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    4645 results match your criteria Burn Wound Infections

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    Efficacy of a gel containing polihexanide and betaine in deep partial and full thickness burns requiring split-thickness skin grafts: A non-comparative clinical study.
    J Burn Care Res 2018 Apr 14. Epub 2018 Apr 14.
    Department of Plastic and Hand Surgery, UniversityCenter for Orthopaedics and Trauma Surgery, Universitätsklinikum Carl Gustav Carus Dresden, Dresden, Germany.
    Background: Despite overall advances in burn therapy, wound infection remains one of the leading causes of morbidity and mortality in patients with severe burn injuries. This prospective, multicenter, non-comparative clinical trial was conducted to assess the efficacy and safety of Prontosan® Wound Gel X (PWX), a gel containing polihexanide and betaine, for moistening and cleansing in deep tissue burn wounds requiring split-thickness skin grafting.

    Methods: Patients with deep partial or full thickness burn wounds requiring split-thickness skin grafting were treated with the gel to evaluate its tolerability and safety as well as graft take and the healing of the skin graft. Read More

    Lectin functionalized composite hydrogels for "capture-and-killing" of carbapenem-resistant Pseudomonas aeruginosa.
    Biomacromolecules 2018 Apr 17. Epub 2018 Apr 17.
    Infections with multi-resistant pathogens are a leading cause for mortality worldwide. Just recently, the world health organization (WHO) increased the threat rating for multi-resistant Pseudomonas aeruginosa to the highest possible level. With this background it is crucial to develop novel materials and procedures in the fight against multi-resistant pathogens. Read More

    Development of a contaminated ischemic porcine wound model and the evaluation of bromelain based enzymatic debridement.
    Burns 2018 Apr 13. Epub 2018 Apr 13.
    Mediwound Ltd., Yavneh, Israel; Department of Plastic and Reconstructive Surgery, Ben Gurion University, Beer-Sheba, Israel.
    Objectives: There are no well accepted animal models of chronic wounds, limiting advances in understanding and treatment of chronic ulcers. We developed a porcine wound model which combines multiple factors involved in chronic wounds to create a contaminated necrotic eschar and evaluated the debriding efficacy of a novel bromelain based enzymatic debriding agent (EscharEx).

    Methods: Contaminated ischemic wounds were created on the flanks of domestic pigs by 'sandwiching' the skin between 2 'O' rings (1 placed on the surface of the skin and the other underneath the skin) for 24h prior to dermatomal excision of the necrotic eschar and its contamination with Staphylococcus aureus and Candida albicans. Read More

    Traditional culture methods fail to detect principle pathogens in necrotising soft tissue infection: a case report.
    J Wound Care 2018 Apr;27(Sup4):S24-S28
    Department of Surgery, Texas Tech University Health Sciences Center, TTUHSC Burn Center of Research Excellence, Texas Tech University Health Sciences Center.
    Objective: Necrotising soft tissue infections (NSTIs) progress rapidly and mortality remains high, ranging from 10% to 30%, representing a significant challenge for health professionals. Early accurate diagnosis is crucial because timely and aggressive surgical intervention remains the number one indicator for a better clinical outcome. Understanding the microbial background of NSTIs would aid early diagnosis. Read More

    Impact of anaemia on outcome in burn patients.
    Anaesthesiol Intensive Ther 2018 ;50(1):11-19
    Department of Anesthesiology, University of Florida College of Medicine.
    Background: Currently, most critical care physicians maintain a patient's haemoglobin levels at 7 to 8 g dL-1. However, little data have been available on haemoglobin-related outcomes in burn patients. The purpose of this study was to evaluate inpatients with greater than 20% total body surface area burns and the effects of haemoglobin below 8 g dL-1 on clinical outcomes. Read More

    Autofluorescence Imaging for Evaluating Debridement in Military and Trauma Wounds.
    Mil Med 2018 Mar;183(suppl_1):429-432
    Birmingham Burn Centre, The Queen Elizabeth Hospital, Mindelsohn Way, Birmingham, B15 2TH, UK.
    Background: Mechanisms for military injury have evolved in the past century. Debridement is the gold standard for preparing a clean wound bed, decreasing the bacterial load, and reducing the likelihood of infection. However, bacteria may continue to linger in these wounds. Read More

    Treatment of toxic epidermal necrolysis by a multidisciplinary team. A review of literature and treatment results.
    Burns 2018 Apr 4. Epub 2018 Apr 4.
    Department of Dermatology and Skin Science, University of British Columbia, Canada.
    Background: Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are mucocutaneous hypersensitivity reactions, usually to drugs or their metabolites. TEN is the most severe involving greater than 30% of the total body surface area (TBSA). Management of these patients usually benefits from a large multidisciplinary team for both wound and medical management. Read More

    Sternal Reconstruction with the Omental Flap-Acute and Late Complications, Predictors of Mortality, and Quality of Life.
    J Reconstr Microsurg 2018 Apr 6. Epub 2018 Apr 6.
    Department of Hand-, Plastic, Reconstructive and Burn Surgery, BG Trauma Center Tuebingen, Eberhard Karls University, Tuebingen, Germany.
    Background:  The omental flap is a reliable flap for the coverage of sternal defects. However, little is known about the predictors of mortality and the long-term outcome in such patients.

    Methods:  We, therefore, performed a retrospective study from 2002 to 2013, including all patients that underwent sternal reconstruction with the omental flap. Read More

    L. inermis-loaded nanofibrous scaffolds for wound dressing applications.
    Tissue Cell 2018 Apr 21;51:32-38. Epub 2018 Feb 21.
    Department of Hematology, Faculty of Medical Sciences, Tarbiat Modarres University, Tehran, 14115-111, Iran. Electronic address:
    Since ancient times, some herbal medicines have been extensively used for burn and wound treatments, showing preference to the common synthetic medications by virtue of having less side effects and faster healing rate. In this study, hybrid nanofibrous scaffolds of poly-l-lactic-acid (PLLA) and gelatin incorporated L. inermis were fabricated via electrospinning technique. Read More

    Acetic acid dressings: Finding the Holy Grail for infected wound management.
    Indian J Plast Surg 2017 Sep-Dec;50(3):273-280
    Department of Microbiology, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India.
    Background: Wounds have since long, contributed majorly to the health-care burden. Infected long-standing non-healing wounds place many demands on the treating surgeon and are devastating for the patients physically, nutritionally, vocationally, financially, psychologically and socially. Acetic acid has long been included among agents used in the treatment of infected wounds. Read More

    Staphylopine, pseudopaline and yersinopine dehydrogenases: a structural and kinetic analysis of a new functional class of opine dehydrogenase.
    J Biol Chem 2018 Apr 4. Epub 2018 Apr 4.
    Molecular Biosciences, University of Kansas, United States.
    Opine dehydrogenases (ODH) from the bacterial pathogens , , and perform the final enzymatic step in the biosynthesis of a new class of opine metallophores, which includes staphylopine, pseudopaline, and yersinopine, respectively. Growing evidence indicates the important role of this pathway in metal acquisition and virulence, including in lung and burn wound infections () and in blood and heart infections (). Here, we present a kinetic and structural characterization of these three opine dehydrogenases. Read More

    [Advances in the research of relationship between brown or beige fat and hypermetabolism after severe burn].
    Zhonghua Shao Shang Za Zhi 2018 Mar;34(3):178-182
    Department of Burns and Plastic Surgery, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.
    Hypermetabolism is one of the remarkable characteristics of burn injury. Prolonged hypermetabolism causes insufficient energy supply, which leads to delayed wound healing, immune system dysfunction, increased infection rate, and multi-organ failure. In recent years, it is concerned that the activation of brown or beige adipose tissue may be related to hypermetabolism in severe burn patients. Read More

    Original and modified technique of tie-over dressing: Method and application in burn patients.
    Burns 2018 Mar 27. Epub 2018 Mar 27.
    Department of Burn Care, Saint-louis Hospital, 1, Avenue Claude Vellefaux, 75010 Paris, France.
    In burn patients, meshed split thickness skin grafts are commonly used on large and non-flat areas whom immobilization is difficult to achieve. The frequent mobilizations of burn patients can make the graft slip and prevent the revascularization and therefore the taking of the skin graft. In order to prevent this pitfall, we modified and adapted the tie-over dressing procedure. Read More

    Draft Genome Sequence of an NDM-1- and KPC-2-Coproducing Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Strain Isolated from Burn Wound Infections.
    Genome Announc 2018 Mar 29;6(13). Epub 2018 Mar 29.
    Department of Bacteriology, First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, People's Republic of China
    We report here the draft genome sequence of an NDM-1- and KPC-2-coproducing hypervirulent carbapenem-resistant strain, isolated from a 58-year-old male in the People's Republic of China with a burn injury. Read More

    The Role of Serotonin during Skin Healing in Post-Thermal Injury.
    Int J Mol Sci 2018 Mar 29;19(4). Epub 2018 Mar 29.
    Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A8, Canada.
    Post-burn trauma significantly raises tissue serotonin concentration at the initial stages of injury, which leads us to investigate its possible role in post burn wound healing. Therefore, we planned this study to examine the role of serotonin in wound healing through in vitro and in vivo models of burn injuries. Results from in vitro analysis revealed that serotonin decreased apoptosis and increased cell survival significantly in human fibroblasts and neonatal keratinocytes. Read More

    Treatment of partial thickness hand burn injuries in children with combination of silver foam dressing and zinc-hyaluronic gel: Case reports.
    Medicine (Baltimore) 2018 Mar;97(13):e9991
    Department of Paediatrics, Surgical Division.
    Rationale: Burns is a common type of traumatic injury in childhood. Nowadays, several wound dressings are available to treat the second-degree hand burns conservatively.

    Patient Concerns, Diagnoses: At the authors' institute, 37 children were treated conservatively with a special dressing at first intervention containing Aquacel Ag foam and Zn-hyaluronic gel to determine their effectiveness on partial thickness hand burns. Read More

    Comamonas kerstersii bacteremia in a patient with acute perforated appendicitis: A rare case report.
    Medicine (Baltimore) 2018 Mar;97(13):e9296
    Department of Burns and Wound Repair Surgery.
    Rationale: Comamonas species are rarely associated with human infections. Recent reports found that Comamonas kerstersii was associated with severe diseases such as abdominal infection and bacteremia. However, C. Read More

    Burn aggravated infected wart in a patient with type 2 diabetes: a medical challenge.
    BMJ Case Rep 2018 Mar 28;2018. Epub 2018 Mar 28.
    Department of Pharmaceutics, Hamdard University, Karachi, Pakistan.
    An infectious wart of foot in a patient with diabetics is a medical challenge, and it gets worse when aggravated with burns. We present a case of a 67-year-old Pakistani man, diabetic for 20 years presented at our healthcare centre. While awaiting his culture sensitivity report, he was prescribed an empiric antibiotic therapy. Read More

    Clinical characteristics of infectious ulceration over tophi in patients with gout.
    J Int Med Res 2018 Jan 1:300060518761303. Epub 2018 Jan 1.
    3 Department of Orthopedics, Wenzhou Central Hospital, Wenzhou 325000, China.
    Objective The aim of this study was to investigate the clinical characteristics of infectious ulceration over tophi in patients with gout. Methods Participants were recruited from the First Affiliated Hospital of Wenzhou Medical University. The clinical characteristics of the patients and wound characteristics were recorded. Read More

    Optimizing mass casualty burns intensive care organization and treatment using evidence-based outcome predictors.
    Burns 2018 Mar 18. Epub 2018 Mar 18.
    Department of Nephrology, Kidney Research Center, Linkou Chang Gung Memorial Hospital, Chang Gung University, College of Medicine, Taoyuan, Taiwan. Electronic address:
    Background: Majority of current research focuses on pre-hospital care in mass casualty incidents (MCI) whereas this study is the first to examine multifactorial aspects of intensive care unit (ICU) resource management during a surge in massive burn injury (MBI) patients whilst identifying key outcome predictors that resulted in successful disaster managements.

    Methods: Both critical care, surgical parameters and cost-effectiveness are investigated in patients admitted with severe burns resulting from the explosion. A fully integrated trauma response and expansion of critical care resources in Linkou Chang Gung Memorial Hospital (CGMH) in this incident is analyzed. Read More

    Expert Outpatient Burn Care in the Home through Mobile Health Technology.
    J Burn Care Res 2018 Mar 17. Epub 2018 Mar 17.
    Division of Pediatric Surgery, Department of Surgery, Medical University of South Carolina, Charleston, South Carolina.
    Access to care for pediatric burns remains a major public health problem in the US. Telemedicine has an opportunity to improve access to care, but current models are expensive and inefficient. We have developed and pilot-tested the TeleBurn App, a novel smartphone application, to treat partial thickness burns while outpatient. Read More

    Evaluation of Glandular Liposculpture as a Single Treatment for Grades I and II Gynaecomastia.
    Aesthetic Plast Surg 2018 Mar 16. Epub 2018 Mar 16.
    Department of Hand and Plastic Surgery, Burn Centre, Linköping University Hospital, 58185, Linköping, Sweden.
    Background: Gynaecomastia is a benign enlargement of the male breast, of which the psychological burden on the patient can be considerable, with the increased risk of disorders such as depression, anxiety, and social phobia. Minimal scarring can be achieved by liposuction alone, though it is known to have a limited effect on the dense glandular and fibroconnective tissues. We know of few studies published on "liposuction alone", so we designed this study to evaluate the outcome of combining liposuction with glandular liposculpturing through two axillary incisions as a single treatment for the management of grades I and II gynaecomastia. Read More

    An efficient antimicrobial depot for infectious site-targeted chemo-photothermal therapy.
    J Nanobiotechnology 2018 Mar 16;16(1):23. Epub 2018 Mar 16.
    Institute of Burn Research, Southwest Hospital, State Key Lab of Trauma, Burn and Combined Injury, Third Military Medical University (Army Medical University), Chongqing, 400038, China.
    Background: Silver and photothermal therapy (PTT) have been widely used for eradicating the drug-resistant bacteria. However, the risks of excess of silver for humans and the low efficiency of PTT still limit their in vivo therapeutic application. Integration of two distinctive bactericides into one entity is a promising platform to improve the efficiency of antimicrobial agents. Read More

    Transcriptome Analysis of Cultured in Human Burn Wound Exudates.
    Front Cell Infect Microbiol 2018 27;8:39. Epub 2018 Feb 27.
    Microbiology Unit, Department of Botany and Plant Biology, Sciences III, University of Geneva, Geneva, Switzerland.
    is a severe opportunistic pathogen and is one of the major causes of hard to treat burn wound infections. Herein we have used an RNA-seq transcriptomic approach to study the behavior of PAO1 growing directly on human burn wound exudate. A chemical analysis of compounds used by this bacterium, coupled with kinetics expression of central genes has allowed us to obtain a global view of physiological and metabolic changes occurring while growing on human burn wound exudate. Read More

    [Chinese expert consensus on tetanus immunization].
    • Authors:
    • ,
    Zhonghua Wai Ke Za Zhi 2018 Mar;56(3):161-167
    Tetanus is an acute specific infection caused by obligate anaerobes, which is still a serious public health problem. Tetanus bacterium is an obligate anaerobic bacterium, widely distributed in nature, which can exist in dust, soil, human or animal excrement. The bacteria invade the body primarily through the skin or mucosal wounds, and most commonly in trauma and burn patients, unclean newborns, and unsafe surgical instruments. Read More

    Immunoproteasome in the Plasma of Paediatric Patients with Moderate and Major Burns, and its Correlation with Proteasome and UCHL1 Measured by SPR Imaging Biosensors.
    J Burn Care Res 2018 Mar 9. Epub 2018 Mar 9.
    Paediatric Surgery Department Medical University of Bialystok, Poland.
    The Aim: to determinate the immunoproteasome concentration in blood plasma of paediatric patients with moderate and major burns, and its correlation with circulating proteasome and UCHL1 with SPRI biosensor.

    Material And Methods: The study population comprised 30 patients with moderate (n=21), and severe burns (n=9), aged 9 months to 14 years. The control group represented 18 healthy, age matched patients, admitted for herniotomy. Read More

    Biogenic synthesis of copper nanoparticles by natural polysaccharides and Pleurotus ostreatus fermented fenugreek using gamma rays with antioxidant and antimicrobial potential towards some wound pathogens.
    Microb Pathog 2018 Mar 9;118:159-169. Epub 2018 Mar 9.
    Drug Radiation Research Department, National Center for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt. Electronic address:
    Mono-dispersed copper nanoparticles (CuNPs) were constructed using cheap polysaccharides (citrus pectin, chitosan, and sodium alginate), and by appropriating aqueous fermented fenugreek powder (FFP) under the action of Pleurotus ostreatus (as reducing and preserving means), through the influence of gamma irradiation. The synthesized CuNPs are described by UV-Vis. spectroscopy TEM, DLS, XRD, and FT-IR. Read More

    Cationic-bilayered nanoemulsion of fusidic acid: an investigation on eradication of methicillin-resistant Staphylococcus aureus 33591 infection in burn wound.
    Nanomedicine (Lond) 2018 Mar 12. Epub 2018 Mar 12.
    University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Studies, Panjab University, Chandigarh, 160014, India.
    Aim: The aim of the current study was to investigate the therapeutic efficacy of cationic-charged bilayered nanoemulsion for topical delivery of fusidic acid in eradicating methicillin-resistant Staphylococcus aureus (MRSA) bacterial burn wound infection.

    Materials & Methods: The developed carriers were characterized for particle size, antibacterial activity, cell viability assay in HaCat cell lines, rheological profile, ex vivo and in vivo studies, namely, full thickness MRSA 33591 murine burn wound infection via topical route.

    Results: The developed cationic bilayered nanogel offered enhanced drug permeation, reduction in bacterial load and enhanced wound contraction along with faster re-epithelialization in burn wounds. Read More

    Cost-effectiveness Analysis of Silver Delivery Approaches in the Management of Partial-thickness Burns.
    Wounds 2018 Feb 23. Epub 2018 Feb 23.
    Department of Plastic Surgery, Kuopio University Hospital, Kuopio, Finland.
    Introduction: Burn injury is a common type of traumatic injury that causes considerable morbidity and mortality, resulting in about 30,000 admissions annually in specialist burn centers and costing around $1 billion per year in the United States. One percent silver sulfadiazine has been utilized widely in the management of burns and newer silver dressings are on the market, including nanocrystalline silver dressings, silver-impregnated hydrofiber dressings, and silver-impregnated foam dressings.

    Objective: This study sought to determine the cost effectiveness of the newer silver dressings using clinical data from an indirect treatment comparison using silver sulfadiazine as the baseline. Read More

    Computerized planimetry evaluation of hyperbaric oxygen therapy in the treatment of diabetic foot.
    Adv Clin Exp Med 2018 Jan;27(1):39-44
    Centre for Burns Treatment, Siemianowice Śląskie, Poland.
    Background: Diabetic foot ulcer is one of the major complications of diabetes mellitus in adults.

    Objectives: The aim of the study was to conduct a planimetry evaluation of the effectiveness of hyperbaric oxygen therapy (HBOT) in the treatment of patients with vascular disorders caused by diabetic foot.

    Material And Methods: The study included 94 patients, 30 females (32%) and 64 males (68%), aged 33-76 years, with diabetes lasting 1. Read More

    Acute burns management: placement reflections of a children's nursing student.
    Nurs Child Young People 2018 Mar;30(2):21-24
    Children and young people's nursing, Faculty of Health and Social Sciences, Bournemouth University, Dorset, England.
    Reflection can help nurses make sense of their clinical surroundings and understand risks, challenges and opportunities. Learning the art required for reflective practice begins as a student when critical reflection is particularly important during practice placements. A suitable reflective framework is provided by Rolfe et al ( 2011 ). Read More

    Using negative pressure wound therapy to prevent surgical site infection.
    J Wound Care 2018 Mar;27(Sup3):S5-S13
    Vice Chairman, Department of Surgery, Chief of Vascular and Endovascular Surgery, Mount Sinai St Luke's and West Hospitals, Professor of Surgery, Icahn School of Medicine, USA.
    It is estimated that, at the very least, 5% of patients who undergo surgery develop a surgical site infection (SSI). There has been much interest in the use of negative pressure wound therapy (NPWT) as a prophylactic treatment to reduce the risk of SSI. Evidence suggests it can accelerate healing times, reduce both the length of hospital stay and the frequency of dressing changes, and improve patients' quality of life. Read More

    Phenylboronic Acid Functionalized Polycarbonate Hydrogels for Controlled Release of Polymyxin B in Pseudomonas Aeruginosa Infected Burn Wounds.
    Adv Healthc Mater 2018 Mar 6. Epub 2018 Mar 6.
    Department of Pharmacy National University of Singapore, 18 Science Drive 4, 117543, Singapore.
    While physically crosslinked polycarbonate hydrogels are effective drug delivery platforms, their hydrophobic nature and lack of side chain functionality or affinity ligands for controlled release of hydrophilic drugs underscore the importance of their chemical compositions. This study evaluates an array of anionic hydrogel systems of phenylboronic acid functionalized triblock copolymers prepared via reversible physical interactions. Variation of key chemical functionalities while maintaining similar core structural features demonstrates the influence of the substitution position and protection of the boronic acid functionality on gel viscoelasticity and mechanical strength at physiological pH. Read More

    Decellularized amnion scaffold with activated PRP: a new paradigm dressing material for burn wound healing.
    Cell Tissue Bank 2018 Mar 5. Epub 2018 Mar 5.
    Department of Stem Cells and Regenerative Medicine, D.Y.Patil University, D. Y. Patil Vidyanagar, Kasba Bawda, Kolhapur, MS, 416006, India.
    Direct application of amnion has greater risk of immunological rejection and infection. Decellularization is an effective method to lower the risk of immune complications and infections. The bioreactor assembly with multiple cassettes was designed for decellurization of multiple amnions with different cell types simultaneously in single run. Read More

    Topical Nystatin Treatment for Candida Infection Following Wound Reconstruction.
    Wounds 2018 Feb;30(2):41-44
    Department of Plastic & Reconstructive Surgery, Shaare Zedek Medical Center, Jerusalem, Israel.
    Introduction: Wound infection is an important cause of nonhealing wounds and graft rejection.

    Objective: A series of 5 patients (4 females, 1 male; median age, 50; age range, 1.5-83 years) with nosocomial Candida infection of burns and chronic wounds that were reconstructed with split-thickness skin grafts is presented. Read More

    Comprehensive Review and Case Study on the Management of Buried Penis Syndrome and Related Panniculectomy.
    Eplasty 2018 1;18:e5. Epub 2018 Feb 1.
    Division of Plastic and Reconstructive Surgery, Hiram C. Polk Jr. M.D. Department of Surgery, University of Louisville School of Medicine, Louisville, Ky.
    This paper discusses the various surgical techniques and outcomes associated with management of buried penis syndrome. Presented is the case of a 49-year-old man with morbid obesity, leading to massive panniculus and buried penis. We review our technique for reconstruction of the buried penis and treatment of the overlying large panniculus. Read More

    Clove Bud Oil Modulates Pathogenicity Phenotypes of the Opportunistic Human Pathogen Pseudomonas aeruginosa.
    Sci Rep 2018 Feb 21;8(1):3437. Epub 2018 Feb 21.
    School of Biotechnology, Amrita University, Amrita Vishwa Vidyapeetham, Clappana P.O., Kollam, Kerala, 690525, India.
    Earlier studies from our laboratory have demonstrated that clove bud oil (CBO) attenuates expression of certain virulence factors of Pseudomonas aeruginosa PAO1. Here, we probe more deeply into the effect of CBO on four pseudomonal proteases - elastase A, elastase B, protease IV and alkaline protease - each known to play key roles in disease pathogenesis. CBO inhibited the activity of these proteases present in the bacterial culture supernatant. Read More

    Methylation of secreted frizzled-related protein 1 (SFRP1) promoter downregulates Wnt/β-catenin activity in keloids.
    J Mol Histol 2018 Apr 17;49(2):185-193. Epub 2018 Feb 17.
    Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Changle Street 15#, Xi'an, Shaanxi, People's Republic of China.
    Keloid, a benign skin disorder, forms during wound healing in genetically susceptible individuals. To better control keloid and understand the molecular mechanisms, this study screened gene hypermethylations of GEO database microarray data on keloids and identified the hypermethylation of the secreted frizzled related protein-1 (SFRP1) promoter. Subsequently, hypermethylation and mRNA and protein levels were assessed in 57 cases of keloid vs. Read More

    Burr hole surgery for chronic subdural hematoma with extensive scalp burn: a case report.
    World Neurosurg 2018 Feb 13. Epub 2018 Feb 13.
    Background: Neurosurgical intervention for a patient with an extensive scalp burn is rare, but it might be associated with the high risk of surgical site infection.

    Case Description: An 80-year-old man had a severe and extensive scalp burn. A chronic subdural hematoma (CSDH) was observed on a head CT for the assessment of bacteremia during treatment in the intensive care unit. Read More

    Efficacy of systemically administered polymyxins in mouse burn wound infection caused by multidrug-resistant Gram-negative pathogens: A proof-of-concept study.
    Antimicrob Agents Chemother 2018 Feb 12. Epub 2018 Feb 12.
    Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia.
    The efficacy of subcutaneously administered polymyxins against burn wound infections caused by , , and was examined in a murine infection model. Subcutaneously administered colistin and polymyxin B achieved a >2-log reduction in the bacterial load for and infections, while wound infections by were less responsive (<1-log reduction). This study highlights the potential therapeutic benefits of parenteral polymyxins for treating burn wound infections. Read More

    Bio-inspired redox-cycling antimicrobial film for sustained generation of reactive oxygen species.
    Biomaterials 2018 Apr 2;162:109-122. Epub 2018 Jan 2.
    Key Laboratory for Ultrafine Materials of Ministry of Education, The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China. Electronic address:
    Open wounds and burns are prone to infection and there remains considerable interest in developing safe and effective mechanisms to confer antimicrobial activities to wound dressings. We report a biomimetic wound dressing for the in situ and sustained generation of reactive oxygen species (ROS). Specifically, we fabricate a catechol-modified chitosan film that mimics features of the melanin capsule generated during an insect immune response to infection. Read More

    Real-time polymerase chain reaction detection of Lichtheimia species in bandages associated with cutaneous mucormycosis in burn patients.
    J Hosp Infect 2018 May 9;99(1):68-74. Epub 2018 Feb 9.
    CHU Lille, Pôle d'Anesthésie-Réanimation, Centre de Traitement des Brûlés, F-59000 Lille, France.
    Background: Cutaneous mucormycoses, mainly due to Lichtheimia (Absidia), have occurred on several occasions in the Burn Unit of the University Hospital of Lille, France.

    Aim: To investigate the potential vector role of non-sterile bandages used to hold in place sterile gauze used for wound dressing.

    Methods: Mycological analysis by conventional culture, Mucorales real-time polymerase chain reaction (qPCR), and Lichtheimia species-specific qPCR were performed on eight crepe and six elasticized bandages that were sampled on two independent occasions in March 2014 and July 2016. Read More

    Effect of retension sutures on abdominal pressure after abdominal surgery.
    Chin J Traumatol 2018 Feb 31;21(1):20-26. Epub 2018 Jan 31.
    Trauma Center, State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China. Electronic address:
    Purpose: To evaluate the effect of retention sutures on abdominal pressure and postoperative prognosis in abdominal surgery patients.

    Methods: This prospective cohort study included patients who were admitted to Daping Hospital from May 15, 2014 to October 11, 2014. A total of 57 patients were enrolled, including 18 patients in the "U" type retention suture group, 17 patients in the intermittent retention suture group, and 22 patients in non-retention suture group. Read More

    Bacteria-responsive intelligent wound dressing: Simultaneous In situ detection and inhibition of bacterial infection for accelerated wound healing.
    Biomaterials 2018 Apr 18;161:11-23. Epub 2018 Jan 18.
    Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China; Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing, 102402, China; Beijing Key Laboratory of Rehabilitation Technical Aids for Old-Age Disability, National Research Center for Rehabilitation Technical Aids, Beijing, 100176, China. Electronic address:
    The evolved resistance of antibiotics exhibited by some dreaded clinical pathogens and formation of biofilms has caused life-threatening problems for patients with burns and other wounds. Here, in order to avoid antibiotic overuse, and thus decreasing the occurrence of antimicrobial-resistant bacteria, a theranostic wound dressing, composed of biocompatible UV-photocrosslinkable methacrylated gelatin (GelMA) encapsulating both antimicrobial and fluorescent vesicles, has been developed. The system can respond to the microbiological environment of the wound via a simple color change and antimicrobials release only when require and this is in essence passive as they do not respond to their local environments and benign bacteria, and only operates when pathogenic bacteria exist. Read More

    Antibacterial Resistance, Biofilm Forming Ability, and Virulence Potential of Pseudomonas aeruginosa Isolated from Burn Patients in Northern of Iran.
    J Glob Antimicrob Resist 2018 Feb 5. Epub 2018 Feb 5.
    Department of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran. Electronic address:
    Objectives: Pseudomonas aeruginosa is frequent in infectious diseases, such as burn and wound infections, making it one of the most promising opportunistic pathogens. The aim of this study was to investigate the antibiotic resistance, biofilm production capacity, and the frequency of genes, which are effective in the biofilm formation and virulence of Pseudomonas aeruginosa, from burn infections.

    Methods: In this study, resistance of 90 P. Read More

    Drug resistance profile and molecular characterization of extended spectrum beta-lactamase (ESβL)-producing Pseudomonas aeruginosa isolated from burn wound infections. Essential oils and their potential for utilization.
    Microb Pathog 2018 Mar 3;116:301-312. Epub 2018 Feb 3.
    Abbasia Chest Hospital, Ministry of Health, 11765 Cairo, Egypt.
    Objectives: Pseudomonas aeruginosa producing extended spectrum β-lactamase (ESβL) enzyme had the ability for antimicrobial resistance mechanisms and its multidrug-resistant (MDR) phenotype, has been increasingly reported as a major clinical concern worldwide. The aim of this study was to (i) characterize ESβL-producing MDR P. aeruginosa isolated from burn wound infections phenotypically and molecularly, (ii) evaluate the antibacterial activity of some essential oils (EOs) against selected ESβL-producing drug resistant P. Read More

    High-voltage electric stimulation of the donor site of skin grafts accelerates the healing process. A randomized blinded clinical trial.
    Burns 2018 May;44(3):636-645
    Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, São Paulo University, Ribeirão Preto, SP, Brazil; Department of Biomechanics, Medicine and Rehabilitation of the Locomotor System, Ribeirão Preto Medical School, São Paulo University, Ribeirão Preto, SP, Brazil. Electronic address:
    Introduction: Severe burns benefit from skin grafting, and grafting surgery is of great importance in the treatment of these injuries. As a result, there is formation of an additional wound at the donor site, which is painful and susceptible to infection. However, the therapeutic approach to these problems at donor sites for skin grafting is insufficiently explored in the literature. Read More

    Extended Islanded Reverse Sural Artery flap for Staged Reconstruction of Foot Defects Proximal to Toes.
    J Coll Physicians Surg Pak 2018 Feb;28(2):126-128
    Department of Plastic Surgery, Jinnah Burn and Reconstructive Surgery Center, Allama Iqbal Medical College, Lahore.
    Obective:To assess the outcome of extended delayed reverse sural artery flap for reconstruction of foot defects proximal to toes in terms of flap survival, complication and extended area.

    Study Design: Case series.

    Place And Duration Of Study: Jinnah Burn and Reconstructive Surgery Centre, Lahore, from February 2015 to April 2017. Read More

    Enhancement of wound healing efficiency mediated by artificial dermis functionalized with EGF or NRG1.
    Biomed Mater 2018 Apr 17;13(4):045007. Epub 2018 Apr 17.
    Burn Institute, Hangang Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Republic of Korea.
    The use of artificial dermis as a skin substitute is a field of active study, as acellular dermal matrices from cadavers are susceptible to infection owing to their human origin. One such alternative dermal replacement scaffold, INSUREGRAF, is derived primarily from extracellular matrix proteins such as collagen and elastin and has been clinically used to treat severe skin wounds such as burns. This scaffold has proven to be useful to minimize wound contraction and scar formation owing to its biocompatibility, interconnected pore structure, sufficient biodegradability, and suitable mechanical properties. Read More

    [Advances in the research of zinc deficiency and zinc supplementation treatment in patients with severe burns].
    Zhonghua Shao Shang Za Zhi 2018 Jan;34(1):57-59
    The First Central Clinical College, Tianjin Medical University, Tianjin 300070, China.
    Zinc is one of the essential trace elements in human body, which plays an important role in regulating acute inflammatory response, glucose metabolism, anti-oxidation, immune and gastrointestinal function of patients with severe burns. Patients with severe burns may suffer from zinc deficiency because of insufficient amount of zinc intake from the diet and a large amount of zinc lose through wounds and urine. Zinc deficiency may affect their wound healing process and prognosis. Read More

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