5,260 results match your criteria Burn Wound Infections


Tornadic Shear Stress Induces a Transient, Calcineurin-Dependent Hypervirulent Phenotype in Mucorales Molds.

mBio 2020 Jun 30;11(3). Epub 2020 Jun 30.

Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA

Trauma-related necrotizing myocutaneous mucormycosis (NMM) has a high morbidity and mortality in victims of combat-related injuries, geometeorological disasters, and severe burns. Inspired by the observation that several recent clusters of NMM have been associated with extreme mechanical forces (e.g. Read More

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http://dx.doi.org/10.1128/mBio.01414-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327176PMC

Epidemiology of burn-related infections in the largest burn unit in Saudi Arabia.

Saudi Med J 2020 Jul;41(7):726-732

Department of Plastic Surgery, Burns Unit, Al-Noor Specialist Hospital, Makkah, Kingdom of Saudi Arabia. E-mail.

Objectives: To first describe the epidemiological data of burns, including burn types and burn-related infections, in adult and pediatric patients. Second, to determine the effect of Methicillin-Resistant Staphylococcus aureus (MRSA) on length of hospital stay and, third, to determine if the microbiological profile differs in patients with severe and non-severe burns. Methods: This is a retrospective chart review in which medical records of all burn patients admitted to Al-Noor Specialist Hospital, Makkah, Kingdom of Saudi Arabia between January 2016 and January 2017 were reviewed for demographic, microbiological, and burn data using a data-collection sheet. Read More

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http://dx.doi.org/10.15537/smj.2020.7.25141DOI Listing

Targeting Tunable Physical Properties of Materials for Chronic Wound Care.

Front Bioeng Biotechnol 2020 11;8:584. Epub 2020 Jun 11.

Department of Burn and Plastic Surgery, Second People's Hospital of Shenzhen, Shenzhen University, Shenzhen, China.

Chronic wounds caused by infections, diabetes, and radiation exposures are becoming a worldwide growing medical burden. Recent progress highlighted the physical signals determining stem cell fates and bacterial resistance, which holds potential to achieve a better wound regeneration . Nanoparticles (NPs) would benefit chronic wound healing. Read More

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http://dx.doi.org/10.3389/fbioe.2020.00584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300298PMC

[One case of severely scalded patient with pneumonia and sepsis].

Zhonghua Shao Shang Za Zhi 2020 Jun;36(6):503-505

Pharmacological Research, Qingdao Municipal Hospital, Qingdao 266011, China.

In February 2018, one 54-year-old male patient with severe scald complicated with pneumonia and sepsis was transferred to Qingdao Municipal Hospital from other hospital. Drugs including cephalosporin, vancomycin, and imipenem/cilastatin combined with ciprofloxacin were used successively for anti-infective treatment, with no obvious effect. Multiple bacterial culture results of sputum, blood, and wound exudate showed infection of extensively drug resistant . Read More

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http://dx.doi.org/10.3760/cma.j.cn501120-20190221-00034DOI Listing

[Clinical application of self-made drainage tubes in different layers of soft tissue for negative-pressure wound therapy in 33 patients].

Zhonghua Shao Shang Za Zhi 2020 Jun;36(6):493-496

Department of Burns and Plastic Surgery, the Affiliated Jiangyin Hospital, Medical College of Southeast University, Jiangyin 214400, China.

From January 2014 to June 2018, 28 patients with different types of deep soft tissue injury or infection were admitted to the Affiliated Jiangyin Hospital of Medical College of Southeast University; 5 patients were admitted to the Zhengzhou First People's Hospital. There were 24 males and 9 females, aged 18-89 (40±20) years. Disposable suction tubes with holes cut on side walls were used as self-made drainage tubes. Read More

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http://dx.doi.org/10.3760/cma.j.cn501120-20190327-00142DOI Listing

[Clinical strategies for preservation of the exposed implant in chronic wounds and wound repair].

Zhonghua Shao Shang Za Zhi 2020 Jun;36(6):484-487

Department of Burns and Plastic Surgery, the Fourth Medical Center of PLA General Hospital, Beijing 100048, China.

To explore the clinical strategies for preservation of the exposed implant in chronic wounds and wound repair. From January 2016 to January 2019, totally 8 patients (4 males and 4 females, aged 10 to 73 years) sustaining postoperative chronic wounds with exposed implants were admitted to the Fourth Medical Center of PLA General Hospital. There were 2 cases of abdominal patch exposure after abdominal trauma surgery, 2 cases of titanium plate exposure post craniocerebral surgery, 3 cases of internal fixator exposure post orthopedic surgery, and 1 case of cerebrospinal fluid drainage tube exposure after craniocerebral surgery. Read More

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http://dx.doi.org/10.3760/cma.j.cn501120-20190215-00027DOI Listing

[Clinical effect of X-N advancement flap in repairing pressure ulcer on the buttock or back].

Zhonghua Shao Shang Za Zhi 2020 Jun;36(6):476-479

Department of Pathology, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou 545005.

To explore the clinical effect of X-N advancement flap in repairing pressure ulcer on the buttock or back. From June 2018 to June 2019, 20 patients with grade Ⅳ pressure ulcers on the buttock or back were hospitalized and treated in the Department of Traumatology, Burns and Plastic Surgery of Fourth Affiliated Hospital of Guangxi Medical University, including 15 males and 5 females, aged 48-89 years. The area of the patient's wound was 8 cm×5 cm-15 cm×12 cm after debridement, and all were repaired with the X-N advancement flap designed by the author. Read More

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http://dx.doi.org/10.3760/cma.j.cn501120-20191011-00399DOI Listing

[Selection and effects of flap/myocutaneous flap repair methods for the defect after perineum tumor resection].

Zhonghua Shao Shang Za Zhi 2020 Jun;36(6):451-457

Department of Gynecologic Oncology, Hunan Cancer Hospital, Changsha 410008, China.

To explore the selection and effects of flap/myocutaneous flap repair methods for the defect after perineum tumor resection. From January 2011 to February 2017, 31 patients with vulvar tumor who were admitted to Hunan Cancer Hospital underwent repair of wound after tumor resection with various flaps/myocutaneous flaps. The patients were composed of 5 males and 26 females, aged 39-76 years, with 27 vulvar cancer and 4 Paget's disease in primary diseases. Read More

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http://dx.doi.org/10.3760/cma.j.cn501120-20190320-00129DOI Listing

[Effects of two dimensional gray-scale blood flow imaging combined with color Doppler flow imaging in guiding arterial puncture and catheterization through wounds in patients with large burns].

Zhonghua Shao Shang Za Zhi 2020 Jun;36(6):440-445

Department of Burn Surgery, the First Hospital of Jilin University, Changchun 130021, China.

To explore the effects of two dimensional gray-scale blood flow imaging (hereinafter referred to as " B-flow" ) combined with color Doppler flow imaging (CDFI) in guiding arterial puncture and catheterization through wounds in patients with large burns. Sixty-seven patients with large burns who met the inclusion criteria and hospitalized in the First Hospital of Jilin University from January 2017 to January 2019 were enrolled in the prospectively randomized control study. According to the random number table, CDFI alone group was allocated with 35 patients (23 males and 12 females) and B-flow+ CDFI group with 32 patients (22 males and 10 females), aged 19-60 and 18-58 years, respectively. Read More

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http://dx.doi.org/10.3760/cma.j.cn501120-20190309-00099DOI Listing

Healthcare-associated infections in burn patients: Timeline and risk factors.

Burns 2020 May 16. Epub 2020 May 16.

Burn Unit, Hospital Universitario del Valle, Universidad del Valle, Cali, Colombia.

Background: Healthcare-associated infections (HAIs) remain a major challenge in burn research and care. We aimed to describe the epidemiology and timeline of HAIs and to estimate the association of demographics and clinical characteristics with time to HAI among burn patients.

Methods: A prospective cohort study was conducted in a referral burn unit in southwestern Colombia. Read More

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http://dx.doi.org/10.1016/j.burns.2020.04.031DOI Listing

Idiopathic necrotizing fasciitis following fracture fixation: A case report.

Medicine (Baltimore) 2020 Jun;99(26):e20874

Department of Orthopaedics, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang Province.

Introduction: Idiopathic necrotizing fasciitis (NF) is an infrequent, highly lethal skin infection that spreads rapidly, marked by fascia and subcutaneous tissue necrosis. It occurs in the absence of a known causative factor. Its emergence after sterile orthopedic fixation with unexpected spread to the abdomen may turn to be challenging both as a medical and surgical emergency. Read More

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http://dx.doi.org/10.1097/MD.0000000000020874DOI Listing
June 2020
5.723 Impact Factor

Epidemiological characteristics and clinical analyses of chronic cutaneous wounds of inpatients in China: Prevention and control.

Wound Repair Regen 2020 Jun 25. Epub 2020 Jun 25.

Department of Burn and Plastic Surgery, The Affiliated Hospital of Jining Medical University, Jining, China.

The increased incidence of chronic cutaneous wounds is likely to lead to increased mortality, and therefore, deserves greater attention. More insight is needed into the magnitude of the problem of chronic cutaneous wounds and methods for their prevention and treatment in China. A retrospective analysis of data retrieved from an electronic health-records database on 3300 patients with chronic skin wounds was conducted from 1 January 2018 to 31 December 2018. Read More

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http://dx.doi.org/10.1111/wrr.12825DOI Listing

Functional Biomaterials for Treatment of Chronic Wound.

Front Bioeng Biotechnol 2020 3;8:516. Epub 2020 Jun 3.

Department of Hand Surgery, The Second Hospital of Jilin University, Changchun, China.

The increasing number of patients with chronic wounds caused by diseases, such as diabetes, malignant tumors, infections, and vasculopathy, has caused severe economic and social burdens. The main clinical treatments for chronic wounds include the systemic use of antibiotics, changing dressings frequently, operative debridement, and flap repair. These routine therapeutic strategies are characterized by a long course of treatment, substantial trauma, and high costs, and fail to produce satisfactory results. Read More

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http://dx.doi.org/10.3389/fbioe.2020.00516DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283526PMC

An Invertebrate Burn Wound Model That Recapitulates the Hallmarks of Burn Trauma and Infection Seen in Mammalian Models.

Front Microbiol 2020 3;11:998. Epub 2020 Jun 3.

Division of Biosciences, Centre for Inflammation Research and Translational Medicine, Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, United Kingdom.

The primary reason for skin graft failure and the mortality of burn wound patients, particularly those in burn intensive care centers, is bacterial infection. Several animal models exist to study burn wound pathogens. The most commonly used model is the mouse, which can be used to study virulence determinants and pathogenicity of a wide range of clinically relevant burn wound pathogens. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283582PMC

The Response of to Hydrogen Sulfide Reveals Two Independent Persulfide-Sensing Systems and a Connection to Biofilm Regulation.

mBio 2020 Jun 23;11(3). Epub 2020 Jun 23.

Department of Chemistry, Indiana University, Bloomington, Indiana, USA

is an opportunistic nosocomial pathogen that is the causative agent of several serious infections in humans, including pneumonia, sepsis, and wound and burn infections. is also capable of forming proteinaceous biofilms on both abiotic and epithelial cell surfaces. Here, we investigate the response of toward sodium sulfide (NaS), known to be associated with some biofilms at oxic/anoxic interfaces. Read More

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http://dx.doi.org/10.1128/mBio.01254-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315123PMC

Negative-pressure wound therapy (NPWT) for the treatment of pacemaker pocket infection in patients unable or unwilling to undergo CIED extraction.

J Interv Card Electrophysiol 2020 Jun 22. Epub 2020 Jun 22.

Department of Burn and Plastic Surgery, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, No. 134, Street East, Fuzhou, 350001, China.

Purpose: The occurrence of cardiac pacemaker pocket infection has markedly increased and has become a new problem facing cardiovascular internists. The aim of our study was to investigate the effectiveness and safety of treating cardiac pacemaker pocket infection using negative-pressure wound therapy (NPWT) in patients who are unwilling or unable to have their cardiac implantable electronic devices (CIEDs) removed.

Methods: From March 2013 to April 2019, NPWT was applied to 26 patients with cardiac pacemaker pocket infection who were unwilling or unable to have their CIEDs removed. Read More

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http://dx.doi.org/10.1007/s10840-020-00805-yDOI Listing

Hand Sanitizers: A Review of Ingredients, Mechanisms of Action, Modes of Delivery, and Efficacy Against Coronaviruses.

Am J Infect Control 2020 Jun 18. Epub 2020 Jun 18.

BC Professional Firefighters' Burn & Wound Healing Research Laboratory, Department of Surgery, Division of Plastic Surgery, iCORD, Vancouver, British Columbia, Canada. Electronic address:

Background: The emergence of the novel virus, SARS-CoV-2, has posed unprecedented challenges to public health around the world. Currently, strategies to deal with COVID-19 are purely supportive and preventative, aimed at reducing transmission. An effective and simple method for reducing transmission of infections in the public or healthcare settings is hand hygiene. Read More

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http://dx.doi.org/10.1016/j.ajic.2020.06.182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301780PMC

A consecutive case series of defects reconstructed using NovoSorb Biodegradable Temporising Matrix: Initial experience and early results.

J Plast Reconstr Aesthet Surg 2020 May 23. Epub 2020 May 23.

Department of Plastic and Reconstructive Surgery and The National Burn Centre, Middlemore Hospital, 100 Hospital Road Otahuhu, Auckland 2025, New Zealand.

Background: NovoSorb Biodegradable Temporising Matrix (BTM) is a synthetic dermal template recently approved for treatment of full thickness defects of the skin. It requires a two-stage reconstruction where it is initially placed into a defect to generate a neodermis, which is later covered by a split skin graft. It has previously been described for the treatment of acute full thickness burn injury, necrotising fasciitis and free flap donor site reconstruction. Read More

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http://dx.doi.org/10.1016/j.bjps.2020.05.067DOI Listing

Patient genetics is linked to chronic wound microbiome composition and healing.

PLoS Pathog 2020 Jun 18;16(6):e1008511. Epub 2020 Jun 18.

Department of Biological Sciences, Texas Tech University, Lubbock, Texas, United States of America.

The clinical importance of microbiomes to the chronicity of wounds is widely appreciated, yet little is understood about patient-specific processes shaping wound microbiome composition. Here, a two-cohort microbiome-genome wide association study is presented through which patient genomic loci associated with chronic wound microbiome diversity were identified. Further investigation revealed that alternative TLN2 and ZNF521 genotypes explained significant inter-patient variation in relative abundance of two key pathogens, Pseudomonas aeruginosa and Staphylococcus epidermidis. Read More

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http://dx.doi.org/10.1371/journal.ppat.1008511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302439PMC

Evaluation of the Efficacy of Ultrapulsed CO Laser in Chronic Wounds.

Lasers Surg Med 2020 Jun 16. Epub 2020 Jun 16.

Department of Plastic and Burn Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, China.

Background And Objectives: Chronic wound repair is a major problem in wound treatment. Recently, several studies have suggested that carbon dioxide (CO ) laser can be used to improve the healing of chronic wounds. The aim of the present study was to preliminarily investigate the efficacy of laser debridement in treating chronic wound through a comparison of traditional instrument/surgical debridement with the ultrapulsed CO laser debridement in terms of wound healing, wound infection control, and wound blood perfusion. Read More

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http://dx.doi.org/10.1002/lsm.23283DOI Listing

Three Year Study of Infection Profile and Antimicrobial Resistance Pattern from Burn Patients in Southwest Iran.

Infect Drug Resist 2020 20;13:1499-1506. Epub 2020 May 20.

Burn Research Center, Surgery Department, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Burn wound infections, as one of the most important risk factors, cause serious complications in burns. Hence, the focus of medical care should be preventing infections and resistant isolates. The current study investigates the prevalence of infectious agents and antimicrobial resistance patterns during three years. Read More

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http://dx.doi.org/10.2147/IDR.S249160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7246306PMC

Efficacy of a Natural Topical Skin Ointment for Managing Split-Thickness Skin Graft Donor Sites: A Pilot Double-blind Randomized Controlled Trial.

Adv Skin Wound Care 2020 Jul;33(7):1-5

At the Tehran University of Medical Sciences, Tehran, Iran, Mohammad Saeed Abbasi, MD, is General Practitioner, Students' Scientific Research Center; Javad Rahmati, MD, is Professor of Plastic Surgery, Department of Plastic Surgery, Razi Hospital; Amir Houshang Ehsani, MD, is Professor of Dermatology, Department of Dermatology, Razi Hospital; Alireza Takzare, MD, is Assistant Professor of Anesthesiology, Children's Medical Center, School of Medicine; Alireza Partoazar, PhD, is Assistant Professor of Pharmacology, Experimental Medicine Research Center; and Nasrin Takzaree, PhD, is Assistant Professor of Histology, Anatomy Department, School of Medicine. The authors have disclosed no financial relationships related to this article. Submitted August 4, 2019; accepted in revised form October 1, 2019.

Objective: To evaluate the safety and efficacy of a new topical skin ointment with natural ingredients (aloe vera, honey, and peppermint) for dressing skin graft donor sites.

Design: A double-blind, placebo-controlled, randomized clinical trial.

Patients And Intervention: Researchers enrolled patients who were referred for split-thickness skin graft after burns or surgical wounds on the scalp or face area. Read More

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http://dx.doi.org/10.1097/01.ASW.0000666916.00983.64DOI Listing

Perforator-Based Flaps for Defect Reconstruction of the Posterior Trunk.

Ann Plast Surg 2020 Jun 11. Epub 2020 Jun 11.

From the Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Ludwigshafen.

Introduction: Full-thickness soft tissue defects of the back remain challenging clinical problems for reconstructive surgeons. Among a vast variety of local flap options, perforator-based local flaps gain increasing popularity lately. Because mostly heterogeneous patient cohort comparison of different perforator flaps is difficult and decision-making algorithms are lacking. Read More

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http://dx.doi.org/10.1097/SAP.0000000000002439DOI Listing

Risk of type III secretion systems in burn patients with Pseudomonas aeruginosa wound infection: A systematic review and meta-analysis.

Burns 2020 May 21. Epub 2020 May 21.

Razi Clinical Research Development Unit, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran. Electronic address:

Purpose: The pathogenesis of Pseudomonas aeruginosa is multifactorial and attributed to the production of several cell-associated and extracellular virulence factors including those implicated in adherence, iron uptake, exoenzymes (Exo) and exotoxins. The present study aimed to determine the prevalence of type III secretion systems (T3SS) effectors in Iranian burn patients with P. aeruginosa wound infection. Read More

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http://dx.doi.org/10.1016/j.burns.2020.04.024DOI Listing
May 2020
1.836 Impact Factor

Gastroepiploic Lymph Node Flap Harvest for Patients With Lymphedema: Minimally Invasive Versus Open Approach.

Ann Plast Surg 2020 Jul;85(S1 Suppl 1):S87-S91

Department of Plastic and Reconstructive Surgery, China Medical University Hospital, Taichung City, Taiwan.

Background: Vascularized gastroepiploic lymph node flaps have become a popular option to treat patients with extremity lymphedema. Overall, 2 surgical approaches to harvest this flap have been described: laparoscopic and open. In this study, we analyzed complications, harvesting time, and patient satisfaction scores, comparing these 2 techniques. Read More

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http://dx.doi.org/10.1097/SAP.0000000000002460DOI Listing
July 2020
1.458 Impact Factor

PDA/Cu Bioactive Hydrogel with "Hot Ions Effect" for Inhibition of Drug-Resistant Bacteria and Enhancement of Infectious Skin Wound Healing.

ACS Appl Mater Interfaces 2020 Jun 29. Epub 2020 Jun 29.

State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, China.

Quick and effective sterilization of drug-resistant bacteria inevitably became an ever-growing global challenge. In this study, a multifunctional composite (PDA/Cu-CS) hydrogel mainly composed of polydopamine (PDA) and copper-doped calcium silicate ceramic (Cu-CS) was prepared. It was confirmed that PDA/copper (PDA/Cu) complexing in the composite hydrogel played a key role in enhancing the photothermal performance and antibacterial activity. Read More

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http://dx.doi.org/10.1021/acsami.0c08890DOI Listing
June 2020
6.723 Impact Factor

Bacterial infection profile and predictors among patients admitted to a burn care center: A retrospective study.

Burns 2020 May 19. Epub 2020 May 19.

Lebanese Geitaoui Hospital, Head of Plastic Surgery Department, Ashrafieh, Geitaoui, Kobayat Street, Bld. 33, Beirut, Lebanon.

Background: Infection is the main cause of mortality and complications in burn patients. The present study was the first to examine the local profile and antecedents of bacterial infections among patients admitted to a Lebanese burn care center.

Methods: The present study was a retrospective analysis of the occurrence and recurrence of infection, its characteristics as well as antimicrobial susceptibility among 475 patients admitted to the Burn Centre at the Lebanese Geitaoui Hospital between January 2014 and December 2018. Read More

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http://dx.doi.org/10.1016/j.burns.2020.05.004DOI Listing

Toxic Epidermal Necrolysis and Steven-Johnson Syndrome: A Comprehensive Review.

Adv Wound Care (New Rochelle) 2020 Jul 9;9(7):426-439. Epub 2020 Jan 9.

Department of Dermatology, Royal North Shore Hospital, Sydney, Australia.

Toxic epidermal necrolysis (TEN) and Steven-Johnson syndrome (SJS) are potentially fatal acute mucocutaneous vesiculobullous disorders. Evidence to date suggests that outcomes for patients with both TEN and SJS are largely dependent on stopping the causative agent, followed by supportive care and appropriate wound management in a specialized burns unit. These are life-threatening conditions characterized by widespread full-thickness cutaneous and mucosal necrosis. Read More

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http://dx.doi.org/10.1089/wound.2019.0977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307670PMC

Characterization of Bacteriological Isolates from Patients and Environment Samples of Burn Ward: A Study from a Tertiary Care Hospital of India.

Infect Disord Drug Targets 2020 Jun 9. Epub 2020 Jun 9.

Department of Microbiology, Government Medical College Hospital, Chandigarh . India.

Objective: Source of infection in a burn patient is from the patient's own flora, contaminated environmental surfaces and from health care workers. Insufficiently disinfected hospital environmental surface provides a niche for multidrug resistant bacteria. This study was done to assess the bacteriological profile of the pathogens from burn wound and the surrounding environmental areas. Read More

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http://dx.doi.org/10.2174/1871526520666200609120659DOI Listing

Glycerol Preserved Amnion: A Viable Source of Biological Dressing for Superficial Partial Thickness Facial Burns.

J Coll Physicians Surg Pak 2020 04;30(4):394-398

Department of Plastic Surgery, Jinnah Burn and Reconstructive Surgery Center, Lahore, Pakistan.

Objectives: To evaluate the role of amnion as a biological dressing in superficial partial thickness facial burns.

Study Design: Randomized controlled trial.

Place And Duration Of Study: Jinnah Burn and Reconstructive Surgery Centre, Lahore, from January 2017 to December 2018. Read More

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http://dx.doi.org/10.29271/jcpsp.2020.04.394DOI Listing

Intermediate Skin Substitutes are unnecessary in small (<10% TBSA) burns.

J Burn Care Res 2020 Jun 2. Epub 2020 Jun 2.

LAC+USC Burn Unit, Los Angeles, California.

Introduction: The use of intermediate skin substitutes between debridement and final autografting is routine for many practitioners. Materials such as xenografts and allografts have been promoted to help with wound coverage before autografting. However there is limited data for their use in relatively small burn wounds (<10% total body surface area, TBSA). Read More

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http://dx.doi.org/10.1093/jbcr/iraa077DOI Listing

Chitosan and phospholipid assisted topical fusidic acid drug delivery in burn wound: Strategies to conquer pharmaceutical and clinical challenges, opportunities and future panorama.

Int J Biol Macromol 2020 May 30;161:325-335. Epub 2020 May 30.

Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India. Electronic address:

Burn is the immense public health issue globally. Low and middle income countries face extensive deaths owing to burn injuries. Availability of conventional therapies for burns has always been painful for patients as well as expensive for our health system. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2020.05.230DOI Listing

Evaluate the effect of zinc oxide and silver nanoparticles (ZnO-Ag NPs) on biofilm and icaA gene expression in methicillin-resistant Staphylococcus aureus (MRSA) isolated from burn wound infection.

J Burn Care Res 2020 Jun 1. Epub 2020 Jun 1.

Assistant Professor, Department of Thoracic Surgery, Qom University of Medical Sciences, Qom, Iran.

Methicillin-resistant Staphylococcus aureus is the cause of nosocomial and community-acquired infections. This study aimed to evaluate the effect of zinc oxide and silver nanoparticles (ZnO-Ag NPs) on biofilms formation and icaA gene expression in methicillin-resistant S. aureus (MRSA). Read More

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http://dx.doi.org/10.1093/jbcr/iraa085DOI Listing

[A pair of baby twins with severe burns simultaneously].

Zhonghua Shao Shang Za Zhi 2020 May;36(5):399-401

Department of Burns, Wound Repair Surgery, People' s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China.

December 22, 2018, a pair of female baby twins aged 2 years with severe burns at the same time were transferred from the primary hospital to the People's Hospital of Xinjiang Uygur Autonomous Region on day 17 post burn. Physical examination on admission showed that both of them had severe burns on head, face, left upper limb, foot, etc. The blood preparations were difficult for them due to their rare blood types, with the elder sister of type B blood combined with Rh D mutant and the younger sister of type B combined with Rh negative blood. Read More

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http://dx.doi.org/10.3760/cma.j.cn501120-20190112-00004DOI Listing

Variable Sculpting in Dynamic Definition Body Contouring: Procedure Selection and Management Algorithm.

Aesthet Surg J 2020 May 26. Epub 2020 May 26.

Background: Nowadays, corporal perception has evolved among different ethnic groups and a tendency to change from a slim to an athletic shape has been influenced by geography, culture, race, gender, and social media. Although exercise improves health status, physical appearance does as well in the long term. Patients often opt for an immediate solution for which High Definition Liposculpture has been the best choice. Read More

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http://dx.doi.org/10.1093/asj/sjaa133DOI Listing

Synergistic antimicrobial activity of melittin with clindamycin on the expression of encoding exfoliative toxin in Staphylococcus aureus.

Toxicon 2020 Aug 22;183:11-19. Epub 2020 May 22.

Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address:

Staphylococcus aureus is an opportunistic human pathogens, with the ability to produce a series of virulence factors that contribute to the severity of infections. Exfoliative toxins (ETs) are one of the important virulence factors that participating in staphylococcal scalded skin syndrome. Melittin has different biological activities, comprising of antiviral, broad spectrum antibacterial, antiprotozoal, antifungal and anti-inflammatory effects. Read More

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http://dx.doi.org/10.1016/j.toxicon.2020.05.004DOI Listing

Antibacterial Fusion Protein BPI21/LL-37 Modification Enhances the Therapeutic Efficacy of hUC-MSCs in Sepsis.

Mol Ther 2020 May 15. Epub 2020 May 15.

Department of Stem Cell and Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042, PR China; Central Laboratory, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University, Chongqing 400042, PR China. Electronic address:

Sepsis, which is characterized by multiple organ dysfunctions as a result of an unbalanced host-inflammatory response to pathogens, is potentially a life-threatening condition and a major cause of death in the intensive care units (ICUs). However, effective treatment or intervention to prevent sepsis-associated lethality is still lacking. Human umbilical cord mesenchymal stem cell (hUC-MSC) transplantation has been shown to have potent immunomodulatory properties and improve tissue repair yet lacks direct antibacterial and endotoxin clearance activities. Read More

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http://dx.doi.org/10.1016/j.ymthe.2020.05.014DOI Listing

Hidden threat lurking behind the alcohol sanitizers in COVID-19 outbreak.

Dermatol Ther 2020 May 20:e13627. Epub 2020 May 20.

Microbiology Department, Burn and Wound Healing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

The ongoing COVID-19 pandemic has made various challenges for communications all over the world. Nowadays hand hygiene practices with alcohol sanitizers are an unavoidable reality for many people, which cause skin dryness and flaking. The current short communication has been explained about monitoring the quality control of alcohol concentrations and hand rub formulation, which needs more attention and should consider meticulous in this crisis. Read More

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http://dx.doi.org/10.1111/dth.13627DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280687PMC
May 2020
1.478 Impact Factor

Reconstruction of sternal defects after sternotomy with postoperative osteomyelitis, using a unilateral pectoralis major advancement muscle flap.

Sci Rep 2020 May 20;10(1):8380. Epub 2020 May 20.

Department of Hand Surgery, Plastic Surgery and Burns, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Background: The pectoralis major flap, which is usually harvested bilaterally, is considered a workhorse flap in the reconstruction of sternal defects. After a median sternotomy for open heart surgery, 1%-3% of patients develop deep infection and dehiscence of the sternal wound, some of which will eventually require reconstructive surgery. Our aim was to describe the clinical feasibility and associated complications of the unilateral pectoralis major advancement flap in the reconstruction of sternal defects. Read More

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http://dx.doi.org/10.1038/s41598-020-65398-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239941PMC

Effectiveness of topical α-Tocopherol Acetate in burn infection treatment.

Ann Burns Fire Disasters 2019 Dec;32(4):282-288

Plastic and Reconstructive Microsurgery, Careggi University Hospital, Florence, Italy.

Infection following burn injury is critical, especially for patients with large total body surface area burns and in skin graft donor sites. Although various aspects of α-tocopherol acetate (α-TA) beneficial effects on wound healing have been validated, it appears that no study has specifically addressed its antimicrobial potential. The purpose of this study was to explore the therapeutic efficacy of topical application of α-TA in terms of bacterial load reduction. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197917PMC
December 2019

Response to "Burn wound infections and Pseudomonas aeruginosa".

Burns 2020 Apr 27. Epub 2020 Apr 27.

Department of Pediatric Plastic surgery, AP-HM, Timone Pediatric University Center, 264, rue Saint-Pierre, 13385 Marseille, France.

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http://dx.doi.org/10.1016/j.burns.2020.02.019DOI Listing

Novel Therapeutics for the Treatment of Burn Infection.

Surg Infect (Larchmt) 2020 May 19. Epub 2020 May 19.

Division of Research, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Burn injury continues to be a significant cause of morbidity and death, with infectious complications being the primary cause of death. Patients are susceptible to overwhelming infection secondary to both the physical breakdown of the skin and mucosal barrier and the immune dysfunction that accompanies the inflammatory response to a major burn. With resistance to traditional antibiosis looming as a serious threat to patient outcome, advancement in the treatment of burn infections is imperative. Read More

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http://dx.doi.org/10.1089/sur.2020.104DOI Listing

Correction to: Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis.

Cell Commun Signal 2020 May 18;18(1):74. Epub 2020 May 18.

State Key Laboratory of Trauma, Burns and Combined Injury, Department of Wound Infection and Drug, Daping Hospital, Army Medical University, Yuzhong District, Chongqing, China.

An amendment to this paper has been published and can be accessed via the original article. Read More

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http://dx.doi.org/10.1186/s12964-020-00597-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236199PMC

The use of hydrogen peroxide in the treatment of burn wound infection: a systematic review, and survey of current clinical practice in the United Kingdom.

Int J Burns Trauma 2020 15;10(2):38-46. Epub 2020 Apr 15.

Department of Vascular Surgery, Morriston Hospital United Kingdom.

Background: Current treatment of burn wound infection (BWI) is with antibiotics and/or wound cleaning/superficial debridement. The overuse of antibiotics has contributed to antibiotic resistance. One possible solution is the use of hydrogen peroxide (HO). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218693PMC

The effect of black and green tea extracts on some bacteria-infected burns skin in rats.

Cell Mol Biol (Noisy-le-grand) 2020 May 15;66(2):78-86. Epub 2020 May 15.

Department of Biology, Salahaddin University-Erbil, Iraq.

Herbal teas are the most common natural alternatives for the treatment of infectious diseases due to increasing antibiotic resistance, and are increasingly gaining more popularity and are known for their activity of antibacterial to many pathogenic micro-organisms. This research was necessitated by the need to counter the rapid emergence of drug-resistant human pathogens, which is becoming a regular phenomenon in the world making life-threatening illnesses easily curable infections. The study was done to determine the antimicrobial activities by agar diffusion inhibition assay of black and green tea Extract (cold and hot) against Pseudomonas aeruginosa and Staphylococcus aureus antibiotic resistance after injuring the skin of rats for burning, also to screen the effect of both types of tea on rat skin healing. Read More

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Optimization of human-like collagen composite polysaccharide hydrogel dressing preparation using response surface for burn repair.

Carbohydr Polym 2020 Jul 6;239:116249. Epub 2020 Apr 6.

Shaanxi Key Laboratory of Degradable Biomedical Materials, School of Chemical Engineering, Northwest University, Taibai North Road 229, Xi'an, 710069, China; Shaanxi R&D Center of Biomaterials and Fermentation Engineering, School of Chemical Engineering, Northwest University, Xi'an, 710069, China; Biotech & Biomed Research Institute, Northwest University, Xi'an, 710069, China. Electronic address:

Collagen and polysaccharide materials have great advantages for burn wound healing and skin regeneration. The purpose of this study was to develop a promising burn dressing. Mixing hyaluronic acid (HA), carboxylated chitosan (CCS) and human-like collagen (HLC) to simulate extracellular matrix (ECM), and glutamine transaminase (TG) was used as a crosslinker. Read More

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http://dx.doi.org/10.1016/j.carbpol.2020.116249DOI Listing

The combination of antimicrobial photocatalysis and antimicrobial photodynamic therapy to eradicate the extensively drug-resistant colistin resistant Acinetobacter baumannii.

Photodiagnosis Photodyn Ther 2020 May 10:101816. Epub 2020 May 10.

Oral Microbiology Laboratory, Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Keshavarz Blvd, 100 Poursina Ave. Tehran, Iran. Electronic address:

Background: The appearance of bacterial resistance to antibiotics and its extensions are major health problems that guidance to treatment losing for a large number of drugs. Antimicrobial photodynamic therapy (aPDT) has emerged as an adjunctive treatment for drug-resistant infections. Titanium dioxide (TiO) and zinc oxide (ZnO) nanoparticles have recently been proposed as effective carriers for photosensitizers. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101816DOI Listing

Burn wound microbiology and the antibiotic susceptibility patterns of bacterial isolates in three burn units of Abbottabad, Pakistan.

J Burn Care Res 2020 May 13. Epub 2020 May 13.

Department of Microbiology, Abbottabad University of Science and Technology, Havelian , Abbottabad, Pakistan.

Infection is the leading cause of morbidity and mortality among burn patients and is accentuated multifold by the emergence of antimicrobial resistance among the nosocomial isolates. It is vital to know the common organisms involved in infected burn wound etiology and their respective antibiotic susceptibility patterns. These crucial findings can help in formulating a better and more efficient antimicrobial therapy plan for controlling burn wound infections. Read More

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http://dx.doi.org/10.1093/jbcr/iraa073DOI Listing

A Rare Case of Fungal Burn Wound Infection Caused by in Vietnam.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620912122

Vietnam Military Medical University, Ha Noi, Vietnam.

A patient with extensive burn injuries was admitted to the National Hospital of Burns in Hanoi, Vietnam, and diagnosed with fungal wound infection by histological examination of skin biopsy samples. was isolated and identified by analysis of its morphological features and the sequence of the internal transcribed spacer region. The isolation showed in vitro resistant to fluconazole, voriconazole, itraconazole, amphotericin B, and caspofungin. Read More

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http://dx.doi.org/10.1177/2324709620912122DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223860PMC

Platelet-rich plasma loaded with antibiotics as an affiliated treatment for infected bone defect by combining wound healing property and antibacterial activity.

Platelets 2020 May 12:1-13. Epub 2020 May 12.

Department of Emergency Medicine of Daping Hospital, Army Medical University, Chongqing, China.

To be faced with an infected bone defect and the need to accelerate bone union while controlling infection is a welcome challenge for orthopedists. Platelet-rich plasma (PRP) has been applied in tissue defects given their composition of growth factors however the weak antibacterial effects have limited the use of PRP in the clinical setting. Therefore, the aim of this study was to explore the feasibility of using PRP in a local antibiotic delivery system (PADS) with the characteristics of promoting wound healing of bone infection. Read More

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http://dx.doi.org/10.1080/09537104.2020.1759792DOI Listing
May 2020
2.627 Impact Factor