12,624 results match your criteria Burkitt Lymphoma

An unusual case of paediatric plasmablastic lymphoma presenting with malignant effusion and the challenges in its diagnosis.

Diagn Cytopathol 2021 Jul 23. Epub 2021 Jul 23.

Department of Pathology, Tata Memorial Hospital, Mumbai, India.

Plasmablastic lymphoma (PBL) is an aggressive non-Hodgkin lymphoma occurring commonly in the oral mucosa and jaw of human immunodeficiency virus (HIV) positive adult males. PBL is not a common occurrence in children and a presentation with malignant effusion is rarely reported. Herein, we share our experience in the challenges confronted in the diagnosis of PBL in a 6-year-old, HIV positive boy presenting with malignant pleural and peritoneal effusions along with gum hypertrophy, lymphadenopathy and paranasal sinus mass. Read More

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Mandibular sporadic Burkitt lymphoma in an adult patient: A case report and review of the literature.

Clin Case Rep 2021 Jul 21;9(7):e04535. Epub 2021 Jul 21.

Department of Oral and Maxillofacial Pathology School of Dentistry Tehran University of Medical Sciences Tehran Iran.

Only a minor percent of lymphomas arise in the oral cavity. Although rare, dentists and clinicians should not neglect them as a possible consideration in the differential diagnosis of oral lesions. Read More

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Update on Pediatric and Young Adult Mature Lymphomas.

Clin Lab Med 2021 Sep 1;41(3):359-387. Epub 2021 Jul 1.

Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, 4650 Sunset Boulevard, Mailstop #32, Los Angeles, CA 90027, USA.

After acute leukemia and brain and central nervous system tumors, mature lymphomas represent the third most common cancer in pediatric patients. Non-Hodgkin lymphoma accounts for approximately 60% of lymphoma diagnoses in children, with the remainder representing Hodgkin lymphoma. Among non-Hodgkin lymphomas in pediatric patients, aggressive lymphomas, such as Burkitt lymphoma, diffuse large B-cell lymphoma, and anaplastic large cell lymphoma, predominate. Read More

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September 2021

Combination Therapy With Anti-PD-1 or PD-1 Antibody Alone in Asian Pediatric Patients With Relapsed or Refractory Cancer.

Front Immunol 2021 6;12:647733. Epub 2021 Jul 6.

Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

There is limited experience of PD-1 antibody combined with other therapies in children. We aimed to explore the antitumor activity and safety of PD-1 antibody monotherapy or combination with other regimens in relapsed or refractory pediatric cancer. This is a retrospective-case study conducted in two Chinese expert centers. Read More

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HIV-associated Burkitt lymphoma: outcomes from a US-UK collaborative analysis.

Blood Adv 2021 07;5(14):2852-2862

Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL.

Data addressing prognostication in patients with HIV related Burkitt lymphoma (HIV-BL) currently treated remain scarce. We present an international analysis of 249 (United States: 140; United Kingdom: 109) patients with HIV-BL treated from 2008 to 2019 aiming to identify prognostic factors and outcomes. With a median follow up of 4. Read More

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HIV-1 Transactivator of Transcription (Tat) Co-operates With AP-1 Factors to Enhance Transcription.

Front Cell Dev Biol 2021 30;9:693706. Epub 2021 Jun 30.

Division of Haematology, Department of Pathology, University of Cape Town, Cape Town, South Africa.

HIV-1 infection often leads to the development of co-morbidities including cancer. Burkitt lymphoma (BL) is one of the most over-represented non-Hodgkin lymphoma among HIV-infected individuals, and displays a highly aggressive phenotype in this population group, with comparatively poorer outcomes, despite these patients being on anti-retroviral therapy. Accumulating evidence indicates that the molecular pathogenesis of HIV-associated malignancies is unique, with components of the virus playing an active role in driving oncogenesis, and in order to improve patient prognosis and treatment, a better understanding of disease pathobiology and progression is needed. Read More

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Late recurrence of Burkitt's lymphoma in the jaw: numb chin syndrome as the only symptom.

Autops Case Rep 2021 8;11:e2020218. Epub 2020 Dec 8.

Hospital Sírio-Libanês, Serviço de Medicina Bucal, São Paulo, SP, Brasil.

The Numb Chin Syndrome (NCS) is defined as facial and oral numbness restricted to the mental nerve's distribution involving the lower lip, skin of the chin, or gingiva of the lower anterior teeth. Hypoesthesia can occur unilaterally or bilaterally. Although this syndrome is rare, its importance is related to the fact that it represents the clinical manifestations of malignant diseases. Read More

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December 2020

Clinicopathologic characteristics of Burkitt lymphoma of the head and neck in a non-endemic region-a Danish nationwide study.

Acta Otolaryngol 2021 Jul 18:1-8. Epub 2021 Jul 18.

Department of Otorhinolaryngology, Head and Neck Surgery, and Audiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Background: Burkitt lymphoma rarely presents in head and neck (H&N) in Western countries.

Aims/objectives: We aimed to characterise clinicopathological features of H&N Burkitt lymphoma in Denmark representing a non-endemic region.

Material And Methods: Clinical records were reviewed for a nationwide cohort of patients diagnosed with H&N Burkitt lymphoma in Denmark between 1980 and 2018. Read More

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Level of Scientific Evidence Underlying the National Comprehensive Cancer Network Clinical Practice Guidelines for Hematologic Malignancies: Are We Moving Forward?

Oncology (Williston Park) 2021 Jul 16;35(7):390-396. Epub 2021 Jul 16.

Department of Internal Medicine, University of Minnesota Medical Center, Minneapolis, MN.

Background: The level of scientific evidence in National Comprehensive Cancer Network (NCCN) guidelines for malignant hematological conditions haven't been recently investigated. We describe the distribution of categories of evidence and consensus (EC) among the 10 most common hematologic malignancies with regard to recommendations for staging, initial and salvage therapy, and surveillance. Methods: We reviewed the level of evidence for the 10 most common hematological malignancies by incidence in the United States as of 2020. Read More

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assessment of the efficiency of the PIM-1 kinase pharmacological inhibitor as a potential treatment for Burkitt's lymphoma.

Oncol Lett 2021 Aug 29;22(2):622. Epub 2021 Jun 29.

Cell and Gene Therapy Group, Medical Genomics Research Department, King Abdullah International Medical Research Center, Ministry of National Guard-Health Affairs, Riyadh 11481, Saudi Arabia.

Burkitt's lymphoma is an aggressive form of lymphoma affecting B lymphocytes. It occurs endemically in Africa and sporadically in the rest of the world. Due to the high proliferation rate of this tumor, intensive multi-drug treatment is required; however, the risk of tumor syndrome lysis is high. Read More

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[Human immunodeficiency virus and lymphoma].

Bull Cancer 2021 Jul 7. Epub 2021 Jul 7.

CHU Mohamed VI, Université Cadi Ayyad, Faculté de Médecine, Service d'Hématologie Clinique, Marrakech, Maroc.

Lymphomas remain a leading cause of morbidity and mortality for HIV-positive patients. The most common lymphomas include diffuse large B-cell lymphoma, Burkitt lymphoma, primary effusion lymphoma, plasmablastic lymphoma and Hodgkin lymphoma. Appropriate approach is determined by lymphoma stage, performans status, comorbidities, histological subtype, status of the HIV disease and immunosuppression. Read More

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Early death and treatment-related mortality: A report from SUCCOUR - Supportive Care for Children with Cancer in Africa.

Pediatr Blood Cancer 2021 Sep 10;68(9):e29230. Epub 2021 Jul 10.

Queen Elizabeth Central Hospital (QECH), College of Medicine, Blantyre, Malawi.

Background: Deaths during paediatric cancer treatment are common in Africa. It is often difficult to distinguish between treatment-related and disease-related causes. To prevent these deaths, it is important to study them and identify the cause. Read More

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September 2021

Fever and neutropenia outcomes and areas for intervention: A report from SUCCOUR - Supportive Care for Children with Cancer in Africa.

Pediatr Blood Cancer 2021 Sep 10;68(9):e29224. Epub 2021 Jul 10.

Queen Elizabeth Central Hospital (QECH), College of Medicine, Blantyre, Malawi.

Background: Death during paediatric cancer treatment is common in sub-Saharan Africa. Using the infrastructure of Supportive Care for Children with Cancer in Africa (SUCCOUR), our objective was to describe fever and neutropenia (FN) characteristics and outcomes in order to identify potential areas for future intervention.

Methods: A multicentre prospective, observational cohort study was conducted in sub-Saharan Africa. Read More

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September 2021

Identification of KMT2A-ARHGEF12 fusion in a child with a high-grade B-cell lymphoma.

Cancer Genet 2021 Jun 27;258-259:23-26. Epub 2021 Jun 27.

ARUP Laboratories, Salt Lake City, UT, United States; Department of Pathology, University of Utah, Salt Lake City, UT, United States. Electronic address:

Rearrangements involving KMT2A are common in de novo and therapy-related acute myeloid and lymphoblastic leukemias. There is a diverse recombinome associated with KMT2A involving at least 135 partner genes, with more being discovered due to advances in molecular genetic diagnostics. KMT2A-ARHGEF12 fusion has only rarely been reported, in five cases of acute leukemia and a single case of high-grade B-cell lymphoma. Read More

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CYB561A3 is the Key Lysosomal Iron Reductase Required for Burkitt B-cell Growth and Survival.

Blood 2021 Jul 7. Epub 2021 Jul 7.

Broad Institute of Harvard And MIT, United States.

Epstein-Barr virus (EBV) causes endemic Burkitt lymphoma, the leading childhood cancer in sub-Saharan Africa. Burkitt cells retain aspects of germinal center B-cell physiology with MYC-driven B-cell hyperproliferation, yet little is presently known about their iron metabolism. CRISPR/Cas9 analysis highlighted the little studied ferrireductase CYB561A3 as critical for Burkitt proliferation, but not for that of closely related EBV-transformed lymphoblastoid cells or nearly all other Cancer Dependency Map cell lines. Read More

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Burkitt Lymphoma Presenting as Perforated Appendicitis.

Am Surg 2021 Jul 4:31348211029854. Epub 2021 Jul 4.

Department of Surgery, 8083University of MississippiMedical Center, Jackson, MS, USA.

Appendicitis is the most common indication for an emergent abdominal operation in the pediatric population. Fewer than .015% of patients who undergo appendectomy for presumed appendicitis are diagnosed with primary lymphoma after evaluation of pathology specimen. Read More

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A metal-free salalen ligand with anti-tumor and synergistic activity in resistant leukemia and solid tumor cells via mitochondrial pathway.

J Cancer Res Clin Oncol 2021 Sep 2;147(9):2591-2607. Epub 2021 Jul 2.

Department of Pediatric Hematology/Oncology, Municipal Clinics of Cologne, Children's Hospital of the City Cologne, Amsterdamer Straße 59, 50735, Cologne, Germany.

Purpose: Since the discovery of the well-known cis-platin, transition metal complexes are highly recognized as cytostatic agents. However, toxic side effects of the metal ions present in the complexes may pose significant problems for their future development. Therefore, we investigated the metal-free salalen ligand WQF 044. Read More

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September 2021

Prognostic Factors, Survival Analyses and the Risk of Second Primary Cancer: A Population-Based Study on Burkitt Lymphoma/Leukemia.

Diseases 2021 Jun 15;9(2). Epub 2021 Jun 15.

Pharmaceutical Sciences Postgraduate Program, Federal University of Paraná, Curitiba 80210-170, PR, Brazil.

Burkitt lymphoma/leukemia (BL/L) is an aggressive oncohematological disease. This study evaluated the population-based prognosis and survival on BL/L as well as if BL/L behaved as a risk factor for the development of second primary cancers (SPCs) and if other first tumors behaved as risk factors for the occurrence of BL/L as an SPC. A retrospective cohort using the Surveillance, Epidemiology and End Results (SEER) Program (2008-2016) was performed. Read More

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A rare case of bilateral primary renal Burkitt lymphoma presenting with acute renal failure.

Radiol Case Rep 2021 Aug 20;16(8):2311-2314. Epub 2021 Jun 20.

Department of Radiology, Hanoi Medical University, Ha Noi, Viet Nam.

Acute renal failure due to primary renal Burkitt lymphoma in children is extremely rare. We report a case with acute secondary renal failure in a 4-year-old boy who presented with abdominal pain, anorexia, and vomiting. Abdominal computed tomography scans showed bilateral nephromegaly with multiple hypoenhancing regions. Read More

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Outcomes of Burkitt lymphoma with bone marrow involvement or Burkitt leukemia in Chinese children.

Pediatr Investig 2021 Jun 18;5(2):112-117. Epub 2021 Jun 18.

Collaborative Innovation Center for Cancer Medicine State Key Laboratory of Oncology in South China Guangzhou Guangdong China.

Importance: Burkitt lymphoma with bone marrow involvement and Burkitt leukemia behave aggressively. Thus far, there are limited data concerning survival and toxicity in Chinese children with Burkitt lymphoma or Burkitt leukemia who have undergone treatment with the non-Hodgkin's lymphoma Berlin-Frankfurt-Münster-90/95 (NHL-BFM-90/95) protocol.

Objective: To analyze outcomes and toxicity in pediatric patients who exhibit Burkitt lymphoma with bone marrow involvement or Burkitt leukemia following treatment with the NHL-BFM-90/95 protocol. Read More

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Trends in pediatric lymphoma incidence by global region, age and sex from 1988-2012.

Cancer Epidemiol 2021 Aug 23;73:101965. Epub 2021 Jun 23.

Division of Epidemiology & Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States; Masonic Cancer Center, University of Minnesota, Minneapolis, MN, United States. Electronic address:

Background: Global variation in lymphoma incidence by type and age at diagnosis, region, sex, and Human Development Index (HDI) categories has not been reported, may shed light on potential biologic mechanisms and identify areas for targeted interventions.

Methods: Using the Cancer Incidence in Five Continents data from 1988 to 2012, we identified Hodgkin (HL), non-Hodgkin (NHL), and Burkitt lymphoma (BL) diagnosed in children aged 0-19 years. We estimated incidence rates (IRs; cases/million) and average annual percent change in incidence (AAPC; 95 % CI) by geographic region, sex, and HDI for each age group (0-9years and 10-19 years). Read More

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Intracardiac EUS-B-Guided FNA for Diagnosing Cardiac Tumors.

Respiration 2021 Jun 24:1-5. Epub 2021 Jun 24.

Department of Respiratory Medicine, Location Academic Medical Center (AMC), Amsterdam University Medical Centers, Amsterdam, The Netherlands.

Primary cardiac tumors are extremely rare. Obtaining a tissue diagnosis is difficult and commonly requires open-heart surgery with associated morbidity. Esophageal endoscopic ultrasound (EUS) and EUS with the EBUS scope (EUS-B) provide real-time sampling of centrally located lung tumors and mediastinal lymph nodes. Read More

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Value of baseline and end of chemotherapy F-FDG PET/CT in pediatric patients with Burkitt lymphoma.

Leuk Lymphoma 2021 Jun 24:1-9. Epub 2021 Jun 24.

Department of Nuclear Medicine, Sun Yat-sen University Cancer Canter, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.

The aim of this study was to analyze whether the baseline metabolic parameters of F-FDG PET/CT in pediatric patients with Burkitt lymphoma (BL) can predict treatment response and prognosis. We retrospectively analyzed 68 pediatric patients with BL who underwent PET/CT before treatment. PET images were analyzed semi-quantitatively by measuring the maximum standardized uptake (SUVmax), total metabolic tumor volume (tMTV), and total lesion glycolysis (TLG). Read More

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Molecular characterization of Burkitt lymphoma in the breast or ovary.

Leuk Lymphoma 2021 Jun 24:1-10. Epub 2021 Jun 24.

Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.

Breast and ovary have been described as rare but typical sites of presentation of Burkitt lymphoma (BL) in females, particularly after puberty. We revised a historic series of 44 lymphomas of the breast or the ovary in women diagnosed between 1973 and 2014 as BL. Fluorescence hybridization (FISH) was applied to all, and array-based copy number analysis as well as expression profiling to a subset of those cases. Read More

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Ileal inflammatory pseudotumor in adolescent male patient with prior Burkitt lymphoma: A challenging diagnosis.

Radiol Case Rep 2021 Aug 8;16(8):2047-2052. Epub 2021 Jun 8.

Department of Advanced Biomedical Sciences, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy.

Inflammatory pseudotumor is a rare benign mesenchymal pediatric neoplasm, that can mimic tumoral residue or relapse at metabolic imaging with nonspecific clinical presentation and difficult diagnosis. We present the case of a 14year old male patient with fever of unknown origin and large ileal mass, diagnosed with and treated for Burkitt lymphoma, who performed several 18-fluoro-deoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) scans, during and after first line chemotherapy, showing persistent and focal uptake, while ileal mass volume decreased dramatically and the patient was clinically asymptomatic. Histopathological analysis of residual ileal mass was suggestive for xanthomatous pseudotumor, a type of inflammatory pseudotumor. Read More

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Incidence and spectrum of infections among HIV/AIDS patients with lymphoma during chemotherapy.

J Infect Chemother 2021 Jun 19. Epub 2021 Jun 19.

Fudan University (Shanghai Public Health Clinical Center), 130 Dongan Road, Xuhui District, Shanghai 200032, China; Department of Infection and Immunity, Shanghai Public Health Clinical Center, Fudan University, 2901 Caolang Road, Jinshan District, Shanghai 201508, China. Electronic address:

Introduction Lymphoma is the most common cancer in HIV/AIDS patients. Chemotherapy regiments recommended for lymphomas in HIV-negative patients are also used for lymphomas in HIV/AIDS patients. Little is known about the infections among HIV/AIDS patients with lymphoma undergoing chemotherapy. Read More

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Posttransplant Lymphoproliferative Disorder After Solid Organ Transplant: A Heterogeneous, Aggressive Disorder.

Clin Lymphoma Myeloma Leuk 2021 May 24. Epub 2021 May 24.

Department of Haematology, St Vincent's University Hospital, Elm Park, Dublin, Ireland.

Posttransplant lymphoproliferative disorder (PTLD) is a rare complication of solid organ transplant. We identified 40 patients diagnosed with PTLD between 2009 and 2020 and analyzed their presentation, treatment strategies, and outcomes. Median age at diagnosis was 52. Read More

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