12,956 results match your criteria Burkitt Lymphoma


Modified R-CODOX-M/IVAC chemotherapy regimens in Chinese patients with untreated sporadic Burkitt lymphoma.

Cancer Biol Med 2021 Aug;18(3)

Department of Medical Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.

Objective: To characterize modified R-CODOX-M/IVAC-based chemotherapy to lower the severe adverse events in Chinese adult patients with sporadic Burkitt lymphoma.

Methods: We enrolled a retrospective cohort including 123 adult patients with untreated sporadic Burkitt lymphoma from August 2008 to September 2019 at Sun Yat-sen University Cancer Center. We studied a dose-modified and long-course R-CODOX-M/IVAC regimen utilizing a low dose of 1. Read More

View Article and Full-Text PDF

Sporadic Burkitt Lymphoma of the Thoracic and Lumbar Spinal Canal in an Adult: Oncogenicity and a Literature Review.

Cureus 2022 Jul 14;14(7):e26860. Epub 2022 Jul 14.

Department of Neurology, UMass Chan Medical School, Worcester, USA.

Burkitt lymphoma (BL) is an aggressive form of lymphoma that occurs due to translocation of the proto-oncogene on chromosome 8. BL is characterized by three distinct groups: African/endemic variant, immunosuppressive variant, or sporadic variant. Most cases of the sporadic variant occur in patients less than 40 years of age with a median age of 30 at diagnosis and are primarily seen in Caucasians. Read More

View Article and Full-Text PDF

Splenic Marginal Zone Lymphoma With Histological Transformation to Hodgkin's Lymphoma.

Cureus 2022 Jul 11;14(7):e26738. Epub 2022 Jul 11.

Hematology/Oncology, Saint Michael's Medical Center, Newark, USA.

Marginal zone lymphoma (MZL) is a rare, slow-growing/indolent B cell lymphoid neoplasm accounting for 10.5% to 11.8% of all B cell lymphomas. Read More

View Article and Full-Text PDF

[Reduced Expression of the Tissue-Specific Oct-IL Isoform Exerts an Antitumor Effect on Namalwa Burkitt's Lymphoma Cells].

Mol Biol (Mosk) 2022 Jul-Aug;56(4):595-603

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991 Russia.

Increased expression levels of the Oct-1 transcription factor is considered to be one of the key markers of poor cancer prognosis. In addition to the ubiquitous Oct-1A isoform, which is found in all cells, there also exists a tissue-specific Oct-1L isoform, which is expressed in hematopoietic cells. Oct-1L increases cell resistance to different stresses and also regulates the expression of genes controlling differentiation of hematopoietic and immune system cells. Read More

View Article and Full-Text PDF

Effect of CB2 Stimulation on Gene Expression in Pediatric B-Acute Lymphoblastic Leukemia: New Possible Targets.

Int J Mol Sci 2022 Aug 3;23(15). Epub 2022 Aug 3.

Department of Woman, Child and General and Specialist Surgery, Via Luigi De Crecchio 4, 80138 Naples, Italy.

Acute lymphoblastic leukemia type B (B-ALL) is the most common kind of pediatric leukemia, characterized by the clonal proliferation of type B lymphoid stem cells. Important progress in ALL treatments led to improvements in long-term survival; nevertheless, many adverse long-term consequences still concern the medical community. Molecular and cellular target therapies, together with immunotherapy, are promising strategies to overcome these concerns. Read More

View Article and Full-Text PDF

High expression of HIV-1 matrix protein p17 in both lymphoma and lymph node tissues of AIDS patients.

Pathol Res Pract 2022 Aug 4;237:154061. Epub 2022 Aug 4.

Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for infectious disease, State Key Discipline of Infectious Disease, The Third People's Hospital of Shenzhen, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong 518112, China.

Background: HIV-1 matrix protein p17 was found to be associated with lymphoma development in vitro. This study aimed to elucidate the pathogenetic roles of HIV-1 p17 in AIDS-related lymphoma.

Methods: Expression of HIV-1 proteins p17, p24, nef and tat were evaluated in tumor tissue samples from 60 lymphoma patients and lymph node samples from 23 non-lymphoma patients with HIV-1 infection by immunohistochemistry. Read More

View Article and Full-Text PDF

Acute kidney injury leading to the diagnosis of sporadic testicular Burkitt's lymphoma: A case report.

Int J Surg Case Rep 2022 Aug 2;97:107471. Epub 2022 Aug 2.

Department of Nephrology, Dialysis, and Transplantation, Hedi Chaker University Hospital, Sfax, Tunisia. Electronic address:

View Article and Full-Text PDF

Poor treatment responses were related to poor outcomes in pediatric B cell acute lymphoblastic leukemia with KMT2A rearrangements.

BMC Cancer 2022 Aug 6;22(1):859. Epub 2022 Aug 6.

Department of Hematology, Children's Hospital of Chongqing Medical University, Yuzhong District, Zhongshan 2nd Road, Chongqing, 400014, People's Republic of China.

Background: The KMT2A gene, formerly named the MLL gene, is rearranged (KMT2Ar) in 70-75% of infants, 5-6% of children and 10-15% of adult patients with B cell acute lymphoblastic leukemia (B-ALL). The outcome after chemotherapy of pediatric cases remains poor, and only a few studies have investigated the clinical and laboratory features, treatment response and prognosis in Chinese populations.

Methods: A total of 48 B-ALL children with KMT2Ar were enrolled in the study, and clinical and laboratory data were collected and analyzed by age group. Read More

View Article and Full-Text PDF

[Treatment strategy for B cell precursor acute lymphoblastic leukemia in children].

Authors:
Katsuyoshi Koh

Rinsho Ketsueki 2022 ;63(7):816-825

Department of Hematology/Oncology, Saitama Children's Medical Center.

Over the last 60 years, treatment outcomes for pediatric B cell precursor acute lymphoblastic leukemia have improved dramatically, resulting in long-term survival in approximately 90% of cases. These advancements are the results findings of Biological studies, their acceptance as prognostic factors for treatment responses, including MRD, and the accumulation of clinical trials including many randomized controlled trials. Further improvements in the cure rate and reduction of short-term and long-term complications will be issued in the future. Read More

View Article and Full-Text PDF

Impact of Epstein-Barr virus co-infection on natural acquired Plasmodium vivax antibody response.

PLoS Negl Trop Dis 2022 Aug 3;16(8):e0010305. Epub 2022 Aug 3.

Instituto René Rachou/FIOCRUZ Minas, Belo Horizonte, Minas Gerais, Brazil.

Background: The simultaneous infection of Plasmodium falciparum and Epstein-Barr virus (EBV) could promote the development of the aggressive endemic Burkitt's Lymphoma (eBL) in children living in P. falciparum holoendemic areas. While it is well-established that eBL is not related to other human malaria parasites, the impact of EBV infection on the generation of human malaria immunity remains largely unexplored. Read More

View Article and Full-Text PDF

Heart-lung transplantation for primary lung transplant complications.

Pediatr Transplant 2022 Aug 3:e14365. Epub 2022 Aug 3.

End-stage Lung Failure Program, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

View Article and Full-Text PDF

The Association of Epstein-Barr Virus With Cancer.

Cureus 2022 Jun 25;14(6):e26314. Epub 2022 Jun 25.

Cardiology, Omar Hospital and Cardiac Center, Lahore, PAK.

Epstein-Barr virus (EBV) is classified as a herpesvirus and is known for being one of the few viruses that can lead to the development of cancer. This study has gathered several studies to provide evidence as to this association as well as some of the mechanisms specific to EBV that allow this to happen. The development of EBV into cancer as well as the proteins involved in this oncogenesis play a crucial role in understanding this problem as well as creating a solution for mitigating this disease process in the future. Read More

View Article and Full-Text PDF

Epstein-Barr virus and Burkitt's lymphoma. Associations in Iraqi Kurdistan and twenty-two countries assessed in the International Incidence of Childhood Cancer.

Infect Agent Cancer 2022 Jul 27;17(1):39. Epub 2022 Jul 27.

Shorsh Teaching Hospital, Quirga Road, Sulaymaniyah, Iraq.

Background: Burkitt's lymphoma (BL) has worldwide variations in incidence that are related to the age of Epstein-Barr virus (EBV) infection. This study examined the age-specific incidence rate (ASIR) of BL and community EBV seropositivity in Iraqi Kurdistan and compared results with data from countries tabulated in the International Incidence of Childhood Cancer volume 3 (IICC-3).

Methods: The ASIR (95% confidence intervals) of BL in Sulaimani Governorate of Iraqi Kurdistan were calculated for the years 2010-2020. Read More

View Article and Full-Text PDF

Classifying Germinal Center Derived Lymphomas-Navigate a Complex Transcriptional Landscape.

Cancers (Basel) 2022 Jul 14;14(14). Epub 2022 Jul 14.

Interdisciplinary Centre for Bioinformatics, University Leipzig (IZBI), 04107 Leipzig, Germany.

Classification of lymphoid neoplasms is based mainly on histologic, immunologic, and (rarer) genetic features. It has been supplemented by gene expression profiling (GEP) in the last decade. Despite the considerable success, particularly in associating lymphoma subtypes with specific transcriptional programs and classifier signatures of up- or downregulated genes, competing molecular classifiers were often proposed in the literature by different groups for the same classification tasks to distinguish, e. Read More

View Article and Full-Text PDF

Whole genome sequencing and inheritance-based variant filtering as a tool for unraveling missing heritability in pediatric cancer.

Pediatr Hematol Oncol 2022 Jul 25:1-15. Epub 2022 Jul 25.

Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium.

Survival rates for pediatric cancer have significantly increased the past decades, now exceeding 70-80% for most cancer types. The cause of cancer in children and adolescents remains largely unknown and a genetic susceptibility is considered in up to 10% of the cases, but most likely this is an underestimation. Families with multiple pediatric cancer patients are rare and strongly suggestive for an underlying predisposition to cancer. Read More

View Article and Full-Text PDF

High urinary CXCL10/Cr with onset of Burkitt lymphoma in a pediatric kidney transplant recipient.

Pediatr Transplant 2022 Jul 23:e14354. Epub 2022 Jul 23.

Department of Nephrology, BC Children's Hospital, Vancouver, British Columbia, Canada.

Background: Urinary CXCL10/Cr is a promising diagnostic tool for early detection of TCMR in pediatric transplant recipients, and most studies focus on its utility in the context of localized allograft inflammation thus far. Other sources of inflammation that may be detected by CXCL10 are less clear.

Methods: We present a case review of a patient with BL, who was enrolled in a prospective trial of urinary CXCL10 monitoring. Read More

View Article and Full-Text PDF

Towards zero percent treatment abandonment of patients with common and curable childhood cancer types in Blantyre, Malawi.

Pediatr Blood Cancer 2022 Jul 23:e29899. Epub 2022 Jul 23.

Department of Paediatrics, Kamuzu University of Health Sciences, Blantyre, Malawi.

Background: Treatment abandonment is a common cause of treatment failure in low-income countries (LIC). We implemented a comprehensive package of interventions aiming to enable all families to complete the treatment of their child. The objective of this study was to evaluate the impact of those interventions. Read More

View Article and Full-Text PDF

The lncRNA KTN1-AS1 co-regulates a variety of Myc-target genes and enhances proliferation of Burkitt lymphoma cells.

Hum Mol Genet 2022 Jul 22. Epub 2022 Jul 22.

Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen (UMCG), Groningen, the Netherlands.

Long noncoding RNAs (lncRNAs) are involved in many normal and oncogenic pathways through a diverse repertoire of transcriptional and posttranscriptional regulatory mechanisms. LncRNAs that are under tight regulation of well-known oncogenic transcription factors such as c-Myc (Myc) are likely to be functionally involved in their disease-promoting mechanisms. Myc is a major driver of many subsets of B cell lymphoma and to date remains an undruggable target. Read More

View Article and Full-Text PDF

CAR T-cells in relapsed Burkitt lymphoma - a promising test drive in a rare disease.

Leuk Lymphoma 2022 Jul 20:1-2. Epub 2022 Jul 20.

Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, USA.

View Article and Full-Text PDF

Effect of Meloxicam on the Proliferation and Apoptosis of the Raji Cell Line: an In Vitro Study.

Int J Dent 2022 6;2022:9579326. Epub 2022 Jul 6.

Oral Biology Department, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia.

Meloxicam, a nonsteroidal anti-inflammatory drug, inhibits the production of PGE2 by blocking Cox-2 activity. Specific inhibition of Cox-2 can be useful in cancer therapy by apoptosis stimulation. The objective of the research was to study the effect of meloxicam on the proliferation and apoptosis of Raji cell lines. Read More

View Article and Full-Text PDF

Diffuse large B-cell lymphoma versus Burkitt lymphoma with discordant diagnostic cytogenetics: Morphology trumps.

EJHaem 2021 Nov 26;2(4):889-890. Epub 2021 Oct 26.

Department of Pathology and Laboratory Medicine University of British Columbia Vancouver Canada.

View Article and Full-Text PDF
November 2021

A case report of acquired immunodeficiency syndrome (AIDS)-related refractory Burkitt lymphoma got complete remission by multidisciplinary and multi-target combined therapy.

Transl Cancer Res 2022 Jun;11(6):1806-1812

Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Background: The incidence of Burkitt lymphoma among acquired immunodeficiency syndrome (AIDS) patients is significantly higher than that in general populations. It often features high malignancy and a poor prognosis. For patients with AIDS-related Burkitt lymphoma, the guidelines recommend the dose-adjusted EPOCH-R (DA-EPOCH-R) regimen (rituximab + etoposide vincristine + doxorubicin + cyclophosphamide + dexamethasone) as one of the first-line treatment options. Read More

View Article and Full-Text PDF

Eponyms in Malignant Hematology.

Cancer Treat Res Commun 2022 Jun 17:100594. Epub 2022 Jun 17.

Division of Hematology/Oncology, Department of Medicine, University of California, Irvine Medical Center, Orange, California, United States.

Eponyms have been traditionally used in the field of medicine to honor the contributions of an individual or group of individuals in understanding a disease. However, many eponyms have come under scrutiny given the personal backgrounds of individuals for whom they intend to honor. As we previously reviewed commonly used eponyms in medical oncology, we now aim to review commonly used eponyms in malignant hematology in order to highlight the individuals for whom they are named after. Read More

View Article and Full-Text PDF

[Extensive reduction of anti-human leukocyte antigen antibodies after chemotherapy including blinatumomab for B-cell acute lymphoblastic leukemia].

Rinsho Ketsueki 2022 ;63(6):550-554

Department of Hematology, Toranomon Hospital Kajigaya.

A 66-year-old man with fever was diagnosed with B-cell acute lymphoblastic leukemia. He failed to achieve complete remission after initial hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD) therapy and was referred to our hospital to undergo allogeneic stem cell transplantation. Bone marrow aspiration showed 97. Read More

View Article and Full-Text PDF

Venetoclax enhances the efficacy of therapeutic antibodies in B-cell malignancies by augmenting tumor cell phagocytosis.

Blood Adv 2022 07 12. Epub 2022 Jul 12.

Department of Pediatrics, Otto-von-Guericke University Magdeburg, Magdeburg Germany

Immunotherapy has evolved as a powerful tool for the treatment of B-cell malignancies and patient outcomes have improved by combining therapeutic antibodies with conventional chemotherapy. Overexpression of anti-apoptotic B-cell lymphoma 2 (Bcl-2) is associated with a poor prognosis and increased levels have been described in patients with "double-hit" diffuse large B cell lymphoma, a subgroup of Burkitt´s lymphoma and pediatric ALL patients harboring a t(17;19) translocation. Here, we show that the addition of venetoclax (VEN), a specific Bcl-2 inhibitor, potently enhanced the efficacy of the therapeutic anti-CD20 antibody rituximab (RTX), anti-CD38 daratumumab (DARA) and anti-CD19, named CD19-DE, a proprietary version of tafasitamab. Read More

View Article and Full-Text PDF

Preliminary Cytomorphologic Diagnosis of Hematolymphoid Malignancies in Effusions: A Cyto-histo Correlation with Lessons on Restraint.

J Cytol 2022 Apr-Jun;39(2):59-65. Epub 2022 May 30.

Senior Professor, Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

Background: Effusions as part of hematologic neoplasms are rare and as a primary presentation, rarer. In standalone laboratories of developing countries, resorting to techniques such as flow cytometry or immunohisto/cytochemistry may not be possible. A near definitive diagnosis on cytomorphology would, therefore, be an ideal beginning. Read More

View Article and Full-Text PDF

Formation of Lymphoma Hybrid Spheroids and Drug Testing in Real Time with the Use of Fluorescence Optical Tweezers.

Cells 2022 07 5;11(13). Epub 2022 Jul 5.

Department of Optics and Photonics, Faculty of Fundamental Problems of Technology, Wrocław University of Science and Technology, 50-370 Wrocław, Poland.

Interactions between stromal and lymphoma cells in the bone marrow are closely related to drug resistance and therapy failure. Physiologically relevant pre-clinical three-dimensional (3D) models recapitulating lymphoma microenvironmental complexity do not currently exist. In this study, we proposed a scheme for optically controlled hybrid lymphoma spheroid formation with the use of optical tweezers (OT). Read More

View Article and Full-Text PDF

Infiltration of Bilateral Optic Nerves in Burkitt Lymphoma: A Case Report.

Cureus 2022 May 31;14(5):e25515. Epub 2022 May 31.

Department of Ophthalmology and Visual Science, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, MYS.

Burkitt lymphoma (BL) is one of the highly aggressive non-Hodgkin B-cell lymphomas. The optic nerve can be affected in case of isolated lymphoma or together with the central nervous system (CNS) and systemic lymphoma. We report a rare case of involvement of bilateral optic nerves in BL. Read More

View Article and Full-Text PDF