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    Glaucoma after chemical burns and radiation.
    Rom J Ophthalmol 2016 Oct-Dec;60(4):209-215
    Ophthalmology Department, "Dr. Carol Davila" Central Military Emergency University Hospital, Bucharest, Romania.
    Glaucoma after chemical burns represents a posttraumatic glaucoma, usually open-angle glaucoma. It is a frequent complication of chemical burns, especially with alkali and it can appear in the acute stage or as a late complication. Because of the complications and scars, the treatment is very difficult. Read More

    Chemical Sensor Systems and Associated Algorithms for Fire Detection: A Review.
    Sensors (Basel) 2018 Feb 11;18(2). Epub 2018 Feb 11.
    Department of Electronic and Biomedical Engineering, Universitat de Barcelona, 08028 Barcelona, Spain.
    Indoor fire detection using gas chemical sensing has been a subject of investigation since the early nineties. This approach leverages the fact that, for certain types of fire, chemical volatiles appear before smoke particles do. Hence, systems based on chemical sensing can provide faster fire alarm responses than conventional smoke-based fire detectors. Read More

    Treatment with silver nitrate versus topical steroid treatment for umbilical granuloma: A non-inferiority randomized control trial.
    PLoS One 2018 13;13(2):e0192688. Epub 2018 Feb 13.
    Department of Pediatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan.
    Objective: The aim of this prospective multicenter randomized controlled trial was to compare the efficacy of silver nitrate cauterization against that of topical steroid ointment in the treatment of neonatal umbilical granuloma.

    Methods: An open-label, non-inferiority randomized controlled trial was conducted from January 2013 to January 2016. The primary endpoint for the silver nitrate cauterization and topical steroid ointment groups was the healing rate after 2 weeks of treatment, applying a non-inferiority margin of 10%. Read More

    Characterization of Gas-Phase Organics Using Proton Transfer Reaction Time-of-Flight Mass Spectrometry: Residential Coal Combustion.
    Environ Sci Technol 2018 Feb 13. Epub 2018 Feb 13.
    Laboratory of Atmospheric Chemistry, Paul Scherrer Institute , Villigen, 5232, Switzerland.
    Residential coal combustion is a significant contributor to particulate urban air pollution in Chinese mega cities and some regions in Europe. While the particulate emission factors and the chemical characteristics of the organic and inorganic aerosol from coal combustion have been extensively studied, the chemical composition and nonmethane organic gas (NMOG) emission factors from residential coal combustion are mostly unknown. We conducted 23 individual burns in a traditional Chinese stove used for heating and cooking using five different coals with Chinese origins, characterizing the NMOG emissions using a proton transfer reaction time-of-flight mass spectrometer. Read More

    Phytotherapeutic Activities of Sanguisorba officinalis and its Chemical Constituents: A Review.
    Am J Chin Med 2018 Feb 12:1-20. Epub 2018 Feb 12.
    * College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
    Sanguisorba officinalis Linne (S. officinalis, Rosaceae) has been used as a medicinal plant for the treatment of burns, hematemesis, melena, intestinal infections, and dermatitis for a long time in China, Korea, and Japan. The therapeutic efficacy of this herb is intimately associated with its anti-oxidant, anti-inflammatory, antiviral, antifungal, hemostatic, and anticancer activities. Read More

    Gasoline-related injuries and fatalities in the United States, 1995-2014.
    Int J Inj Contr Saf Promot 2018 Feb 12:1-8. Epub 2018 Feb 12.
    a Drago Expert Services , Plymouth , MA 02360 , USA.
    This descriptive study examines twenty years of gasoline-related fatalities and emergency department treated injuries in the United States, based on data from the US Consumer Product Safety Commission. Thermal burns consistently accounted for the majority (56%) of gasoline-related injuries and for most (82%) gasoline-related deaths, and were commonly (57-71%) associated with the use of gasoline as an accelerant. Poisoning accounted for 13% of injuries and 17% of deaths. Read More

    Structuring of Hydrogels across Multiple Length Scales for Biomedical Applications.
    Adv Mater 2018 Feb 12. Epub 2018 Feb 12.
    School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
    The development of new materials for clinical use is limited by an onerous regulatory framework, which means that taking a completely new material into the clinic can make translation economically unfeasible. One way to get around this issue is to structure materials that are already approved by the regulator, such that they exhibit very distinct physical properties and can be used in a broader range of clinical applications. Here, the focus is on the structuring of soft materials at multiple length scales by modifying processing conditions. Read More

    Treatment of corneal chemical alkali burns with a crosslinked thiolated hyaluronic acid film.
    Burns 2018 Feb 8. Epub 2018 Feb 8.
    Department of Sensory Trauma, United States Army Institute of Surgical Research, San Antonio, TX 78234, United States.
    Purpose: The study objective was to test the utilization of a crosslinked, thiolated hyaluronic acid (CMHA-S) film for treating corneal chemical burns.

    Methods: Burns 5.5mm in diameter were created on 10 anesthetized, male New Zealand white rabbits by placing a 1N NaOH soaked circular filter paper onto the cornea for 30s. Read More

    Nose resurfacing with free fasciocutaneous flaps in burns patients.
    Microsurgery 2018 Feb 10. Epub 2018 Feb 10.
    Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, Linko, Taiwan.
    Background: Nasal reconstruction after burn injury can be challenging due to limited availability of local flaps. We present our experience of free flap reconstruction for full-thickness nasal defect after severe facial burn injury.

    Methods: Between August 1998 and September 2015, six patients underwent nasal reconstruction with seven free flaps after burn injury. Read More

    A Rare Case of Anal and Perianal Chemical Burn in a Child due to Potassium Permanganate Crystals.
    Drug Saf Case Rep 2018 Feb 9;5(1):10. Epub 2018 Feb 9.
    Department of Burns, Plastic and Maxillofacial Surgery, Vardhman Mahavir Medical College and Safdarjung Hospital, H 2, First Floor, Green Park Main, New Delhi, 110016, India.
    Many chemicals used as medical treatments can cause chemical burns as an untoward side effect. One of such chemicals is potassium permanganate. It is a caustic chemical used as a disinfectant. Read More

    Oral mucosa grafting in periorbital reconstruction.
    Orbit 2018 Feb 6:1-18. Epub 2018 Feb 6.
    a Corneoplastic Unit , Queen Victoria Hospital NHS Foundation Trust , East Grinstead , UK.
    To provide an extensive literature review on the clinical indications of oral mucosa grafts (OMG) and minor salivary gland grafts (MSGG) in periorbital reconstruction together with safe practice graft harvesting techniques to minimize donor-site morbidity. A literature review was performed by searching the databases of PUBMED, EMBASE, and COCHRANE library using the keywords: minor salivary glands; oral mucosal graft; orbit; and eye. The bibliographies of the pertinent articles were examined for additional papers. Read More

    MicroRNA-296 mediated corneal neovascularization in an animal model of corneal burns after alkali exposures.
    Exp Ther Med 2018 Jan 31;15(1):139-144. Epub 2017 Oct 31.
    Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.
    Alkali burns of the cornea may lead to permanent visual impairment or complete blindness. In the current study, the role of microRNA 296 (miR-296) was explored in mouse corneal neovascularization induced by alkali burns. An alkali burn model in Balb/c mice was developed to study chemical corneal injuries. Read More

    DifferentialBiological Action, Coregulator Interactions, and Molecular Dynamic Analysis of Bisphenol A (BPA), BPAF, and BPS Ligand-ERα Complexes.
    Environ Health Perspect 2018 Jan 31;126(1):017012. Epub 2018 Jan 31.
    Reproductive and Developmental Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.
    Background: Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) that might be harmful to human health. Recently, there has been widespread usage of bisphenol chemicals (BPs), such as bisphenol AF (BPAF) and bisphenol S (BPS), as replacements for BPA. However, the potential biological actions, toxicity, and the molecular mechanism of these compounds are still poorly understood. Read More

    One-Way Particle Transport Using Oscillatory Flow in Asymmetric Traps.
    Small 2018 Jan 29. Epub 2018 Jan 29.
    Department of Chemical Engineering, University of Michigan at Ann Arbor, 3074 H. H. Dow, 2300 Hayward St, Ann Arbor, MI, 48109, USA.
    One challenge of integrating of passive, microparticles manipulation techniques into multifunctional microfluidic devices is coupling the continuous-flow format of most systems with the often batch-type operation of particle separation systems. Here, a passive fluidic technique-one-way particle transport-that can conduct microparticle operations in a closed fluidic circuit is presented. Exploiting pass/capture interactions between microparticles and asymmetric traps, this technique accomplishes a net displacement of particles in an oscillatory flow field. Read More

    Maternal exposure to UV filters and associations to maternal thyroid hormones and IGF-I/IGFBP3 and birth outcomes.
    Endocr Connect 2018 Jan 23. Epub 2018 Jan 23.
    A Andersson, Dep. of Growth and Reproduction, section 5064, Blegdamsvej 9, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
    Background: Several chemical UV filters/absorbers (in the following called UV filters) have endocrine disrupting properties in vitro and in vivo. Exposure to these chemicals, especially during prenatal development, is of concern.

    Objectives: To examine maternal exposure to UV filters and associations to maternal thyroid hormone and growth factor concentrations as well as to birth outcomes. Read More

    Bioactivity-Guided Screening of Wound-Healing Active Constituents from American Cockroach (Periplaneta americana).
    Molecules 2018 Jan 20;23(1). Epub 2018 Jan 20.
    Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, China.
    Ethanol extract (EE) from(PA) is the main ingredient of Kangfuxin, which is a popular traditional chinese medicine (TCM) and has long been used for the clinical treatment of burns, wounds and ulcers. We compared the wound-healing activities of three extracts of PA using cutaneous wound-healing in mice as the bioactivity model. These three extracts were EE, total polysaccharide and total protein. Read More

    Essential oil-loaded lipid nanoparticles for wound healing.
    Int J Nanomedicine 2018 27;13:175-186. Epub 2017 Dec 27.
    Department of Drug Sciences, University of Pavia, Pavia.
    Chronic wounds and severe burns are diseases responsible for severe morbidity and even death. Wound repair is a crucial process and tissue regeneration enhancement and infection prevention are key factors to minimize pain, discomfort, and scar formation. The aim of this work was the development of lipid nanoparticles (solid lipid nanoparticles and nanostructured lipid carriers [NLC]), to be loaded with eucalyptus or rosemary essential oils and to be used, as medical devices, to enhance healing of skin wounds. Read More

    Feasibility of developing a passive sampler for sampling heavy metals in BMPs for stormwater runoff management.
    Environ Technol 2018 Feb 2:1-8. Epub 2018 Feb 2.
    e Department of Chemical and Biochemical Engineering , University of Iowa , Iowa City , IA , USA.
    Structural Best Management Practices (BMPs) have been used for stormwater treatment and management for several decades. How to monitor these BMPs performance reliably and economically is a challenge. This paper reports the feasibility of developing a flow through passive sampler (PS) based on Amberlite IRC748 ion exchange resin operated in kinetic regime for sampling heavy metals in BMPs (infiltration systems) for stormwater treatment and management. Read More

    Extracorporeal membrane oxygenation combined with continuous renal replacement therapy in cutaneous burn and inhalation injury caused by hydrofluoric acid and nitric acid.
    Medicine (Baltimore) 2017 Dec;96(48):e8972
    Department of Critical Care Medicine, Suzhou Municipal Hospital Affiliated to Nanjing Medical University, Suzhou, China.
    Rationale: Hydrofluoric acid (HF) is a highly corrosive agent and can cause corrosive burns. HF can penetrate deeply into tissues through intact skin and the lipid barrier, leading to painful liquefactive necrosis, and inducing hypocalcemia and hypomagnesemia. In this study, we hypothesize that continuous renal replacement therapy (CRRT) may be beneficial in addressing hemodynamic instability in cases of HF poisoning. Read More

    Irritant contact keratitis caused by the bodily fluids of a brown marmorated stink bug.
    Taiwan J Ophthalmol 2017 Oct-Dec;7(4):221-223
    Department of Ophthalmology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
    Purpose: The brown marmorated stink bug is native to Asia (China, Taiwan, Japan, and the Korean peninsula). Its bodily fluids are toxic and irritating to the human skin and eyes. Human case reports are rare. Read More

    Search for Evidence of the Type-III Seesaw Mechanism in Multilepton Final States in Proton-Proton Collisions at sqrt[s]=13  TeV.
    Phys Rev Lett 2017 Dec 1;119(22):221802. Epub 2017 Dec 1.
    University of Wisconsin-Madison, Madison, WI, USA.
    A search for a signal consistent with the type-III seesaw mechanism in events with three or more electrons or muons is presented. The data sample consists of proton-proton collisions at sqrt[s]=13  TeV collected by the CMS experiment at the LHC in 2016 and corresponds to an integrated luminosity of 35.9  fb^{-1}. Read More

    Observation of Top Quark Production in Proton-Nucleus Collisions.
    Phys Rev Lett 2017 Dec 14;119(24):242001. Epub 2017 Dec 14.
    University of Wisconsin - Madison, Madison, Wisconsin, Wisconsin, USA.
    The first observation of top quark production in proton-nucleus collisions is reported using proton-lead data collected by the CMS experiment at the CERN LHC at a nucleon-nucleon center-of-mass energy of sqrt[s_{NN}]=8.16  TeV. The measurement is performed using events with exactly one isolated electron or muon candidate and at least four jets. Read More

    Microstructured Devices for Optimized Microinjection and Imaging of Zebrafish Larvae.
    J Vis Exp 2017 Dec 8(130). Epub 2017 Dec 8.
    BioMEMS Resource Center, Department of Surgery, Massachusetts General Hospital-Harvard Medical School-Shriners Burns Hospital.
    Zebrafish have emerged as a powerful model of various human diseases and a useful tool for an increasing range of experimental studies, spanning fundamental developmental biology through to large-scale genetic and chemical screens. However, many experiments, especially those related to infection and xenograft models, rely on microinjection and imaging of embryos and larvae, which are laborious techniques that require skill and expertise. To improve the precision and throughput of current microinjection techniques, we developed a series of microstructured devices to orient and stabilize zebrafish embryos at 2 days post fertilization (dpf) in ventral, dorsal, or lateral orientation prior to the procedure. Read More

    Results of simple limbal epithelial transplantation in unilateral ocular surface burn.
    Indian J Ophthalmol 2018 Jan;66(1):45-52
    Department of Cornea, External Diseases and Refractive Surgery, Dr. Shroff's Charity Eye Hospital, New Delhi, India.
    Purpose: This study aimed to report the long-term outcomes of autologous Simple Limbal Epithelial Transplantation (SLET) performed for unilateral limbal stem cell deficiency (LSCD) following chemical burn at a tertiary eye center in North India.

    Methods: This was a single-center prospective interventional case series of patients who developed unilateral LSCD after suffering from ocular surface burns and who underwent SLET between October 2012 and May 2016 with a follow-up period of at least 6 months. The primary outcome measure was restoration of a completely epithelized, stable, and avascular corneal surface. Read More

    Adjuvant Photothermal Therapy Inhibits Local Recurrences after Breast-Conserving Surgery with Little Skin Damage.
    ACS Nano 2018 Jan 28;12(1):662-670. Epub 2017 Dec 28.
    Department of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University , Nanjing 210002, P. R. China.
    Adjuvant treatments following breast-conserving surgery (BCS) are essential to reduce the risk of local recurrences in patients with breast cancer. However, current adjuvant treatments are based on ionizing radiation, which brings radiation-induced damage and amplifies the risk of death. Here we explore the feasibility of using non-ionizing light to induce photothermal therapy as an adjuvant treatment to BCS. Read More

    Biomaterials for Skin Substitutes.
    Adv Healthc Mater 2017 Dec 22. Epub 2017 Dec 22.
    Sunnybrook Research Institute, University of Toronto, Toronto, ON, Canada.
    Patients with extensive burns rely on the use of tissue engineered skin due to a lack of sufficient donor tissue, but it is a challenge to identify reliable and economical scaffold materials and donor cell sources for the generation of a functional skin substitute. The current review attempts to evaluate the performance of the wide range of biomaterials available for generating skin substitutes, including both natural biopolymers and synthetic polymers, in terms of tissue response and potential for use in the operating room. Natural biopolymers display an improved cell response, while synthetic polymers provide better control over chemical composition and mechanical properties. Read More

    Polyelectrolyte-complex multilayer membrane with gradient porous structure based on natural polymers for wound care.
    Carbohydr Polym 2018 Feb 23;181:183-190. Epub 2017 Oct 23.
    Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing 100029, PR China. Electronic address:
    Chitosan and alginate have been considered to be promising natural polymers for biomedical application because of their biocompatibility, biodegradability and similarity to macromolecules recognized by human body, which are extensively used in wounds and burns management. Here a sponge-like polyelectrolyte-complex multilayer membrane (PCMM) was prepared via freeze-drying method. The attenuated total reflectance fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS) and field emission scanning electron microscopy (FE-SEM) analysis revealed that chitosan/alginate layer exhibited gradient porous structure and interpenetrating polymer networks in PCMM. Read More

    Hemin immobilized into metal-organic frameworks as an electrochemical biosensor for 2,4,6-trichlorophenol.
    Nanotechnology 2018 Feb;29(7):074003
    School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, People's Republic of China. State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, People's Republic of China.
    Hemin immobilized into copper-based metal-organic frameworks was successfully prepared and used as a new electrode material for sensitive electrochemical biosensing. X-ray diffraction patterns, Fourier transform infrared spectra, scanning electron microscopy, UV-vis absorption spectroscopy, and cyclic voltammetry were used to characterize the resultant composites. Due to the interaction between the copper atom groups and hemin, the constrained environment in Cu-MOF-74 acts as a matrix to avoid the dimerization of enzyme molecules and retain its biological activity. Read More

    Trifluoroacetic acid: Three times the fluoride, three times the toxicity?
    Am J Emerg Med 2017 Dec 12. Epub 2017 Dec 12.
    Division of Medical Toxicology, University of California San Diego, San Diego, CA 92103, USA; Department of Emergency Medicine, University of California San Diego, San Diego, CA 92103, USA.
    Trifluoroacetic acid (TFAA) is a carboxylic acid, similar to acetic acid, used industrially and in laboratories. There is a paucity of data regarding exposure and the concern is that toxicity may mimic that of hydrofluoric acid (HF), causing electrolyte abnormalities, dysrhythmia, and cardiac arrest. We report a case of a 27-year-old male that presents with a dermal exposure to TFAA. Read More

    Caveolin-1 promotes the tumor suppressor properties of oncogene-induced cellular senescence.
    J Biol Chem 2018 Feb 15;293(5):1794-1809. Epub 2017 Dec 15.
    From the Department of Pharmacology and Chemical Biology,
    Oncogene-induced senescence (OIS) is considered a powerful tumor suppressor mechanism. Caveolin-1 acts as a scaffolding protein to functionally regulate signaling molecules. We demonstrate that a lack of caveolin-1 expression inhibits oncogenic K-Ras (K-Ras)-induced premature senescence in mouse embryonic fibroblasts and normal human bronchial epithelial cells. Read More

    Pharmaceutical aspects of silver nanoparticles.
    Artif Cells Nanomed Biotechnol 2017 Dec 12:1-12. Epub 2017 Dec 12.
    a Department of Pharmaceutics, School of Pharmaceutical Sciences , Rajiv Gandhi Technical University , Bhopal , India.
    Silver nanoparticles are particles in the size ranging between 1 and 100 nm. The two major methods used for synthesis of silver nanoparticle are the physical and chemical methods with the disadvantage that they are expensive and can also have toxicity. Biological method is being used as an expedient alternative, as this approach is environment-friendly and less toxic and it includes plant extracts, microorganism, fungi, etc. Read More

    Decellularised conjunctiva for ocular surface reconstruction.
    Acta Biomater 2018 Feb 8;67:259-269. Epub 2017 Dec 8.
    Department of Ophthalmology, University Hospital Duesseldorf, Heinrich-Heine-University, Germany. Electronic address:
    Conjunctival reconstruction is an integral component of ocular surface restoration. Decellularised tissues are frequently used clinically for tissue engineering. This study identifies porcine decellularised conjunctiva (PDC) and human decellularised conjunctiva (HDC) as promising substitutes for conjunctival reconstruction. Read More

    Dysphagia and feeding difficulties post-pediatric ingestion injury: Perspectives of the primary caregiver.
    Int J Pediatr Otorhinolaryngol 2017 Dec 14;103:20-28. Epub 2017 Sep 14.
    Lady Cilento Children's Hospital, 501 Stanley St, South Brisbane, QLD 4101 Australia.
    Purpose: To explore the experiences of children with dysphagia and/or feeding difficulties post-chemical or button battery ingestion injury from the perspective of the primary caregiver.

    Method: Five primary caregivers of children with a history of dysphagia and/or feeding difficulties post-ingestion injury (4 chemical, 1 button battery) completed the Children's Picky Eating Questionnaire (CPEQ), and participated in a semi-structured interview. Interviews explored experiences of caring for a child with dysphagia and/or feeding difficulties, impressions of services and supports, and additional impacts to the child and family. Read More

    Altered Neuroendocrine Immune Responses, a Two-Sword Weapon against Traumatic Inflammation.
    Int J Biol Sci 2017 1;13(11):1409-1419. Epub 2017 Nov 1.
    State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.
    During the occurrence and development of injury (trauma, hemorrhagic shock, ischemia and hypoxia), the neuroendocrine and immune system act as a prominent navigation leader and possess an inter-system crosstalk between the reciprocal information dissemination. The fundamental reason that neuroendocrinology and immunology could mix each other and permeate toward the field of traumatology is owing to their same biological languages or chemical information molecules (hormones, neurotransmitters, neuropeptides, cytokines and their corresponding receptors) shared by the neuroendocrine and immune systems. The immune system is not only modulated by the neuroendocrine system, but also can modulate the biological functions of the neuroendocrine system. Read More

    Urinary Phthalate Concentrations in Mothers and Their Children in Ireland: Results of the DEMOCOPHES Human Biomonitoring Study.
    Int J Environ Res Public Health 2017 Nov 25;14(12). Epub 2017 Nov 25.
    Federal Public Service Health, Food Chain Safety and Environment, Brussels 1060, Belgium.
    : Phthalates are chemicals which are widespread in the environment. Although the impacts on health of such exposure are unclear, there is evidence of a possible impact on the incidence of a diverse range of diseases. Monitoring of human exposure to phthalates is therefore important. Read More

    Chlorhexidine-Induced Chemical Burns in Very Low Birth Weight Infants.
    J Pediatr 2017 Dec;191:262-265.e2
    Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy.
    Skin disinfection with chlorhexidine gluconate has not been standardized in preterm infants. We present 5 cases of chemical burns that occurred within the first 2 days of life in very low birth weight neonates after skin disinfection with aqueous and alcohol-based chlorhexidine solutions. Read More

    Limbal Stem Cell Transplantation and Complications.
    Semin Ophthalmol 2018 27;33(1):134-141. Epub 2017 Nov 27.
    a Massachusetts Eye and Ear, Department of Ophthalmology , Harvard Medical School , Boston , MA , USA.
    Corneal epithelial stem cells are adult somatic stem cells located at the limbus and represent the ultimate source of transparent corneal epithelium. When these limbal stem cells become dysfunctional or deficient, limbal stem cell deficiency (LSCD) develops. LSCD is a major cause of corneal scarring and is particularly prevalent in chemical and thermal burns of the ocular surface. Read More

    Wnt/β-catenin pathway activation mediates adaptive resistance to BRAF inhibition in colorectal cancer.
    Mol Cancer Ther 2017 Nov 22. Epub 2017 Nov 22.
    Parmacology and Chemical Biology, University of Pittsburgh Cancer Institute
    One of the most encouraging developments in oncology has been the success of BRAF inhibitors in BRAF-mutant melanoma. However, in contrast to its striking efficacy in BRAF-mutant melanomas, BRAF inhibitor monotherapy is ineffective in BRAF-mutant colorectal cancer (CRC). While many studies on BRAF inhibitor resistance in CRC have focused on mechanisms underlying the reactivation of the EGFR/RAS/RAF/MEK/ERK pathway, the current study focuses on identifying novel adaptive signaling mechanisms, a fresh angle on CRC resistance to BRAF inhibition. Read More

    Chemical Burns Following Massage With Chopped Pulsatilla koreana.
    Wounds 2017 Nov;29(11):352-354
    Department of Plastic and Reconstructive Surgery, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea.
    Herbal massage is commonly used for cosmetic and antirheumatic purposes in the Republic of Korea. Cutaneous burns can complicate herbal massages, but this is a very rare occurrence. Pulsatilla koreana, the Korean pasque flower, is a species of the genus Pulsatilla from the Ranunculaceae family. Read More

    Comparative study of buffered 50% glycolic acid (pH 3.0) + 0.5% salicylic acid solution vs Jessner's solution in patients with acne vulgaris.
    J Cosmet Dermatol 2017 Nov 21. Epub 2017 Nov 21.
    Department of Dermatology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
    Background: Superficial chemical peels are frequently used in acne vulgaris treatment. Although glycolic acid (GA) has been widely used in clinical practice, its pH ranges from 0.08-2. Read More

    Critical and systematic evaluation of data for estimating human exposures to 2,4-dichlorophenoxyacetic acid (2,4-D) - quality and generalizability.
    J Toxicol Environ Health B Crit Rev 2017 20;20(8):423-446. Epub 2017 Nov 20.
    e Department of Anthropology , Alma College , Alma , MI , USA.
    The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) has been commercially available since the 1940's. Despite decades of data on 2,4-D in food, air, soil, and water, as well as in humans, the quality the quality of these data has not been comprehensively evaluated. Using selected elements of the Biomonitoring, Environmental Epidemiology, and Short-lived Chemicals (BEES-C) instrument (temporal variability, avoidance of sample contamination, analyte stability, and urinary methods of matrix adjustment), the quality of 156 publications of environmental- and biomonitoring-based 2,4-D data was examined. Read More

    Work environment and occupational risk assessment for small animal Portuguese veterinary activities.
    J Occup Environ Hyg 2017 Nov 20. Epub 2017 Nov 20.
    a Instituto Universitário da Maia, CIDESD-ISMAI , Castêlo da Maia , Portugal.
    The professional work of small animal veterinary staff encompasses a wide diversity of demanding tasks. This has prompted a number of studies covering physical, chemical, biological, ergonomic or psychological hazards, as well as their health effects upon veterinary workers. However, such results were obtained from self-reported surveys (via paper or online). Read More

    Classification of consumer products under the EU CLP Regulation: what to consider when caring for contact dermatitis patients.
    Contact Dermatitis 2018 Jan 17;78(1):1-6. Epub 2017 Nov 17.
    Department of Dermatology, University Hospital Jena, 07743, Jena, Germany.
    Possibly hazardous chemical substances and mixtures need to be clearly and correctly classified and labelled, in order for their hazards to be properly identified and communicated. As dermatologists may encounter cases of harm to patients induced by chemicals, such as chemical burns, and irritant and allergic contact dermatitis, it is essential for them to be aware of the EU CLP Regulation and its potential pitfalls. Manufacturers are required by CLP to classify their products according to the rules given in the CLP Regulation. Read More

    Keratolimbal allograft for limbal stem cell deficiency after severe corneal chemical injury: a systematic review.
    Br J Ophthalmol 2017 Nov 15. Epub 2017 Nov 15.
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.
    Purpose: To review the published literature on outcomes of keratolimbal allograft (KLAL) for the surgical treatment of limbal stem cell deficiency (LSCD) and corneal blindness after severe corneal chemical injury.

    Methods: Literature searches were conducted in the following electronic databases: MEDLINE, EMBASE, Science Citation Index, CINAHL, LILACS and the Cochrane Library. Standard systematic review methodology was applied. Read More

    Chemical Burns of the Eye: The Role of Retinal Injury and New Therapeutic Possibilities.
    Cornea 2018 Feb;37(2):248-251
    Cornea Service and Boston Keratoprosthesis Laboratory, Massachusetts Eye and Ear Infirmary and Schepens Eye Research Institute, Harvard Medical School, Boston, MA.
    Purpose: To propose a new treatment paradigm for chemical burns to the eye - in the acute and chronic phases.

    Methods: Recent laboratory and clinical data on the biology and treatment of chemical burns are analyzed.

    Results: Corneal blindness from chemical burns can now be successfully treated with a keratoprosthesis, on immediate and intermediate bases. Read More

    The inhibitory effect of different concentrations of KH902 eye drops on corneal neovascularization induced by alkali burn.
    Indian J Ophthalmol 2017 Nov;65(11):1127-1132
    Department of Ophthalmology, Jinling Medical School of Nanjing Medical University; Department of Ophthalmology, Jinling Hospital, Nanjing 210002, Jiangsu Province, PR China.
    Purpose: The aim of this study was to evaluate the inhibitory effect of different concentrations of KH902 eye drops on rabbit corneal neovascularization (CNV) induced by alkali burn.

    Methods: Forty-eight adult rabbits were randomized into four groups after alkali burning: Group A (2.5 mg/ml), Group B (5 mg/ml), and Group C (10 mg/ml) by different concentrations of KH902 eye drops and Group D by saline solution as control with three times a day for 2 weeks. Read More

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