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    Determining the role of nasolaryngoscopy in the initial evaluation for upper airway injury in patients with facial burns.
    Burns 2017 Nov 6. Epub 2017 Nov 6.
    Department of Surgery, University of South Alabama School of Medicine, 2451 Fillingim Street, Mobile, AL, 36695, USA. Electronic address:
    Background: Upper airway injuries can be fatal in burn patients if not recognized, a scenario that causes a significant amount of anxiety for physicians providing initial assessment of burn patients. Early elective intubation is often performed; sometimes unnecessarily. However, some providers employ nasolaryngoscopy for patients presenting with facial burns or signs/symptoms of upper airway injury in order to assess the need for intubation, but this practice is not considered standard of care and may also be unnecessary. Read More

    Towards a reliable paradigm shift in emergency medical service for improving mass burn casualty response.
    Burns 2017 Nov 1. Epub 2017 Nov 1.
    Department and Graduate School of Safety and Environment Engineering, National Yunlin University of Science & Technology, 123, Section 3, University Road, Douliou, Yunlin 640, Taiwan, ROC; Research Center for Soil & Water Resources and Natural Disaster Prevention (SWAN), National Yunlin University of Science & Technology, 123, Section 3, University Road, Douliou, Yunlin 640, Taiwan, ROC. Electronic address:

    Accelerant-related burns and drug abuse: Challenging combination.
    Burns 2017 Oct 31. Epub 2017 Oct 31.
    Division of Plastic & Reconstructive Surgery, University of British Columbia, Vancouver, B.C., Canada.
    Background: Accelerants are flammable substances that may cause explosion when added to existing fires. The relationships between drug abuse and accelerant-related burns are not well elucidated in the literature. Of these burns, a portion is related to drug manufacturing, which have been shown to be associated with increased burn complications. Read More

    Characterization of variables for potential impact on vancomycin pharmacokinetics in thermal or inhalation injury.
    Burns 2017 Oct 30. Epub 2017 Oct 30.
    Medical Director, Department of Plastic Surgery, Firefighters Regional Burn Center, Regional One Health, 877 Jefferson Avenue, Memphis, TN 38103, USA; Professor, Department of Plastic Surgery, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38103, USA. Electronic address:
    Objective: To characterize the pharmacokinetics of vancomycin dosing in thermal or inhalation injury as they relate to percent total body surface area burn (TBSA) and days since injury (DSI).

    Methods: This retrospective 3-year study included patients with thermal or inhalation injury receiving vancomycin. Patient demographics and course data were collected using the institution's electronic medical record. Read More

    Response to Letter to the Editor: 'Cardiovascular risk profile in burn survivors: Methodological issues'.
    Burns 2017 Oct 28. Epub 2017 Oct 28.
    Burns, Trauma and Critical Care Research Centre, School of Medicine, University of Queensland, Brisbane, Herston, 4029, Australia; School of Allied Health Sciences, Griffith University, Southport, Gold Coast, 4222, Australia. Electronic address:

    Up-regulation of α1-adrenoceptors in burn and keloid scars.
    Burns 2017 Oct 28. Epub 2017 Oct 28.
    Burn Injury Research Unit, School of Surgery, University of Western Australia, Australia; The Fiona Wood Foundation, Perth, Western Australia, Australia.
    Stimulation of α1-adrenoceptors evokes inflammatory cytokine production, boosts neurogenic inflammation and pain, and influences cellular migration and proliferation. Hence, these receptors may play a role both in normal and abnormal wound healing. To investigate this, the distribution of α1-adrenoceptors in skin biopsies of burn scars (N=17), keloid scars (N=12) and unscarred skin (N=17) was assessed using immunohistochemistry. Read More

    Burned patients who die from causes other than the burn affect the model used to predict mortality: A national exploratory study; Methodological issues.
    Burns 2017 Oct 28. Epub 2017 Oct 28.
    Managerial Epidemiology Research Center, Department of Public Health, School of Nursing and Midwifery, Maragheh University of Medical Sciences, Maragheh, Iran; Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

    Response to comments on: Burned patients who die from causes other than the burn affect the model used to predict mortality: A national exploratory study.
    Burns 2017 Oct 28. Epub 2017 Oct 28.
    Department of Plastic Surgery, Hand Surgery, and Burns, Linköping University, Linköping, Sweden; Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden; Department of Anaesthesiology and Intensive Care, Linköping University, Linköping, Sweden.

    Massage has no observable effect on distress in children with burns: A randomized, observer-blinded trial.
    Burns 2017 Oct 28. Epub 2017 Oct 28.
    Department of Pediatric Surgery, Red Cross War Memorial Children's Hospital, Cape Town, South Africa.
    Importance: In a previous observational study we found that massage therapy reduced anxiety and stress in pediatric burn patients. We aimed to test this effect in a randomized controlled trial.

    Objective: To determine whether (1) aromatherapy massage can provide relaxation to hospitalized children with burns; (2) massage with aromatherapy oil is more effective than without; and (3) massage sessions are more effective when repeated. Read More

    Pre-burn malnutrition increases operative mortality in burn patients who undergo early excision and grafting in a sub-Saharan African burn unit.
    Burns 2017 Oct 28. Epub 2017 Oct 28.
    Department of Surgery, University of North Carolina at Chapel Hill, United States; Kamuzu Central Hospital, Lilongwe, Malawi. Electronic address:
    Introduction: In the developed world, pre-existing malnutrition in the burn population influences operative outcomes. However, studies on pre-existing malnutrition and operative outcomes of burn patients in the developing world are lacking. We therefore sought to characterize the burn injury outcomes following operative intervention based on nutritional status. Read More

    Extension of flaps associated with burn scar reconstruction: A key difference between island and skin-pedicled flaps.
    Burns 2017 Oct 28. Epub 2017 Oct 28.
    Department of Plastic, Reconstructive, and Aesthetic Surgery, Nippon Medical School Hospital, Tokyo, Japan.
    Objective: The choice between local flap designs for burn reconstruction is largely shaped by aesthetic, vascularity, procedural complexity, and wound-closure considerations. However, another key consideration is how well specific local flap designs release post-burn scar contractures. This is because constant tension on wound edges can generate pathological scarring. Read More

    The impact of operative time and hypothermia in acute burn surgery.
    Burns 2017 Oct 28. Epub 2017 Oct 28.
    Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Toronto, Canada; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto, Canada.
    Background: Prolonged operative time and intraoperative hypothermia are known to have deleterious effects on surgical outcomes. Although millions of burn injuries undergo operative treatment globally every year, there remains a paucity of evidence to guide perioperative practice in burn surgery. This study evaluated associations between hypothermia and operative time on post-operative complications in acute burn surgery. Read More

    Clinical outcomes after burns in elderly patients over 70 years: A 17-year retrospective analysis.
    Burns 2017 Oct 20. Epub 2017 Oct 20.
    Department of Surgery, RWJ Barnabas Health, Livingston, NJ, USA; Saint George's University School of Medicine, Grenada.
    Introduction: In the United Stated population >70years is likely to double by the year 2050. Elderly population (>70years) are most vulnerable to burns and outcomes following such injuries in this special group is poorly studied. This study aimed to look at outcomes following burns in patients >70years over a period of 17 years. Read More

    Burns caused by electronic vaping devices (e-cigarettes): A new classification proposal based on mechanisms.
    Burns 2017 Oct 19. Epub 2017 Oct 19.
    Department of Plastic Reconstructive Surgery, Burn Center, Hôpital Saint Louis, AP-HP 1 Avenue Claude Vellefaux, 75010 Paris, France.
    Introduction With more than 10 million of daily users, e-cigarettes encountered a great success. But in the past few years, the number of medical reports of injuries caused by the explosion of e-cigarettes has significantly increased. This article aims at reporting our series and reviewing the literature to propose a new classification based on the mechanisms of injuries related to e-cigarettes that can guide non-specialists and specialists in the management of these patients. Read More

    Eschar removal by bromelain based enzymatic debridement (Nexobrid(®)) in burns: An European consensus.
    Burns 2017 Oct 12. Epub 2017 Oct 12.
    BG Trauma Center, Hand-, Plastic and Reconstructive Surgery, Burn Center, University of Heidelberg, Ludwigshafen, Germany.
    Early debridement and/or eschar removal is regarded as a significant step in the treatment of deep partial and full thickness burns. It aims to control wound bioburden and allows early wound closure by conservative treatment or skin grafting. Preservation of viable dermis accompanied by early wound closure, is regarded as a necessary step to reduce scar related complication, e. Read More

    Nationwide web survey of pediatric scalds: Prevalence and the relationship with household vacuum flasks.
    Burns 2017 Oct 9. Epub 2017 Oct 9.
    Department of Burns and Plastic Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, PR China. Electronic address:
    Objective: To explore the prevalence of pediatric (0-72 months old) scalds, and to clarify its relationship with household vacuum flasks.

    Methods: A cross sectional online survey based on the largest social media in China. Online questionnaire was pushed twice a day to our target respondents for successive seven days. Read More

    Management of finger deep burns: The interest of local flaps.
    Burns 2017 Oct 9. Epub 2017 Oct 9.
    Service de chirurgie plastique et reconstructrice - Centre des brûlés, Hôtel Dieu, CHU de Nantes, 44093 Nantes Cedex 01, France; Inserm UMR957, Laboratoire de physiopathologie de la résorption osseuse, Université de Nantes, 44035 Nantes, France.
    Introduction: The management of finger deep burns is still problematic for the surgeon. Due to the fineness and the thickness of the subcutaneous tissue, after excision there is an important risk of exposure of the underlying tissue like bone, nerve or tendons. Local flaps (random pattern flap and pedicle flap) allowed ensuring a good quality covering with a tissue with many advantages (good thickness, sensitivity). Read More

    A treatment algorithm for the management of intraoral burns: A narrative review.
    Burns 2017 Oct 9. Epub 2017 Oct 9.
    University of Pennsylvania School of Dental Medicine, Robert Schattner Center, Oral Surgery Clinic, 240 S. 40th Street, Philadelphia, PA 19104, United States; University of Pennsylvania Health System, Perelman Center for Advanced Medicine, South Pavilion, 4th Floor, 3400 Civic Center Boulevard, Philadelphia, PA 19104, United States; Philadelphia Veterans Affairs Medical Center, University of Pennsylvania Presbyterian Medical Center, 565 Wright Saunders, 51 N. 39th Street, Philadelphia, PA 19104, United States. Electronic address:
    Oral mucosa follows a distinctly different trajectory of wound healing than skin. Although there are contemporary guidelines regarding treatment of burns to the skin, there is no standard of care specific to intraoral burns. This narrative review proposes an evidence-based treatment algorithm for the management of intraoral burns. Read More

    Histological observation of hairless mice skin after exposure to Simulated Solar Light: Comparison between the histological findings with different methodologies and 3R principle correlations.
    Burns 2017 Oct 9. Epub 2017 Oct 9.
    Laboratório de Microbiologia e Avaliação Genotóxica, Departamento de Análises Clínicas e Toxicológicas, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
    Background: Albino hairless mouse (AHM) has been used as a biological model in photodermatology. However, the experimental landscape is diverse to follow and need particular attention.

    Purpose: Irradiation parameters were investigated for the development of a protocol to assess alterations in the AHM skin using Simulated Solar Light (SSL). Read More

    Analysis of factor XIa, factor IXa and tissue factor activity in burn patients.
    Burns 2017 Oct 9. Epub 2017 Oct 9.
    University of Vermont, Department of Biochemistry, Burlington, VT, United States. Electronic address:
    Introduction: An elevated procoagulant activity observed in trauma patients is, in part, related to tissue factor (TF) located on blood cells and microparticles. However, analysis of trauma patient plasma indicates that there are other contributor(s) to the procoagulant activity. We hypothesize that factor (F)XIa and FIXa are responsible for an additional procoagulant activity in burn patients. Read More

    The application of 3D-printed transparent facemask for facial scar management and its biomechanical rationale.
    Burns 2017 Oct 9. Epub 2017 Oct 9.
    Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China. Electronic address:
    Introduction: Deep facial burns leave conspicuous scar to the patients and affect their quality of life. Transparent facemask has been adopted for the prevention and treatment of facial hypertrophic scars for decades. Recently, with the advancement of 3D printing, the transparent facemask could facilitate the fitting of the facial contour. Read More

    Comparison of non-surgical methods for the treatment of deep partial thickness skin burns of the hand.
    Burns 2017 Oct 9. Epub 2017 Oct 9.
    Department of Thermal Injuries, Republican Vilnius University Hospital, Lithuania.
    This paper describes a randomized, controlled, parallel-group, single-center clinical trial designed to compare non surgical treatment methods of deep partial thickness skin burns of the hand. All patients were scanned with the Laser Doppler Imaging device to determine the depth of the burn wound. Viable keratinocytes sites were determined according to the established Perfusion Units (PU) measurement system. Read More

    Prospective comparative evaluation study of Laser Doppler Imaging and thermal imaging in the assessment of burn depth.
    Burns 2017 Oct 9. Epub 2017 Oct 9.
    Scar Free Foundation Centre for Burns Research, University Hospital Birmingham NHS Foundation Trust, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham B15 2WB, UK; University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. Electronic address:
    Introduction: The accurate assessment of burn depth is challenging but crucial for surgical excision and tissue preservation. Laser Doppler Imaging (LDI) has gained increasing acceptance as a tool to aid depth assessment but its adoption is hampered by high costs, long scan times and limited portability. Thermal imaging is touted as a suitable alternative however few comparison studies have been done. Read More

    Long term cardiovascular impacts after burn and non-burn trauma: A comparative population-based study.
    Burns 2017 Oct 9. Epub 2017 Oct 9.
    Burn Injury Research Unit, University of Western Australia, Western Australia, Australia; Burns Service of Western Australia, Fiona Stanley Hospital and Princess Margaret Hospital, Western Australia, Australia.
    Objective: To compare post-injury cardiovascular disease (CVD) hospital admissions experienced by burn patients with non-burn trauma patients and people with no record of injury, adjusting for socio-demographic, health and injury factors.

    Methods: Linked hospital and death data were analysed for a cohort of burn patients (n=30,997) hospitalised in Western Australia during the period 1980-2012 and age and gender frequency matched comparison cohorts (non-burn trauma: n=28,647; non-injured: n=123,399). The number and length of hospital stay for CVD admissions were used as outcome measures. Read More

    Platelet count: A predictor of sepsis and mortality in severe burns.
    Burns 2017 Oct 9. Epub 2017 Oct 9.
    The Scar Free Foundation Birmingham Centre for Burns Research, Birmingham, UK; NIHR Surgical Reconstruction and Microbiology Research Centre, University Hospitals Birmingham NHS Foundation Trust, UK; Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust, Mindelsohn Way, Birmingham B15 2WB, UK. Electronic address:
    Background: Platelet cells, or thrombocytes, have additional roles to haemostasis. After burn injury, platelet counts drop to a nadir at days 2-5 then rise to a peak between days 10-18. The nadir has previously been associated with mortality but there is currently no thorough investigation of its potential to predict sepsis in adults. Read More

    The effect of adipose derived stromal vascular fraction on stasis zone in an experimental burn model.
    Burns 2017 Oct 9. Epub 2017 Oct 9.
    Baskent University Faculty of Medicine, Department of General Surgery, Ankara, Turkey.
    Background: Stasis zone is the surrounding area of the coagulation zone which is an important part determining the extent of the necrosis in burn patients. In our study we aim to salvage the stasis zone by injecting adipose derived stromal vascular fraction (ADSVF).

    Methods: Thermal injury was applied on dorsum of Sprague-Dawley rats (n=20) by the "comb burn" model as described previously. Read More

    Early intervention by Captopril does not improve wound healing of partial thickness burn wounds in a rat model.
    Burns 2017 Oct 9. Epub 2017 Oct 9.
    Association of Dutch Burn Centres, Beverwijk, The Netherlands; Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands; Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands. Electronic address:
    The Renin Angiotensin System is involved in fibrotic pathologies in various organs such as heart, kidney and liver. Inhibition of this system by angiotensin converting enzyme antagonists, such as Captopril, has been shown beneficial effects on these pathologies. Captopril reduced the inflammatory reaction but also directly influenced the fibrotic process. Read More

    Safety and efficacy of uninterrupted perioperative enteral feeding in pediatric burn patients.
    Burns 2017 Oct 9. Epub 2017 Oct 9.
    Burn Program, Division of Pediatric Surgery, Nationwide Children's Hospital, The Ohio State University, United States.
    Introduction: Burn injuries are a significant cause of morbidity. Early enteral nutrition has been shown to improve outcomes, however enteral nutrition is often held for procedures receiving general anesthesia. Limited data is available on uninterrupted perioperative nutrition in pediatric burn patients. Read More

    Long term mortality in critically ill burn survivors: Methodological issues.
    Burns 2017 Oct 9. Epub 2017 Oct 9.
    Managerial Epidemiology Research Center, Department of Public Health, School of Nursing and Midwifery, Maragheh University of Medical Sciences, Maragheh, Iran; Department of Epidemiology & Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

    Outcomes important to burns patients during scar management and how they compare to the concepts captured in burn-specific patient reported outcome measures.
    Burns 2017 Oct 11. Epub 2017 Oct 11.
    Membership of the Pegasus Study Group is provided in the Acknowledgements.
    Background: Pressure garment therapy (PGT) is an established treatment for the prevention and treatment of hypertrophic scarring; however, there is limited evidence for its effectiveness. Burn survivors often experience multiple issues many of which are not adequately captured in current PGT trial measures. To assess the effectiveness of PGT it is important to understand what outcomes matter to patients and to consider whether patient-reported outcome measures (PROMs) can be used to ascertain the effect of treatments on patients' health-related quality of life. Read More

    Below the surface: Parents' views on the factors that influence treatment adherence in paediatric burn scar management - A qualitative study.
    Burns 2017 Oct 11. Epub 2017 Oct 11.
    Institute of Applied Health Research, University of Birmingham, Birmingham, UK. Electronic address:
    Introduction: Parents have a crucial role to play in burn scar management for their children at a time that is extremely stressful for them and their child. Scar management treatments such as pressure garment therapy (PGT) require high levels of adherence. There has been a lack of research into the factors that may influence adherence in paediatric burn scar management. Read More

    Burn injury outcomes in patients with pre-existing diabetic mellitus: Risk of hospital-acquired infections and inpatient mortality.
    Burns 2017 Oct 10. Epub 2017 Oct 10.
    Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States; North Carolina Jaycee Burn Center, Chapel Hill, NC, United States. Electronic address:
    Background: Diabetes mellitus (DM) is a major cause of illness and death in the United States, and diabetic patients are at increased risk for burn injury. We therefore sought to examine the impact of pre-existing DM on the risk of inpatient mortality and hospital acquired infections (HAI) among burn patients.

    Methods: Adult patients (≥18 years old) admitted from 2004 to 2013 were analyzed. Read More

    Chemical burns: Diphoterine untangled.
    Burns 2017 Oct 10. Epub 2017 Oct 10.
    Victorian Adult Burns Service, The Alfred Hospital, Melbourne, Victoria, Australia.
    Objective: Diphoterine is a hypertonic, amphoteric, polyvalent and chelating decontamination solution used in the treatment of cutaneous and ocular chemical burns. Due to infrequent use by emergency physicians along with the small number of available studies, its debate in the literature as to its efficacy and safety remains inconclusive.

    Methods: A structured literature search was performed in MEDLINE, EMBASE BIOLOGICAL ABSTRACTS and TOXNET to June 2016 for original English-language studies reporting on the safety and effectiveness of Diphoterine. Read More

    Intensive insulin therapy, insulin sensitisers and insulin secretagogues for burns: A systematic review of effectiveness and safety.
    Burns 2017 Oct 10. Epub 2017 Oct 10.
    The Joanna Briggs Institute, Faculty of Health Science, University of Adelaide, North Adelaide, 55 King William Street, 5006 South Australia, Australia. Electronic address:
    This systematic review investigated the effectiveness and safety of intensive insulin therapy (IIT), insulin secretagogues and sensitisers in burn patients. PubMed, Embase, and Cochrane central were searched from 1990 to 2016. Read More

    The clinical utility of extracorporeal shock wave therapy for burn pruritus: A prospective, randomized, single-blind study.
    Burns 2017 Oct 10. Epub 2017 Oct 10.
    Department of Rehabilitation Medicine, Hangang Sacred Heart Hospital, College of Medicine Hallym University, Seoul, Republic of Korea. Electronic address:
    Purposes: To investigate the effect and mechanisms of extracorporeal shock wave therapy (ESWT) on burn scar pruritus.

    Methods: Forty-six patients participated (experimental group, n=23; sham stimulation group, n=23). Patients had complaints of severe pruritus ranging from 5 to 10 on the visual analog scale. Read More

    Improving mortality outcomes of Stevens Johnson syndrome/toxic epidermal necrolysis: A regional burns centre experience.
    Burns 2017 Oct 10. Epub 2017 Oct 10.
    St Andrew's Centre for Plastic Surgery and Burns, Chelmsford, UK.
    Introduction: Stevens Johnson Syndrome/toxic epidermal necrolysis (SJS/TEN) are rare, potentially fatal desquamative disorders characterised by large areas of partial thickness skin and mucosal loss. The degree of epidermal detachment that occurs has led to SJS/TEN being described as a burn-like condition. These patients benefit from judicious critical care, early debridement and meticulous wound care. Read More

    Hospitalized burns in Finland: 36305 cases from 1980-2010.
    Burns 2017 Oct 10. Epub 2017 Oct 10.
    Helsinki Burn Centre, Department of Plastic Surgery, University of Helsinki and Helsinki University Hospital, P.O. Box 266, FI-00029 HUS, Helsinki, Finland. Electronic address:
    To analyse the epidemiology of burns in Finland, a comprehensive study was conducted among all hospitalized burn patients between 1980 and 2010. All patients with burn injury as the main diagnosis, 36305 cases in total, treated in the public and private sectors, were included. Patient data were obtained from the Finnish Hospital Discharge Register (FHDR). Read More

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