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    Decreased bacterial growth on titanium nanoscale topographies created by ion beam assisted evaporation.
    Int J Nanomedicine 2017 9;12:1161-1169. Epub 2017 Feb 9.
    Department of Bioengineering, Northeastern University, Boston; Department of Chemical Engineering, Northeastern University, Boston, MA, USA; Center of Excellence for Advanced Materials Research, University of King Abdulaziz, Jeddah, Saudi Arabia.
    Titanium is one of the most widely used materials for orthopedic implants, yet it has exhibited significant complications in the short and long term, largely resulting from poor cell-material interactions. Among these many modes of failure, bacterial infection at the site of implantation has become a greater concern with the rise of antibiotic-resistant bacteria. Nanostructured surfaces have been found to prevent bacterial colonization on many surfaces, including nanotextured titanium. Read More

    Carbon Nanostructures in Bone Tissue Engineering.
    Open Orthop J 2016 30;10:877-899. Epub 2016 Dec 30.
    Reconstructive Surgery & Regenerative Medicine Group, Institute of Life Science (ILS), Swansea University Medical School, Swansea, SA2 8PP, United Kingdom; Welsh Centre for Burns & Plastic Surgery, Abertawe Bro Morgannwg University Health Board, Swansea, United Kingdom.
    Background: Recent advances in developing biocompatible materials for treating bone loss or defects have dramatically changed clinicians' reconstructive armory. Current clinically available reconstructive options have certain advantages, but also several drawbacks that prevent them from gaining universal acceptance. A wide range of synthetic and natural biomaterials is being used to develop tissue-engineered bone. Read More

    Acute respiratory distress syndrome and chemical burns after exposure to chlorine-containing bleach: a case report.
    J Thorac Dis 2017 Jan;9(1):E17-E20
    Department of Internal Medicine, Chonnam National University Hospital, Gwangju, South Korea.
    Chlorine-containing bleach can cause acute respiratory distress syndrome (ARDS) and chemical burns. However, simultaneous occurrence of the two conditions caused by this agent is very rare. We describe the case of a 74-year-old female who presented with shortness of breath and hemoptysis following accidental exposure to chlorine-containing bleach. Read More

    Bromelain Loading and Release from a Hydrogel Formulated Using Alginate and Arabic Gum.
    Planta Med 2017 Feb 14. Epub 2017 Feb 14.
    Faculty of Pharmaceutical Sciences, State University of Campinas (UNICAMP), Campinas, Brazil.
    An ideal wound dressing ensures a moist environment around the wound area and absorbs exudates from the wound surface. Topical application of bromelain to incised wounds has been shown to reprogram the wound microenvironment to promote effective tissue repair. Combining the characteristics of hydrogels and bromelain is therefore of great interest. Read More

    A review of decellurization methods caused by an urgent need for quality control of cell-free extracellular matrix' scaffolds and their role in regenerative medicine.
    J Biomed Mater Res B Appl Biomater 2017 Feb 14. Epub 2017 Feb 14.
    Medical University of Silesia in Katowice, Department of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze.
    The natural extracellular matrix (ECM),thanks to its specific properties (e.g., collagenous lattice, a reservoir of growth factors, ECM-cell anchoring areas, an optimal pH and CO2 ),ensures an optimal microenvironment for homeostatic and regenerative cell development. Read More

    Increase in the radioresistance of normal skin fibroblasts but not tumor cells by mechanical injury.
    Cell Death Dis 2017 Feb 2;8(2):e2573. Epub 2017 Feb 2.
    Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
    The timing of radiation after mechanical injury such as in the case of surgery is considered a clinical challenge because radiation is assumed to impair wound healing. However, the physiological responses and underlying mechanisms of this healing impairment are still unclear. Here, we show that mechanical injury occurring before ionizing radiation decreases radiation-induced cell damage and increases cell repair in normal fibroblasts but not tumor cells in vitro and in vivo. Read More

    Epidemiology of nosocomial fungal infections in the National Center for Burns in Casablanca, Morocco.
    Ann Burns Fire Disasters 2016 Jun;29(2):90-93
    National Center for Burns and Plastic Surgery, University Hospital Ibn Rochd, Casablanca, Morocco.
    Fungal infection is a leading cause of death in burns patients and incurs significant costs for burn units. Our aim was to determine epidemiology of these infections, and analyze risk factors in the burns intensive care unit of the National Center for Burns and Plastic Surgery at Ibn-Rochd University Hospital, Casablanca. It is a retrospective review of all patients admitted from 2011-2014 who developed cultures positive for fungal organisms. Read More

    Long-term outcome of allogeneic cultivated limbal epithelial transplantation for symblepharon caused by severe ocular burns.
    BMC Ophthalmol 2017 Jan 31;17(1). Epub 2017 Jan 31.
    State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, 5 Yanerdao Road, 266071, Qingdao, China.
    Background: The therapeutic effects of allogeneic cultivated limbal epithelial transplantation (CLET) for symblephara at different degrees caused by ocular burns were evaluated in this study.

    Methods: A series of interventional cases were involved in this retrospective study. Eighty eyes (80 patients) with symblephara underwent CLET and the success rates of surgical treatment as well as corneal conditions and risk factors for recurrent symblepharon were analyzed. Read More

    The hypothalamic NPVF circuit modulates ventral raphe activity during nociception.
    Sci Rep 2017 Jan 31;7:41528. Epub 2017 Jan 31.
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, USA.
    RFamide neuropeptide VF (NPVF) is expressed by neurons in the hypothalamus and has been implicated in nociception, but the circuit mechanisms remain unexplored. Here, we studied the structural and functional connections from NPVF neurons to downstream targets in the context of nociception, using novel transgenic lines, optogenetics, and calcium imaging in behaving larval zebrafish. We found a specific projection from NPVF neurons to serotonergic neurons in the ventral raphe nucleus (vRN). Read More

    Search for Dark Matter and Supersymmetry with a Compressed Mass Spectrum in the Vector Boson Fusion Topology in Proton-Proton Collisions at sqrt[s]=8  TeV.
    Phys Rev Lett 2017 Jan 12;118(2):021802. Epub 2017 Jan 12.
    University of Wisconsin-Madison, Madison, WI, USA.
    A first search for pair production of dark matter candidates through vector boson fusion in proton-proton collisions at sqrt[s]=8  TeV is performed with the CMS detector. The vector boson fusion topology enhances missing transverse momentum, providing a way to probe supersymmetry, even in the case of a compressed mass spectrum. The data sample corresponds to an integrated luminosity of 18. Read More

    Chromophores in operative surgery: Current practice and rationalized development.
    J Control Release 2017 Mar 23;249:123-130. Epub 2017 Jan 23.
    Swansea University Medical School, Swansea University, Singleton Campus, UK; The Welsh Centre for Burns and Plastic Surgery, Morriston Hospital, Swansea, UK.
    Background: Chromophore-containing molecules feature extensively in surgical practice, with synthetic dyes gaining popularity over endogenous optical adjuncts. New applications for chromophores in diagnostics and operative treatment exploit unique chemical structures suited for illuminating target tissues beyond the visual spectrum, ranging from ultraviolet (UV) to near-infrared (NIR). This review outlines the rationale for surgical chromophore application, the weaknesses and risks in each class of these compounds, and areas of foreseeable potential for employment of specialized contrast agents. Read More

    Management of a facial partial thickness chemical burn in a dog caused by bleach.
    J Vet Emerg Crit Care (San Antonio) 2017 Jan 24. Epub 2017 Jan 24.
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA, 99164-6610.
    Objective: To describe the management and successful outcome of a late-recognition partial thickness bleach burn to the face and corneas of a dog.

    Case Summary: A 1-year-old male neutered Fox Terrier mix breed dog was evaluated for sloughing facial epithelium 5 days after coming into contact with an 8.25% household bleach cleaning solution. Read More

    Stromal Cell-Derived Growth Factor-1 Alpha-Elastin Like Peptide Fusion Protein Promotes Cell Migration and Revascularization of Experimental Wounds in Diabetic Mice.
    Adv Wound Care (New Rochelle) 2017 Jan;6(1):10-22
    Department of Biomedical Engineering, Rutgers University, Piscataway, New Jersey.; Center for Engineering in Medicine, Massachusetts General Hospital and Shriners Burns Hospital, Boston, Massachusetts.
    Objective: In previous work, we demonstrated the development of a novel fusion protein containing stromal cell-derived growth factor-1 alpha juxtaposed to an elastin-like peptide (SDF1-ELP), which has similar bioactivity, but is more stable in elastase than SDF1. Herein, we compare the ability of a single topical application of SDF1-ELP to that of SDF1 in healing 1 × 1 cm excisional wounds in diabetic mice. Approach: Human Leukemia-60 cells were used to demonstrate the chemotactic potential of SDF1-ELP versus SDF1 in vitro. Read More

    Experimental Study of the Effects of Nanodispersed Ceria on Wound Repair.
    Bull Exp Biol Med 2017 Jan 14;162(3):395-399. Epub 2017 Jan 14.
    N. S. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.
    We studied the effects of nanodispersed ceria on wound healing in vitro and in vivo. It was found that cerium dioxide stimulated wound healing, which manifested in shrinkage of burn wound area (by 1.5 times) and intensification (by 2. Read More

    Pyroglutamate (5-oxoproline) measured with hydrophilic interaction chromatography (HILIC) tandem mass spectrometry in acutely ill patients.
    Clin Chim Acta 2017 Mar 12;466:72-77. Epub 2017 Jan 12.
    Department of Chemical Pathology, Pathology Queensland, Queensland Health, Brisbane, Australia.
    Background: Pyroglutamic acid (PGA) is challenging to quantify in plasma and is a rare cause of metabolic acidosis that is associated with inherited disorders or acquired after exposure to drugs.

    Method: We developed a hydrophilic interaction liquid chromatography tandem mass spectrometry method with a short analysis time. We established a reference interval and then measured PGA in acutely ill patients to investigate associations with clinical, pharmaceutical and laboratory parameters. Read More

    Integrated, High-Throughput, Multiomics Platform Enables Data-Driven Construction of Cellular Responses and Reveals Global Drug Mechanisms of Action.
    J Proteome Res 2017 Feb 9. Epub 2017 Feb 9.
    Biomedical Engineering, Vanderbilt University School of Engineering , Nashville, Tennessee 37235, United States.
    An understanding of how cells respond to perturbation is essential for biological applications; however, most approaches for profiling cellular response are limited in scope to pre-established targets. Global analysis of molecular mechanism will advance our understanding of the complex networks constituting cellular perturbation and lead to advancements in areas, such as infectious disease pathogenesis, developmental biology, pathophysiology, pharmacology, and toxicology. We have developed a high-throughput multiomics platform for comprehensive, de novo characterization of cellular mechanisms of action. Read More

    A novel role of topical iodine in skin: Activation of the Nrf2 pathway.
    Free Radic Biol Med 2017 Mar 12;104:238-248. Epub 2017 Jan 12.
    The Institute for Drug Research, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem 9112100, Israel. Electronic address:
    For a long time iodine has been used as an active dermal agent in the treatment of inflammatory, immune-mediated and infectious diseases. Moreover, topical iodine application has been reported to provide protection against sulfur-mustard-induced skin lesions, heat-induced and acid-induced skin burns in both haired guinea-pigs and mouse ear swelling models. However, the exact mechanism of action underlying these benefits of iodine has not yet been elucidated. Read More

    The unusual presentation of a burn from methyl bromide exposure: A case report and review of the literature.
    Burns 2017 Jan 6. Epub 2017 Jan 6.
    Regional Burn Center, Santa Clara Valley Medical Center, San Jose, CA, United States; Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, CA, United States.
    Methyl bromide chemical burns are rare. Only two cases have been reported to date. The presentation of methyl bromide chemical burns is unusual. Read More

    Avoiding Chlorhexidine Burns in Preterm Infants.
    J Obstet Gynecol Neonatal Nurs 2017 Jan 6. Epub 2017 Jan 6.
    Chlorhexidine is a skin antiseptic agent frequently used for off-label indications in NICUs. Changes to the safety labeling of chlorhexidine products for use in preterm infants were recently made because of the risk of severe chemical burns. We provide tips for a safer use of chlorhexidine to prevent injury in newborns and to help health care professionals protect themselves against burn injury claims. Read More

    Chemical burn to the gingiva after misuse of an over-the-counter oral whitening mouthwash.
    Gen Dent 2017 Jan-Feb;65(1):34-36
    A well-recognized consequence of the use of tooth whitening gels and strips, particularly prescription strength formulations, is gingival irritation and tooth sensitivity. Limited information is available in the literature on the risk of gingival chemical burns associated with over-the-counter (OTC) oral whitening rinses. This case report details the development of gingival chemical burns consequent to misuse of a whitening rinse. Read More

    Cyanoacrylate Burn Injuries: Two Unusual Cases and a Review of the Literature.
    Wounds 2016 Dec;28(12):E53-E59
    Burns Unit, Chelsea and Westminster Hospital, London, UK.
    The authors present 2 cases of cyanoacrylate glue ("Super Glue") burns, with a review of the literature and a discussion on the mechanism of action. The authors found all reported cases were with domestic - not medical-grade - cyanoacrylate glue in the presence of cotton fabric. Often erroneously designated as chemical burns, they are thermal burns caused by an intensive exothermic reaction. Read More

    [Investigation of emergency capacities for occupational hazard accidents in silicon solar cell producing enterprises].
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2016 Nov;34(11):819-821
    Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China.
    Objective: To investigate and analyze the influential factors of occupational hazard acci-dents, emergency facilities and emergency management in Silicon solar cell producing enterprises, then to pro-vide scientific strategies. Methods: The methods of occupationally healthy field investigating, inspecting of ven-tilation effectiveness, setup of emergency program and wearing chemical suit were used. Results: The mainly occupational hazard accidents factors in the process of Silicon solar cell producing included poisoning chemi-cals, high temperature, onizing radiation and some workplaces. Read More

    Keeping pace with the media; Giant Hogweed burns - A case series and comprehensive review.
    Burns 2016 Dec 29. Epub 2016 Dec 29.
    Burns & Plastic Surgery Department, University Hospital South Manchester, Southmoor Road, Wythenshawe, Manchester M23 9LT, United Kingdom; Burns & Plastic Surgery Department, Royal Manchester Children's Hospital, Oxford Road, Manchester M139WL, United Kingdom.
    Phytophotodermatitis is almost exclusively reported in the dermatological literature, but may progress to a chemical burn. There has been widespread media reporting during the summer of 2015 of burns caused by giant hogweed. However, there is a lack of awareness of this mechanism of injury amongst the burn multidisciplinary team, and there have been no published articles in the surgical literature regarding plant burns, other than sporadic case reports, for 20 years. Read More

    Acute intestinal damage following severe burn correlates with the development of multiple organ dysfunction syndrome: A prospective cohort study.
    Burns 2016 Dec 28. Epub 2016 Dec 28.
    Department of Trauma, Critical Care Medicine and Burn Center, Japan Community Healthcare Organization Chukyo Hospital, Nagoya, Japan.
    Background: Severely burned patients occasionally suffer intestinal ischemia leading to a fatal outcome, and the gut is considered a "motor" driving the development of multiple organ failure. However, in clinical settings, it has been difficult to assess acute intestinal damage following burn and its consequence to patient outcome. Intestinal fatty acid binding protein (I-FABP) is a known biomarker for diagnosing intestinal ischemia/damage. Read More

    Wound-healing promoting effect of total tannins from Entada phaseoloides (L.) Merr. in rats.
    Burns 2016 Dec 28. Epub 2016 Dec 28.
    College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, PR China. Electronic address:
    The healing of wounds has always provided challenges for the medical community whether chronic or acute. Modern and traditional medicine has proved that herbal medicine shown superiority over chemical drugs. Herein, we report an Entada phaseoloides (L. Read More

    Antidepressant-like effects of ginsenoside Rg3 in mice via activation of the hippocampal BDNF signaling cascade.
    J Nat Med 2016 Dec 24. Epub 2016 Dec 24.
    Department of Burns and Plastic Surgery, Taizhou People's Hospital, The Fifth Affiliated Hospital of Medical College of Nantong University, No. 210 Yingchun Road, Taizhou, 225300, Jiangsu, China.
    Current antidepressants are clinically effective only after several weeks of administration. Ginsenoside Rg3 is one component of ginsenosides, with a similar chemical structure to ginsenoside Rg1. Here, we investigated the antidepressant effects of Rg3 in mouse models of depression. Read More

    Serum stearic acid/palmitic acid ratio as a potential predictor of diabetes remission after Roux-en-Y gastric bypass in obesity.
    FASEB J 2016 Dec 22. Epub 2016 Dec 22.
    Shanghai Key Laboratory of Diabetes Mellitus and Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China;
    Endogenous fatty acid metabolism that results in elongation and desaturation lipid products is thought to play a role in the development of type 2 diabetes mellitus (T2DM). In this study, we evaluated the potential of estimated elongase and desaturase activities for use as predictive markers for T2DM remission after Roux-en-Y gastric bypass (RYGB). The results of a targeted metabolomics approach from 2 independent studies were used to calculate 24 serum FA concentration ratios (product/precursor). Read More

    Inter-platform concordance of gene expression data for the prediction of chemical mode of action.
    Biol Direct 2016 Dec 20;11(1):67. Epub 2016 Dec 20.
    Department of Biostatistics, University of Florida, Gainesville, 32603, FL, USA.
    Background: It is interesting to study the consistency of outcomes arising from two genomic platforms: Microarray and RNAseq, which are established on fundamentally different technologies. This topic has been frequently discussed from the prospect of comparing differentially expressed genes (DEGs). In this study, we explore the inter-platform concordance between microarray and RNASeq in their ability to classify samples based on genomic information. Read More

    Microbiological and epidemiological study of infectious keratitis in children and adolescents.
    Arq Bras Oftalmol 2016 Sep-Oct;79(5):289-293
    Departamento de Infectologia, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
    Purpose:: To analyze epidemiological and microbiological aspects of microbial keratitis in children and adolescents.

    Methods:: This retrospective cohort study was conducted at the Department of Ophthalmology and Visual Science, Escola Paulista de Medicina, Universidade Federal de São Paulo, between July 15, 1975, and December 31, 2010. We analyzed corneal samples from 859 patients with clinical suspicion of infectious keratitis, comparing epidemiological and microbiological characteristics of bacterial keratitis with those of non-bacterial and non-viral keratitis. Read More

    Hydrofluoric acid burns in the western Zhejiang Province of China: a 10-year epidemiological study.
    J Occup Med Toxicol 2016 7;11:55. Epub 2016 Dec 7.
    Department of Burns & Wound Care Center, Second Affiliated Hospital of Zhejiang University College of Medicine, Hangzhou, 310009 China.
    Background: Chemical burns caused by hydrofluoric acid (HF) frequently occur in the Western Zhejiang Province. This study aimed to investigate the epidemiological characteristics of HF burns within this region.

    Methods: A 10-year retrospective analysis was conducted using data from all inpatients with HF burns. Read More

    Chemical Synthesis and Self-Assembly of a Ladderane Phospholipid.
    J Am Chem Soc 2016 Dec 29;138(49):15845-15848. Epub 2016 Nov 29.
    Department of Chemistry, Stanford University , Stanford, California 94305, United States.
    Ladderane lipids produced by anammox bacteria constitute some of the most structurally fascinating yet poorly studied molecules among biological membrane lipids. Slow growth of the producing organism and the inherent difficulty of purifying complex lipid mixtures have prohibited isolation of useful amounts of natural ladderane lipids. We have devised a highly selective total synthesis of ladderane lipid tails and a full phosphatidylcholine to enable biophysical studies on chemically homogeneous samples of these molecules. Read More

    Ocular traumas in working age adults in Finland - Helsinki Ocular Trauma Study.
    Acta Ophthalmol 2016 Dec 9. Epub 2016 Dec 9.
    Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
    Purpose: To describe epidemiology, causes, treatments and outcomes of ocular injuries in adults aged 17 to 60 in southern Finland.

    Methods: All new ocular trauma patients admitted to the Helsinki University Eye Hospital (HUEH), during 1 year in 2011-2012. The data were from hospital records and prospectively from patient questionnaires. Read More

    Targeted killing of myofibroblasts by biosurfactant di-rhamnolipid suggests a therapy against scar formation.
    Sci Rep 2016 Nov 30;6:37553. Epub 2016 Nov 30.
    College of Chemical and Biological Engineering, Zhejiang University, Hangzhou, PR China.
    Pathological myofibroblasts are often involved in skin scarring via generating contractile force and over-expressing collagen fibers, but no compound has been found to inhibit the myofibroblasts without showing severe toxicity to surrounding physiological cells. Here we report that di-rhamnolipid, a biosurfactant secreted by Pseudomonas aeruginosa, showed potent effects on scar therapy via a unique mechanism of targeted killing the myofibroblasts. In cell culture, the fibroblasts-derived myofibroblasts were more sensitive to di-rhamnolipid toxicity than fibroblasts at a concentration-dependent manner, and could be completely inhibited of their specific functions including α-SMA expression and collagen secretion/contraction. Read More

    Pre-expanded Bipedicled Supratrochlear Perforator Flap for Simultaneous Reconstruction of the Nasal and Upper Lip Defects.
    Clin Plast Surg 2017 Jan;44(1):153-162
    Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhi Zao Ju Road, Shanghai 200011, P.R. China. Electronic address:
    The double "S" principle should be followed for facial reconstruction: the "similarity" of the donor site to the defect area and the reconstruction should be based on the different "subunits" of the face. In this article the pre-expanded, bipedicled supratrochlear perforator flap method is described, which is used for the resurfacing of both nasal and upper lip defects. This method can provide 2 independent flaps with sufficient tissue from 1 single donor site, resurfacing the nasal and upper lip units separately and providing an unparalleled color and texture match and ideal reconstructive result. Read More

    Helicopter Transport in Regionalized Burn Care: One Program's Perspective.
    Air Med J 2016 Nov - Dec;35(6):355-359. Epub 2016 Nov 10.
    Department of Emergency Medicine, Virginia Commonwealth University, Richmond, VA.
    Background: The decision to use helicopter EMS (HEMS) for the transport of burn patients is a complex decision. This analysis sought to evaluate burn patients flown to burn centers who met predetermined criteria for patients who likely benefit from HEMS care.

    Methods: A retrospective transport chart review of all burn transports covering the preceding nine and a half years was conducted to evaluate for HEMS appropriate criteria defined as patients requiring advanced airway management, ventilator support, facial burns, inhalation injury, circumferential burns, electrical or chemical burn, or major burns. Read More

    Globularia alypum methanolic extract improves burn wound healing process and inflammation in rats and possesses antibacterial and antioxidant activities.
    Biomed Pharmacother 2016 Dec 19;84:1488-1495. Epub 2016 Nov 19.
    Research Unit of Pharmacology and Toxicology of Xenobiotics, Faculty of Medicine, University of Sfax, 3029, Sfax, Tunisie.
    Burns are known as one of the most common and destructive forms of injury with a vast spectrum of consequences. Despite the discovery of various antibacterial and antiseptic agents, burn wound healing still has remained a challenge to modern medicine. Plants have been considered as potential agents for prevention and treatment of disorders in recent years. Read More

    Clinical and demographic features of burn injuries in karachi: a six-year experience at the burns centre, civil hospital, Karachi.
    Ann Burns Fire Disasters 2016 Mar;29(1):4-9
    Department of Biostatistics and Research, Dow University of Health Sciences, Karachi, Pakistan.
    Burn injuries are a leading cause of morbidity and mortality, with 195,000 deaths annually. This study was conducted to identify the demographics of burn victims and the effect of different variables on the outcome of their injuries. 4016 patients admitted to the Burns Centre, Civil Hospital Karachi from January 2006 to December 2011 were retrospectively analyzed. Read More

    Clinical study of burn patients requiring admission: A single center experience at North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences.
    J Family Med Prim Care 2016 Apr-Jun;5(2):444-448
    Department of General Surgery, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.
    Background: Although burns are a major problem in health care, a lot of the variation in risk factors exists from region to region which if uncovered correctly could help take effective prevention measures.

    Aims And Objectives: To assess the 3-year (January 2012 to January 2015) epidemiology of burn injuries admitted to our hospital (primary objective) and to find areas of improvement in burn care (secondary objective).

    Materials And Methods: After obtaining ethical approval data were obtained from the medical record section regarding age, sex, residence, occupation, marital status, socioeconomic status, dates of admission and discharge, circumstances regarding the place, intent, cause, and source of heat. Read More

    Chiral Alkyl Halides: Underexplored Motifs in Medicine.
    Mar Drugs 2016 Nov 4;14(11). Epub 2016 Nov 4.
    Department of Chemistry, Stanford University, 333 Campus Drive, Stanford, CA 94305, USA.
    While alkyl halides are valuable intermediates in synthetic organic chemistry, their use as bioactive motifs in drug discovery and medicinal chemistry is rare in comparison. This is likely attributable to the common misconception that these compounds are merely non-specific alkylators in biological systems. A number of chlorinated compounds in the pharmaceutical and food industries, as well as a growing number of halogenated marine natural products showing unique bioactivity, illustrate the role that chiral alkyl halides can play in drug discovery. Read More

    Functional Rescue of ABCC6 Deficiency by 4-Phenylbutyrate Therapy Reduces Dystrophic Calcification in Abcc6(-/-) Mice.
    J Invest Dermatol 2017 Mar 5;137(3):595-602. Epub 2016 Nov 5.
    Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA. Electronic address:
    Soft-tissue calcification is associated with aging, common conditions such as diabetes or hypercholesterolemia, and with certain genetic disorders. ABCC6 is an efflux transporter primarily expressed in liver facilitating the release of adenosine triphosphate from hepatocytes. Within the liver vasculature, adenosine triphosphate is converted into pyrophosphate, a major inhibitor of ectopic calcification. Read More

    [Endoscopic treatment of cicatricial esophageal strictures using ionized argon plasma (with commentary)].
    Khirurgiia (Mosk) 2016(10):16-20
    Department of Hospital Surgery, Chita State Medical Academy, Chita, Russia.
    Aim: To estimate an efficacy of endoscopic treatment of benign cicatricial esophageal strictures using ionized argon plasma.

    Material And Methods: It is presented treatment of 35 patients with post-ambustial and 17 patients with peptic strictures of the esophagus. Their age ranged from 17 to 73 years. Read More

    Clinical Spectrum and Treatment Approaches in Corneal Burns.
    Turk J Ophthalmol 2015 Oct 5;45(5):182-187. Epub 2015 Oct 5.
    Dünya Eye Hospital, Ankara, Turkey.
    Objectives: To evaluate the clinical findings, treatment modalities and long-term prognosis of chemical and thermal burns of the cornea.

    Materials And Methods: Twenty-one patients (27 eyes) who were followed at two centers for corneal chemical and thermal burns between 2001 and 2013 were included. Eyes were grouped into four grades according to the severity of burn using Roper-Hall classification. Read More

    Molecular Characterization of Brown Carbon in Biomass Burning Aerosol Particles.
    Environ Sci Technol 2016 Nov 18;50(21):11815-11824. Epub 2016 Oct 18.
    Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99354, United States.
    Emissions from biomass burning are a significant source of brown carbon (BrC) in the atmosphere. In this study, we investigate the molecular composition of freshly emitted biomass burning organic aerosol (BBOA) samples collected during test burns of sawgrass, peat, ponderosa pine, and black spruce. We demonstrate that both the BrC absorption and the chemical composition of light-absorbing compounds depend significantly on the type of biomass fuels. Read More

    [The role of neutrophil myeloperoxidase in the development of inflammation after thermal skin burns].
    Biomed Khim 2016 Jul;62(5):584-587
    Federal Scientific Clinical Centre of Physical Chemical Medicine, Moscow, Russia.
    In the blood of children (n=16) with large thermal skin burns (> 20% of total body surface), luminol-dependent chemiluminescence (CL) of neutrophils stimulated with phorbol-12-myristate-13-acetate (PMA) and myeloperoxidase (MPO) activity in neutrophils and plasma were assayed in the early period (1-7 post-burn days). PMA-stimulated neutrophils in thermally injured patients produced higher CL than those in a reference group of healthy children (n=24), p<0.01. Read More

    Large-scale expansion of human skin-derived precursor cells (hSKPs) in stirred suspension bioreactors.
    Biotechnol Bioeng 2016 Dec 11;113(12):2725-2738. Epub 2016 Jul 11.
    Pharmaceutical Production Research Facility (PPRF), Schulich School of Engineering, University of Calgary, Calgary, Alberta, Canada.
    Human skin-derived precursor cells (hSKPs) are multipotent adult stem cells found in the dermis of human skin. Incorporation of hSKPs into split-thickness skin grafts (STSGs), the current gold standard to treat severe burns or tissue resections, has been proposed as a treatment option to enhance skin wound healing and tissue function. For this approach to be clinically viable substantial quantities of hSKPs are required, which is the rate-limiting step, as only a few thousand hSKPs can be isolated from an autologous skin biopsy without causing donor site morbidity. Read More

    Ann Burns Fire Disasters 2015 Dec;28(4):243-246
    Centre National des Brûlés et de Chirurgie Plastique, CHU Ibn Rochd, Casablanca, Morocco.
    Hand burns in children are common and may lead to debilitating sequelae. Therefore, full functional restoration of the hand is the goal of treatment. To assess the epidemiological, clinical and development aspects of the burns, we conducted a retrospective study over 4 years, from January 2011 to January 2015. Read More

    Why burn patients are referred?
    Burns 2016 Oct 12. Epub 2016 Oct 12.
    Faculty of Medicine, Motahary Burn Hospital, School of Medicine, Burn Research Center, Iran University of Medical Sciences, Yasemi Alley, Vali Asr Ave., Tehran 19637, Iran. Electronic address:
    Background: Many burn patients are needed to be referred to a tertiary burn hospital according to the American Burn Association (ABA) criteria. The purpose of this study was to verify the reasons for referring of the burn patients to the hospital.

    Materials And Methods: For 2 years, we prospectively surveyed the burn patients referred to a tertiary teaching burn hospital. Read More

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