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    Utilization of PFGE as a Powerful Discriminative Tool for the Investigation of Genetic Diversity among MRSA Strains.
    Iran J Public Health 2017 Mar;46(3):351-356
    Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant challenge to the burn patient. The implementation of proper monitoring programs and prompt identification of epidemic MRSA strains are critical to consequently control and eradicate potential outbreaks. This study aimed to define the genetic relatedness of MRSA strains isolated from burn patients by analyzing the large fragments of DNA. Read More

    Nutrition and metabolism in burn patients.
    Burns Trauma 2017 17;5:11. Epub 2017 Apr 17.
    University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390 USA.
    Severe burn causes significant metabolic derangements that make nutritional support uniquely important and challenging for burned patients. Burn injury causes a persistent and prolonged hypermetabolic state and increased catabolism that results in increased muscle wasting and cachexia. Metabolic rates of burn patients can surpass twice normal, and failure to fulfill these energy requirements causes impaired wound healing, organ dysfunction, and susceptibility to infection. Read More

    [Advances in the research of treatment of burns in the elderly].
    Zhonghua Shao Shang Za Zhi 2017 Apr;33(4):251-254
    Department of Burns, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
    With our country going into the aging society, burns in the elderly often occur. Studies have shown that the number of elderly burn patients has reached 13% to 20% of the total number of burn patients. As the sensory and cognitive functions are low, skin is thinning, the functions of heart, lung, and kidney are reduced, the immunity is impaired, and other physiological characteristics exist in the elderly, the wounds of elderly burn patients often heal slowly, and the mortality is high. Read More

    Salve and Burdock: A Safe, Effective Amish Remedy for Treatment of Traumatic Wounds?
    Adv Skin Wound Care 2017 May;30(5):213-217
    Mitchell D. Flurry, MD, is Assistant Professor, Plastic Surgery & Aesthetics, Wichita, Kansas. Kelsie L. Herring, BA, Medical Student, graduates to MD in May 2017; Logan W. Carr, MD, is Resident Physician; Randy M. Hauck, MD, is Associate Professor of Surgery; and John D. Potochny, MD, is Associate Professor of Surgery, Pennsylvania State College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania.
    Background: Amish patients show a demonstrated preference for traditional, herbal remedies over modern medical interventions such as skin grafting. One such remedy is a mixture of Burn & Wound Ointment (B & W Ointment; Holistic Acres, LLC; Newcomerstown, Ohio) and steeped burdock leaves. Although both have demonstrated some antimicrobial and wound healing properties, burdock and/or the combination of B & W Ointment and burdock has never been studied to determine its purported ability to reduce pain, prevent infection, and accelerate wound healing. Read More

    In-vitro discrimination of wound associated bacteria by volatile compound profiling using Selected Ion Flow Tube - Mass Spectrometry.
    J Appl Microbiol 2017 Apr 19. Epub 2017 Apr 19.
    University of the West of England Centre for Research in Biosciences, Faculty of Health and Applied Sciences, University of the West of England, Bristol, UK, BS16 1QY.
    Aims: To determine if bacterial species responsible for clinically relevant wound infection produce specific volatile profiles that would allow their speciation.

    Methods And Results: Selected-Ion Flow Tube-Mass Spectrometry in full mass scan mode was used to analyse headspace gases produced by wound-associated bacteria grown in vitro, so as to enable identification of bacterial volatile product ion profiles in the resulting mass spectra. Applying multivariate statistical analysis (hierarchical clustering and principal component analysis) to the resultant mass spectra enabled clear speciation. Read More

    Management of the extensive thoracic defects after deep sternal wound infection with the rectus abdominis myocutaneous flap: A retrospective case series.
    Medicine (Baltimore) 2017 Apr;96(16):e6391
    aDepartment of Burns and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University bXi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
    Deep sternal wound infection is a severe complication after open heart surgery. According to the different severity and dimensions of the deep sternal wound infection, the treatment method is different. In this study, we aimed to describe our experience with the rectus abdominis myocutaneous flap for large sternal wound management, especially when 1 or 2 internal mammary arteries were absent. Read More

    Screening nasal swabs for methicillin resistant Staphylococcus aureus: A regional burn center's experience.
    Burns 2017 Apr 12. Epub 2017 Apr 12.
    The Burn Center, Department of Surgery, MedStar Washington Hospital Center, Washington, DC, United States; Firefighters' Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, DC, United States. Electronic address:
    Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen that can result in substantial morbidity and mortality. Early detection of MRSA colonization by screening nasal swabs may be important in the management of burn-injured patients. However, studies examining its use in this population are limited. Read More

    Lignin-graft-Polyoxazoline Conjugated Triazole a Novel Anti-Infective Ointment to Control Persistent Inflammation.
    Sci Rep 2017 Apr 12;7:46412. Epub 2017 Apr 12.
    Central Research Facility, Rubber Technology Centre, Indian Institute of Technology Kharagpur, Kharagpur 721302, WB, India.
    Lignin, one of the most abundant renewable feedstock, is used to develop a biocompatible hydrogel as anti-infective ointment. A hydrophilic polyoxazoline chain is grafted through ring opening polymerization, possess homogeneous spherical nanoparticles of 10-15 nm. The copolymer was covalently modified with triazole moiety to fortify the antimicrobial and antibiofilm activities. Read More

    Accelerated re-epithelialization of partial-thickness skin wounds by a topical betulin gel: Results of a randomized phase III clinical trials program.
    Burns 2017 Apr 8. Epub 2017 Apr 8.
    Department of Oral and Maxillofacial Surgery/Plastic Surgery, University Medicine Greifswald, Ferdinand-Sauerbruch-Str. DZ7, 17475 Greifswald, Germany.
    The clinical significance of timely re-epithelialization is obvious in burn care, since delayed wound closure is enhancing the risk of wound site infection and extensive scarring. Topical treatments that accelerate wound healing are urgently needed to reduce these sequelae. Evidence from preliminary studies suggests that betulin can accelerate the healing of different types of wounds, including second degree burns and split-thickness skin graft wounds. Read More

    Stochasticity among Antibiotic-Resistance Profiles of Common Burn-Related Pathogens over a Six-Year Period.
    Surg Infect (Larchmt) 2017 Apr 24;18(3):327-335. Epub 2017 Feb 24.
    1 Pritzker School of Medicine, University of Chicago , Chicago, Illinois.
    Background: One of the most significant contributors to morbidity and death in patients with burns is infection, which accounts for 30%-75% of post-burn fatalities. Because of concerns for the development of antibiotic resistance in burn-related pathogens, the aims of this study were to identify antibiotic resistance trends for the four most common burn-related pathogens over a six-year period.

    Patients And Methods: The study used prospectively collected and de-identified aggregate data for all burn patients admitted to the burn unit between 2009 and 2014. Read More

    Cytotoxicity testing of burn wound dressings: first results.
    Cell Tissue Bank 2017 Apr 7. Epub 2017 Apr 7.
    Teaching Department of Burns and Reconstructive Surgery and Central Tissue Bank, Medical Faculty, Comenius University, Bratislava, Slovakia.
    Topical antimicrobial therapy represents an essential part of burn wound care. In order to prevent and treat burn wound infection dressings with antimicrobial properties are applied directly on the wound surface. Not only the infection control but also promotion of healing is very important in burn wound management. Read More

    Norfloxacin and metronidazole topical formulations for effective treatment of bacterial infections and burn wounds.
    Interv Med Appl Sci 2016 Jun;8(2):68-76
    Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo , São Paulo, Brazil.
    Introduction: Our various previous findings have shown the suitability of norfloxacin in the treatment of bacterial infections and burn wounds in alone as well as in combination with Curcuma longa in various topical (ointments, gels, and creams) and transdermal drug delivery systems.

    Aims And Methods: Keeping these facts in consideration, we have made an another attempt to prepare semisolid formulations containing 1% w/w of norfloxacin and metronidazole with different bases like Carbopol, polyethylene glycol, and hydroxypropylmethyl cellulose for effective treatment of bacterial infections and burn wounds. The prepared formulations were evaluated for physicochemical parameters, in vitro drug release, antimicrobial activity, and burn wound healing properties. Read More

    Cutaneous Burn Injury Promotes Shifts in the Bacterial Microbiome in Autologous Donor Skin: Implications for Skin Grafting Outcomes.
    Shock 2017 Mar 31. Epub 2017 Mar 31.
    *Burn & Shock Trauma Research Institute, Loyola University Chicago, Health Sciences Campus, Maywood, IL, USA †Department of Surgery, Loyola University Chicago, Health Sciences Campus, Maywood, IL, USA ‡Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Health Sciences Campus, Maywood, IL, USA §Center for Biomedical Informatics, Loyola University Chicago, Health Sciences Campus, Maywood, IL, USA ¶Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA ||Departments of Dermatology and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
    Introduction: The cutaneous microbiome maintains skin barrier function, regulates inflammation, and stimulates wound healing responses. Burn injury promotes an excessive activation of the cutaneous and systemic immune response directed against commensal and invading pathogens. Skin grafting is the primary method of reconstructing full-thickness burns, and wound infection continues to be a significant complication. Read More

    A 3-Phase Approach for the Management of Upper Extremity Electrical Injuries.
    Hand Clin 2017 May 21;33(2):243-256. Epub 2017 Feb 21.
    Hand Fellowship, Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8238, St Louis, MO 63110, USA. Electronic address:
    Upper extremity electrical injuries present with unique pathophysiologic considerations due to the differing mechanisms of injury produced by the electromagnetic field. The initial phase of treatment consists of recognition of other life-threatening injuries, stabilization of patients, and multisystem resuscitation. The second phase of treatment consists of excising devitalized tissue, appropriate wound care to prevent delayed infection, providing temporary and definitive coverage over vital structures, and preventing contracture and joint stiffness via aggressive therapy. Read More

    Nano-silver-decorated microfibrous eggshell membrane: processing, cytotoxicity assessment and optimization, antibacterial activity and wound healing.
    Sci Rep 2017 Mar 27;7(1):436. Epub 2017 Mar 27.
    Institute of Burn Research, State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, the Third Military Medical University, Chongqing, 400038, China.
    An ideal wound dressing can both promote wound healing and prevent bacterial infection. Here, we report a potential dressing prepared by incorporating an optimized concentration of silver nanoparticles (AgNPs) into the microfibers of a natural eggshell membrane (EM) using environmentally friendly and mussel-inspired dopamine. Briefly, acid-treated EM was used as a porous membrane for polydopamine-reduced AgNPs synthesis. Read More

    Occlusive drainage system for split-thickness skin graft: A prospective randomized controlled trial.
    Burns 2017 Mar 27;43(2):379-387. Epub 2016 Oct 27.
    Division of Plastic and Reconstructive Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan; School of Medicine, National Yang-Ming University, Taipei, Taiwan. Electronic address:
    Background: Split-thickness skin grafts are widely used in reconstruction of large area defects. Conventional postoperative recipient site care includes saline-moistened gauze with a protective layer of petroleum gauze and splints for immobilization. This method causes pain while changing the dressing. Read More

    The ability of selected plant essential oils to enhance the action of recommended antibiotics against pathogenic wound bacteria.
    Burns 2017 Mar 27;43(2):310-317. Epub 2016 Oct 27.
    Department of Allergology and Respiratory Rehabilitation, 2nd Chair of Otolaryngology, Medical University of Lodz, Poland.
    The aim of this work was to characterize the ability of essential oils to support antibiotics against pathogenic bacteria in wounds. Gram-positive and Gram-negative bacteria obtained from wound infections were identified according to standard microbiological methods. Essential oils were analysed by GC-FID-MS. Read More

    Burn Wound Healing and Tissue Engineering.
    J Burn Care Res 2017 May/Jun;38(3):e605-e613
    *Department of Emergency Medicine, Stony Brook University, Stony Brook, New York; and †Department of Surgery, University of Cincinnati, Ohio.
    In 2016 the American Burn Association held a State of the Science conference to help identify burn research priorities for the next decade. The current paper summarizes the work of the sub-committee on Burn Wound Healing and Tissue Engineering. We first present the priorities in wound healing research over the next 10 years. Read More

    Surgical Management of Hidradenitis Suppurativa: A 14-Year Retrospective Review of 98 Consecutive Patients.
    J Burn Care Res 2017 Mar 15. Epub 2017 Mar 15.
    From the *Department of Surgery, University of Iowa; †Department of Surgery, University of Arkansas and Arkansas Children's Hospital, Little Rock; and ‡Department of Nursing, University of Iowa.
    Hidradenitis suppurativa (HS) is a debilitating suppurative disease of the apocrine/follicular glands. Medical treatment has some efficacy in early-stage disease but is costly and requires frequent physician visits. Advanced disease usually requires surgical intervention. Read More

    Collagen-cellulose nanocrystal scaffolds containing curcumin-loaded microspheres on infected full-thickness burns repair.
    J Tissue Eng Regen Med 2017 Mar 22. Epub 2017 Mar 22.
    Guangdong-Hongkong-Macau Institute of CNS Regeneration (GHMICR), Jinan University, Guangzhou, China.
    Burn infection is a serious problem that delays wound healing and leads to death. Curcumin (Cur) has been shown to exhibit antioxidant, anti-inflammatory, antimicrobial and anticarcinogenic activity. However, its instability, extremely low aqueous solubility and bioavailability in physiological fluids may make it difficult to maintain local Cur concentrations above the minimum inhibitory concentration for burn infection treatment. Read More

    Allium stipitatum Extract Exhibits In Vivo Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus and Accelerates Burn Wound Healing in a Full-Thickness Murine Burn Model.
    Evid Based Complement Alternat Med 2017 22;2017:1914732. Epub 2017 Feb 22.
    Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Darul Ehsan, Malaysia.
    The in vivo antibacterial and burn wound healing potency of Persian shallot bulbs (Allium stipitatum) were explored in a mice burn model infected with methicillin-resistant Staphylococcus aureus (MRSA). Hexane (ASHE) and dichloromethane (ASDE) extracts were tested. Female BALB/c mice were inflicted with third-degree thermal injury followed by infection with MRSA. Read More

    Experience and outcomes of micrografting for major paediatric burns.
    Burns 2017 Mar 15. Epub 2017 Mar 15.
    Ross Tilley Burn Centre, Division of Plastic and Reconstructive Surgery, Sunnybrook Health Sciences Centre, University of Toronto, Canada.
    Background: The deficit of donor sites in major burns over 50% of the total body surface area has necessitated the application of methods besides traditional meshed autografting to achieve definitive skin cover. The Meek micrografting technique was introduced at this hospital in 2011, especially in the absence of a reliable source of deceased donor allograft skin. The purpose of this study was to evaluate this strategy with reference to its technical execution, efficacy and indications in the context of major paediatric burn surgery. Read More

    Efficacy of dermal substitute on deep dermal to full thickness burn injury: a systematic review.
    ANZ J Surg 2017 Mar 17. Epub 2017 Mar 17.
    NSW Severe Burn Injury Unit, Concord Repatriation General Hospital, Sydney, New South Wales, Australia.
    Background: The study aims to systematically examine the efficacy of dermal regeneration templates (DRTs) in comparison to split thickness skin grafting (STSG) in the management of acute burn injuries post-excision and debridement.

    Methods: Systematic literature search was conducted by two independent reviewers from the following databases: MEDLINE, EMBASE and Cochrane Library with selection criteria set a priori. Only randomized controlled trials (RCTs) were included. Read More

    An Alternative Treatment Strategy for Complicated Chronic Wounds: Negative Pressure Therapy over Mesh Skin Graft.
    Biomed Res Int 2017 19;2017:8395219. Epub 2017 Feb 19.
    "Valdoni" Surgery Department, Plastic and Reconstructive Surgery Unit, "Sapienza" University of Rome, Viale del Policlinico 155, 00161 Roma, Italy.
    Extensive skin defect represents a real problem and major challenge in plastic and reconstructive surgery. On one hand, skin grafts offer a practical method to deal with skin defects despite their unsuitability for several complicated wounds. On the other hand, negative pressure wound therapy (NPWT), applied before skin grafting, promotes granulation tissue growth. Read More

    Arginine Is a Critical Substrate for the Pathogenesis of Pseudomonas aeruginosa in Burn Wound Infections.
    MBio 2017 Mar 14;8(2). Epub 2017 Mar 14.
    Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, Texas, USA
    Environmental conditions affect bacterial behavior and can greatly influence the course of an infection. However, the environmental cues that elicit bacterial responses in specific infection sites are relatively unknown. Pseudomonas aeruginosa is ubiquitous in nature and typically innocuous. Read More

    Study on biofilm formation in burn wound infection in a pediatric hospital in Chennai, India.
    Ann Burns Fire Disasters 2016 Dec;29(4):276-280
    Research Department, CHILDS Trust Medical Research Foundation, Chennai, India.
    Infection is one of the major causes of death in pediatric burns in India. This work was conducted in an exclusive Children's Hospital (KKCTH) with a total of 220 beds, of which ten beds in the burn unit and two isolation beds in the 28-bed PICU are for burns patients (more than 20% TBSA burns) with sepsis. In this study, 30 burn wound swab isolates obtained from 14 pediatric burns patients (admitted to the burns ward and transferred to PICU) from November 2013 to March 2014 were investigated. Read More

    Effect of probiotic administration in the therapy of pediatric thermal burn.
    Ann Burns Fire Disasters 2016 Dec;29(4):268-272
    Plastic, Reconstructive Surgery and Burns Department, Tanta Faculty of Medicine, Tanta, Egypt.
    Oral probiotic administration has been advocated for treatment and prevention of a diverse range of disorders. This study was undertaken to evaluate the effect of probiotic supplementation on outcome of pediatric post-burn patients. Forty thermally-injured pediatric patients with total body surface burns between 20-50% and depth between 5-10% were randomized in a prospective, double-blind, controlled clinical trial into two even groups: probiotic group (n=20), who received probiotic preparations, and placebo control group (n=20). Read More

    Fast and specific detection of Pseudomonas Aeruginosa from other pseudomonas species by PCR.
    Ann Burns Fire Disasters 2016 Dec;29(4):264-267
    Department of Biology, Tonekabon Branch, Islamic Azad University, Iran.
    Pseudomonas aeruginosa is an important life-threatening nosocomial pathogen that plays a prominent role in wound infections of burned patients. We designed this study to identify the isolates of P. aeruginosa recovered from burned patients at the genus and species level through primers targeting oprI and oprL genes, and analyzed their antimicrobial resistance pattern. Read More

    Keloid and Hypertrophic Scars Are the Result of Chronic Inflammation in the Reticular Dermis.
    Int J Mol Sci 2017 Mar 10;18(3). Epub 2017 Mar 10.
    Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School Hospital, Tokyo 113-8603, Japan.
    Keloids and hypertrophic scars are caused by cutaneous injury and irritation, including trauma, insect bite, burn, surgery, vaccination, skin piercing, acne, folliculitis, chicken pox, and herpes zoster infection. Notably, superficial injuries that do not reach the reticular dermis never cause keloidal and hypertrophic scarring. This suggests that these pathological scars are due to injury to this skin layer and the subsequent aberrant wound healing therein. Read More

    Reactive Oxygen Species Mediated Prostaglandin E2 Contributes to Acute Response of Epithelial Injury.
    Oxid Med Cell Longev 2017 9;2017:4123854. Epub 2017 Feb 9.
    Department of Burns and Plastic Surgery, No. 9 People's Hospital, and Institute of Traumatic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 201900, China.
    Reactive oxygen species (ROS) generated after tissue injury play a crucial role during wound healing through initiating acute inflammation, clarifying infection and dead tissue, and mediating various intracellular signal transduction. Prostaglandin E2 (PGE2) has been identified as one of the major factors responsible for inflammation and tissue repair. In this study, we tested our hypothesis that ROS produced by damaged human keratinocytes induces the synthesis of PGE2. Read More

    Molecular-Characterization of Methicillin-Resistance Staphylococcus aureus (MRSA) from Different Tertiary Care Hospitals in Bangladesh.
    Mymensingh Med J 2017 Jan;26(1):37-44
    Dr Sangjukta Roy, Lecturer, Department of Microbiology, Mymensingh Medical College (MMC), Mymensingh, Bangladesh.
    Infections caused by Staphylococcus aureus were treated by methicillin, but about 95% of S. aureus has been resistance to methicillin, both in the community and hospitals and are increasing day by day. MRSA produces altered penicillin binding protein, PBP2a, due to the expression of mecA gene. Read More

    Histopathological assessment of OASIS ultra on critical-sized wound healing: a pilot study.
    J Cutan Pathol 2017 Mar 2. Epub 2017 Mar 2.
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, Massachusetts.
    Background: Dermatopathologists assess wounds secondary to trauma, infection, or oncologic resection that can be challenging to reconstruct. OASIS Ultra, an extracellular matrix, has been described for use in chronic and burn wounds. The aim of this pilot study is to assess wound healing in post-traumatic and infective wounds treated with OASIS using histological markers of repair. Read More

    Dosing antibiotic prophylaxis during cardiopulmonary bypass-a higher level of complexity? A structured review.
    Int J Antimicrob Agents 2017 Apr 27;49(4):395-402. Epub 2017 Feb 27.
    Centre for Translational Anti-infective Pharmacodynamics, School of Pharmacy, The University of Queensland, Brisbane, Queensland, Australia; Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, Queensland, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Pharmacy Department, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
    In highly invasive procedures such as open heart surgery, the risk of post-operative infection is particularly high due to exposure of the surgical field to multiple foreign devices. Adequate antibiotic prophylaxis is an essential intervention to minimise post-operative morbidity and mortality. However, there is a lack of clear understanding on the adequacy of traditional prophylactic dosing regimens, which are rarely supported by data. Read More

    Partial-thickness burn wounds healing by topical treatment: A randomized controlled comparison between silver sulfadiazine and centiderm.
    Medicine (Baltimore) 2017 Mar;96(9):e6168
    aMedicinal Plants Research Center of Student Basij, Guilan University of Medical Sciences, Rasht bCardiology Department & Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad cPharmacognosy Department and Research and Development Center of Plants and Medicinal Chemistry dFellowship of Burn Surgery, Velayat Hospital eSocial Medicine Department fDermatology Department, Guilan University of Medical Sciences, Rasht, Iran.
    Background: Burns are common event and associated with a high incidence of death, disability, and high costs. Centella asiatica (L.) is a medicinal herb, commonly growing in humid areas in several tropical countries that improve wound healing. Read More

    Myocutaneous Mucormycosis in a Diabetic Burnt Patient Led to Upper Extremity Amputation; A Case Report.
    Bull Emerg Trauma 2017 Jan;5(1):58-62
    Shiraz Burn Research Center, Amir-al-momenin Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
    Mucormycosis is a rare opportunistic fungal infection that can implicate cranial sinuses, brain, lungs, gastrointestinal tract and skin. Although it can occur in patients with competent and incompetent immunity such as patients with diabetes mellitus, lymphoma, leukemia and burns, but it has an aggressive, malignant and lethal course in patients with incompetent immunity. To enforce the importance of burn in patients with underlaying diseases such as diabetes, we are going to report a rare case of diabetic burnt patient complicated by right upper extremity myocutaneous mucormycosis. Read More

    The Effect of Antiseptics on Adipose-Derived Stem Cells.
    Plast Reconstr Surg 2017 Mar;139(3):625-637
    Aachen and Munich, Germany; and New Haven, Conn. From the Department of Plastic and Reconstructive Surgery, Hand Surgery-Burn Center, Medical Faculty, the Institute of Biochemistry and Molecular Cell Biology, RWTH Aachen University; the Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University; the Munich Cluster for Systems Neurology (SyNergy); and the Department of Medicine, Yale University School of Medicine.
    Background: Although chemical antiseptics are the most basic measure to control wound infection and frequently come into contact with subcutaneous adipose tissue, no studies have evaluated their toxicity on adipose tissue and its cell fractions. In the present study, the effects of five different antiseptics on adipose-derived stem cells were evaluated.

    Methods: Human adipose-derived stem cells were harvested from healthy donors. Read More

    Fms-like tyrosine kinase-3 ligand increases resistance to burn wound infection through effects on plasmacytoid dendritic cells.
    BMC Immunol 2017 Feb 22;18(1). Epub 2017 Feb 22.
    Department of Anesthesiology, University of Texas Medical Branch and Shriners Hospitals for Children, 301 University Boulevard, Galveston, TX, 77555-0877, USA.
    Background: Patients experiencing large thermal injuries are susceptible to opportunistic infections that can delay recovery and lead to sepsis. Dendritic cells (DC) are important for the detection of pathogens and activation of the innate and acquired immune responses. DCs are significantly decreased in burn patients early after injury, and the development of sepsis is associated with persistent DC depletion. Read More

    Wound Penetration of Cefazolin, Ciprofloxacin, Piperacillin, Tazobactam, and Vancomycin During Negative Pressure Wound Therapy.
    Adv Wound Care (New Rochelle) 2017 Feb;6(2):55-62
    United States Army Institute of Surgical Research, JBSA Fort Sam Houston, Texas.; Uniformed Services University of the Health Sciences, Bethesda, Maryland.; Infectious Disease Service, Department of Medicine, San Antonio Military Medical Center, JBSA Fort Sam Houston, Texas.
    Objective: Negative pressure wound therapy (NPWT) uses subatmospheric pressure as a noninvasive adjunct to treat wounds and has demonstrated clinical efficacy by accelerating healing of a variety of acute and chronic wounds. NPWT may also play a role in preventing or treating wound infections, possibly by increasing wound penetration of antibiotics. However, clinical data in patients undergoing antibiotic and NPWT treatment are limited. Read More

    A new option for definitive burn wound closure - pair matching type of retrospective case-control study of hand burns in the hospitalised patients group in the Dr Stanislaw Sakiel Centre for Burn Treatment between 2009 and 2015.
    Int Wound J 2017 Feb 21. Epub 2017 Feb 21.
    Department of Biochemistry, Medical University of Silesia in Katowice, School of Medicine with the Division of Dentistry in Zabrze, Zabrze, Poland.
    Nearly 80% of all burns include the hands of affected individuals. Skin grafting is the gold standard in burns treatment, but in the case of the burn wound bed, it may require the necessity of utilising skin substitutes to facilitate closure. The aim of this study is to assess the impact of a porcine-derived wound dressing (Oasis™) for application to hand burns compared to a synthetic dressing (Suprathel™). Read More

    [Advances in the research of antibacterial function of silver nanoparticle and its application in burn treatment].
    Zhonghua Shao Shang Za Zhi 2017 Feb;33(2):121-125
    Department of Burns, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
    Silver has received much attention for its great anti-infection effect in wound. With the development of nanotechnology, the advantages of silver nanoparticles have gradually arisen in scientific practice and clinical application due to their large specific surface area etc. In this article, we conclude the antibacterial mechanisms of silver nanoparticles, the factors influencing their antibacterial effects, the methods of improving their performance and safety, and their application in burn treatment. Read More

    [Influence of collagen/fibroin scaffolds containing silver nanoparticles on dermal regeneration of full-thickness skin defect wound in rat].
    Zhonghua Shao Shang Za Zhi 2017 Feb;33(2):103-110
    Department of Burns, the Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, China.
    Objective: To explore the influence of collagen/fibroin scaffolds containing silver nanoparticles on dermal regeneration of full-thickness skin defect wound in rat. Methods: Eighty-one collagen/fibroin scaffolds containing silver nanoparticles (with the mass concentration of silver nanoparticles as 10 mg/L) and 81 collagen/fibroin scaffolds without silver nanoparticles were produced respectively with freeze-drying method and enrolled as silver nanoparticles scaffold group (SNS) and control scaffold group (CS). Nine scaffolds in each group were cultured with human fibroblasts. Read More

    Clinical Case of the Month: Group G Streptococcal Bacteremia Secondary to a Burn Wound Infection.
    J La State Med Soc 2017 Jan-Feb;169(1):20-23. Epub 2017 Feb 15.
    Louisiana State University Health Sciences Center in New Orleans, LA.
    A 61-year-old man presented to the emergency department with second degree burns along his right arm and hand. He reported that his knees suddenly gave out while holding a pot of soup resulting in the scalding liquid spilling over his arm. His medical history is significant for alcohol abuse, chronic obstructive pulmonary disease, atrial fibrillation, congestive heart failure with preserved ejection fraction, chronic knee instability, and degenerative joint disease of the spine. Read More

    Reconstruction of an Anterior Cervical Necrotizing Fasciitis Defect Using a Biodegradable Polyurethane Dermal Substitute.
    Eplasty 2017 25;17:e3. Epub 2017 Jan 25.
    Adult Burn Centre, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
    Introduction: Although we have previously described the use of a novel polyurethane biodegradable dermal substitute in the reconstruction of 20 free flap donor sites, and extensive cutaneous defects, including a large area of exposed calvarium secondary to burn injury, our experience with this material now extends to 35 free flap donor site reconstructions and 13 major or complex burns. Methods: The polyurethane material (NovoSorb BTM; PolyNovo Biomaterials Pty Ltd, Port Melbourne, Victoria, Australia) was recently employed in another complex wound scenario, implanted into a large anterior cervical cutaneous and soft-tissue defect remaining after serial radical debridement for necrotizing fasciitis. Results: Implantation, integration, delamination, and split-skin graft application proceeded without complication, mirroring our previous experience in other wounds (including major burns). Read More

    Infection in burn patients in a referral center in Colombia.
    Burns 2017 May 6;43(3):642-653. Epub 2017 Feb 6.
    University Hospital of Santander, Universidad Industrial de Santander, Colombia. Electronic address:
    Introduction: Worldwide, burns are responsible for more than 300,000 deaths annually; infection is a major cause of morbidity and mortality in these patients. Early identification and treatment of infection improves outcome. Toward this end it's necessary to identify the institutions flora and organisms that most frequently produces infection. Read More

    Antimicrobial peptide Epinecidin-1 promotes complete skin regeneration of methicillin-resistant Staphylococcus aureus-infected burn wounds in a swine model.
    Oncotarget 2017 Mar;8(13):21067-21080
    Marine Research Station, Institute of Cellular and Organismic Biology, Academia Sinica, Jiaushi, Ilan, Taiwan.
    This report shows that the antimicrobial peptide (AMP) Epinecidin-1 (Epi-1) efficiently heals MRSA-infected heat burn injuries and provides protection from infection in a pig model. The presence of an optimal level of Epi-1 induces cell proliferation by promoting cell cycle progression through an increase in S-phase cells. Epi-1 also induces proliferation to cover the wounded region in an in vitro cell proliferation assay using immortalized human epithelial HaCaT cells. Read More

    On-Demand Dissolution of Chemically Cross-Linked Hydrogels.
    Acc Chem Res 2017 Feb 7;50(2):151-160. Epub 2017 Feb 7.
    Departments of Chemistry, Biomedical Engineering, and Medicine, Boston University , 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
    The formation and subsequent on-demand dissolution of chemically cross-linked hydrogels is of keen interest to chemists, engineers, and clinicians. In this Account, we summarize our recent advances in the area of dissolvable chemically cross-linked hydrogels and provide a comparative discussion of other recent hydrogel systems. Using biocompatible macromonomers, we developed a library of cross-linked dendritic hydrogels that possess favorable properties, including biocompatibility, tissue adhesion, and swelling. Read More

    A systematic review and meta-analysis of clinical outcomes associated with nanocrystalline silver use compared to alternative silver delivery systems in the management of superficial and deep partial thickness burns.
    Burns 2017 Feb 1. Epub 2017 Feb 1.
    Department of Plastic Surgery, Kuopio University Hospital, Kuopio, Finland.
    Objective: The purpose of this systematic review and meta-analysis was to assess the clinical effectiveness of nanocrystalline silver compared to alternative silver delivery systems (silver sulphadiazine [SSD] and silver nitrate) in adults and children with superficial and deep partial thickness burns.

    Methods: PubMed, EMBASE, Cochrane and other databases were searched to identify relevant randomised controlled trials and observational studies.

    Results: Eight studies that assessed both nanocrystalline silver and SSD and one study that compared nanocrystalline silver vs. Read More

    Comparison of clinical outcomes in diabetic and non-diabetic burns patients in a national burns referral centre in southeast Asia: A 3-year retrospective review.
    Burns 2017 Mar 31;43(2):436-444. Epub 2017 Jan 31.
    Department of Anaesthesiology, Singapore General Hospital, Outram Road, Singapore 169608, Singapore. Electronic address:
    Objective: Diabetic burns patients may be at risk of worse clinical outcomes. This study aims to further investigate the impact of diabetes mellitus on clinical outcomes in burns patients in Singapore.

    Methods: A 3-year retrospective review was performed at the Singapore General Hospital Burns Centre (2011-2013). Read More

    Changing trends in antimicrobial susceptibility pattern of bacterial isolates in a burn unit.
    Burns 2017 Jan 30. Epub 2017 Jan 30.
    Department of Microbiology, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dilshad Garden, Delhi-95, India. Electronic address:
    Introduction: Emerging antimicrobial resistance in nosocomial bacterial isolates, limits the available treatment options for burn wound infections, among them multi-drug resistant Gram negative bacteria and methicillin-resistant Staphylococcus aureus (MRSA) are major contributors to the increase in morbidity and mortality rates.

    Material And Methods: A retrospective cross-sectional study was done in the Department of Microbiology, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi. A total of 818 wound samples from patients admitted in the burn wards and Intensive Care Units (ICUs) examined between 2010-2014 (5 years period). Read More

    Evaluation of Metallo-β-Lactamase-Production and Carriage of bla-VIM Genes in Pseudomonas aeruginosa Isolated from Burn Wound Infections in Isfahan.
    Arch Trauma Res 2016 Dec 12;5(4):e34343. Epub 2016 Jun 12.
    Department of Parasitology and Mycology, School of Medicine, Alborz University of Medical Sciences, Karaj, IR Iran.
    Background: Metallo-β-lactamase-production among Gram-negative bacteria, including Pseudomonas aeruginosa, has become a challenge for treatment of infections due to these resistant bacteria.

    Objectives: The aim of the current study was to evaluate the metallo-β-lactamase-production and carriage of bla-VIM genes among carbapenem-resistant P. aeruginosa isolated from burn wound infections. Read More

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