11,957 results match your criteria Burkitt Lymphoma


Inhibition of the PI3K/AKT signaling pathway sensitizes diffuse large B-cell lymphoma cells to treatment with proteasome inhibitors via suppression of BAG3.

Oncol Lett 2019 Apr 8;17(4):3719-3726. Epub 2019 Feb 8.

Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China.

Proteasome inhibitors represent a novel class of drugs that have clinical efficacy against hematological and solid cancer types, including acute myeloid leukaemia, myelodysplastic syndrome an non-small cell lung cancer. It has been demonstrated that the anti-apoptotic protein B-cell lymphoma-2-associated athanogene 3 (BAG3) is induced by proteasome inhibitors in various cancer cells and serves an important role in chemotherapy resistance. The phosphatidylinositol 3-kinase (PI3K)/RAC-α serine/threonine-protein kinase (AKT) pathway is constitutively activated in a number of lymphoid malignancy types, including diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma. Read More

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http://dx.doi.org/10.3892/ol.2019.10029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403502PMC

Molecular pathogenesis of germinal center-derived B cell lymphomas.

Immunol Rev 2019 Mar;288(1):240-261

Pathology and Cell Biology, Institute for Cancer Genetics, Columbia University, New York City, New York.

B cell lymphomas comprise a heterogeneous group of genetically, biologically, and clinically distinct neoplasms that, in most cases, originate from the clonal expansion of B cells in the germinal center (GC). In recent years, the advent of novel genomics technologies has revolutionized our understanding of the molecular pathogenesis of lymphoid malignancies as a multistep process that requires the progressive accumulation of multiple genetic and epigenetic alterations. A common theme that emerged from these studies is the ability of lymphoma cells to co-opt the same biological programs and signal transduction networks that operate during the normal GC reaction, and misuse them for their own survival advantage. Read More

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http://dx.doi.org/10.1111/imr.12745DOI Listing

Viral-Targeted Strategies Against EBV-Associated Lymphoproliferative Diseases.

Front Oncol 2019 26;9:81. Epub 2019 Feb 26.

Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, The University of Hong Kong, Hong Kong, Hong Kong.

Epstein-Barr virus (EBV) is strongly associated with a spectrum of EBV-associated lymphoproliferative diseases (EBV-LPDs) ranging from post-transplant lymphoproliferative disorder, B cell lymphomas (e.g., endemic Burkitt lymphoma, Hodgkin lymphoma, and diffuse large B cell lymphoma) to NK or T cell lymphoma (e. Read More

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http://dx.doi.org/10.3389/fonc.2019.00081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400835PMC
February 2019

Genetic signatures of gene flow and malaria-driven natural selection in sub-Saharan populations of the "endemic Burkitt Lymphoma belt".

PLoS Genet 2019 Mar 8;15(3):e1008027. Epub 2019 Mar 8.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, Maryland, United States of America.

Populations in sub-Saharan Africa have historically been exposed to intense selection from chronic infection with falciparum malaria. Interestingly, populations with the highest malaria intensity can be identified by the increased occurrence of endemic Burkitt Lymphoma (eBL), a pediatric cancer that affects populations with intense malaria exposure, in the so called "eBL belt" in sub-Saharan Africa. However, the effects of intense malaria exposure and sub-Saharan populations' genetic histories remain poorly explored. Read More

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http://dx.plos.org/10.1371/journal.pgen.1008027
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http://dx.doi.org/10.1371/journal.pgen.1008027DOI Listing
March 2019
4 Reads

The first reported case of vincristine-induced unilateral vocal cord palsy in an adult patient with HIV-associated Burkitt-like lymphoma being treated with dose-escalated R-EPOCH.

Clin Case Rep 2019 Feb 18;7(2):272-274. Epub 2018 Dec 18.

Department of Hematology and Oncology, D'Amour Center for Cancer Care, Baystate Medical Center University of Massachusetts Springfield Massachusetts.

Vincristine-induced vocal cord palsy (VCP) is a rare but critical complication. Prompt recognition of VCP is imperative. Vincristine-induced VCP is reversible, and a complete remission of a lymphoma is still feasible upon withdrawal of vincristine from the chemotherapeutic regimen early in the course of treatment. Read More

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http://dx.doi.org/10.1002/ccr3.1964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389462PMC
February 2019
2 Reads

Paediatric burkitt lymphoma presenting as a mandible swelling and intussusception.

Med J Malaysia 2019 Feb;74(1):90-91

Universiti Sains Malaysia, School of Medical Sciences, Department of Otorhinolaryngology - Head & Neck Surgery, Health Campus, Kota Bharu, Kelantan, Malaysia.

Burkitt lymphoma is a rare entity especially in this part of the world. We had an 11-year-old patient presented with swelling of the mandible for a short one-month duration. He was planned for excision biopsy. Read More

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February 2019
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High-grade B-cell lymphoma relapse presenting as neurolymphomatosis of the median nerve.

BMJ Case Rep 2019 Mar 6;12(3). Epub 2019 Mar 6.

Department of Radiology, Austin Hospital, Heidelberg, Victoria, Australia.

Neurolymphomatosis (NL) is the infiltration of lymphocytes into the peripheral nervous system in a haematological malignancy. We describe the imaging features of NL in a patient with relapsed Burkitt-like non-Hodgkin's lymphoma on positron emission tomography (PET) and ultrasound. Imaging features on ultrasound are infrequently described and provide useful information in helping to establish an imaging diagnosis of NL. Read More

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http://dx.doi.org/10.1136/bcr-2018-228742DOI Listing
March 2019
1 Read

Management of adults with Burkitt lymphoma.

Clin Adv Hematol Oncol 2018 Dec;16(12):812-822

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.

Burkitt lymphoma (BL) is a highly aggressive B-cell non-Hodgkin lymphoma characterized by marked tumor proliferation resulting from translocation of the MYC oncogene. Distinct clinical variants include endemic, sporadic, and immunodeficiency-associated cases. All variants are characterized by rapidly dividing tumor masses that quickly disseminate to extranodal sites, including the bone marrow and central nervous system (CNS). Read More

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December 2018
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A population-based study of the prevalence and risk-factors of low-grade Plasmodium falciparum malaria infection in children aged 0-15 years old in northern Tanzania.

Trop Med Int Health 2019 Mar 7. Epub 2019 Mar 7.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.

Objectives: Tanzania experiences significant malaria-related morbidity and mortality, but accurate data are scarce. We update the data on patterns of low-grade Plasmodium falciparum malaria infection among children in northern Tanzania.

Methods: P. Read More

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http://dx.doi.org/10.1111/tmi.13225DOI Listing
March 2019
1 Read

S-Geranylgeranyl-L-glutathione is a ligand for human B cell-confinement receptor P2RY8.

Nature 2019 Mar 6;567(7747):244-248. Epub 2019 Mar 6.

Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, San Francisco, CA, USA.

Germinal centres are important sites for antibody diversification and affinity maturation, and are also a common origin of B cell malignancies. Despite being made up of motile cells, germinal centres are tightly confined within B cell follicles. The cues that promote this confinement are incompletely understood. Read More

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http://dx.doi.org/10.1038/s41586-019-1003-zDOI Listing
March 2019
4 Reads

Targeting Burkitt lymphoma with a tumor cell-specific heptamethine carbocyanine-cisplatin conjugate.

Cancer 2019 Mar 6. Epub 2019 Mar 6.

Department of Medicine, Uro-Oncology Research Program, Cedars-Sinai Medical Center, Los Angeles, California.

Background: Burkitt lymphoma is a fast-growing mature B cell malignancy, whose genetic hallmark is translocation and activation of the c-myc gene. Prompt multiagent immunochemotherapy regimens can have favorable outcomes, but prognosis is poor in refractory or relapsed disease. We previously identified a novel family of near-infrared heptamethine carbocyanine fluorescent dyes (HMCD or DZ) with tumor-homing properties via organic anion-transporting peptides. Read More

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http://dx.doi.org/10.1002/cncr.32033DOI Listing
March 2019
2 Reads
4.889 Impact Factor

The cost effectiveness of treating Burkitt lymphoma in Uganda.

Cancer 2019 Mar 6. Epub 2019 Mar 6.

Fred Hutchinson Cancer Research Center, Seattle Children's Hospital, Seattle, Washington.

Background: Perceptions of high cost and resource intensity remain political barriers to the prioritization of childhood cancer treatment programs in many low- and middle-income countries (LMICs). Little knowledge exists of the actual cost and cost-effectiveness of such programs. To improve outcomes for children with Burkitt lymphoma (BL), the most common childhood cancer in Africa, the Uganda Cancer Institute implemented a comprehensive BL treatment program in 2012. Read More

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http://dx.doi.org/10.1002/cncr.32006DOI Listing
March 2019
4.889 Impact Factor

The interaction between Vav1 and EBNA1 promotes survival of Burkitt's lymphoma cells by down-regulating the expression of Bim.

Biochem Biophys Res Commun 2019 Mar 1. Epub 2019 Mar 1.

Key Laboratory of Microbial Functional Genomics of the Ministry of Education, College of Life Sciences, Nankai University, Tianjin, China; Tianjin Key Laboratory of Protein Sciences, College of Life Sciences, Nankai University, Tianjin, China. Electronic address:

Vav1 is a guanine nucleotide exchange factor (GEF) predominantly expressed in hematopoietic cells, and functions in the development and antigen-stimulated response of lymphocytes. Burkitt's lymphoma (BL) is characterized as transformed B cell lymphoma, and is highly associated with Epstein-Barr virus (EBV). EBV nuclear antigen 1 (EBNA1) is the only viral protein expressed across all three types of latency and essential for the persistence of EBV genome. Read More

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http://dx.doi.org/10.1016/j.bbrc.2019.02.108DOI Listing
March 2019
2 Reads

Association of immunosuppression and HIV viraemia with non-Hodgkin lymphoma risk overall and by subtype in people living with HIV in Canada and the USA: a multicentre cohort study.

Lancet HIV 2019 Feb 27. Epub 2019 Feb 27.

Department of Environmental Health Sciences, Yale School of Public Health, Yale School of Medicine, New Haven, CT, USA.

Background: Research is needed to better understand relations between immunosuppression and HIV viraemia and risk for non-Hodgkin lymphoma, a common cancer in people living with HIV. We aimed to identify key CD4 count and HIV RNA (viral load) predictors of risk for non-Hodgkin lymphoma, overall and by subtype.

Methods: We studied people living with HIV during 1996-2014 from 21 Canadian and US cohorts participating in the North American AIDS Cohort Collaboration on Research and Design. Read More

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http://dx.doi.org/10.1016/S2352-3018(18)30360-6DOI Listing
February 2019
1 Read

Molecular tumor analysis and liquid biopsy: a feasibility investigation analyzing circulating tumor DNA in patients with central nervous system lymphomas.

BMC Cancer 2019 Mar 1;19(1):192. Epub 2019 Mar 1.

Center for Genomics and Transcriptomics (CeGaT) GmbH, Tübingen, Germany.

Background: Central nervous system lymphomas (CNSL) is a devastating disease. Currently, a confirmatory biopsy is required prior to treatment.

Objective: Our investigation aims to prove the feasibility of a minimally-invasive diagnostic approach for the molecular characterization of CNSL. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5394-xDOI Listing
March 2019
3 Reads

A new Burkitt "look-alike" lymphoma.

Authors:
Mitchell S Cairo

Blood 2019 Feb;133(9):889-891

New York Medical College.

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http://dx.doi.org/10.1182/blood-2019-01-894329DOI Listing
February 2019

Sex ratio among childhood cancers by single year of age.

Pediatr Blood Cancer 2019 Feb 28:e27620. Epub 2019 Feb 28.

Division of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.

Background: The male excess in childhood cancer incidence is well-established; however, the underlying biologic mechanisms remain unknown. Examining the association between male sex and childhood cancer by single year of age and tumor type may highlight important periods of risk such as variation in growth and hormonal changes, which will inform etiologic hypotheses.

Methods: Using data from the Surveillance, Epidemiology, and End Results (SEER) 18 registries (2000-2015), incidence rate ratios (IRR) and 95% confidence intervals (95% CI) were estimated as the measure of association between male sex and childhood cancer by single year of age (0-19). Read More

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http://dx.doi.org/10.1002/pbc.27620DOI Listing
February 2019
1 Read

Autologous stem cell transplantation for HIV-associated lymphoma in the antiretroviral and rituximab era: a retrospective study by the EBMT Lymphoma Working Party.

Bone Marrow Transplant 2019 Feb 25. Epub 2019 Feb 25.

University Hospital of Heidelberg, Heidelberg, Germany.

The present study aimed at describing the outcome of patients with HIV-associated lymphomas following autologous hematopoietic stem cell transplantation (autoHCT) in the rituximab and combined antiretroviral therapy (cART) era. Eligible for this retrospective study were HIV-positive patients with lymphoma who received autoHCT between 2007 and 2013. A total of 118 patients were included with a median age of 45 years (range 24-66). Read More

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http://dx.doi.org/10.1038/s41409-019-0480-xDOI Listing
February 2019
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Prospective study of Burkitt lymphoma treatment in adolescents and adults in Malawi.

Blood Adv 2019 Feb;3(4):612-620

University of North Carolina Project-Malawi, Lilongwe, Malawi.

Burkitt lymphoma (BL) is common in sub-Saharan Africa (SSA). In high-income countries, BL is highly curable with chemotherapy. However, there are few prospective studies from SSA describing nonpediatric BL and no regional standard of care. Read More

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http://dx.doi.org/10.1182/bloodadvances.2018029199DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391663PMC
February 2019
1 Read

Prognostic role of ΔMTV and ΔTLG in Burkitt lymphoma.

Ann Nucl Med 2019 Feb 20. Epub 2019 Feb 20.

Nuclear Medicine, University of Brescia and Spedali Civili di Brescia, P.le Spedali Civili, 1, 25123, Brescia, Italy.

Objective: Burkitt's lymphoma (BL) is an aggressive lymphoma sub-type with high 18F-FDG avidity, but no well established evidence of PET/CT's role in treatment evaluation or prognosis is currently available. The prognostic role of visual analysis and Deauville criteria for BL have already been demonstrated, while the potential usefulness of semi-quantitative PET/CT features remains unclear, especially the value of the rate of reduction in metabolic tumor volume (MTV) and total lesion glycolysis (TLG). The aim of this retrospective study was to investigate whether ΔMTV and ΔTLG can predict treatment response at the end of therapy and prognosis in BL. Read More

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http://dx.doi.org/10.1007/s12149-019-01338-9DOI Listing
February 2019

Adult Burkitt lymphoma- an Island between lymphomas and leukemias.

J Community Hosp Intern Med Perspect 2019 11;9(1):25-28. Epub 2019 Feb 11.

Department of Internal Medicine, Hackensack Meridian Health- Ocean Medical Centre, Brick, NJ, USA.

: Burkitt lymphoma is a rare, aggressive and rapidly fatal, B-cell non-Hodgkin's lymphoma. It has an incidence of 0.4/100,000 age-adjusted to the USA standard population. Read More

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https://www.tandfonline.com/doi/full/10.1080/20009666.2019.1
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http://dx.doi.org/10.1080/20009666.2019.1574545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374956PMC
February 2019
2 Reads

A recurrent clonally distinct burkitt lymphoma case highlights genetic key events contributing to oncogenesis.

Genes Chromosomes Cancer 2019 Feb 18. Epub 2019 Feb 18.

INSERM U1245, Centre Henri Becquerel and Rouen University, Rouen, France.

Burkitt lymphoma (BL) is characterized by a translocation of the MYC oncogene that leads to the upregulation of MYC expression, cell growth and proliferation. It is well-established that MYC translocation is not a sufficient genetic event to cause BL. Next-generation sequencing has recently provided a comprehensive analysis of the landscape of additional genetic events that contribute to BL lymphomagenesis. Read More

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http://doi.wiley.com/10.1002/gcc.22743
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http://dx.doi.org/10.1002/gcc.22743DOI Listing
February 2019
1 Read

Predictable and Unusual Adverse Effects of Immunosuppression in Pediatric Liver Transplant Patients.

Exp Clin Transplant 2019 01;17(Suppl 1):230-233

From the Department of Pediatric Gastroenterology,Gazi University Faculty of Medicine, Ankara, Turkey.

Objectives: Our aim was to determine potentially adverse effects of immunosuppressive protocols after liver transplantation in children.

Materials And Methods: The medical records of 60 children who underwent liver transplant retrospectively analyzed. Corticosteroid, tacrolimus, and mycophenolate mofetil were the primary immunosuppressive agents used in our center. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P81DOI Listing
January 2019
3 Reads

[Retrospective study about 20 cases of ovarian Burkitt lymphoma at Yopougon teaching hospital in Côte d'Ivoire].

Bull Cancer 2019 Mar 14;106(3):275-278. Epub 2019 Feb 14.

CHU de Yopougon Abidjan, service d'hématologie, 04 BP 1439, Abidjan 04, Côte d'Ivoire.

Context: The maxillo-facial attack was the first described in the Burkitt lymphoma in 1958 by Denis Pearsons Burkitt. Abdominopelvic disorders, particularly ovarian localization are observed more and more by the developments of imagery technics. Our study aimed to describe the epidemiologic, clinical, therapeutic and evolutive aspects of ovarian localization in the endemic Burkitt lymphoma. Read More

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http://dx.doi.org/10.1016/j.bulcan.2018.12.011DOI Listing
March 2019
1 Read

Oocyte cryopreservation for a female cancer patient after reaching adulthood.

Pediatr Int 2019 Feb 11;61(2):207-208. Epub 2019 Feb 11.

Departments of Human Health Science, Graduate School of Medicine, Kyoto University, Sakyo, Kyoto, Japan.

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http://dx.doi.org/10.1111/ped.13752DOI Listing
February 2019
1 Read

Optimizing outcomes for children with non-Hodgkin lymphoma in low- and middle-income countries by early correct diagnosis, reducing toxic death and preventing abandonment.

Br J Haematol 2019 Feb 10. Epub 2019 Feb 10.

University of Tennessee Health Science Center, Memphis, TN, USA.

In high-income countries, more than 90% of children with mature B-cell lymphomas are cured with frontline therapy. However, cure requires prompt and correct diagnosis, careful risk stratification, very intense chemotherapy and meticulous supportive care, together with logistical support for patients who live far from the cancer centre or face financial barriers to receiving care. In low- and middle-income countries (LMIC), cure rates range from 20% to 70% because of lack of diagnosis, misdiagnosis, abandonment of treatment, toxic death and excess relapse with reduced-intensity regimens. Read More

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http://dx.doi.org/10.1111/bjh.15785DOI Listing
February 2019
1 Read

Bright CD38 Expression by Flow Cytometric Analysis Is a Biomarker for Double/Triple Hit Lymphomas with a Moderate Sensitivity and High Specificity.

Cytometry B Clin Cytom 2019 Feb 7. Epub 2019 Feb 7.

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas.

Background: High-grade B-cell lymphomas (HGBCL) with MYC and BCL2 or/and BCL6 rearrangements (R), so-called double/triple-hit lymphomas (DH/THL), are uncommon, clinically aggressive lymphomas that require a prompt diagnosis. We aim to identify flow cytometric immunophenotypic (IP) features of DH/THL that may aid in triaging these cases followed by a timely confirmatory cytogenetic study.

Methods: We compared the IP features of 43 cases of DH/THL to those of 55 cases of single-hit lymphoma (SHL) and 59 cases of diffuse large B-cell lymphoma (DLBCL) without MYC-R (MYC DLBCL). Read More

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http://dx.doi.org/10.1002/cyto.b.21770DOI Listing
February 2019
2 Reads

Pediatric non-Hodgkin lymphoma: Characteristics, stratification, and treatment at a single institute in Thailand.

Pediatr Int 2019 Jan;61(1):49-57

Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Background: In the modern era of chemotherapy, the outcome of pediatric non-Hodgkin lymphoma (NHL) continues to improve internationally. Limited data such as information on epidemiology and survival, however, are available in Asian countries.

Methods: Children (≤15 years old) diagnosed with histologically proven NHL from 1998 to 2014 were retrospectively analyzed. Read More

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http://dx.doi.org/10.1111/ped.13739DOI Listing
January 2019
1 Read

Burkitt-like lymphoma with 11q aberration: A germinal center derived lymphoma genetically unrelated to Burkitt lymphoma.

Haematologica 2019 Feb 7. Epub 2019 Feb 7.

Institut Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain;

Burkitt-like lymphoma with 11q aberration is characterized by pathological features and gene expression profile resembling Burkitt lymphoma but lack MYC rearrangement and carries an 11q-arm aberration with proximal gains and telomeric losses. Whether these lymphomas are a distinct category or a particular variant of other recognized entities is controversial. To improve the understanding of Burkitt-like lymphoma with 11q aberration we have performed an analysis of copy number alterations and targeted sequencing of a large panel of B-cell lymphoma related genes in 11 cases. Read More

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http://dx.doi.org/10.3324/haematol.2018.207928DOI Listing
February 2019
1 Read
5.868 Impact Factor

Methenamine's journey of 160 years: Repurposal of an old urinary antiseptic for treatment and hypoxic radiosensitization of cancers and glioblastoma.

Clin Exp Pharmacol Physiol 2019 Feb 5. Epub 2019 Feb 5.

Department of Neurosurgery, Acibadem University, Istanbul, Turkey.

Methenamine (hexamethylenetetramine, hexamine, urotropine) is a compound discovered in 1859, which is still currently being used as a urinary antiseptic. Methenamine is highly soluble in water and polar solvents, and its molecular constitution is similar to adamantane compounds with tetrahedral cage like structure. In acidic conditions, methenamine decomposes to formaldehyde and ammonia. Read More

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http://dx.doi.org/10.1111/1440-1681.13070DOI Listing
February 2019
2 Reads

Successful treatment of abdominal compartment syndrome with chemotherapy in a patient with a newly diagnosed Burkitt lymphoma.

J Crit Care 2019 Jan 22;51:26-28. Epub 2019 Jan 22.

Department of Anesthesiology and Operative Intensive Care Medicine, Medical Center Cologne Merheim, University of Witten/Herdecke, Germany. Electronic address:

Mortality of patients treated on the intensive care unit suffering from cancer is high, especially when admitted with an unknown malignancy. Still, anti-tumor therapy in critically ill patients requiring mechanical ventilation is a clinical challenge. Over the last years, successful chemotherapy has been reported, even in critically ill patients with infections and organ failure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08839441183165
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http://dx.doi.org/10.1016/j.jcrc.2019.01.021DOI Listing
January 2019
7 Reads

Identification of virus-encoded circular RNA.

Virology 2019 Mar 16;529:144-151. Epub 2019 Jan 16.

Department of Pathology, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:

Circular RNAs (circRNAs) are a novel class of non-coding RNA molecules in eukaryotic organisms that have potentially important roles in gene regulation. Nevertheless, whether viruses can encode circRNA is still uncertain. To examine whether large genome DNA viruses can generate circRNA during the infection of human cells, we performed RNA sequencing of ribosomal RNA-depleted total RNA from Epstein-Barr virus (EBV)-infected cell lines, including SNU-719, AGS-EBV, C666-1 and Akata. Read More

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http://dx.doi.org/10.1016/j.virol.2019.01.014DOI Listing
March 2019
1 Read

Trends in survival of patients with stage I/II Burkitt lymphoma in the United States: A SEER database analysis.

Cancer Med 2019 Jan 31. Epub 2019 Jan 31.

Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Centre of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China.

The treatment strategy for management of Burkitt lymphoma (BL) has evolved during the past decades and the clinical outcome for this disease as a whole has also improved. Due to limited information reported on survival trends of patients with stage I/II (limited-stage) BL, here we used the Surveillance, Epidemiology, and End Results (SEER) database to conduct our study. The time period was divided into two eras (1983-2001 and 2002-2014) as the recent era reflected more intensive chemotherapy regimens, the availability of rituximab, the widespread use of antiretroviral therapy (ART) and improvements in supportive care. Read More

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http://dx.doi.org/10.1002/cam4.1870DOI Listing
January 2019
1 Read

HIV-1 Tat protein induces aberrant activation of AICDA in human B-lymphocytes from peripheral blood.

J Cell Physiol 2019 Jan 31. Epub 2019 Jan 31.

Department of UMR8126, Institut Gustave Roussy, Villejuif, France.

Individuals infected with human immunodeficiency virus (HIV) are at increased risk for Burkitt lymphoma, a B-cell malignancy which occurs after a chromosomal translocation rearranging the MYC oncogene with an immunoglobulin gene locus, usually the IGH heavy chain gene locus. We have previously reported that the HIV protein Tat which circulates in all HIV-positive individuals whatever their immune status caused an increased rate of colocalization between IGH and MYC in B-cells nuclei. We here present in vitro evidence that Tat activates the expression of the AICDA gene that encodes the activation-induced cytidine deaminase whose physiological function is to create double-strand breaks for immunoglobulin gene maturation. Read More

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http://dx.doi.org/10.1002/jcp.28219DOI Listing
January 2019
2 Reads

Hematopoietic stem cell transplantation in children and adolescents with relapsed or refractory B-cell non-Hodgkin lymphoma.

Int J Hematol 2019 Jan 30. Epub 2019 Jan 30.

Department of Pediatrics, Yamagata University School of Medicine, Yamagata, Japan.

We undertook a retrospective study using the national registry data of hematopoietic stem cell transplantation (HSCT) in Japan to investigate the effect of graft source, particularly autologous or allogeneic tissue, on the treatment outcome in patients aged less than 18 years with relapsed or refractory B-cell non-Hodgkin lymphoma (B-NHL). Survival analysis was conducted on 31 autologous HSCT (auto-HSCT) and 48 allogeneic HSCT (allo-HSCT) recipients between 1990 and 2013. The 5-year survival rates were significantly lower for allo-HSCT compared to auto-HSCT recipients (32% vs. Read More

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http://dx.doi.org/10.1007/s12185-019-02608-yDOI Listing
January 2019
2 Reads

Traumatic Rupture of Jejunal Burkitt's Lymphoma with Intestinal Transection.

J Indian Assoc Pediatr Surg 2019 Jan-Mar;24(1):61-62

Department of Pediatric Surgery, Sardar Patel Medical College and Associated Group of Hospitals, Bikaner, Rajasthan, India.

Burkitt's lymphoma (BL) is an aggressive non-Hodgkin lymphoma.[1] BL of the small intestine, presenting as a surgical emergency needing emergency laparotomy, is an uncommon presentation of this tumor. We present a case of BL presenting as perforation peritonitis after blunt trauma abdomen. Read More

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http://dx.doi.org/10.4103/jiaps.JIAPS_67_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322174PMC
January 2019
1 Read

Outcome of pediatric non-Hodgkin lymphoma in Central America: A report of the Association of Pediatric Hematology Oncology of Central America (AHOPCA).

Pediatr Blood Cancer 2019 Jan 24:e27621. Epub 2019 Jan 24.

Department of Oncology, Leukemia/Lymphoma Division, and Global Pediatric Medicine Program, St. Jude Children's Research Hospital, Memphis, Tennessee.

Background: Treating B-non-Hodgkin lymphoma (B-NHL) in lower-income countries is challenging because of imprecise diagnosis, the increased risk of fatal toxicity associated with advanced disease at presentation, and limited supportive care.

Procedure: Central American patients with newly diagnosed stage I or II B-NHL received a modified Berlin-Frankfurt-Münster (BFM) regimen including a prephase (prednisone, cyclophosphamide) followed by A/B/A courses (A: cytarabine, dexamethasone, etoposide, ifosfamide, methotrexate, and intrathecal therapy; B: cyclophosphamide, dexamethasone, doxorubicin, methotrexate, and intrathecal therapy). Those with stage III or IV NHL received additional courses (B/A/B), intensified for stage IV disease by additional vincristine and methotrexate doses. Read More

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http://doi.wiley.com/10.1002/pbc.27621
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http://dx.doi.org/10.1002/pbc.27621DOI Listing
January 2019
11 Reads

Sporadic Burkitt Lymphoma with Orbital Extramedullary Infiltration.

Ocul Oncol Pathol 2019 Jan 23;5(1):46-49. Epub 2018 May 23.

Cole Eye Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

Background/aims: Sporadic Burkitt lymphoma is rarely associated with orbital involvement.

Methods: We present a case of sporadic Burkitt lymphoma with extramedullary subperiosteal leukemic infiltrates of the orbit and facial bones.

Results: Follow-up examination after chemotherapy and disease remission reveals resolution of the subperiosteal infiltrates. Read More

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https://www.karger.com/Article/FullText/488710
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http://dx.doi.org/10.1159/000488710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341329PMC
January 2019
7 Reads

Treatment outcomes of adult Burkitt lymphoma: results with a modified LMB protocol in Brazil and feasibility of outpatient administration.

J Chemother 2018 Oct - Dec;30(6-8):375-379

a Department of Hematology , Institute of Cancer of São Paulo (ICESP), University of São Paulo , São Paulo , Brazil.

While Burkitt lymphoma (BL) is an aggressive subtype of non-Hodgkin lymphoma more prevalent in tropical areas, few studies on BL have been conducted in Latin America. Here, we evaluate the clinical presentation and outcomes of an adapted LMB regimen for adults with sporadic BL. We retrospectively evaluated hospital records from University of São Paulo (USP) between 1999 and 2017. Read More

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http://dx.doi.org/10.1080/1120009X.2018.1535771DOI Listing
January 2019
2 Reads

MicroRNAs of Epstein-Barr Virus Attenuate T-Cell-Mediated Immune Control .

MBio 2019 01 15;10(1). Epub 2019 Jan 15.

Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland

The human persistent and oncogenic Epstein-Barr virus (EBV) was one of the first viruses that were described to express viral microRNAs (miRNAs). These have been proposed to modulate many host and viral functions, but their predominant role has remained unclear. We compared recombinant EBVs expressing or lacking miRNAs during infection of mice with reconstituted human immune system components and found that miRNA-deficient EBV replicates to lower viral titers with decreased frequencies of proliferating EBV-infected B cells. Read More

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http://mbio.asm.org/lookup/doi/10.1128/mBio.01941-18
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http://dx.doi.org/10.1128/mBio.01941-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336420PMC
January 2019
8 Reads

A Survival Analysis of Pediatric Tonsillar Malignancies and Review of a Rare Case.

Int J Pediatr Otorhinolaryngol 2019 Mar 28;118:160-164. Epub 2018 Dec 28.

University of Central Florida College of Medicine, Orlando, FL, USA; Division of Otolaryngology, Nemours Children's Hospital, Orlando, FL, USA. Electronic address:

Objective: To examine the survival of pediatric tonsillar cancer patients and review a rare case of pediatric tonsillar cancer.

Methods: Pediatric patients in the Surveillance, Epidemiology, and End Results (SEER) database were included from 1973 to 2014 based on a diagnosis of tonsillar malignancy using the ICD O-3 tonsil primary site codes of: C09.0, C09. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876183064
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http://dx.doi.org/10.1016/j.ijporl.2018.12.033DOI Listing
March 2019
3 Reads

Stage I non-Hodgkin lymphoma: no plateau in disease-specific survival ?

Ann Hematol 2019 Jan 8. Epub 2019 Jan 8.

Department of Haematology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.

Stage I non-Hodgkin lymphoma (NHL) is rare; prognostic impact of different histologic subtypes and treatment modality is still unclear. We used the Surveillance, Epidemiology and End Results (SEER) database to evaluate survival outcomes among adult patients (age ≥ 18 years, N = 58,230) diagnosed with stage I NHL of various histologic subtypes between 1998 and 2014. Five-year disease-specific survival of patients with stage I diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), marginal zone lymphoma (MZL), small lymphocytic lymphoma (SLL), Burkitt lymphoma (BL), mantle cell lymphoma (MCL), and peripheral T cell lymphoma (PTCL) was 82%, 92%, 95%, 89%, 78%, 77%, and 77%, respectively. Read More

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http://link.springer.com/10.1007/s00277-018-3571-7
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http://dx.doi.org/10.1007/s00277-018-3571-7DOI Listing
January 2019
10 Reads

Genome-wide discovery of somatic coding and non-coding mutations in pediatric endemic and sporadic Burkitt lymphoma.

Blood 2019 Jan 7. Epub 2019 Jan 7.

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, United States.

Though generally curable with intensive chemotherapy in resource-rich settings, Burkitt lymphoma (BL) remains a deadly disease in older patients and in sub-Saharan Africa. Epstein-Barr virus (EBV) positivity is a feature in over 90% of cases in malaria-endemic regions and up to 30% elsewhere. However, the molecular features of BL have not been comprehensively evaluated when taking into account tumor EBV status or geographic origin. Read More

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-09
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http://dx.doi.org/10.1182/blood-2018-09-871418DOI Listing
January 2019
25 Reads
10.452 Impact Factor

Mature B-NHL in children, adolescents and young adults: current therapeutic approach and emerging treatment strategies.

Br J Haematol 2019 Jan 6. Epub 2019 Jan 6.

Division of Hematology/Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.

Mature B cell lymphomas account for approximately 60% of all cases of non-Hodgkin lymphoma (NHL) in children and adolescents and includes Burkitt lymphoma (BL), diffuse large B cell lymphoma (DLBCL) and other less common histologies. The outcome for patients treated with modern regimens in resource-intensive settings is excellent. Improvements in care have been accomplished through enhanced supportive therapy, including tumour lysis management and incremental refinement of chemotherapy backbones via cooperative group clinical trials in which patients receive risk group-specific intensive chemotherapy. Read More

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http://dx.doi.org/10.1111/bjh.15734DOI Listing
January 2019
3 Reads

Clinical presentation and characteristics of lymphoma in the head and neck region.

Head Face Med 2019 Jan 3;15(1). Epub 2019 Jan 3.

Department of ENT, Head and Neck Surgery, Klinikum Rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, 81675, Munich, Germany.

Background: The study analyses clinical characteristics of histologically defined head and neck (H&N) lymphoma to raise the awareness of ENT specialists to the leading symptoms.

Method: From 2003 to 2011, all patients with histologically defined H&N lymphoma from our clinic were evaluated.

Results: This study identified 221 patients with H&N lymphoma comprising 193 non-Hodgkin lymphomas (NHL) and 28 Hodgkin lymphomas (HL). Read More

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https://head-face-med.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13005-018-0186-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317257PMC
January 2019
4 Reads
0.867 Impact Factor

Epstein-Barr virus, malaria and endemic Burkitt lymphoma.

EBioMedicine 2019 Jan 22;39:13-14. Epub 2018 Dec 22.

Institute of Tropical Medicine, Universitätsklinikum Tübingen, Tübingen, Germany; Vietnamese- German Center for Medical Research (VGCARE), Hanoi, Viet Nam; Fondation Congolaise pour la Recherche Médicale (FCRM), Brazzaville, Congo; Faculty of Medicine, Duy Tan University, Da Nang, Viet Nam. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S23523964183061
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http://dx.doi.org/10.1016/j.ebiom.2018.12.041DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355431PMC
January 2019
3 Reads