11,908 results match your criteria Burkitt Lymphoma


MicroRNAs of Epstein-Barr Virus Attenuate T-Cell-Mediated Immune Control .

MBio 2019 Jan 15;10(1). Epub 2019 Jan 15.

Viral Immunobiology, Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland

The human persistent and oncogenic Epstein-Barr virus (EBV) was one of the first viruses that were described to express viral microRNAs (miRNAs). These have been proposed to modulate many host and viral functions, but their predominant role has remained unclear. We compared recombinant EBVs expressing or lacking miRNAs during infection of mice with reconstituted human immune system components and found that miRNA-deficient EBV replicates to lower viral titers with decreased frequencies of proliferating EBV-infected B cells. Read More

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http://dx.doi.org/10.1128/mBio.01941-18DOI Listing
January 2019

A Survival Analysis of Pediatric Tonsillar Malignancies and Review of a Rare Case.

Int J Pediatr Otorhinolaryngol 2018 Dec 28;118:160-164. Epub 2018 Dec 28.

University of Central Florida College of Medicine, Orlando, FL, USA; Division of Otolaryngology, Nemours Children's Hospital, Orlando, FL, USA. Electronic address:

Objective: To examine the survival of pediatric tonsillar cancer patients and review a rare case of pediatric tonsillar cancer.

Methods: Pediatric patients in the Surveillance, Epidemiology, and End Results (SEER) database were included from 1973 to 2014 based on a diagnosis of tonsillar malignancy using the ICD O-3 tonsil primary site codes of: C09.0, C09. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876183064
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http://dx.doi.org/10.1016/j.ijporl.2018.12.033DOI Listing
December 2018
1 Read

Stage I non-Hodgkin lymphoma: no plateau in disease-specific survival ?

Ann Hematol 2019 Jan 8. Epub 2019 Jan 8.

Department of Haematology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.

Stage I non-Hodgkin lymphoma (NHL) is rare; prognostic impact of different histologic subtypes and treatment modality is still unclear. We used the Surveillance, Epidemiology and End Results (SEER) database to evaluate survival outcomes among adult patients (age ≥ 18 years, N = 58,230) diagnosed with stage I NHL of various histologic subtypes between 1998 and 2014. Five-year disease-specific survival of patients with stage I diffuse large B cell lymphoma (DLBCL), follicular lymphoma (FL), marginal zone lymphoma (MZL), small lymphocytic lymphoma (SLL), Burkitt lymphoma (BL), mantle cell lymphoma (MCL), and peripheral T cell lymphoma (PTCL) was 82%, 92%, 95%, 89%, 78%, 77%, and 77%, respectively. Read More

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http://link.springer.com/10.1007/s00277-018-3571-7
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http://dx.doi.org/10.1007/s00277-018-3571-7DOI Listing
January 2019
3 Reads

Genome-wide discovery of somatic coding and non-coding mutations in pediatric endemic and sporadic Burkitt lymphoma.

Blood 2019 Jan 7. Epub 2019 Jan 7.

Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, United States.

Though generally curable with intensive chemotherapy in resource-rich settings, Burkitt lymphoma (BL) remains a deadly disease in older patients and in sub-Saharan Africa. Epstein-Barr virus (EBV) positivity is a feature in over 90% of cases in malaria-endemic regions and up to 30% elsewhere. However, the molecular features of BL have not been comprehensively evaluated when taking into account tumor EBV status or geographic origin. Read More

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-09
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http://dx.doi.org/10.1182/blood-2018-09-871418DOI Listing
January 2019
7 Reads
10.452 Impact Factor

Mature B-NHL in children, adolescents and young adults: current therapeutic approach and emerging treatment strategies.

Br J Haematol 2019 Jan 6. Epub 2019 Jan 6.

Division of Hematology/Oncology, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.

Mature B cell lymphomas account for approximately 60% of all cases of non-Hodgkin lymphoma (NHL) in children and adolescents and includes Burkitt lymphoma (BL), diffuse large B cell lymphoma (DLBCL) and other less common histologies. The outcome for patients treated with modern regimens in resource-intensive settings is excellent. Improvements in care have been accomplished through enhanced supportive therapy, including tumour lysis management and incremental refinement of chemotherapy backbones via cooperative group clinical trials in which patients receive risk group-specific intensive chemotherapy. Read More

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http://dx.doi.org/10.1111/bjh.15734DOI Listing
January 2019

Clinical presentation and characteristics of lymphoma in the head and neck region.

Head Face Med 2019 Jan 3;15(1). Epub 2019 Jan 3.

Department of ENT, Head and Neck Surgery, Klinikum Rechts der Isar, Technical University of Munich, Ismaninger Strasse 22, 81675, Munich, Germany.

Background: The study analyses clinical characteristics of histologically defined head and neck (H&N) lymphoma to raise the awareness of ENT specialists to the leading symptoms.

Method: From 2003 to 2011, all patients with histologically defined H&N lymphoma from our clinic were evaluated.

Results: This study identified 221 patients with H&N lymphoma comprising 193 non-Hodgkin lymphomas (NHL) and 28 Hodgkin lymphomas (HL). Read More

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https://head-face-med.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13005-018-0186-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317257PMC
January 2019
2 Reads

Epstein-Barr virus, malaria and endemic Burkitt lymphoma.

EBioMedicine 2018 Dec 21. Epub 2018 Dec 21.

Institute of Tropical Medicine, Universitätsklinikum Tübingen, Tübingen, Germany; Vietnamese- German Center for Medical Research (VGCARE), Hanoi, Viet Nam; Fondation Congolaise pour la Recherche Médicale (FCRM), Brazzaville, Congo; Faculty of Medicine, Duy Tan University, Da Nang, Viet Nam. Electronic address:

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http://dx.doi.org/10.1016/j.ebiom.2018.12.041DOI Listing
December 2018
1 Read

Carfilzomib-induced tumor lysis syndrome in relapsed multiple myeloma: a report of two cases.

Tumori 2018 Dec 23:300891618793817. Epub 2018 Dec 23.

1 Department of Hematology, Kocaeli University School of Medicine, Kocaeli, Turkey.

Background:: Tumor lysis syndrome (TLS) is a potentially fatal complication of cancer therapy characterized by severe electrolyte and metabolic abnormalities such as hyperphosphatemia, hyperkalemia, and hypocalcaemia. TLS usually occurs in aggressive hematologic malignancies such as Burkitt lymphoma and acute leukemia. TLS has rarely been observed in multiple myeloma (MM). Read More

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http://dx.doi.org/10.1177/0300891618793817DOI Listing
December 2018
1 Read

Associations between IgG reactivity to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) antigens and Burkitt lymphoma in Ghana and Uganda case-control studies.

EBioMedicine 2018 Dec 19. Epub 2018 Dec 19.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address:

Background: Endemic Burkitt lymphoma (eBL) is an aggressive childhood B-cell lymphoma linked to Plasmodium falciparum (Pf) malaria in sub-Saharan Africa. We investigated antibody reactivity to several human receptor-binding domains of the Pf erythrocyte membrane protein 1 (PfEMP1) that play a key role in malaria pathogenesis and are targets of acquired immunity to malaria.

Methods: Serum/plasma IgG antibody reactivity was measured to 22 Pf antigens, including 18 to PfEMP1 CIDR domains between cases and controls from two populations (149 eBL cases and 150 controls from Ghana and 194 eBL cases and 600 controls from Uganda). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523964183059
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http://dx.doi.org/10.1016/j.ebiom.2018.12.020DOI Listing
December 2018
3 Reads

Mechanisms of cell death induced by arginase and asparaginase in precursor B-cell lymphoblasts.

Apoptosis 2018 Dec 21. Epub 2018 Dec 21.

Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QW, UK.

Arginase has therapeutic potential as a cytotoxic agent in some cancers, but this is unclear for precursor B acute lymphoblastic leukaemia (pre-B ALL), the commonest form of childhood leukaemia. We compared arginase cytotoxicity with asparaginase, currently used in pre-B ALL treatment, and characterised the forms of cell death induced in a pre-B ALL cell line 697. Arginase and asparaginase both efficiently killed 697 cells and mature B lymphoma cell line Ramos, but neither enzyme killed normal lymphocytes. Read More

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http://dx.doi.org/10.1007/s10495-018-1506-3DOI Listing
December 2018
1 Read

Burkitt lymphoma in a patient with Kabuki syndrome carrying a novel KMT2D mutation.

Am J Med Genet A 2018 Dec 20. Epub 2018 Dec 20.

Department of Pediatric Hematology/Oncology and Cellular and Gene Therapy, Bambino Gesù Children's Hospital, Rome, Italy.

Kabuki syndrome (KS) is an extremely rare genetic disorder, mainly caused by germline mutations at specific epigenetic modifier genes, including KMT2D. Because the tumor suppressor gene KMT2D is also frequently altered in many cancer types, it has been suggested that KS may predispose to the development of cancer. However, KS being a rare disorder, few data are available on the incidence of cancer in KS patients. Read More

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http://dx.doi.org/10.1002/ajmg.a.60674DOI Listing
December 2018

The mutational landscape of Burkitt-like lymphoma with 11q aberration is distinct from that of Burkitt lymphoma.

Blood 2018 Dec 19. Epub 2018 Dec 19.

Institute of Human Genetics, Christian-Albrechts University Kiel & University Hospital Schleswig-Holstein, Kiel, Germany

The new provisional lymphoma category Burkitt-like lymphoma with 11q aberration recently described comprises cases similar to Burkitt lymphoma (BL) on morphological, immunophenotypic and gene expression level but lacking the IG-MYC translocation. They are characterized by a peculiar imbalance pattern on chromosome 11, but the landscape of mutations is not yet described. Thus, we investigated 15 MYC-negative Burkitt-like lymphoma with 11q aberration (mnBLL,11q,) cases by copy number analysis and whole exome sequencing. Read More

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http://dx.doi.org/10.1182/blood-2018-07-864025DOI Listing
December 2018

Ibrutinib significantly inhibited Bruton's tyrosine kinase (BTK) phosphorylation, proliferation and enhanced overall survival in a preclinical Burkitt lymphoma (BL) model.

Oncoimmunology 2019 11;8(1):e1512455. Epub 2018 Oct 11.

Department of Pediatrics, New York Medical College, Valhalla, NY, USA.

Pediatric and adult patients with recurrent/refractory Burkitt lymphoma (BL) continue to have poor outcomes, emphasizing the need for newer therapeutic agents. Bruton's tyrosine kinase (BTK) is activated following B-cell receptor stimulation and in part regulates normal B-cell development. Ibrutinib, a selective and irreversible BTK inhibitor, has been efficacious in chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), Waldenström's macroglobulinemia, and marginal zone lymphoma. Read More

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http://dx.doi.org/10.1080/2162402X.2018.1512455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287791PMC
October 2018
4 Reads

The treatment results in patients with lmphoma disease in the orbit.

Cesk Slov Oftalmol 2018 ;73(5-6):211-217

Introduction: Lymphoma is a malignant disease that can affect several structures of the orbit and eye adnexa. In the area of orbit the non-Hodgkins lymphoma (NHL) is typical, which may be indolent or aggressive. Indolent subtypes include MALT (mucosa-associated lymphoid tissue), follicular lymphoma (FL), lymphoplasmocytic lymphoma (LPL). Read More

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January 2018

CD38-Specific Biparatopic Heavy Chain Antibodies Display Potent Complement-Dependent Cytotoxicity Against Multiple Myeloma Cells.

Front Immunol 2018 19;9:2553. Epub 2018 Nov 19.

Institute of Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

CD38 is overexpressed by multiple myeloma cells and has emerged as a target for therapeutic antibodies. Nanobodies are soluble single domain antibody fragments derived from the VHH variable domain of heavy chain antibodies naturally occurring in camelids. We previously identified distinct llama nanobodies that recognize three non-overlapping epitopes of the extracellular domain of CD38. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262402PMC
November 2018
5 Reads

Molecular High-Grade B-Cell Lymphoma: Defining a Poor-Risk Group That Requires Different Approaches to Therapy.

J Clin Oncol 2019 Jan 3;37(3):202-212. Epub 2018 Dec 3.

1 University of Leeds, Leeds, United Kingdom.

Purpose: Biologic heterogeneity is a feature of diffuse large B-cell lymphoma (DLBCL), and the existence of a subgroup with poor prognosis and phenotypic proximity to Burkitt lymphoma is well known. Conventional cytogenetics identifies some patients with rearrangements of MYC and BCL2 and/or BCL6 (double-hit lymphomas) who are increasingly treated with more intensive chemotherapy, but a more biologically coherent and clinically useful definition of this group is required.

Patients And Methods: We defined a molecular high-grade (MHG) group by applying a gene expression-based classifier to 928 patients with DLBCL from a clinical trial that investigated the addition of bortezomib to standard rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy. Read More

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http://dx.doi.org/10.1200/JCO.18.01314DOI Listing
January 2019
2 Reads

[Diagnostic and therapeutic values of interphase fluorescence in situ hybridization in B-cell lymphomas: a clinicopathologic analysis of 604 cases].

Zhonghua Bing Li Xue Za Zhi 2018 Dec;47(12):920-925

Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.

To investigate the feasibility and value of interphase fluorescence in situ hybridization (FISH) in the pathological diagnosis, differential diagnosis and therapeutic assessment of B-cell lymphomas. The cohort included 604 cases of B-cell lymphoma which were collected at West China Hospital from May 2010 to December 2016.And all were subjected to interphase FISH using 11 break apart or fusion probes (MYC, bcl-2, bcl-6, IRF4, MYC/IgH, bcl-2/IgH, CCND1/IgH, IgH, API2/MALT1, p53/ATM, and D13S319/CEP12). Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.12.005DOI Listing
December 2018
3 Reads

[Recent advances in pediatric non-Hodgkin lymphoma. Report on a retrospective single-center cohort and review of the literature].

Magy Onkol 2018 Dec 15;62(4):204-213. Epub 2018 Oct 15.

Gyermekgyógyászati Intézet, Gyermekhematológiai-onkológiai nem önálló Tanszék, Debreceni Egyetem, Általános Orvostudományi Kar, Debrecen, Hungary.

Classification, staging and treatment response criteria of pediatric NHL have been revised. Long-term survival reaches ~90% at the expense of severe acute toxicities. The outcome of refractory and relapsed cases is poor. Read More

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December 2018
3 Reads

Cancer incidence in Northern Uganda (2013-2016).

Int J Cancer 2018 Dec 10. Epub 2018 Dec 10.

African Cancer Registry Network, Oxford, United Kingdom.

Gulu Cancer Registry was established in 2014 to assess the incidence and survival of cancer in 4 districts of the Acholi Sub-region of northern Uganda. Here we report the results of the first 4 years of registration (2013-2016) in this largely rural population of 771,514. In total there were 1627 cases of cancers registered; 644 among men (corresponding to an ASR of 106. Read More

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http://dx.doi.org/10.1002/ijc.32053DOI Listing
December 2018
1 Read

Malignancies in adults living with HIV in Asia.

J Acquir Immune Defic Syndr 2018 Nov 29. Epub 2018 Nov 29.

Taipei Veterans General Hospital, Taipei, Taiwan.

BackgroundHaematological malignancies have continued to be highly prevalent among people living with HIV (PLHIV). This study assessed the occurrence, risk factors for, and outcomes of haematological and non-haematological malignancies in PLHIV in Asia.MethodsIncidence of malignancy after cohort enrolment was evaluated. Read More

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http://dx.doi.org/10.1097/QAI.0000000000001918DOI Listing
November 2018
2 Reads
4.556 Impact Factor

Genomics of aggressive B-cell lymphoma.

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):69-74

Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Phoenix, AZ.

The growing body of genomic information collected and applied to mature aggressive B-cell lymphoma diagnosis and management has exploded over the last few years due to improved technologies with high-throughput capacity, suitable for use on routine formalin-fixed, paraffin-embedded tissue biopsies, and decreasing costs. These techniques have made evaluation of complete DNA sequences, RNA-expression patterns, translocations, copy-number alterations, loss of heterozygosity, and DNA-methylation patterns possible on a genome-wide level. This chapter will present a case of aggressive B-cell lymphoma and discuss the most important genomic abnormalities that characterize this group of entities in the recent update to the fourth edition of the World Health Organization (WHO) lymphoma classification system. Read More

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http://dx.doi.org/10.1182/asheducation-2018.1.69DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245962PMC
November 2018

Human Oncoviruses: Mucocutaneous Manifestations, Pathogenesis, Therapeutics, and Prevention (Part I: Papillomaviruses and Merkel cell polyomavirus).

J Am Acad Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Center for Clinical Studies, Houston, TX, USA; Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX, USA.

In 1964, the first human oncovirus, Epstein-Barr virus (EBV), was identified in Burkitt lymphoma cells. Since then, six other human oncoviruses have been identified: human papillomavirus (HPV), Merkel cell polyomavirus (MCPyV), hepatitis B and C viruses (HBV and HCV), human T-cell lymphotropic virus-1 (HTLV-1), and human herpesvirus-8 (HHV-8). These viruses are causally linked to 12% of all cancers, many of which have mucocutaneous manifestations. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.09.062DOI Listing
November 2018
2 Reads

Human Oncoviruses: Mucocutaneous Manifestations, Pathogenesis, Therapeutics, and Prevention (Part II: Hepatitis Viruses, Human T-cell Leukemia Viruses, Herpesviruses, and Epstein-Barr Virus).

J Am Acad Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Center for Clinical Studies, Houston, TX, USA; Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX, USA.

In 1964, the first human oncovirus, Epstein-Barr virus (EBV), was identified in Burkitt lymphoma cells. Since then, six other human oncoviruses have been identified: human papillomavirus (HPV), Merkel cell polyomavirus (MCPyV), hepatitis B and C viruses (HBV and HCV), human T-cell lymphotropic virus-1 (HTLV-1), and human herpesvirus-8 (HHV-8). These viruses are causally linked to 12% of all cancers, many of which have mucocutaneous manifestations. Read More

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http://dx.doi.org/10.1016/j.jaad.2018.10.072DOI Listing
November 2018
5 Reads

High-grade Burkitt Lymphoma Presenting as a Buttock Mass and Foot Drop.

Cureus 2018 Sep 26;10(9):e3368. Epub 2018 Sep 26.

Internal Medicine, St. Mary Mercy Hospital, Livonia, USA.

Burkitt lymphoma (BL), a highly aggressive B-cell non-Hodgkin lymphoma (NHL), usually presents in children and young adults with large extranodal masses involving jaw bones, gastrointestinal tract, and central nervous system. The three main subtypes of BL are endemic, sporadic, and immunodeficiency variant. Extranodal involvement is common in each variant of BL, although muscle tissue involvement is distinctly rare. Read More

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https://www.cureus.com/articles/15206-high-grade-burkitt-lym
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http://dx.doi.org/10.7759/cureus.3368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257518PMC
September 2018
6 Reads

Combined liver-kidney transplantation for primary hyperoxaluria type I in children: Single Center Experience.

Pediatr Transplant 2018 Nov 26:e13313. Epub 2018 Nov 26.

Pediatric Hepatology Unit, Faculty of Medicine, Department of Pediatrics, Cairo University, Cairo, Egypt.

Primary hyperoxalurias are rare inborn errors of metabolism with deficiency of hepatic enzymes that lead to excessive urinary oxalate excretion and overproduction of oxalate which is deposited in various organs. Hyperoxaluria results in serious morbid-ity, end stage kidney disease (ESKD), and mortality if left untreated. Combined liver kidney transplantation (CLKT) is recognized as a management of ESKD for children with hyperoxaluria type 1 (PH1). Read More

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http://dx.doi.org/10.1111/petr.13313DOI Listing
November 2018
2 Reads

Erdheim Chester disease in a patient with Burkitt lymphoma: a case report and review of literature.

Diagn Pathol 2018 Nov 24;13(1):94. Epub 2018 Nov 24.

Department of Pathology, The Ohio State University Wexner Medical Center, 410 W. 10th Ave, N#308, Columbus, OH, 43210, USA.

Background: Erdheim Chester disease (ECD) is a rare, non-Langerhans cell histiocytosis characterized by widespread tissue infiltration by CD68-positive, CD1a-negative foamy histiocytes. ECD can be difficult to identify, and diagnosis relies on the presence of histiocytes with certain histologic and immunophenotypic features in an appropriate clinical and radiologic setting. Clinical signs and symptoms are variable depending on which organ systems are involved. Read More

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https://diagnosticpathology.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13000-018-0772-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260675PMC
November 2018
5 Reads

Efficacy of the GMALL-B-ALL/NHL2002 Protocol in Burkitt Leukaemia/Lymphoma and Aggressive Non-Hodgkin-Lymphomas with or without CNS-Involvement.

Eur J Haematol 2018 Nov 24. Epub 2018 Nov 24.

Department of Haematology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Objectives: The GMALL-B-ALL/NHL2002 protocol is effective in Burkitt-lymphoma/leukaemia (BL). Its role in other aggressive lymphomas and in patients with simultaneous central nervous system (CNS) and peripheral involvement is unclear.

Methods: This is a retrospective outcome analysis in 76 patients with BL (n=26), B-lymphoblastic lymphoma (B-LBL; n=3), diffuse large B-cell lymphoma (DLBCL; n=31), mantle-cell lymphoma (MCL; n=6), transformed B-cell non-Hodgkin lymphomas (tB-NHL; n=7) and T-cell NHL (T-NHL; n=3) treated with the GMALL-B-ALL/NHL2002 protocol. Read More

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http://dx.doi.org/10.1111/ejh.13199DOI Listing
November 2018
11 Reads

A Cross-Sectional Population Study of Geographic, Age-Specific, and Household Risk Factors for Asymptomatic Malaria Infection in Western Kenya.

Am J Trop Med Hyg 2019 Jan;100(1):54-65

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.

The burden of () malaria in Kenya is decreasing; however, it is still one of the top 10 causes of morbidity, particularly in regions of western Kenya. Between April 2015 and June 2016, we enrolled 965 apparently healthy children aged 0-15 years in former Nyanza and Western Provinces in Kenya to characterize the demographic, geographic, and household risk factors of asymptomatic malaria as part of an epidemiologic study to investigate the risk factors for endemic Burkitt lymphoma. The children were sampled using a stratified, multistage cluster sampling survey design. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0481DOI Listing
January 2019
2 Reads
2.699 Impact Factor

IDH2 inhibition enhances proteasome inhibitor responsiveness in hematological malignancies.

Blood 2019 Jan 19;133(2):156-167. Epub 2018 Nov 19.

Department of Molecular Biotechnology and Health Sciences and.

Proteasome inhibitors (PI) are extensively used for the therapy of multiple myeloma (MM) and mantle cell lymphoma. However, patients continuously relapse or are intrinsically resistant to this class of drugs. Here, to identify targets that synergize with PI, we carried out a functional screening in MM cell lines using a short hairpin RNA library against cancer driver genes. Read More

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-05
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http://dx.doi.org/10.1182/blood-2018-05-850826DOI Listing
January 2019
11 Reads

Targeting the MYC Oncogene in Burkitt Lymphoma through HSP90 Inhibition.

Cancers (Basel) 2018 Nov 16;10(11). Epub 2018 Nov 16.

Department of Biochemistry and Molecular Biology, Augusta University, 1410 Laney-Walker Blvd., Augusta, GA 30912, USA.

Overexpression of the MYC oncogene is a key feature of many human malignancies including Burkitt lymphoma. While MYC is widely regarded to be a promising therapeutic target, a clinically effective MYC inhibitor is still elusive. Here, we report an alternative strategy, targeting MYC indirectly through inhibition of the HSP90 machinery. Read More

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http://www.mdpi.com/2072-6694/10/11/448
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http://dx.doi.org/10.3390/cancers10110448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266960PMC
November 2018
12 Reads

Apatinib exerts anti-tumor activity to non-Hodgkin lymphoma by inhibition of the Ras pathway.

Eur J Pharmacol 2019 Jan 10;843:145-153. Epub 2018 Nov 10.

Department of Hematology, The First Affiliated Hospital of Xiamen University and Institute of Hematology, Medical College of Xiamen University, Xiamen, Fujian 361003, China. Electronic address:

Apatinib is a tyrosine kinase inhibitor that selectively targets vascular endothelial growth factor receptor-2 (VEGFR-2). Although apatinib has shown promising anti-tumor activity against several types of tumor, its role and underlying mechanism against non-Hodgkin lymphoma (NHL) remain to be explored. Here, we report that apatinib dramatically inhibited in vitro the proliferation of various human NHL cell lines, including Burkitt lymphoma (BL), mantle cell lymphoma (MCL), and diffuse large B-cell lymphoma (DLBCL), in a dose-dependent manner. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00142999183066
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http://dx.doi.org/10.1016/j.ejphar.2018.11.012DOI Listing
January 2019
5 Reads

miR-150 might inhibit cell proliferation and promote cell apoptosis by targeting LMO4 in Burkitt lymphoma.

J Cell Physiol 2018 Nov 13. Epub 2018 Nov 13.

Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

This study aimed at investigating the effect of microRNA-150 (miR-150) on cell proliferation of Burkitt lymphoma and its molecular mechanism. Gene expression analysis was applied to identify target genes of miR-150 in Burkitt lymphoma cell line ST486 based on the dataset from the Gene Expression Omnibus (GEO) datasets GSE86432. miRNA mimics, inhibitor and small interfering RNA (siRNA) were fluorescently labeled by Cy3, whereas plasmid vector was labeled by EGFP. Read More

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http://doi.wiley.com/10.1002/jcp.27652
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http://dx.doi.org/10.1002/jcp.27652DOI Listing
November 2018
8 Reads

Two cases of numb chin syndrome diagnosed as malignant disease.

Oxf Med Case Reports 2018 Dec 5;2018(12):omy097. Epub 2018 Nov 5.

Department of Community, Family, and General Medicine, Kumamoto University Hospital, Kumamoto 860-8556, Japan.

Numb chin syndrome (NCS) is defined as reduced or absent sensation in an area of the chin and lower lip within the distribution of the mental or inferior alveolar nerves. The causes of NCS may be neoplastic, traumatic, dental, toxic, drug-induced, inflammatory, autoimmune or infectious. NCS may be the preliminary symptom of malignancy or recurrence/metastasis in patients with cancer. Read More

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https://academic.oup.com/omcr/article/doi/10.1093/omcr/omy09
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http://dx.doi.org/10.1093/omcr/omy097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217713PMC
December 2018
6 Reads

[Clinicopathological features and treatment outcome of 37 cases of primary thyroid lymphoma].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Oct;32(20):1551-1556

Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology.

The aim of this study is to explore the clinicopathological features and treatment outcome of primary thyroid lymphoma(PTL). Clinicopathological data of 37 cases of PTL were retrospectively reviewed, and analyzed in combined with followup data. Of the 37 patients, Hashimoto's disease was diagnosed in 28(75. Read More

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http://www.cnki.net/kcms/doi/10.13201/j.issn.1001-1781.2018.
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http://dx.doi.org/10.13201/j.issn.1001-1781.2018.20.005DOI Listing
October 2018
6 Reads

A fatal back pain: report of two cases of diffuse large B cell/Burkitt-like nervous system lymphoma.

Neurol Sci 2018 Nov 1. Epub 2018 Nov 1.

Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Crkvena 20, 31 000, Osijek, Croatia.

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http://link.springer.com/10.1007/s10072-018-3631-8
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http://dx.doi.org/10.1007/s10072-018-3631-8DOI Listing
November 2018
5 Reads

Distribution of lymphomas in Turkey: data of 4239 cases from a single institution using the WHO classification

Turk J Med Sci 2018 Oct 31;48(5):1013-1023. Epub 2018 Oct 31.

Background/aim: Lymphoma cases diagnosed at one of the largest tertiary reference centers in Turkey were reviewed and findings were compared to those reported from other regions of the world. Materials and methods: Lymphomas diagnosed between 2000 and 2017 in the pathology laboratory of Hacettepe University were identified. A total of 4239 cases were analyzed. Read More

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http://dx.doi.org/10.3906/sag-1804-107DOI Listing
October 2018
1 Read

Aggressive B cell lymphomas in the 2017 revised WHO classification of tumors of hematopoietic and lymphoid tissues.

Ann Diagn Pathol 2018 Oct 2;38:6-10. Epub 2018 Oct 2.

Neogenomics, Aliso Viejo, CA, United States of America; M.D. Anderson Cancer Center, University of Texas, Department of Hematopathology, Houston, TX, United States of America. Electronic address:

The recent 2017 update of the World Health Organization classification of lymphomas has significant changes from the previous edition. Subtypes of large B cell lymphoma and related aggressive B cell lymphomas are addressed. Clinicopathological features of entities as related to morphology, immunophenotype, cell of origin, and molecular/genetic findings are reviewed with emphasis on changes or updates in findings. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183028
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http://dx.doi.org/10.1016/j.anndiagpath.2018.09.014DOI Listing
October 2018
12 Reads

Two-Step Co-Immunoprecipitation (TIP).

Curr Protoc Mol Biol 2019 Jan 30;125(1):e80. Epub 2018 Oct 30.

Institute of General Pathology, Università Cattolica del Sacro Cuore, Rome, Italy.

In the past few decades, numerous approaches have been developed to investigate protein-protein and protein-nucleic acid interactions (PPIs and PNIs). Affinity purification methods such as co-immunoprecipitation (co-IP) are commonly used to detect and isolate the macromolecular complexesresulting from these interactions. In this article, we describe a two-step co-immunoprecipitation (TIP) technique. Read More

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http://doi.wiley.com/10.1002/cpmb.80
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http://dx.doi.org/10.1002/cpmb.80DOI Listing
January 2019
2 Reads

Multiple cranial nerve palsies in immunodeficiency subtype of Burkitt lymphoma.

J Community Hosp Intern Med Perspect 2018 15;8(5):303-306. Epub 2018 Oct 15.

Department of Hematology and Oncology, Saint Agnes Hospital, Baltimore, MD, USA.

Burkitt lymphoma is a late complication of HIV, and bilateral cranial nerve palsies are extremely rare in patients with AIDS. A twenty year old Caucasian male with known congenital HIV who had been non-adherent with anti-retroviral therapy presented with multiple cranial nerve palsies and was eventually diagnosed with Burkitt lymphoma. Before chemotherapy, he was started on radiation therapy to the brain, meninges, and base of skull with the intent of improving cranial nerve palsies and preventing further neurological sequelae since the cranial nerve palsies were dense and there was concern that intrathecal chemotherapy would have less penetration than radiation. Read More

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http://dx.doi.org/10.1080/20009666.2018.1514944DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6197034PMC
October 2018

Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells.

Blood 2018 Dec 17;132(25):2670-2683. Epub 2018 Oct 17.

Immune Regulation and Cancer, Max Delbrück Center for Molecular Medicine in the Helmholtz Alliance, Berlin-Buch, Germany.

Forkhead box class O1 (FOXO1) acts as a tumor suppressor in solid tumors. The oncogenic phosphoinositide-3-kinase (PI3K) pathway suppresses FOXO1 transcriptional activity by enforcing its nuclear exclusion upon AKT-mediated phosphorylation. We show here abundant nuclear expression of FOXO1 in Burkitt lymphoma (BL), a germinal center (GC) B-cell-derived lymphoma whose pathogenesis is linked to PI3K activation. Read More

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-06
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http://dx.doi.org/10.1182/blood-2018-06-856203DOI Listing
December 2018
6 Reads

[Clinicopathologic features of breast lymphoma in core needle biopsy].

Zhonghua Bing Li Xue Za Zhi 2018 Oct;47(10):737-742

Department of Pathology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.

To investigate the clinicopathologic features and differential diagnosis of breast lymphoma in core needle biopsy. Seventy-two cases of breast lymphoma in core needle biopsy between 2011 and 2016 were extracted from the pathology database of Fudan University Shanghai Cancer Center. The clinicopathologic features were analyzed. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2018.10.001DOI Listing
October 2018
10 Reads

Ki-67 expression in mature B-cell neoplasms: a flow cytometry study.

Rev Assoc Med Bras (1992) 2018 Jun;64(6):525-529

Programa de Pós Graduação em Medicina: Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.

Objective: Ki-67 is a nuclear protein associated with cellular proliferation in normal or leukemic conditions that can help identify more aggressive diseases and is usually evaluated with immunohistochemistry. The aim of this was to assess Ki-67 expression on mature B-cell neoplasms samples with flow cytometry immunophenotyping.

Method: After surface staining with CD19 and CD45, intracellular staining for Ki-67 was performed in leukemic mature B-cells. Read More

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http://dx.doi.org/10.1590/1806-9282.64.06.525DOI Listing
June 2018
8 Reads

Burkitt Lymphoma Presenting With Intracardiac Mass and Tumor Thrombosis in the Anterior Mediastinum With Literature Review.

J Pediatr Hematol Oncol 2018 Oct 5. Epub 2018 Oct 5.

Pathology, Ankara Child Health and Diseases Hematology Oncology Training and Research Hospital.

Burkitt lymphoma manifesting as an intracardiac mass is a rare entity. This report describes the case of a 10-year-old boy who presented with an intracardiac mass and tumor thrombosis in the anterior mediastinum that proved to be Burkitt lymphoma. The LMB-96 chemotherapy protocol was given and at the end of the treatment there was still residual mass. Read More

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http://Insights.ovid.com/crossref?an=00043426-900000000-9774
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http://dx.doi.org/10.1097/MPH.0000000000001327DOI Listing
October 2018
3 Reads

Pediatric oral Epstein-Barr virus associated self-remitting CD30+ lymphoproliferative disorder: A distinct entity.

Ann Diagn Pathol 2018 Dec 12;37:57-61. Epub 2018 Sep 12.

Weill Cornell Medicine, 1300 York Ave, New York, NY 10065, USA. Electronic address:

Epstein-Barr virus (EBV) has a well-known association with lymphoproliferative disorders of B and T cell origin. EBV-related B cell lymphoproliferative disorders include Hodgkin and Burkitt lymphomas, lymphomatoid granulomatosis, EBV positive diffuse large cell B cell lymphoma of the elderly, as well as B cell lymphomas associated with solid organ transplantation and methotrexate use. EBV-related T cell disorders are primarily represented by NK/T- cell lymphoma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10929134183023
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http://dx.doi.org/10.1016/j.anndiagpath.2018.08.004DOI Listing
December 2018
5 Reads

Does it take three to tango? An unsuspected multimorbidity of CD8 T cell lymphoproliferative disorder, malaria, and EBV infection.

Malar J 2018 Oct 5;17(1):349. Epub 2018 Oct 5.

Laboratory of Malaria Immunology, Immunology Frontier Research Center (IFReC), Osaka University, Osaka, Japan.

Background: Malaria is known to cause acute and deadly complications. However, malaria can cause unforeseen pathologies due to its chronicity. It increases the risk of endemic Burkitt Lymphoma development by inducing DNA damage in germinal centre (GC) B cells, and leading higher frequency of Epstein-Barr virus (EBV)-infected cells in GCs. Read More

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http://dx.doi.org/10.1186/s12936-018-2497-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6173833PMC
October 2018
4 Reads

Burkitt lymphoma of the ovaries mimicking sepsis: a case report and review of the literature.

J Med Case Rep 2018 Oct 5;12(1):285. Epub 2018 Oct 5.

Intensive Care Unit, Tzaneio General Hospital of Piraeus, Dodonis 26, 13451, Kamatero, Greece.

Background: It is not unusual for systemic diseases to mimic sepsis and, in any case, the clinician should thoroughly investigate this possibility.

Case Presentation: We present the case of a 21-year-old Greek woman who presented to the Intensive Care Unit of our hospital with severe septic shock - multiple organ failure as a result of a suspected gynecological infection of the ovaries. An immediate improvement of her clinical condition in combination with strong clinical suspicion and negative cultures led to the differential diagnosis of diseases other than sepsis. Read More

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http://dx.doi.org/10.1186/s13256-018-1828-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6172811PMC
October 2018
3 Reads

IG- neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas.

Blood 2018 Nov 3;132(21):2280-2285. Epub 2018 Oct 3.

Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.

The notes instances of Burkitt lymphoma/leukemia (BL) with IG- rearrangement displaying a B-cell precursor immunophenotype (termed herein "preBLL"). To characterize the molecular pathogenesis of preBLL, we investigated 13 preBLL cases (including 1 cell line), of which 12 were analyzable using genome, exome, and targeted sequencing, imbalance mapping, and DNA methylation profiling. In 5 patients with reads across the IG- breakpoint junctions, we found evidence that the translocation derived from an aberrant VDJ recombination, as is typical for IG translocations arising in B-cell precursors. Read More

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http://dx.doi.org/10.1182/blood-2018-03-842088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251006PMC
November 2018
15 Reads