4,842 results match your criteria Burn Wound Infections


The role of collagenase ointment in acute burns: a systematic review and meta-analysis.

J Wound Care 2019 Feb;28(Sup2):S9-S15

Assistant Professor; Keck School of Medicine, University of Southern California, Los Angeles, US. Division of Plastic Surgery, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, US.

Objective:: A systematic review and meta-analysis was performed to summarise the state of the literature in regard to the efficacy and uses of clostridial collagenase ointment (CCO) in the burn patient.

Method:: A systematic review of articles available on PubMed, Scopus and OvidSP Medline was performed. Keywords used in the search process included burns, thermal injury, collagenase, enzymatic debridement, wound care. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12968/jowc.2019.28.Sup2.S9DOI Listing
February 2019

Carbapenem-resistant Acinetobacter baumannii isolates carrying the blaOXA genes with an upstream ISAba1: The first report of a novel OXA subclass from Iran.

J Glob Antimicrob Resist 2019 Feb 11. Epub 2019 Feb 11.

Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran; Department of Microbiology, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran. Electronic address:

Objectives: Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a serious challenge and poses a threat to public health worldwide. This study aimed to determine drug susceptibility of A. baumannii, and then, investigate oxacillinase-encoding determinants and their association with ISAba1 sequence in CRAB isolates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jgar.2018.12.011DOI Listing
February 2019

[Imaging of bacteria in burn wounds treated with split-thicknessgrafts in MEEK/MESH technique: a pilot study with first experiences in clinical wound evaluation with autofluorescence].

Handchir Mikrochir Plast Chir 2019 Feb 12. Epub 2019 Feb 12.

Medizinische Hochschule Hannover, Klinik für Plastische, Ästhetische, Hand- und Wiederherstellungschirurgie, Replantationszentrum Niedersachsen, Schwerbrandverletztenzentrum Niedersachsen.

Background: Partial and full thickness burns require surgical treatment, such as early débridement and skin transplantation in MEEK/MESH technique or further reconstructive surgery. Infections of burns or transplanted areas limit surgical success and increase patient mortality. For split-thickness grafts in MEEK technique a superficial silk is applied as a protective on-top dressing, whereas in MESH technique fatty gauze and foam are used as standard protective covers over five to seven days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0584-7488DOI Listing
February 2019
1 Read

[Application of high frequency color Doppler ultrasound combined with wide-field imaging in the preoperative navigation of anterolateral thigh perforator flap surgery].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2019 Feb;33(2):190-194

Department of Burn and Plastic Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi Guizhou, 563000, P.R.China.

Objective: To investigate the application of high frequency color Doppler ultrasound (HFCDU) combined with wide-field imaging in the preoperative navigation of anterolateral thigh perforator flap graft.

Methods: Between January 2017 and March 2018, 28 patients with skin and soft tissue defects were treated, including 22 males and 6 females, with an average age of 33.5 years (range, 17-66 years). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7507/1002-1892.201810025DOI Listing
February 2019
1 Read

Plasmid-Mediated Quinolone Resistance in Pseudomonas aeruginosa Isolated from Burn Patients in Tehran, Iran.

Infect Disord Drug Targets 2019 Feb 6. Epub 2019 Feb 6.

Student Research Committee, Qazvin University of Medical Sciences, Qazvin. Iran.

Introduction: Plasmid-induced quinolone resistance has raised a great concern in the treatment of serious infections worldwide. The aims of this study were to determine the antibiotic susceptibility, the frequency of qepA, aac(6')-Ib, and qnr genes by PCR and sequencing, and typing of the resistant isolates using repetitive extragenic palindromic sequence-based PCR (REP-PCR) in Pseudomonas aeruginosa isolated from burn wound infections.

Material And Methods: In the current cross-sectional study, 149 P. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2174/1871526519666190206205521DOI Listing
February 2019
12 Reads

Outcomes of the Use of Hyaluronic Acid-Based Wound Dressings for the Treatment of Partial-Thickness Facial Burns.

J Burn Care Res 2019 Feb 2. Epub 2019 Feb 2.

Faculty of Medicine, Department of General Surgery, Karadeniz Technical University, Trabzon, Turkey.

The purpose of this study was to assess clinical, functional and cosmetic outcomes of the use of hyaluronic acid-based wound dressings for partial-thickness facial burns. Patients with partial-thickness facial burns hospitalized at the Burn Center between April 2014 and April 2017 were evaluated. Data pertaining to demographic characteristics, etiology, and degree of burn and percentage of burn to TBSA were collected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jbcr/irz004DOI Listing
February 2019

Oropharyngeal, Hypopharyngeal and Cervical Esophageal Reconstruction: An Experience of Pedicle Flaps.

J Coll Physicians Surg Pak 2019 Feb;29(2):168-172

Department of Plastic Surgery, Jinnah Burn and Reconstructive Surgery Center / Allama Iqbal Medical College, Lahore, Pakistan.

Objective: To review the experience of single-stage reconstruction following pharygolaryngectomy and cervical esophageal defect with pedicle flaps in a tertiary care centre.

Study Design: Retrospective study.

Place And Duration Of Study: Jinnah Burn and Reconstructive Surgery Centre, Lahore, from June 2007 to June 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.29271/jcpsp.2019.02.168DOI Listing
February 2019

Antimicrobial susceptibility and virulence genes of clinical and environmental isolates of .

PeerJ 2019 22;7:e6217. Epub 2019 Jan 22.

Department of Biomedical Science, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Background: is ubiquitous, has intrinsic antibiotic resistance mechanisms, and is associated with serious hospital-associated infections. It has evolved from being a burn wound infection into a major nosocomial threat. In this study, we compared and correlated the antimicrobial resistance, virulence traits and clonal relatedness between clinical and fresh water environmental isolates of . Read More

View Article

Download full-text PDF

Source
https://peerj.com/articles/6217
Publisher Site
http://dx.doi.org/10.7717/peerj.6217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346980PMC
January 2019
5 Reads

Herpes simplex virus infection in minor burn injury: a case report.

Int J Burns Trauma 2018 20;8(6):149-152. Epub 2018 Dec 20.

Pediatrician, Burn Research Center, Iran University of Medical Sciences Tehran, Iran.

This is a relative rare case of 0.5% TBSA (total body surface area) burn wound infection caused by Herpes Simplex Virus (HSV). A 1-year-old male infant had deep second degree burn of the left fourth finger with 0. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334217PMC
December 2018
1 Read

The diathermy scratch pad: A cheap and efficient tool for chemical and explosion-related burns.

Arch Plast Surg 2019 Jan 15;46(1):88-91. Epub 2019 Jan 15.

Plastic, Reconstructive and Aesthetic Surgery Service, Sengkang General Hospital, Singapore.

The burn center in our hospital is a national and regional (Southeast Asia) center. Of all admissions, 10% are related to blast explosions, and 8% due to chemical burns. In the acute burn management protocol of Singapore General Hospital, early surgical debridement is advocated for all acute partial-thickness burns. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5999/aps.2018.00507DOI Listing
January 2019
1 Read

Tissue expanders; review of indications, results and outcome during 15 years' experience.

Burns 2019 Jan 23. Epub 2019 Jan 23.

Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: Tissue expanders (TE) are frequently used worldwide. In this study we surveyed outcome of our patients retrospectively during 15 years.

Materials And Methods: We had 1105 patients for whom 3059 TEs have been used. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.burns.2018.11.017DOI Listing
January 2019
1 Read

The effect of antimicrobial photodynamic therapy on the expression of biofilm associated genes in Staphylococcus aureus strains isolated from wound infections in burn patients.

Photodiagnosis Photodyn Ther 2019 Jan 23. Epub 2019 Jan 23.

Oral Microbiology Laboratory, Department of Microbiology, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Purpose: Burn patients are particularly susceptible to microbial infection. Staphylococcus aureus causes burn wound, impetigo and cellulitis. Although sub-lethal antimicrobial photodynamic therapy (aPDT) would not result in microorganism killing, it can considerably influence microbial virulence factor. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.pdpdt.2019.01.028DOI Listing
January 2019
2 Reads

[Effects of free superficial temporal fascia flaps and skin grafts in repairing deep wounds in posterior ankle region of extensively burned patients].

Zhonghua Shao Shang Za Zhi 2019 Jan;35(1):62-64

Department of Burns and Cutaneous Surgery, Burn Center of PLA, Xijing Hospital, Air Force Medical University, Xi'an 710032, China.

To observe the effects of the method of combining free superficial temporal fascia flaps with skin grafts in repairing deep wounds in posterior ankle region of extensively burned patients. From September 2013 to February 2017, 11 extensively burned patients with deep tissue defects in posterior ankle region were treated in our unit. Two patients had tissue defects in bilateral posterior ankle regions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.1009-2587.2019.01.011DOI Listing
January 2019
1 Read

[Developing trend of wound dressing].

Authors:
J N Huan

Zhonghua Shao Shang Za Zhi 2019 Jan;35(1):8-11

Department of Burns and Plastic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

The ideal wound dressing should have the functions of keeping wound moist and warm, preventing and treating wound infection, promoting wound healing, and so on; However there is no such ideal wound dressing in clinic. Dressings are likely to capable application to different kinds of wounds with multi-functions in the future. For the purpose of good tissue compatibility and permanent wound cover, auto- or allo- skin living cells should be integrated with biological dressings as real artificial skin by employing tissue engineering technology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.1009-2587.2019.01.003DOI Listing
January 2019

Burn injury and blood transfusion.

Authors:
Tina L Palmieri

Curr Opin Anaesthesiol 2019 Jan 22. Epub 2019 Jan 22.

Shriners Hospital for Children Northern California.

Purpose Of Review: Blood transfusion is ubiquitous in major burn injury. The present article describes recent research findings directly impacting blood transfusion strategies in major burn injury both in the operating room and the ICU.

Recent Findings: Transfusion strategies have been the focus of recent burn investigations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ACO.0000000000000701DOI Listing
January 2019
2 Reads

Infection Prevention: Unique Aspects of Burn Units.

Authors:
Tina L Palmieri

Surg Infect (Larchmt) 2019 Jan 24. Epub 2019 Jan 24.

1 Shriners Hospital for Children Northern California, Sacramento, California.

Background: Infection is a common complication of burn injury caused by the loss of skin (the primary defense against micro-organisms) as well as burn-induced immunosuppression. Essentially, survival after burn injury is determined by whether wound healing or infection predominates. The purpose of this article is to describe how burn unit structure and design may impact the incidence of infection after burn injury. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/sur.2018.301DOI Listing
January 2019
1 Read

Flaminal® versus Flamazine® in the treatment of partial thickness burns: A randomized controlled trial on clinical effectiveness and scar quality (FLAM study).

Wound Repair Regen 2019 Jan 24. Epub 2019 Jan 24.

Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands.

Although partial thickness burns are the most frequently reported burn injuries, there is no consensus on the optimal treatment. The objective of this study was to compare the clinical effectiveness and scar quality of Flaminal® Forte to silver sulfadiazine (Flamazine®) in the treatment of partial thickness burns. In this two-arm open label multicenter randomized controlled trial, adult patients with acute partial thickness burns and an affected total body surface area of less than 30% were randomized between Flaminal® Forte and Flamazine® and followed for 12 months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/wrr.12699DOI Listing
January 2019
1 Read

Assessment of biofilm formation among clinical isolates of Acinetobacter baumannii in burn wounds in the west of Iran.

Cell Mol Biol (Noisy-le-grand) 2018 Dec 31;64(15):30-34. Epub 2018 Dec 31.

Fertility and Sterility Research Center, and Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Burn wound infection by A. baumannii is one of the predominant cause of mortality worldwide. The present investigation aimed at determination of antimicrobial resistance profile and expression of the biofilm-related genes in A. Read More

View Article

Download full-text PDF

Source
December 2018

Screening and preliminary validation of T lymphocyte immunoregulation‑associated long non‑coding RNAs in diabetic foot ulcers.

Mol Med Rep 2019 Mar 17;19(3):2368-2376. Epub 2019 Jan 17.

Department of Surgery, Yijishan Hospital, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui 241001, P.R. China.

The present study aimed to investigate the existence of immunoregulation‑associated long non‑coding (lnc)RNAs mediated by T lymphocytes in the wound surfaces of diabetic foot ulcers (DFUs). The wound skin tissues of patients receiving debridement for trauma or DFUs associated with infection were obtained. Dermatological histological changes were observed by pathological staining, and T lymphocyte subsets and inflammation‑associated cytokines were identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/mmr.2019.9877DOI Listing
March 2019
3 Reads

Complication of solar branding: Report of a case and the review of the literature.

Clin Case Rep 2019 Jan 20;7(1):104-106. Epub 2018 Nov 20.

Johns Hopkins University School of Medicine Johns Hopkins Burn Center Baltimore Maryland.

Branding is a type of scarification, a body modification that permanently transforms the skin by causing a visible scar. For centuries, it has been used on the skin of animals and slaves as well as criminals to convey ownership and also as a proof of guilt. More recently (in the 20th and 21st centuries), branding has become a symbol of personal identity, rites of passage, spiritual beliefs, and body decoration in some particular microcultures. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/ccr3.1847
Publisher Site
http://dx.doi.org/10.1002/ccr3.1847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333081PMC
January 2019
3 Reads

Nano-engineered lipid-polymer hybrid nanoparticles of fusidic acid: an investigative study on dermatokinetics profile and MRSA-infected burn wound model.

Drug Deliv Transl Res 2019 Jan 16. Epub 2019 Jan 16.

University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh, 160 014, India.

Staphylococcus aureus (SA) and methicillin-resistant Staphylococcus aureus (MRSA) have been a major cause of morbidity in thermally injured patients. The skin barrier gets disrupted and loss of immunity further makes burn sites an easy target for bacterial colonization. In the current study, combined potential of lipid-polymer hybrid nanoparticles (LPHNs) with fusidic acid was explored as a promising strategy toward combating resistant bacteria in burn wound infection sites. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13346-019-00616-3DOI Listing
January 2019
2 Reads

Silver sulfadiazine nanosuspension-loaded thermosensitive hydrogel as a topical antibacterial agent.

Int J Nanomedicine 2019 28;14:289-300. Epub 2018 Dec 28.

Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, People's Republic of China,

Background: Silver sulfadiazine (AgSD) is widely employed as an antibacterial agent for surface burn management. However, the antibacterial activity of AgSD was restrained because of the lower drug solubility and possible cytotoxicity.

Objective: This study aimed to formulate stable silver sulfadiazine/nanosuspensions (AgSD/NSs) with improved AgSD solubility and prepare a suitable carrier for AgSD/NS delivery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/IJN.S187918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314312PMC
February 2019
3 Reads

Fibrin tissue sealant and minor skin grafts in burn surgery: A systematic review and meta-analysis.

J Plast Reconstr Aesthet Surg 2019 Jan 8. Epub 2019 Jan 8.

Division of Plastic & Reconstructive Surgery, University Hospitals Cleveland Medical Center, 11100 Euclid Avenue, LKSD Suite 5206 Mailstop 5044, Cleveland, OH 44106-5068, USA.

Background: The indications for use of fibrin glue in skin grafting burn patients remains understudied. The purpose of this study is to review the efficacy of fibrin tissue sealant in skin graft adherence, establish guidelines for use of fibrin tissue sealant, and review the cost effectiveness of fibrin glue.

Methods: Publications with the following criteria were included: comparative human studies, autologous skin grafts, and autologous or commercial fibrin sealant. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bjps.2018.12.036DOI Listing
January 2019

Suppression of neovascularization in corneal stroma in a TRPA1-null mouse.

Exp Eye Res 2019 Jan 8;181:90-97. Epub 2019 Jan 8.

Department of Ophthalmology, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-0012, Japan.

Corneal neovascularization and inflammatory fibrosis induced by severe injury or infection leads to tissue opacification and even blindness. Transient receptor potential (TRP) channel subtypes contribute to mediating these maladaptive responses through their interactions with other receptors. TRPV1 is one of the contributing channel isoforms inducing neovascularization in an alkali burn mouse wound healing model. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00144835183008
Publisher Site
http://dx.doi.org/10.1016/j.exer.2019.01.002DOI Listing
January 2019
5 Reads

Pathogen-Specific Polymeric Antimicrobials with Significant Membrane Disruption and Enhanced Photodynamic Damage to Inhibit Highly Opportunistic Bacteria.

ACS Nano 2019 Jan 11. Epub 2019 Jan 11.

Highly pathogenic Gram-negative bacteria and the drug resistance are severe public health threat with high mortality. Gram-negative bacteria are hard to kill due to the complex cell envelopes with low permeability and extra defensive mechanisms. It is challenging to treat them by current strategies, mainly including antibiotics, peptides, polymers, and some hybrid materials, still facing the issue of drug resistance, limited antibacterial selectivity, and severe side effects. Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acsnano.8b07251
Publisher Site
http://dx.doi.org/10.1021/acsnano.8b07251DOI Listing
January 2019
6 Reads

Negative Pressure Wound Therapy with Instillation and Dwell for the Management of a Complex Burn: A Case Report and Review of the Literature.

Cureus 2018 Oct 29;10(10):e3514. Epub 2018 Oct 29.

Plastic and Reconstructive Surgery, The University of Texas Medical Branch, Galveston, USA.

Research over the last 50 years has led to significant improvements in outcomes for burn victims. Advances in infection control, attenuation of the hypermetabolic response, and new improved surgical approaches have led to decreased morbidity and mortality. Early wound excision eliminates the devitalized tissue, which is the main reservoir for pathogen propagation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7759/cureus.3514DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314793PMC
October 2018
6 Reads

Utilizing Negative Pressure Wound Therapy with Instillation and Dwell Time for Extensive Necrotizing Fasciitis of the Lower Extremity: A Case Report.

Cureus 2018 Oct 23;10(10):e3483. Epub 2018 Oct 23.

Orthopedic Surgery, Queen's Medical Center, Honolulu, USA.

Necrotizing fasciitis is a rapidly spreading infection of the soft tissue, which carries significant morbidity and mortality. This condition is treated with broad-spectrum antibiotics, irrigation and surgical debridement of the affected area, and hemodynamic support. Negative pressure wound therapy (NPWT) has been utilized after surgical debridement to promote wound healing, especially when significant debridement has occurred. Read More

View Article

Download full-text PDF

Source
https://www.cureus.com/articles/15314-utilizing-negative-pre
Publisher Site
http://dx.doi.org/10.7759/cureus.3483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314797PMC
October 2018
7 Reads

Advanced drug delivery systems and artificial skin grafts for skin wound healing.

Adv Drug Deliv Rev 2018 Dec 31. Epub 2018 Dec 31.

Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA; Department of Systems Biology, Columbia University Medical Center, New York, NY 10032, USA. Electronic address:

Cutaneous injuries, especially chronic wounds, burns, and skin wound infection, require painstakingly long-term treatment with an immense financial burden to healthcare systems worldwide. However, clinical management of chronic wounds remains unsatisfactory in many cases. Various strategies including growth factor and gene delivery as well as cell therapy have been used to enhance the healing of non-healing wounds. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S0169409X183031
Publisher Site
http://dx.doi.org/10.1016/j.addr.2018.12.014DOI Listing
December 2018
5 Reads
15.038 Impact Factor

Common hydrotherapy practices and the prevalence of burn wound bacterial colonisation at the University Teaching Hospital in Lusaka, Zambia.

Burns 2018 Dec 27. Epub 2018 Dec 27.

Department of Pathology, University Teaching Hospital, Private Bag 1X RW, Lusaka, Zambia.

Background: In many parts of the world, hydrotherapy plays an important role in the management of patients with wounds including burns. Different centers practice hydrotherapy differently. At the University Teaching Hospital in Lusaka, Zambia, burn patients use a common bathtub for cleaning their wounds which theoretically increases the risk of cross-infection, an important source of morbidity and mortality. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03054179183030
Publisher Site
http://dx.doi.org/10.1016/j.burns.2018.11.019DOI Listing
December 2018
11 Reads

[The features and treatment of Xixia "May 17th" explosion accident].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2018 Dec;30(12):1196-1199

Department of Burns and Plastic Surgery, the Affiliated Nanshi Hospital of Henan University, Nanyang 473065, Henan, China. Corresponding author: Wang Shuo, Email:

Objective: To retrospectively analyze the injury characteristics of victims and treatment strategies in the explosion accident on the 17th May 2018 in Xixia county (Xixia "May 17th" explosion accident).

Methods: Completion the Level Three treatment on time, which was depended on the leading role played by the regional trauma centers was the main rescuing mode of the work in Xixia county, where the primary and secondary treatments were the key parts. The three-level treatment model includes: the local hospital acts as a level-one emergency medical institution, county hospitals function as secondary emergency medical institutions, and other higher medical institutions are the tertiary first aid medical institutions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2018.012.018DOI Listing
December 2018
8 Reads

Redox Profiling Reveals Clear Differences between Molecular Patterns of Wound Fluids from Acute and Chronic Wounds.

Oxid Med Cell Longev 2018 18;2018:5286785. Epub 2018 Nov 18.

Department of Dermatology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Wound healing is a complex multiphase process which can be hampered by many factors including impaired local circulation, hypoxia, infection, malnutrition, immunosuppression, and metabolic dysregulation in diabetes. Redox dysregulation is a common feature of many skin diseases demonstrated by virtually all cell types in the skin with overproduction of reactive oxygen and nitrogen species. The objective of this study was to characterize the redox environment in wound fluids and sera from patients suffering from chronic leg ulcers ( = 19) and acute wounds (bulla fluids from second degree burns; = 11) with serum data also compared to those from healthy volunteers ( = 7). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1155/2018/5286785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276414PMC
January 2019
1 Read

Reconstruction of post-traumatic upper extremity soft tissue defects with pedicled flaps: An algorithmic approach to clinical decision making.

Chin J Traumatol 2018 Dec 5;21(6):338-351. Epub 2018 Nov 5.

Department of Plastic Reconstructive & Burns Surgery, All India Institute of Medical Sciences, New Delhi, India. Electronic address:

Purpose: Pedicled flaps are still the workhorse flaps for reconstruction of upper limb soft tissue defects in many centers across the world. They are lifeboat options for coverage in vessel deplete wounds. In spite of their popularity existing algorithms are limited to a particular region of upper limb; a general algorithm involving entire upper limb which helps in clinical decision making is lacking. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10081275183001
Publisher Site
http://dx.doi.org/10.1016/j.cjtee.2018.04.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354178PMC
December 2018
11 Reads

Human acellular amniotic membrane implantation for lower third nasal reconstruction: a promising therapy to promote wound healing.

Burns Trauma 2018 18;6:34. Epub 2018 Dec 18.

7Shenzhen Engineering Laboratory of Orthopaedic Regenerative Technologies, Orthopaedic Research Center, Peking University Shenzhen Hospital, Shenzhen, China.

Background: The lower third of the nose is one of the most important cosmetic units of the face, and its reconstructive techniques remain a big challenge. As an alternative approach to repair or regenerate the nasal tissue, the biomaterial-based strategy has been extensively investigated. The aim of this study is to determine the safety and efficacy of human acellular amniotic membrane (HAAM) to repair the full-thickness defects in the lower third of the nose in humans. Read More

View Article

Download full-text PDF

Source
https://burnstrauma.biomedcentral.com/articles/10.1186/s4103
Publisher Site
http://dx.doi.org/10.1186/s41038-018-0136-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297938PMC
December 2018
10 Reads

Betulin wound gel accelerated healing of superficial partial thickness burns: Results of a randomized, intra-individually controlled, phase III trial with 12-months follow-up.

Burns 2018 Dec 14. Epub 2018 Dec 14.

Burn Center with Plastic Surgery, Unfallkrankenhaus Berlin, Germany. Electronic address:

Objective: Acceleration of wound healing promises advantages for patients and caregivers in reducing the burden of disease, avoiding complications such as wound infections, and improving the long-term outcome. However, medicines that can accelerate wound healing are lacking. The objective of this open, blindly evaluated, randomized, multicenter phase III study was to compare intra-individually the efficacy and tolerability of Oleogel-S10 with fatty gauze dressing versus Octenilin wound gel with fatty gauze dressing in accelerating the healing of superficial partial thickness burn wounds. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03054179183054
Publisher Site
http://dx.doi.org/10.1016/j.burns.2018.10.019DOI Listing
December 2018
6 Reads

Whole genome sequence analysis of NDM-1, CMY-4, and SHV-12 coproducing serovar Typhimurium isolated from a case of fatal burn wound infection.

Infect Drug Resist 2018 28;11:2491-2495. Epub 2018 Nov 28.

Department of Medical Microbiology and Immunology, RAK College of Medical Sciences, RAK Medical and Health Sciences University (RAKMHSU), Ras Al Khaimah, UAE,

species are frequently associated with gastrointestinal infections such as diarrhea. However, extraintestinal infections, including burn infections, have been described. Here, we report the first case of a carbapenem-resistant and metallo-β-lactamase (New Delhi metallo-β-lactamase), extended-spectrum β-lactamase (SHV-12), and AmpC β-lactamase (CMY-4) coproducing Typhimurium isolated from a fatal case of burn wound infection. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/whole-genome-sequence-analysis-of-
Publisher Site
http://dx.doi.org/10.2147/IDR.S167027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278884PMC
November 2018
8 Reads

Preparation of hydroxylated lecithin complexed iodine/carboxymethyl chitosan/sodium alginate composite membrane by microwave drying and its applications in infected burn wound treatment.

Carbohydr Polym 2019 Feb 29;206:435-445. Epub 2018 Oct 29.

Agriculture Products Processing Research Institute, Chinese Academy of Tropical Agricultural Sciences, Zhanjiang, 524001, PR China.

Improving the antibacterial properties of membrane wound dressings of natural polymers is crucial. Iodine is an important safe inorganic antibacterial agent, but was confined in the composition with polymer membranes due to the challenges of homogeneity and stability during drying. In the present work, iodine was complexed with hydroxylated lecithin (HL) to improve its stability and complexing efficiency for the composition with carboxymethly chitosan/sodium alginate. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S01448617183126
Publisher Site
http://dx.doi.org/10.1016/j.carbpol.2018.10.068DOI Listing
February 2019
4 Reads

Emerging Innovative Wound Dressings.

Ann Biomed Eng 2018 Dec 12. Epub 2018 Dec 12.

Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.

The skin provides a protective barrier to the body against the environment. Ineffective healing of damaged skin can cause a chronic wound which would increase the risk of infection and associated complications. The use of wound dressings to protect the wound and provide an optimal environment for wound repair is a common practice in the burn clinic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10439-018-02186-wDOI Listing
December 2018
1 Read

Disarming the virulence arsenal of by blocking two-component system signaling.

Chem Sci 2018 Oct 10;9(37):7332-7337. Epub 2018 Jul 10.

Department of Chemistry , University of Minnesota , 225 Pleasant St. SE , Minneapolis , MN 55454 , USA . Email:

infections have reached a "critical" threat status making novel therapeutic approaches required. Inhibiting key signaling enzymes known as the histidine kinases (HKs), which are heavily involved with its pathogenicity, has been postulated to be an effective new strategy for treatment. Herein, we demonstrate the potential of this approach with benzothiazole-based HK inhibitors that perturb multiple virulence pathways in the burn wound isolate, PA14. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8sc02496kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6237130PMC
October 2018

Complications after discharge and delays in adjuvant chemotherapy following colonic resection: a cohort study of linked primary and secondary care data.

Colorectal Dis 2018 Dec 10. Epub 2018 Dec 10.

Department of Surgery and Cancer, Imperial College London, London, UK.

Aim: By understanding the reasons for delays in adjuvant chemotherapy (AC) after colonic resection, there is the potential to improve patient outcome. The aim of this study is to determine the extent and impact of complications after hospital discharge on delays to AC.

Method: The study cohort included patients from Hospital Episode Statistics (HES) who had a colorectal cancer resection; linkage to primary care data was provided by the Clinical Practice Research Datalink (CPRD). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/codi.14525DOI Listing
December 2018

Successful Use of Negative-pressure Wound Therapy and Dermal Substitute in the Treatment of Gluteal Ecthyma Gangrenosum in a 2-year-old Girl.

Plast Reconstr Surg Glob Open 2018 Oct 3;6(10):e1953. Epub 2018 Oct 3.

Department of Pediatric Surgery, Meyer Children Hospital, Florence, Italy.

Ecthyma Gangrenosum is a manifestation of infection, usually occurring in immunocompromised patients, which can be associated with bacteremia with potentially lethal outcome. The clinical appearance is of an inflammatory cutaneous lesion with a central necrotic spot; the lesion then rapidly progresses to a gangrenous ulcer with a gray-black eschar extending in the deep soft tissues. Treatment of Ecthyma Gangrenosum includes both aggressive systemic antibiotic therapy and surgical procedures. Read More

View Article

Download full-text PDF

Source
http://Insights.ovid.com/crossref?an=01720096-201810000-0003
Publisher Site
http://dx.doi.org/10.1097/GOX.0000000000001953DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250464PMC
October 2018
5 Reads

Comparative study of conventional and topical heparin treatment in second degree burn patients for burn analgesia and wound healing.

Burns 2018 Dec 7. Epub 2018 Dec 7.

Department of Plastic, Reconstructive Surgery and Burn Unit, King Edward Medical University, Mayo Hospital, Lahore, Pakistan. Electronic address:

Objective: To compare clinical outcome of topical conventional with topical heparin treatment in 2nd degree or partial thickness (PTB) burn patients.

Methods: Patients, between the ages of 14 and 60 years with 2nd degree burns involving <20%. Total body surface area (TBSA) on front of chest, abdomen and upper limbs excluding hands and lower limbs were enrolled from September 2015 to August 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.burns.2018.05.010DOI Listing
December 2018
3 Reads
1.836 Impact Factor

Synthesis and characterization of pyridoxine, nicotine and nicotinamide salts of dithiophosphoric acids as antibacterial agents against resistant wound infection.

Bioorg Med Chem 2019 Jan 13;27(1):100-109. Epub 2018 Nov 13.

Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University, 420008 Kazan, 18 Kremlyovskaya St., Russia. Electronic address:

The pyridine-derived biomolecules are of considerable interest in developing medicinal compounds with various specific activities. Novel ammonium salts of pyridoxine, (S)-(-)-nicotine and nicotinamide with O,O-diorganyl dithiophosphoric acids (DTPA) were synthesized and characterized. The complexation of chiral monoterpenyl DTPA, including (S)-(-)-menthyl, (R)-(+)-menthyl, (1R)-endo-(+)-fenchyl, (1S,2S,3S,5R)-(+)-isopinocampheolyl derivatives, with pyridoxine and nicotine provided effective antibacterial compounds 3a,b,e,f, and 5a,b,d,f with MIC values against Gram-positive bacteria as low as 10 µM (6 µg/mL). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2018.11.017DOI Listing
January 2019
1 Read

Novel pharmacotherapy for burn wounds: what are the advancements.

Expert Opin Pharmacother 2019 Feb 5;20(3):305-321. Epub 2018 Dec 5.

a Wellman Center for Photomedicine , Massachusetts General Hospital , Boston , MA , USA.

Introduction: The prognosis for severe burns has improved significantly over the past 50 years. Meanwhile, burns have become an affliction mainly affecting the less well-developed regions of the world. Early excision and skin grafting has led to major improvements in therapeutic outcomes. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/14656566.2018.1
Publisher Site
http://dx.doi.org/10.1080/14656566.2018.1551880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364296PMC
February 2019
5 Reads

Uptake of PHMB in a bacterial nanocellulose-based wound dressing: A feasible clinical procedure.

Burns 2018 Nov 30. Epub 2018 Nov 30.

Division of Plastic, Aesthetic and Reconstructive Surgery, Department of Surgery, Medical University of Graz, Austria; COREMED - Cooperative Centre for Regenerative Medicine, Joanneum Research Forschungsgesellschaft mbH, Graz, 9 Austria.

Background: With the increase of antimicrobial resistance in recent decades, other methods of preventing and fighting infections must be considered. Burn patients, whose wound areas are often extensive, are especially prone to wound infections. The loading of bacterial nanocellulose (BNC) with antiseptics has already been successfully performed but unfortunately, the described procedure is time-consuming and thus not applicable in a clinical emergency setting. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S03054179183063
Publisher Site
http://dx.doi.org/10.1016/j.burns.2018.10.023DOI Listing
November 2018
12 Reads

Fibrin as a Tissue Adhesive and Scaffold with an Angiogenic Agent (FGF-1) to Enhance Burn Graft Healing In Vivo and Clinically.

J Funct Biomater 2018 Nov 26;9(4). Epub 2018 Nov 26.

Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

There is a need for a strategy to reduce scarring in meshed skin graft healing leading to a better cosmetic result without a significant increase in cost. The strategy in this paper is to increase the closure rate of a meshed skin graft to reduce scarring, which should also decrease the infection rate. Specifically, we used fibrin glue to attach all parts of the graft to the wound bed and added in an angiogenic growth factor and made the fibrin porous to further help the growth of blood vessels from the wound bed into the graft. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jfb9040068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306864PMC
November 2018

[Analysis of distribution and drug resistance of pathogens from the wounds of 1 310 thermal burn patients].

Zhonghua Shao Shang Za Zhi 2018 Nov;34(11):802-808

State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400038, China.

To analyze the distribution and drug resistance of pathogens from the wounds of thermal burn patients, so as to provide reliable basis for the rational use of antibiotics and the effective control over nosocomial infection. Wound samples of 1 310 thermal burn patients admitted into our burn wards from January 2012 to December 2017 were collected and retrospectively analyzed. API bacteria identification panels and automatical bacteria identification equipment were used to identify pathogens. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.1009-2587.2018.11.016DOI Listing
November 2018
1 Read

[National experts consensus on application of silver-containing dressings in wound therapy (2018 version)].

Authors:
Jiaping Zhang

Zhonghua Shao Shang Za Zhi 2018 Nov;34(11):761-765

New silver-containing dressings developed in recent years have brought new and powerful means for the prevention and treatment of wound infection, which promote development and progress of wound therapy. There are many kinds of silver-containing dressings, however, misunderstanding and even misapplication exist in how to choose and use these dressings. Based on literature evidence, we propose this national expert consensus on clinical application of silver-containing dressings, particularly in terms of kinds and mechanisms, indications, contraindications, rational selections in different wounds, and cautions in the clinical application of silver-containing dressings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.1009-2587.2018.11.008DOI Listing
November 2018
8 Reads

Additional Vitamin and Mineral Support for Patients with Severe Burns: A Nationwide Experience from a Catastrophic Color-Dust Explosion Event in Taiwan.

Nutrients 2018 Nov 16;10(11). Epub 2018 Nov 16.

Department of Obstetrics and Gynecology, Taipei Tzu-Chi Hospital, The Buddhist Tzu-Chi Medical Foundation, Taipei 970, Taiwan.

Major burn injuries, which encompass ≥20% of the total body surface area (TBSA), are the most severe form of trauma because of the stress response they provoke, which includes hypermetabolism, muscle wasting, and stress-induced diabetes. In 2015, a color-dust explosion disaster occurred in the Formosa Fun Coast of Taiwan and injured 499 people, who were transferred via a nationwide emergency delivery system. Some recommendations are currently available regarding vitamin and mineral support for wound healing and recovery in severe burns, but there is a lack of evidence to confirm the benefits. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/nu10111782DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266218PMC
November 2018
8 Reads

[National experts consensus on application of silver-containing dressings in wound therapy (2018 version)].

Authors:
J P Zhang

Zhonghua Shao Shang Za Zhi 2018 Nov;34(11):E002

400038 Chongqing, State Key Laboratory of Trauma, Burns and Combined Injury, Department of Plastic Surgery, the First Affiliated Hospital of Army Medical University (the Third Military Medical University).

New silver-containing dressings developed in recent years have brought new and powerful means for the prevention and treatment of wound infection, which promote development and progress of wound therapy. There are many kinds of silver-containing dressings, however, misunderstanding and even misapplication exist in how to choose and use these dressings. Based on literature evidence, we propose this national expert consensus on clinical application of silver-containing dressings, particularly in terms of kinds and mechanisms, indications, contraindications, rational selections in different wounds, and cautions in the clinical application of silver-containing dressings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.1009-2587.2018.11.E002DOI Listing
November 2018
6 Reads