12,360 results match your criteria Burkitt Lymphoma


X-Linked Lymphoproliferative Disease in Latvia: A Report of Two Clinically Distinct Cases.

Case Rep Med 2020 21;2020:7108657. Epub 2020 Jul 21.

Riga Stradins University, Riga, Latvia.

X-linked lymphoproliferative disease (XLP) is a rare primary immunodeficiency. Affected individuals usually present with the Epstein-Barr virus infection and have no apparent disease prior to presentation. The most common clinical manifestations are fulminant infectious mononucleosis, dysgammaglobulinaemia, and lymphoma (usually of B-cell origin). Read More

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http://dx.doi.org/10.1155/2020/7108657DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7396099PMC

Palmar-plantar erythrodysesthesia associated with high-dose methotrexate: Case report.

Cancer Rep (Hoboken) 2020 Aug 7:e1270. Epub 2020 Aug 7.

Department of Hematology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Background: Palmar-plantar erythrodysesthesia (PPE) is a common adverse event seen with many chemotherapeutic agents as well as targeted therapies which is very debilitating for the patient. To the best of our knowledge there are only a few cases of PPE reported with methotrexate infusion to date.

Case And Conclusion: We report a case of Burkitt Lymphoma, who developed severe PPE with methotrexate infusion and responded very well with conservative management and dose reduction in subsequent cycles. Read More

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http://dx.doi.org/10.1002/cnr2.1270DOI Listing

In childhood mature B-NHL with CNS disease, patients with blasts in cerebrospinal fluid are at higher risk of failure.

Blood Adv 2020 Aug;4(15):3621-3625

Department of Pediatric and Adolescent Oncology, Gustave Roussy, Paris-Saclay University, Villejuif, France; and.

To identify the factors influencing outcome in childhood mature B-cell non-Hodgkin lymphoma and acute leukemia (B-NHL/AL) with central nervous system (CNS) disease (CNS+), we analyzed patients <18 years with newly diagnosed B-NHL/AL registered in 3 Lymphomes Malins B studies in France between 1989 to 2011. CNS+ was diagnosed on fulfillment of ≥1 of the following criteria: any L3 cerebrospinal fluid (CSF) blasts (CSF+), cranial nerve palsy, isolated intracerebral mass but also clinical spinal cord compression, and cranial or spinal parameningeal extension. Two hundred seventeen out of 1690 patients (12. Read More

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http://dx.doi.org/10.1182/bloodadvances.2019001398DOI Listing

Knockdown of lncRNA MCM3AP-AS1 Attenuates Chemoresistance of Burkitt Lymphoma to Doxorubicin Treatment via Targeting the miR-15a/EIF4E Axis.

Cancer Manag Res 2020 16;12:5845-5855. Epub 2020 Jul 16.

Department of Hematology, China-Japan Friendship Hospital, Beijing, People's Republic of China.

Purpose: The long-noncoding RNA MCM3AP-AS1 has been shown to participate in the tumorigenesis and growth of several types of cancer, but little is known about the role of MCM3AP-AS1 in the chemoresistance of lymphoma.

Methods: A series of patients with Burkitt lymphoma were enrolled for clinical analysis. Daudi and Namalwa cells were used for further experiments. Read More

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http://dx.doi.org/10.2147/CMAR.S248698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7371474PMC

Lymphotropic Viruses EBV, KSHV and HTLV in Latin America: Epidemiology and Associated Malignancies. A Literature-Based Study by the RIAL-CYTED.

Cancers (Basel) 2020 Aug 4;12(8). Epub 2020 Aug 4.

Research Unit in Virology and Cancer, Children's Hospital of Mexico Federico Gómez, 06720 Mexico City, Mexico.

The Epstein-Barr virus (EBV), Kaposi sarcoma herpesvirus (KSHV) and human T-lymphotropic virus (HTLV-1) are lymphomagenic viruses with region-specific induced morbidity. The RIAL-CYTED aims to increase the knowledge of lymphoma in Latin America (LA), and, as such, we systematically analyzed the literature to better understand our risk for virus-induced lymphoma. We observed that high endemicity regions for certain lymphomas, e. Read More

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http://dx.doi.org/10.3390/cancers12082166DOI Listing

Novel Therapies Potentially Available for Pediatric B-Cell Non-Hodgkin Lymphoma.

J Natl Compr Canc Netw 2020 Aug;18(8):1125-1134

2Roswell Park Cancer Institute, Buffalo, New York.

Burkitt lymphoma, diffuse large B-cell lymphoma (DLBCL), and primary mediastinal B-cell lymphoma are the most common aggressive pediatric mature B-cell non-Hodgkin lymphomas (B-NHLs). Despite excellent survival with current chemotherapy regimens, therapy for Burkitt lymphoma and DLBCL has a high incidence of short- and long-term toxicities. Patients who experience relapse generally have a very poor prognosis. Read More

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http://dx.doi.org/10.6004/jnccn.2020.7608DOI Listing

Pediatric Aggressive Mature B-Cell Lymphomas, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.

J Natl Compr Canc Netw 2020 Aug;18(8):1105-1123

21National Comprehensive Cancer Network.

Pediatric aggressive mature B-cell lymphomas are the most common types of non-Hodgkin lymphoma in children, and they include Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL). These diseases are highly aggressive but curable, the treatment is complex, and patients may have many complicated supportive care issues. The NCCN Guidelines for Pediatric Aggressive Mature B-Cell Lymphomas provide guidance regarding pathology and diagnosis, staging, initial treatment, disease reassessment, surveillance, therapy for relapsed/refractory disease, and supportive care for clinicians who treat sporadic pediatric BL and DLBCL. Read More

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http://dx.doi.org/10.6004/jnccn.2020.0036DOI Listing

Lytic Induction Therapy against Epstein-Barr Virus-Associated Malignancies: Past, Present, and Future.

Cancers (Basel) 2020 Aug 2;12(8). Epub 2020 Aug 2.

Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.

Epstein-Barr virus (EBV) lytic induction therapy is an emerging virus-targeted therapeutic approach that exploits the presence of EBV in tumor cells to confer specific killing effects against EBV-associated malignancies. Efforts have been made in the past years to uncover the mechanisms of EBV latent-lytic switch and discover different classes of chemical compounds that can reactivate the EBV lytic cycle. Despite the growing list of compounds showing potential to be used in the lytic induction therapy, only a few are being tested in clinical trials, with varying degrees of success. Read More

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http://dx.doi.org/10.3390/cancers12082142DOI Listing

Instant orthopnea and pseudo-cardiac dilatation due to anterior mediastinal tumor.

J Gen Fam Med 2020 Jul 29;21(4):161-162. Epub 2020 Apr 29.

Department of General Medicine Chiba University Hospital Chiba-City Japan.

A 45-year-old woman presented with instant orthopnea and enlarged cardiomediastinal silhouette in her chest radiograph. Although anterior mediastinal tumor can be misdiagnosed as heart failure due to orthopnea with enlarged cardiomediastinal silhouette, "instant orthopnea" may be a useful sign to distinguish these conditions. Read More

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http://dx.doi.org/10.1002/jgf2.324DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7388661PMC

HIV-associated Burkitt lymphoma.

Lancet Haematol 2020 Aug;7(8):e594-e600

Department of Medicine, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, New York, NY, USA. Electronic address:

Burkitt lymphoma is a rare and aggressive non-Hodgkin lymphoma with three classifications: endemic, sporadic, and immunodeficiency-related. High-intensity chemotherapeutic regimens have considerably improved overall survival for patients with Burkitt lymphoma. In this Review of HIV-associated Burkitt lymphoma, we summarise expert opinion and provide general recommendations for the treatment of Burkitt lymphoma in patients with HIV on the basis of retrospective and prospective studies, taking into consideration immune status, CD4 cell counts, the presence of systemic disease, and the risk of CNS involvement or relapse. Read More

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http://dx.doi.org/10.1016/S2352-3026(20)30126-5DOI Listing

Resection of a colonic mass following trauma: a diagnostic dilemma.

J Surg Case Rep 2020 Jul 23;2020(7):rjaa226. Epub 2020 Jul 23.

Department of Surgery, West Virginia University, Morgantown, WV 26506, USA.

A 53-year-old Caucasian male presented with a 2-week history of abdominal distension, pain, nausea and lethargy. His symptoms began 1 day after an all-terrain vehicle accident during which he suffered blunt-force trauma to his mid-right abdomen. CT scan demonstrated abnormal thickening of the ascending colon and terminal ilium with surrounding inflammation within the retroperitoneum and colonic mesentery. Read More

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http://dx.doi.org/10.1093/jscr/rjaa226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378017PMC

Endemic Burkitt lymphoma: a complication of asymptomatic malaria in sub-Saharan Africa based on published literature and primary data from Uganda, Tanzania, and Kenya.

Malar J 2020 Jul 28;19(1):239. Epub 2020 Jul 28.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.

Background: Endemic Burkitt lymphoma (eBL) is an aggressive B cell non-Hodgkin lymphoma associated with antigenic stimulation from Plasmodium falciparum malaria. Whether eBL risk is related to malaria parasite density is unknown. To address this issue, children with eBL, asymptomatic and clinical malaria, as a surrogate of malaria parasite density, were assessed. Read More

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http://dx.doi.org/10.1186/s12936-020-03312-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7385955PMC

Primary gastric lymphoma: A report of 16 pediatric cases treated at a single institute and review of the literature.

Pediatr Hematol Oncol 2020 Jul 24:1-9. Epub 2020 Jul 24.

Department of Pediatric Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Gastrointestinal tract is the most common extranodal site for childhood non-Hodgkin lymphomas (NHLs). However, primary gastric lymphoma (PGL) is very rare. We report our experience with PGL. Read More

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http://dx.doi.org/10.1080/08880018.2020.1779884DOI Listing

Cancer Risk Studies and Priority Areas for Cancer Risk Appraisal in Uganda.

Ann Glob Health 2020 Jul 7;86(1):78. Epub 2020 Jul 7.

Uganda Cancer Institute, Kampala, UG.

Background: Research into aetiologies and prevention of the commonest cancers and implementation of primary and secondary prevention can reduce cancer risk and improve quality of life. Moreover, monitoring the prevalence of cancer risk factors in a specific population helps guide cancer prevention and early detection efforts and national cancer control programming.

Objective: This article aims to provide the scope and findings of cancer risk studies conducted in Uganda to guide researchers, health-care professionals, and policymakers. Read More

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http://dx.doi.org/10.5334/aogh.2873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7350938PMC

Disseminated Burkitt lymphoma presenting as massive gastrointestinal bleed.

Proc (Bayl Univ Med Cent) 2020 Jul 20;33(3):433-435. Epub 2020 Apr 20.

Division of Digestive Diseases, Yale School of Medicine and Yale Center for PancreatitisNew HavenConnecticut.

Burkitt lymphoma is a rare, highly aggressive non-Hodgkin lymphoma with increasing incidence. Here we present a 26-year-old man with a history of a recent root canal who presented with 2 days of black, tarry stools, persistent tooth pain, and 2 weeks of fatigue, night sweats, and a 20-pound weight loss. He developed massive hematemesis while hospitalized and an esophagogastroduodenoscopy revealed innumerable, doughnut-shaped masses with central umbilication throughout the stomach, which were also the source of bleeding. Read More

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http://dx.doi.org/10.1080/08998280.2020.1747835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340431PMC

Burkitt Lymphoma as Fourth Neoplasia in a Patient Affected by Cowden Syndrome with a Novel PTEN Germline Pathogenic Variant.

Mediterr J Hematol Infect Dis 2020 1;12(1):e2020034. Epub 2020 Jul 1.

Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Roma.

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http://dx.doi.org/10.4084/MJHID.2020.034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7340242PMC

Burkitt Lymphoma in the Modern Era: Real World Outcomes and Prognostication Across 30 US Cancer Centers.

Blood 2020 Jul 14. Epub 2020 Jul 14.

University of Miami Miller School of Medicine, Miami, Florida, United States.

We examined adults with untreated Burkitt lymphoma (BL) from 2009-2018 across 30 US cancer centers. Factors associated with progression-free survival (PFS) and overall survival (OS) were evaluated in univariate and multivariate Cox models. Among 641 BL patients, baseline features included: median age 47 years; HIV+ 22%; ECOG performance status (PS) 2-4 in 23%; >1 extranodal site 43%; advanced-stage 78%; and central nervous system (CNS) involvement 19%. Read More

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http://dx.doi.org/10.1182/blood.2020006926DOI Listing
July 2020
10.452 Impact Factor

Oral manifestations related to malaria: A systematic review.

Oral Dis 2020 Jul 13. Epub 2020 Jul 13.

Department of Stomatology, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.

Objective: To generalize the oral manifestations related to malaria and discuss their clinical significance for health professionals.

Materials And Methods: The bibliographic databases of Public MEDLINE, Embase, Web of Science and Scopus were employed to retrieve publications online from January 1781 to August 2019. Original research articles, clinical trials, and case reports published in English were included. Read More

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http://dx.doi.org/10.1111/odi.13549DOI Listing

Cancer incidence and treatment utilization patterns at a regional cancer center in Tanzania from 2008-2016: Initial report of 2,772 cases.

Cancer Epidemiol 2020 Aug 10;67:101772. Epub 2020 Jul 10.

Bugando Medical Centre, Mwanza, Tanzania; Duke Global Health Institute, Duke University, Durham, NC, USA; Department of Pediatric Hematology/Oncology, Duke University, Durham, NC, USA. Electronic address:

Purpose: To describe cancer incidence and treatment utilization patterns at the regional cancer referral center for the Lake Zone of northwestern Tanzania from 2008 to 2016.

Methods: This descriptive, retrospective study reviewed all cancer cases recorded in the Bugando Cancer Registry (BCR), a clinical and pathology based registry at the only cancer referral hospital in the region. Primary tumor site, method of diagnosis, HIV status, and cancer treatment were reported. Read More

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http://dx.doi.org/10.1016/j.canep.2020.101772DOI Listing

The BCL-2 family protein inhibitor ABT-737 as an additional tool for the treatment of EBV-associated post-transplant lymphoproliferative disorders.

Mol Oncol 2020 Jul 4. Epub 2020 Jul 4.

UMR 8126, CNRS, Université Paris-Saclay, Institut Gustave Roussy, 94805, Villejuif, France.

Post-transplant lymphoproliferative disorders (PTLD) and Burkitt lymphoma (BL) are B-cell malignancies strongly associated with Epstein-Barr virus (EBV) infection. In these lymphoproliferative disorders, EBV infection induces an increase in the expression of the anti-apoptotic protein BCL-2. Given its chemoprotective effect, BCL-2 constitutes an attractive target for new therapeutic strategies for EBV-positive B-cell malignancies. Read More

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http://dx.doi.org/10.1002/1878-0261.12759DOI Listing

Dose-adjusted EPOCH-R: a feasible alternative for Burkitt lymphoma in resource-constrained settings.

Br J Haematol 2020 Jul 2. Epub 2020 Jul 2.

Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1111/bjh.16921DOI Listing
July 2020
4.711 Impact Factor

[Clinical case of IgG4-related disease in a patient with Burkitt lymphoma].

Ter Arkh 2019 Jul 15;91(7):100-105. Epub 2019 Jul 15.

Loginov Moscow Clinical Scientific and Practical Center.

The article provides a case of primary diagnosis of IgG4-related disease in a patient with Burkitt lymphoma. Read More

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http://dx.doi.org/10.26442/00403660.2019.07.000069DOI Listing

Paediatric ocular adnexal lymphoma: a population-based analysis.

BMJ Open Ophthalmol 2020 21;5(1):e000483. Epub 2020 Jun 21.

Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.

Objective: To investigate the incidence, clinicopathological characteristics and survival of ocular adnexal lymphoma (OAL) in the paediatric population.

Methods And Analysis: In this retrospective case series, the Surveillance, Epidemiology and End Results database was accessed to identify individuals with OAL ≤18 years of age, diagnosed between 1973 and 2015. OAL located in the eyelid, conjunctiva, lacrimal apparatus and orbit were included. Read More

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http://dx.doi.org/10.1136/bmjophth-2020-000483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312335PMC

Effects of HIV on the Tumor Microenvironment.

Adv Exp Med Biol 2020 ;1263:45-54

Department of Radiology, Baylor College of Medicine, Houston, TX, USA.

Oncomodulatory viruses can affect the tumor microenvironment (TME) by triggering inflammation, suppressing apoptosis, initiating angiogenesis, altering tumor metabolism, and stimulating tumor cell signaling pathways, leading to tumor growth, proliferation, and invasion. The higher incidence of malignancies among people with HIV (PWH), despite the widespread use of antiretroviral therapy (ART), suggests a more complex relation than HIV-associated immune deregulation. Viral cooperation can have synergistic effect on tumorigenesis. Read More

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http://dx.doi.org/10.1007/978-3-030-44518-8_4DOI Listing

Epstein Barr virus genomes reveal population structure and type 1 association with endemic Burkitt lymphoma.

J Virol 2020 Jun 24. Epub 2020 Jun 24.

Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA

Endemic Burkitt lymphoma (eBL), the most prevalent pediatric cancer in sub-Saharan Africa, is distinguished by its inclusion of Epstein-Barr virus (EBV). In order to better understand the impact of EBV variation in eBL tumorigenesis, we improved viral DNA enrichment methods and generated a total of 98 new EBV genomes from both eBL cases (N=58) and healthy controls (N=40) residing in the same geographic region in Kenya. Using our unbiased methods, we found that EBV type 1 was significantly more prevalent in eBL patients (74. Read More

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http://dx.doi.org/10.1128/JVI.02007-19DOI Listing

The Locus of Epstein-Barr Virus Contributes to Viral Latency and B-Cell Immortalization.

J Virol 2020 Jun 24. Epub 2020 Jun 24.

Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, and the Penn State Hershey Cancer Institute, Hershey, Pennsylvania, U.S.A.

The Epstein-Barr virus (EBV) gene encodes an abundant linear and several circular RNAs believed to perform non-coding functions during virus replication, though an open reading frame is retained among an unknown percentage of EBV isolates. Evidence suggests that is also transcribed during latent infection, which prompted us to investigate the contribution of this locus to latency. Analysis of transcripts transiting revealed its transcription is widespread among B-cell lines supporting the latency I or III program of EBV protein expression, and to be more complex than originally presumed. Read More

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http://dx.doi.org/10.1128/JVI.01215-20DOI Listing

Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Children With Non-Hodgkin Lymphoma.

J Pediatr Hematol Oncol 2020 Jul;42(5):e310-e314

Departments of Pediatric Hematology and Oncology.

The aim of this study is to evaluate the clinical and laboratory findings of pediatric patients with non-Hodgkin lymphoma (NHL) who developed Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Between 2006 and 2018, the medical records of child patients with NHL who developed SJS and TEN were reviewed retrospectively. SJS/TEN developed in 7 of 70 patients with NHL (10%). Read More

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http://dx.doi.org/10.1097/MPH.0000000000001851DOI Listing

Endoscopic detection of the lead-point of intussusception associated with ileal Burkitt's lymphoma.

Dig Liver Dis 2020 Jun 16. Epub 2020 Jun 16.

Department of Pathology, Takatsuki General Hospital, Takatsuki, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.dld.2020.05.033DOI Listing

[Burkitt’s lymphoma of the skull calotte: a case report].

Rev Fac Cien Med Univ Nac Cordoba 2020 04 14;77(2):106-109. Epub 2020 Apr 14.

Grupo de Investigación Continental, Universidad Continental. Lima, Perú..

Introduction: Burkitt’s lymphoma is a non- Hodgkin B-cell lymphoma whose cranial location is extremely rare.

Clinical Case: The case of a 35-year-old Peruvian man with a progressive parietal left cranial tumor is described. A biopsy with immunohistochemistry was performed for the diagnostic confirmation of Burkitt’s lymphoma. Read More

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http://dx.doi.org/10.31053/1853.0605.v77.n2.26764DOI Listing

[Effect of Modified LMB 89± Rituximab Regimen on Long-Term Benefits for Patients's with Burkitt Lymphoma].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2020 Jun;28(3):872-875

Department of Hematology, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, Yunnan Province, China,E-mail:

Objective: To investigate the effect of modified LMB 89± rituximab regimen on long-term clinical benefit for patients with Burkitt lymphoma.

Methods: Clinical data of 43 patients with Burkitt lymphoma were collected and retrospectively analyzed in the period from July 2006 to October 2017. Forty-three patients were divided into 2 groups, including Hyper-CVAD regimen, R-EPOCD regimen or VDCLP regimen treated group as control (20 patients) and modified regimen group with modified LMB 89±rituximab regimen (23 patients); the event-free survival (EFS) rate, overall survival (OS) rate, cumulative incidence of relapse (CIR), non-relapse mortality rate (NRM) and adverse reaction incidence of 2 groups were compared. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2020.03.025DOI Listing

[Clinical Characteristics of 219 Patients with Primary Gastrointestinal Non-Hodgkin's Lymphoma].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2020 Jun;28(3):849-854

Department of Hematology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060,

Objective: To analyze the clinical and pathological characteristics of primary gastrointestinal non-Hodgkin's lymphoma (PGI-NHL) patients, and to explore the factors affecting the patients' survival and prognosis.

Methods: The clinical data of 219 patients with PGI-NHL diagnosed in our hospital from March 2009 to April 2016 was collected and retrospectively analyzed. Survival analysis was performed by using the Kaplan-Meier method. Read More

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http://dx.doi.org/10.19746/j.cnki.issn.1009-2137.2020.03.021DOI Listing

EBNA2-deleted Epstein-Barr virus (EBV) isolate, P3HR1, causes Hodgkin-like lymphomas and diffuse large B cell lymphomas with type II and Wp-restricted latency types in humanized mice.

PLoS Pathog 2020 06 15;16(6):e1008590. Epub 2020 Jun 15.

Department of Oncology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

EBV transforms B cells in vitro and causes human B-cell lymphomas including classical Hodgkin lymphoma (CHL), Burkitt lymphoma (BL) and diffuse large B-cell lymphoma (DLBCL). The EBV latency protein, EBNA2, transcriptionally activates the promoters of all latent viral protein-coding genes expressed in type III EBV latency and is essential for EBV's ability to transform B cells in vitro. However, EBNA2 is not expressed in EBV-infected CHLs and BLs in humans. Read More

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http://dx.doi.org/10.1371/journal.ppat.1008590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316346PMC

High-dose methotrexate in ICU patients: a retrospective study.

Ann Intensive Care 2020 Jun 13;10(1):81. Epub 2020 Jun 13.

Medical ICU, APHP, Saint-Louis Hospital, Paris, France.

Background: High-dose methotrexate (HD-MTX) is commonly used in the treatment of solid tumors and hematological malignancies. Severe toxicities are frequent, leading to organ dysfunction and death. Risk-benefit ratio of using HD-MTX in critically ill patients is unknown. Read More

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http://dx.doi.org/10.1186/s13613-020-00693-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293713PMC

Genetic progression of post-transplant Burkitt-like lymphoma case with 11q-Gain/Loss and MYC amplification.

Cancer Genet 2020 Jul 18;245:1-5. Epub 2020 May 18.

Cytogenetic Laboratory, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.

"Burkitt-like lymphoma with 11q aberration" is a new provisional entity in the latest revision of lymphoma's World Health Organization classification described as carrying the specific 11q-gain/loss aberration and lacking MYC rearrangement. Morphologically, phenotypically and by gene and microRNA expression profiling these lymphomas resemble Burkitt lymphoma. The 11q-gain/loss was also found in post-transplant patients with molecular Burkitt lymphoma signature without MYC rearrangement. Read More

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http://dx.doi.org/10.1016/j.cancergen.2020.05.001DOI Listing
July 2020
2.417 Impact Factor

Primary Paraspinal and Spinal Epidural Non-Hodgkin Lymphoma in Childhood.

J Pediatr Hematol Oncol 2020 Jun 9. Epub 2020 Jun 9.

Department of Pediatric Oncology, Hacettepe University Faculty of Medicine.

Primary paraspinal/spinal epidural lymphoma (PPSEL) is rare in childhood. Here, we retrospectively evaluated patients with PPSEL treated in our department. We also reviewed the cases reported in the literature. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001858DOI Listing

The miR-26b-5p/KPNA2 Axis Is an Important Regulator of Burkitt Lymphoma Cell Growth.

Cancers (Basel) 2020 Jun 4;12(6). Epub 2020 Jun 4.

Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, 9700RB Groningen, The Netherlands.

The expression of several microRNAs (miRNAs) is known to be changed in Burkitt lymphoma (BL), compared to its normal counterparts. Although for some miRNAs, a role in BL was demonstrated, for most of them, their function is unclear. In this study, we aimed to identify miRNAs that control BL cell growth. Read More

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http://dx.doi.org/10.3390/cancers12061464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352454PMC

Clinical manifestations of oral lymphomas - Retrospective study of 15 cases in a Taiwanese population and a review of 592 cases from the literature.

J Formos Med Assoc 2020 Jun 3. Epub 2020 Jun 3.

Division of Oral Pathology & Maxillofacial Radiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Oral & Maxillofacial Imaging Center, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Division of Oral & Maxillofacial Surgery, Kaohsiung Medical University Hospital Kaohsiung, Taiwan. Electronic address:

Background/purpose: Due to the rarity of oral lymphoma (OL), we aimed to evaluate the clinical features of OL and discuss these findings in light of the literature.

Methods: English language literature (1980-2019) related to OL was searched in two electronic databases. Patients (2000-2019) diagnosed with OL were also selected from the database of the Oral Pathology Department in our institution. Read More

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http://dx.doi.org/10.1016/j.jfma.2020.05.025DOI Listing

Contribution of immunophenotype to the investigation and differential diagnosis of Burkitt lymphoma, double-hit high-grade B-cell lymphoma, and single-hit MYC-rearranged diffuse large B-cell lymphoma.

Cytometry B Clin Cytom 2020 Jun 4. Epub 2020 Jun 4.

Flow Cytometry Laboratory, Department of Immunology, Athens Regional General Hospital Georgios Gennimatas, Athens, Greece.

Background: There are no immunophenotypic guidelines for the investigation of MYC-rearranged lymphomas. We aimed to identify simple immunophenotypic features that would help to differentiate between MYC-rearranged lymphomas and guide cytogenetic analysis.

Methods: We reviewed diagnostic samples from patients diagnosed with Burkitt lymphoma (BL), double-hit lymphoma (DHL), MYC-rearranged diffuse large B-cell lymphoma (MYC-DLBCL), and standard (non-MYC-rearranged) DLBCL over the last decade in our Institution. Read More

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http://dx.doi.org/10.1002/cyto.b.21887DOI Listing

HIV Lymphoma and Burkitts Lymphoma.

Authors:
Ariela Noy

Cancer J 2020 May/Jun;26(3):260-268

From the Department of Medicine, Memorial Sloan Kettering Cancer Center; and Weill Cornell Medical College, New York, NY.

Despite widely available antiretroviral therapy, lymphoma remains the leading cause of death for human immunodeficiency virus (HIV)-infected persons in economically developed countries. Even a few months of drug interruptions can lead to drops in the CD4 cell count, HIV viremia, and an increased risk of lymphoma. Currently, good HIV control facilitates intensive therapies appropriate to the lymphoma, including autologous and even allogeneic hematopoietic stem cell transplantation. Read More

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http://dx.doi.org/10.1097/PPO.0000000000000448DOI Listing

Burkitt lymphoma initially mimicking varicella zoster infection.

IDCases 2020 14;21:e00818. Epub 2020 May 14.

Hematology Unit, Medical Specialty Center, Bangkok Hospital Hat Yai, Bangkok Dusit Medical Services, Hat Yai, Songkhla, Thailand.

Burkitt lymphoma is an aggressive type of nodal non-Hodgkin lymphoma. This disease commonly involves the gastrointestinal tract, bone marrow, central nervous system, and in rare instances, the skin. We report the case of a 78-year-old Asian man who had experienced subacute fever and significant weight loss. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256308PMC

Epidemiology of adult and pediatric Burkitt lymphoma in Canada: sequelae of the HIV epidemic.

Curr Oncol 2020 04 1;27(2):83-89. Epub 2020 May 1.

Division of Dermatology, McGill University, Montreal, QC.

Background: Although the pathogenesis and epidemiology of endemic Burkitt lymphoma (bl) have been extensively studied, the epidemiologic landscape of sporadic and immunodeficiency-associated bl in North America remains poorly understood.

Methods: We used 3 distinct population-based cancer registries to retrospectively study bl incidence and mortality in Canada. Data for patient sex; age at the time of diagnosis; and reporting province, city, and forward sortation area (fsa, the first three characters of a postal code) were analyzed. Read More

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http://dx.doi.org/10.3747/co.27.5775DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253744PMC

Frequent traces of EBV infection in Hodgkin and non-Hodgkin lymphomas classified as EBV-negative by routine methods: expanding the landscape of EBV-related lymphomas.

Mod Pathol 2020 Jun 1. Epub 2020 Jun 1.

Section of Pathology, Department of Medical Biotechnology, University of Siena, Siena, Italy.

The Epstein-Barr virus (EBV) is linked to various B-cell lymphomas, including Burkitt lymphoma (BL), classical Hodgkin lymphoma (cHL) and diffuse large B-cell lymphoma (DLBCL) at frequencies ranging, by routine techniques, from 5 to 10% of cases in DLBCL to >95% in endemic BL. Using higher-sensitivity methods, we recently detected EBV traces in a few EBV-negative BL cases, possibly suggesting a "hit-and-run" mechanism. Here, we used routine and higher-sensitivity methods (qPCR and ddPCR for conserved EBV genomic regions and miRNAs on microdissected tumor cells; EBNA1 mRNA In situ detection by RNAscope) to assess EBV infection in a larger lymphoma cohort [19 BL, 34 DLBCL, 44 cHL, 50 follicular lymphomas (FL), 10 T-lymphoblastic lymphomas (T-LL), 20 hairy cell leukemias (HCL), 10 mantle cell lymphomas (MCL)], as well as in several lymphoma cell lines (9 cHL and 6 BL). Read More

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http://dx.doi.org/10.1038/s41379-020-0575-3DOI Listing

Mechanisms of B Cell Receptor Activation and Responses to B Cell Receptor Inhibitors in B Cell Malignancies.

Cancers (Basel) 2020 May 28;12(6). Epub 2020 May 28.

Department of Hematology, Fondazione Policlinico Universitario A Gemelli IRCCS, 00168 Rome, Italy.

The B cell receptor (BCR) pathway has been identified as a potential therapeutic target in a number of common B cell malignancies, including chronic lymphocytic leukemia, diffuse large B cell lymphoma, Burkitt lymphoma, follicular lymphoma, mantle cell lymphoma, marginal zone B cell lymphoma, and Waldenstrom's macroglobulinemia. This finding has resulted in the development of numerous drugs that target this pathway, including various inhibitors of the kinases BTK, PI3K, and SYK. Several of these drugs have been approved in recent years for clinical use, resulting in a profound change in the way these diseases are currently being treated. Read More

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http://dx.doi.org/10.3390/cancers12061396DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7352865PMC

BI6727, a polo-like kinase 1 inhibitor with promising efficacy on Burkitt lymphoma cells.

Authors:
Er Chen Renzhi Pei

J Int Med Res 2020 May;48(5):300060520926093

The First Clinical Medical College, Wenzhou Medical University, Wenzhou, Zhejiang, P.R. China.

Objective: BI6727, an ATP-competitive PLK1 inhibitor, has been shown to cause cell death in multi-tumors. This study aimed to investigate the anti-tumor effect and potential molecular mechanism of BI6727 in human Burkitt lymphoma (BL) cell lines.

Methods: We assessed polo-like kinase 1 (PLK1) expression in BL patient tissues and cells, also investigated the cytotoxic effect using CCK8 assay and flow cytometry. Read More

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http://dx.doi.org/10.1177/0300060520926093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7263168PMC

Favourable outcomes for high-risk diffuse large B-cell lymphoma (IPI 3-5) treated with front-line R-CODOX-M/R-IVAC chemotherapy: results of a phase 2 UK NCRI trial.

Ann Oncol 2020 May 26. Epub 2020 May 26.

Haematology Department, University College Hospital London, London, UK; UCL Cancer Institute, University College London, UK.

Background: Outcomes for patients with high-risk diffuse large B-cell lymphoma (DLBCL) treated with R-CHOP chemotherapy are suboptimal but, to date, no alternative regimen has been shown to improve survival rates. This phase 2 trial aimed to assess the efficacy of a Burkitt-like approach for high-risk DLBCL using the dose-intense R-CODOX-M/R-IVAC regimen.

Patients And Methods: Eligible patients were aged 18-65 years with stage II-IV untreated DLBCL and an International Prognostic Index (IPI) score of 3-5. Read More

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http://dx.doi.org/10.1016/j.annonc.2020.05.016DOI Listing

Biological Difference Between Epstein-Barr Virus Positive and Negative Post-transplant Lymphoproliferative Disorders and Their Clinical Impact.

Front Oncol 2020 8;10:506. Epub 2020 May 8.

Hematology Division, IRCCS Ca' Granda-Maggiore Policlinico Hospital Foundation, Milan, Italy.

Epstein-Barr virus (EBV) infection is correlated with several lymphoproliferative disorders, including Hodgkin disease, Burkitt lymphoma, diffuse large B-cell lymphoma (DLBCL), and post-transplant lymphoproliferative disorder (PTLD). The oncogenic EBV is present in 80% of PTLD. EBV infection influences immune response and has a causative role in the oncogenic transformation of lymphocytes. Read More

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http://dx.doi.org/10.3389/fonc.2020.00506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225286PMC