5,938 results match your criteria Burn Wound Infections

In-situ synthesis silver nanoparticles in chitosan/Bletilla striata polysaccharide composited microneedles for infected and susceptible wound healing.

Int J Biol Macromol 2022 Jun 22. Epub 2022 Jun 22.

Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, PR China. Electronic address:

A novel antibacterial strategy is urgently required to develop for solving bacterial biofilm obstruction and bacterial drug resistance in the infected wound healing process. Herein, the Chitosan/Bletilla striata polysaccharide composited microneedles were prepared by chitosan, tannic acid, AgNO and Bletilla striata polysaccharide through step centrifugation. In our design system, the porous structure of microneedles gradually disappeared, and the mechanical properties were significantly improved after multiple fillings. Read More

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Contribution of Topical Agents such as Hyaluronic Acid and Silver Sulfadiazine to Wound Healing and Management of Bacterial Biofilm.

Medicina (Kaunas) 2022 Jun 20;58(6). Epub 2022 Jun 20.

Department of Plastic and Reconstructive Surgery, Faculty of Medicine, Fukuoka University, Fukuoka 814-0180, Japan.

Wound healing is commonly associated with critical bacterial colonization or bacterial infection, which induces prolonged inflammation, resulting in delayed re-epithelialization. An appropriate wound dressing requires a humid environment, which also functions as a barrier against bacterial contamination and will accelerate a regenerative response of the wound. Silver sulfadiazine (SSD) is used to prevent wound infection. Read More

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Characterization of Candida albicans and Staphylococcus aureus polymicrobial biofilm on different surfaces.

Rev Iberoam Micol 2022 Jun 20. Epub 2022 Jun 20.

Institute for Social Security and Services for State Workers (ISSSTE), Aguascalientes, Mexico.

Background: Staphylococcus aureus and Candida albicans have been co-isolated from biofilm-associated diseases such as denture stomatitis, periodontitis, and burn wound infections, as well as from medical devices. However, the polymicrobial biofilm of both microorganisms has not been fully characterized.

Aims: To characterize the polymicrobial biofilm of C. Read More

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Extracorporeal Blood Purification in Burns: For Whom, Why, and How?

Blood Purif 2022 Jun 23:1-8. Epub 2022 Jun 23.

Anesthesiology and Intensive Care Medicine, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.

Patients with serious thermal burn injuries require immediate and specialized care in order to minimize morbidity and mortality. Optimal fluid resuscitation, nutritional support, pulmonary care, burn wound care, and infection control practices represent key aspects of patient care in burn centers. When severely burned, the patient usually presents a systemic inflammatory response syndrome, soon balanced by a counter anti-inflammatory response syndrome. Read More

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Application of Negative Pressure Therapy on Skin Grafts after Soft-Tissue Reconstruction: A Prospective Observational Study.

Clin Pract 2022 Jun 7;12(3):396-405. Epub 2022 Jun 7.

Plastic Surgery and Burn Unit, Dr. Soliman Fakeeh Hospital, P.O. Box 2537, Jeddah 21461, Saudi Arabia.

A split-thickness skin graft (STSG) is one of the main tools used in the reconstruction of skin defects. Negative-pressure wound therapy (NPWT) has been widely used as adjunct therapy for wound healing for decades. Few studies have conducted the outcomes of NPWT use as a postoperative dressing for STSGs. Read More

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Detection of Metallo Beta-Lactamase (MBL) Producing in a Tertiary Care Hospital, Ghanpur, Medchal, India.

Maedica (Bucur) 2022 Mar;17(1):134-142

Department of Medicine, All India Institute of Medical Sciences, Bibinagar, India.

Pseudomonas aeruginosa is a leading cause of nosocomial infections and is especially prevalent among patients with burn wounds, cystic fibrosis, acute leukemia, organ transplants and intravenous-drug addiction. Acquired metallo-â-lactamases (MBLs) are carbapenemases which require zinc in the active site and are predominantly produced by They belong to Ambler's class B and Bush-Jacoby Medeiros Group 3 and hydrolyse virtually all â-lactam agents, including the carbapenems. In India, only blaVIM and NDM-1 have been reported in Metallo beta-lactamases have recently emerged as one of the most worrisome resistance mechanisms owing to their capacity to hydrolyse all beta-lactams, including carbapenems. Read More

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Commercial wound dressings for the treatment of exuding wounds: an in-depth physico-chemical comparative study.

Burns Trauma 2022 21;10:tkac024. Epub 2022 Jun 21.

Smart Polymeric Biomaterials Research Group, Biomaterials and Tissue Engineering (SIEM) @ Campus Group T Leuven, Andreas Vesaliusstraat 13, 3000 Leuven, Belgium.

Background: Nowadays, a wide range of wound dressings is already commercially available. The selection of the dressing is of paramount importance as inappropriate wound management and dressing selection can delay the wound healing process. Not only can this be distressing for the patient, but it can also contribute to complications such as maceration and subsequent infection. Read More

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Exploring the therapeutic potential of acetonic plant extracts in the healing of skin wounds infected with multidrug resistant pathogens.

J Appl Biomed 2022 Jun 6;20(2):45-55. Epub 2022 Jun 6.

Botany Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt.

Open wounds are easily susceptible to infection by multi-drug resistant (MDR) pathogens. The emergence of MDR super bacteria such as Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus spp, fungi such as Aspergillus niger and Candida spp, has been identified to significantly increase the incidence rate. Therefore, it is necessary to develop a suitable barrier to prevent infection and enhance wound healing. Read More

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Transcriptomics combined with metabolomics analysis of the mechanism of agmatine in the treatment of septic liver injury.

Ann Transl Med 2022 May;10(10):578

State Key Laboratory of Trauma, Burns and Combined Injury, Department of Wound Infection and Drug, Daping Hospital, Army Medical University, Chongqing, China.

Background: Acute liver injury can occur at any stage of sepsis and is an important sign of multiple organ dysfunction syndrome (MODS). Studies have shown that agmatine (AGM) can effectively improve liver injury caused by sepsis. However, due to the numerous metabolites and metabolic pathways of AGM in the human body, its mechanism in treating septic liver injury is unclear. Read More

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The Meek micrograft technique for burns; review on its outcomes: Searching for the superior skin grafting technique.

Burns 2022 May 13. Epub 2022 May 13.

Burn Centre, Red Cross Hospital, Vondellaan 13, Beverwijk 1942 LE, the Netherlands; Department of Pediatric Surgery, Amsterdam UMC, AMC, Meibergdreef 9, Amsterdam 1105 AZ, the Netherlands; Department Surgery, Red Cross Hospital, Vondellaan 13, Beverwijk 1942 LE, the Netherlands. Electronic address:

Introduction: Autologous split thickness skin grafting is the standard-of-care for the majority of deep dermal and full thickness burns: Meshed grafting is most commonly used. Patients with extensive burn injuries have limited donor site availability. Meek micrografting is a well-known technique to enable larger expansions. Read More

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Lycium barbarum polysaccharide promotes corneal Re-epithelialization after alkaline injury.

Exp Eye Res 2022 Jun 14;221:109151. Epub 2022 Jun 14.

Department of Ophthalmology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region. Electronic address:

Chemical injury of the cornea results in epithelial defect and subsequent stromal scarring and infection. Our study aims to evaluate the effectiveness of pre-treatment of Lycium barbarum polysaccharide (LBP) in promoting corneal re-epithelialization after alkaline burn. The corneas of C57BL/6J mice were pre-treated with topical phosphate-buffered saline or LBP (0. Read More

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[Application of free transverse gracilis myocutaneous flap for soft tissue defects of foot and ankle].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2022 Jun;36(6):766-769

Department of Trauma and Microreconstructive Surgery, Orthopaedic Center, the First Affiliated Hospital of Xinjiang Medical University, Urumqi Xinjiang, 830054, P. R. China.

Objective: To investigate the effectiveness of free transverse gracilis myocutaneous flap for soft tissue defects of foot and ankle.

Methods: Between January 2017 and December 2020, 16 cases (17 feet) of soft tissue defects of foot and ankle were repaired with free transverse gracilis myocutaneous flaps. There were 10 males and 6 females, with an average age of 38 years (range, 23-60 years). Read More

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Robust antibacterial activity of functionalized carbon nanotube- levofloxacine conjugate based on in vitro and in vivo studies.

Sci Rep 2022 Jun 16;12(1):10064. Epub 2022 Jun 16.

Department of Biochemistry, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

A new nano-antibiotic was synthesized from the conjugation of multi-walled carbon nanotubes with levofloxacin (MWCNT-LVX) through covalent grafting of drug with surface-modified carbon nanotubes in order to achieve an effective, safe, fast-acting nano-drug with the minimal side effects. This study is the first report on the evaluation of in vitro cell viability and antibacterial activity of nano-antibiotic along in addition to the in vivo antibacterial activity in a burn wound model. The drug-loading and release profile at different pH levels was determined using an ultraviolet-visible spectrometer. Read More

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Antibiotic-loaded Bone Cement Combined with Vacuum-assisted Closure Facilitating Wound Healing in Wagner 3-4 Diabetic Foot Ulcers.

Int J Low Extrem Wounds 2022 Jun 15:15347346221109045. Epub 2022 Jun 15.

Department of Vascular Surgery, 527527The Affiliated Qingdao Central Hospital of Qingdao University, Qingdao, Shandong, PR China.

This study explored the clinical effectiveness of antibiotic-loaded bone cement (ALBC) combined with vacuum-assisted closure (VAC) on the treatment of Wagner 3-4 diabetic foot ulcers (DFUs). This is a retrospective study, including 32 patients with Wagner 3-4 DFUs who had undergone treatment between August 2019 and June 2021. Patient age, sex, Hemoglobin A1c (HbA1c), body mass index (BMI), ankle brachial index (ABI), white blood cells (WBC), C-reactive protein (CRP) levels, comorbidities and wound closure methods were recorded. Read More

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Patterns of multidrug resistant organism acquisition in an adult specialist burns service: a retrospective review.

Antimicrob Resist Infect Control 2022 Jun 13;11(1):82. Epub 2022 Jun 13.

Department of Infectious Diseases, The Alfred Hospital and Central Clinical School, Monash University, Melbourne, Australia.

Background: Multidrug resistant organisms (MDROs) occur more commonly in burns patients than in other hospital patients and are an increasingly frequent cause of burn-related mortality. We examined the incidence, trends and risk factors for MDRO acquisition in a specialist burns service housed in an open general surgical ward, and general intensive care unit.

Methods: We performed a retrospective study of adult patients admitted with an acute burn injury to our specialist statewide tertiary burns service between July 2014 and October 2020. Read More

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Single-step antibiotic-mediated synthesis of kanamycin-conjugated gold nanoparticles for broad-spectrum antibacterial applications.

Lett Appl Microbiol 2022 Jun 10. Epub 2022 Jun 10.

Department of Medical Biotechnology, Center for Interdisciplinary Research, D.Y. Patil Education Society (Institution Deemed to be University), Kolhapur, Maharashtra, India.

Widespread and irrational use of antibiotics results in the development of antibiotic-resistant bacteria. Thus, there is a need to develop novel antibacterial agents in order to replace conventional antibiotics and to increase the efficacy of already existing antibiotics by combining them with other materials. Herein, a single-step antibiotic-mediated synthesis of antibiotic-conjugated gold nanoparticles is reported. Read More

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Association Between Variants of the Mannose-Binding Lectin 2 Gene and Susceptibility to Sepsis in the Hainan Island.

Med Sci Monit 2022 Jun 8;28:e936134. Epub 2022 Jun 8.

State Key Laboratory of Trauma, Burns and Combined Injury, Department of Wound Infection and Drug, Army Medical Center (Daping Hospital), Army Medical University, Chongqing, China (mainland).

BACKGROUND Sepsis has emerged as a leading cause of death in the intensive care unit. A growing number of studies have shown that genetic variants, especially single nucleotide polymorphisms, are key determinants of inter-individual variation in sepsis response. Therefore, early prediction of the onset and progression of sepsis, along with early intervention in high-risk patients, should be performed to effectively reduce the morbidity and mortality of the disease. Read More

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Photo-Crosslinked Antimicrobial Hydrogel Exhibiting Wound Healing Ability and Curing Infections In Vivo.

Adv Healthc Mater 2022 Jun 3:e2200536. Epub 2022 Jun 3.

Antimicrobial Research Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru, Karnataka, 560064, India.

With the increasing focus on healthcare research in the current times, therapeutic and biomaterial interventions for healing of wounds and mitigation of wound-associated infections have seen expedited progress. Conventional approaches consist of release-active gels, which demonstrate leaching of antimicrobials, such as antibiotics, metal ions, etc. However, these systems suffer from the disadvantages of burst release, reservoir exhaustion, and associated toxicity. Read More

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Light-activated molecular machines are fast-acting broad-spectrum antibacterials that target the membrane.

Sci Adv 2022 Jun 1;8(22):eabm2055. Epub 2022 Jun 1.

Department of Chemistry, Rice University, Houston, TX 77005, USA.

The increasing occurrence of antibiotic-resistant bacteria and the dwindling antibiotic research and development pipeline have created a pressing global health crisis. Here, we report the discovery of a distinctive antibacterial therapy that uses visible (405 nanometers) light-activated synthetic molecular machines (MMs) to kill Gram-negative and Gram-positive bacteria, including methicillin-resistant , in minutes, vastly outpacing conventional antibiotics. MMs also rapidly eliminate persister cells and established bacterial biofilms. Read More

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pH-Responsive PVA/BC--GO Dressing Materials for Burn and Chronic Wound Healing with Curcumin Release Kinetics.

Polymers (Basel) 2022 May 11;14(10). Epub 2022 May 11.

BioInspired Device and Tissue Engineering Research Group, School of Biomedical Engineering and Health Sciences, Universiti Teknologi Malaysia, Johor Bahru 81300, Johor, Malaysia.

Polymeric materials have been essential biomaterials to develop hydrogels as wound dressings for sustained drug delivery and chronic wound healing. The microenvironment for wound healing is created by biocompatibility, bioactivity, and physicochemical behavior. Moreover, a bacterial infection often causes the healing process. Read More

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Antibacterial Effects of Methanolic Extract on Wound Healing.

Molecules 2022 May 21;27(10). Epub 2022 May 21.

Faculty of Medicine, Taif University, Taif 21944, Saudi Arabia.

() is a small tree distributed throughout the Middle East. It was traditionally used in perfumes in countries in this area. In Saudi Arabia, it was used to treat wounds burns and as an antidote to scorpion stings. Read More

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Paediatric Partial-Thickness Burn Therapy: A Meta-Analysis and Systematic Review of Randomised Controlled Trials.

Life (Basel) 2022 Apr 21;12(5). Epub 2022 Apr 21.

Department of Thermophysiology, Institute for Translational Medicine, Medical School, University of Pécs, 12 Szigeti Street, H7624 Pécs, Hungary.

Background: Paediatric second-degree burn injuries are a significant source of medical challenges to the population that may cause severe, lifelong complications. Currently, there are dozens of therapeutic modalities and we aimed to summarise their reported outcomes and determine their effectiveness, compared to the widely used silver sulphadiazine (SSD).

Methods: We conducted the meta-analysis and systematic review of randomised controlled trials (RCTs), which investigated the performance of dressings in acute paediatric partial-thickness burns. Read More

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The application of the WSES classification system for open pelvic fractures-validation and supplement from a nationwide data bank.

World J Emerg Surg 2022 05 27;17(1):29. Epub 2022 May 27.

Department of Trauma and Burn Surgery, Stroger Hospital of Cook County, Rush University, 8th floor, 1950 West Polk Street, Chicago, IL, 60612, USA.

Background: Open pelvic fractures are rare but complex injuries. Concomitant external and internal hemorrhage and wound infection-related sepsis result in a high mortality rate and treatment challenges. Here, we validated the World Society Emergency Society (WSES) classification system for pelvic injuries in open pelvic fractures, which are quite different from closed fractures, using the National Trauma Data Bank (NTDB). Read More

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Burn Injury-Induced Extracellular Vesicle Production and Characteristics.

Shock 2022 Jun 25;57(6):228-242. Epub 2022 May 25.

Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, Florida.

Abstract: Extracellular vesicles (EVs) are nano-sized membrane-bound particles containing biologically active cargo molecules. The production and molecular composition of EVs reflect the physiological state of parent cells, and once released into the circulation, they exert pleiotropic functions via transferring cargo contents. Thus, circulating EVs not only serve as biomarkers, but also mediators in disease processes or injury responses. Read More

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Challenges and innovations in treating chronic and acute wound infections: from basic science to clinical practice.

Burns Trauma 2022 21;10:tkac014. Epub 2022 May 21.

School of Pharmacy, Jiangsu Provincial Engineering Research Center of Traditional Chinese Medicine External Medication Development and Application, Nanjing University of Chinese Medicine, Nanjing 210023, People's Republic of China.

Acute and chronic wound infection has become a major worldwide healthcare burden leading to significantly high morbidity and mortality. The underlying mechanism of infections has been widely investigated by scientist, while standard wound management is routinely been used in general practice. However, strategies for the diagnosis and treatment of wound infections remain a great challenge due to the occurrence of biofilm colonization, delayed healing and drug resistance. Read More

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Management of Acutely Symptomatic Hernia (MASH) study.

Br J Surg 2022 May 24. Epub 2022 May 24.

Academic Directorate of General Surgery, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

Background: Acutely symptomatic abdominal wall and groin hernias are a common reason for acute surgical hospital admissions. There are limited data to guide the treatment of these patients. This study aimed to assess outcomes of emergency hernia surgery and identify common management strategies, to improve care for these high-risk patients. Read More

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Seroprevalence of SARS-CoV-2 antibody among urban Iranian population: findings from the second large population-based cross-sectional study.

BMC Public Health 2022 May 23;22(1):1031. Epub 2022 May 23.

Digestive Diseases Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, 14117-13135, Iran.

Background: The first large serosurvey in Iran found a SARS-CoV-2 antibody seroprevalence of 17.1% among the general population in the first wave of the epidemic by April, 2020. The purpose of the current study was to assess the seroprevalence of COVID-19 infection among Iranian general population after the third wave of the disease. Read More

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Burn Wounds: Proliferating Site for Biofilm Infection.

Appl Biochem Biotechnol 2022 May 23. Epub 2022 May 23.

Department one of Cardiology, Tangshan Worker's Hospital, 063000, Tangshan, Hebei, China.

Burn wounds can create significant damage to human skin, compromising one of the key barriers to infection. The leading cause of death among burn wound patients is infection. Even in the patients that survive, infections can be notoriously difficult to treat and can cause lasting damage, with delayed healing and prolonged hospital stays. Read More

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Multifunctional electrospun asymmetric wettable membrane containing black phosphorus/Rg1 for enhancing infected wound healing.

Bioeng Transl Med 2022 May 15;7(2):e10274. Epub 2021 Dec 15.

Key Laboratory of Biomaterials of Guangdong Higher Education Institutes, Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier Development, Department of Biomedical Engineering Jinan University Guangzhou China.

Bacterial infection is one of the most frequent complications in the burn and chronic wounds. Inspired by natural existing superhydrophobic surface structures, a novel asymmetric wettable membrane was prepared using the electrospinning technique for facilitating the bacteria-infected wound healing. Herein, the prepared membrane consists of two layers: The hydrophobic outer layer was composed of poly (lactic-co-glycolic) acid (PLGA) and black phosphorus-grafted chitosan (HACC-BP), while the hydrophilic inner layer was composed by using a mixture of gelatin (Gel) with ginsenoside Rg1 (Rg1). Read More

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[Retrospective analysis of 35 burn patients in different stages of pregnancy].

Zhonghua Shao Shang Za Zhi 2022 May;38(5):415-421

Department of Burns, Tongren Hospital of Wuhan University&Wuhan Third Hospital, Wuhan 430060, China.

To summarize the clinical outcomes of burn patients in different stages of pregnancy and explore a rational therapeutic scheme for burns during pregnancy. A retrospective observational study was conducted. From June 2010 to June 2020, 21 patients who met the inclusion criteria were admitted to the Department of Burns of Wuhan Third Hospital and 14 patients who met the inclusion criteria were admitted to the Department of Burns of the First Affiliated Hospital of Nanchang University. Read More

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