1,759 results match your criteria Burns Ocular


Clinical Characteristics and Severity Distribution of Tertiary Eye Center Attendance by Ocular Chemical Injury Patients.

Eye Contact Lens 2022 May 17. Epub 2022 May 17.

Department of Ophthalmology, Ege University Hospital, Izmir, Turkey.

Objectives: To report demographic characteristics, types and grades of injury, regional distribution of injury severity, clinical findings, and long-term results of acute ocular chemical burns.

Methods: Medical records of patients with chemical burns between 2010 and 2020 who were admitted to Ege University less than 72 hr after the injury were reviewed. Age, gender, cause of the burn, injury severity, initial and final best-corrected visual acuity, surgical intervention, and complications were recorded. Read More

View Article and Full-Text PDF

Hypoxia-induced mesenchymal stem cells inhibit corneal fibroblast proliferation by regulating the WWP2/Notch1 axis.

Regen Med 2022 Jun 12;17(6):375-388. Epub 2022 May 12.

Department of Ophthalmology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou, Zhejiang, 325000, China.

This study aimed to explore the role of hypoxic mesenchymal stem cells (MSCs) in corneal alkali burns and the underlying mechanism. Rat corneal fibroblasts were incubated with IL-6, followed by treatment with hypoxic MSC supernatant. A rat corneal alkali burn model was implemented and processed with hypoxic MSCs. Read More

View Article and Full-Text PDF

AIP1 suppresses neovascularization by inhibiting the NOX4-induced NLRP3/NLRP6 imbalance in a murine corneal alkali burn model.

Cell Commun Signal 2022 May 6;20(1):59. Epub 2022 May 6.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China.

Background: Apoptosis signal-regulating kinase 1-interacting protein 1 (AIP1) participates in inflammatory neovascularization induction. NADPH oxidase 4 (NOX4) produces reactive oxygen species (ROS), leading to an imbalance in nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) and NLR family pyrin domain containing 6 (NLRP6) expression. The mechanisms of AIP1, NOX4, ROS and inflammasomes in corneal neovascularization were studied herein. Read More

View Article and Full-Text PDF

Ex Vivo and In Vivo Animal Models for Mechanical and Chemical Injuries of Corneal Epithelium.

J Vis Exp 2022 04 6(182). Epub 2022 Apr 6.

Department of Ophthalmology, Chang-Gung Memorial Hospital; Chang-Gung University College of Medicine;

Corneal injury to the ocular surface, including chemical burn and trauma, may cause severe scarring, symblepharon, corneal limbal stem cells deficiency, and result in a large, persistent corneal epithelial defect. Epithelial defect with the following corneal opacity and peripheral neovascularization result in irreversible visual impairment and hinder future management, especially keratoplasty. Since the animal model can be used as an effective drug development platform, models of corneal injury to the mouse and alkali burn to rabbit corneal epithelium are developed here. Read More

View Article and Full-Text PDF

Longitudinal assessment of the effect of alkali burns on corneal biomechanical properties using optical coherence elastography.

J Biophotonics 2022 Apr 23:e202200022. Epub 2022 Apr 23.

Department of Biomedical Engineering, University of Houston, Houston, TX, USA.

Eye injury due to alkali burn is a severe ocular trauma that can profoundly affect corneal structure and function, including its biomechanical properties. Here, we assess the changes in the mechanical behavior of mouse corneas in response to alkali-induced injury by conducting longitudinal measurements using optical coherence elastography (OCE). A non-contact air-coupled ultrasound transducer was used to induce elastic waves in control and alkali-injured mouse corneas in vivo, which were imaged with phase-sensitive optical coherence tomography. Read More

View Article and Full-Text PDF

Investigating the Anti-Inflammatory Effects of RCI001 for Treating Ocular Surface Diseases: Insight Into the Mechanism of Action.

Front Immunol 2022 24;13:850287. Epub 2022 Mar 24.

RudaCure Co. Ltd., Incheon, South Korea.

The ocular surface is continuously exposed to various environmental factors, and innate and adaptive immunity play crucial roles in ocular surface diseases (OSDs). Previously, we have reported that the topical application of RCI001 affords excellent anti-inflammatory and antioxidant effects in dry eye disease and ocular chemical burn models. In this study, we examined the inhibitory effects of RCI001 on the Rac1 and NLRP3 inflammasomes and . Read More

View Article and Full-Text PDF

Adolescent Vaping-Associated Trauma in the Western United States.

J Surg Res 2022 Aug 5;276:251-255. Epub 2022 Apr 5.

Division of Pediatric Surgery, University of Utah, Primary Children's Hospital, Salt Lake City, Utah.

Introduction: Electronic cigarettes (e-cigarettes) are handheld, battery-powered vaporizing devices. It is estimated that more than 25% of youth have used these devices recreationally. While vaping-associated lung injury is an increasingly recognized risk, little is known about the risk of traumatic injuries associated with e-cigarette malfunction. Read More

View Article and Full-Text PDF

Role of Anterior Segment-Optical Coherence Tomography Angiography in Acute Ocular Burns.

Diagnostics (Basel) 2022 Feb 28;12(3). Epub 2022 Feb 28.

The Cornea Institute, Kallam Anji Reddy Campus, LV Prasad Eye Institute, Hyderabad 500034, India.

Acute ocular burns have varied manifestations which require prompt diagnosis and management to prevent chronic sequelae. Of these, the detection of limbal ischemia poses a challenge because of the subjective nature of its clinical signs. Anterior segment optical coherence tomography angiography (AS-OCTA) offers an objective method of assessing ischemia in these eyes. Read More

View Article and Full-Text PDF
February 2022

Ten Years of Pediatric Ocular Chemical Burn Experience in a Tertiary Eye Care Center in Turkey.

Eye Contact Lens 2022 Apr;48(4):175-179

Department of Ophthalmology, Ege University Medical Faculty Hospital, Izmir, Turkey.

Objectives: To report 10 years of pediatric ocular chemical burn experience in a tertiary eye care center in Turkey.

Methods: Thirty-three patients aged 18 years and younger who presented with ocular chemical burn between 2011 and 2021 were enrolled. Demographic data and clinical characteristics of patients were reviewed. Read More

View Article and Full-Text PDF

Morphological changes to Schlemm's canal and the distal aqueous outflow pathway in monkey eyes with laser-induced ocular hypertension.

Exp Eye Res 2022 Jun 10;219:109030. Epub 2022 Mar 10.

Department of Ophthalmology, Boston University School of Medicine, Boston, MA, USA; Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA. Electronic address:

Though roughly 30-50% of aqueous outflow resistance resides distal to Schlemm's canal (SC), the morphology of the conventional outflow pathway distal to SC has not been thoroughly evaluated. This study examined the morphological changes along proximal and distal aspects of the conventional aqueous outflow pathway and their association with decreased outflow facility in an experimental model of glaucoma in cynomolgus macaques. Nd:YAG laser burns were made to 270-340 degrees of the trabecular meshwork (TM) of one eye (n = 6) or both eyes (n = 2) of each monkey to induce ocular hypertension. Read More

View Article and Full-Text PDF

Paediatric post-concussive symptoms: symptom clusters and clinical phenotypes.

Br J Sports Med 2022 Mar 10. Epub 2022 Mar 10.

Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.

Objective: To assess the co-occurrence and clustering of post-concussive symptoms in children, and to identify distinct patient phenotypes based on symptom type and severity.

Methods: We performed a secondary analysis of the prospective, multicentre Predicting and Preventing Post-concussive Problems in Pediatrics (5P) cohort study, evaluating children 5-17 years of age presenting within 48 hours of an acute concussion. Our primary outcome was the simultaneous occurrence of two or more persistent post-concussive symptoms on the Post-Concussion Symptom Inventory at 28 days post-injury. Read More

View Article and Full-Text PDF

Small Noncoding RNA (sncRNA1) within the Latency-Associated Transcript Modulates Herpes Simplex Virus 1 Virulence and the Host Immune Response during Acute but Not Latent Infection.

J Virol 2022 04 7;96(7):e0005422. Epub 2022 Mar 7.

Center for Neurobiology and Vaccine Development, Ophthalmology Research, Department of Surgery, Cedars-Sinai Burns & Allen Research Institute, CSMC-SSB3, Los Angeles, California, USA.

The HSV-1 latency-associated transcript (LAT) locus contains two small noncoding RNA (sncRNA) sequences (sncRNA1 and sncRNA2) that are not microRNAs (miRNAs). We recently reported that sncRNA1 is more important for activation of the herpesvirus entry mediator than sncRNA2, but its function is not known. To determine the role, if any, of sncRNA1 during herpes simplex virus 1 (HSV-1) infection , we deleted the 62-bp sncRNA1 sequence in HSV-1 strain McKrae using dLAT2903 (LAT-minus) virus, creating ΔsncRNA1 recombinant virus. Read More

View Article and Full-Text PDF

LASER-INDUCED OCULAR LESIONS WITH THULIUM FIBER LASER IN ENDOUROLOGY : AN EX VIVO STUDY.

J Endourol 2022 Mar 4. Epub 2022 Mar 4.

Tenon Hospital, Assitance Publique-Hopitaux De Paris. Pierre Et Marie Curie University, Paris 6, Urology, 4 rue de la Chine, Paris, France, 75020;

Introduction And Objectives: The Thulium Fiber Laser(Tm-F) is currently studied as an alternative to the Holmium:YAG laser(Ho:YAG), the gold-standard for endocorporeal laser lithotripsy. We aimed to evaluate the ex vivo effects of an accidental Tm-F laser exposure on bovine eyes and to test the protective action of different eyeglasses in preventing eye lesions in case of accident.

Methods: A 50W-TFL-generator(IPG Photonics®, Russia) with a wavelength of 1940nm and 200µm-core-diameter-fibers(CDF) were used. Read More

View Article and Full-Text PDF

Use of Autologous Serum Eye Drops with Contact Lenses in the Treatment of Chemical Burn-Induced Bilateral Corneal Persistent Epithelial Defects.

Biomed Res Int 2022 21;2022:6600788. Epub 2022 Feb 21.

Department of Ophthalmology, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.

Objective: We aim to evaluate the clinical effect of combined topical 20% autologous serum eye drops (ASEs) along with silicone-hydrogel soft contact lenses (SCLs) in the treatment of chemical burn-induced bilateral corneal persistent epithelial defects (PEDs) and to review the literature of related studies.

Methods: From January 1, 2017, to December 31, 2019, we conducted a retrospective chart review of 8 patients with chemical burn-induced bilateral corneal PEDs who were unsuccessfully treated with conventional medical therapy and were then treated with combined topical 20% (v/v) ASEs and silicone-hydrogel CLs. The clinical effects and effectiveness of the combined treatment were evaluated. Read More

View Article and Full-Text PDF

A new injury severity scale for ocular complications following cosmetic filler injection.

Front Biosci (Landmark Ed) 2022 02;27(2):59

Eye Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, 102218 Beijing, China.

Background: Cosmetic filler injection can cause a variety of eye complications; however, there is currently no good way to evaluate injury severity and prognosis. By analyzing the injury manifestations of severe ocular complications following cosmetic filler injection and their prognosis, we propose a new injury severity scale.

Methods: Twenty-two eyes of 22 patients experiencing ocular complications following cosmetic filler injection were followed for 6 months to observe injury characteristics, manifestations and prognosis. Read More

View Article and Full-Text PDF
February 2022

Topical Pirfenidone-Loaded Liposomes Ophthalmic Formulation Reduces Haze Development after Corneal Alkali Burn in Mice.

Pharmaceutics 2022 Jan 28;14(2). Epub 2022 Jan 28.

Instituto de Biologia Molecular en Medicina y Terapia Genica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico.

Corneal chemical burns (CCBs) frequently result in corneal fibrosis or haze, an opacity of the cornea that obstructs vision and induces corneal blindness. Diverse strategies have been employed to prevent or reduce CCB-related corneal haze. In this study, we evaluated the physicochemical characteristics and biologic effects of a topical pirfenidone (PFD)-loaded liposomal formulation (PL) on a corneal alkali burn mice model. Read More

View Article and Full-Text PDF
January 2022

Clinical toxicology of exposures to chemicals from clandestine drug laboratories: a literature review.

Clin Toxicol (Phila) 2022 May 22;60(5):559-570. Epub 2022 Feb 22.

Dutch Poisons Information Center (DPIC), University Medical Center Utrecht, Utrecht, the Netherlands.

Introduction: The synthesis of clandestine drugs is a widespread worldwide phenomenon, with clandestine drug laboratories occurring both in rural and urban areas. There is considerable unfamiliarity among medical professionals about the health risks that are associated with chemicals used in clandestine drug laboratories.

Objective: To evaluate the adverse health effects resulting from exposure to chemicals involved in the production of clandestine drugs. Read More

View Article and Full-Text PDF

Medico-legal assessment of acid attack (Vitriolage) injuries in Egypt: Fate, outcomes and permanent infirmity.

Leg Med (Tokyo) 2022 May 16;56:102046. Epub 2022 Feb 16.

Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine-Helwan University, Egypt. Electronic address:

Background: Vitriolage is an aggressive criminal act that results in different degrees of burn injuries and serious health consequences. Vitriolage has been known as a popular method of assault in some developing countries. To our knowledge, this is the first study in Egypt to study the medicolegal aspects of vitriolage crime. Read More

View Article and Full-Text PDF

Soft tissue-related injuries sustained following volcanic eruptions: An integrative review.

Burns 2021 Sep 20. Epub 2021 Sep 20.

Department of Plastic and Reconstructive Surgery & The National Burn Center, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel; Institute for Health Research, University of Notre Dame, WA, Australia.

Background: The contribution of various volcanic phenomena to immediate soft tissue injury types has received limited attention challenging emergency management planning. This integrative review sought to investigate the immediate types of soft tissue-related injury sustained following volcanic eruptions.

Methods: A systematic search was conducted in January 2020 across EMBASE, PubMed, and Scopus databases. Read More

View Article and Full-Text PDF
September 2021

Platelet-Rich Plasma (PRP) to promote corneal healing in firework-related ocular burn and total limbal stem cell deficiency (LSCD).

Eur J Ophthalmol 2022 Feb 10:11206721221080004. Epub 2022 Feb 10.

Department of Sense Organs, 9311Sapienza University of Rome, Rome, Italy.

Purpose: To report the case of persistent corneal epithelial defect in total limbal stem cell deficiency (LSCD) after severe firework-related ocular burn treated with autologous Platelet-Rich Plasma (PRP).

Case Description: A young patient, victim of fireworks trauma, presented with a large persistent epithelial defect affecting the central cornea of his left eye and progressing to stromal melting, in the context of grade VI ocular surface burn with 12 h limbal involvement. Impression cytology to the cornea confirmed a complete LSCD. Read More

View Article and Full-Text PDF
February 2022

Waves of COVID-19 Pandemic: Effect on Ocular Surface Services at a Tertiary Eye Center in India.

Cureus 2021 Dec 26;13(12):e20719. Epub 2021 Dec 26.

Cornea and Anterior Segment Services, L V Prasad Eye Institute, Hyderabad, IND.

Objective To describe the impact of lockdown and unlock phases of the coronavirus disease 2019 (COVID-19) pandemic on the ocular surface services at a tertiary eye care center in India. Methods This cross-sectional hospital-based study included 18,127 patients presenting between March 25, 2017, and July 31, 2021. A comparative analysis of the data was performed on the patients diagnosed with ocular surface disorders (allergic eye disease, cicatrizing conjunctivitis, dry eye, limbal stem cell deficiency, and ocular surface burns) and ocular surface surgeries (amniotic membrane grafting, keratoprosthesis, mucous membrane grafting, and simple limbal epithelial transplantation) presenting during the lockdown and unlock phases and the previous three years before COVID-19. Read More

View Article and Full-Text PDF
December 2021

Epidemiology of welding-associated ocular injuries.

Am J Emerg Med 2022 Apr 20;54:15-16. Epub 2022 Jan 20.

Rutgers New Jersey Medical School Department of Ophthalmology & Visual Science, Newark, NJ, United States. Electronic address:

Purpose: Currently, there exists a lack of recent epidemiological data concerning ocular injuries due to welding related activities. Our study analyzes trends in ocular injuries related to usage of welding equipment in the U.S. Read More

View Article and Full-Text PDF

Surgical approaches to autologous limbal stem cell transplantation (LSCT) following severe corneal chemical burns.

J Fr Ophtalmol 2022 Mar 19;45(3):352-357. Epub 2022 Jan 19.

Department of Ophthalmology, Adolphe de Rothschild Foundation, Paris, France.

Chemical injury of the conjunctiva and cornea are true ocular emergencies and require immediate intervention. They can produce severe, extensive ocular damage, including limbal stem cell deficiency (LSCD), and lead to irreversible visual loss. LSCD can be treated surgically through autologous limbal stem cell transplantation (LSCT). Read More

View Article and Full-Text PDF

Corneal endothelial regeneration in human eyes using endothelium-free grafts.

BMC Ophthalmol 2022 Jan 21;22(1):32. Epub 2022 Jan 21.

Department of Ophthalmology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 Qingchun Road East, Hangzhou, 310016, Zhejiang Province, People's Republic of China.

Background: To report on corneal endothelial regeneration, graft clarity, and vision recovery when using endothelium-free grafts.

Methods: We evaluated the donor's cell viability using trypan blue staining and dual staining with calcein acetoxy methyl ester and ethidium homodimer-1. To preserve eyeball integrity, we performed therapeutic penetrating keratoplasty using cryopreserved donor tissue without endothelium on 195 consecutive patients who suffered from corneal perforation due to progressive primary corneal disease such as herpes simplex keratitis, fungal keratitis, ocular thermal burns, keratoconus, and phlyctenular keratoconjunctivitis. Read More

View Article and Full-Text PDF
January 2022

Eyelid Chemical Burns: A Multidisciplinary And Challenging Approach.

Ann Burns Fire Disasters 2021 Dec;34(4):312-318

Department of Plastic Surgery and Burn Treatment, Percy Military Hospital, Clamart, France.

During second- and third-degree eyelid sulfuric acid burns, many surgeons prefer to wait until primary wound separation occurs before grafting. However, this approach may miss the chance to recover the eyelids and can cause ectropion, resulting in delayed eyeball healing with exposure keratitis. We propose that early eyelid release and grafting makes a significant difference in long-term outcomes and improves eyeball healing. Read More

View Article and Full-Text PDF
December 2021

Decorin regulates collagen fibrillogenesis during corneal wound healing in mouse in vivo.

Exp Eye Res 2022 03 11;216:108933. Epub 2022 Jan 11.

Harry S. Truman Memorial Veterans' Hospital, Columbia, MO, USA; Departments of Veterinary Medicine & Surgery and Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA; Mason Eye Institute, School of Medicine, University of Missouri, Columbia, MO, USA. Electronic address:

A characteristic rigid spatial arrangement of collagen fibrils in the stroma is critical for corneal transparency. This unique organization of collagen fibrils in corneal stroma can be impacted by the presence and interactions of proteoglycans and extracellular matrix (ECM) proteins in a corneal microenvironment. Earlier studies revealed that decorin, a leucine-rich proteoglycan in stroma, regulates keratocyte-collagen matrix assembly and wound healing in the cornea. Read More

View Article and Full-Text PDF

[Internal ophthalmoplegia after retinal laser photocoagulation].

Authors:
I A Veliyeva

Vestn Oftalmol 2021 ;137(6):110-116

Research Institute of Eye Diseases, Moscow, Russia.

Laser photocoagulation of the retina is a highly effective technique for preventing visual loss in patients with a wide range of eye fundus diseases. The procedure involves creating thermal burns in the eye fundus accompanied by tissue coagulation, but unfortunately it can lead to possible side-effects and potential complications in the future. Some of the rare complications following retinal laser photocoagulation discussed in this article are accommodative weakness and pupil dilation with eventual transitory myopia and corneal sensitivity impairment. Read More

View Article and Full-Text PDF
December 2021

Inhibition of Neovascularization and Inflammation in a Mouse Model of Corneal Alkali Burns Using Cationic Liposomal Tacrolimus.

Front Bioeng Biotechnol 2021 7;9:791954. Epub 2021 Dec 7.

Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Eye drops account for more than 90% of commercialized ophthalmic drugs. However, eye drops have certain shortcomings, such as short precorneal retention time and weak corneal penetration. The requirement of frequent instillation of eye drops also causes poor patient compliance, which may lead to further aggravation of the disease. Read More

View Article and Full-Text PDF
December 2021

Clinical Experience in Patients with Ocular Burns Treated with Boston Type I Keratoprosthesis Implantation with or Without Prophylactic Ahmed Glaucoma Valve Implantation.

Ophthalmol Ther 2022 Feb 23;11(1):421-434. Epub 2021 Dec 23.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, 510060, China.

Introduction: To compare outcomes in eyes with ocular burns following Boston Type I keratoprosthesis (KPro) implantation with and without prophylactic pars plana tube surgery.

Methods: A retrospective review of patients with ocular burns who underwent KPro surgery at Zhongshan Ophthalmic Center was performed. Twenty-six eyes of 26 patients without a preoperative diagnosis of glaucoma before KPro surgery met the inclusion criteria. Read More

View Article and Full-Text PDF
February 2022

Review of culprit drugs associated with patients admitted to the burn unit with the diagnosis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Syndrome.

Burns 2021 Aug 18. Epub 2021 Aug 18.

Department of Ophthalmology, Loyola University Medical Center, United States. Electronic address:

Purpose: Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis Syndrome (TENS) are severe and potentially lethal adverse drug reactions characterized by acute inflammation of the skin, mucous membranes, and ocular surface that typically occurs within weeks of a culprit drug ingestion. The purpose of this study is to report a retrospective trend analysis of SJS spectrum diagnoses and associated culprit drugs in patients admitted to the Loyola University Medical Center (LUMC) Burn Unit, the major referral center in the Chicagoland region for patients with SJS disease spectrum.

Methods: The electronic medical records (EMR) of 163 patients with a diagnosis of SJS/TENS admitted to the LUMC Burn Unit from 2000 to 2019 were reviewed. Read More

View Article and Full-Text PDF