9,709 results match your criteria Burns Chemical

Effects of a Topically Applied Oral Wound Dressing Film on Intra-oral Wound Healing in Rabbits.

In Vivo 2022 Jul-Aug;36(4):1745-1752

College of Veterinary Medicine and BK21 Four Program, Chonnam National University, Gwangju, Republic of Korea.

Background/aim: Oral lesions are a common clinical symptom that can impair the quality of life of patients. Several treatments have been developed; however, therapies for wounds on the oral mucosa are symptomatic and unsatisfactory. This study aimed to evaluate the efficacy of an oral wound dressing (OWD) film in healing excision and chemical burns using a rabbit oral wound model and to demonstrate the effect of physical barriers during wound healing. Read More

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Commercial wound dressings for the treatment of exuding wounds: an in-depth physico-chemical comparative study.

Burns Trauma 2022 21;10:tkac024. Epub 2022 Jun 21.

Smart Polymeric Biomaterials Research Group, Biomaterials and Tissue Engineering (SIEM) @ Campus Group T Leuven, Andreas Vesaliusstraat 13, 3000 Leuven, Belgium.

Background: Nowadays, a wide range of wound dressings is already commercially available. The selection of the dressing is of paramount importance as inappropriate wound management and dressing selection can delay the wound healing process. Not only can this be distressing for the patient, but it can also contribute to complications such as maceration and subsequent infection. Read More

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Core-shell alum-borneol fiber for high bioavailability.

Prog Biomater 2022 Jun 22. Epub 2022 Jun 22.

Beijing Key Laboratory of Advanced Functional Polymer Composites, College of Material Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.

Currently, the treatment of burns poses a significant challenge to clinical surgical. The use of nanofibers combined with drugs provides an entirely new option for treating burns. Alum-borneol combination has been shown as a promising alternative in clinical burn treatment. Read More

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NLRP3 inflammasome-mediated choroid plexus hypersecretion contributes to hydrocephalus after intraventricular hemorrhage via phosphorylated NKCC1 channels.

J Neuroinflammation 2022 Jun 21;19(1):163. Epub 2022 Jun 21.

Department of Neurosurgery and State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), 29 Gaotanyan Street, Shapingba District, Chongqing, 400038, China.

Background: Hydrocephalus is a severe complication of intracerebral hemorrhage with ventricular extension (ICH-IVH) and causes cerebrospinal fluid (CSF) accumulation. The choroid plexus epithelium plays an important role in CSF secretion and constitutes the blood-CSF barrier within the brain-immune system interface. Although the NLRP3 inflammasome, as a key component of the innate immune system, promotes neuroinflammation, its role in the pathogenesis of hydrocephalus after hemorrhage has not been investigated. Read More

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Evaluation of potential toxicity of smoke from controlled burns of furnished rooms - effect of flame retardancy.

J Toxicol Environ Health A 2022 Jun 14:1-15. Epub 2022 Jun 14.

Southwest Research Institute, San Antonio, TX USA.

It has been reported that incorporation of fire retardants into home furnishings and electronics increases the toxicity of smoke produced during combustion in house fires. Studies have been limited to exercises in analytical chemistry but the biological effects of emissions, particularly regarding chronic toxicity, have not been investigated. The combustion of furnishings with and without chemical flame retardants (FR) regarding (1) ignition resistance and fire progression, (2) chemical composition of smoke (analytical chemistry), and (3) toxicity was compared. Read More

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Study of the Effectiveness of Drug No. 1 on the Model of Alkaline Eye Burn in Rabbits.

J Popul Ther Clin Pharmacol 2022 1;29(1):e26-e39. Epub 2022 Mar 1.

Laboratory of Drug Toxicology of the Institute of Experimental Cardiology of Federal state budgetary institution "National medical research center of cardiology" of the Ministry of health of the Russian Federation, Moscow, Russian Federation;

Studies have shown that 0.05 mL/kg of drug No. 1 as 1:15 dilution with sterile saline solution has anti-inflammatory, wound-healing, and angioprotective effects if instilled in both eyes of rabbits twice a day for 30 days after an alkaline burn. Read More

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Chemical burn to the skin: A systematic review of first aid impacts on clinical outcomes.

Burns 2022 May 14. Epub 2022 May 14.

University of Western Australia, Burn Injury Research Unit, School of Biomedical Sciences, 35 Stirling Highway, Crawley, Western Australia, 6009, Australia; Fiona Wood Foundation, 11 Robin Warren Drive, Murdoch, Western Australia 6150, Australia. Electronic address:

Chemical burns can cause deep injury and subsequently significant scarring to the skin. The mechanism and pathophysiology of chemical burns is distinct to thermal burns, and recommended first aid approaches are consequently different. Twenty minutes of cool running water is an effective first aid measure to improve outcomes after thermal burn. Read More

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Chimeric Ligands of Pili and Lectin A Inhibit Tolerance, Persistence, and Virulence Factors of over a Wide Range of Phenotypes.

ACS Infect Dis 2022 Jun 6. Epub 2022 Jun 6.

Department of Chemistry, Syracuse University, 1-014 Center of Science and Technology, Syracuse, New York 13244-4100, United States.

Bacteria readily form resilient phenotypes to counter environmental and antibiotic stresses. Here, we demonstrate a class of small molecules that inhibit a wide range of phenotypes and enable antibiotics to kill previously tolerant bacteria, preventing the transition of tolerant bacteria into a persistent population. We identified two proteins, type IV pili and lectin LecA, as receptors for our molecules by methods including a new label-free assay based on bacterial motility sensing the chemicals in the environment, the chemical inhibition of bacteriophage adsorption on pili appendages of bacteria, and fluorescence polarization. Read More

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Management of Symblepharon Prior to Keratoprosthesis in Chronic Ocular Burns: A Sequential Approach.

Cureus 2022 Apr 29;14(4):e24611. Epub 2022 Apr 29.

Cornea and Anterior Segment, L V Prasad Eye Institute, Hyderabad, IND.

This report describes two cases with stepwise management of chronic ocular burn sequelae with concurrent total limbal stem cell deficiency (LSCD) and advanced symblepharon. Both were mono-ocular patients with the other eye being phthisical. In both cases, a sequential approach was planned, and at the first stage, the symblepharon was released to stabilize the ocular surface and form the fornices. Read More

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Chemical composition, docking simulations and burn wound healing effect of Micromeria fruticosa extract and its isolated flavonoidal compound.

Pak J Pharm Sci 2022 Mar;35(2):507-517

Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmacy, Al Azhar University, Gaza, Palestine.

The study aimed to investigate the constituents of the ethanolic extract of Micromeria fruticosa and evaluate its antimicrobial and burn healing activities and the isolated compound, rutin. The plant was extracted with ethanol and the active constituents were isolated. The antimicrobial activities of the extract and the isolated compounds were assessed. Read More

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Pycnogenol a promising remedy for diabetic keratopathy in experimentally induced corneal alkali burns in diabetic rats.

BMC Vet Res 2022 May 30;18(1):209. Epub 2022 May 30.

Department of Surgery, Anesthesiology, and Radiology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt.

Aim: This study aimed to investigate the efficiency of topically applied pycnogenol (PYC) in healing the standardized alkaline corneal ulcer in diabetic and normal rats.

Materials And Methods: The corneal alkali-burn injury (CA-I) model was unilaterally developed in Wistar rats by filter paper saturated with 0.01 M of NaOH and touching the eyes for 45 s. Read More

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Cutaneous Allergic reactions to pine processionary caterpillar (Thaumetopoea Pityocampa): a complicated cutaneous reaction in an infant and review of the literature.

Turk J Pediatr 2022 ;64(2):389-393

Division of Pediatric Allergy & Immunology, Near East University, Faculty of Medicine, Nicosia, North Cyprus.

Background: Thaumetopoea Pityocampa (TP) are frequent in the Mediterranean region especially affecting forest workers in pinewood areas. The common symptoms include swelling, rash or burns like any form of dermatitis. The reactions can be triggered by mechanical, chemical or allergic factors and the `allergic` reaction is caused by sensitization to a hair protein named `thaumetopoein`. Read More

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Lyophilized Filovirus Glycoprotein Vaccines: Peroxides in a Vaccine Formulation with Polysorbate 80-Containing Adjuvant are Associated with Reduced Neutralizing Antibody Titers in Both Mice and Non-Human Primates.

J Pharm Sci 2022 May 21. Epub 2022 May 21.

Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO 80303, United States. Electronic address:

Zaire ebolavirus, Sudan ebolavirus, and Marburg marburgvirus are the filoviruses most commonly associated with human disease. Previously, we administered a three-dose regimen of trivalent vaccines comprising glycoprotein antigens from each virus in mice and non-human primates (NHPs). The vaccines, which contained a polysorbate 80-stabilized squalane-in-water emulsion adjuvant and were lyophilized from a solution containing trehalose, produced high antibody levels against all three filovirus antigens. Read More

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Electrochemical Deconstructive Functionalization of Cycloalkanols via Alkoxy Radicals Enabled by Proton-Coupled Electron Transfer.

Org Lett 2022 Jun 23;24(21):3890-3895. Epub 2022 May 23.

Cardiff Catalysis Institute, School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, United Kingdom.

Herein, we report a new electrochemical method for alkoxy radical generation from alcohols using a proton-coupled electron transfer (PCET) approach, showcased via the deconstructive functionalization of cycloalkanols. The electrochemical method is applicable across a diverse array of substituted cycloalkanols, accessing a broad range of synthetically useful distally functionalized ketones. The orthogonal derivatization of the products has been demonstrated through chemoselective transformations, and the electrochemical process has been performed on a gram scale in continuous single-pass flow. Read More

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Bionic Prostheses: The Emerging Alternative to Vascularised Composite Allotransplantation of the Limb.

Front Surg 2022 6;9:873507. Epub 2022 May 6.

The Ex-Vivo Research Centre CIC, Alderley Park, Macclesfield, United Kingdom.

Twenty years have surpassed since the first vascularised composite allotransplantation (VCA) of the upper limb. This is an opportunity to reflect on the position of VCA as the gold standard in limb reconstruction. The paucity of recipients, tentative clinical outcomes, and insufficient scientific progress question whether VCA will remain a viable treatment option for the growing numbers of amputees. Read More

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An Updated Account On Formulations And Strategies For The Treatment Of Burn Infection - A Review.

Curr Pharm Des 2022 May 19. Epub 2022 May 19.

Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University (MRSPTU), Bathinda, 151001, Punjab, India.

Background Burn injury is considered one of the critical injuries of the skin. According to WHO (World Health Organization), approximately 3,00,000 deaths are caused each year mainly due to fire burns, with additional deaths attributed to heat and other causes of burn e.g. Read More

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Clinicopathologic and Genomic Landscape of Non-Small Cell Lung Cancer Brain Metastases.

Oncologist 2022 May 22. Epub 2022 May 22.

Foundation Medicine, Inc., Cambridge, MA, USA.

Background: In patients with non-small cell lung cancer (NSCLC), 10%-40% will eventually develop brain metastases. We present the clinicopathologic, genomic, and biomarker landscape of a large cohort of NSCLC brain metastases (NSCLC-BM) samples.

Materials And Methods: We retrospectively analyzed 3035 NSCLC-BM tested with comprehensive genomic profiling (CGP) during routine clinical care. Read More

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Clinical Characteristics and Severity Distribution of Tertiary Eye Center Attendance by Ocular Chemical Injury Patients.

Eye Contact Lens 2022 Jul 17;48(7):295-299. Epub 2022 May 17.

Department of Ophthalmology, Ege University Hospital, Izmir, Turkey.

Objectives: To report demographic characteristics, types and grades of injury, regional distribution of injury severity, clinical findings, and long-term results of acute ocular chemical burns.

Methods: Medical records of patients with chemical burns between 2010 and 2020 who were admitted to Ege University less than 72 hr after the injury were reviewed. Age, gender, cause of the burn, injury severity, initial and final best-corrected visual acuity, surgical intervention, and complications were recorded. Read More

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Occupational Health and Safety of Immigrant Hotel Housekeepers.

Workplace Health Saf 2022 May 14:21650799221090712. Epub 2022 May 14.

Texas A&M University.

Background: The accommodations sector is one of the largest employers of immigrant and minority workers in the United States. Hotel housekeepers represent the industry's largest workforce while facing difficult work conditions, health hazards, and psychological stress. This is one of the few empirical studies that address the working conditions of housekeepers in the United States and their perspective of health challenges they face. Read More

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Potassium permanganate: A 'Desert Island drug' in Dermatology.

Clin Exp Dermatol 2022 May 15. Epub 2022 May 15.

Department of Dermatology,Venereology and Leprosy, Sri Manakula Vinayagar Medical College and Hospital, Pondicherry, India.

Potassium permanganate (KMnO4) is an over the-counter available astringent with oxidising and antiseptic property used by the dermatologists since ages. It is often used as compresses and baths for various exudative dermatoses. Its advantages include lower cost, good healing rate and reduced allergenic potential. Read More

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Systematic Screening of Chemical Constituents in the Traditional Chinese Medicine by UHPLC-Q-Exactive Orbitrap Mass Spectrometry.

Molecules 2022 Apr 19;27(9). Epub 2022 Apr 19.

Sino-Pakistan Center on Traditional Chinese Medicine, School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua 418000, China.

(dried root of (Royle) Johnst.) has been used in traditional Chinese medicine (TCM) to treat macular eruptions, measles, sore throat, carbuncles, burns, skin ulcers, and inflammation. Previous studies have shown that shikonins and shikonofurans are two of their main bioactive ingredients. Read More

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The Role of Ferroptosis in Adverse Left Ventricular Remodeling Following Acute Myocardial Infarction.

Cells 2022 04 20;11(9). Epub 2022 Apr 20.

Department of Anatomy, Biochemistry & Physiology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA.

Ferroptosis is an iron-dependent form of regulated cell death and is distinct from other conventional forms of regulated cell death. It is often characterized by the dysfunction of the antioxidant selenoprotein glutathione peroxidase 4 (GPX4) antioxidant system. This loss of antioxidant capacity leads to the peroxidation of lipids and subsequent compromised plasma membrane structure. Read More

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Hypoxia-induced mesenchymal stem cells inhibit corneal fibroblast proliferation by regulating the WWP2/Notch1 axis.

Regen Med 2022 06 12;17(6):375-388. Epub 2022 May 12.

Department of Ophthalmology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Ouhai District, Wenzhou, Zhejiang, 325000, China.

This study aimed to explore the role of hypoxic mesenchymal stem cells (MSCs) in corneal alkali burns and the underlying mechanism. Rat corneal fibroblasts were incubated with IL-6, followed by treatment with hypoxic MSC supernatant. A rat corneal alkali burn model was implemented and processed with hypoxic MSCs. Read More

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Urinary phthalate metabolite concentrations during four windows spanning puberty (prepuberty through sexual maturity) and association with semen quality among young Russian men.

Int J Hyg Environ Health 2022 Jun 6;243:113977. Epub 2022 May 6.

Departments of Environmental Health, Boston, USA; Departments of Epidemiology and Boston, USA; Department of Obstetrics, Gynecology and Reproductive Medicine, Harvard Medical School, Boston, USA.

Aim: To prospectively investigate the associations of urinary phthalate metabolite concentrations measured at four time points spanning pubertal development with semen parameters in Russian men.

Design: 516 boys were enrolled at ages 8-9 years (2003-2005) and followed annually.

Methods: Urine samples were collected annually and pooled into four exposure windows [prepuberty, early puberty, late puberty and sexual maturity] based on physician assessed Tanner genitalia stages and testicular volume. Read More

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AIP1 suppresses neovascularization by inhibiting the NOX4-induced NLRP3/NLRP6 imbalance in a murine corneal alkali burn model.

Cell Commun Signal 2022 05 6;20(1):59. Epub 2022 May 6.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, 510060, China.

Background: Apoptosis signal-regulating kinase 1-interacting protein 1 (AIP1) participates in inflammatory neovascularization induction. NADPH oxidase 4 (NOX4) produces reactive oxygen species (ROS), leading to an imbalance in nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) and NLR family pyrin domain containing 6 (NLRP6) expression. The mechanisms of AIP1, NOX4, ROS and inflammasomes in corneal neovascularization were studied herein. Read More

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Cocktail, Sir?

Burns 2022 Jun 18;48(4):1024-1025. Epub 2022 Mar 18.

Burns and Plastic Surgery Department, Royal Manchester Children's Hospital, Oxford Road, Manchester M13 9WL, United Kingdom.

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Effect of topical bovine colostrum in wound healing of corneal surface after acute ocular alkali burn in mice.

Exp Eye Res 2022 Jul 28;220:109093. Epub 2022 Apr 28.

The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. Electronic address:

The purpose of this study was to evaluate the effect of bovine colostrum (BC) in the regeneration of corneal epithelial cells on an ocular alkali burn model. Twenty-four C57BL/6 mice were categorized into two gender/age-matched groups for treatment. Two days after inducing a corneal alkali burn in all left eyes with 4 μl of sodium hydroxide 0. Read More

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Cannabinoid receptor 1 antagonist genistein attenuates marijuana-induced vascular inflammation.

Cell 2022 May 29;185(10):1676-1693.e23. Epub 2022 Apr 29.

Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Radiology, Molecular Imaging Program at Stanford, Stanford University, Stanford, CA 94305, USA; Greenstone Biosciences, Palo Alto, CA 94304, USA. Electronic address:

Epidemiological studies reveal that marijuana increases the risk of cardiovascular disease (CVD); however, little is known about the mechanism. Δ-tetrahydrocannabinol (Δ-THC), the psychoactive component of marijuana, binds to cannabinoid receptor 1 (CB1/CNR1) in the vasculature and is implicated in CVD. A UK Biobank analysis found that cannabis was an risk factor for CVD. Read More

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Assessing the frequency of adverse reactions induced by melanin-containing formulations used for the management of solar dermatitis.

J Cosmet Dermatol 2022 Apr 30. Epub 2022 Apr 30.

Department of Pharmacy, Medical Institute of Yerevan Haybusak University, Yerevan, Armenia.

Background: Melanin from different sources is widely used by many manufacturers to produce cosmetics and sunscreens. Research data show a wide spectrum of biological activities of melanin including the protection against UV radiation and oxidants. According to the research evidence, the topical use of melanin is more effective against inflammation than the hydrocortisone. Read More

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Assault burn injuries in adolescents and adults in South Africa: risk factors and characteristics.

Int J Inj Contr Saf Promot 2022 Apr 27:1-7. Epub 2022 Apr 27.

Institute for Social and Health Sciences, University of South Africa, Pretoria, South Africa.

Assault burns comprise a significant subset of burns, with a greater risk of severe injuries. This South African study used a national dataset from major hospitals to identify risks and injury characteristics of assault burns. The analysis sample comprised 2658 adolescent and adult cases and employed logistic regression with bootstrapping to examine the risk of assault compared to unintentional burns. Read More

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