curing units.

J Am Dent Assoc 2019 12;150(12):1051-1058

Background: Dental light-curing units (LCUs) are powerful sources of blue light that can cause soft-tissue burns and ocular damage. Although most ophthalmic research on the hazards of blue light pertains to low levels from personal electronic devices, computer monitors, and light-emitting diode light sources, the amount of blue light emitted from dental LCUs is much greater and may pose a "blue light hazard."

Methods: The authors explain the potential risks of using dental LCUs, identify the agencies that provide guidelines designed to protect all workers from excessive exposure to blue light, discuss the selection of appropriate eye protection, and provide clinical tips to ensure eye safety when using LCUs. Read More

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http://dx.doi.org/10.1016/j.adaj.2019.08.012DOI Listing
December 2019

Design and Outcomes of a Novel Keratoprosthesis: Addressing Unmet Needs in End-Stage Cicatricial Corneal Blindness.

Cornea 2020 Apr;39(4):484-490

Disruptive Technology Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA.

Purpose: The most commonly applied prosthetic devices for corneal blindness in the setting of severe cicatricial keratoconjunctivitis are the Boston keratoprosthesis type II and the modified osteo-odonto-keratoprosthesis, with these requiring either normal eyelid skin or a healthy cuspid tooth, respectively. For patients with neither attribute, we developed a new keratoprosthesis device combining positive aspects of both Boston keratoprosthesis type II and modified osteo-odonto-keratoprosthesis, which we have named the "Lux."

Methods: Short-term postoperative outcomes for the Lux keratoprosthesis, best-corrected visual acuity (BCVA), device retention, and complications, were examined in a retrospective case series of 9 eyes of 9 patients implanted at 4 centers. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002207DOI Listing

The proteolytic fraction from Vasconcellea cundinamarcensis accelerates wound healing after corneal chemical burn in rabbits.

Burns 2019 Nov 10. Epub 2019 Nov 10.

Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil. Electronic address:

Introduction: Chemical ocular burns are among the most frequently eye-related injuries, which require immediate and intensive evaluation and care since they may lead to potential complications such as superinfection, corneal perforation, and blindness.Vasconcellea cundinamarcensis, a species from Caricaceae family, contains highly active proteolytic enzymes in its latex that show healing activity in animal models bearing lesions of different etiologies.

Methods: We evaluate the ocular toxicity of the proteolytic fraction from V. Read More

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http://dx.doi.org/10.1016/j.burns.2019.10.005DOI Listing
November 2019

Correlation analysis of the clinical features and prognosis of acute ocular burns-exploration of a new classification scheme.

Graefes Arch Clin Exp Ophthalmol 2020 Jan 12;258(1):147-155. Epub 2019 Nov 12.

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Qingdao, China.

Purpose: To explore a new classification scheme for acute ocular burns.

Methods: Medical records of 345 patients (450 eyes) with acute ocular burns treated at Shandong Eye Institute between January 2013 and January 2018 with a 12-month minimum follow-up were retrospectively reviewed. A total of 8 parameters in the acute phase were evaluated and graded on a scale from 0 to 3 according to their severity. Read More

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http://dx.doi.org/10.1007/s00417-019-04525-6DOI Listing
January 2020

Complete Anterior Capsule Phimosis following Cataract Surgery in a Patient with a History of Retinopathy of Prematurity, Nystagmus, and a Narrow Angle.

Case Rep Ophthalmol 2019 May-Aug;10(2):274-280. Epub 2019 Aug 13.

John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.

The authors present a case of complete anterior capsule phimosis and vision decline which developed 4 weeks postoperatively in the right eye after uncomplicated cataract surgery. Prior ocular history included retinopathy of prematurity in both eyes, acute angle closure glaucoma in the left eye, prophylactic laser peripheral iridotomy for a narrow angle in the right eye, and nystagmus in both eyes. This condition was addressed by surgically releasing the anterior capsule with microscissors to open the pupillary space which had been completely obscured by the anterior capsule, also causing the haptics of the 1-piece intraocular lens to deform. Read More

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http://dx.doi.org/10.1159/000502282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6760351PMC

Irrigation with phosphate-buffered saline causes corneal calcification during treatment of ocular burns.

Burns 2019 12 16;45(8):1871-1879. Epub 2019 Oct 16.

Aachen Centre Of Technology Transfer In Ophthalmology (ACTO e.V.), An-Institute, RWTH Aachen University, ACTO e.V. Karlsburgweg 9, D 52070 Aachen, Germany; Department of Ophthalmology, Kliniken der Stadt Köln, D 51109 Cologne, Ostmerheimer Str. 200, Germany.

Corneal calcification is a vision-threatening manifestation of calcium containing agents in ocular burn. As we previously reported, our interest was sparked by a particular discrepancy of a case: A patient treated for a non-calcium containing agent in eye burn from exposure to an alkaline mixture of NaOH and KOH, who unexpectedly developed corneal calcification. This current study aims to elucidate whether the 2min lasting irrigation with a phosphate-buffered saline itself, regardless of rinsing regimen, triggers corneal calcification. Read More

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http://dx.doi.org/10.1016/j.burns.2019.04.022DOI Listing
December 2019

CD80 Plays a Critical Role in Increased Inflammatory Responses in Herpes Simplex Virus 1-Infected Mouse Corneas.

J Virol 2020 01 6;94(2). Epub 2020 Jan 6.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, CSMC-SSB3, Los Angeles, California, USA

We recently reported that herpes simplex virus 1 (HSV-1) infection suppresses CD80 but not CD86 expression and This suppression required the HSV-1 ICP22 gene. We also reported that overexpression of CD80 by HSV-1 exacerbated corneal scarring in BALB/c mice. We now show that this recombinant virus (HSV-CD80) expressed high levels of CD80 both in cultured rabbit skin cells and in infected mouse corneas. Read More

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http://dx.doi.org/10.1128/JVI.01511-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6955247PMC
January 2020

Within-subject variability in human retinal nerve fiber bundle width.

PLoS One 2019 16;14(10):e0223350. Epub 2019 Oct 16.

School of Optometry, Indiana University, Bloomington, Indiana, United States of America.

With the growing availability of high-resolution imaging there has been increased interest in developing new metrics for integrity of the retinal nerve fiber layer. In particular, it has been suggested that measurement of width of retinal nerve fiber bundles (RNFBs) may be useful in glaucoma, due to low between-subject variability in mean RNFB width. However, there have also been reports of substantial within-subject variability in the width of individual RNFBs. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223350PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6795422PMC
March 2020
1 Read

Thermal burns of the spectacle associated with supplementary heating in native New Zealand geckos.

N Z Vet J 2020 Mar 16;68(2):126-133. Epub 2019 Oct 16.

Wildbase, School of Veterinary Science, Massey University, Palmerston North, New Zealand.

Gradual onset of ocular opacity was observed in three gold-striped geckos () and five Pacific geckos () held in two adjacent terrariums in a zoological institution located in the North Island of New Zealand. Ultraviolet light and heat had been provided for the previous 3-4 years by a fluorescent bulb, but in the last 4 weeks of winter a ceramic heat bulb had been added, situated 10 cm above the upper mesh of the cage All eight geckos presented with mostly bilateral lesions of varying severity confined to the central or upper quadrant of the spectacles. These lesions ranged from variable areas of opacity within the stroma of the spectacle to similarly distributed ulcers of the surface epithelium of both spectacles. Read More

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http://dx.doi.org/10.1080/00480169.2019.1674747DOI Listing

Primary vitreoretinal lymphoma: empowering our clinical suspicion.

Curr Opin Ophthalmol 2019 Nov;30(6):491-499

Francis I. Proctor Foundation.

Purpose Of Review: Vitreoretinal lymphoma (VRL) is well known as a masquerade syndrome. However, delays in diagnosis are common particularly because of the small volume of tissue that is used for investigative studies. We outline the current diagnostic tests available to clinicians and provide a glimpse of possible future novel diagnostics. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000620DOI Listing
November 2019

IgA Nephropathy-Associated Uveitis: A Case Presentation.

Ocul Immunol Inflamm 2019 Oct 3:1-4. Epub 2019 Oct 3.

Francis I. Proctor Foundation, University of California San Francisco , San Francisco , California , USA.

: To describe a case of bilateral panuveitis in the setting of IgA nephropathy. : Retrospective review of clinical records, fundus, and optical coherence tomographic (OCT) images, and fluorescein angiography. : A 36-year-old female presented with IgA nephropathy and contemporaneous ocular manifestations of one-year duration. Read More

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http://dx.doi.org/10.1080/09273948.2019.1651873DOI Listing
October 2019
1 Read

East London deliberate corrosive fluid injuries.

Eye (Lond) 2020 Apr 25;34(4):733-739. Epub 2019 Sep 25.

Department of Ophthalmology, The Royal London Hospital, Barts Health NHS Trust, Whitechapel Road, London, E1 1BB, UK.

Objectives: The aims of this case series are to (1) highlight the incidence of deliberate corrosive fluid injuries (DCFI) in East London; (2) ascertain the types of substances used; and (3) grade the resulting ocular surface burns using two validated grading systems.

Methods: The Metropolitan Police 2017 Freedom of Information (FOI) requests were reviewed for DCFI. We retrospectively reviewed patient records between October 2016 and 2017 from local A&E departments for DCFI. Read More

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http://dx.doi.org/10.1038/s41433-019-0593-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093456PMC
April 2020
1 Read

A rabbit model for assessing symblepharon after alkali burn of the superior conjunctival sac.

Sci Rep 2019 09 25;9(1):13857. Epub 2019 Sep 25.

Aier School of Ophthalmology, Central South University, Changsha, Hunan, China.

Symblepharon due to chemical burns affects ocular surface health, and there are currently no satisfactory treatments. To improve our understanding of symblepharon, an appropriate animal model is urgently needed. We established a rabbit model of superior conjunctival sac alkaline burn to evaluate symblepharon severity. Read More

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http://dx.doi.org/10.1038/s41598-019-50286-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761117PMC
September 2019
1 Read

Acute surgical vs non-surgical management for ocular and peri-ocular burns: a systematic review and meta-analysis.

Burns Trauma 2019 2;7:25. Epub 2019 Sep 2.

1Department of Plastic and Reconstructive Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD USA.

Background: Burn-related injury to the face involving the structures of the eyes, eyelids, eyelashes, and/or eyebrows could result in multiple reconstructive procedures to improve functional and cosmetic outcomes, and correct complications following poor acute phase management. The objective of this article was to evaluate if non-surgical or surgical interventions are best for acute management of ocular and/or peri-ocular burns.

Methods: This systematic review and meta-analysis compared 272 surgical to 535 non-surgical interventions within 1 month of patients suffering burn-related injuries to 465 eyes, 253 eyelids, 90 eyelashes, and 0 eyebrows and evaluated associated outcomes and complications. Read More

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http://dx.doi.org/10.1186/s41038-019-0161-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6717987PMC
September 2019
2 Reads

Toxic epidermal necrolysis (TEN): Acute complications and long-term sequelae management in a multidisciplinary follow-up.

J Plast Reconstr Aesthet Surg 2020 Feb 8;73(2):319-327. Epub 2019 Aug 8.

Department of Plastic Surgery and Burns Unit, Cruces University Hospital, Plaza de Cruces, S/N, 48903 Baracaldo, Vizcaya, Spain.

Background: Toxic epidermal necrolysis (TEN) is a devastating exfoliative disorder with life-changing complications. This study aimed to identify acute complications and long-term sequelae of TEN and to highlight the importance of a multidisciplinary management follow-up.

Methods: A 19-year (1998-2016) retrospective review of all patients with TEN admitted to Cruces University Hospital´s Burns Unit was performed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S17486815193034
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http://dx.doi.org/10.1016/j.bjps.2019.07.015DOI Listing
February 2020
4 Reads

[Qualitative research on psychological experience of parents of burned infants during hospitalization].

Authors:
C J Zeng Y Zhang

Zhonghua Shao Shang Za Zhi 2019 Aug;35(8):595-598

Department of Burns and Plastic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

To understand the psychological experience of parents of burned infants during hospitalization, and to provide basis for formulating feasible targeted treatment and nursing programs. The mother or father of 15 burned infants admitted to the Department of Burns and Plastic Surgery of Ruijin Hospital of Shanghai Jiao Tong University School of Medicine from June to October 2017 were interviewed about their psychological experience during hospitalization of their burned infants one day before the children were expected to be discharged, using the phenomenological method of qualitative research. Data were collected through face to face, semi-structured, and in-depth interviews, and the Colaizzi's analysis method was applied to analyze, induce, and refine themes of interview data. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1009-2587.2019.08.007DOI Listing
August 2019
2 Reads

Glaucoma After Corneal Trauma or Surgery-A Rapid, Inflammatory, IOP-Independent Pathway.

Cornea 2019 Dec;38(12):1589-1594

Cornea Service, Glaucoma Service and Boston Keratoprosthesis Laboratory, Massachusetts Eye and Ear and Schepens Eye Research Institute, Harvard Medical School, Boston, MA.

Purpose: To review clinical aspects and cellular and molecular steps in the development of long-term glaucoma after corneal surgery or acute trauma-especially the pivotal role of tumor necrosis factor alpha (TNF-α), the rapidity of the secondary damage to the retinal ganglion cells, and the clinical promise of early antiinflammatory intervention.

Methods: A series of laboratory studies on post-injury and post-surgery glaucoma have been compared to clinical outcome studies on the subject, focusing particularly on the vulnerability of the retinal ganglion cells. Alkali burn to the cornea of mice and rabbits served as the main experimental model. Read More

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http://dx.doi.org/10.1097/ICO.0000000000002106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830965PMC
December 2019
1 Read

Nursing problems in patients with toxic epidermal necrolysis and Stevens-Johnson syndrome in a Dutch burn centre: A 30-year retrospective study.

Burns 2019 11 3;45(7):1625-1633. Epub 2019 Aug 3.

Burn Centre, Maasstad Hospital, P.O. Box 9100, 3007 AC Rotterdam, The Netherlands; Association of Dutch Burn Centres, P.O. Box 1015, 1940 EA Beverwijk, The Netherlands. Electronic address:

Objective: Multiple studies have been published on toxic epidermal necrolysis (TEN) and Stevens-Johnsen syndrome (SJS). Nursing care is an important part of the treatment of TEN patients. Unfortunately, limited information on nursing in TEN/SJS patients has been published in the current literature. Read More

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http://dx.doi.org/10.1016/j.burns.2019.07.004DOI Listing
November 2019
5 Reads

Loss of ICP22 in HSV-1 Elicits Immune Infiltration and Maintains Stromal Keratitis Despite Reduced Primary and Latent Virus Infectivity.

Invest Ophthalmol Vis Sci 2019 08;60(10):3398-3406

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, Los Angeles, California, United States.

Purpose: We previously have reported that ICP22, an immediate early gene of herpes simplex virus type 1 (HSV-1), binds to the CD80 promoter to suppress CD80 expression in antigen-presenting cells, leading to reduced T-cell function and protection. In contrast, overexpression of CD80 exacerbates corneal scarring (CS) in ocularly infected mice. In this study we tested the hypothesis that the absence of ICP22 could increase disease severity. Read More

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http://dx.doi.org/10.1167/iovs.19-27701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6685448PMC
August 2019
7 Reads