5 results match your criteria Bunseki Kagaku[Journal]

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Total synthesis of the antibiotic kendomycin: a macrocyclization using the Tsuji-Trost etherification.

Angew Chem Int Ed Engl 2014 Apr 12;53(16):4213-6. Epub 2014 Mar 12.

Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Sendai 980-8577 (Japan) http://www.agri.tohoku.ac.jp/bunseki/index-j.html; Current address: Department of Materials Science, Faculty of Engineering, Shizuoka University, Shizuoka 432-8561 (Japan).

A highly stereocontrolled, convergent total synthesis of kendomycin [(-)-TAN2162], an ansa-macrocyclic antibiotic, is reported. The key of the strategy is an unprecedented Tsuji-Trost macrocyclic etherification, followed by a transannular Claisen rearrangement to construct the 18-membered carbocyclic framework. The oxa-six- and five-membered rings were also stereoselectively constructed respectively by a cascade oxidative cyclization at an unfunctionalized benzylic position and using a one-pot epoxidation/5-exo-tet epoxide opening. Read More

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http://doi.wiley.com/10.1002/anie.201400305
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http://dx.doi.org/10.1002/anie.201400305DOI Listing
April 2014
7 Reads

Alternative plugs flow liquid chromatography (APFLC)/EI-MS system using a T-shaped flow path.

Anal Sci 2011 ;27(1):95-9

Infra-red Spectroscopy Analytical Laboratory, 3-3-13 Chuo, Ebina, Kanagawa 243-0432, Japan.

The vapor condensation method can be used for forming an alternative flow of liquid masses using a single solvent for alternative plugs flow liquid chromatography (APFLC), described in our previous paper. APFLC is more effective when adopting a T-shaped flow path and aqueous-organic solvents with a liquid-to-gas volume ratio (bulk fraction; β) ranging between 0.0006 and 0. Read More

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An interpretation of alternative plugs flow liquid chromatography in a slightly modified GC/MS system.

Anal Sci 2009 Jun;25(6):743-52

Infra-red Spectroscopy Analytical Laboratory, 3-3-13 Chuo, Ebina, Kanagawa 243-0432, Japan.

Alternative plugs flow liquid chromatography (APFLC), a type of gas-liquid two-phase flow chromatography (2PFC) is achieved by the agglomeration of unformed condensates in an open tubular capillary column with intermittently alternating condensates in which the supply of the liquid is maintained at a level that provides a hypothetical homogeneous film, 25 to 150 nm thick, on the inner surface. To support stable plugs, the flow mode should normally be maintained at a liquid-to-gas volume ratio (beta) of between 0.0006 and 0. Read More

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Evaluation of styrene oligomers eluted from polystyrene for estrogenicity in estrogen receptor binding assay, reporter gene assay, and uterotrophic assay.

Food Chem Toxicol 2003 Jan;41(1):131-41

Central Research Institute, Nissin Food Products Co., Ltd, 2247, Noji-Cho, Kusatsu, Shiga 525-0055, Japan.

Styrene dimers (SDs) and styrene trimers (STs) eluted a little from polystyrene have been suspected of having estrogenic activity in the Wingspread Declaration [Our Stolen Futures, 1996] despite the lack of scientific analysis. Therefore, we have studied and reported styrene oligomers to have no endocrine disrupting effects [J. Food Hygienic Soc. Read More

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January 2003
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Monosaccharide analysis of glycoconjugates by anion exchange chromatography with pulsed amperometric detection.

Anal Biochem 1988 Apr;170(1):54-62

Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218.

The method of anion exchange chromatography followed by pulsed amperometric detection (AE-PAD; Johnson, D. C., and Polta, T. Read More

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