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    Combined vaginoplasty technique for male-to-female sex reassignment surgery: Operative approach and outcomes.
    J Plast Reconstr Aesthet Surg 2017 May 27. Epub 2017 May 27.
    Department of Plastic Surgery, University Teaching Hospital Rotkreuzklinikum München, Munich Technical University, Munich, Germany.
    Background: Several therapy options exist for male-to-female (MTF) transgenders desiring sex reassignment. Surgery includes numerous different procedures. Of those, vaginoplasty is predominant and aims at providing attractive esthetics and fully functional genitals. Read More

    Characterization and in vitro antibacterial activity of saponin-conjugated silver nanoparticles against bacteria that cause burn wound infection.
    World J Microbiol Biotechnol 2017 Jul 20;33(7):147. Epub 2017 Jun 20.
    Department of Biotechnology, Rajalakshmi Engineering College, Thandalam, Chennai, Tamil Nadu, 602 105, India.
    Saponins are glycosides, which destabilize the membrane by altering the membrane permeability. Thus, the present study was aimed to fabricate the silver nanoparticles (AgNPs) using fenugreek derived saponin (SN) against multi-drug resistant bacteria. This study has optimized the concentration of SN (240 mg/mL) for the synthesis of an effective AgNPs against the test organism Escherichia coli. Read More

    Systemic antimicrobial prophylaxis in burn patients: a systematic review.
    J Hosp Infect 2017 Jun 16. Epub 2017 Jun 16.
    Hospital Cosme Argerich, Department of Intensive Care Medicine, Sanatorio Dupuytren, Cesar Diaz 3026, 1416 Buenos Aires, Argentina.
    Objective: To review studies of systemic antibiotic prophylaxis in burn patients.

    Methods: Human clinical trials during the period 1966-2016 where prophylactic systemic antibiotics were compared with placebo or no intervention were identified in electronic databases.

    Results: Nineteen trials met the selection criteria. Read More

    Mouse Model of Burn Wound and Infection: Thermal (Hot Air) Lesion-Induced Immunosuppression.
    Curr Protoc Mouse Biol 2017 Jun 19;7(2):77-87. Epub 2017 Jun 19.
    Department of Clinical Microbiology, Rigshospitalet, Copenhagen, Denmark.
    The immunosuppression induced by thermal injury renders the burned victim susceptible to infection. A mouse model was developed to examine the immunosuppression, which was possible to induce even at a minor thermal insult of 6% total body surface area. After induction of the burn (48 hr) a depression of leukocytes in the peripheral blood was found of the burned mice. Read More

    Lymph node transfer for refractory infectious sites caused by trauma.
    SAGE Open Med Case Rep 2017 2;5:2050313X17711631. Epub 2017 Jun 2.
    Department of Plastic and Reconstructive Surgery, Nadogaya Hospital, Chiba, Japan.
    Objective: In this report, we placed focus on the immunological function of lymph nodes and performed lymph node transfer via a free flap to a site of refractory infection.

    Case And Results: Case 1 describes a 34-year-old male suffering from compound fractures with severe crush injuries and burns in the right ankle joint. A 20 × 15 cm skin defect was observed around the right malleolus medialis, along with denuded tendons with bacterial infection. Read More

    Mechanisms of pyocyanin toxicity and genetic determinants of resistance in Staphylococcus aureus.
    J Bacteriol 2017 Jun 12. Epub 2017 Jun 12.
    Tennessee Valley Healthcare System, US Department of Veterans Affairs, Nashville, TN, USA.
    Pseudomonas aeruginosa and Staphylococcus aureus are commonly isolated from polymicrobial infections, such as wound infections and chronic respiratory infections of persons with cystic fibrosis. Despite their co-isolation, P. aeruginosa produces substances toxic to S. Read More

    Skin grafts from genetically modified α-1,3-galactosyltransferase knockout miniature swine: A functional equivalent to allografts.
    Burns 2017 Jun 8. Epub 2017 Jun 8.
    TBRC Laboratory, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, USA; Division of Plastic and Reconstructive Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
    Burn is associated with a considerable burden of morbidity worldwide. Early excision of burned tissue and skin grafting of the resultant wound has been established as a mainstay of modern burn therapy. However, in large burns, donor sites for autologous skin may be limited. Read More

    Early pathogenic colonisers of acute burn wounds: A retrospective review.
    Burns 2017 Jun 8. Epub 2017 Jun 8.
    Victorian Adult Burns Service, Alfred Hospital, 55 Commercial Road, Melbourne, Victoria, Australia; Department of Surgery, Central Clinical School, Monash University, Victoria, Australia.
    Background: Early excision of burns reduces the incidence of local and systemic infections caused by colonising microorganisms, and reduces mortality and length of hospital stay. Appropriate antibiotic prophylaxis can reduce the risk of postoperative wound infections and skin graft loss. Antibiotic selection should be based on likely pathogens. Read More

    The use of modern dressings in managing split-thickness skin graft donor sites: a single-centre randomised controlled trial.
    J Wound Care 2017 Jun;26(6):281-291
    Professor, Head of the Department; Department of Plastic and Reconstructive Surgery, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Objective: To identify the most appropriate, most suitable and most efficient dressing for split-thickness skin graft (STSG) donor sites. Comparing the wound healing rate, pain severity and duration, as well as the dressing change frequency in four randomised patient groups.

    Methods: A single-centre non-blinded randomised controlled trial was carried out during 2010-2014. Read More

    Silver-containing foam dressings with Safetac: a review of the scientific and clinical data.
    J Wound Care 2017 Jun;26(Sup6a):S1-S32
    Kristina Hamberg has over 10 years of experience of working with the design and development of wound care products, particularly those with antimicrobial properties. During that time, she has become an expert within the areas of microbiology and test method development, as well as infection prevention. Kristina was awarded her MSc in food science in 1997 from the University of Kalmar, Sweden, and in 2002 she was awarded a PhD for microbiological evaluation of novel technologies for food preservation by Chalmers Technical University, Gothenburg, Sweden.
    Background Topical antimicrobials, such as silver dressings, are progressively being used alongside systemic antibiotics to provide adjunctive, antimicrobial therapy to wounds that are clinically infected or at risk of infection. To help improve wound management, dressings that use Safetac soft silicone technology in combination with a silver-impregnated foam dressing material were developed by Mölnlycke Health Care (Gothenburg, Sweden). The range comprises Mepilex Ag, Mepilex Border Ag and Mepilex Transfer Ag. Read More

    New dressing combination for the treatment of partial thickness burn injuries in children.
    Ann Burns Fire Disasters 2017 Mar;30(1):43-46
    Department of Paediatrics, Surgical Unit, University of Pécs, Hungary.
    Burns are among the most common causes of injury in children. Several wound dressings are available to conservatively treat second-degree burns. Seventy-three children were treated with Aquacel Ag foam and Zn-hyaluronon gel to determine their effectiveness on partial thickness burns. Read More

    Prevalence of biofilm producing aerobic bacterial isolates in burn wound infections at a tertiary care hospital in northern India.
    Ann Burns Fire Disasters 2017 Mar;30(1):39-42
    Department of Microbiology, Pt. B D Sharma PGIMS, Rohtak, Haryana, India.
    Burn wounds frequently get infected due to a break in skin integrity and prolonged hospitalization. Microbial flora originating from the patient's own flora colonize and infect the burn wounds. Bacterial biofilms in particular are postulated as the culprit for the development of non-healing burn wounds by inducing chronic inflammation in these patients. Read More

    Utilities of scrotal flap for reconstruction of penile skin defects after severe burn injury.
    Int Urol Nephrol 2017 Jun 6. Epub 2017 Jun 6.
    Department of Burns and Reconstructive Surgery, Xiangya Hospital, Central South University, Xiangya Road No. 87, Changsha, 41008, Hunan, People's Republic of China.
    Objective: In the present study, we aimed to present our experience of an effective two-stage surgical approach using scrotal skin flap for patients with penile skin defects following severe burn injury.

    Materials And Methods: A total of 17 patients with penile skin defects underwent scheduled two-stage reconstruction using scrotal skin flap from January 2004 to October 2016. Patients, who were selected as eligible candidates for scrotal flap, exhibited a wide range of indications, including iatrogenic injuries (e. Read More

    Bacterial cellulose in biomedical applications: A review.
    Int J Biol Macromol 2017 Jun 3;104(Pt A):97-106. Epub 2017 Jun 3.
    Biopol, Chemistry Department, Federal University of Paraná, Curitiba, PR 81531-980, Brazil. Electronic address:
    Bacterial cellulose (BC) derived materials represents major advances to the current regenerative and diagnostic medicine. BC is a highly pure, biocompatible and versatile material that can be utilized in several applications - individually or in the combination with different components (e.g. Read More

    Bio-inspired crosslinking and matrix-drug interactions for advanced wound dressings with long-term antimicrobial activity.
    Biomaterials 2017 Sep 26;138:153-168. Epub 2017 May 26.
    Anti-Infectives Research Group, Singapore Eye Research Institute, The Academia, 20 College Road, Discovery Tower, Singapore, 169856, Singapore; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Graduate Medical School, Singapore, 169857, Singapore. Electronic address:
    There is a growing demand for durable advanced wound dressings for the management of persistent infections after deep burn injuries. Herein, we demonstrated the preparation of durable antimicrobial nanofiber mats, by taking advantage of strong interfacial interactions between polyhydroxy antibiotics (with varying number of OH groups) and gelatin and their in-situ crosslinking with polydopamine (pDA) using ammonium carbonate diffusion method. Polydopamine crosslinking did not interfere with the antimicrobial efficacy of the loaded antibiotics. Read More

    Even Better Than the Real Thing? Xenografting in Pediatric Patients with Scald Injury.
    Clin Plast Surg 2017 Jul 26;44(3):651-656. Epub 2017 Apr 26.
    Department of Surgery, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA. Electronic address:
    This article reviews a single burn center experience with porcine xenografts to treat pediatric scald injuries, over a 10-year period. The authors compare xenografting to autografting, as well as wound care only, and provide outcome data on length of stay, incidence of health care-associated infections, and need for reconstructive surgery. Read More

    Skin Substitutes and Bioscaffolds: Temporary and Permanent Coverage.
    Clin Plast Surg 2017 Jul 1;44(3):627-634. Epub 2017 Apr 1.
    Plastic Surgery Center of Asheville, 5 Livingston Street, Asheville, NC 28801, USA. Electronic address:
    Advancements in surgical wound treatment have led to skin substitutes and bioscaffolds as temporary and permanent coverage for burn wounds. Skin substitutes are used to improve wound coverage and restore the functional and aesthetic qualities of skin, and help to prevent wound infection and maintain a moist wound healing environment. Although allografts are preferred when autografts are not possible, high costs and limited availability have led to the use of xenografts and the development of skin substitutes and bioscaffolds. Read More

    The progress of Chinese burn medicine from the Third Military Medical University-in memory of its pioneer, Professor Li Ao.
    Burns Trauma 2017 30;5:16. Epub 2017 May 30.
    Institute of Burn Research, State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, Third Military Medical University, Gaotanyan Street no.29, Shapingba District, Chongqing, 400038 China.
    Professor Li Ao was one of the founders of Chinese burn medicine and one of the most renowned doctors and researchers of burns in China. He established one of the Chinese earliest special departments for burns at Third Military Medical University (TMMU) in 1958. To memorialize Professor Li Ao on his 100th birthday in 2017 and introduce our extensive experience, it is our honor to briefly review the development and achievement of the Chinese burn medicine from TMMU. Read More

    Outcomes of Geriatric Burns Treated as Outpatients.
    Ann Plast Surg 2017 May 31. Epub 2017 May 31.
    From the Department of Emergency Medicine, Fukui Prefectural Hospital, Fukui, Japan.
    Objective: Most literature about geriatric burns has focused on inpatient management; therefore, our study investigated the effects of burn characteristics and preexisting medical comorbidities on treatment outcomes for geriatric burn patients treated as outpatients.

    Methods: A retrospective review was conducted for 391 patients over 65 years of age seen in the emergency department of Fukui Prefectural Hospital over a 10-year period. Charts were reviewed for age, sex, burn characteristics, burn mechanisms, preexisting medical comorbidities, and treatment outcomes. Read More

    Highly effective Cu/Zn-carbon micro/nanofiber-polymer nanocomposite-based wound dressing biomaterial against the P. aeruginosa multi- and extensively drug-resistant strains.
    Mater Sci Eng C Mater Biol Appl 2017 Aug 31;77:630-641. Epub 2017 Mar 31.
    Department of Bioscience and Biotechnology, Banasthali University, Banasthali, 304022, India.
    Pseudomonas aeruginosa (P. aeruginosa) is the most prevalent bacteria in the infections caused by burn, surgery, and traumatic injuries. Emergence of the P. Read More

    The use of Biobrane(®) for wound coverage in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.
    Burns 2017 May 16. Epub 2017 May 16.
    Ross Tilley Burn Centre, Toronto, Canada. Electronic address:
    Introduction: Published experience describing the use of Biobrane(®) for wound management in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis (SJS-TEN) is limited to case reports and case series involving ten or fewer patients. We have used Biobrane(®) in the care of SJS-TEN since 2000, and the purpose of this study was to review our experience with the application of Biobrane(®) for wound coverage in SJS-TEN.

    Methods: A retrospective review of all cases of SJS-TEN admitted to an adult regional ABA-verified burn center between January 1, 2000 and June 1, 2015 was conducted. Read More

    The Role of Phytochemicals in the Inflammatory Phase of Wound Healing.
    Int J Mol Sci 2017 May 16;18(5). Epub 2017 May 16.
    Department of Surgery, University of Toronto, Toronto, ON M5S 1A8, Canada.
    Historically, plant-based products have been the basis of medicine since before the advent of modern Western medicine. Wound dressings made of honey, curcumin and other phytochemical-rich compounds have been traditionally used. Recently, the mechanisms behind many of these traditional therapies have come to light. Read More

    A Retrospective Chart Review of Chronic Wound Patients Treated with Topical Oxygen Therapy.
    Adv Wound Care (New Rochelle) 2017 May;6(5):143-152
    Angie Purvis, LLC, Evergreen, Colorado.
    Objective: Topical oxygen devices are Food and Drug Administration (FDA) cleared for the following indications for use of various etiologies: skin ulcerations due to diabetes, venous stasis, postsurgical infections and gangrenous lesions, decubitus ulcers; amputations/infected stumps; skin grafts; burns; and frostbite. The goal of this study was to understand the impact of topical oxygen therapy (TOT) on patient outcomes, including amputation and healing rates. Approach: This retrospective chart review included records collected between January 1, 2007, and July 18, 2016, from male and female patients ranging in age from 4 years to 105 years. Read More

    Antibacterial efficacy of poly(vinyl alcohol) composite nanofibers embedded with silver-anchored silica nanoparticles.
    J Biomed Mater Res B Appl Biomater 2017 May 15. Epub 2017 May 15.
    Nano Fusion Technology Research Lab, Division of Frontier Fibers, Institute for Fiber Engineering (IFES), Interdisciplinary Cluster for Cutting Edge Research (ICCER), Shinshu University 3-15-1, Tokida, Ueda, Nagono, 386-8567, Japan.
    Silver has been widely used as an effective antibacterial agent especially for treating burns and wounds. However, release of silver from materials often arouse side effects due to toxicity of silver towards mammalian cells. Argyria and argyrosis are well known problems of acute toxicity of silver towards human body. Read More

    Wound Healing Property Review of Siam Weed, Chromolaena odorata.
    Pharmacogn Rev 2017 Jan-Jun;11(21):35-38
    Department of Pathobiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
    Chromolaena odorata (Family: Asteraceae) synonyms as Eupatorium odoratum is a traditional medicinal plant that is widely used for its wound healing property. In particular, the several parts of this herb have been used to treat wounds, burns, and skin infections. Furthermore, it has also been shown to possess anticancer, antidiabetic, anti-hepatotoxic, anti-inflammatory, antimicrobial, and antioxidant properties. Read More

    Liposome loaded phage cocktail: Enhanced therapeutic potential in resolving Klebsiella pneumoniae mediated burn wound infections.
    Burns 2017 May 11. Epub 2017 May 11.
    Department of Microbiology, Panjab University, Chandigarh 160014, India. Electronic address:
    Background: Klebsiella pneumoniae is one of the predominant pathogens in burn wound infections, and prevalence of multidrug resistant strains has further complicated the situation. An increased interest in phage therapy as a means of combating infection has been accruing in recent years. In order to overcome the drawbacks associated with phage therapy, the present study was conducted to evaluate the potential of liposomes as a delivery vehicle for phage in the treatment of burn wound infection. Read More

    Acinetobacter baumannii quorum-sensing signalling molecule induces the expression of drug-resistance genes.
    Mol Med Rep 2017 Jun 28;15(6):4061-4068. Epub 2017 Apr 28.
    Department of Burns and Plastic Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, P.R. China.
    Quorum-sensing signalling molecules such as N‑acyl homoserine lactones (AHLs) enable certain Gram‑negative bacteria to respond to environmental changes through behaviours, such as biofilm formation and flagellar movement. The present study aimed to identify Acinetobacter baumannii AHLs and assess their influence on antibiotic resistance. A clinical isolate of A. Read More

    A 27-Year Follow-Up for a Patient With 100% Total Body Surface Area Burn.
    J Burn Care Res 2017 May 8. Epub 2017 May 8.
    From the *Department of Burns and Wound Care Center, Second Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, China.
    Patients suffering from severe 100% TBSA burns are particularly vulnerable to infection and multiple organ dysfunction syndrome, being on high risks of poor outcomes. Treatment of these patients remains to be a great challenge for burn physicians, and survivors of 100% TBSA burns generally have poor quality of life after burn. Since, to our knowledge, this is the first case report on the long-term follow-up of a 100% TBSA burn survivor, the authors are presenting the initial injury, treatment, and follow-up of this female patient during 27 years. Read More

    Histopathological comparisons of Staphylococcus aureus and Pseudomonas aeruginosa experimental infected porcine burn wounds.
    Wound Repair Regen 2017 May 2. Epub 2017 May 2.
    Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio.
    Chronic skin wounds are a significant human health concern and are often complicated by infection with Pseudomonas aeruginosa and Staphylococcus aureus, particularly methicillin resistant S. aureus (MRSA). Translating the knowledge gained from extensive study of virulence mechanisms and pathogenesis of these bacterial species to new treatment modalities has been lacking in part due to a paucity of animal models able to recapitulate human disease. Read More

    Characterization of Mycobacterium marinum Infections in Zebrafish Wounds and Sinus Tracts.
    Wound Repair Regen 2017 May 2. Epub 2017 May 2.
    Department of Burns and Plastic Surgery, The 309th Hospital of PLA, No. 17, Heishanhu Street, Beijing, 100091, China.
    The impaired healing of Mycobacterium tuberculosis-infected wounds is a clinical challenge, and the mechanisms involved are still not clear. The zebrafish model of Mycobacterium marinum infection has provided surprising insights into the pathogenesis of tuberculosis in humans. Similarly, the major principles and phases of cutaneous wound healing are conserved among adult mammals and adult zebrafish. Read More

    [Advance on human umbilical cord mesenchymal stem cells for treatment of ALI in severe burns].
    Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2017 Jan;29(1):90-96
    Graduate School, Jinzhou Medical University, Jinzhou 121000, Liaoning, China (Wang Y); Department of Pediatrics, the First Affiliated Hospital to PLA General Hospital, Beijing 100048, China (Hu XH). Corresponding author: Hu Xiaohong, Email:
    Objective: Severe burn is often accompanied by multiple organ damage. Acute lung injury (ALI) is one of the most common complications, and often occurs in the early stage of severe burns. If it is not treated in time, it will progress to acute respiratory distress syndrome (ARDS), which will be a serious threat to the lives of patients. Read More

    Surgical treatment and management of the severely burn patient: Review and update.
    Med Intensiva 2017 Apr 26. Epub 2017 Apr 26.
    Plastic Surgeon, Plastic and Reconstructive Department, Burns Unit, Virgen del Rocio University Hospital, Sevilla, Spain. Electronic address:
    Since one of the main challenges in treating acute burn injuries is preventing infection, early excising of the eschar and covering of the wound becomes critical. Non-viable tissue is removed by initial aggressive surgical debridement. Many surgical options for covering the wound bed have been described, although split-thickness skin grafts remain the standard for the rapid and permanent closure of full-thickness burns. Read More

    Are anaerobes a major, underappreciated cause of necrotizing infections?
    Anaerobe 2017 Jun 24;45:65-70. Epub 2017 Apr 24.
    Departments of Surgery, Texas Tech University Health Sciences Center, Lubbock, TX, United States; Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, TX, United States; TTUHSC Surgery Burn Center of Research Excellence, Texas Tech University Health Sciences Center, Lubbock, TX, United States. Electronic address:
    Necrotizing soft tissue infections (NSTIs) are the most severe and rapidly progressing class of skin and soft tissue infections (SSTIs). They are a surgical emergency and are associated with high mortality and morbidity. While NSTIs remain relatively rare, their incidence is steadily rising. Read More

    The Use of the MolecuLight i: X in Managing Burns: A Pilot Study.
    J Burn Care Res 2017 Apr 21. Epub 2017 Apr 21.
    From the *University College London, United Kingdom; †Queen Elizabeth Hospital Birmingham, United Kingdom; and ‡Birmingham Burn Centre, The Queen Elizabeth Hospital, United Kingdom.
    The MolecuLight i:X Imaging Device is a portable, noninvasive, real-time camera used to visualize the bacterial load in a wound. It uses violet light illumination and a dual bandpass optical filter to capture the fluorescence of endogenous structures in the tissue matrix and harmful bacteria. The MolecuLight i:X captures images of wounds and highlights potentially detrimental levels of bacteria. Read More

    Is antibiotic prophylaxis in breast augmentation necessary? A prospective study.
    Plast Surg (Oakv) 2016 19;24(3):195-198. Epub 2016 Aug 19.
    Kosmesis Aesthetic Plastic Surgery Centre, Athens, Greece.
    Background: The role of prophylactic antibiotics in breast augmentation remains controversial. However, the majority of surgeons are administering antibiotics.

    Objective: To investigate the effect of antibiotic(s) use in the incidence of infection and capsular contracture following breast augmentation. Read More

    Evaluation of a new tension relief system for securing wound closure: A single-centre, Chinese cohort study.
    Plast Surg (Oakv) 2016 19;24(3):177-182. Epub 2016 Aug 19.
    Department of Plastic Surgery, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hang Zhou, People's Republic of China.
    Background: Wounds that have been closed under excessive tension, and skin defects that cannot be closed primarily, pose a daily challenge for the reconstructive surgeon.

    Objective: To evaluate a new tension relief system (TRS) device for skin stretching and secure wound closure.

    Methods: From September 2013 to March 2014, a consecutive series of 41 Chinese patients with 43 wounds were enrolled for application of 50 cycles of TRS therapy. Read More

    Utilization of PFGE as a Powerful Discriminative Tool for the Investigation of Genetic Diversity among MRSA Strains.
    Iran J Public Health 2017 Mar;46(3):351-356
    Biotechnology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant challenge to the burn patient. The implementation of proper monitoring programs and prompt identification of epidemic MRSA strains are critical to consequently control and eradicate potential outbreaks. This study aimed to define the genetic relatedness of MRSA strains isolated from burn patients by analyzing the large fragments of DNA. Read More

    Nutrition and metabolism in burn patients.
    Burns Trauma 2017 17;5:11. Epub 2017 Apr 17.
    University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390 USA.
    Severe burn causes significant metabolic derangements that make nutritional support uniquely important and challenging for burned patients. Burn injury causes a persistent and prolonged hypermetabolic state and increased catabolism that results in increased muscle wasting and cachexia. Metabolic rates of burn patients can surpass twice normal, and failure to fulfill these energy requirements causes impaired wound healing, organ dysfunction, and susceptibility to infection. Read More

    [Advances in the research of treatment of burns in the elderly].
    Zhonghua Shao Shang Za Zhi 2017 Apr;33(4):251-254
    Department of Burns, the First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
    With our country going into the aging society, burns in the elderly often occur. Studies have shown that the number of elderly burn patients has reached 13% to 20% of the total number of burn patients. As the sensory and cognitive functions are low, skin is thinning, the functions of heart, lung, and kidney are reduced, the immunity is impaired, and other physiological characteristics exist in the elderly, the wounds of elderly burn patients often heal slowly, and the mortality is high. Read More

    Salve and Burdock: A Safe, Effective Amish Remedy for Treatment of Traumatic Wounds?
    Adv Skin Wound Care 2017 May;30(5):213-217
    Mitchell D. Flurry, MD, is Assistant Professor, Plastic Surgery & Aesthetics, Wichita, Kansas. Kelsie L. Herring, BA, Medical Student, graduates to MD in May 2017; Logan W. Carr, MD, is Resident Physician; Randy M. Hauck, MD, is Associate Professor of Surgery; and John D. Potochny, MD, is Associate Professor of Surgery, Pennsylvania State College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania.
    Background: Amish patients show a demonstrated preference for traditional, herbal remedies over modern medical interventions such as skin grafting. One such remedy is a mixture of Burn & Wound Ointment (B & W Ointment; Holistic Acres, LLC; Newcomerstown, Ohio) and steeped burdock leaves. Although both have demonstrated some antimicrobial and wound healing properties, burdock and/or the combination of B & W Ointment and burdock has never been studied to determine its purported ability to reduce pain, prevent infection, and accelerate wound healing. Read More

    In-vitro discrimination of wound associated bacteria by volatile compound profiling using Selected Ion Flow Tube - Mass Spectrometry.
    J Appl Microbiol 2017 Apr 19. Epub 2017 Apr 19.
    University of the West of England Centre for Research in Biosciences, Faculty of Health and Applied Sciences, University of the West of England, Bristol, UK, BS16 1QY.
    Aims: To determine if bacterial species responsible for clinically relevant wound infection produce specific volatile profiles that would allow their speciation.

    Methods And Results: Selected-Ion Flow Tube-Mass Spectrometry in full mass scan mode was used to analyse headspace gases produced by wound-associated bacteria grown in vitro, so as to enable identification of bacterial volatile product ion profiles in the resulting mass spectra. Applying multivariate statistical analysis (hierarchical clustering and principal component analysis) to the resultant mass spectra enabled clear speciation. Read More

    Management of the extensive thoracic defects after deep sternal wound infection with the rectus abdominis myocutaneous flap: A retrospective case series.
    Medicine (Baltimore) 2017 Apr;96(16):e6391
    aDepartment of Burns and Cutaneous Surgery, Xijing Hospital, The Fourth Military Medical University bXi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, China.
    Deep sternal wound infection is a severe complication after open heart surgery. According to the different severity and dimensions of the deep sternal wound infection, the treatment method is different. In this study, we aimed to describe our experience with the rectus abdominis myocutaneous flap for large sternal wound management, especially when 1 or 2 internal mammary arteries were absent. Read More

    Screening nasal swabs for methicillin resistant Staphylococcus aureus: A regional burn center's experience.
    Burns 2017 Jun 12;43(4):771-779. Epub 2017 Apr 12.
    The Burn Center, Department of Surgery, MedStar Washington Hospital Center, Washington, DC, United States; Firefighters' Burn and Surgical Research Laboratory, MedStar Health Research Institute, Washington, DC, United States. Electronic address:
    Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen that can result in substantial morbidity and mortality. Early detection of MRSA colonization by screening nasal swabs may be important in the management of burn-injured patients. However, studies examining its use in this population are limited. Read More

    Lignin-graft-Polyoxazoline Conjugated Triazole a Novel Anti-Infective Ointment to Control Persistent Inflammation.
    Sci Rep 2017 Apr 12;7:46412. Epub 2017 Apr 12.
    Central Research Facility, Rubber Technology Centre, Indian Institute of Technology Kharagpur, Kharagpur 721302, WB, India.
    Lignin, one of the most abundant renewable feedstock, is used to develop a biocompatible hydrogel as anti-infective ointment. A hydrophilic polyoxazoline chain is grafted through ring opening polymerization, possess homogeneous spherical nanoparticles of 10-15 nm. The copolymer was covalently modified with triazole moiety to fortify the antimicrobial and antibiofilm activities. Read More

    Accelerated re-epithelialization of partial-thickness skin wounds by a topical betulin gel: Results of a randomized phase III clinical trials program.
    Burns 2017 Apr 8. Epub 2017 Apr 8.
    Department of Oral and Maxillofacial Surgery/Plastic Surgery, University Medicine Greifswald, Ferdinand-Sauerbruch-Str. DZ7, 17475 Greifswald, Germany.
    The clinical significance of timely re-epithelialization is obvious in burn care, since delayed wound closure is enhancing the risk of wound site infection and extensive scarring. Topical treatments that accelerate wound healing are urgently needed to reduce these sequelae. Evidence from preliminary studies suggests that betulin can accelerate the healing of different types of wounds, including second degree burns and split-thickness skin graft wounds. Read More

    Stochasticity among Antibiotic-Resistance Profiles of Common Burn-Related Pathogens over a Six-Year Period.
    Surg Infect (Larchmt) 2017 Apr 24;18(3):327-335. Epub 2017 Feb 24.
    1 Pritzker School of Medicine, University of Chicago , Chicago, Illinois.
    Background: One of the most significant contributors to morbidity and death in patients with burns is infection, which accounts for 30%-75% of post-burn fatalities. Because of concerns for the development of antibiotic resistance in burn-related pathogens, the aims of this study were to identify antibiotic resistance trends for the four most common burn-related pathogens over a six-year period.

    Patients And Methods: The study used prospectively collected and de-identified aggregate data for all burn patients admitted to the burn unit between 2009 and 2014. Read More

    Cytotoxicity testing of burn wound dressings: first results.
    Cell Tissue Bank 2017 Jun 7;18(2):143-151. Epub 2017 Apr 7.
    Teaching Department of Burns and Reconstructive Surgery and Central Tissue Bank, Medical Faculty, Comenius University, Bratislava, Slovakia.
    Topical antimicrobial therapy represents an essential part of burn wound care. In order to prevent and treat burn wound infection dressings with antimicrobial properties are applied directly on the wound surface. Not only the infection control but also promotion of healing is very important in burn wound management. Read More

    Norfloxacin and metronidazole topical formulations for effective treatment of bacterial infections and burn wounds.
    Interv Med Appl Sci 2016 Jun;8(2):68-76
    Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo , São Paulo, Brazil.
    Introduction: Our various previous findings have shown the suitability of norfloxacin in the treatment of bacterial infections and burn wounds in alone as well as in combination with Curcuma longa in various topical (ointments, gels, and creams) and transdermal drug delivery systems.

    Aims And Methods: Keeping these facts in consideration, we have made an another attempt to prepare semisolid formulations containing 1% w/w of norfloxacin and metronidazole with different bases like Carbopol, polyethylene glycol, and hydroxypropylmethyl cellulose for effective treatment of bacterial infections and burn wounds. The prepared formulations were evaluated for physicochemical parameters, in vitro drug release, antimicrobial activity, and burn wound healing properties. Read More

    Cutaneous Burn Injury Promotes Shifts in the Bacterial Microbiome in Autologous Donor Skin: Implications for Skin Grafting Outcomes.
    Shock 2017 Mar 31. Epub 2017 Mar 31.
    *Burn & Shock Trauma Research Institute, Loyola University Chicago, Health Sciences Campus, Maywood, IL, USA †Department of Surgery, Loyola University Chicago, Health Sciences Campus, Maywood, IL, USA ‡Department of Public Health Sciences, Stritch School of Medicine, Loyola University Chicago, Health Sciences Campus, Maywood, IL, USA §Center for Biomedical Informatics, Loyola University Chicago, Health Sciences Campus, Maywood, IL, USA ¶Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA ||Departments of Dermatology and Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
    Introduction: The cutaneous microbiome maintains skin barrier function, regulates inflammation, and stimulates wound healing responses. Burn injury promotes an excessive activation of the cutaneous and systemic immune response directed against commensal and invading pathogens. Skin grafting is the primary method of reconstructing full-thickness burns, and wound infection continues to be a significant complication. Read More

    A 3-Phase Approach for the Management of Upper Extremity Electrical Injuries.
    Hand Clin 2017 May 21;33(2):243-256. Epub 2017 Feb 21.
    Hand Fellowship, Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8238, St Louis, MO 63110, USA. Electronic address:
    Upper extremity electrical injuries present with unique pathophysiologic considerations due to the differing mechanisms of injury produced by the electromagnetic field. The initial phase of treatment consists of recognition of other life-threatening injuries, stabilization of patients, and multisystem resuscitation. The second phase of treatment consists of excising devitalized tissue, appropriate wound care to prevent delayed infection, providing temporary and definitive coverage over vital structures, and preventing contracture and joint stiffness via aggressive therapy. Read More

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