5,628 results match your criteria Burn Wound Infections


Antimicrobial Peptide Dendrimers and Quorum-Sensing Inhibitors in Formulating Next-Generation Anti-Infection Cell Therapy Dressings for Burns.

Molecules 2021 Jun 24;26(13). Epub 2021 Jun 24.

Department of Microbiology and Molecular Medicine, University of Geneva, 1211 Geneva, Switzerland.

Multidrug resistance infections are the main cause of failure in the pro-regenerative cell-mediated therapy of burn wounds. The collagen-based matrices for delivery of cells could be potential substrates to support bacterial growth and subsequent lysis of the collagen leading to a cell therapy loss. In this article, we report the development of a new generation of cell therapy formulations with the capacity to resist infections through the bactericidal effect of antimicrobial peptide dendrimers and the anti-virulence effect of anti-quorum sensing MvfR (PqsR) system compounds, which are incorporated into their formulation. Read More

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Nandrolone decanoate safely combats catabolism in burned patients: A new potential indication after recall.

Burns 2021 Apr 21. Epub 2021 Apr 21.

Nile University, Faculty of Biotechnology, 6th of October City, Egypt. Electronic address:

Introduction: The hyper-catabolic state is a devastating pathophysiological response to severe injury, infection or burns. Nandrolone decanoate (ND) is a potent anabolic steroid have many clinical indications, but not investigated in burn injuries yet.

Patients And Methods: A prospective randomized control study included 40 burned patients who were treated in Burn unit from burn injuries ranged from 20 to 40%. Read More

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Hyperbaric oxygen treatment for toxic epidermal necrolysis: A case report.

Diving Hyperb Med 2021 Jun;51(2):216-219

University of Health Sciences, Kartal Dr Lütfi Kirdar City Hospital, Department of Infectious Diseases and Clinical Microbiology, Istanbul, Turkey.

Toxic epidermal necrolysis (TEN) is a potentially life-threatening muco-cutaneous disease, largely caused by an idiosyncratic reaction to medication or infectious disease, and is characterised by acute necrosis of the epidermis. No definitive consensus regarding the treatment of TEN has been agreed. A 60-year-old woman, diagnosed with multiple myeloma three months prior, was admitted with signs of TEN to the intensive care burns unit. Read More

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Study of quorum-sensing and genes and their dependent virulence factors in isolates from infected burn wounds.

Access Microbiol 2021 Mar 5;3(3):000211. Epub 2021 Mar 5.

Medical Microbiology & Immunology Department, Faculty of Medicine, Mansoura University, Egypt.

Background: is an opportunistic pathogen responsible for burn-wound infection. High incidence, infection severity and increasing resistance characterize -induced burn infection.

Purpose: To estimate quorum-sensing (QS)-dependent virulence factors of isolates from burn wounds and correlate it to the presence of QS genes. Read More

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Complex Multidisciplinary Cranial and Scalp Reconstruction for Patient Salvage.

World Neurosurg 2021 Aug 16;152:e549-e557. Epub 2021 Jun 16.

Division of Neurological Surgery, University of Missouri School of Medicine, One Hospital Drive, Columbia, Missouri, USA. Electronic address:

Objective/background: Patients can develop scalp and cranial defects as a result of neoplasm, trauma, or infection. Reconstruction of these defects can be difficult in some patients and may require a multidisciplinary approach using creative solutions usually used for disease processes in other areas of the body, such as severe burns.

Methods: A series of 9 patients were treated using multidisciplinary techniques for reconstruction of complex cranial and scalp defects. Read More

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Outcomes For Hand Burns Treated With Autologous Skin Cell Suspension In 20% Tbsa And Smaller Injuries.

J Burn Care Res 2021 Jun 18. Epub 2021 Jun 18.

University Medical Center-New Orleans Burn Program, LSUHSC-New Orleans of Burn Surgery.

Hypothesis: In order to address the confounder of TBSA on burn outcomes, we sought to analyze our experience with the use of autologous skin cell suspensions (ASCS) in a cohort of subjects with hand burns whose TBSA totaled 20% or less. We hypothesized that the use of ASCS in conjunction with 2:1 meshed autograft for the treatment of hand burn injuries would provide comparable outcomes to hand burns treated with sheet or minimally meshed autograft alone.

Methods: A retrospective review was conducted for all deep partial and full thickness hand burns treated with split thickness autograft (STAG) at our urban verified burn center between April, 2018 to September, 2020. Read More

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[Epidemiological investigation and analysis of etiological characteristics of infection on 3067 hospitalized pediatric patients with burns].

Zhonghua Shao Shang Za Zhi 2021 May 31;37:1-8. Epub 2021 May 31.

State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400038, China.

To investigate the epidemiological characteristics and etiological distribution of infection on 3067 hospitalized pediatric patients with burns, and explore the prevention and treatment strategy of pediatric burns. A cross-sectional survey was conducted. Retrospective analysis was performed on the data of 3067 hospitalized pediatric patients with burns who met the inclusion criteria and admitted to the First Affiliated Hospital of Army Medical University (the Third Military Medical University) from January 2012 to December 2020, including gender, ages, burns types, locations, severities of burns, and seasons of accidents, and type of pathogenic bacteria, source of tissue or body fluid, and drug resistance. Read More

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[Multidrug resistant organisms in burn insensitive care unit: strategies and opinions].

Authors:
Z Q Yuan Y Z Peng

Zhonghua Shao Shang Za Zhi 2021 May 31;37:1-6. Epub 2021 May 31.

State Key Laboratory of Trauma, Burns, and Combined Injury, Institute of Burn Research, the First Affiliated Hospital of Army Medical University (the Third Military Medical University), Chongqing 400038, China.

Infections caused by multidrug-resistant (MDR) organisms can significantly increase the mortality in patients with burn injury. Management and prevention of MDR infections in burn insensitive care unit (ICU) is a problematic challenge in clinical treatment of severe burn patients. Nosocomial infection prevention and control measures play a critical role to minimize the spread of MDR bacteria in burn ICU. Read More

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[National expert consensus on the application of negative pressure wound therapy in the treatment of diabetic foot wounds (2021 version)].

Authors:

Zhonghua Shao Shang Za Zhi 2021 Jun 10;37(6):508-518. Epub 2021 Jun 10.

Diabetic foot has a high rate of disability and mortality. Negative pressure wound therapy (NPWT) is one of the effective techniques in treating diabetic foot wounds, but the non-standard use of it often leads to infections, bleeding, necrosis and other complications, which seriously affects the outcome. In 2020, Tissue Repair of Burns and Trauma Committee, Cross-Straits Medicine Exchange Association organized experts from department of burns, department of orthopedics, department of vascular surgery, department of endocrinology, department of wound repair, and other departments engaged in the treatment of diabetic foot to discuss and write the "". Read More

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Application Of Cling Film Over Burn Wounds (Occlusive Wound Dressing): Our Experience.

J Ayub Med Coll Abbottabad 2021 Apr-Jun;33(2):236-239

Jinnah Burn and Reconstructive Surgery Centre, Lahore, Pakistan.

Background: This study shares our experience and review the outcome of the use of cling film with silver sulfadiazine cream in terms of healing time, and patient's satisfaction score.

Methods: It was a descriptive case series conducted at Jinnah Burn and Reconstructive Surgery Center, Lahore, from March 2018 to February 2019. In this study, a thick layer of silver sulfadiazine was applied and then wrapped with cling film on 35 patients sustained mix thickness burns on the trunk and limbs. Read More

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Gut Microbiota Regulate Gut-Lung Axis Inflammatory Responses by Mediating ILC2 Compartmental Migration.

J Immunol 2021 Jun 16. Epub 2021 Jun 16.

Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND;

Gut microbiota is increasingly linked to the development of various pulmonary diseases through a gut-lung axis. However, the mechanisms by which gut commensal microbes impact trafficking and functional transition of immune cells remain largely unknown. Using integrated microbiota dysbiosis approaches, we uncover that the gut microbiota directs the migration of group 2 innate lymphoid cells (ILC2s) from the gut to the lung through a gut-lung axis. Read More

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Evaluation of Pseudomonas aeruginosa pathogenesis and therapeutics in military-relevant animal infection models.

APMIS 2021 Jun 15. Epub 2021 Jun 15.

Wound Infections Department, Bacterial Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.

Modern combat-related injuries are often associated with acute polytrauma. As a consequence of severe combat-related injuries, a dysregulated immune response results in serious infectious complications. The gram-negative bacterium Pseudomonas aeruginosa is an opportunistic pathogen that often causes life-threatening bloodstream, lung, bone, urinary tract, and wound infections following combat-related injuries. Read More

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Vacuum-Assisted Closure and Skin Grafting Combined with Amphotericin B for Successful Treatment of an Immunocompromised Patient with Cutaneous Mucormycosis Caused by Mucor irregularis: A Case Report and Literature Review.

Mycopathologia 2021 Jun 15;186(3):449-459. Epub 2021 Jun 15.

Department of Dermatology, The First Affiliated Hospital, Sun Yat-Sen University, No. 58, Zhongshan 2nd Road, Guangzhou, 510080, China.

Cutaneous mucormycosis caused by Mucor irregularis (M. irregularis) is a rare condition that typically occurs in immunocompetent patients. Herein, we describe an immunocompromised patient with cutaneous M. Read More

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Anti-flagellin IgY antibodies protect against Pseudomonas aeruginosa infection in both acute pneumonia and burn wound murine models in a non-type-specific mode.

Mol Immunol 2021 Aug 12;136:118-127. Epub 2021 Jun 12.

Medicinal Plants Research Center, Shahed University, Tehran, Iran.

Pseudomonas aeruginosa (PA) is one of the most dominant causes of nosocomial infections in burn patients. Increasing emergence of antibiotic-resistant strains highlights the need for novel antimicrobial agents. Flagellin, the main component protein of flagellum, is determined as the major antigen interacting with anti-P. Read More

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Variation in definitions of burn wound infection limits the validity of systematic review findings in burn care: A systematic review of systematic reviews.

Burns 2021 May 15. Epub 2021 May 15.

Centre for Academic Child Health, University of Bristol, 1-5 Whiteladies Road, Bristol BS8 1NU, United Kingdom. Electronic address:

Introduction: Systematic reviews (SR) of high-quality randomised controlled trials can identify effective treatments for burn wound infections (BWIs). Clinical heterogeneity in outcome definitions can prevent valid evidence synthesis, which may limit the reliability of the findings of SRs affected by this heterogeneity. This SR aimed to investigate whether there is variation BWI definitions across studies in SRs of burn care interventions and its impact on identification of effective treatments for patients with burn injuries. Read More

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Chitosan-based hydrogels to treat hydrofluoric acid burns and prevent infection.

Drug Deliv Transl Res 2021 Aug 14;11(4):1532-1544. Epub 2021 Jun 14.

Department of Emergency Medicine, Taipei Veterans General Hospital, 11217, Taipei, Taiwan.

There is an urgent need for treatments for hydrofluoric acid (HF) burns and their derivative problems that prevent hydrogen ion dissociation and fluoride ion binding to tissues. This study evaluated the ability of chitosan-based hydrogels combined with a buffer solution containing either boric acid or Tris and calcium gluconate (CHS-BA-CG and CHS-Tris-CG) to repair HF burn wounds and prevent wound infections. We assessed calcium release rates and biocompatability and constructed a mouse HF burn model to assess the tissue repair effects of the hydrogels. Read More

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Wildfire Burn Patients: A Unique Population.

J Burn Care Res 2021 Jun 9. Epub 2021 Jun 9.

Department of Surgery, Division of Burn Surgery, University of California, Davis, California.

In the past ten years wildfires have burned an average of 6.8 million acres per year and this is expected to increase with climate change. Wildfire burn patient outcomes have not been previously well characterized. Read More

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Mortality incidence among critically ill burn patients infected with multidrug-resistant organisms: A retrospective cohort study.

Scars Burn Heal 2021 Jan-Dec;7:20595131211015133. Epub 2021 May 25.

Critical Care Departement, Al-Wakra Hospital, Hamad Medical Corporation, Doha, Qatar.

Introduction: Many risk factors have been reported to increase mortality among burn patients. Previously, a higher mortality incidence was reported in acute burn patients infected with multidrug-resistant organisms (MDROs) when compared to patients infected with non-MDROs. However, considering this as an independent risk factor for mortality in acute burn patients is not yet confirmed. Read More

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A retrospective surveillance of the prophylactic antibiotics for debridement surgery in burn patients.

Int J Burns Trauma 2021 15;11(2):96-104. Epub 2021 Apr 15.

Department of Clinical Pharmacy, Study Program of Pharmacy, Hang Tuah University Surabaya, East Java-Indonesia.

Burn injury is trauma with a high risk of infection. A method that can be used to prevent and decrease the incidence of infection and accelerate wound healing is debridement. The use of prophylactic antibiotics was considered in debridement to minimize surgical site infection. Read More

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Safety and donor site morbidity of the transverse musculocutaneous gracilis (TMG) flap in autologous breast reconstruction-A systematic review and meta-analysis.

J Surg Oncol 2021 Jun 6. Epub 2021 Jun 6.

Department of Hand, Plastic and Reconstructive Surgery, Microsurgery, Burn Center, BG Trauma Center Ludwigshafen, Hand and Plastic Surgery, University of Heidelberg, Ludwigshafen, Germany.

Background And Objectives: The transverse musculocutaneous gracilis (TMG) flap has gained popularity for breast reconstruction. However, the literature regarding its donor site morbidity is heterogeneous. This systematic review sought to clarify the evidence on donor site morbidity. Read More

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Prevention of transoral thyroidectomy complications: An analysis of surgical outcomes in 423 consecutive series.

Surgery 2021 Jun 2. Epub 2021 Jun 2.

Department of Otolaryngology-Head and Neck Surgery, The Johns Hopkins University School of Medicine, Baltimore, MD.

Background: Although there are several publications on the new transoral robotic thyroidectomy technique, few have thoroughly reviewed its associated complications. This study analyzed the causes and prevention of transoral robotic thyroidectomy-specific complications and presented preventive measures.

Methods: The medical records of patients who underwent transoral robotic thyroidectomy performed by a single surgeon between March 1, 2009 and April 30, 2019 were retrospectively analyzed. Read More

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Bitter receptor TAS2R138 facilitates lipid droplet degradation in neutrophils during Pseudomonas aeruginosa infection.

Signal Transduct Target Ther 2021 Jun 4;6(1):210. Epub 2021 Jun 4.

Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.

Bitter receptors function primarily in sensing taste, but may also have other functions, such as detecting pathogenic organisms due to their agile response to foreign objects. The mouse taste receptor type-2 member 138 (TAS2R138) is a member of the G-protein-coupled bitter receptor family, which is not only found in the tongue and nasal cavity, but also widely distributed in other organs, such as the respiratory tract, gut, and lungs. Despite its diverse functions, the role of TAS2R138 in host defense against bacterial infection is largely unknown. Read More

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The Mould War: Developing an Armamentarium against Fungal Pathogens Utilising Thymoquinone, Ocimene, and Miramistin within Bacterial Cellulose Matrices.

Materials (Basel) 2021 May 18;14(10). Epub 2021 May 18.

Wolverhampton School of Sciences, Faculty of Science and Engineering, University of Wolverhampton, Wulfruna Street, Wolverhampton WV1 1LY, UK.

An increase in antifungal resistance has seen a surge in fungal wound infections in patients who are immunocompromised resulting from chemotherapy, disease, and burns. Human pathogenic fungi are increasingly becoming resistant to a sparse repertoire of existing antifungal drugs, which has given rise to the need to develop novel treatments for potentially lethal infections. Bacterial cellulose (BC) produced by has been shown to possess many properties that make it innately useful as a next-generation biopolymer to be utilised as a wound dressing. Read More

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Xylitol Inhibits Growth and Blocks Virulence in .

Microorganisms 2021 May 18;9(5). Epub 2021 May 18.

Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.

is an opportunistic nosocomial pathogen and causes wound and burn infections. It shows high resistance to antibiotics and its pathogenicity is mediated by an arsenal of virulence factors. Another therapeutic option to such infections is targeting quorum sensing (QS), which controls the expression of different virulence factors. Read More

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Development of an Experimental Ex Vivo Wound Model to Evaluate Antimicrobial Efficacy of Topical Formulations.

Int J Mol Sci 2021 May 10;22(9). Epub 2021 May 10.

Division of Dermatology and Venereology, Department of Clinical Sciences, Lund University, SE-22184 Lund, Sweden.

Wound infections are considered a major cause for wound-associated morbidity. There is a high demand for alternative, robust, and affordable methods that can provide relatable and reproducible results when testing topical treatments, both in research and in the pharmaceutical industry. Here we present an ex vivo wound infection model using porcine skin and a burn wounding method, allowing for the efficacy evaluation of topical antimicrobial formulations. Read More

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Chitosomes-In-Chitosan Hydrogel for Acute Skin Injuries: Prevention and Infection Control.

Mar Drugs 2021 May 12;19(5). Epub 2021 May 12.

Drug Transport and Delivery Research Group, Department of Pharmacy, University of Tromsø The Arctic University of Norway, Universitetsvegen 57, 9037 Tromsø, Norway.

Burns and other skin injuries are growing concerns as well as challenges in an era of antimicrobial resistance. Novel treatment options to improve the prevention and eradication of infectious skin biofilm-producing pathogens, while enhancing wound healing, are urgently needed for the timely treatment of infection-prone injuries. Treatment of acute skin injuries requires tailoring of formulation to assure both proper skin retention and the appropriate release of incorporated antimicrobials. Read More

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Distribution and antimicrobial susceptibility profile of bacterial and fungal pathogens isolated from burn wounds in hospitalized patients.

J Pak Med Assoc 2021 Mar;71(3):916-920

Department of Veterinary Biomedical Sciences, PMAS Arid Agriculture University Rawalpindi, Pakistan.

Objective: Current study was designed to isolate the pathogens from burn wounds and determine the antibiogram of these isolates.

Methods: A total of 85 samples were collected from burn patients with the history of different weeks of hospitalization in various public and private hospitals of Faisalabad during September 2017-July 2019 and shifted to Department of Microbiology, Government College University, Faisalabad for further processing. Isolation and identification of the pathogens was done through conventional microbiological procedures. Read More

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Non-Healing Burn Wound Treatment With A Sterile Silicone Gel.

Ann Burns Fire Disasters 2021 Mar;34(1):53-57

Burn Centre, Cisanello University Hospital, Pisa, Italy.

Treatment of burn wounds can be complicated due to fluid and electrolyte loss and the increased chance of infectious complications. Silicone-based products have become increasingly used for non-healing wound treatment, but no study has specifically addressed its potential on burn patients. The purpose of this study was to compare the use of sterile silicone gel with conventional medication in improving the healing of burn wounds. Read More

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Does Platelet-Rich Fibrin Enhance Healing Of Burn Wounds? Our First Experiences And Main Pitfalls.

Ann Burns Fire Disasters 2021 Mar;34(1):42-52

Department of Plastic Surgery, Hand Surgery, Burn Center, University of Witten/Herdecke, Cologne-Merheim Medical Center (CMMC), Cologne, Germany.

Recent research found that enzymatic debridement clearly improves long-term scarring in burns. By reducing the spontaneous wound-healing period, scarring might be optimized. The latest publications show that wound healing can be accelerated by the application of platelet-rich fibrin (PRF). Read More

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[Analysis on the diagnosis and treatment of necrotizing fasciitis complicated with sepsis].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Apr;33(4):483-486

Department of Burn and Wound Repair Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangzhou 510080, Guangdong, China. Corresponding author: Lai Wen, Email:

Objective: To recognize the characteristics of necrotizing fasciitis patients complicated with sepsis and summarize the experience the treatment.

Methods: A retrospective study was conducted. The clinical data of 57 patients with necrotizing fasciitis complicated with sepsis admitted to Guangdong Provincial People's Hospital from July 2009 to December 2019 was analyzed by collecting such factors as gender, age, complications, infection sites, pathogens, surgery information, treatment options and outcome. Read More

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