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    Rapid production of human liver scaffolds for functional tissue engineering by high shear stress oscillation-decellularization.
    Sci Rep 2017 Jul 17;7(1):5534. Epub 2017 Jul 17.
    UCL Institute for Liver and Digestive Health, Royal Free Hospital. University College London, London, UK.
    The development of human liver scaffolds retaining their 3-dimensional structure and extra-cellular matrix (ECM) composition is essential for the advancement of liver tissue engineering. We report the design and validation of a new methodology for the rapid and accurate production of human acellular liver tissue cubes (ALTCs) using normal liver tissue unsuitable for transplantation. The application of high shear stress is a key methodological determinant accelerating the process of tissue decellularization while maintaining ECM protein composition, 3D-architecture and physico-chemical properties of the native tissue. Read More

    Retinoic Acid Engineered Amniotic Membrane Used as Graft or Homogenate: Positive Effects on Corneal Alkali Burns.
    Invest Ophthalmol Vis Sci 2017 Jul;58(9):3513-3518
    Translational Approach to Epithelial Injury and Repair Team, Université Clermont Auvergne, Centre National de Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Génétique Reproduction et Développement, Clermont-Ferrand, France.
    Purpose: Alkali burns are the most common, severe chemical ocular injuries, their functional prognosis depending on corneal wound healing efficiency. The purpose of our study was to compare the benefits of amniotic membrane (AM) grafts and homogenates for wound healing in the presence or absence of previous all-trans retinoic acid (atRA) treatment.

    Methods: Fifty male CD1 mice with reproducible corneal chemical burn were divided into five groups, as follows: group 1 was treated with saline solution; groups 2 and 3 received untreated AM grafts or grafts treated with atRA, respectively; and groups 4 and 5 received untreated AM homogenates or homogenates treated with atRA, respectively. Read More

    Egg Albumen as a Fast and Strong Medical Adhesive Glue.
    Adv Healthc Mater 2017 Jul 17. Epub 2017 Jul 17.
    Institute Burn Research, State Key Lab of Trauma, Burns and Combined Injury, Southwest Hospital and Third Military Medical University, Chongqing, 400038, China.
    Sutures penetrate tissues to close wounds. This process leads to inflammatory responses, prolongs healing time, and increases operation complexity. It becomes even worse when sutures are applied to stress-sensitive and fragile tissues. Read More

    The response of soil and stream chemistry to decreases in acid deposition in the Catskill Mountains, New York, USA.
    Environ Pollut 2017 Jul 6;229:607-620. Epub 2017 Jul 6.
    U.S. Geological Survey, New York Water Science Center, 425 Jordan Rd., Troy, NY 12180, United States.
    The Catskill Mountains have been adversely impacted by decades of acid deposition, however, since the early 1990s, levels have decreased sharply as a result of decreases in emissions of sulfur dioxide and nitrogen oxides. This study examines trends in acid deposition, stream-water chemistry, and soil chemistry in the southeastern Catskill Mountains. We measured significant reductions in acid deposition and improvement in stream-water quality in 5 streams included in this study from 1992 to 2014. Read More

    Transplanted adipose-derived stem cells can be short-lived yet accelerate healing of acid-burn skin wounds: a multimodal imaging study.
    Sci Rep 2017 Jul 5;7(1):4644. Epub 2017 Jul 5.
    Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, the Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
    The incidence of accidental and intentional acid skin burns is rising. Current treatment strategies are mostly inadequate, leaving victims disfigured and without treatment options. Here, we have shown that transplantation of adipose-derived stem cells (ASCs) accelerates the process of acid burn wound-healing. Read More

    Selective Localized Tenonplasty for Corneal Burns Based on the Findings of Ocular Surface Fluorescein Angiography.
    Cornea 2017 Aug;36(8):1014-1017
    Ocular Trauma and Emergency Unit, Eye Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
    Purpose: To report the results of a selective localized tenonplasty procedure based on findings of ocular surface fluorescein angiography (FA).

    Methods: Six consecutive patients with severe chemical burns were included in this study. Using fluorescein angiogram images, patients underwent selective localized tenonplasty to cover the identified ischemic areas in FA. Read More

    Quality Control of the Root and Rhizome of Helminthostachys zeylanica (Daodi-Ugon) by HPLC Using Quercetin and Ugonins as Markers.
    Molecules 2017 Jul 5;22(7). Epub 2017 Jul 5.
    Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.
    Daodi-Ugon is the dried root and rhizome of Helminthostachys zeylanica (L.) Hook. and has been used for centuries in the treatment of inflammation, fever, pneumonia, burns, and various disorders. Read More

    Advances in keratinocyte delivery in burn wound care.
    Adv Drug Deliv Rev 2017 Jun 28. Epub 2017 Jun 28.
    School of Chemical Engineering, University of Birmingham, Edgbaston B15 2TT, United Kingdom. Electronic address:
    This review gives an updated overview on keratinocyte transplantation in burn wounds concentrating on application methods and future therapeutic cell delivery options with a special interest in hydrogels and spray devices for cell delivery. To achieve faster re-epithelialisation of burn wounds, the original autologous keratinocyte culture and transplantation technique was introduced over 3 decades ago. Application types of keratinocytes transplantation have improved from cell sheets to single-cell solutions delivered with a spray system. Read More

    Upper Gastrointestinal Endoscopic Evaluation Following Household Sodium Hypochlorite Ingestion.
    J Burn Care Res 2017 Jun 28. Epub 2017 Jun 28.
    From the *Department of Internal Medicine, Loghman-Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran; †University Department of Surgery, Royal Perth Hospital, Perth, Australia; ‡Toxicological Research Center, Department of Clinical Toxicology, Loghman-Hakim Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; and §Excellence Center of Clinical Toxicology, Ministry of Health, Tehran, Iran.
    Endoscopy is generally speculated to be unnecessary in sodium hypochlorite (NaClO) ingestions; however, a significant number of endoscopic evaluations are still being performed when this chemical is ingested. Therefore, the aim of the current study was to compare the outcome and endoscopic findings between patients who had ingested household NaClO and those who had ingested other types of corrosives. This retrospective cohort study enrolled 137 patients with a history of corrosive substance ingestion admitted to a tertiary hospital. Read More

    Varying and unchanging whiteness on the wings of dusk-active and shade-inhabiting Carystoides escalantei butterflies.
    Proc Natl Acad Sci U S A 2017 Jul 26;114(28):7379-7384. Epub 2017 Jun 26.
    Department of Materials Science and Engineering, University of Pennsylvania, Philadelphia, PA 19104;
    Whiteness, although frequently apparent on the wings, legs, antennae, or bodies of many species of moths and butterflies, along with other colors and shades, has often escaped our attention. Here, we investigate the nanostructure and microstructure of white spots on the wings of Carystoides escalantei, a dusk-active and shade-inhabiting Costa Rican rain forest butterfly (Hesperiidae). On both males and females, two types of whiteness occur: angle dependent (dull or bright) and angle independent, which differ in the microstructure, orientation, and associated properties of their scales. Read More

    Agents, mechanisms and clinical features of non-scald burns in children: A prospective UK study.
    Burns 2017 Jun 20. Epub 2017 Jun 20.
    Institute of Primary Care & Public Health, Cardiff University School of Medicine, Neuadd Meirionnydd, Heath Park, Cardiff, UK. Electronic address:
    Aims: To inform childhood burn prevention by identifying demographics, clinical features and circumstances of unintentional non-scald burns.

    Methods: A prospective cross-sectional study was conducted across Cardiff, Bristol and Manchester, including six emergency departments, three minor injury units and one burns unit between 13/01/2013-01/10/2015. Data collected for children aged <16 years with any burn (scald, contact, flame, radiation, chemical, electrical, friction) included: demographics, circumstances of injury and clinical features. Read More

    Skin-Inspired Multifunctional Autonomic-Intrinsic Conductive Self-Healing Hydrogels with Pressure Sensitivity, Stretchability, and 3D Printability.
    Adv Mater 2017 Jun 22. Epub 2017 Jun 22.
    Institute of Burn Research; State Key Lab of Trauma Burns and Combined Injury, Southwest Hospital, Third Millitary Medical University, Chongqing, 400038, China.
    The advent of conductive self-healing (CSH) hydrogels, a class of novel materials mimicking human skin, may change the trajectory of the industrial process because of their potential applications in soft robots, biomimetic prostheses, and health-monitoring systems. Here, the development of a mechanically and electrically self-healing hydrogel based on physically and chemically cross-linked networks is reported. The autonomous intrinsic self-healing of the hydrogel is attained through dynamic ionic interactions between carboxylic groups of poly(acrylic acid) and ferric ions. Read More

    Prevalence, subtypes, severity and determinants of ocular trauma: The Singapore Chinese Eye Study.
    Br J Ophthalmol 2017 Jun 16. Epub 2017 Jun 16.
    Health Services Research, Singapore Eye Research Institute, Singapore, Singapore.
    Purpose: To describe the prevalence, subtypes, severity and determinants of ocular trauma (OT) in a population-based study in Singapore.

    Methods: We included 3353 Chinese adults aged ≥40 years from the Singapore Chinese Eye Study, a population-based study, conducted between 2009 and 2011. OT was defined as self-reported history of any eye injury requiring medical attention with or without hospitalisation, and further classified as blunt object, sharp object or chemical burns related. Read More

    Analysis of fire deaths in Poland and influence of smoke toxicity.
    Forensic Sci Int 2017 Aug 9;277:77-87. Epub 2017 Jun 9.
    Centre for Fire Hazards and Science, School of Physical Sciences and Computing, University of Central Lancashire, Preston PR1 2HE, UK. Electronic address:
    Dwelling fires have changed over the years because building contents and the materials used in then have changed. They all contribute to an ever-growing diversity of chemical species found in fires, many of them highly toxic. These arise largely from the changing nature of materials in interior finishes and furniture, with an increasing content of synthetic materials containing higher levels of nitrogen, halogen and phosphorus additives. Read More

    Cisplatin Increases Sensitivity to FGFR Inhibition in Patient-Derived Xenograft Models of Lung Squamous Cell Carcinoma.
    Mol Cancer Ther 2017 Jun 13. Epub 2017 Jun 13.
    ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
    Lung squamous cell carcinoma (SqCC) is a molecularly complex and genomically unstable disease. No targeted therapy is currently approved for lung SqCC, although potential oncogenic drivers of SqCC have been identified, including amplification of the fibroblast growth factor receptor 1 (FGFR1). Reports from a recently completed clinical trial indicate low response rates in patients treated with FGFR tyrosine kinase inhibitors, suggesting inadequacy of FGFR1 amplification as a biomarker of response, or the need for combination treatment. Read More

    [Keratoplasty classification and primary disease spectrum analysis of 315 cases].
    Zhonghua Yan Ke Za Zhi 2017 Jun;53(6):460-463
    Department of Ophthalmology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
    Objective: To identify the primary disease spectrum and trends of surgical procedure of keratoplasty patients. Methods: Retrospective case series study. To review all patients who underwent keratoplasty at Department of ophthalmology in Tongji Hospital from January 1, 2012 to December 31, 2015. Read More

    In Vivo Assessment of Engineered Skin Cell Delivery with Multimodal Optical Microscopy.
    Tissue Eng Part C Methods 2017 Jul;23(7):434-442
    1 Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign , Urbana, Illinois.
    The healing process is often significantly impaired under conditions of chronic or large area wounds, which are often treated clinically using autologous split-thickness skin grafts. However, in many cases, harvesting of donor tissue presents a serious problem such as in the case of very large area burns. In response to this, engineered biomaterials have emerged that attempt to mimic the natural skin environment or deliver a suitable therapy to assist in the healing process. Read More

    Discovery of Two Bacterial Nitric Oxide-Responsive Proteins and Their Roles in Bacterial Biofilm Regulation.
    Acc Chem Res 2017 Jul 12;50(7):1633-1639. Epub 2017 Jun 12.
    Graduate Program in Biochemistry and Structural Biology, Stony Brook University , Stony Brook, New York 11794-5215, United States.
    Bacterial biofilms form when bacteria adhere to a surface and produce an exopolysaccharide matrix ( Costerton Science 1999 , 284 , 1318 ; Davies Science 1998 , 280 , 295 ; Flemming Nat. Rev. Microbiol. Read More

    Particle Size Influences on the Coating Microstructure through Green Chromia Inclusion in Plasma Electrolytic Oxidation.
    ACS Appl Mater Interfaces 2017 Jul 22;9(26):21864-21871. Epub 2017 Jun 22.
    Department of Mechanical Engineering, National Taiwan University of Science and Technology , 43, Keelung Road, Section 4, Taipei 10607 Taiwan.
    In an effort to color the aluminum alloy surface green via plasma electrolytic oxidation (PEO), two alkaline solutions have been employed with particulate inclusions and sodium aluminate. Electrolyte I comprises a self-made chromia pigment with a mean particle size 69 nm, whereas electrolyte II contains a commercially available pigment, GN-M, with a larger particle size 351 nm. Both pigments are oxygen deficient Cr2O3-δ of corundum-type structure before coating, the oxidative environment of PEO converts them into stoichiometric Cr2O3. Read More

    Ann Burns Fire Disasters 2017 Mar;30(1):18-23
    Réanimation Chirurgicale et des Brûlés, PTMC, CHU Nantes, 44093 Nantes CEDEX, France.
    Cement burn is a common cause of chemical burns in France. They usually need surgical treatment. This retrospective study was performed among 49 patients, aged 21-71 years, admitted to the St Joseph-St Luc Hospital in Lyon, France. Read More

    Pattern and profile of electric burn injury cases at a Burn centre.
    J Ayub Med Coll Abbottabad 2016 Oct-Dec;28(4):702-705
    Department of Plastic & Reconstructive Surgery, Punjab Medical College/ Allied Hospital, Faisalabad, Pakistan.
    Background: Electrical burns are quite different from thermal and chemical burns. This study is from a centre which deals with job related electric burn injuries alone and thus can give a pure account of the electric burns and discuss the related peculiarities. Study aims to highlight the differences in the mechanism of electric burn injury, its mode of presentation, morbidity, complications and thus the treatment strategies as compared to rest of the burn injuries. Read More

    A search for new phenomena in pp collisions at [Formula: see text] in final states with missing transverse momentum and at least one jet using the [Formula: see text] variable.
    Eur Phys J C Part Fields 2017 8;77(5):294. Epub 2017 May 8.
    University of Wisconsin-Madison, Madison, WI USA.
    A search for new phenomena is performed in final states containing one or more jets and an imbalance in transverse momentum in pp collisions at a centre-of-mass energy of 13[Formula: see text]. The analysed data sample, recorded with the CMS detector at the CERN LHC, corresponds to an integrated luminosity of 2.3[Formula: see text]. Read More

    Venous Thromboembolism in Patients with Thermal Injury: A Review of Risk Assessment Tools and Current Knowledge on the Effectiveness and Risks of Mechanical and Chemical Prophylaxis.
    Clin Plast Surg 2017 Jul;44(3):573-581
    Department of Surgery, University of Utah Burn Center, University of Utah, 30 North 1900 East 3B400, Salt Lake City, UT 84132, USA.
    Venous thromboembolism (VTE) can be a life-threatening or limb-threatening complication of thermal injury. The severity of burn injury can be used to predict VTE risk among patients with thermal injury, and a weighted risk-stratification tool has been developed. This article reviews the incidence, diagnosis, and management of thromboembolic events in patients with burns. Read More

    Patient With Scald Burn of the Esophagus.
    J Burn Care Res 2017 May 26. Epub 2017 May 26.
    From the *Department of Cardiac, Thoracic and Vascular Surgery, University of Ulm, Germany; †Department of Surgery, Klinikum Memmingen, Memmingen, Academic Teaching Hospital of the Ludwig-Maximilians-University, Munich, Germany; and ‡Department of Surgery, Ross Tilley Burn Centre, Sunnybrook Health Science Centre and University of Toronto, Ontario, Canada.
    Burns of the esophagus are usually caused by chemical substances. In our report, we present a case of burn injury burn caused by swallowing boiling water under the influence of controlled substances. During the initial diagnostic procedures, a CT scan was performed. Read More

    'Printability' of Candidate Biomaterials for Extrusion Based 3D Printing: State-of-the-Art.
    Adv Healthc Mater 2017 May 30. Epub 2017 May 30.
    Reconstructive Surgery & Regenerative Medicine Group (ReconRegen), Institute of Life Sciences, Swansea University Medical School, Swansea, SA2 8PP, UK.
    Regenerative medicine has been highlighted as one of the UK's 8 'Great Technologies' with the potential to revolutionize patient care in the 21st Century. Over the last decade, the concept of '3D bioprinting' has emerged, which allows the precise deposition of cell laden bioinks with the aim of engineering complex, functional tissues. For 3D printing to be used clinically, there is the need to produce advanced functional biomaterials, a new generation of bioinks with suitable cell culture and high shape/print fidelity, to match or exceed the physical, chemical and biological properties of human tissue. Read More

    Tissue engineered skin and wound healing: current strategies and future directions.
    Curr Pharm Des 2017 May 25. Epub 2017 May 25.
    Biomaterials and Tissue Engineering Laboratory, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati-781039. India.
    The global volume of skin damage or injuries has major healthcare implications and, accounts for about half of the world's annual expenditure in the healthcare sector. In the last two decades, tissue-engineered skin constructs have shown great promise in the treatment of various skin-related disorders such as deep burns and wounds. The treatment methods for skin replacement and repair have evolved from utilization of autologous epidermal sheets to more complex bilayered cutaneous tissue engineered skin substitutes. Read More

    Fabrication of a Biodegradable Implant with Tunable Characteristics for Bone Implant Applications.
    Biomacromolecules 2017 Jun 23;18(6):1736-1746. Epub 2017 May 23.
    The University of Sydney , School of Chemical and Biomolecular Engineering, Sydney, 2006, Australia.
    Biodegradable polymers are appealing material for the manufacturing of surgical implants as such implants break down in vivo, negating the need for a subsequent operation for removal. Many biocompatible polymers produce acidic breakdown products that can lead to localized inflammation and osteolysis. This study assesses the feasibility of fabricating implants out of poly(propylene carbonate) (PPC)-starch that degrades into CO2 and water. Read More

    Measurement of prompt and nonprompt [Formula: see text] production in [Formula: see text] and [Formula: see text] collisions at [Formula: see text].
    Eur Phys J C Part Fields 2017 27;77(4):269. Epub 2017 Apr 27.
    University of Wisconsin-Madison, Madison, WI USA.
    This paper reports the measurement of [Formula: see text] meson production in proton-proton ([Formula: see text]) and proton-lead ([Formula: see text]) collisions at a center-of-mass energy per nucleon pair of [Formula: see text] by the CMS experiment at the LHC. The data samples used in the analysis correspond to integrated luminosities of 28[Formula: see text] and 35[Formula: see text] for [Formula: see text] and [Formula: see text] collisions, respectively. Prompt and nonprompt [Formula: see text] mesons, the latter produced in the decay of [Formula: see text] hadrons, are measured in their dimuon decay channels. Read More

    Suppression and azimuthal anisotropy of prompt and nonprompt [Formula: see text] production in PbPb collisions at [Formula: see text][Formula: see text].
    Eur Phys J C Part Fields 2017 19;77(4):252. Epub 2017 Apr 19.
    University of Wisconsin-Madison, Madison, WI USA.
    The nuclear modification factor [Formula: see text] and the azimuthal anisotropy coefficient [Formula: see text] of prompt and nonprompt (i.e. those from decays of b hadrons) [Formula: see text] mesons, measured from PbPb and pp collisions at [Formula: see text] [Formula: see text] at the LHC, are reported. Read More

    Measurement of the WZ production cross section in pp collisions at [Formula: see text] and 8[Formula: see text] and search for anomalous triple gauge couplings at [Formula: see text].
    Eur Phys J C Part Fields 2017 12;77(4):236. Epub 2017 Apr 12.
    University of Wisconsin-Madison, Madison, WI USA.
    The WZ production cross section is measured by the CMS experiment at the CERN LHC in proton-proton collision data samples corresponding to integrated luminosities of 4.9[Formula: see text] collected at [Formula: see text], and 19.6[Formula: see text] at [Formula: see text]. Read More

    Fatal Ingestion of Chlumsky Disinfectant Solution.
    J Forensic Sci 2017 May 16. Epub 2017 May 16.
    Department of Anatomy, Faculty of Medicine, Masaryk University, CZ-625 00, Brno, Czech Republic.
    A 32-year-old pregnant woman in the 25th week of pregnancy underwent oral glucose tolerance screening at the diabetologist's. Later that day, she was found dead in her apartment possibly poisoned with Chlumsky disinfectant solution (solutio phenoli camphorata). An autopsy revealed chemical burns in the digestive system. Read More

    SABRE hyperpolarisation of vitamin B3 as a function of pH.
    Chem Sci 2017 Mar 7;8(3):2257-2266. Epub 2016 Dec 7.
    Centre for Hyperpolarisation in Magnetic Resonance , Department of Chemistry , University of York , YO10 5NY , York , UK . Email:
    In this work we describe how the signal enhancements obtained through the SABRE process in methanol-d4 solution are significantly affected by pH. Nicotinic acid (vitamin B3, NA) is used as the agent, and changing pH is shown to modify the level of polarisation transfer by over an order of magnitude, with significant improvements being seen in terms of the signal amplitude and relaxation rate at high pH values. These observations reveal that manipulating pH to improve SABRE enhancements levels may improve the potential of this method to quantify low concentrations of analytes in mixtures. Read More

    Antibacterial efficacy of poly(vinyl alcohol) composite nanofibers embedded with silver-anchored silica nanoparticles.
    J Biomed Mater Res B Appl Biomater 2017 May 15. Epub 2017 May 15.
    Nano Fusion Technology Research Lab, Division of Frontier Fibers, Institute for Fiber Engineering (IFES), Interdisciplinary Cluster for Cutting Edge Research (ICCER), Shinshu University 3-15-1, Tokida, Ueda, Nagono, 386-8567, Japan.
    Silver has been widely used as an effective antibacterial agent especially for treating burns and wounds. However, release of silver from materials often arouse side effects due to toxicity of silver towards mammalian cells. Argyria and argyrosis are well known problems of acute toxicity of silver towards human body. Read More

    Caustic Ingestions and Foreign Bodies Ingestions in Pediatric Patients.
    Pediatr Clin North Am 2017 Jun;64(3):507-524
    Department of Pediatric Gastroenterology, Hepatology and Nutrition, Cleveland Clinic Foundation, 9500 Euclid Avenue, Dept A111, Cleveland, OH 44195-0001, USA.
    Children inevitably swallow foreign material accidentally or intentionally. Each type of ingestion carries their own set of risks and complications, short and long term, some requiring immediate attention while others close monitoring. Alkalotic household cleaning products and lithium button batteries are increasingly common and damage the esophagus quickly. Read More

    Psi4 1.1: An Open-Source Electronic Structure Program Emphasizing Automation, Advanced Libraries, and Interoperability.
    J Chem Theory Comput 2017 Jul 6;13(7):3185-3197. Epub 2017 Jun 6.
    Center for Computational Molecular Science and Technology, School of Chemistry and Biochemistry, School of Computational Science and Engineering, Georgia Institute of Technology , Atlanta, Georgia 30332-0400, United States.
    Psi4 is an ab initio electronic structure program providing methods such as Hartree-Fock, density functional theory, configuration interaction, and coupled-cluster theory. The 1.1 release represents a major update meant to automate complex tasks, such as geometry optimization using complete-basis-set extrapolation or focal-point methods. Read More

    Relative Modification of Prompt ψ(2S) and J/ψ Yields from pp to PbPb Collisions at sqrt[s_{NN}]=5.02  TeV.