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    Highly effective Cu/Zn-carbon micro/nanofiber-polymer nanocomposite-based wound dressing biomaterial against the P. aeruginosa multi- and extensively drug-resistant strains.
    Mater Sci Eng C Mater Biol Appl 2017 Aug 31;77:630-641. Epub 2017 Mar 31.
    Department of Bioscience and Biotechnology, Banasthali University, Banasthali, 304022, India.
    Pseudomonas aeruginosa (P. aeruginosa) is the most prevalent bacteria in the infections caused by burn, surgery, and traumatic injuries. Emergence of the P. Read More

    The use of Biobrane(®) for wound coverage in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
    Burns 2017 May 16. Epub 2017 May 16.
    Ross Tilley Burn Centre, Toronto, Canada. Electronic address:
    Introduction: Published experience describing the use of Biobrane(®) for wound management in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS-TEN) is limited to case reports and case series involving ten or fewer patients. We have used Biobrane(®) in the care of SJS-TEN since 2000, and the purpose of this study was to review our experience with the application of Biobrane(®) for wound coverage in SJS-TEN.

    Methods: A retrospective review of all cases of SJS-TEN admitted to an adult regional ABA-verified burn center between January 1, 2000 and June 1, 2015 was conducted. Read More

    The Role of Phytochemicals in the Inflammatory Phase of Wound Healing.
    Int J Mol Sci 2017 May 16;18(5). Epub 2017 May 16.
    Department of Surgery, University of Toronto, Toronto, ON M5S 1A8, Canada.
    Historically, plant-based products have been the basis of medicine since before the advent of modern Western medicine. Wound dressings made of honey, curcumin and other phytochemical-rich compounds have been traditionally used. Recently, the mechanisms behind many of these traditional therapies have come to light. Read More

    A Retrospective Chart Review of Chronic Wound Patients Treated with Topical Oxygen Therapy.
    Adv Wound Care (New Rochelle) 2017 May;6(5):143-152
    Angie Purvis, LLC, Evergreen, Colorado.
    Objective: Topical oxygen devices are Food and Drug Administration (FDA) cleared for the following indications for use of various etiologies: skin ulcerations due to diabetes, venous stasis, postsurgical infections and gangrenous lesions, decubitus ulcers; amputations/infected stumps; skin grafts; burns; and frostbite. The goal of this study was to understand the impact of topical oxygen therapy (TOT) on patient outcomes, including amputation and healing rates. Approach: This retrospective chart review included records collected between January 1, 2007, and July 18, 2016, from male and female patients ranging in age from 4 years to 105 years. Read More

    Antibacterial efficacy of poly(vinyl alcohol) composite nanofibers embedded with silver-anchored silica nanoparticles.
    J Biomed Mater Res B Appl Biomater 2017 May 15. Epub 2017 May 15.
    Nano Fusion Technology Research Lab, Division of Frontier Fibers, Institute for Fiber Engineering (IFES), Interdisciplinary Cluster for Cutting Edge Research (ICCER), Shinshu University 3-15-1, Tokida, Ueda, Nagono, 386-8567, Japan.
    Silver has been widely used as an effective antibacterial agent especially for treating burns and wounds. However, release of silver from materials often arouse side effects due to toxicity of silver towards mammalian cells. Argyria and argyrosis are well known problems of acute toxicity of silver towards human body. Read More

    Wound Healing Property Review of Siam Weed, Chromolaena odorata.
    Pharmacogn Rev 2017 Jan-Jun;11(21):35-38
    Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
    Chromolaena odorata (Family: Asteraceae) synonyms as Eupatorium odoratum is a traditional medicinal plant that is widely used for its wound healing property. In particular, the several parts of this herb have been used to treat wounds, burns, and skin infections. Furthermore, it has also been shown to possess anticancer, antidiabetic, anti-hepatotoxic, anti-inflammatory, antimicrobial, and antioxidant properties. Read More

    Liposome loaded phage cocktail: Enhanced therapeutic potential in resolving Klebsiella pneumoniae mediated burn wound infections.
    Burns 2017 May 11. Epub 2017 May 11.
    Department of Microbiology, Panjab University, Chandigarh 160014, India. Electronic address:
    Background: Klebsiella pneumoniae is one of the predominant pathogens in burn wound infections, and prevalence of multidrug resistant strains has further complicated the situation. An increased interest in phage therapy as a means of combating infection has been accruing in recent years. In order to overcome the drawbacks associated with phage therapy, the present study was conducted to evaluate the potential of liposomes as a delivery vehicle for phage in the treatment of burn wound infection. Read More

    Acinetobacter baumannii quorum-sensing signalling molecule induces the expression of drug-resistance genes.
    Mol Med Rep 2017 Jun 28;15(6):4061-4068. Epub 2017 Apr 28.
    Department of Burns and Plastic Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China.
    Quorum-sensing signalling molecules such as N‑acyl homoserine lactones (AHLs) enable certain Gram‑negative bacteria to respond to environmental changes through behaviours, such as biofilm formation and flagellar movement. The present study aimed to identify Acinetobacter baumannii AHLs and assess their influence on antibiotic resistance. A clinical isolate of A. Read More

    A 27-Year Follow-Up for a Patient With 100% Total Body Surface Area Burn.
    J Burn Care Res 2017 May 8. Epub 2017 May 8.
    From the *Department of Burns and Wound Care Center, Second Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, China.
    Patients suffering from severe 100% TBSA burns are particularly vulnerable to infection and multiple organ dysfunction syndrome, being on high risks of poor outcomes. Treatment of these patients remains to be a great challenge for burn physicians, and survivors of 100% TBSA burns generally have poor quality of life after burn. Since, to our knowledge, this is the first case report on the long-term follow-up of a 100% TBSA burn survivor, the authors are presenting the initial injury, treatment, and follow-up of this female patient during 27 years. Read More

    Histopathological comparisons of Staphylococcus aureus and Pseudomonas aeruginosa experimental infected porcine burn wounds.
    Wound Repair Regen 2017 May 2. Epub 2017 May 2.
    Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio.
    Chronic skin wounds are a significant human health concern and are often complicated by infection with Pseudomonas aeruginosa and Staphylococcus aureus, particularly methicillin resistant S. aureus (MRSA). Translating the knowledge gained from extensive study of virulence mechanisms and pathogenesis of these bacterial species to new treatment modalities has been lacking in part due to a paucity of animal models able to recapitulate human disease. Read More

    Characterization of Mycobacterium marinum Infections in Zebrafish Wounds and Sinus Tracts.
    Wound Repair Regen 2017 May 2. Epub 2017 May 2.
    Department of Burns and Plastic Surgery, The 309th Hospital of PLA, No. 17, Heishanhu Street, Beijing, 100091, China.
    The impaired healing of Mycobacterium tuberculosis-infected wounds is a clinical challenge, and the mechanisms involved are still not clear. The zebrafish model of Mycobacterium marinum infection has provided surprising insights into the pathogenesis of tuberculosis in humans. Similarly, the major principles and phases of cutaneous wound healing are conserved among adult mammals and adult zebrafish. Read More

    [Advance on human umbilical cord mesenchymal stem cells for treatment of ALI in severe burns].
    Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2017 Jan;29(1):90-96
    Graduate School, Jinzhou Medical University, Jinzhou 121000, Liaoning, China (Wang Y); Department of Pediatrics, the First Affiliated Hospital to PLA General Hospital, Beijing 100048, China (Hu XH). Corresponding author: Hu Xiaohong, Email:
    Objective: Severe burn is often accompanied by multiple organ damage. Acute lung injury (ALI) is one of the most common complications, and often occurs in the early stage of severe burns. If it is not treated in time, it will progress to acute respiratory distress syndrome (ARDS), which will be a serious threat to the lives of patients. Read More

    Surgical treatment and management of the severely burn patient: Review and update.
    Med Intensiva 2017 Apr 26. Epub 2017 Apr 26.
    Plastic Surgeon, Plastic and Reconstructive Department, Burns Unit, Virgen del Rocio University Hospital, Sevilla, Spain. Electronic address:
    Since one of the main challenges in treating acute burn injuries is preventing infection, early excising of the eschar and covering of the wound becomes critical. Non-viable tissue is removed by initial aggressive surgical debridement. Many surgical options for covering the wound bed have been described, although split-thickness skin grafts remain the standard for the rapid and permanent closure of full-thickness burns. Read More

    Are anaerobes a major, underappreciated cause of necrotizing infections?
    Anaerobe 2017 Apr 24. Epub 2017 Apr 24.
    Departments of Surgery, Texas Tech University Health Sciences Center, Lubbock, TX, United States; Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, TX, United States; TTUHSC Surgery Burn Center of Research Excellence, Texas Tech University Health Sciences Center, Lubbock, TX, United States. Electronic address:
    Necrotizing soft tissue infections (NSTIs) are the most severe and rapidly progressing class of skin and soft tissue infections (SSTIs). They are a surgical emergency and are associated with high mortality and morbidity. While NSTIs remain relatively rare, their incidence is steadily rising. Read More

    The Use of the MolecuLight i: X in Managing Burns: A Pilot Study.
    J Burn Care Res 2017 Apr 21. Epub 2017 Apr 21.
    From the *University College London, United Kingdom; †Queen Elizabeth Hospital Birmingham, United Kingdom; and ‡Birmingham Burn Centre, The Queen Elizabeth Hospital, United Kingdom.
    The MolecuLight i:X Imaging Device is a portable, noninvasive, real-time camera used to visualize the bacterial load in a wound. It uses violet light illumination and a dual bandpass optical filter to capture the fluorescence of endogenous structures in the tissue matrix and harmful bacteria. The MolecuLight i:X captures images of wounds and highlights potentially detrimental levels of bacteria. Read More

    Is antibiotic prophylaxis in breast augmentation necessary? A prospective study.
    Plast Surg (Oakv) 2016 19;24(3):195-198. Epub 2016 Aug 19.
    Kosmesis Aesthetic Plastic Surgery Centre, Athens, Greece.
    Background: The role of prophylactic antibiotics in breast augmentation remains controversial. However, the majority of surgeons are administering antibiotics.

    Objective: To investigate the effect of antibiotic(s) use in the incidence of infection and capsular contracture following breast augmentation. Read More

    Evaluation of a new tension relief system for securing wound closure: A single-centre, Chinese cohort study.
    Plast Surg (Oakv) 2016 19;24(3):177-182. Epub 2016 Aug 19.
    Department of Plastic Surgery, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hang Zhou, People's Republic of China.
    Background: Wounds that have been closed under excessive tension, and skin defects that cannot be closed primarily, pose a daily challenge for the reconstructive surgeon.

    Objective: To evaluate a new tension relief system (TRS) device for skin stretching and secure wound closure.

    Methods: From September 2013 to March 2014, a consecutive series of 41 Chinese patients with 43 wounds were enrolled for application of 50 cycles of TRS therapy. Read More

    Utilization of PFGE as a Powerful Discriminative Tool for the Investigation of Genetic Diversity among MRSA Strains.
    Iran J Public Health 2017 Mar;46(3):351-356
    Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant challenge to the burn patient. The implementation of proper monitoring programs and prompt identification of epidemic MRSA strains are critical to consequently control and eradicate potential outbreaks. This study aimed to define the genetic relatedness of MRSA strains isolated from burn patients by analyzing the large fragments of DNA. Read More

    Nutrition and metabolism in burn patients.
    Burns Trauma 2017 17;5:11. Epub 2017 Apr 17.
    University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390 USA.
    Severe burn causes significant metabolic derangements that make nutritional support uniquely important and challenging for burned patients. Burn injury causes a persistent and prolonged hypermetabolic state and increased catabolism that results in increased muscle wasting and cachexia. Metabolic rates of burn patients can surpass twice normal, and failure to fulfill these energy requirements causes impaired wound healing, organ dysfunction, and susceptibility to infection. Read More

    [Advances in the research of treatment of burns in the elderly].
    Zhonghua Shao Shang Za Zhi 2017 Apr;33(4):251-254
    Department of Burns, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
    With our country going into the aging society, burns in the elderly often occur. Studies have shown that the number of elderly burn patients has reached 13% to 20% of the total number of burn patients. As the sensory and cognitive functions are low, skin is thinning, the functions of heart, lung, and kidney are reduced, the immunity is impaired, and other physiological characteristics exist in the elderly, the wounds of elderly burn patients often heal slowly, and the mortality is high. Read More

    Salve and Burdock: A Safe, Effective Amish Remedy for Treatment of Traumatic Wounds?
    Adv Skin Wound Care 2017 May;30(5):213-217
    Mitchell D. Flurry, MD, is Assistant Professor, Plastic Surgery & Aesthetics, Wichita, Kansas. Kelsie L. Herring, BA, Medical Student, graduates to MD in May 2017; Logan W. Carr, MD, is Resident Physician; Randy M. Hauck, MD, is Associate Professor of Surgery; and John D. Potochny, MD, is Associate Professor of Surgery, Pennsylvania State College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania.
    Background: Amish patients show a demonstrated preference for traditional, herbal remedies over modern medical interventions such as skin grafting. One such remedy is a mixture of Burn & Wound Ointment (B & W Ointment; Holistic Acres, LLC; Newcomerstown, Ohio) and steeped burdock leaves. Although both have demonstrated some antimicrobial and wound healing properties, burdock and/or the combination of B & W Ointment and burdock has never been studied to determine its purported ability to reduce pain, prevent infection, and accelerate wound healing. Read More

    In-vitro discrimination of wound associated bacteria by volatile compound profiling using Selected Ion Flow Tube - Mass Spectrometry.
    J Appl Microbiol 2017 Apr 19. Epub 2017 Apr 19.
    University of the West of England Centre for Research in Biosciences, Faculty of Health and Applied Sciences, University of the West of England, Bristol, UK, BS16 1QY.
    Aims: To determine if bacterial species responsible for clinically relevant wound infection produce specific volatile profiles that would allow their speciation.

    Methods And Results: Selected-Ion Flow Tube-Mass Spectrometry in full mass scan mode was used to analyse headspace gases produced by wound-associated bacteria grown in vitro, so as to enable identification of bacterial volatile product ion profiles in the resulting mass spectra. Applying multivariate statistical analysis (hierarchical clustering and principal component analysis) to the resultant mass spectra enabled clear speciation. Read More

    Management of the extensive thoracic defects after deep sternal wound infection with the rectus abdominis myocutaneous flap: A retrospective case series.
    Medicine (Baltimore) 2017 Apr;96(16):e6391
    aDepartment of Burns and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University bXi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
    Deep sternal wound infection is a severe complication after open heart surgery. According to the different severity and dimensions of the deep sternal wound infection, the treatment method is different. In this study, we aimed to describe our experience with the rectus abdominis myocutaneous flap for large sternal wound management, especially when 1 or 2 internal mammary arteries were absent. Read More

    Screening nasal swabs for methicillin resistant Staphylococcus aureus: A regional burn center's experience.
    Burns 2017 Jun 12;43(4):771-779. Epub 2017 Apr 12.
    The Burn Center, Department of Surgery, MedStar Washington Hospital Center, Washington, DC, United States; Firefighters' Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, DC, United States. Electronic address:
    Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen that can result in substantial morbidity and mortality. Early detection of MRSA colonization by screening nasal swabs may be important in the management of burn-injured patients. However, studies examining its use in this population are limited. Read More

    Lignin-graft-Polyoxazoline Conjugated Triazole a Novel Anti-Infective Ointment to Control Persistent Inflammation.
    Sci Rep 2017 Apr 12;7:46412. Epub 2017 Apr 12.
    Central Research Facility, Rubber Technology Centre, Indian Institute of Technology Kharagpur, Kharagpur 721302, WB, India.
    Lignin, one of the most abundant renewable feedstock, is used to develop a biocompatible hydrogel as anti-infective ointment. A hydrophilic polyoxazoline chain is grafted through ring opening polymerization, possess homogeneous spherical nanoparticles of 10-15 nm. The copolymer was covalently modified with triazole moiety to fortify the antimicrobial and antibiofilm activities. Read More

    Accelerated re-epithelialization of partial-thickness skin wounds by a topical betulin gel: Results of a randomized phase III clinical trials program.
    Burns 2017 Apr 8. Epub 2017 Apr 8.
    Department of Oral and Maxillofacial Surgery/Plastic Surgery, University Medicine Greifswald, Ferdinand-Sauerbruch-Str. DZ7, 17475 Greifswald, Germany.
    The clinical significance of timely re-epithelialization is obvious in burn care, since delayed wound closure is enhancing the risk of wound site infection and extensive scarring. Topical treatments that accelerate wound healing are urgently needed to reduce these sequelae. Evidence from preliminary studies suggests that betulin can accelerate the healing of different types of wounds, including second degree burns and split-thickness skin graft wounds. Read More

    Stochasticity among Antibiotic-Resistance Profiles of Common Burn-Related Pathogens over a Six-Year Period.
    Surg Infect (Larchmt) 2017 Apr 24;18(3):327-335. Epub 2017 Feb 24.
    1 Pritzker School of Medicine, University of Chicago , Chicago, Illinois.
    Background: One of the most significant contributors to morbidity and death in patients with burns is infection, which accounts for 30%-75% of post-burn fatalities. Because of concerns for the development of antibiotic resistance in burn-related pathogens, the aims of this study were to identify antibiotic resistance trends for the four most common burn-related pathogens over a six-year period.

    Patients And Methods: The study used prospectively collected and de-identified aggregate data for all burn patients admitted to the burn unit between 2009 and 2014. Read More

    Cytotoxicity testing of burn wound dressings: first results.
    Cell Tissue Bank 2017 Jun 7;18(2):143-151. Epub 2017 Apr 7.
    Teaching Department of Burns and Reconstructive Surgery and Central Tissue Bank, Medical Faculty, Comenius University, Bratislava, Slovakia.
    Topical antimicrobial therapy represents an essential part of burn wound care. In order to prevent and treat burn wound infection dressings with antimicrobial properties are applied directly on the wound surface. Not only the infection control but also promotion of healing is very important in burn wound management. Read More

    Norfloxacin and metronidazole topical formulations for effective treatment of bacterial infections and burn wounds.
    Interv Med Appl Sci 2016 Jun;8(2):68-76
    Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo , São Paulo, Brazil.
    Introduction: Our various previous findings have shown the suitability of norfloxacin in the treatment of bacterial infections and burn wounds in alone as well as in combination with Curcuma longa in various topical (ointments, gels, and creams) and transdermal drug delivery systems.

    Aims And Methods: Keeping these facts in consideration, we have made an another attempt to prepare semisolid formulations containing 1% w/w of norfloxacin and metronidazole with different bases like Carbopol, polyethylene glycol, and hydroxypropylmethyl cellulose for effective treatment of bacterial infections and burn wounds. The prepared formulations were evaluated for physicochemical parameters, in vitro drug release, antimicrobial activity, and burn wound healing properties. Read More

    Cutaneous Burn Injury Promotes Shifts in the Bacterial Microbiome in Autologous Donor Skin: Implications for Skin Grafting Outcomes.
    Shock 2017 Mar 31. Epub 2017 Mar 31.
    *Burn & Shock Trauma Research Institute, Loyola University Chicago, Health Sciences Campus, Maywood, IL, USA †Department of Surgery, Loyola University Chicago, Health Sciences Campus, Maywood, IL, USA ‡Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Health Sciences Campus, Maywood, IL, USA §Center for Biomedical Informatics, Loyola University Chicago, Health Sciences Campus, Maywood, IL, USA ¶Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA ||Departments of Dermatology and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
    Introduction: The cutaneous microbiome maintains skin barrier function, regulates inflammation, and stimulates wound healing responses. Burn injury promotes an excessive activation of the cutaneous and systemic immune response directed against commensal and invading pathogens. Skin grafting is the primary method of reconstructing full-thickness burns, and wound infection continues to be a significant complication. Read More

    A 3-Phase Approach for the Management of Upper Extremity Electrical Injuries.
    Hand Clin 2017 May 21;33(2):243-256. Epub 2017 Feb 21.
    Hand Fellowship, Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8238, St Louis, MO 63110, USA. Electronic address:
    Upper extremity electrical injuries present with unique pathophysiologic considerations due to the differing mechanisms of injury produced by the electromagnetic field. The initial phase of treatment consists of recognition of other life-threatening injuries, stabilization of patients, and multisystem resuscitation. The second phase of treatment consists of excising devitalized tissue, appropriate wound care to prevent delayed infection, providing temporary and definitive coverage over vital structures, and preventing contracture and joint stiffness via aggressive therapy. Read More

    Tenth European Consensus Conference on Hyperbaric Medicine: recommendations for accepted and non-accepted clinical indications and practice of hyperbaric oxygen treatment.
    Diving Hyperb Med 2017 Mar;47(1):24-32
    European Committee for Hyperbaric Medicine.
    The tenth European Consensus Conference on Hyperbaric Medicine took place in April 2016, attended by a large delegation of experts from Europe and elsewhere. The focus of the meeting was the revision of the European Committee on Hyperbaric Medicine (ECHM) list of accepted indications for hyperbaric oxygen treatment (HBOT), based on a thorough review of the best available research and evidence-based medicine (EBM). For this scope, the modified GRADE system for evidence analysis, together with the DELPHI system for consensus evaluation, were adopted. Read More

    Nano-silver-decorated microfibrous eggshell membrane: processing, cytotoxicity assessment and optimization, antibacterial activity and wound healing.
    Sci Rep 2017 Mar 27;7(1):436. Epub 2017 Mar 27.
    Institute of Burn Research, State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, the Third Military Medical University, Chongqing, 400038, China.
    An ideal wound dressing can both promote wound healing and prevent bacterial infection. Here, we report a potential dressing prepared by incorporating an optimized concentration of silver nanoparticles (AgNPs) into the microfibers of a natural eggshell membrane (EM) using environmentally friendly and mussel-inspired dopamine. Briefly, acid-treated EM was used as a porous membrane for polydopamine-reduced AgNPs synthesis. Read More

    Occlusive drainage system for split-thickness skin graft: A prospective randomized controlled trial.
    Burns 2017 Mar 27;43(2):379-387. Epub 2016 Oct 27.
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:
    Background: Split-thickness skin grafts are widely used in reconstruction of large area defects. Conventional postoperative recipient site care includes saline-moistened gauze with a protective layer of petroleum gauze and splints for immobilization. This method causes pain while changing the dressing. Read More

    The ability of selected plant essential oils to enhance the action of recommended antibiotics against pathogenic wound bacteria.
    Burns 2017 Mar 27;43(2):310-317. Epub 2016 Oct 27.
    Department of Allergology and Respiratory Rehabilitation, 2nd Chair of Otolaryngology, Medical University of Lodz, Poland.
    The aim of this work was to characterize the ability of essential oils to support antibiotics against pathogenic bacteria in wounds. Gram-positive and Gram-negative bacteria obtained from wound infections were identified according to standard microbiological methods. Essential oils were analysed by GC-FID-MS. Read More

    Burn Wound Healing and Tissue Engineering.
    J Burn Care Res 2017 May/Jun;38(3):e605-e613
    *Department of Emergency Medicine, Stony Brook University, Stony Brook, New York; and †Department of Surgery, University of Cincinnati, Ohio.
    In 2016 the American Burn Association held a State of the Science conference to help identify burn research priorities for the next decade. The current paper summarizes the work of the sub-committee on Burn Wound Healing and Tissue Engineering. We first present the priorities in wound healing research over the next 10 years. Read More

    Surgical Management of Hidradenitis Suppurativa: A 14-Year Retrospective Review of 98 Consecutive Patients.
    J Burn Care Res 2017 Mar 15. Epub 2017 Mar 15.
    From the *Department of Surgery, University of Iowa; †Department of Surgery, University of Arkansas and Arkansas Children's Hospital, Little Rock; and ‡Department of Nursing, University of Iowa.
    Hidradenitis suppurativa (HS) is a debilitating suppurative disease of the apocrine/follicular glands. Medical treatment has some efficacy in early-stage disease but is costly and requires frequent physician visits. Advanced disease usually requires surgical intervention. Read More

    Collagen-cellulose nanocrystal scaffolds containing curcumin-loaded microspheres on infected full-thickness burns repair.
    J Tissue Eng Regen Med 2017 Mar 22. Epub 2017 Mar 22.
    Guangdong-Hongkong-Macau Institute of CNS Regeneration (GHMICR), Jinan University, Guangzhou, China.
    Burn infection is a serious problem that delays wound healing and leads to death. Curcumin (Cur) has been shown to exhibit antioxidant, anti-inflammatory, antimicrobial and anticarcinogenic activity. However, its instability, extremely low aqueous solubility and bioavailability in physiological fluids may make it difficult to maintain local Cur concentrations above the minimum inhibitory concentration for burn infection treatment. Read More

    Allium stipitatum Extract Exhibits In Vivo Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus and Accelerates Burn Wound Healing in a Full-Thickness Murine Burn Model.
    Evid Based Complement Alternat Med 2017 22;2017:1914732. Epub 2017 Feb 22.
    Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Darul Ehsan, Malaysia.
    The in vivo antibacterial and burn wound healing potency of Persian shallot bulbs (Allium stipitatum) were explored in a mice burn model infected with methicillin-resistant Staphylococcus aureus (MRSA). Hexane (ASHE) and dichloromethane (ASDE) extracts were tested. Female BALB/c mice were inflicted with third-degree thermal injury followed by infection with MRSA. Read More

    Experience and outcomes of micrografting for major paediatric burns.
    Burns 2017 Mar 15. Epub 2017 Mar 15.
    Ross Tilley Burn Centre, Division of Plastic and Reconstructive Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Canada.
    Background: The deficit of donor sites in major burns over 50% of the total body surface area has necessitated the application of methods besides traditional meshed autografting to achieve definitive skin cover. The Meek micrografting technique was introduced at this hospital in 2011, especially in the absence of a reliable source of deceased donor allograft skin. The purpose of this study was to evaluate this strategy with reference to its technical execution, efficacy and indications in the context of major paediatric burn surgery. Read More

    Efficacy of dermal substitute on deep dermal to full thickness burn injury: a systematic review.
    ANZ J Surg 2017 Mar 17. Epub 2017 Mar 17.
    NSW Severe Burn Injury Unit, Concord Repatriation General Hospital, Sydney, New South Wales, Australia.
    Background: The study aims to systematically examine the efficacy of dermal regeneration templates (DRTs) in comparison to split thickness skin grafting (STSG) in the management of acute burn injuries post-excision and debridement.

    Methods: Systematic literature search was conducted by two independent reviewers from the following databases: MEDLINE, EMBASE and Cochrane Library with selection criteria set a priori. Only randomized controlled trials (RCTs) were included. Read More

    An Alternative Treatment Strategy for Complicated Chronic Wounds: Negative Pressure Therapy over Mesh Skin Graft.
    Biomed Res Int 2017 19;2017:8395219. Epub 2017 Feb 19.
    "Valdoni" Surgery Department, Plastic and Reconstructive Surgery Unit, "Sapienza" University of Rome, Viale del Policlinico 155, 00161 Roma, Italy.
    Extensive skin defect represents a real problem and major challenge in plastic and reconstructive surgery. On one hand, skin grafts offer a practical method to deal with skin defects despite their unsuitability for several complicated wounds. On the other hand, negative pressure wound therapy (NPWT), applied before skin grafting, promotes granulation tissue growth. Read More

    Arginine Is a Critical Substrate for the Pathogenesis of Pseudomonas aeruginosa in Burn Wound Infections.
    MBio 2017 Mar 14;8(2). Epub 2017 Mar 14.
    Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    Environmental conditions affect bacterial behavior and can greatly influence the course of an infection. However, the environmental cues that elicit bacterial responses in specific infection sites are relatively unknown. Pseudomonas aeruginosa is ubiquitous in nature and typically innocuous. Read More

    Study on biofilm formation in burn wound infection in a pediatric hospital in Chennai, India.
    Ann Burns Fire Disasters 2016 Dec;29(4):276-280
    Research Department, CHILDS Trust Medical Research Foundation, Chennai, India.
    Infection is one of the major causes of death in pediatric burns in India. This work was conducted in an exclusive Children's Hospital (KKCTH) with a total of 220 beds, of which ten beds in the burn unit and two isolation beds in the 28-bed PICU are for burns patients (more than 20% TBSA burns) with sepsis. In this study, 30 burn wound swab isolates obtained from 14 pediatric burns patients (admitted to the burns ward and transferred to PICU) from November 2013 to March 2014 were investigated. Read More

    Effect of probiotic administration in the therapy of pediatric thermal burn.
    Ann Burns Fire Disasters 2016 Dec;29(4):268-272
    Plastic, Reconstructive Surgery and Burns Department, Tanta Faculty of Medicine, Tanta, Egypt.
    Oral probiotic administration has been advocated for treatment and prevention of a diverse range of disorders. This study was undertaken to evaluate the effect of probiotic supplementation on outcome of pediatric post-burn patients. Forty thermally-injured pediatric patients with total body surface burns between 20-50% and depth between 5-10% were randomized in a prospective, double-blind, controlled clinical trial into two even groups: probiotic group (n=20), who received probiotic preparations, and placebo control group (n=20). Read More

    Fast and specific detection of Pseudomonas Aeruginosa from other pseudomonas species by PCR.
    Ann Burns Fire Disasters 2016 Dec;29(4):264-267
    Department of Biology, Tonekabon Branch, Islamic Azad University, Iran.
    Pseudomonas aeruginosa is an important life-threatening nosocomial pathogen that plays a prominent role in wound infections of burned patients. We designed this study to identify the isolates of P. aeruginosa recovered from burned patients at the genus and species level through primers targeting oprI and oprL genes, and analyzed their antimicrobial resistance pattern. Read More

    Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis.
    Int J Mol Sci 2017 Mar 10;18(3). Epub 2017 Mar 10.
    Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School Hospital, Tokyo 113-8603, Japan.
    Keloids and hypertrophic scars are caused by cutaneous injury and irritation, including trauma, insect bite, burn, surgery, vaccination, skin piercing, acne, folliculitis, chicken pox, and herpes zoster infection. Notably, superficial injuries that do not reach the reticular dermis never cause keloidal and hypertrophic scarring. This suggests that these pathological scars are due to injury to this skin layer and the subsequent aberrant wound healing therein. Read More

    Reactive Oxygen Species Mediated Prostaglandin E2 Contributes to Acute Response of Epithelial Injury.
    Oxid Med Cell Longev 2017 9;2017:4123854. Epub 2017 Feb 9.
    Department of Burns and Plastic Surgery, No. 9 People's Hospital, and Institute of Traumatic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China.
    Reactive oxygen species (ROS) generated after tissue injury play a crucial role during wound healing through initiating acute inflammation, clarifying infection and dead tissue, and mediating various intracellular signal transduction. Prostaglandin E2 (PGE2) has been identified as one of the major factors responsible for inflammation and tissue repair. In this study, we tested our hypothesis that ROS produced by damaged human keratinocytes induces the synthesis of PGE2. Read More

    Molecular-Characterization of Methicillin-Resistance Staphylococcus aureus (MRSA) from Different Tertiary Care Hospitals in Bangladesh.
    Mymensingh Med J 2017 Jan;26(1):37-44
    Dr Sangjukta Roy, Lecturer, Department of Microbiology, Mymensingh Medical College (MMC), Mymensingh, Bangladesh.
    Infections caused by Staphylococcus aureus were treated by methicillin, but about 95% of S. aureus has been resistance to methicillin, both in the community and hospitals and are increasing day by day. MRSA produces altered penicillin binding protein, PBP2a, due to the expression of mecA gene. Read More

    Histopathological assessment of OASIS Ultra on critical-sized wound healing: a pilot study.
    J Cutan Pathol 2017 Jun 23;44(6):523-529. Epub 2017 Mar 23.
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, Massachusetts.
    Background: Dermatopathologists assess wounds secondary to trauma, infection, or oncologic resection that can be challenging to reconstruct. OASIS Ultra, an extracellular matrix, has been described for use in chronic and burn wounds. The aim of this pilot study is to assess wound healing in post-traumatic and infective wounds treated with OASIS using histological markers of repair. Read More

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