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    Reconstruction of an Anterior Cervical Necrotizing Fasciitis Defect Using a Biodegradable Polyurethane Dermal Substitute.
    Eplasty 2017 25;17:e3. Epub 2017 Jan 25.
    Adult Burn Centre, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
    Introduction: Although we have previously described the use of a novel polyurethane biodegradable dermal substitute in the reconstruction of 20 free flap donor sites, and extensive cutaneous defects, including a large area of exposed calvarium secondary to burn injury, our experience with this material now extends to 35 free flap donor site reconstructions and 13 major or complex burns. Methods: The polyurethane material (NovoSorb BTM; PolyNovo Biomaterials Pty Ltd, Port Melbourne, Victoria, Australia) was recently employed in another complex wound scenario, implanted into a large anterior cervical cutaneous and soft-tissue defect remaining after serial radical debridement for necrotizing fasciitis. Results: Implantation, integration, delamination, and split-skin graft application proceeded without complication, mirroring our previous experience in other wounds (including major burns). Read More

    Infection in burn patients in a referral center in Colombia.
    Burns 2017 Feb 6. Epub 2017 Feb 6.
    University Hospital of Santander, Universidad Industrial de Santander, Colombia. Electronic address:
    Introduction: Worldwide, burns are responsible for more than 300,000 deaths annually; infection is a major cause of morbidity and mortality in these patients. Early identification and treatment of infection improves outcome. Toward this end it's necessary to identify the institutions flora and organisms that most frequently produces infection. Read More

    Antimicrobial peptide Epinecidin-1 promotes complete skin regeneration of methicillin-resistant Staphylococcus aureus-infected burn wounds in a swine model.
    Oncotarget 2017 Feb 3. Epub 2017 Feb 3.
    Marine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, Jiaushi, Ilan, Taiwan.
    This report shows that the antimicrobial peptide (AMP) Epinecidin-1 (Epi-1) efficiently heals MRSA-infected heat burn injuries and provides protection from infection in a pig model. The presence of an optimal level of Epi-1 induces cell proliferation by promoting cell cycle progression through an increase in S-phase cells. Epi-1 also induces proliferation to cover the wounded region in an in vitro cell proliferation assay using immortalized human epithelial HaCaT cells. Read More

    On-Demand Dissolution of Chemically Cross-Linked Hydrogels.
    Acc Chem Res 2017 Feb 7. Epub 2017 Feb 7.
    Departments of Chemistry, Biomedical Engineering, and Medicine, Boston University , 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
    The formation and subsequent on-demand dissolution of chemically cross-linked hydrogels is of keen interest to chemists, engineers, and clinicians. In this Account, we summarize our recent advances in the area of dissolvable chemically cross-linked hydrogels and provide a comparative discussion of other recent hydrogel systems. Using biocompatible macromonomers, we developed a library of cross-linked dendritic hydrogels that possess favorable properties, including biocompatibility, tissue adhesion, and swelling. Read More

    A systematic review and meta-analysis of clinical outcomes associated with nanocrystalline silver use compared to alternative silver delivery systems in the management of superficial and deep partial thickness burns.
    Burns 2017 Feb 1. Epub 2017 Feb 1.
    Department of Plastic Surgery, Kuopio University Hospital, Kuopio, Finland.
    Objective: The purpose of this systematic review and meta-analysis was to assess the clinical effectiveness of nanocrystalline silver compared to alternative silver delivery systems (silver sulphadiazine [SSD] and silver nitrate) in adults and children with superficial and deep partial thickness burns.

    Methods: PubMed, EMBASE, Cochrane and other databases were searched to identify relevant randomised controlled trials and observational studies.

    Results: Eight studies that assessed both nanocrystalline silver and SSD and one study that compared nanocrystalline silver vs. Read More

    Comparison of clinical outcomes in diabetic and non-diabetic burns patients in a national burns referral centre in southeast Asia: A 3-year retrospective review.
    Burns 2017 Mar 31;43(2):436-444. Epub 2017 Jan 31.
    Department of Anaesthesiology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore. Electronic address:
    Objective: Diabetic burns patients may be at risk of worse clinical outcomes. This study aims to further investigate the impact of diabetes mellitus on clinical outcomes in burns patients in Singapore.

    Methods: A 3-year retrospective review was performed at the Singapore General Hospital Burns Centre (2011-2013). Read More

    Changing trends in antimicrobial susceptibility pattern of bacterial isolates in a burn unit.
    Burns 2017 Jan 30. Epub 2017 Jan 30.
    Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi-95, India. Electronic address:
    Introduction: Emerging antimicrobial resistance in nosocomial bacterial isolates, limits the available treatment options for burn wound infections, among them multi-drug resistant Gram negative bacteria and methicillin-resistant Staphylococcus aureus (MRSA) are major contributors to the increase in morbidity and mortality rates.

    Material And Methods: A retrospective cross-sectional study was done in the Department of Microbiology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi. A total of 818 wound samples from patients admitted in the burn wards and Intensive Care Units (ICUs) examined between 2010-2014 (5 years period). Read More

    Evaluation of Metallo-β-Lactamase-Production and Carriage of bla-VIM Genes in Pseudomonas aeruginosa Isolated from Burn Wound Infections in Isfahan.
    Arch Trauma Res 2016 Dec 12;5(4):e34343. Epub 2016 Jun 12.
    Department of Parasitology and Mycology, School of Medicine, Alborz University of Medical Sciences, Karaj, IR Iran.
    Background: Metallo-β-lactamase-production among Gram-negative bacteria, including Pseudomonas aeruginosa, has become a challenge for treatment of infections due to these resistant bacteria.

    Objectives: The aim of the current study was to evaluate the metallo-β-lactamase-production and carriage of bla-VIM genes among carbapenem-resistant P. aeruginosa isolated from burn wound infections. Read More

    Short Synthetic β-Sheet Antimicrobial Peptides for the Treatment of Multidrug-Resistant Pseudomonas aeruginosa Burn Wound Infections.
    Adv Healthc Mater 2017 Jan 30. Epub 2017 Jan 30.
    Program of Innovative Therapeutics, Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, Key Laboratory of Organ Transplantation, Zhejiang Province, Hangzhou, 310003, China.
    Pseudomonas aeruginosa is often implicated in burn wound infections; its inherent drug resistance often renders these infections extremely challenging to treat. This is further compounded by the problem of emerging drug resistance and the dearth of novel antimicrobial drug discovery in recent years. In the perennial search for effective antimicrobial compounds, the authors identify short synthetic β-sheet folding peptides, IRIKIRIK (IK8L), IRIkIrIK (IK8-2D), and irikirik (IK8D) as prime candidates owing to their high potency against Gram-negative bacteria. Read More

    Linked hospital and primary care database analysis of the impact of short-term complications on recurrence in laparoscopic inguinal hernia repair.
    Hernia 2017 Jan 27. Epub 2017 Jan 27.
    Department of Surgery and Cancer, Imperial College London, London, UK.
    Objective: To study the effects of short-term complications on recurrence following laparoscopic inguinal hernia repair using routine data.

    Background: Linked primary and secondary care databases can evaluate the quality of inguinal hernia surgery by quantifying short- and long-term outcome together.

    Methods: Longitudinal analysis of linked primary care (Clinical Practice Research Datalink) and hospital administrative (Hospital Episodes Statistics) databases quantified 30-day complications (wound infection and bleeding) and surgery for recurrence after primary repair performed between 1st April 1997 and 31st March 2012. Read More

    The Use of Integra® Dermal Regeneration Template for the Orbital Exenteration Socket: A Novel Technique.
    Ophthal Plast Reconstr Surg 2017 Jan 23. Epub 2017 Jan 23.
    Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, U.S.A.
    Purpose: Integra® dermal regeneration template is a bilayer membrane system that acts as a scaffold for regenerating dermal skin cells. It is used for wound reconstruction following burns, extensive injuries, and a large tumor excision in multiple parts of the body. The dermal layer is made of porous matrix of bovine tendon collagen and glycosaminoglycan. Read More

    Hyperbaric Oxygen Therapy for the Compromised Graft or Flap.
    Adv Wound Care (New Rochelle) 2017 Jan;6(1):23-32
    Division of Plastic Surgery, University of Nevada School of Medicine , Las Vegas, Nevada.
    Significance: Tissue grafts and flaps are used to reconstruct wounds from trauma, chronic disease, tumor extirpation, burns, and infection. Despite careful surgical planning and execution, reconstructive failure can occur due to poor wound beds, radiation, random flap necrosis, vascular insufficiency, or ischemia-reperfusion (IR). Traumatic avulsions and amputated composite tissues-compromised tissue-may fail from crush injury and excessively large sizes. Read More

    Low molecular weight chitosan-coated silver nanoparticles are effective for the treatment of MRSA-infected wounds.
    Int J Nanomedicine 2017 4;12:295-304. Epub 2017 Jan 4.
    Department of Burns and Plastic Surgery, Shanghai Ninth People's Hospital, Institute of Traumatic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China; Department of Dermatology, Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA.
    Silver nanoparticles (AgNPs) are being widely applied as topical wound materials; however, accumulated deposition of silver in the liver, spleen, and other main organs may lead to organ damage and dysfunction. We report here that low molecular weight chitosan-coated silver nanoparticles (LMWC-AgNPs) are effective against methicillin-resistant Staphylococcus aureus (MRSA), have better biocompatibility, and have lower body absorption characteristics when compared with polyvinylpyrrolidone-coated silver nanoparticles (PVP-AgNPs) and silver nanoparticles without surface stabilizer (uncoated-AgNPs) in a dorsal MRSA wound infection mouse model. LMWC-AgNPs were synthesized by reducing silver nitrate with low molecular weight chitosan as a stabilizer and reducing agent, while PVP-AgNPs were synthesized using polyvinylpyrrolidone as a stabilizer and ethanol as a reducing agent. Read More

    Burn wound healing: present concepts, treatment strategies and future directions.
    J Wound Care 2017 Jan;26(1):5-19
    Assistant Professor, Division of Regenerative Pharmacology, RAZI Drug Research Centre, Iran University of Medical Sciences, Tehran, Iran; and Division of Surgery and Radiology, Department of Clinical Sciences, School of Veterinary Medicine, Shiraz University, Iran.
    Burns are the most extensive forms of soft tissue injuries occasionally resulting in extensive and deep wounds and death. Burns can lead to severe mental and emotional distress, because of excessive scarring and skin contractures. Treatment of burns has always been a difficult medical problem and many different methods have been used to treat such injuries, locally. Read More

    Antimicrobial activity of photodynamic therapy in combination with colistin against a pan-drug resistant Acinetobacter baumannii isolated from burn patient.
    Photodiagnosis Photodyn Ther 2017 Jan 11. Epub 2017 Jan 11.
    Private practice, Tehran, Iran. Electronic address:
    Nosocomially-acquired multi-, extensively-, and pandrug resistant (MDR, XDR, and PDR) strains of microorganisms such as Acinetobacter baumannii remain a serious cause of infection and septic mortality in burn patients. Treatment of patients with nosocomial burn wound infections is often complicated by drug-resistant strains of A. baumannii. Read More

    Role of cytokines in host defense against Staphylococcus aureus skin infection.
    Histol Histopathol 2017 Jan 12:11867. Epub 2017 Jan 12.
    Department of Burn Surgery, Changhai Hospital, Second Military Medical University, Shanghai, P.R. China.
    Wound infection caused by Staphylococcus aureus (S. aureus) is a critical clinical problem due to long hospitalization times, significant morbidity and mortality, as well as considerable medical resource consumption. With the emergence of methicillin-resistant S. Read More

    [Ten tips for initial assessment and treatment of minor burns].
    Ned Tijdschr Geneeskd 2017 ;161(0):D591
    Brandwondencentrum Rode Kruis Ziekenhuis, afd. Heelkunde en Brandwondengeneeskunde, Beverwijk.
    The initial care of a patient with burns is a challenge for every doctor. After cooling the burn appropriately, a careful history and a good initial assessment are of essential importance for treatment. The burn should be inspected regularly for early detection of any infection and to evaluate wound healing. Read More

    Burn Injury Leads to Increased Long-Term Susceptibility to Respiratory Infection in both Mouse Models and Population Studies.
    PLoS One 2017 9;12(1):e0169302. Epub 2017 Jan 9.
    Burn Injury Research Unit, School of Surgery, University of Western Australia, Perth, Western Australia, Australia.
    Background: Burn injury initiates an acute inflammatory response that subsequently drives wound repair. However, acute disruption to the immune response is also common, leading to susceptibility to sepsis and increased morbidity and mortality. Despite increased understanding of the impact of burn injury on the immune system in the acute phase, little is known about long-term consequences of burn injury on immune function. Read More

    A novel chimeric lysin with robust antibacterial activity against planktonic and biofilm methicillin-resistant Staphylococcus aureus.
    Sci Rep 2017 Jan 9;7:40182. Epub 2017 Jan 9.
    Key Laboratory of Special Pathogens and Biosafety, Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 430071, China.
    Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most threatening pathogens due to its multi-drug resistance (MDR) and strong biofilm-forming capacity. Here, we described the screening of a novel chimeolysin (ClyF) that was active against planktonic and biofilm MRSA. Biochemical tests showed that ClyF was active against all S. Read More

    Bivalent flagellin immunotherapy protects mice against Pseudomonas aeruginosa infections in both acute pneumonia and burn wound models.
    Biologicals 2017 Jan 5. Epub 2017 Jan 5.
    Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
    Pseudomonas aeruginosa infections are a serious challenge to therapy because of the complex pathogenesis and paucity of new effective antibiotics, thus renewing interest in antibody-based therapeutic strategies. Immunotherapy strategies typically target selected virulence factors that are expressed by the majority of clinical strains of P. aeruginosa, particularly because virulence factors mediate infection. Read More

    A prospective intra-individual evaluation of silk compared to Biobrane for the treatment of superficial burns of the hand and face.
    Burns 2016 Dec 30. Epub 2016 Dec 30.
    Clinic of Plastic, Reconstructive, Hand and Burn Surgery, Hospital Cologne Merheim, University of Witten-Herdecke, Germany.
    Introduction: An ever-increasing number of commercially available dressings have been applied to treat superficial burns with the aim to reduce pain and inflammation and lead to a fast wound healing and scar reduction. Nevertheless the search for cheap and effective wound dressing proceeds. Dressilk(®) consisting of silkworm silk showed good results for wound healing in regards to scarring, biocompatibility and reduction of inflammation and pain. Read More

    Experience of distributing 499 burn casualties of the June 28, 2015 Formosa Color Dust Explosion in Taiwan.
    Burns 2016 Dec 28. Epub 2016 Dec 28.
    Department of Public Health, School of Medicine, National Yang-Ming University, Taiwan. Electronic address:
    Objective: To describe the experience of distributing 499 burn casualties of an unexpected event and determine whether patient transfer is associated with patient outcomes measured 2 weeks after the incident.

    Methods: All 499 patients injured in the event were included. For the 138 patients transferred to other hospitals after primary distribution, we evaluated whether the transfers were associated with patient severity. Read More

    Partial-thickness scalds in children: A comparison of different treatment strategies.
    Burns 2016 Dec 28. Epub 2016 Dec 28.
    Department of Surgery, Burn Center, Maasstad Hospital, Rotterdam, The Netherlands.
    Aim: The aim of this study was to compare the clinical outcomes of different treatment strategies for children with partial-thickness scalds at two burn centers. At the first burn center, these burns were treated with a hydrofiber dressing (Aquacel(®), Convatec, Inc.(®), Princeton, NJ, USA) or silver sulfadiazine (SSD, Flammazine(®), Sinclair IS Pharma, London, UK Pharmaceuticals), while at the second burn center, cerium nitrate-silver sulfadiazine (CN-SSD, Flammacerium(®), Sinclair IS Pharma, London, UK Pharmaceuticals) was used. Read More

    Important Developments in Burn Care.
    Plast Reconstr Surg 2017 Jan;139(1):120e-138e
    Toronto, Ontario, and Edmonton, Alberta, Canada From the Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Toronto; and the Divisions of Plastic and Reconstructive Surgery and Critical Care, Department of Surgery, University of Alberta.
    Learning Objectives: After studying this article, the participant should be able to: 1. Explain the epidemiology of severe burn injury in the context of socioeconomic status, gender, age, and burn cause. 2. Read More

    460nm visible light irradiation eradicates MRSA via inducing prophage activation.
    J Photochem Photobiol B 2017 Jan 18;166:311-322. Epub 2016 Dec 18.
    Department of Burns and Plastic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201999, China; Institute of Traumatic Medicine, School of Medicine, Shanghai Jiao Tong University, Shanghai 201999, China. Electronic address:
    A growing number of researches demonstrate that light with a wavelength between 400 and 500nm, namely blue light (BL), has exhibited antibacterial effects on methicillin-resistant Staphylococcus aureus (MRSA) and other microbes. However, there is insufficient evidence to show that BL kills MRSA inside biofilm and the mechanisms underlying the antibacterial effects remain unclear. Here we demonstrate that BL irradiation with 460nm effectively eliminated both planktonic and biofilm MRSA in a dose-dependent manner by utilizing a planktonic MRSA or MRSA biofilm model. Read More

    Elevated prevalence of multidrug-resistant Acinetobacter baumannii with extensive genetic diversity in the largest burn centre of northeast Iran.
    J Glob Antimicrob Resist 2016 Dec 21;8:60-66. Epub 2016 Dec 21.
    Antimicrobial Resistance Research Center, Avicenna Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:
    Objectives: The emergence and spread of multidrug-resistant (MDR) Acinetobacter baumannii isolates is now frequently associated with nosocomial infections. The aim of this study was to evaluate the genetic relatedness and patterns of antimicrobial resistance amongst A. baumannii isolated from a burn centre at a teaching hospital in Iran. Read More

    Silver Sulfadiazine Retards Wound Healing and Increases Hypertrophic Scarring in a Rabbit Ear Excisional Wound Model.
    J Burn Care Res 2017 Jan/Feb;38(1):e418-e422
    From the US Army Institute of Surgical Research/Dental and Craniofacial Trauma Research and Tissue Regeneration, Joint Base Fort Sam Houston, San Antonio, Texas.
    This study evaluated the effects of topical use of silver sulfadiazine cream (SSD) on wound healing and subsequent scarring in a rabbit ear wound model. Seven millimeter full-thickness excisional wounds were created in rabbit ears. Twenty-four rabbits were randomized into four groups in which each group received base cream, 0. Read More

    Targeting bacterial adherence inhibits multidrug-resistant Pseudomonas aeruginosa infection following burn injury.
    Sci Rep 2016 Dec 20;6:39341. Epub 2016 Dec 20.
    Department of Microbiology and Molecular Genetics, University of Texas McGovern Medical School at Houston, Houston, TX, 77030, USA.
    Classical antimicrobial drugs target proliferation and therefore place microbes under extreme selective pressure to evolve resistance. Alternative drugs that target bacterial virulence without impacting survival directly offer an attractive solution to this problem, but to date few such molecules have been discovered. We previously discovered a widespread group of bacterial adhesins, termed Multivalent Adhesion Molecules (MAMs) that are essential for initial binding of bacteria to host tissues and virulence. Read More

    Endothelial dysfunction may play a key role in keloid and hypertrophic scar pathogenesis - Keloids and hypertrophic scars may be vascular disorders.
    Med Hypotheses 2016 Nov 28;96:51-60. Epub 2016 Sep 28.
    Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan.
    Keloids and hypertrophic scars are fibroproliferative disorders (FPDs) of the skin that result from abnormal healing of injured or irritated skin. They can be called pathological or inflammatory scars. Common causes are trauma, burn, surgery, vaccination, skin piercing, folliculitis, acne, and herpes zoster infection. Read More

    Successful treatment of a rare extended retroperitoneal necrotizing soft tissue infection caused by extended-spectrum beta-lactamase-producing Escherichia coli: A case report.
    Medicine (Baltimore) 2016 Dec;95(49):e5576
    aDepartment of Plastic Surgery and Burn bDepartment of Anti-infection cDepartment of Radiology, Peking University First Hospital, Beijing, People's Republic of China.
    Rationale: Retroperitoneal necrotizing soft tissue infection (NSTI) is a rare but life-threatening disease. Here, we present a case of extended retroperitoneal NSTI caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E coli).

    Patient Concerns: The patient complained of progressive redness, swelling, and right flank pain for 10 days, extending to the scrotum for 1 day. Read More

    [Analysis of distribution and drug resistance of pathogens isolated from 541 hospitalized children with burn infection].
    Zhonghua Shao Shang Za Zhi 2016 Nov;32(11):670-675
    Department of Burns, Fujian Medical University Union Hospital, Fuzhou 350001, China.
    Objective: To investigate the distribution and drug resistance of pathogens isolated from hospitalized children with burn infection. Methods: Totally 541 patients were hospitalized in Fujian Medical University Union Hospital, the 180th Hospital of Chinese People's Liberation Army(PLA), the 92th Hospital of PLA, and Longyan First Hospital from January 2013 to December 2015. Totally 848 clinical specimens (blood, catheter tip attachments, wound exudate, etc. Read More

    [Effect of expanded lateral thoracic abdominal flap transferred with pedicle on repairing large area of hypertrophic scar after burn of the upper extremity].
    Zhonghua Shao Shang Za Zhi 2016 Nov;32(11):649-652
    Department of Burns, Zhengzhou First People's Hospital, Zhengzhou 450004, China.
    Objective: To observe the effect of expanded lateral thoracic abdominal flap transferred with pedicle on repairing large area of hypertrophic scar after burn of the upper extremity. Methods: Twelve patients with large area of secondary hypertrophic scar 8 month to 3 years after healing of burn wound on the upper extremity were hospitalized in Zhengzhou First People's Hospital from October 2008 to October 2015, with scar area ranging from 11 cm×7 cm to 20 cm×10 cm. Five patients were with limited straightening and bending of elbow. Read More

    Multilocus Sequence Typing Analysis of Carbapenem-Resistant Acinetobacter baumannii in a Chinese Burns Institute.
    Front Microbiol 2016 9;7:1717. Epub 2016 Nov 9.
    State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University Chongqing, China.
    Acinetobacter baumannii is a leading pathogen responsible for nosocomial infections. The emergence of carbapenem-resistant A. baumannii (CRAB) has left few effective antibiotics for clinicians to use. Read More

    Lesions requiring wound management in a central tertiary neonatal intensive care unit.
    World J Pediatr 2016 Nov 23. Epub 2016 Nov 23.
    Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary.
    Background: Most of the skin disorders that occur in neonatal intensive care units are due in part to the immaturity and vulnerability of the neonatal skin. Various iatrogenic diagnostic and therapeutic procedures are also conducive to iatrogenic damage. This study was to review the neonates admitted to our neonatal intensive care unit who needed wound management, and to assess the most common skin injuries and wounds, and their aetiology. Read More

    Ultra-Early versus Early Excision and Grafting for Thermal Burns up to 60% Total Body Surface Area; A Historical Cohort Study.
    Bull Emerg Trauma 2016 Oct;4(4):197-201
    Student Research Committee, Burn and Wound Healing Research Center, Shiraz University of Medical Science, Shiraz, Iran.
    Objective: To compare the outcome of patients with up to 60% total body surface area (TBSA) thermal burns undergoing ultra-early and early excision and grafting.

    Methods: This historical cohort study was performed in two referral burn centers of Shiraz during a 1-year period from 2015 to 2016. We included those patients with thermal burns up to 60% TBSA who underwent ultra-early (48-72 hours) and early (7-10 days) excision and grafting. Read More

    Glycoside Hydrolases Degrade Polymicrobial Bacterial Biofilms in Wounds.
    Antimicrob Agents Chemother 2017 Feb 24;61(2). Epub 2017 Jan 24.
    Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    The persistent nature of chronic wounds leaves them highly susceptible to invasion by a variety of pathogens that have the ability to construct an extracellular polymeric substance (EPS). This EPS makes the bacterial population, or biofilm, up to 1,000-fold more antibiotic tolerant than planktonic cells and makes wound healing extremely difficult. Thus, compounds which have the ability to degrade biofilms, but not host tissue components, are highly sought after for clinical applications. Read More

    Central Extracorporeal Life Support With Left Ventricular Decompression to Berlin Heart Excor: A Reliable "Bridge to Bridge" Strategy in Crash and Burn Patients.
    Artif Organs 2016 Nov 8. Epub 2016 Nov 8.
    Department of Cardiac Surgery, Heart and Marfan Center, University of Heidelberg, Heidelberg.
    The aim of this study was to compare patients with severe biventricular heart failure who underwent Berlin Heart Excor implantation with (cardiogenic shock [CS] status) or without the need for preoperative extracorporeal life support (ECLS) as a bridge to long-term device. A total of 40 consecutive patients with severe biventricular heart failure underwent Berlin Heart Excor implantation with (CS status, n = 20, 50%) or without (control, n = 20, 50%) the need for preoperative ECLS as a bridge to long-term device from March 2007 to May 2015 at our institution. Demographics and preoperative baseline characteristics as well as early and long-term outcomes including mortality and complication rates were retrospectively compared between the two groups. Read More

    Electrospun mupirocin loaded polyurethane fiber mats for anti-infection burn wound dressing application.
    J Biomater Sci Polym Ed 2017 Feb 1;28(2):162-176. Epub 2016 Dec 1.
    b Alan G. MacDiarmid Institute , Jilin University , Changchun , PR China.
    Wound care treatment is a serious issue faced by the medical staffs due to its variety and complexity. Wound dressings are typically used to manage the various types of wounds. In this study, polyurethane (PU) fibers containing mupirocin (Mu), a commonly used antibiotic in wound care, were fabricated via electrospinning technique. Read More

    Biomaterials and Nanotherapeutics for Enhancing Skin Wound Healing.
    Front Bioeng Biotechnol 2016 31;4:82. Epub 2016 Oct 31.
    Department of Biomedical Engineering, University of Texas at Austin, Austin, TX, USA; Institute for Biomaterials, Drug Delivery and Regenerative Medicine, University of Texas at Austin, Austin, TX, USA; Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA; Institute for Computational Engineering and Sciences, University of Texas at Austin, Austin, TX, USA.
    Wound healing is an intricate process that requires complex coordination between many cell types and an appropriate extracellular microenvironment. Chronic wounds often suffer from high protease activity, persistent infection, excess inflammation, and hypoxia. While there has been intense investigation to find new methods to improve cutaneous wound care, the management of chronic wounds, burns, and skin wound infection remain challenging clinical problems. Read More

    Passive immunization against Pseudomonas aeruginosa recombinant PilA in a murine burn wound model.
    Microb Pathog 2016 Dec 9;101:83-88. Epub 2016 Nov 9.
    Department of Bacteriology and Virology, Shiraz University of Medical Sciences, Shiraz, Iran; Shiraz HIV/AIDS Research Center (SHARC), Shiraz, Iran. Electronic address:
    Pseudomonas aeruginosa type IV pili have an essential role in twitching motility, colonization and biofilm formation. In this study, we investigated the efficacy of intraperitoneal administration of rabbit anti-recombinant PilA (anti-r-PilA) immunoglobulin G (IgG) against P. aeruginosa infection in a mouse burn-wound model. Read More

    Antibodies raised against divalent type b flagellin and pilin provide effective immunotherapy against Pseudomonas aeruginosa infection of mice with burn wounds.
    Biologicals 2017 Jan 9;45:20-26. Epub 2016 Nov 9.
    Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:
    Burn wound infections caused by multidrug-resistant Pseudomonas aeruginosa strains are a serious challenge to therapy because of the complex pathogenesis and paucity of new effective antibiotics. Therefore, there is renewed interest in developing antibody-based therapeutic strategies. Immunotherapy strategies typically target selected virulence factors that are expressed by the majority of clinical strains of P. Read More

    Hold the Pendulum: Rates of Acute Kidney Injury are Increased in Patients Who Receive Resuscitation Volumes Less than Predicted by the Parkland Equation.
    Ann Surg 2016 Dec;264(6):1142-1147
    *Department of Surgery, Sunnybrook Health Sciences Centre and Division of General Surgery, University of Toronto, Toronto, Canada †Shriners Hospitals for Children - Galveston and Department of Surgery, University of Texas Medical Branch, Galveston, TX ‡Sealy Center for Molecular Medicine and the Institute for Translational Science, University of Texas Medical Branch, Galveston, TX §Department of Surgery, Loyola University Stritch School of Medicine, Maywood, IL ¶Department of Surgery, University of Washington School of Medicine, Harborview Medical Center, Seattle, WA ||Department of Surgery, University of Texas Southwestern Medical School, Dallas, TX **Department of Surgery, Massachusetts General Hospital, Shriners Hospital for Children, Harvard Medical School, Boston, MA ††Ross Tilley Burn Centre Sunnybrook Health Sciences Centre and Division of Plastic Surgery University of Toronto, Toronto, ON, Canada.
    Objective: To determine whether restrictive fluid resuscitation results in increased rates of acute kidney injury (AKI) or infectious complications.

    Background: Studies demonstrate that patients often receive volumes in excess of those predicted by the Parkland equation, with potentially detrimental sequelae. However, the consequences of under-resuscitation are not well-studied. Read More

    Emerging Carbapenem-Resistant Pseudomonas aeruginosa Isolates Carrying blaIMP Among Burn Patients in Isfahan, Iran.
    Arch Trauma Res 2016 Sep 11;5(3):e33664. Epub 2016 Jun 11.
    University of Maryland College Park, Maryland, United States of America.
    Background: Metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa is a significant pathogen in burn patients.

    Objectives: The aim of this study was to determine the prevalence of carbapenem-resistant P. aeruginosa isolates, including those resistant to imipenemase (IMP), in a burn unit in Isfahan, Iran. Read More

    Fungal Infection in Thermal Burns: A Prospective Study in a Tertiary Care Centre.
    J Clin Diagn Res 2016 Sep 1;10(9):PC05-PC07. Epub 2016 Sep 1.
    Student, Government Medical College , Amritsar, Punjab, India .
    Introduction: Burn Wound Infection (BWI) is primarily caused by aerobic bacteria followed by fungi, anaerobes and viruses. There has been a worldwide decrease in incidence of bacterial infections in burns due to better patient care and availability of effective antibiotics. Consequently, the fungal burn wound infection has shown an increasing trend. Read More

    Detection of Circulating Mucorales DNA in Critically Ill Burn Patients: Preliminary Report of a Screening Strategy for Early Diagnosis and Treatment.
    Clin Infect Dis 2016 Nov 17;63(10):1312-1317. Epub 2016 Aug 17.
    Université Paris Diderot, Sorbonne Paris Cité.
    Background:  Invasive wound mucormycosis (IWM) is associated with an extremely poor outcome among critically ill burn patients. We describe the detection of circulating Mucorales DNA (cmDNA) for the early diagnosis of IWM in those patients and report the potential value of detecting cmDNA for treatment guidance.

    Methods:  Severely ill burn patients admitted to our tertiary referral center between October 2013 and February 2016 were included. Read More

    Local Probiotic Therapy with Lactobacillus plantarum Mitigates Scar Formation in Rabbits after Burn Injury and Infection.
    Surg Infect (Larchmt) 2017 Feb/Mar;18(2):119-127. Epub 2016 Oct 27.
    1 McGowan Institute for Regenerative Medicine , Pittsburgh, Pennsylvania.
    Background: Infection is the most common complication in burn-injured patients and is believed to contribute to the hypertrophic scarring frequently observed in such injury. Pseudomonas aeruginosa is a common pathogen in burn wound infection. We examined the effect of local probiotic therapy with Lactobacillus plantarum on the severity of the scarring following burn wounding and infection with P. Read More

    Hyperbaric oxygen therapy as additional treatment in deep sternal wound infections - a single center's experience.
    Kardiochir Torakochirurgia Pol 2016 Sep 30;13(3):198-202. Epub 2016 Sep 30.
    Department of Cardiovascular Surgery and Transplantation, Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland.
    Introduction: Deep sternal wound infection (DSWI) is one of the most serious complications after cardiac surgery procedures, observed in 5% of patients. Current standard medical therapy for DSWI includes antibiotics, surgical debridement, resuturing or negative pressure wound therapy (NPWT). Unfortunately, in some cases these methods are insufficient, and additional therapeutic options are needed. Read More

    Local Application of Probiotic Bacteria Prophylaxes against Sepsis and Death Resulting from Burn Wound Infection.
    PLoS One 2016 25;11(10):e0165294. Epub 2016 Oct 25.
    Department of Plastic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America.
    Objective: To determine if local prophylactic application of probiotic bacteria to burn wounds will prevent death in a mouse model of burn wound sepsis.

    Background: Infection remains the most common complication after burn injury and can result in sepsis and death, despite the use of topical and systemic antibiotics. Pseudomonas aeruginosa is a frequently implicated pathogen. Read More

    Burn injuries and soft tissue traumas complicated by mucormycosis infection: a report of six cases and review of the literature.
    Ann Burns Fire Disasters 2015 Dec;28(4):280-287
    Mucor fungus infection is a rare opportunistic infection, rapidly progressive and often fatal in immunocompromised patients, or in patients with chronic debilitating diseases. We report six cases of trauma patients with mucormycosis. Three had severe thermal burns, one of them with a medical history of diabetes mellitus. Read More

    Are There Factors Predictive of Postoperative Complications in Circumferential Contouring of the Lower Trunk? A Meta-Analysis.
    Aesthet Surg J 2016 Nov 8;36(10):1143-1154. Epub 2016 Jul 8.
    Drs Carloni, Watier, and Bertheuil are Plastic and Reconstructive Surgeons, and Dr Girard is a Fellow, Department of Plastic, Reconstructive, and Aesthetic Surgery, Hospital Sud, University of Rennes, Rennes, France. Dr Naudet is a Psychiatrist and Methodologist, Department of Psychiatry, Centre Hospitalier Guillaume Régnier, Rennes, France. Dr Chaput is a Plastic and Reconstructive Surgeon, Department of Plastic, Reconstructive, and Aesthetic Surgery, Rangueil Hospital, Paul Sabatier University, Toulouse, France. Dr de Runz is a Plastic and Reconstructive Surgeon, Department of Maxillofacial, Plastic, Reconstructive, and Cosmetic Surgery, Nancy University Hospital, Nancy, France. Dr Herlin is a Plastic and Reconstructive Surgeon, Department of Plastic Surgery and Burn Surgery, Hospital Lapeyronie, Montpellier University Hospital, Montpellier, France.
    Background: The massive weight loss patient may require a circumferential contouring of the lower trunk.

    Objectives: To summarize the complication rates and explore the possibility of predictive risk factors for complications.

    Methods: We performed a systematic review using the PubMed and Cochrane databases to identify published articles on the topic. Read More

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