1,495 results match your criteria Burns Ocular


Corneal Endothelial Decompensation after Ocular Chemical Burn: Description of a New Finding.

Klin Monbl Augenheilkd 2019 Apr 18;236(4):371-376. Epub 2019 Apr 18.

Augenklinik, Universitatsspital Basel, Basel, Switzerland.

Background: Ocular chemical burn is an ophthalmological emergency. Therefore, chemical injuries should be promptly addressed in order to initiate the appropriate treatment as soon as possible and optimize the visual prognosis. We present a retrospective study of ten cases with ocular chemical burn including one with superglue and one with a liquid plaster material injury and describe their clinical course. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0857-6538
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http://dx.doi.org/10.1055/a-0857-6538DOI Listing
April 2019
1 Read

The impact of assault by vitriolage on quality of life: Integrative review.

J Adv Nurs 2019 Apr 5. Epub 2019 Apr 5.

Institute of Clinical Sciences, University of Birmingham, Birmingham, UK.

Aims: To analyse quality of life post vitriolage and explore factors affecting an individual's everyday functioning after an acid attack.

Design: Integrative review.

Data Sources: Articles (N=570) retrieved from Medline, CINAHL Embase and Psychinfo between 2004-2017. Read More

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http://dx.doi.org/10.1111/jan.14021DOI Listing
April 2019
1 Read

Philadelphia Telemedicine Glaucoma Detection and Follow-up Study: Intraocular Pressure Measurements Found in a Population at High Risk for Glaucoma.

J Glaucoma 2019 Apr;28(4):294-301

Wills Eye Hospital, Glaucoma Research Center.

Precis: Intraocular pressure (IOP) measurements, when used during telemedicine eye screening alongside nonmydriatic fundus photography, were shown to improve the likelihood of accurate glaucoma and glaucoma-related diagnoses at the follow-up eye examination.

Purpose: To determine if IOP measurements, used as an adjunct to nonmydriatic fundus photography, are useful in glaucoma telemedicine screening.

Materials And Methods: A total of 902 high-risk individuals were screened for glaucoma at 7 primary care practices and 4 Federally Qualified Health Centers using telemedicine. Read More

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http://dx.doi.org/10.1097/IJG.0000000000001207DOI Listing
April 2019
3 Reads

[Lacrimal Stenosis after Chemical and Thermal Ocular Burns].

Klin Monbl Augenheilkd 2019 Apr 2. Epub 2019 Apr 2.

Universitätsklinik und Poliklinik für Augenheilkunde, Universitätsklinikum Halle.

Background: Chemical or thermal burns of the ocular surface are an urgent ophthalmologic emergency. Consecutive epiphora causes a high level of suffering for affected patients.

Method: Based on a review of current literature, and our own longstanding experiences, recommendations are given on the treatment of secondary lacrimal duct obstruction due to ocular surface damage after chemical or thermal burns. Read More

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http://dx.doi.org/10.1055/a-0808-4909DOI Listing

Inadvertent macular burns and consecutive psychological depression secondary to Alexandrite laser epilation: A case report.

Authors:
Lokman Balyen

Saudi J Ophthalmol 2019 Jan-Mar;33(1):105-108. Epub 2018 Apr 11.

Kafkas University, Faculty of Medicine, Department of Ophthalmology, Kars, Turkey.

Unwanted hair is an important aesthetic problem in many cultures. Laser epilation devices have become commonly available at the present time. Nowadays, laser hair removal is widely practiced as a cosmetic procedure, however, some ocular complications may occur. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13194534183010
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http://dx.doi.org/10.1016/j.sjopt.2018.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424673PMC
April 2018
3 Reads

Adherence to Treatment and Follow-Up in Patients with Severe Chemical Eye Burns.

Ophthalmol Ther 2019 Mar 13. Epub 2019 Mar 13.

Moorfields Eye Hospital NHS Foundation Trust, London, UK.

Introduction: To investigate the demographics, acute management and compliance rates of severe chemical eye burn cases that presented to the largest eye hospital in the United Kingdom (UK).

Methods: All patients presenting to the Moorfields Eye Hospital emergency department are registered on the electronic patient administration system (PAS). A search of the PAS for patients assigned a preset diagnosis of 'chemical injury' was performed for the period from 1 January to 31 March 2016. Read More

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http://dx.doi.org/10.1007/s40123-019-0173-yDOI Listing
March 2019
3 Reads

LAT inhibits apoptosis via downregulation of components of type I IFN pathway during latent HSV-1 ocular infection.

J Virol 2019 Feb 27. Epub 2019 Feb 27.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns and Allen Research Institute, Los Angeles, California

Herpes Simplex Virus type 1 (HSV-1) latency associated transcript (LAT) has been shown to inhibit apoptosis via inhibiting activation of pro-apoptotic caspases. However, the mechanism of LAT control of apoptosis is unclear, because LAT is not known to encode a functional protein, and the LAT transcript is found largely in the nucleus. We hypothesized that LAT inhibits apoptosis by regulating expression of genes that control apoptosis. Read More

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http://dx.doi.org/10.1128/JVI.00103-19DOI Listing
February 2019
2 Reads
4.439 Impact Factor

Novel window for cancer nanotheranostics: non-invasive ocular assessments of tumor growth and nanotherapeutic treatment efficacy .

Biomed Opt Express 2019 Jan 11;10(1):151-166. Epub 2018 Dec 11.

EyePod Small Animal Ocular Imaging Laboratory, University of California, Davis, CA 95616, USA.

In cancer research there is a fundamental need for animal models that allow the longitudinal visualization and quantification of tumor development, nanotherapeutic delivery, the tumor microenvironment including blood vessels, macrophages, fibroblasts, immune cells, and extracellular matrix, and the tissue response to treatment. To address this need, we developed a novel mouse ocular xenograft model. Green fluorescent protein (GFP) expressing human glioblastoma cells (between 500 and 10,000) were implanted into the subretinal space of immunodeficient mice (56 eyes). Read More

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http://dx.doi.org/10.1364/BOE.10.000151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363190PMC
January 2019

Philadelphia Telemedicine Glaucoma Detection and Follow-up Study: confirmation between eye screening and comprehensive eye examination diagnoses.

Br J Ophthalmol 2019 Feb 15. Epub 2019 Feb 15.

Glaucoma Service, Wills Eye Hospital, Philadelphia, Pennsylvania, USA.

Aims: To evaluate agreement between ocular findings of a telemedicine eye screening (visit 1) with diagnoses of a comprehensive eye examination (visit 2).

Methods: A primary care practice (PCP)-based telemedicine screening programme incorporating fundus photography, intraocular pressure (IOP) and clinical information was conducted. Eligible individuals were African American, Hispanic/Latino or Asian over the age of 40; Caucasian individuals over age 65; and adults of any ethnicity over age 40 with a family history of glaucoma or diabetes. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313451DOI Listing
February 2019
6 Reads

Staged ocular fornix reconstruction for glaucoma drainage device under neoconjunctiva at the time of Boston type 1 Keratoprosthesis implantation.

Ocul Surf 2019 Feb 8. Epub 2019 Feb 8.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL, United States.

Purpose: Glaucoma is the leading cause of vision loss in eyes with Boston Keratoprosthesis (KPro). Glaucoma drainage devices (GDDs) have been shown to be effective in controlling glaucoma with KPro. Cicatricial conjunctival disease with forniceal shortening is a major challenge and limitation to the use of GDD. Read More

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http://dx.doi.org/10.1016/j.jtos.2019.01.010DOI Listing
February 2019
2 Reads

The clinical toxicology of sodium hypochlorite.

Clin Toxicol (Phila) 2019 Jan 28:1-9. Epub 2019 Jan 28.

a National Poisons Centre , University of Otago , Dunedin , New Zealand.

Introduction: Sodium hypochlorite is used as a bleaching and disinfecting agent and is commonly found in household bleach.

Objective: The objective is to review critically the epidemiology, mechanisms of toxicity, clinical features, diagnosis, and management of hypochlorite poisoning.

Methods: PubMed was searched from January 1950 to June 2018 using the terms "Hypochlorite", "Sodium Hypochlorite", "Sodium Oxychloride", "Hypochlorous Acid", "Bleach", "Chlorine Bleach", in combination with the keywords "poisoning", "poison", "toxicity", "ingestion", "adverse effects", "overdose", and "intoxication". Read More

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http://dx.doi.org/10.1080/15563650.2018.1543889DOI Listing
January 2019
3 Reads

Matriderm and Split Skin Grafting for Full-Thickness Pediatric Facial Burns.

J Burn Care Res 2019 Feb;40(2):251-254

The Children's Hospital at Westmead, Westmead, New South Wales, Australia.

Facial burns remain a complex reconstructive challenge. Achieving the plastic surgical goals of restoring form and function is difficult in these cases, with poor cosmetic results, reduced facial animation, and oral and ocular contractures a common result. In recent years, the use of dermal substitutes in combination with skin grafts has shown promising results in complex burn reconstruction. Read More

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http://dx.doi.org/10.1093/jbcr/irz006DOI Listing
February 2019
1 Read

Corneal Wound Healing Effects of Mesenchymal Stem Cell Secretome Delivered Within a Viscoelastic Gel Carrier.

Stem Cells Transl Med 2019 Jan 15. Epub 2019 Jan 15.

Department of Ophthalmology, Byers Eye Institute at Stanford University School of Medicine, Palo Alto, California, USA.

Severe corneal injuries often result in permanent vision loss and remain a clinical challenge. Human bone marrow derived mesenchymal stem cells (MSCs) and their secreted factors (secretome) have been studied for their antiscarring, anti-inflammatory, and antiangiogeneic properties. We aimed to deliver lyophilized MSC secretome (MSC-S) within a viscoelastic gel composed of hyaluronic acid (HA) and chondroitin sulfate (CS) as a way to enhance corneal re-epithelialization and reduce complications after mechanical and chemical injuries of the cornea. Read More

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http://doi.wiley.com/10.1002/sctm.18-0178
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http://dx.doi.org/10.1002/sctm.18-0178DOI Listing
January 2019
12 Reads

Scleral Ischemia in Acute Ocular Chemical Injury: Long-Term Impact on Rehabilitation With Limbal Stem Cell Therapy.

Cornea 2019 Feb;38(2):198-202

Dr. Shroff's Charity Eye Hospital, Daryaganj, New Delhi, India.

Purpose: This study describes the impact of scleral ischemia on globe survival in cases of acute chemical injury and the outcome of limbal stem cell transplant in these eyes.

Methods: This is a single-center, retrospective case study that reviews outcomes in all patients with acute chemical injury of grades IV and above who presented within 6 weeks from injury. The period of the study is between May 2012 and May 2017. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001807DOI Listing
February 2019
2 Reads

Commentary: Assessment of limbal ischemia in ocular burns.

Indian J Ophthalmol 2019 01;67(1):37

Department of Cornea and Refractive Services, Aravind Eye Hospital, Madurai, Tamil Nadu, India.

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http://dx.doi.org/10.4103/ijo.IJO_1432_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324105PMC
January 2019

Limbal ischemia: Reliability of clinical assessment and implications in the management of ocular burns.

Indian J Ophthalmol 2019 Jan;67(1):32-36

Brien Holden Eye Research Center, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Hyderabad, Telangana, India.

Purpose: Limbal ischemia is an important prognostic factor in the management of ocular burns. In this study, we evaluated the reliability of clinically assessing limbal ischemia among ophthalmic professionals.

Methods: This study included 111 ophthalmic professionals who were shown 12 diffuse illumination color slit-lamp photographs of eyes with recent chemical injuries. Read More

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http://www.ijo.in/text.asp?2019/67/1/32/243760
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http://dx.doi.org/10.4103/ijo.IJO_945_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324115PMC
January 2019
18 Reads

Prescribing lessons from an ocular chemical injury: Vitaros inadvertently dispensed instead of VitA-POS.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Department of Ophthalmology, Tennent Institute of Ophthalmology, Glasgow, UK.

We wish to report an ocular chemical injury caused by inadvertent dispensing and administration of an erectile dysfunction cream (Vitaros) instead of an ocular lubricant (VitA-POS) to highlight this potential source of error. Prescribing errors are common, and medications with similar names/packaging increase risk. However, it is unusual in this case that no individual (including the patient, general practitioner or dispensing pharmacist) questioned erectile dysfunction cream being prescribed to a female patient, with ocular application instructions. Read More

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http://www.bmj.com/lookup/doi/10.1136/bcr-2018-227468
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http://dx.doi.org/10.1136/bcr-2018-227468DOI Listing
December 2018
12 Reads

Monocyte infiltration rather than microglia proliferation dominates the early immune response to rapid photoreceptor degeneration.

J Neuroinflammation 2018 Dec 15;15(1):344. Epub 2018 Dec 15.

Department of Cell Biology and Human Anatomy, University of California, Davis, 1 Shields Avenue, Davis, CA, 95616, USA.

Background: Activation of resident microglia accompanies every known form of neurodegeneration, but the involvement of peripheral monocytes that extravasate and rapidly transform into microglia-like macrophages within the central nervous system during degeneration is far less clear.

Methods: Using a combination of in vivo ocular imaging, flow cytometry, and immunohistochemistry, we investigated the response of infiltrating cells in a light-inducible mouse model of photoreceptor degeneration.

Results: Within 24 h, resident microglia became activated and began migrating to the site of degeneration. Read More

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http://dx.doi.org/10.1186/s12974-018-1365-4DOI Listing
December 2018
1 Read

Ocular Considerations in Face Transplantation: Report of 2 Cases and Review of the Literature.

Ophthalmic Plast Reconstr Surg 2018 Dec 7. Epub 2018 Dec 7.

The Hansjörg Wyss Department of Plastic Surgery and.

Purpose: Periorbital injuries are common in face transplantation (FT) candidates. It is therefore essential that the ophthalmologist play a central role in the multidisciplinary treatment of these patients. In this study, the authors perform a comprehensive review of all procedures involving periorbital components, provide an update for the ophthalmology community regarding the current state of the field, and present 2 cases. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001296DOI Listing
December 2018
18 Reads

Retinal burns from laser pointers: a risk in children with behavioural problems.

Eye (Lond) 2019 03 13;33(3):492-504. Epub 2018 Dec 13.

Department of Ophthalmology, Bolton Hospitals NHS Foundation Trust, Bolton, UK.

Objective: To explore self-inflicted retinal burns from laser pointers in children.

Methods: Literature review of laser pointer retinal injuries in childhood and online survey of UK Consultant Ophthalmologists. A cohort of local children with self-inflicted injury is described. Read More

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http://dx.doi.org/10.1038/s41433-018-0276-zDOI Listing
March 2019
1 Read

Non-GVHD ocular complications after hematopoietic cell transplantation: expert review from the Late Effects and Quality of Life Working Committee of the CIBMTR and Transplant Complications Working Party of the EBMT.

Bone Marrow Transplant 2019 Feb 27. Epub 2019 Feb 27.

Department of Ophthalmology, Hospital Universitario Puerta de Hierro, Madrid, Spain.

Non-graft-vs.-host disease (non-GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT), but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplant physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Read More

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http://dx.doi.org/10.1038/s41409-018-0339-6DOI Listing
February 2019
7 Reads

Non-Graft-versus-Host Disease Ocular Complications after Hematopoietic Cell Transplantation: Expert Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society for Blood and Marrow Transplantation.

Biol Blood Marrow Transplant 2018 Dec 3. Epub 2018 Dec 3.

Department of Ophthalmology, Puerta de Hierro Majadahonda University Hospital, Madrid, Spain.

Non-graft-versus-host disease (GVHD) ocular complications are generally uncommon after hematopoietic cell transplantation (HCT) but can cause prolonged morbidity affecting activities of daily living and quality of life. Here we provide an expert review of non-GVHD ocular complications in a collaboration between transplantation physicians and ophthalmologists through the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and the Transplant Complications Working Party of the European Society of Blood and Marrow Transplantation. Complications discussed in this review include cataracts, glaucoma, ocular infections, ocular involvement with malignancy, ischemic microvascular retinopathy, central retinal vein occlusion, retinal hemorrhage, retinal detachment and ocular toxicities associated with medications. Read More

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http://dx.doi.org/10.1016/j.bbmt.2018.11.033DOI Listing
December 2018
37 Reads

Amniotic membrane transplantation with or without autologous cultivated limbal stem cell transplantation for the management of partial limbal stem cell deficiency.

Clin Ophthalmol 2018 17;12:2103-2106. Epub 2018 Oct 17.

Cornea, Cataract and External Disease Services, Refractive Surgery Service, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA,

Purpose: To compare the outcomes of amniotic membrane transplantation (AMT) vs cultivated limbal stem cell transplantation (LSCT) in eyes with partial limbal stem cell deficiency (LSCD) following chemical burns.

Methods: Eyes with unilateral partial LSCD (#180° involvement) were randomized in two groups to undergo either pannus resection combined with AMT or pannus resection combined with LSCT in a tertiary eye care hospital. Primary outcome measures were time to corneal epithelialization and absence of conjunctivalization of the cornea. Read More

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https://www.dovepress.com/amniotic-membrane-transplantation-
Publisher Site
http://dx.doi.org/10.2147/OPTH.S181035DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200088PMC
October 2018
17 Reads

Herpes Simplex Virus 1 ICP22 Suppresses CD80 Expression by Murine Dendritic Cells.

J Virol 2019 Feb 17;93(3). Epub 2019 Jan 17.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns and Allen Research Institute, Los Angeles, California, USA

Herpes simplex virus type 1 (HSV-1) has the ability to delay its clearance from the eye during ocular infection. Here, we show that ocular infection of mice with HSV-1 suppressed expression of the costimulatory molecule CD80 but not CD86 in the cornea. The presence of neutralizing anti-HSV-1 antibodies did not alleviate this suppression. Read More

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http://jvi.asm.org/lookup/doi/10.1128/JVI.01803-18
Publisher Site
http://dx.doi.org/10.1128/JVI.01803-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6340034PMC
February 2019
18 Reads

Prospective analysis of pediatric ocular chemical burns: laundry detergent pods.

J AAPOS 2018 Dec 17;22(6):426-428. Epub 2018 Oct 17.

Department of Ophthalmology & Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, Tennessee; Vanderbilt University School of Medicine, Nashville, Tennessee.

Purpose: To present data on chemical ocular burns in children seen at a single tertiary care facility resulting from accidental eye exposure to the contents of laundry detergent pods.

Methods: All emergent pediatric ophthalmology consultations specific for chemical ocular burns at a level I trauma center were included as part of a prospective quality improvement investigation over a 13-month period. Age, causative agent, and examination findings at presentation and final follow-up were recorded and analyzed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10918531183054
Publisher Site
http://dx.doi.org/10.1016/j.jaapos.2018.07.349DOI Listing
December 2018
9 Reads

Skin cancer and welding.

Clin Exp Dermatol 2019 Mar 2;44(2):130-134. Epub 2018 Oct 2.

School of Medicine, West Virginia University, Morgantown, WV, USA.

Many workers in several different occupations can be exposed to ultraviolet radiation (UVR), which may increase their risk of developing skin cancer. Welding, an occupation employing an estimated 11 million people worldwide, is one such occupation. Welders are known to be exposed to the full spectrum of UVR from the welding arc and often experience burns and localized cutaneous erythema. Read More

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http://dx.doi.org/10.1111/ced.13783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6415292PMC

[Emergency management of chemical eye burns].

Lakartidningen 2018 10 2;115. Epub 2018 Oct 2.

S:t Eriks Ögonsjukhus - sektionen för gråstarr/hornhinna Stockholm, Sweden S:t Eriks Ögonsjukhus - Sektionen för gråstarr/hornhinna Stockholm, Sweden.

Chemical burn injury of the eye is a medical emergency that requires immediate intervention and structured ophthalmic assessment without unnecessary delay. Chemicals, alkali in particular but also acids, cause profound damage to the anatomy of the ocular surface or even deeper eye structures. The injury is potentially sight-threatening and can, in the worst cases, lead to loss of the eye. Read More

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October 2018
24 Reads

Anti-Inflammatory and Anti-Fibrotic Effects of Human Amniotic Membrane Mesenchymal Stem Cells and Their Potential in Corneal Repair.

Stem Cells Transl Med 2018 Dec 10;7(12):906-917. Epub 2018 Sep 10.

Research Unit, Cell and Tissue Biology, Institute of Ophthalmology Conde de Valenciana, Mexico City, Mexico.

Acute ocular chemical burns are ophthalmic emergencies requiring immediate diagnosis and treatment as they may lead to permanent impairment of vision. The clinical manifestations of such burns are produced by exacerbated innate immune response via the infiltration of inflammatory cells and activation of stromal fibroblasts. New therapies are emerging that are dedicated to repair mechanisms that improve the ocular surface after damage; for example, transplantation of stem cells (SC) has been successfully reported for this purpose. Read More

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http://doi.wiley.com/10.1002/sctm.18-0042
Publisher Site
http://dx.doi.org/10.1002/sctm.18-0042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265633PMC
December 2018
7 Reads

Ocular chemical burns from accidental exposure to topical dermatological medicinal agent.

Indian J Ophthalmol 2018 Oct;66(10):1476-1477

Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

We report a case of accidental ocular chemical injury by self-medication with a single application of a topical ayurvedic medication containing salicylic acid, phenol, and tincture iodine, which is being used in developing countries for treatment of various dermatological conditions. Read More

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http://www.ijo.in/text.asp?2018/66/10/1476/242010
Publisher Site
http://dx.doi.org/10.4103/ijo.IJO_365_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173047PMC
October 2018
4 Reads
0.930 Impact Factor

Tractional Descemet's membrane detachment after ocular alkali burns: case reports and review of literature.

BMC Ophthalmol 2018 Sep 24;18(1):256. Epub 2018 Sep 24.

Joint Shantou International Eye Center, Shantou University & the Chinese University of Hong Kong, Shantou, China.

Background: Descemet's membrane detachment (DMD) is a rare complication after ocular chemical injury and its pathogenesis remains unclear. In this study, we reported two cases of DMD with traction demonstrated on Anterior segment optical coherence tomography (AS-OCT).

Case Presentation: Two patients sustained ocular chemical injury with 50% sodium hydroxide. Read More

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http://dx.doi.org/10.1186/s12886-018-0924-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154944PMC
September 2018
3 Reads

CLEARED (Chemicals and Litmus testing with Effective Alkaline Range for Eye Damage): A Prospective, Interventional Study.

Acad Emerg Med 2018 Sep 24. Epub 2018 Sep 24.

Department of Ophthalmology & Visual Sciences, Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN.

Objectives: While immediate diagnosis and irrigation is standard chemical eye burn practice, it is unknown to what extent specific pH measurements influence management, given the frequent clinical availability of narrow-spectrum nitrazine pH strips. We hypothesize that exclusive broad-spectrum pH strip implementation leads to more accurate measurement and expedited ophthalmologic consultation.

Methods: At a Level I trauma center over 25 months, all emergent adult ophthalmology consultations for chemical burns were included in a pre-intervention (n = 22) and post-intervention (n = 20) study design. Read More

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http://dx.doi.org/10.1111/acem.13622DOI Listing
September 2018
2 Reads

Nidogen-2: Location and expression during corneal wound healing.

Exp Eye Res 2019 01 19;178:1-9. Epub 2018 Sep 19.

Departamento de Biología Celular, Histología y Farmacología, Facultad de Medicina, Grupo de Investigación Reconocido, Técnicas Ópticas para El Diagnóstico, Universidad de Valladolid, Valladolid, Spain.

Nidogen-2 is a basement membrane (BM) glycoprotein that could be a key to understanding why defects in BM regeneration occur after severe trauma to the cornea. We monitored the location and expression of nidogen-2 during corneal repair after alkali burn in rabbits. In rabbits that received both general and ocular topical anaesthesia, the central cornea of the left eye was burned by placing an 8-mm diameter filter paper soaked in 0. Read More

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http://dx.doi.org/10.1016/j.exer.2018.09.004DOI Listing
January 2019

Acute Chemical Eye Injury and Limbal Stem Cell Deficiency-A Prospective Study in the United Kingdom.

Cornea 2019 Jan;38(1):8-12

Department of Ophthalmology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.

Purpose: To analyze the incidence, nature, outcomes, and complications of acute chemical eye injuries, including the incidence of limbal stem cell deficiency (LSCD) and to compare the 2 main classifications for ocular chemical injuries: Roper-Hall (RH) and Dua.

Methods: This is a prospective, consecutive, interventional single-center study between April and October 2009 of all new patients with acute chemical eye injury presenting to the Royal Victoria Infirmary eye emergency department (EED).

Results: Of 11,683 patients who attended the EED, 98 patients (110 eyes) presented with acute chemical eye injury (60% male). Read More

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http://Insights.ovid.com/crossref?an=00003226-900000000-9676
Publisher Site
http://dx.doi.org/10.1097/ICO.0000000000001739DOI Listing
January 2019
9 Reads

Nanostructured lipid carriers containing rapamycin for prevention of corneal fibroblasts proliferation and haze propagation after burn injuries: In vitro and in vivo.

J Cell Physiol 2019 Apr 7;234(4):4702-4712. Epub 2018 Sep 7.

Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Chemical burns are a major cause of corneal haze and blindness. Corticosteroids are commonly used after corneal burns to attenuate the severity of the inflammation-related fibrosis. While research efforts have been aimed toward application of novel therapeutics. Read More

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http://dx.doi.org/10.1002/jcp.27243DOI Listing
April 2019
3 Reads
3.840 Impact Factor

High intensity focused ultrasound cyclocoagulation in dogs with primary glaucoma: a preliminary study.

Open Vet J 2018 13;8(3):305-312. Epub 2018 Aug 13.

Centre Hospitalier Vétérinaire, 275 Route Impériale, 74370 Saint-Martin Bellevue, France.

The objective was to assess the effect of high intensity focused ultrasound (HIFU) on intraocular pressure (IOP) in dogs with primary glaucoma (PG). Seven dogs (13 eyes) presenting with PG as diagnosed by a raised IOP (> 20 mm Hg) associated with consistent gonioscopy and ultrasound biomicroscopy of the ciliary cleft, with no other ocular disease. Patients were divided into 3 groups, corresponding to their pre-operative IOP (group 1 ranging from 21 to 30 mm Hg, group 2 from 31 to 40 and group 3 for 40 and above). Read More

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https://www.ajol.info/index.php/ovj/article/view/176405
Publisher Site
http://dx.doi.org/10.4314/ovj.v8i3.9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102420PMC
August 2018
17 Reads

Processed amniotic membrane for conjunctival reconstruction in complex strabismus surgery.

Strabismus 2018 Aug 21:1-7. Epub 2018 Aug 21.

a Section for Strabismus, Neuroophthalmology and Oculoplastics , Georg-August-Universitat Gottingen Universitatsmedizin , Gottingen , Germany.

Introduction: In ophthalmology amniotic membrane is usually used for the treatment of corneal ulcerations and chemical burns of the ocular surface. Also, it is useful in the treatment of conjunctival defects. There are few publications on the long-term outcomes with the use of amniotic membrane to replace the conjunctiva. Read More

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https://www.tandfonline.com/doi/full/10.1080/09273972.2018.1
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http://dx.doi.org/10.1080/09273972.2018.1502794DOI Listing
August 2018
19 Reads

Where You Cut Matters: A Dissection and Analysis Guide for the Spatial Orientation of the Mouse Retina from Ocular Landmarks.

J Vis Exp 2018 08 4(138). Epub 2018 Aug 4.

Department of Biology, The University of Akron;

Accurately and reliably identifying spatial orientation of the isolated mouse retina is important for many studies in visual neuroscience, including the analysis of density and size gradients of retinal cell types, the direction tuning of direction-selective ganglion cells, and the examination of topographic degeneration patterns in some retinal diseases. However, there are many different ocular dissection methods reported in the literature that are used to identify and label retinal orientation in the mouse retina. While the method of orientation used in such studies is often overlooked, not reporting how retinal orientation is determined can cause discrepancies in the literature and confusion when attempting to compare data between studies. Read More

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http://dx.doi.org/10.3791/57861DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6126625PMC
August 2018
13 Reads

Differential expression of corneal and limbal cytokines and chemokines throughout the clinical course of sulfur mustard induced ocular injury in the rabbit model.

Exp Eye Res 2018 12 13;177:145-152. Epub 2018 Aug 13.

Department of Pharmacology, Israel Institute for Biological Research, Ness Ziona, 74100, Israel.

Purpose: The sight threatening sulfur mustard (SM) induced ocular injury presents specific symptoms for each clinical stage. The acute injury develops in all of the exposed eyes and is characterized by erosions and severe inflammation. The irreversible late pathology develops only in part of the eyes, and is clinically expressed by chronic inflammation and corneal neovascularization (NV). Read More

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http://dx.doi.org/10.1016/j.exer.2018.08.008DOI Listing
December 2018
3 Reads

Corneal epithelial stem cells for corneal injury.

Expert Opin Biol Ther 2018 09 9;18(9):997-1003. Epub 2018 Aug 9.

c Reproductive Medicine, Developmental Biology & Reproduction , University Hospital & School of Medicine, Picardie University Jules Verne , Amiens , France.

Introduction: Ocular surface diseases with limbal insufficiency represent a therapeutic challenge for restoring vision. This corneal deficiency includes both classical ocular diseases (as chemical burns) and rare ocular diseases (as congenital aniridia and ocular cicatricial pemphigoid). Areas covered: Our understanding of limbal epithelial stem cells (LESCs) has increased the potential for treatment options. Read More

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https://www.tandfonline.com/doi/full/10.1080/14712598.2018.1
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http://dx.doi.org/10.1080/14712598.2018.1508443DOI Listing
September 2018
10 Reads

Outcomes of choroidal melanomas treated with eye physics plaques: A 25-year review.

Brachytherapy 2018 Nov - Dec;17(6):981-989. Epub 2018 Aug 3.

USC Roski Eye Institute, Keck School of Medicine of University of Southern California, Los Angeles, CA; The Vision Center at Children's Hospital Los Angeles, Los Angeles, CA. Electronic address:

Purpose: To review long-term outcomes of the University of Southern California Plaque Simulator (PS) software and Eye Physics (EP) plaques. We hypothesize that the PS/EP system delivers lower doses to critical ocular structures, resulting in lower rates of radiation toxicity and favorable visual outcomes compared to Collaborative Ocular Melanoma Study plaques, while maintaining adequate local tumor control.

Methods And Materials: Retrospective review of 133 patients treated for choroidal melanoma with I brachytherapy, using PS software and EP plaques, from 1990 through 2015. Read More

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http://dx.doi.org/10.1016/j.brachy.2018.07.002DOI Listing
August 2018
14 Reads

Amniotic Membrane Adjuncts and Clinical Applications in Wound Healing: A Review of the Literature.

Wounds 2018 Jun;30(6):168-173

Rutgers New Jersey Medical School, Newark, NJ.

Introduction: Recent advances in the preservation and processing of amnion/chorion tissue have dramatically increased the bioavailability of these wound healing factors as well as the shelf life of their related tissue products, allowing for a surge in clinical use. Many studies, including basic science, clinical trials, and randomized controlled trials, have emerged examining the biologic properties of amnion/chorion membrane products and their efficacy in wound healing.

Objective: A literature review was conducted regarding the safety and efficacy of amniotic membrane adjuncts. Read More

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June 2018
10 Reads

Olopatadine enhances recovery of alkali-induced corneal injury in rats.

Life Sci 2018 Aug 3;207:499-507. Epub 2018 Jul 3.

Pharmacology Department, Faculty of Medicine, Tanta University, El-Gish Street, Postal No. 31527 Tanta, Egypt.

Aims: The alkali-induced corneal injury is an ocular emergency that required an immediate and effective management to preserve the normal corneal functions and transparency. Olopatadine is a fast, topically-effective anti-allergic drug, which exhibited potent anti-inflammatory and anti-angiogenic abilities in different allergic animals' models. Therefore, this study aimed to evaluate the therapeutic effect of olopatadine on alkali-induced corneal injury in rats. Read More

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http://dx.doi.org/10.1016/j.lfs.2018.07.002DOI Listing
August 2018
2 Reads

Emerging Therapeutic Strategies for Limbal Stem Cell Deficiency.

J Ophthalmol 2018 27;2018:7894647. Epub 2018 Jun 27.

Department of Dermatology, Northwestern University, Chicago, IL 60611, USA.

Identification and characterization of the limbal epithelial stem cells (LESCs) has proven to be a major accomplishment in anterior ocular surface biology. These cells have been shown to be a subpopulation of limbal epithelial basal cells, which serve as the progenitor population of the corneal epithelium. LESCs have been demonstrated to play an important role in maintaining corneal epithelium homeostasis. Read More

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https://www.hindawi.com/journals/joph/2018/7894647/
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http://dx.doi.org/10.1155/2018/7894647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6040301PMC
June 2018
19 Reads

Isolation of acid from eye drop bottles being used by patients presenting with presumed scleritis.

Indian J Ophthalmol 2018 08;66(8):1084-1087

R.S. Mehta Jain Department of Biochemistry and Cell Biology, KBIRVO Block, Vision Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India.

Purpose: The aim of the study was to report the occurrence of contamination/replacement of ophthalmic eye drops with liquids of acidic nature in patients treated for nonresponding scleritis.

Methods: This was a retrospective interventional case series study.

Results: Of the three patients (4 eyes) referred as necrotizing scleritis, two were found to have acid as the content in the bottle/s being used as eye drops, confirmed using biochemical tests. Read More

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http://www.ijo.in/text.asp?2018/66/8/1084/237353
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http://dx.doi.org/10.4103/ijo.IJO_82_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6080446PMC
August 2018
3 Reads

TLR4-MyD88 pathway promotes the imbalanced activation of NLRP3/NLRP6 via caspase-8 stimulation after alkali burn injury.

Exp Eye Res 2018 11 2;176:59-68. Epub 2018 Jul 2.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China. Electronic address:

Alkali burn (AB) is one of the most serious ocular traumas in the world, characterized by extreme ocular surface disorders, critical secondary dry eye and irreversible vision loss. The exact mechanisms involved are unknown. Innate immunity, including the involvement of Toll-like receptors (TLRs) and NOD-like receptors (NLRs), is believed to participate in the pathogenesis of the epithelia, but the exact mechanisms by which TLRs transduce signals to NLRs and downstream molecules to initiate innate immunity remain poorly defined. Read More

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http://dx.doi.org/10.1016/j.exer.2018.07.001DOI Listing
November 2018
2 Reads

Care in patients with epidermal necrolysis in burn units. A nursing perspective.

Burns 2018 12 11;44(8):1962-1972. Epub 2018 Jul 11.

Clinical Pharmacology Unit, Príncipe de Asturias University Hospital, Department of Biomedical Sciences, University of Alcalá, IRYCIS, Alcalá de Henares, Madrid, Spain.

Objective: To describe how nursing care is delivered to patients with epidermal necrolysis in burn units/specialized units in Spain and a selection of countries.

Method: Descriptive cross-sectional study. Data were collected through a structured questionnaire which was sent to nurse managers in all burn units in Spain and a selection of countries. Read More

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http://dx.doi.org/10.1016/j.burns.2018.06.010DOI Listing
December 2018
10 Reads

Photokeratitis among restaurant workers: A case series.

Am J Ind Med 2018 Jul 11. Epub 2018 Jul 11.

North Carolina Division of Public Health, Charlotte, North Carolina.

This case report highlights the challenges associated with the diagnosis and workplace evaluation of occupationally acquired ultraviolet (UV) radiation-induced photokeratitis and associated skin burns in a group of restaurant workers. UV-C spectrum bulbs were inadvertently shipped and installed in insect light traps. Ocular and dermal symptoms were reported in 18 of 85 restaurant employees to varying degrees of severity over a 2-day period. Read More

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http://dx.doi.org/10.1002/ajim.22875DOI Listing
July 2018
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Neurotrophic keratitis: current challenges and future prospects.

Eye Brain 2018 28;10:37-45. Epub 2018 Jun 28.

Ophthalmology Unit, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Alma Mater Studiorum University of Bologna, Sant'Orsola-Malpighi Teaching Hospital, Bologna, Italy,

Neurotrophic keratitis (NK) is a degenerative corneal disease caused by damage of trigeminal corneal innervation, which leads to spontaneous epithelial breakdown and corneal ulceration. The impairment of corneal sensory innervation causes the reduction of both protective reflexes and trophic neuromodulators that are essential for the vitality, metabolism, and wound healing of ocular surface tissues. A wide range of ocular and systemic conditions, including herpetic keratitis, ocular chemical burns, corneal surgery, diabetes, multiple sclerosis, and neurosurgical procedures, can cause NK by damaging trigeminal innervation. Read More

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http://dx.doi.org/10.2147/EB.S117261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029608PMC
June 2018
1 Read

Utilisation d’une solution polyamphotère lors de lésions et brûlures chimiques oculaires cutanées et buccales. effet sur la douleur de la diphotérine®.

Ann Burns Fire Disasters 2017 Dec;30(4):286-291

Colorado School of Public Health, Denver, Colorado, USA.

Polyamphoteric washing solutions (PWS) have been used for several years, mainly in industries, for cases of chemical ocular or cutaneous splashes by acid or alkali. We collected 37 cases reporting the use of PWS for ocular and cutaneous chemical splashes from several centres. Among the 37 cases, 55. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6033482PMC
December 2017
2 Reads