9,384 results match your criteria Burns Chemical

Histopathological Characteristics of Limbal Stem Cell Deficiency Secondary to Chronic Vernal Keratoconjunctivitis.

Cornea 2021 Jun 9. Epub 2021 Jun 9.

The Cornea Institute, L V Prasad Eye Institute, Hyderabad, India; Center for Ocular Regeneration (CORE), L V Prasad Eye Institute, Hyderabad, India; and Ophthalmic Pathology Laboratory, L V Prasad Eye Institute, Hyderabad, India.

Purpose: To describe the histopathological characteristics of limbal stem cell deficiency (LSCD) due to chronic vernal keratoconjunctivitis (VKC).

Methods: This retrospective study included 14 eyes of 13 patients who underwent simple limbal epithelial transplantation for total LSCD from 2017 to 2018. The histological characteristics of the excised fibrovascular pannus were compared between 2 groups of 7 eyes, each with LSCD due to VKC and chemical burns (CB). Read More

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J Emerg Med 2021 Jun 2. Epub 2021 Jun 2.

Department of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

Background: Burns are a common condition presenting to the emergency department; the majority are thermal burns. The treatment for thermal burns and chemical burns differs greatly, and prompt recognition of a chemical burn is necessary. An often unrecognized and underestimated type of chemical burn is an alkali burn from wet cement. Read More

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Spectroscopic characterization of neptunium(VI), plutonium(VI), americium(VI) and neptunium(V) encapsulated in uranyl nitrate hexahydrate.

Phys Chem Chem Phys 2021 Jun 4. Epub 2021 Jun 4.

Nuclear Engineering and Science Center, Texas A&M University, College Station, TX 77843, USA.

The coordination of crystalline products resulting from the co-crystallization of Np(vi), Pu(vi), Am(vi), and Np(v) with uranyl nitrate hexahydrate (UNH) has been revealed through solid-state spectroscopic characterization via diffuse reflectance UV-Vis-NIR spectroscopy, SEM-EDS, and extended X-ray absorption fine structure (EXAFS) spectroscopy. Density functional and multireference wavefunction calculations were performed to analyze the An(vi/v)O2(NO3)2·2H2O electronic structures and to help assign the observed transitions in the absorption spectra. EXAFS show a similar coordination between the U(VI) in UNH and Np(vi) and Pu(vi); while Am resulted in a similar coordination to Am(iii), as reduction of Am(vi) occurred prior to EXAFS data being obtained. Read More

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Characterizing the Role of Biologically Relevant Fluid Dynamics on Silver Nanoparticle Dependent Oxidative Stress in Adherent and Suspension In Vitro Models.

Antioxidants (Basel) 2021 May 23;10(6). Epub 2021 May 23.

Department of Chemical and Materials Engineering, University of Dayton, Dayton, OH 45469-0256, USA.

Silver nanoparticles (AgNPs) are being employed in numerous consumer goods and applications; however, they are renowned for inducing negative cellular consequences including toxicity, oxidative stress, and an inflammatory response. Nanotoxicological outcomes are dependent on numerous factors, including physicochemical, biological, and environmental influences. Currently, NP safety evaluations are carried out in both cell-based in vitro and animal in vivo models, with poor correlation between these mechanisms. Read More

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Kaempferol-3-O-Glucuronide Ameliorates Non-Alcoholic Steatohepatitis in High-Cholesterol-Diet-Induced Larval Zebrafish and HepG2 Cell Models via Regulating Oxidation Stress.

Life (Basel) 2021 May 14;11(5). Epub 2021 May 14.

School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

NAFLD (non-alcoholic fatty liver disease) is one of the most prominent liver diseases in the world. As a metabolic-related disease, the development of NAFLD is closely associated with various degrees of lipid accumulation, oxidation, inflammation, and fibrosis. Ilex chinensis Sims is a form of traditional Chinese medicine which is used to treat bronchitis, burns, pneumonia, ulceration, and chilblains. Read More

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Heterogeneous delivery across the blood-brain barrier limits the efficacy of an EGFR-targeting antibody drug conjugate in glioblastoma.

Neuro Oncol 2021 May 29. Epub 2021 May 29.

Department of Radiation Oncology, Mayo Clinic, Rochester, MN.

Background: Antibody drug conjugates (ADCs) targeting the epidermal growth factor receptor (EGFR), such as depatuxizumab mafodotin (Depatux-M), is a promising therapeutic strategy for glioblastoma (GBM) but recent clinical trials did not demonstrate a survival benefit. Understanding the mechanisms of failure for this promising strategy is critically important.

Methods: PDX models were employed to study efficacy of systemic vs intracranial delivery of Depatux-M. Read More

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Hydrogel with silver nanoparticles synthesized by Mimosa tenuiflora for second-degree burns treatment.

Sci Rep 2021 May 28;11(1):11312. Epub 2021 May 28.

Department of Physics, Nanotechnology Graduate Program, University of Sonora, Rosales and Transversal, 83000, Hermosillo, Sonora, Mexico.

In this work we use Mimosa tenuiflora (MtE) extracts as reducing agents to synthesize silver nanoparticles (AgMt NPs) which were characterized by DPPH and Total Polyphenols Assays, UV-visible, X-ray diffractometer (XRD), high-resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectroscopy (XPS) and Thermogravimetric analysis (TGA). AgMt NPs possess average sizes of 21 nm and fcc crystalline structure, it was also confirmed that the MtE is present in the AgMt NPs even after the cleaning protocol applied. Subsequently, carbopol hydrogels were made and the MtE and the synthesized AgMt NPs were dispersed in different gels (MtE-G and AgMt NPs-G, respectively) at 100 µg/g concentration. Read More

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Magnetically Assembled Photonic Crystal Gels with Wide Thermochromic Range and High Sensitivity.

Macromol Rapid Commun 2021 May 24:e2100200. Epub 2021 May 24.

School of Chemical Engineering, Sichuan University, Chengdu, Sichuan, 610065, P. R. China.

Thermochromic poly(N-isopropyl acrylamide) (PNIPAM) photonic crystal gels based on 1D magnetically assembling colloidal nanocrystal clusters have attracted much attention due to its convenient preparation process, striking color response, and good mechanical strength. However, there remain challenges to broaden the thermochromic range and improve the sensitivity for their iridescent color display. Here, a PNIPAM photonic gel with wide thermochromic range and high sensitivity is prepared by using four-arm star poly(ethylene glycol) acrylamide (PEGAAm) as cross-linker at appropriately reduced magnetic field strength as well as cross-linker content. Read More

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NETosis in the pathogenesis of acute lung injury following cutaneous chemical burns.

JCI Insight 2021 May 24;6(10). Epub 2021 May 24.

Division of Pulmonary, Allergy and Critical Care, Department of Medicine.

Despite the high morbidity and mortality among patients with extensive cutaneous burns in the intensive care unit due to the development of acute respiratory distress syndrome, effective therapeutics remain to be determined. This is primarily because the mechanisms leading to acute lung injury (ALI) in these patients remain unknown. We test the hypothesis that cutaneous chemical burns promote lung injury due to systemic activation of neutrophils, in particular, toxicity mediated by the deployment of neutrophil extracellular traps (NETs). Read More

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Metabolic syndrome screening using visceral adipose tissue (VAT) from opportunistic MRI locations in a multi-ethnic population.

Obes Res Clin Pract 2021 May-Jun;15(3):227-234. Epub 2021 May 21.

University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI, 96813, USA. Electronic address:

Objective: To determine if visceral adipose tissue (VAT) area measured through MRI can be used opportunistically to assess the presence of cardiometabolic risk factors and compare its performance to simpler adiposity measures.

Methods: A cross-sectional analysis was carried out on a subset of 1683 participants (856 women) from the Adiposity Phenotype Study (mean age=69.2y; range 59. Read More

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Comparison of ozone measurement methods in biomass burning smoke: an evaluation under field and laboratory conditions.

Atmos Meas Tech 2021 Mar;14(3):1783-1800

Center for Environmental Measurement and Modeling, Office of Research and Development, United States Environmental Protection Agency, Research Triangle Park, North Carolina, United States of America.

In recent years wildland fires in the United States have had significant impacts on local and regional air quality and negative human health outcomes. Although the primary health concerns from wildland fires come from fine particulate matter (PM), large increases in ozone (O) have been observed downwind of wildland fire plumes (DeBell et al., 2004; Bytnerowicz et al. Read More

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Hydrophobic Interactions between DNA Duplexes and Synthetic and Biological Membranes.

J Am Chem Soc 2021 Jun 20;143(22):8305-8313. Epub 2021 May 20.

Department of Chemistry, Institute of Structural and Molecular Biology, University College London, London WC1H 0AJ, United Kingdom.

Equipping DNA with hydrophobic anchors enables targeted interaction with lipid bilayers for applications in biophysics, cell biology, and synthetic biology. Understanding DNA-membrane interactions is crucial for rationally designing functional DNA. Here we study the interactions of hydrophobically tagged DNA with synthetic and cell membranes using a combination of experiments and atomistic molecular dynamics (MD) simulations. Read More

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Longitudinal Assessment of Alkali Injury on Mouse Cornea Using Anterior Segment Optical Coherence Tomography.

Transl Vis Sci Technol 2021 Mar;10(3)

Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX, USA.

Purpose: Chemical burns due to alkalis cause extensive damage to the ocular surface leading to blindness. Assessment of ocular burn could be challenging due to severe opacity, inflammation, and angiogenesis. Anterior segment optical coherence tomography (AS-OCT) and OCT angiography (OCTA) may provide fast, non-invasive deep tissue visualization of pathology with high sensitivity in conjunction with slit-lamp analysis. Read More

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Referral Patterns of Patients with Limbal Stem Cell Deficiency to a Specialized Tertiary Center in the United Kingdom.

Ophthalmol Ther 2021 May 17. Epub 2021 May 17.

Department of Ophthalmology Royal Victoria Infirmary, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.

Introduction: Limbal stem cell deficiency (LSCD) is a potentially blinding disease; hence, referral to a specialist service is becoming increasingly common. Our aim was to investigate the referral patterns and associated details.

Methods: We conducted an audit of 100 consecutive patients with LSCD who were referred to our service from 2011 to 2018. Read More

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Peripubertal serum levels of dioxins, furans and PCBs in a cohort of Russian boys: can empirical grouping methods yield meaningful exposure variables?

Chemosphere 2021 Jul 25;275:130027. Epub 2021 Feb 25.

Department of Environmental Health, Harvard T. H. Chan School of Public Health, 677 Huntington Ave, Boston, MA, 02115, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA. Electronic address:

Background: Dioxins, furans and polychlorinated biphenyls (PCBs) are endocrine disruptors with half-lives of months to years in humans. Peripubertal exposure to these chemicals may disrupt pubertal timing. Biomarker exposure metrics like the sum of non-dioxin-like PCBs in serum (∑NDL-PCBs) involve chemicals with different hypothetical effects. Read More

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Adjunct Use of Therapeutic Scleral Lens for Exposure Keratopathy after Severe Chemical Burn.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):243-247. Epub 2021 Apr 12.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.

Severe chemical burns can damage the periocular area causing exposure keratopathy and resulting in ocular pain, foreign body sensation, epiphora, photophobia, and vision loss. A custom fit large diameter therapeutic scleral lens can protect the ocular surface by preventing desiccation and providing immediate improvement in comfort. This case describes the management of a patient with extensive chemical burn with complete lid loss and exposure keratopathy who has maintained excellent visual acuity and comfort with therapeutic scleral lens use. Read More

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A pharmacological perspective of banana: implications relating to therapeutic benefits and molecular docking.

Food Funct 2021 Jun;12(11):4749-4767

Institute of Advanced Study in Science and Technology, Vigyan Path, Paschim Boragaon, Guwahati-781035, Assam, India. and Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.

Banana is one of the most nutritious fruits, as it is rich in carbohydrates, proteins, fatty acids, and minerals. Banana has been used in traditional medicines for managing coughs and colds, ulcers, burns, and diarrhea. Banana contains various bioactive compounds, such as alkaloids, phenols, flavonoids, tannins, and saponins, with reported therapeutic benefits, including antioxidant, anti-diabetic, anti-cancer, anti-inflammatory, and anti-microbial activities. Read More

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Decontamination effectiveness and the necessity of innovation in a large-scale disaster simulation.

Am J Disaster Med 2021 Winter;16(1):67-73

Associate Professor, Institute of Health Sciences Education and Department of Medicine, McGill University, Montreal, Canada.

Background: Chemical, biological, radiologic, nuclear, and explosive (CBRNE) events threaten the health and integrity of human populations across the globe. Effective decontamination is a central component of CBRNE disaster response.

Objective: This paper provides an objective determination of wet decontamination effectiveness through the use of a liquid-based contaminant proxy and describes the mobilization and adaptation of easily available materials for the needs of decontamination in pediatric victims. Read More

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Priming human adipose-derived mesenchymal stem cells for corneal surface regeneration.

J Cell Mol Med 2021 Jun 5;25(11):5124-5137. Epub 2021 May 5.

CellTec-UB, Department of Cell Biology, University of Barcelona, Barcelona, Spain.

Limbal stem cells (LSC) maintain the transparency of the corneal epithelium. Chemical burns lead the loss of LSC inducing an up-regulation of pro-inflammatory and pro-angiogenic factors, triggering corneal neovascularization and blindness. Adipose tissue-derived mesenchymal stem cells (AT-MSC) have shown promise in animal models to treat LSC deficiency (LSCD), but there are not studies showing their efficacy when primed with different media before transplantation. Read More

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Impact of e-Liquid Composition, Coil Temperature, and Puff Topography on the Aerosol Chemistry of Electronic Cigarettes.

Chem Res Toxicol 2021 May 5. Epub 2021 May 5.

Department of Environmental Toxicology, University of California at Davis, Davis, California 95616, United States.

E-cigarette aerosol is a complex mixture of gases and particles with a composition that is dependent on the e-liquid formulation, puffing regimen, and device operational parameters. This work investigated mainstream aerosols from a third generation device, as a function of coil temperature (315-510 °F, or 157-266 °C), puff duration (2-4 s), and the ratio of propylene glycol (PG) to vegetable glycerin (VG) in e-liquid (100:0-0:100). Targeted and untargeted analyses using liquid chromatography high-resolution mass spectrometry, gas chromatography, in situ chemical ionization mass spectrometry, and gravimetry were used for chemical characterizations. Read More

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Accelerated Skin Wound Healing by Electrical Stimulation.

Adv Healthc Mater 2021 May 4:e2100557. Epub 2021 May 4.

College of Chemistry and Chemical Engineering, Center of Nanoenergy Research, Guangxi University, Nanning, 530004, China.

When the integrity of the skin got damaged, an endogenous electric field will be generated in the wound and a series of physiological reactions will be initiated to close the wound. The existence of the endogenous electric field of the wound has a promoting effect on all stages of wound healing. For wounds that cannot heal on their own, the exogenous electric field can assist the treatment. Read More

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A Phase II Study on the Use of Convalescent Plasma for the Treatment of Severe COVID-19- A Propensity Score-Matched Control Analysis.

Microorganisms 2021 Apr 11;9(4). Epub 2021 Apr 11.

Department of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, 11528 Athens, Greece.

COVID-19 is a global pandemic associated with increased morbidity and mortality. Convalescent plasma (CP) infusion is a strategy of potential therapeutic benefit. We conducted a multicenter phase II study to evaluate the efficacy and safety of CP in patients with COVID-19, grade 4 or higher. Read More

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Rare Operative Intervention for Urinary and Fecal Incontinence-Associated Dermatitis.

Wounds 2021 Apr;33(4):E31-E33

Arizona Burn Center, Phoenix, Arizona.

Incontinence-associated dermatitis (IAD) is considered a cause of moisture-associated skin damage after prolonged exposure to urinary and fecal incontinence. While partial-thickness burns are often managed with topical therapies, daily dressing changes, patient positioning, hydration, nutrition, and pain management, deep partial-thickness and full-thickness burn injuries require surgical excision and, ultimately, skin grafting. The elderly and very young as well as those with medical comorbidities can develop urinary and fecal incontinence. Read More

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Burn-induced hypermetabolism and skeletal muscle dysfunction.

Am J Physiol Cell Physiol 2021 Apr 28. Epub 2021 Apr 28.

Institute of Medical Science, University of Toronto, Canada; Departments of Surgery and Immunology, University of Toronto, Canada; Sunnybrook Research Institute, Toronto, Canada; Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Toronto, Canada.

Critical illnesses, including sepsis, cancer cachexia and burn injury, invoke a milieu of systemic metabolic and inflammatory derangements that ultimately results in increased energy expenditure leading to fat and lean mass catabolism. Burn injuries present a unique clinical challenge given the magnitude and duration of the hypermetabolic response in comparison to other forms of critical illness, which drastically increase the risk of morbidity and mortality. Skeletal muscle metabolism is particularly altered as a consequence of burn-induced hypermetabolism as it primarily provides a main source of fuel in support of wound healing. Read More

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Surgical Management and Recent Advances in Chemical Injury: A 5-year Review.

Semin Ophthalmol 2021 Apr 25:1-7. Epub 2021 Apr 25.

Department of Ophthalmology, All India Institute of Medical Sciences, Patna, India.

: To review the surgical management options in ocular chemical burn, including newer advances.: Online literature search of published articles over last 5 years on surgical management of ocular chemical burn and newer advances were performed on December 30, 2020.: Following literature search and screening using adequate filters, 67 review articles on surgical management of ocular chemical burns were retrieved. Read More

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Synthetic high-density lipoprotein nanoparticles: Good things in small packages.

Ocul Surf 2021 Apr 21;21:19-26. Epub 2021 Apr 21.

Department of Dermatology Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Electronic address:

Medicine has been a great beneficiary of the nanotechnology revolution. Nanotechnology involves the synthesis of functional materials with at least one size dimension between 1 and 100 nm. Advances in the field have enabled the synthesis of bio-nanoparticles that can interface with physiological systems to modulate fundamental cellular processes. Read More

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[Epidemiological characteristics and outcome analysis of 266 patients with inhalation injuries combined with total burn area less than 30% total body surface area].

Zhonghua Shao Shang Za Zhi 2021 Apr;37(4):340-349

Burn Institute of PLA, Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, Shanghai 200433, China.

To explore the epidemiological characteristics and treatment outcomes of patients with inhalation injuries combined with total burn area less than 30% total body surface area (TBSA). A retrospective observational study was performed on medical records of 266 patients with inhalation injuries combined with total burn area less than 30%TBSA who were admitted to the First Affiliated Hospital of Naval Medical University from January 2008 to December 2016 and met the inclusion criteria. The following statistical data of the patients were collected, including gender, age, injury site, injurious factors of inhalation injury, degree of inhalation injury, combined total burn area, tracheotomy, time of tracheotomy, mechanical ventilation, whether stayed in intensive care unit (ICU) or not, microbial culture results of bronchoalveolar lavage fluid, length of hospital stay, length of ICU stay, mechanical ventilation days, and respiratory tract infections. Read More

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Clinical Utility of an Exoskeleton Robot Using 3-Dimensional Scanner Modeling in Burn Patient: A Case Report.

J Burn Care Res 2021 Apr 21. Epub 2021 Apr 21.

Department of Rehabilitation Medicine, Hangang Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.

Hands are the part of the body that are most commonly involved in burns, and the main complications are finger joint contractures and nerve injuries. Hypertrophic scarring cannot be avoided despite early management of acute hand burn injuries, and some patients may need application of an exoskeleton robot to restore hand function. To do this, it is essential to individualize the customization of the robot for each patient. Read More

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Guttate psoriasis: a case of unusual evolution of an occupation-related skin chemical burns.

Med Lav 2021 Apr 20;112(2):168-170. Epub 2021 Apr 20.

Pavia Poison Control Centre - National Toxicology Information Centre - Clinical and Experimental Lab, Toxicology Unit - Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy.

Introduction: Chemical burns are a risk in domestic and occupational accidents due to the common use of caustic agents. Long-term sequelae are normally due to the amount of skin and underlying tissues damaged. We describe a case of work-related chemical burns with unusual evolution in guttate psoriasis. Read More

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