Search our Database of Scientific Publications and Authors

I’m looking for a

    4579 results match your criteria Burn Wound Infections

    1 OF 92

    Antimicrobial Chemotherapy has a Linear Relationship to the Proportion of Gram-Negative Isolates from Pediatric Burn Wounds.
    Klin Padiatr 2018 Jan 18;230(1):39-43. Epub 2018 Jan 18.
    Children's Hospital, University Medical Center, Mainz, Germany.
    Wound infection in burns is a relevant cause of morbidity and mortality in children. We aimed to determine the relationship between antibacterial chemotherapy and Gram-negative burn wound colonization and infection. All children admitted to the pediatric intensive care unit for burn trauma from June 1, 2005 to January 31, 2013 were included. Read More

    Frontline Science: Anti-PD-L1 protects against infection with common bacterial pathogens after burn injury.
    J Leukoc Biol 2018 Jan 21;103(1):23-33. Epub 2017 Dec 21.
    Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
    Burn patients are susceptible to infections due, in part, to immune dysfunction. Upregulation of programmed death-1 (PD-1) receptor on T cells and programmed cell death ligand-1 (PD-L1) on myeloid cells contribute to immune dysfunction in nonburn-related sepsis. We hypothesized that PD-1/PDL1 interactions contribute to immune dysfunction after burn injury. Read More

    Essential oil-loaded lipid nanoparticles for wound healing.
    Int J Nanomedicine 2018 27;13:175-186. Epub 2017 Dec 27.
    Department of Drug Sciences, University of Pavia, Pavia.
    Chronic wounds and severe burns are diseases responsible for severe morbidity and even death. Wound repair is a crucial process and tissue regeneration enhancement and infection prevention are key factors to minimize pain, discomfort, and scar formation. The aim of this work was the development of lipid nanoparticles (solid lipid nanoparticles and nanostructured lipid carriers [NLC]), to be loaded with eucalyptus or rosemary essential oils and to be used, as medical devices, to enhance healing of skin wounds. Read More

    Retroperitoneal Necrotizing Fasciitis from Fournier's Gangrene in an Immunocompromised Patient.
    Case Rep Surg 2017 3;2017:5290793. Epub 2017 Dec 3.
    The Arizona Burn Center, Maricopa Integrated Health System, Phoenix, AZ, USA.
    Introduction: Necrotizing fasciitis (NF) is a devastating soft tissue disease causing fulminant clinical deterioration, and extension into the retroperitoneum has a high mortality rate. This disease process demands a strong clinical suspicion for early identification which must be coupled with frequent wide surgical debridements and intravenous antibiotics for improved outcomes. Various clinical risk factors may render a weakness in the patient's immune status including diabetes mellitus, chronic renal failure, obesity, and autoimmune disorders, such as a human immunodeficiency virus (HIV) infection. Read More

    Status and Challenges of Predicting and Diagnosing Sepsis in Burn Patients.
    Surg Infect (Larchmt) 2018 Jan 12. Epub 2018 Jan 12.
    1 Sunnybrook Research Institute , Toronto, Ontario, Canada .
    Burns are a common form of trauma that account for more than 300,000 deaths each year worldwide. Survival rates have improved over the past decades because of improvements in nutritional and fluid support, burn wound care, and infection control practices. Death, however, remains unacceptably high. Read More

    Membrane-active peptide PV3 efficiently eradicates multidrug-resistant Pseudomonas aeruginosa in a mouse model of burn infection.
    APMIS 2018 Jan 12. Epub 2018 Jan 12.
    Venom and Biotherapeutics Molecules Lab., Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
    The aim of this study was to evaluate the topical bactericidal activity of peptide PV3 against a MDR isolate of Pseudomonas aeruginosa in a mouse model of burn infection. The structural analysis of PV3 by circular dichroism spectroscopy indicated a low peptide helical content in water, whereas a high helical content was observed in the presence of the more hydrophobic 50% (v/v) trifluoroethanol/water buffer. A confocal microscopy analysis indicated that the main action of PV3 occurred at the membrane of bacteria. Read More

    Stem cells therapy: the future in the management of systemic sclerosis? A case report.
    Hell J Nucl Med 2017 Sep-Dec;20 Suppl:164
    Clinic of Plastic, Hand Surgery and Burn Care Unit, University Hospital Schleswig-Holstein, Campus Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.
    Objective: Systemic sclerosis (SSc) is a connective tissue disorder of unknown etiology, with heterogeneous clinical manifestations and chronic and often progressive course. The diffuse cutaneous form of SSc (dcSSc) is characterized by thickening of the skin (scleroderma) and distinctive involvement of multiple internal organs. Patients with limited cutaneous SSc (lcSSc) generally have long-standing Raynaud's phenomenon before other manifestations of SSc appear. Read More

    Vascularization of Lando® dermal scaffold in an acute full-thickness skin-defect porcine model.
    J Plast Surg Hand Surg 2018 Jan 10:1-6. Epub 2018 Jan 10.
    a Department of Burns , Nanfang Hospital, Southern Medical University , Guangzhou , China.
    The Lando® dermal scaffold is a newly developed, tissue-engineered dermal scaffold material. This study sought to observe its vascularization in an acute full-thickness skin-defect porcine model. There were eight Tibetan pigs in this research. Read More

    Biobrane dressing for paediatric burns in Singapore: a retrospective review.
    Singapore Med J 2018 Jan 3. Epub 2018 Jan 3.
    Department of Plastic, Reconstructive and Aesthetic Surgery, KK Women's and Children's Hospital, Singapore.
    Introduction: The ideal burn dressing for children should aim to alleviate pain, decrease length of hospital stay and minimise complications, such as conversion and infection. The current literature is still inconclusive with regard to the gold standard burn dressing for the paediatric population.

    Methods: We retrospectively reviewed children with superficial partial thickness burns admitted to our paediatric burn unit from January 2014 to April 2015. Read More

    Epidemiologic analysis of central vein catheter infection in burn patients.
    Iran J Microbiol 2017 Oct;9(5):271-276
    Burn Research Center, Iran University of Medical Sciences, Motahari Burn Hospital, Tehran, Iran.
    Background And Objectives: Currently, there are no well-defined guidelines or criteria for catheter-site care in burn patients, and there is little information about the epidemiology of central vein catheter (CVC) infection in such patients. This study aimed at addressing the epidemiological aspect of CVC infection in a sample of Iranian burn patients admitted to the largest referral burn center in Iran, Motahari Burn Center.

    Materials And Methods: A total of 191 burn patients were eligible for the study. Read More

    [Wound repair and functional reconstruction of high-voltage electrical burns in wrists].
    Zhonghua Shao Shang Za Zhi 2017 Dec;33(12):738-743
    Department of Burns, Beijing Jishuitan Hospital, Beijing 100035, China.
    Objective: To explore the methods and effects of wound repair and functional reconstruction of high-voltage electrical burns in wrists. Methods: From January 2009 to June 2016, 71 patients with high-voltage electrical burns in wrists were hospitalized, with 118 wrist wounds including 21 of type Ⅰ, 69 of type Ⅱ, 9 of type Ⅲ, and 19 of type Ⅳ. According to the wrist injuries, different surgical operations were performed. Read More

    Diversity of virulence genes in multidrug resistant Pseudomonas aeruginosa isolated from burn wound infections.
    Microb Pathog 2017 Dec 19;115:251-256. Epub 2017 Dec 19.
    Department of Microbiology, Zanjan University of Medical Sciences, Zanjan, Iran.
    Multidrug resistant Pseudomonas aeruginosa has frequently been reported as the cause of nosocomial outbreaks of burn wound infections. The pathogenesis of P. aeruginosa is partly due to the production of several cell-associated and extracellular virulence factors. Read More

    Ethnopharmacological Survey of Medicinal Plants in Albaha Region, Saudi Arabia.
    Pharmacognosy Res 2017 Oct-Dec;9(4):401-407
    Biology, Faculty of Science and Arts, Albaha University, Baljurashi, Albaha, KSA, Yemen.
    Background: Local natural medicinal resource knowledge is important to define and elaborate usage of herbs, in systematic and organized manner. Until recently, there has been little scientifically written document regarding the traditional uses of medicinal plants in Al Bahah region.

    Objective: This pilot study aims to collect the ethnobotanical information from native populations regarding the benefits of medicinal plants of Al Bahah region, and determine if the traditional usage is scientifically established (proved) from literature. Read More

    Consensus on Wound Antisepsis: Update 2018.
    Skin Pharmacol Physiol 2017 Dec 21;31(1):28-58. Epub 2017 Dec 21.
    Institute of Hygiene and Environmental Medicine, University Medicine Greifswald, Greifswald, Germany.
    Wound antisepsis has undergone a renaissance due to the introduction of highly effective wound-compatible antimicrobial agents and the spread of multidrug-resistant organisms (MDROs). However, a strict indication must be set for the application of these agents. An infected or critically colonized wound must be treated antiseptically. Read More

    Prevalence of Monovalent Copper Over Divalent in Killing Escherichia coli and Staphylococcus aureus.
    Curr Microbiol 2017 Dec 19. Epub 2017 Dec 19.
    Sami Shamoon College of Engineering, Beer-Sheva, Israel.
    This study opens the investigation series focused on antimicrobial effects of copper (Cu) compared to silver (Ag), which is currently used to treat wound infection in burn victims as well as in chronic wounds. Noticeably, in its ionized state, Cu is more commonly present as Cu2+ rather than as Cu+, while electronic configuration similarity of Cu+ and Ag+ indicates that actually it may be the active state. To test this hypothesis, effect of Cu+ and Cu2+, using Ag+ ions and metallic copper as controls on Escherichia coli and Staphylococcus aureus bacteria, was examined under anaerobic conditions. Read More

    Surgical burn secondary to the use of alcoholic chlorhexidine.
    Rev Esp Anestesiol Reanim 2017 Dec 14. Epub 2017 Dec 14.
    Sistema Español de Notificación en Seguridad en Anestesia y Reanimación (SENSAR), España. Electronic address:
    Surgical wound infection is one of the main sources of postoperative morbidity/mortality. Skin preparation with an antiseptic agent such as chlorhexidine alcohol solution is an effective method to reduce the incidence of surgical wound infections. Nevertheless, the use of alcohol solutions is associated with some risk as they are inflammable products. Read More

    A 2000 patient retrospective assessment of a new strategy for burn wound management in view of infection prevention and treatment.
    Int Wound J 2017 Dec 15. Epub 2017 Dec 15.
    Dr Stanisław Sakiel Center for Burns Treatment, Siemianowice Śląskie, Poland.
    Infections in burn patients are still the principal cause of complications in burn injuries. The aim of this study is to assess a new strategy for burn wound management in view of infection prevention and treatment in the experience of the Burn Treatment Center in Siemianowice Śląskie. The applied methodology involved the analysis of patient records describing the hospital's epidemiological situation between 2014 and 2016. Read More

    The Use of Keystone Flaps in Periarticular Wound Closure: A Case Series.
    Front Surg 2017 29;4:68. Epub 2017 Nov 29.
    Welsh Centre for Burns and Plastic Surgery, Morriston Hospital, Swansea, United Kingdom.
    The Keystone perforator island flap (Keystone flap), is a Type A fasciocutaneous advancement flap, consisting of two V to Y advancement flaps. Skin cancer excision around joints presents a number of reconstructive challenges. Owing to the mobile nature of joints, the optimal periarticular reconstructive option should possess the ability to provide adequate tissue coverage and withstand regional changes in tensile pressures. Read More

    How much do plastic surgeons add to the closure of myelomeningoceles?
    Childs Nerv Syst 2017 Dec 8. Epub 2017 Dec 8.
    Department of Paediatric Neurosurgery, University Hospital of Wales, Cardiff, UK.
    Purpose: This study reviews the outcomes of children undergoing myelomeningocele (MMC) repair in the paediatric neurosurgical department in Cardiff. These procedures are historically performed by paediatric neurosurgeons with occasional support from plastic surgeons for the larger lesions. We reviewed the postoperative outcomes over a 9-year period to assess the efficacy of having a plastic surgeon present at all MMC closures. Read More

    Open-to-Air Is a Viable Option for Initial Wound Care in Necrotizing Soft Tissue Infection that Allows Early Detection of Recurrence without Need for Painful Dressing Changes or Return to Operating Room.
    Surg Infect (Larchmt) 2018 Jan 6;19(1):65-70. Epub 2017 Dec 6.
    1 Department of Surgery, Texas Tech University Health Sciences Center , School of Medicine, Lubbock, Texas.
    Background: The standard treatment of necrotizing soft tissue infection (NSTI) includes extensive surgical debridement. Care of these debridements is challenging because of the size of the wound and associated pain. A potential solution is to leave the wounds open-to-air in the period after the initial debridement, allowing for regular inspection at bedside while reducing pain associated with frequent dressing changes. Read More

    Therapeutic options and postoperative wound complications after extremity soft tissue sarcoma resection and postoperative external beam radiotherapy.
    Int Wound J 2017 Dec 5. Epub 2017 Dec 5.
    Department of Hand, Plastic, and Reconstructive Surgery, BG Trauma Center Ludwigshafen, University of Heidelberg, Heidelberg, Germany.
    Soft tissue sarcomas occur most commonly in the lower and upper extremities. The standard treatment is limb salvage surgery combined with radiotherapy. Postoperative radiotherapy is associated with wound complications. Read More

    Turbocharged bilateral pedicled DIEP flap for reconstruction of thigh defect without recipient vessels: A case report.
    Microsurgery 2017 Nov 29. Epub 2017 Nov 29.
    Department of Plastic Surgery, Hospital de la Santa Creu i Sant Pau, Universitat Autonóma de Barcelona, Barcelona, Spain.
    Reconstruction of thigh defects is usually straightforward, but in cases of poor soft tissue quality, free flap reconstruction is not possible due to the absence of recipient vessels. The turbocharge technique may increase the viable, vascularized area of a flap. In this report we present a case of the use of a turbocharged bilateral pedicled DIEP flap for reconstruction of thigh defect without recipient vessels. Read More

    Multi-antibiotic resistant extended-spectrum beta-lactamase producing bacteria pose a challenge to the effective treatment of wound and skin infections.
    Pan Afr Med J 2017 30;27:66. Epub 2017 May 30.
    Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
    Introduction: The increasing incidence of antibiotic resistant bacteria is a concern both to the clinicians and the patients due to obvious consequences such as treatment failures, prolonged patients' stay in hospital and nosocomial infections. The choice of the first antibiotic therapy in emergency wards in hospitals is usually not based on patient-specific microbial culture and susceptibility test result.This study is aimed at profiling extended-spectrum beta-lactamase (ESBL) producing bacteria associated with wound injuries and highlighting their multi-antibiotic resistance character. Read More

    Pseudomonas aeruginosa biofilm hampers murine central wound healing by suppression of vascular epithelial growth factor.
    Int Wound J 2017 Nov 27. Epub 2017 Nov 27.
    Department of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
    Biofilm-infected wounds are clinically challenging. Vascular endothelial growth factor and host defence S100A8/A9 are crucial for wound healing but may be suppressed by biofilms. The natural course of Pseudomonas aeruginosa biofilm infection was compared in central and peripheral zones of burn-wounded, infection-susceptible BALB/c mice, which display delayed wound closure compared to C3H/HeN mice. Read More

    Pseudomonas aeruginosa exoproducts determine antibiotic efficacy against Staphylococcus aureus.
    PLoS Biol 2017 Nov 27;15(11):e2003981. Epub 2017 Nov 27.
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, North Carolina, United States of America.
    Chronic coinfections of Staphylococcus aureus and Pseudomonas aeruginosa frequently fail to respond to antibiotic treatment, leading to significant patient morbidity and mortality. Currently, the impact of interspecies interaction on S. aureus antibiotic susceptibility remains poorly understood. Read More

    [Advances in the research of molecular mechanism of negative pressure wound therapy in improving wound healing].
    Zhonghua Shao Shang Za Zhi 2017 Nov;33(11):718-720
    Burn Center of PLA, Department of Burns and Cutaneous Surgery, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.
    Recently, negative pressure wound therapy (NPWT) is a rising technology to improve wound healing. In clinical application, it benefits fast debridement and wound close, limits infection, and promotes wound healing. It is an effective therapy for all kinds of acute or chronic wound. Read More

    A Simplified Derivative of Human Defensin 5 with Potent Efficiency against Multidrug-resistant Acinetobacter baumannii.
    Antimicrob Agents Chemother 2017 Nov 20. Epub 2017 Nov 20.
    State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University
    The increasing incidence of multidrug-resistant Acinetobacter baumannii (MDRAb) infections worldwide has necessitated the development of novel antibiotics. Human defensin 5 (HD5) is an endogenous peptide with a complex architecture and antibacterial activity against MDRAb In the present study, we attempted to simplify the structure of HD5 by removing disulfide bonds. We found that the Cys2-4 bond was most indispensable for HD5 to inactivate MDRAb, although the antibacterial activity of the derivative was significantly attenuated. Read More

    Myxinidin2 and myxinidin3 suppress inflammatory responses through STAT3 and MAPKs to promote wound healing.
    Oncotarget 2017 Oct 15;8(50):87582-87597. Epub 2017 Sep 15.
    Department of Biomedical Science, Chosun University, Gwangju, Korea.
    Skin wounds are continuously exposed to bacteria and can easily become infected. Infected wounds require antibiotic treatment, and infections caused by drug-resistant bacteria are an important public health problem. Antimicrobial peptides have broad-spectrum antibacterial activity, induce little or no drug resistance and may be suitable for treating skin infections caused by drug-resistant bacteria. Read More

    Role of cord blood and bone marrow mesenchymal stem cells in recent deep burn: a case-control prospective study.
    Am J Stem Cells 2017 1;6(3):23-35. Epub 2017 Oct 1.
    Department of Clinical Pathoogy, Cairo UniversityCairo, Egypt.
    Rationale: Burn injuries represent one of the major worldwide public health problems causing more severe physiological stress than other traumas. Effective treatment of burn injuries is mandatory to prevent the numerous life-threatening complications and possible disabilities. Stem cells, a population of multipotent cells retaining the properties of self-renewal and differentiation, are the main player in tissue regeneration after major trauma. Read More

    Dispersion of TiO2 nanoparticles improves burn wound healing and tissue regeneration through specific interaction with blood serum proteins.
    Sci Rep 2017 Nov 13;7(1):15448. Epub 2017 Nov 13.
    Department of Chemistry and Biotechnology, BioCenter, Swedish University of Agricultural Sciences, Box 7015, SE-750 07, Uppsala, Sweden.
    Burn wounds are one of the most important causes of mortality and especially morbidity around the world. Burn wound healing and skin tissue regeneration remain thus one of the most important challenges facing the mankind. In the present study we have addressed this challenge, applying a solution-stabilized dispersion TiO2 nanoparticles, hypothesizing that their ability to adsorb proteins will render them a strong capacity in inducing body fluid coagulation and create a protective hybrid material coating. Read More

    Animal Models for Pseudomonas aeruginosa Quorum Sensing Studies.
    Methods Mol Biol 2018 ;1673:227-241
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    Quorum sensing (QS) systems play global regulatory roles in bacterial virulence. They synchronize the expression of multiple virulence factors and they control and modulate bacterial antibiotic tolerance systems and host defense mechanisms. Therefore, it is important to obtain knowledge about QS modes of action and to test putative therapeutics that may interrupt QS actions in the context of infections. Read More

    Clinical infection in burn patients and its consequences.
    Ulus Travma Acil Cerrahi Derg 2017 Nov;23(6):466-471
    Department of General Surgery, Altınbaş University Faculty of Medicine, İstanbul-Turkey.
    Background: Burn injuries facilitate invasive infections and sepsis not only by destroying the continuity of the protective skin barrier but also through systemic effects. The burn wound, blood, and urine samples are frequently cultured to determine the pathogen agent. The aim of this study was to analyze pathogen growth in patients' cultures confirmed as "infection positive" by the hospital Infection Control Committee and to assess the clinical implications of these growths. Read More

    Phytochemical analysis and antibacterial activity of Gentiana macrophylla extract against bacteria isolated from burn wound infections.
    Microb Pathog 2017 Oct 27;114:25-28. Epub 2017 Oct 27.
    Burn and Plastic Surgery Department, The Third People's Hospital of Wuxi City, Wuxi, 214041, China. Electronic address:
    The management of burn wound victims is often considered a difficult task due to frequent infections. Moreover, the treatment with conventional antibiotics is associated with the upsurge of drug resistant bacterial strains. Therefore there is pressing need to explore antimicrobials that could overcome these problems. Read More

    The Effect of Wound Dressings on a Bio-Engineered Human Dermo-Epidermal Skin Substitute in a Rat Model.
    J Burn Care Res 2017 Nov/Dec;38(6):354-364
    From the *Pediatric Burn Center, Division of Plastic and Reconstructive Surgery, Department of Surgery, University Children's Hospital Zurich, Switzerland; †Children's Research Center, University Children's Hospital Zurich, Switzerland; ‡Tissue Biology Research Unit, Department of Surgery, University Children's Hospital Zurich, Switzerland; and §Department of Surgery, University Children's Hospital Zurich, Switzerland.
    Autologous bio-engineered dermo-epidermal skin substitutes are a promising treatment for large skin defects such as burns. For their successful clinical application, the graft dressing must protect and support the keratinocyte layer and, in many cases, possess antimicrobial properties. However, silver in many antimicrobial dressings may inhibit keratinocyte growth and differentiation. Read More

    Topical antimicrobial agents for pediatric burns.
    Burns Trauma 2017 19;5:33. Epub 2017 Oct 19.
    Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, University of Toronto, Rm D 712, 2075 Bayview Avenue, Toronto, ON M4N 3M5 Canada.
    While topical antimicrobial agents are indicated for most if not all burn wounds, the choice of a topical agent must consider many factors such as the wound depth, anticipated time to healing, need for surgical intervention, and the known cytotoxicity of the agent. Especially relevant to the pediatric burn patient are the antimicrobial agent's properties related to causing pain or irritation and the required frequency of application and dressings. This article will discuss the general principles surrounding the use of topical antimicrobials on burn wounds and will review the most common agents currently in use. Read More

    Development of poly (1,8 octanediol-co-citrate) and poly (acrylic acid) nanofibrous scaffolds for wound healing applications.
    Biomed Mater 2017 Oct 26;13(1):015002. Epub 2017 Oct 26.
    University of Florida, Department of Materials Science and Engineering, 100 Rhines Hall, PO Box 116400, Gainesville, FL 32611, United States of America. University of Florida, Institute for Cell and Tissue Science and Engineering, 300 Weil Hall, PO Box 116550, Gainesville, FL 32611, United States of America.
    Wound care is one of the leading health care problems in the United States costing billions of dollars yearly. Annually, millions of acute wounds occur due to surgical procedures or traumas such as burns and abrasions, and these wounds can become non-healing due to bacterial infection or underlying pathologies. Current wound care treatments include the use of bioinert constructs combined with topical administration of anti-bacterial agents and growth factors. Read More

    Extensive colonization with carbapenemase-producing microorganisms in Romanian burn patients: infectious consequences from the Colectiv fire disaster.
    Eur J Clin Microbiol Infect Dis 2018 Jan 23;37(1):175-183. Epub 2017 Oct 23.
    Department of Medical Microbiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
    Health care of severe burn patients is highly specialized and may require international patient transfer. Burn patients have an increased risk of developing infections. Patients that have been hospitalized in countries where carbapenemase-producing microorganisms (CPMO) are endemic may develop infections that are difficult to treat. Read More

    Toll-Like Receptor Signaling in Burn Wound Healing and Scarring.
    Adv Wound Care (New Rochelle) 2017 Oct;6(10):330-343
    Dental and Craniofacial Trauma Research and Tissue Regeneration Directorate, US Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas.
    Significance: Damage-associated molecular patterns (DAMPs) and pathogen-associated molecular patterns (PAMPs) emanate from burn-injured tissue and enter systemic circulation. Locally and systemically, they activate pattern-recognition receptors, including toll-like receptors (TLRs), to stimulate cytokine secretion, which in the severest burns typically results in extreme systemic cytokine levels, a dysfunctioning immune system, infection, impaired healing, and excessive scarring. This system-wide disruption of homeostasis can advance to life-threatening, multiorgan dysfunction syndrome. Read More

    Heparinase Is Essential for Pseudomonas aeruginosa Virulence during Thermal Injury and Infection.
    Infect Immun 2018 Jan 19;86(1). Epub 2017 Dec 19.
    Department of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    The opportunistic pathogen Pseudomonas aeruginosa is a major cause of sepsis in severely burned patients. If it is not eradicated from the wound, it translocates to the bloodstream, causing sepsis, multiorgan failure, and death. We recently described the P. Read More

    Randomized feasibility trial of replacing or discarding the nail plate after nail-bed repair in children.
    Br J Surg 2017 Nov;104(12):1634-1639
    Department of Plastic Surgery, Imperial College Healthcare NHS Trust, London, UK.
    Background: Nail-bed injuries are the most common hand injury in children. Surgical dogma is to replace the nail plate after repairing the nail bed. Recent evidence suggests this might increase infection rates and returns to clinic. Read More

    Investigating of four main carbapenem-resistance mechanisms in high-level carbapenem resistant Pseudomonas aeruginosa isolated from burn patients.
    J Chin Med Assoc 2017 Oct 9. Epub 2017 Oct 9.
    Department of Microbiology, Guilan University of Medical Sciences, Rasht, Iran.
    Background: Pseudomonas aeruginosa is an opportunistic pathogen involved in many infections. Carbapenem-resistant P.aeruginosa has emerged as an important cause of infection in different hospitals worldwide. Read More

    Eschar removal by bromelain based enzymatic debridement (Nexobrid®) in burns: An European consensus.
    Burns 2017 Dec 13;43(8):1640-1653. Epub 2017 Oct 13.
    BG Trauma Center, Hand-, Plastic and Reconstructive Surgery, Burn Center, University of Heidelberg, Ludwigshafen, Germany.
    Early debridement and/or eschar removal is regarded as a significant step in the treatment of deep partial and full thickness burns. It aims to control wound bioburden and allows early wound closure by conservative treatment or skin grafting. Preservation of viable dermis accompanied by early wound closure, is regarded as a necessary step to reduce scar related complication, e. Read More

    Preparation and evaluation of squid ink polysaccharide-chitosan as a wound-healing sponge.
    Mater Sci Eng C Mater Biol Appl 2018 Jan 18;82:354-362. Epub 2017 Aug 18.
    Faculty of Chemistry and Environment Science, Guangdong Ocean University, Zhanjiang 524088, PR China.
    A new type of wound healing agent was developed using two marine biomaterials (squid ink polysaccharide and chitosan) as carriers and calcium chloride as an initiator for coagulation. Based on central composite design-response surface methodology, comprehensive evaluation of appearance quality for composite sponges and water absorbency were used as evaluation indices to identify the optimized preparation conditions and further evaluate the performance of the squid ink polysaccharide-chitosan sponge (SIP-CS). The optimized formulation of SIP-CS was as follows: chitosan concentration, 2. Read More

    Phenotypic and Molecular Characterization of Multidrug Resistant Klebsiella pneumoniae Isolated from Different Clinical Sources in Al-Najaf Province-Iraq.
    Pak J Biol Sci 2017 ;20(5):217-232
    Department of Microbiology, Faculty of Science, University of Kufa, Kufa, Iraq.
    Background And Objective: Burns infections and urinary tract infections are the most important prevalent diseases in Asian countries, such as Iraq. Klebsiella pneumoniae is one of the most important bacteria cause this type of infections especially in hospitals. Therefore, the aim of this study was to investigate the prevalence of multi-drug resistance K. Read More

    Bacterial infections in burn wound patients at a tertiary teaching hospital in Accra, Ghana.
    Ann Burns Fire Disasters 2017 Jun;30(2):116-120
    Department of Medical Laboratory Science, School of Biomedical and Allied Health Sciences, College of Health Sciences, University of Ghana, Legon, Accra, Ghana.
    Intact human skin surface is essential for protection against infection, preservation of body fluid homeostasis and thermoregulation. Burn injury compromises the skin barrier and enables bacterial infection, hence delaying burn wound healing. This study aimed to determine the microbial profile of burn wounds, and resistance patterns of microbes with respect to the source of the injured patient's wound. Read More

    [Incidence and risk factors for bacteremia on pediatric patients with burns in a specialized care center in Mexico].
    Rev Chilena Infectol 2017 Jun;34(3):221-226
    División de Pediatría, Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Guadalajara, Jalisco, México.
    Background: Bacteremia events are frequent cause of mortality in burn patients and may originate from infected wounds, by bacterial translocation of endogenous microorganisms, from invasive devices or contaminated intravenous solutions.

    Objective: To quantify the incidence of bacteremia in pediatric patients with burns and to identify risk factors.

    Material And Methods: A prospective cohort study was performed in pediatric patients with burns of Hospital Civil de Guadalajara "Dr. Read More

    Optimization and integration of nanosilver on polycaprolactone nanofibrous mesh for bacterial inhibition and wound healing in vitro and in vivo.
    Int J Nanomedicine 2017 12;12:6827-6840. Epub 2017 Sep 12.
    State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, the Third Military Medical University.
    Bacterial infection is a major hurdle to wound healing, and the overuse of antibiotics have led to global issue, such as emergence of multidrug-resistant bacteria, even "super bacteria". On the contrary, nanosilver (NS) can kill bacteria without causing resistant bacterial strains. In this study, NS was simply generated in situ on the polycaprolactone (PCL) nanofibrous mesh using an environmentally benign and mussel-inspired dopamine (DA). Read More

    Effectiveness of a Glycylcycline Antibiotic for Reducing the Pathogenicity of Superantigen-Producing Methicillin-Resistant Staphylococcus aureus in Burn Wounds.
    Eplasty 2017 7;17:e27. Epub 2017 Sep 7.
    The Burn Center, Department of Surgery, MedStar Washington Hospital Center, Washington, DC.
    Objective: Burn-injured patients are highly susceptible to infectious complications, which are often associated with increased morbidity and mortality. Rates of antibiotic resistance have increased, and resistant species such as methicillin-resistant Staphylococcus aureus provide additional challenges in the form of virulence factors. Proteins can disrupt local healing, leading to systemic immune disruption. Read More

    1 OF 92