4,677 results match your criteria Burn Wound Infections


Comparative study of Silver Sulfadiazine with other materials for healing and infection prevention in burns: A systematic review and meta-analysis.

Burns 2018 Jun 11. Epub 2018 Jun 11.

Guarulhos University, Nursing Post, Graduation Program, Praça Tereza Cristina, 88, Centro, Guarulhos, SP, 07020-071, Brazil. Electronic address:

The aim of this systematic review with meta-analysis was to compare the effect of Silver Sulfadiazine (SSD) with other new dressings, with or without silver, on healing and infection prevention in burns. The electronic search was carried out in the electronic databases of Pubmed, ScienceDirect, Lilacs and BVS. The articles included were randomized clinical trials about burn treatment with SSD, which evaluated the healing and infection of burn wounds in humans. Read More

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June 2018
2 Reads

The study of formulated Zoush ointment against wound infection and gene expression of virulence factors Pseudomonas aeruginosa.

BMC Complement Altern Med 2018 Jun 15;18(1):185. Epub 2018 Jun 15.

Department of Microbiology and Applied Microbiology Research Center, Systems Biology and Poisonings Institute and Department Of Microbiology, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Background: The outbreak of MDR and XDR strains of Pseudomonas aeruginosa and increased resistance to infection in burn patients recommend the issue of infection control. In this research, we study ZOUSH herbal ointment for gene silencing of Pseudomonas aeruginosa.

Methods: The herbal ZOUSH ointment was formulated by alcoholic extracts of plants Satureja khuzestaniea, Zataria multiflora, Mentha Mozaffariani Jamzad, honey, and polyurethane. Read More

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Variability in Management of Patients With SJS/TEN: A Survey of Burn Unit Directors.

J Burn Care Res 2018 Jun;39(4):585-592

Internal Medicine Residency Program, Louisiana State University Health Sciences Center, New Orleans.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, type IV hypersensitivity reactions of the skin and mucosa. These reactions (SJS/TEN) are frequently managed in burn units; however, no standardized guidelines exist for the treatment and management of SJS/TEN. To gain insight into current SJS/TEN management practices, a survey on admission, diagnosis, and management, was conducted across accredited burn units in the United States. Read More

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June 2018
2 Reads

The Use of a Silver-Nylon Dressing During Evacuation of Military Burn Casualties.

J Burn Care Res 2018 Jun;39(4):593-597

Uniformed Services University of the Health Sciences, Bethesda, Maryl.

The military has used silver-nylon dressings as a topical antimicrobial on combat-related burns for the past 15 years. However, their clinical efficacy and associated risks have not been evaluated. Herein, the authors document our experience with the use of a specific silver-nylon dressing (Silverlon®) during global evacuation of casualties from combat zones to the United States sArmy Institute of Surgical Research Burn Center. Read More

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June 2018
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Molecular Typing and Carbapenem Resistance Mechanisms of Isolated From a Chinese Burn Center From 2011 to 2016.

Front Microbiol 2018 29;9:1135. Epub 2018 May 29.

State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China.

is the leading cause of infection in burn patients. The increasing carbapenem resistance of has become a serious challenge to clinicians. The present study investigated the molecular typing and carbapenem resistance mechanisms of 196 isolates from the bloodstream and wound surface of patients in our burn center over a period of 6 years. Read More

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Evaluation of Biofilm Formation and Frequency of Multidrug-resistant and Extended Drug-resistant Strain in Isolated from Burn Patients in Isfahan.

Adv Biomed Res 2018 24;7:61. Epub 2018 Apr 24.

Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: is a biofilm-forming bacterium which can result in serious health problems, particularly in burn patients. Biofilm has been assumed to protect the bacteria from environmental fluctuations such as antimicrobial agent. Mucoid strains generate extensive levels of the alginate exopolysaccharide, which is an important factor of its biofilm. Read More

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Correlation of occurrence of infection in burn patients.

Authors:
N A Latifi H Karimi

Ann Burns Fire Disasters 2017 Sep;30(3):172-176

Plastic and Reconstructive Surgery, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.

The study of burn flora is helpful in determining current antibiotic susceptibilities and locating development of multidrug resistant bacterial strains among the unit's usual flora. In this study, we aimed to determine the bacteriological pattern of blood, urine and sputum infections and their correlation with burn wound infections. We used data from our burn registry program. Read More

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September 2017

[Repair of large skin defect of upper limb with abdominal pedicled flap].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2017 Sep;31(9):1102-1105

Department of Burn and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi Guizhou, 563003, P.R.China.

Objective: To investigate the feasibility and effectiveness of designing wide pedicle of abdominal pedicled flap and repairing large skin defect of upper limb with improved suture method.

Methods: Between March 2014 and August 2016, 11 cases with hand and forearm skin soft tissue defect were repaired with abdominal pedicled flaps. Among them, 8 cases were male and 3 were female; aged 18-65 years (mean, 38 years). Read More

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September 2017

Synthesis of graphene oxide-quaternary ammonium nanocomposite with synergistic antibacterial activity to promote infected wound healing.

Burns Trauma 2018 21;6:16. Epub 2018 May 21.

1Institute of Burn Research, State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University, Chongqing, China.

Background: Bacterial infection is one of the most common complications in burn, trauma, and chronic refractory wounds and is an impediment to healing. The frequent occurrence of antimicrobial-resistant bacteria due to irrational application of antibiotics increases treatment cost and mortality. Graphene oxide (GO) has been generally reported to possess high antimicrobial activity against a wide range of bacteria . Read More

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The utilization of an ocular wound chamber on corneal epithelial wounds.

Clin Ophthalmol 2018 14;12:903-911. Epub 2018 May 14.

Department of Sensory Trauma, United States Army Institute of Surgical Research, San Antonio, TX, USA.

Purpose: Currently available ocular moisture chambers are not adequate to manage the treatment of periocular burns, corneal injuries, and infection. The purpose of these studies was to demonstrate that a flexible, semi-transparent ocular wound chamber device adapted from technology currently used on dermal wounds is safe for use on corneal epithelial injuries.

Materials And Methods: A depilatory cream (Nair™, 30 seconds) was utilized to remove the excess hair surrounding the left eyes of anesthetized Institute Armand Frappier (IAF) hairless, female guinea pigs (Crl:HA-Hrhr). Read More

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May 2018
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The Use of Pedicled Perforator Flaps in Chest Reconstruction: A Systematic Review of Outcomes and Reliability.

Ann Plast Surg 2018 May 17. Epub 2018 May 17.

Department of Plastic, Reconstructive and Aesthetic Surgery, South Hospital, University of Rennes 1, Rennes.

Background: In recent years, pedicled perforator flaps have revolutionized plastic surgery by reducing donor site morbidity and ensuring larger and deeper reconstructions with local pedicled cutaneous flaps. The aim of the study was to make a systematic review of perforator pedicled propeller flaps (PPPFs) in chest reconstruction.

Methods: Pubmed and Cochrane databases were searched from 1989 to October 2016 for articles describing the use of PPPFs in chest reconstruction. Read More

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May 2018
1 Read

Treatment of mallet finger deformity with a modified palmaris longus tendon graft through a bone tunnel.

Int J Burns Trauma 2018 5;8(2):34-39. Epub 2018 Apr 5.

Department of Orthopaedics, Southern Medical University, Guangdong No.2 Province People's Hospital Guangdong, China.

Objective: To investigate the clinical effect of treating mallet finger deformity using a modified palmaris longus tendon graft through a bone tunnel.

Methods: Altogether, 21 patients with mallet finger deformity (16 men, 5 women; average age 31 years, range 19-47 years) were treated with a modified palmaris longus tendon graft through a bone tunnel during 18 months (2014-2016). Four index fingers, seven middle fingers, eight ring fingers, and two little fingers were treated for four cutting injuries, eleven finger sprains, four crush injuries, and two twist injuries (7 open and 14 closed injuries). Read More

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Response of a local hospital to a burn disaster: Contributory factors leading to zero mortality outcomes.

Burns 2018 Aug 9;44(5):1083-1090. Epub 2018 May 9.

Department of Surgery, National Taiwan University Hospital, No. 7, Chung Shan South Road, Taipei, Taiwan. Electronic address:

Objective: To investigate the outcomes of a local healthcare system in managing a burn mass casualty incident (BMCI).

Methods: Thirty-three victims admitted to the National Taiwan University Hospital within 96h of the explosion were included in the study. Data were recorded on: patient demographics, Baux score, laboratory data, management response, treatment strategies, and outcomes. Read More

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August 2018
2 Reads

Pyoderma gangrenosum after breast surgery: A systematic review.

J Plast Reconstr Aesthet Surg 2018 Jul 28;71(7):1023-1032. Epub 2018 Mar 28.

Department of Plastic, Reconstructive, Hand and Burn Surgery, Bogenhausen Academic Hospital, Engelschalkingerstr. 77, 81925, Munich, Germany.

Background: Post-surgical pyoderma gangrenosum (PSPG) is a rare inflammatory skin disorder of unknown aetiology. Given its similar presentation to wound infection and lack of reliable diagnostic tests as well as pathognomonic clinical features, PSPG is difficult to diagnose. The aim of this review was to identify factors contributing to PSPG to aid with timely diagnosis and appropriate therapy. Read More

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July 2018
1 Read

Effect of nano-silver hydrogel coating film on deep partial thickness scald model of rabbit.

Saudi J Biol Sci 2018 May 19;25(4):797-800. Epub 2017 Sep 19.

Department of Pharmacology, Henan University of Chinese Medicine, Zhengzhou 450046, China.

Objective: Observing the effect of nano-silver hydrogel coating film on deep partial thickness scald model of rabbit.

Method: We prepared boiling water scalded rabbits with deep II degree scald models and applied high, medium and low doses of nano-silver hydrogel coating film for different time and area. Then we compared the difference of burned paper weight before administration and after administration model burns, burn local skin irritation points infection, skin crusting and scabs from the time, and the impact of local skin tissue morphology. Read More

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An Ointment Consisting of the Phage Lysin LysGH15 and Apigenin for Decolonization of Methicillin-Resistant from Skin Wounds.

Viruses 2018 05 6;10(5). Epub 2018 May 6.

Key Laboratory of Zoonosis Research, Ministry of Education, College of Veterinary Medicine, Jilin University, Xi'an Road 5333#, Changchun 130062, China.

() is a common and dangerous pathogen that causes various infectious diseases. Skin damage, such as burn wounds, are at high risk of colonization and infection, which increases morbidity and mortality. The phage lysin LysGH15 exhibits highly efficient lytic activity against methicillin-resistant (MRSA) and methicillin-susceptible (MSSA) strains. Read More

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Predictive modelling of a novel anti-adhesion therapy to combat bacterial colonisation of burn wounds.

PLoS Comput Biol 2018 05 3;14(5):e1006071. Epub 2018 May 3.

School of Mathematics, University of Birmingham, Edgbaston, Birmingham, United Kingdom.

As the development of new classes of antibiotics slows, bacterial resistance to existing antibiotics is becoming an increasing problem. A potential solution is to develop treatment strategies with an alternative mode of action. We consider one such strategy: anti-adhesion therapy. Read More

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A Rare Case of Cutaneous Diffuse Large B-cell Lymphoma Presenting as a Chronic "Infectious" Skin Ulcer.

Ostomy Wound Manage 2018 Apr;64(4):44-47

State Key Laboratory of Trauma, Burns, and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University, Chongqing, China.

Cutaneous diffuse large B-cell lymphoma (DLBCL) usually manifests as papules, nodules, or plaques. A rare case of a patient with a chronic skin ulcer and signs and symptoms of infection, including fever and large amounts of yellow wound exudate, is presented. Fifteen (15) months before diagnosis, a 43-year-old otherwise healthy man noted soreness without apparent cause in his upper chest and a palpable 2 cm x 2 cm focal lump. Read More

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Thoracoumbilical Flap: Anatomy, Technique, and Clinical Applications in Upper Limb Reconstruction in the Era of Microvascular Surgery.

J Hand Microsurg 2018 Apr 20;10(1):29-36. Epub 2018 Mar 20.

Department of Plastic Reconstructive and Burns Surgery, All India Institute of Medical Sciences, New Delhi, India.

Purpose: Microvascular reconstruction is the standard of care for salvage of soft tissue defects in complex upper extremity due to their distinct advantages over the pedicled flaps. However, in the era of microsurgery, pedicled flaps have an acceptable significant role for reconstruction of complex soft tissue defects. The authors aim to demonstrate the versatility of pedicled thoracoumbilical flap (TUF) in selected clinical scenarios. Read More

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Outbreak of Invasive Wound Mucormycosis in a Burn Unit Due to Multiple Strains of Mucor circinelloides f. circinelloides Resolved by Whole-Genome Sequencing.

MBio 2018 Apr 24;9(2). Epub 2018 Apr 24.

Institut Pasteur, National Reference Center for Invasive Mycoses and Antifungals (NRCMA), Molecular Mycology Unit, Paris, France

Mucorales are ubiquitous environmental molds responsible for mucormycosis in diabetic, immunocompromised, and severely burned patients. Small outbreaks of invasive wound mucormycosis (IWM) have already been reported in burn units without extensive microbiological investigations. We faced an outbreak of IWM in our center and investigated the clinical isolates with whole-genome sequencing (WGS) analysis. Read More

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[Antiseptic effect of compound lysostaphin disinfectant and its preventive effect on infection of artificial dermis after graft on full-thickness skin defect wound in rats].

Zhonghua Shao Shang Za Zhi 2018 Apr;34(4):225-232

Burn Institute of PLA, Department of Burn Surgery, the First Affiliated Hospital, Naval Military Medical University, Shanghai 200433, China.

To study the antiseptic effect of compound lysostaphin disinfectant and its preventive effect on infection of artificial dermis after graft on full-thickness skin defect wound in rats. (1) Each one standard strain of and were selected. Each 20 clinical strains of and were collected from those isolated from wound exudates of burn patients hospitalized in our wards from January 2014 to December 2016 according to the random number table. Read More

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April 2018
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Candida tropicalis burn wound sepsis: A series of histopathology-confirmed cases.

Intensive Crit Care Nurs 2018 Jun 16;46:6-9. Epub 2018 Apr 16.

Department of Burn and Plastic Surgery, Jinan Central Hospital Affiliated to Shandong University, PR China.

Fungal infection in severely burned patients is a serious problem due to various factors, such as the extensive application of antibiotics. In this study, we report on the course of severely burned patients with Candida tropicalis burn wound sepsis. Five such cases were reviewed. Read More

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June 2018
1 Read

Selective Fiber Degeneration in the Peripheral Nerve of a Patient With Severe Complex Regional Pain Syndrome.

Front Neurosci 2018 4;12:207. Epub 2018 Apr 4.

Department of Plastic Surgery & Burns, Manchester Academic Health Science Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, United Kingdom.

Complex regional pain syndrome (CRPS) is characterized by chronic debilitating pain disproportional to the inciting event and accompanied by motor, sensory, and autonomic disturbances. The pathophysiology of CRPS remains elusive. An exceptional case of severe CRPS leading to forearm amputation provided the opportunity to examine nerve histopathological features of the peripheral nerves. Read More

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Efficacy of a Gel Containing Polihexanide and Betaine in Deep Partial and Full Thickness Burns Requiring Split-thickness Skin Grafts: A Noncomparative Clinical Study.

J Burn Care Res 2018 May 17. Epub 2018 May 17.

Department of Plastic and Hand Surgery, University Center for Orthopedics and Trauma Surgery, Universitätsklinikum Carl Gustav Carus Dresden, Germany.

Despite overall advances in burn therapy, wound infection remains one of the leading causes of morbidity and mortality in patients with severe burn injuries. This prospective, multicenter, noncomparative clinical trial was conducted to assess the efficacy and safety of Prontosan® Wound Gel X (PWX), a gel containing polihexanide and betaine, for moistening and cleansing in deep tissue burn wounds requiring split-thickness skin grafting. Patients with deep partial or full thickness burn wounds requiring split-thickness skin grafting were treated with the gel to evaluate its tolerability and safety as well as graft take and the healing of the skin graft. Read More

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May 2018
2 Reads

Lectin-Functionalized Composite Hydrogels for "Capture-and-Killing" of Carbapenem-Resistant Pseudomonas aeruginosa.

Biomacromolecules 2018 Apr 25. Epub 2018 Apr 25.

Center for Peptide Pharmaceuticals, Faculty of Natural Science , Ulm University , 89081 Ulm , Germany.

Infections with multiresistant pathogens are a leading cause for mortality worldwide. Just recently, the World Health Organization (WHO) increased the threat rating for multiresistant Pseudomonas aeruginosa to the highest possible level. With this background, it is crucial to develop novel materials and procedures in the fight against multiresistant pathogens. Read More

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April 2018
7 Reads

Development of a contaminated ischemic porcine wound model and the evaluation of bromelain based enzymatic debridement.

Burns 2018 Jun 13;44(4):896-904. Epub 2018 Apr 13.

Mediwound Ltd., Yavneh, Israel; Department of Plastic and Reconstructive Surgery, Ben Gurion University, Beer-Sheba, Israel.

Objectives: There are no well accepted animal models of chronic wounds, limiting advances in understanding and treatment of chronic ulcers. We developed a porcine wound model which combines multiple factors involved in chronic wounds to create a contaminated necrotic eschar and evaluated the debriding efficacy of a novel bromelain based enzymatic debriding agent (EscharEx).

Methods: Contaminated ischemic wounds were created on the flanks of domestic pigs by 'sandwiching' the skin between 2 'O' rings (1 placed on the surface of the skin and the other underneath the skin) for 24h prior to dermatomal excision of the necrotic eschar and its contamination with Staphylococcus aureus and Candida albicans. Read More

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June 2018
3 Reads

Traditional culture methods fail to detect principle pathogens in necrotising soft tissue infection: a case report.

J Wound Care 2018 Apr;27(Sup4):S24-S28

Department of Surgery, Texas Tech University Health Sciences Center, TTUHSC Burn Center of Research Excellence, Texas Tech University Health Sciences Center.

Objective: Necrotising soft tissue infections (NSTIs) progress rapidly and mortality remains high, ranging from 10% to 30%, representing a significant challenge for health professionals. Early accurate diagnosis is crucial because timely and aggressive surgical intervention remains the number one indicator for a better clinical outcome. Understanding the microbial background of NSTIs would aid early diagnosis. Read More

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April 2018
3 Reads

Impact of anaemia on outcome in burn patients.

Anaesthesiol Intensive Ther 2018 ;50(1):11-19

Department of Anesthesiology, University of Florida College of Medicine.

Background: Currently, most critical care physicians maintain a patient's haemoglobin levels at 7 to 8 g dL-1. However, little data have been available on haemoglobin-related outcomes in burn patients. The purpose of this study was to evaluate inpatients with greater than 20% total body surface area burns and the effects of haemoglobin below 8 g dL-1 on clinical outcomes. Read More

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January 2018

Autofluorescence Imaging for Evaluating Debridement in Military and Trauma Wounds.

Mil Med 2018 Mar;183(suppl_1):429-432

Birmingham Burn Centre, The Queen Elizabeth Hospital, Mindelsohn Way, Birmingham, B15 2TH, UK.

Background: Mechanisms for military injury have evolved in the past century. Debridement is the gold standard for preparing a clean wound bed, decreasing the bacterial load, and reducing the likelihood of infection. However, bacteria may continue to linger in these wounds. Read More

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Treatment of toxic epidermal necrolysis by a multidisciplinary team. A review of literature and treatment results.

Burns 2018 Jun 4;44(4):807-815. Epub 2018 Apr 4.

Department of Dermatology and Skin Science, University of British Columbia, Canada.

Background: Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are mucocutaneous hypersensitivity reactions, usually to drugs or their metabolites. TEN is the most severe involving greater than 30% of the total body surface area (TBSA). Management of these patients usually benefits from a large multidisciplinary team for both wound and medical management. Read More

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June 2018
2 Reads

Sternal Reconstruction with the Omental Flap-Acute and Late Complications, Predictors of Mortality, and Quality of Life.

J Reconstr Microsurg 2018 Jun 6;34(5):376-382. Epub 2018 Apr 6.

Department of Hand-, Plastic, Reconstructive and Burn Surgery, BG Trauma Center Tuebingen, Eberhard Karls University, Tuebingen, Germany.

Background:  The omental flap is a reliable flap for the coverage of sternal defects. However, little is known about the predictors of mortality and the long-term outcome in such patients.

Methods:  We, therefore, performed a retrospective study from 2002 to 2013, including all patients who underwent sternal reconstruction with the omental flap. Read More

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June 2018
1 Read

L. inermis-loaded nanofibrous scaffolds for wound dressing applications.

Tissue Cell 2018 Apr 21;51:32-38. Epub 2018 Feb 21.

Department of Hematology, Faculty of Medical Sciences, Tarbiat Modarres University, Tehran, 14115-111, Iran. Electronic address:

Since ancient times, some herbal medicines have been extensively used for burn and wound treatments, showing preference to the common synthetic medications by virtue of having less side effects and faster healing rate. In this study, hybrid nanofibrous scaffolds of poly-l-lactic-acid (PLLA) and gelatin incorporated L. inermis were fabricated via electrospinning technique. Read More

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Acetic acid dressings: Finding the Holy Grail for infected wound management.

Indian J Plast Surg 2017 Sep-Dec;50(3):273-280

Department of Microbiology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.

Background: Wounds have since long, contributed majorly to the health-care burden. Infected long-standing non-healing wounds place many demands on the treating surgeon and are devastating for the patients physically, nutritionally, vocationally, financially, psychologically and socially. Acetic acid has long been included among agents used in the treatment of infected wounds. Read More

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Staphylopine, pseudopaline, and yersinopine dehydrogenases: A structural and kinetic analysis of a new functional class of opine dehydrogenase.

J Biol Chem 2018 May 4;293(21):8009-8019. Epub 2018 Apr 4.

From the Departments of Molecular Biosciences and

Opine dehydrogenases (ODHs) from the bacterial pathogens , , and perform the final enzymatic step in the biosynthesis of a new class of opine metallophores, which includes staphylopine, pseudopaline, and yersinopine, respectively. Growing evidence indicates an important role for this pathway in metal acquisition and virulence, including in lung and burn-wound infections () and in blood and heart infections (). Here, we present kinetic and structural characterizations of these three opine dehydrogenases. Read More

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[Advances in the research of relationship between brown or beige fat and hypermetabolism after severe burn].

Authors:
M Zhang Y Liu X Zhang

Zhonghua Shao Shang Za Zhi 2018 Mar;34(3):178-182

Department of Burns and Plastic Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.

Hypermetabolism is one of the remarkable characteristics of burn injury. Prolonged hypermetabolism causes insufficient energy supply, which leads to delayed wound healing, immune system dysfunction, increased infection rate, and multi-organ failure. In recent years, it is concerned that the activation of brown or beige adipose tissue may be related to hypermetabolism in severe burn patients. Read More

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Original and modified technique of tie-over dressing: Method and application in burn patients.

Burns 2018 Aug 27;44(5):1357-1360. Epub 2018 Mar 27.

Department of Burn Care, Saint-louis Hospital, 1, Avenue Claude Vellefaux, 75010 Paris, France.

In burn patients, meshed split thickness skin grafts are commonly used on large and non-flat areas whom immobilization is difficult to achieve. The frequent mobilizations of burn patients can make the graft slip and prevent the revascularization and therefore the taking of the skin graft. In order to prevent this pitfall, we modified and adapted the tie-over dressing procedure. Read More

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August 2018
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Draft Genome Sequence of an NDM-1- and KPC-2-Coproducing Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Strain Isolated from Burn Wound Infections.

Genome Announc 2018 Mar 29;6(13). Epub 2018 Mar 29.

Department of Bacteriology, First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, People's Republic of China

We report here the draft genome sequence of an NDM-1- and KPC-2-coproducing hypervirulent carbapenem-resistant strain, isolated from a 58-year-old male in the People's Republic of China with a burn injury. Read More

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March 2018
1 Read

The Role of Serotonin during Skin Healing in Post-Thermal Injury.

Int J Mol Sci 2018 Mar 29;19(4). Epub 2018 Mar 29.

Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.

Post-burn trauma significantly raises tissue serotonin concentration at the initial stages of injury, which leads us to investigate its possible role in post burn wound healing. Therefore, we planned this study to examine the role of serotonin in wound healing through in vitro and in vivo models of burn injuries. Results from in vitro analysis revealed that serotonin decreased apoptosis and increased cell survival significantly in human fibroblasts and neonatal keratinocytes. Read More

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March 2018
1 Read

Treatment of partial thickness hand burn injuries in children with combination of silver foam dressing and zinc-hyaluronic gel: Case reports.

Medicine (Baltimore) 2018 Mar;97(13):e9991

Department of Paediatrics, Surgical Division.

Rationale: Burns is a common type of traumatic injury in childhood. Nowadays, several wound dressings are available to treat the second-degree hand burns conservatively.

Patient Concerns, Diagnoses: At the authors' institute, 37 children were treated conservatively with a special dressing at first intervention containing Aquacel Ag foam and Zn-hyaluronic gel to determine their effectiveness on partial thickness hand burns. Read More

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Comamonas kerstersii bacteremia in a patient with acute perforated appendicitis: A rare case report.

Medicine (Baltimore) 2018 Mar;97(13):e9296

Department of Burns and Wound Repair Surgery.

Rationale: Comamonas species are rarely associated with human infections. Recent reports found that Comamonas kerstersii was associated with severe diseases such as abdominal infection and bacteremia. However, C. Read More

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Burn aggravated infected wart in a patient with type 2 diabetes: a medical challenge.

BMJ Case Rep 2018 Mar 28;2018. Epub 2018 Mar 28.

Department of Pharmaceutics, Hamdard University, Karachi, Pakistan.

An infectious wart of foot in a patient with diabetics is a medical challenge, and it gets worse when aggravated with burns. We present a case of a 67-year-old Pakistani man, diabetic for 20 years presented at our healthcare centre. While awaiting his culture sensitivity report, he was prescribed an empiric antibiotic therapy. Read More

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March 2018
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Clinical characteristics of infectious ulceration over tophi in patients with gout.

J Int Med Res 2018 Jun 27;46(6):2258-2264. Epub 2018 Mar 27.

3 Department of Orthopedics, Wenzhou Central Hospital, Wenzhou 325000, China.

Objective The aim of this study was to investigate the clinical characteristics of infectious ulceration over tophi in patients with gout. Methods Participants were recruited from the First Affiliated Hospital of Wenzhou Medical University. The clinical characteristics of the patients and wound characteristics were recorded. Read More

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June 2018
1 Read

Optimizing mass casualty burns intensive care organization and treatment using evidence-based outcome predictors.

Burns 2018 Aug 19;44(5):1077-1082. Epub 2018 Mar 19.

Department of Nephrology, Kidney Research Center, Linkou Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan. Electronic address:

Background: Majority of current research focuses on pre-hospital care in mass casualty incidents (MCI) whereas this study is the first to examine multifactorial aspects of intensive care unit (ICU) resource management during a surge in massive burn injury (MBI) patients whilst identifying key outcome predictors that resulted in successful disaster managements.

Methods: Both critical care, surgical parameters and cost-effectiveness are investigated in patients admitted with severe burns resulting from the explosion. A fully integrated trauma response and expansion of critical care resources in Linkou Chang Gung Memorial Hospital (CGMH) in this incident is analyzed. Read More

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August 2018
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Expert Outpatient Burn Care in the Home through Mobile Health Technology.

J Burn Care Res 2018 Mar 17. Epub 2018 Mar 17.

Division of Pediatric Surgery, Department of Surgery, Medical University of South Carolina, Charleston, South Carolina.

Access to care for pediatric burns remains a major public health problem in the US. Telemedicine has an opportunity to improve access to care, but current models are expensive and inefficient. We have developed and pilot-tested the TeleBurn App, a novel smartphone application, to treat partial thickness burns while outpatient. Read More

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Evaluation of Glandular Liposculpture as a Single Treatment for Grades I and II Gynaecomastia.

Aesthetic Plast Surg 2018 Mar 16. Epub 2018 Mar 16.

Department of Hand and Plastic Surgery, Burn Centre, Linköping University Hospital, 58185, Linköping, Sweden.

Background: Gynaecomastia is a benign enlargement of the male breast, of which the psychological burden on the patient can be considerable, with the increased risk of disorders such as depression, anxiety, and social phobia. Minimal scarring can be achieved by liposuction alone, though it is known to have a limited effect on the dense glandular and fibroconnective tissues. We know of few studies published on "liposuction alone", so we designed this study to evaluate the outcome of combining liposuction with glandular liposculpturing through two axillary incisions as a single treatment for the management of grades I and II gynaecomastia. Read More

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March 2018
4 Reads

An efficient antimicrobial depot for infectious site-targeted chemo-photothermal therapy.

J Nanobiotechnology 2018 Mar 16;16(1):23. Epub 2018 Mar 16.

Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China.

Background: Silver and photothermal therapy (PTT) have been widely used for eradicating the drug-resistant bacteria. However, the risks of excess of silver for humans and the low efficiency of PTT still limit their in vivo therapeutic application. Integration of two distinctive bactericides into one entity is a promising platform to improve the efficiency of antimicrobial agents. Read More

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March 2018
3 Reads

Transcriptome Analysis of Cultured in Human Burn Wound Exudates.

Front Cell Infect Microbiol 2018 27;8:39. Epub 2018 Feb 27.

Microbiology Unit, Department of Botany and Plant Biology, Sciences III, University of Geneva, Geneva, Switzerland.

is a severe opportunistic pathogen and is one of the major causes of hard to treat burn wound infections. Herein we have used an RNA-seq transcriptomic approach to study the behavior of PAO1 growing directly on human burn wound exudate. A chemical analysis of compounds used by this bacterium, coupled with kinetics expression of central genes has allowed us to obtain a global view of physiological and metabolic changes occurring while growing on human burn wound exudate. Read More

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February 2018

[Chinese expert consensus on tetanus immunization].

Authors:

Zhonghua Wai Ke Za Zhi 2018 Mar;56(3):161-167

Tetanus is an acute specific infection caused by obligate anaerobes, which is still a serious public health problem. Tetanus bacterium is an obligate anaerobic bacterium, widely distributed in nature, which can exist in dust, soil, human or animal excrement. The bacteria invade the body primarily through the skin or mucosal wounds, and most commonly in trauma and burn patients, unclean newborns, and unsafe surgical instruments. Read More

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March 2018
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Immunoproteasome in the Plasma of Paediatric Patients with Moderate and Major Burns, and its Correlation with Proteasome and UCHL1 Measured by SPR Imaging Biosensors.

J Burn Care Res 2018 Mar 9. Epub 2018 Mar 9.

Paediatric Surgery Department Medical University of Bialystok, Poland.

The Aim: to determinate the immunoproteasome concentration in blood plasma of paediatric patients with moderate and major burns, and its correlation with circulating proteasome and UCHL1 with SPRI biosensor.

Material And Methods: The study population comprised 30 patients with moderate (n=21), and severe burns (n=9), aged 9 months to 14 years. The control group represented 18 healthy, age matched patients, admitted for herniotomy. Read More

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Biogenic synthesis of copper nanoparticles by natural polysaccharides and Pleurotus ostreatus fermented fenugreek using gamma rays with antioxidant and antimicrobial potential towards some wound pathogens.

Microb Pathog 2018 May 9;118:159-169. Epub 2018 Mar 9.

Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt. Electronic address:

Mono-dispersed copper nanoparticles (CuNPs) were constructed using cheap polysaccharides (citrus pectin, chitosan, and sodium alginate), and by appropriating aqueous fermented fenugreek powder (FFP) under the action of Pleurotus ostreatus (as reducing and preserving means), through the influence of gamma irradiation. The synthesized CuNPs are described by UV-Vis. spectroscopy TEM, DLS, XRD, and FT-IR. Read More

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May 2018
3 Reads