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Dermatology 2021 May 4:1-11. Epub 2021 May 4.

Department of Dermatology, MacKay Memorial Hospital, Taipei, Taiwan.

Background: Optical coherence tomography (OCT) has been shown to provide non-invasive diagnosis of common skin neoplasms, especially basal cell carcinoma. OCT produces a cross-sectional view of the tissue, similar to a traditionally sectioned histopathological view, but the resolution of conventional OCT is low and thus limits clinical application.

Objectives: This study aimed to investigate the application ability of a full-field (FF)OCT system which was newly developed to scan the skin at the cellular level. Read More

Ann Dermatol 2021 Apr 8;33(2):193-195. Epub 2021 Mar 8.

Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.

Dtsch Med Wochenschr 2021 Apr 30;146(9):603-607. Epub 2021 Apr 30.

Bundeswehrzentralkrankenhaus Koblenz, Abteilung I - Klinik für Innere Medizin.

History And Clinical Findings:  A 68-year-old male patient with psorias and a bullous pemphigoid as an underlying disease developed bilateral groundglass opacities on chest CT under longer-term, higher-dose immunosuppressive therapy with methylprednisolone with clinical symptoms of dry cough, progressive dyspnea and fever.

Diagnosis And Therapy:  After the exclusion of COVID-19, Pneumocystis jirovecii pneumonia (PCP) was detected and a corresponding high-dose therapy with trimethoprim-sulfamethoxazole was initiated promptly.

Course:  Nonetheless, a complicated course with bacterial superinfection and pulmonary aspergillosis as well as ARDS developed. Read More

J Clin Med 2021 Apr 28;10(9). Epub 2021 Apr 28.

Department of Dermatology, Venereology and Oncodermatology, University of Pécs Medical School Clinical Centre, H7632 Pécs, Hungary.

Bullous pemphigoid (BP) is an autoimmune blistering disease of elderly patients that has shown increasing incidence in the last decades. Higher prevalence of BP may be due to more frequent use of provoking agents, such as antidiabetic dipeptidyl peptidase-4 inhibitor (DPP4i) drugs. Our aim was to assess DPP4i-induced bullous pemphigoid among our BP patients and characterize the clinical, laboratory and histological features of this drug-induced disease form. Read More

Medicina (Kaunas) 2021 Apr 20;57(4). Epub 2021 Apr 20.

San Diego Family Dermatology, National City, CA 91950, USA.

Dyshidrosiform bullous pemphigoid is a variant of bullous pemphigoid. At least 84 patients with dyshidrosiform bullous pemphigoid have been described. Dyshidrosiform bullous pemphigoid usually presents with pruritic blisters in elderly individuals; the hemorrhagic or purpuric lesions on the palms and soles can be the only manifestation of the disease. Read More

J Eur Acad Dermatol Venereol 2021 Apr 29. Epub 2021 Apr 29.

Department of Dermatology, Technische Universität Dresden, Dresden, Germany.

Immune checkpoint inhibitors have revolutionized the treatment of metastatic melanoma . Long term benefit became possible with 5-year overall survival of more than 50% . However, the inhibition of T-cell regulation and ubiquitous immune activation may be accompanied by an autoimmune attack of other tissues besides the tumor, resulting side effects, which often have a great impact on patients' quality of life, may be life-threatening and even lead to discontinuation of the checkpoint inhibition therapy. Read More

J Dermatol 2021 Apr 29. Epub 2021 Apr 29.

Department of Dermatology, Takatsuki General Hospital, Takatsuki, Japan.

Fundam Clin Pharmacol 2021 Apr 29. Epub 2021 Apr 29.

Univ. Limoges, INSERM U1248 IPPRITT, F-87000, Limoges, France.

Background: Mycophenolate mofetil (MMF) is theoretically a treatment of choice for Mucous Membrane Pemphigoid (MMP), due to its good long-term tolerance and efficacy especially in elderly patients. However, no therapeutic monitoring is currently performed despite its large inter-individual variability.

Objectives: The aim of this study was to investigate the exposure/effect relationship based on the area under the curve (AUC) or trough level of mycophenolic acid in MMP patients. Read More

Ital J Dermatol Venerol 2021 Apr 29. Epub 2021 Apr 29.

Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.

Background: Mortality of bullous pemphigoid(BP) is a variable parameter,depending especially on the area where the study was conducted.The 1-year mortality rate and the identification of clinictherapeutic factors with potential prognostic value in patients with BP were evaluated in a cohort from a single referral center.

Methods: We have reviewed medical records of patients with BP diagnosed at the Sant'Orsola-Malpighi Hospital in Bologna(Italy) between 2005 and 2019. Read More

J Am Acad Dermatol 2021 Apr 24. Epub 2021 Apr 24.

Department of Dermatology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Tierarztl Prax Ausg G Grosstiere Nutztiere 2021 Apr 26;49(2):139-144. Epub 2021 Apr 26.

Klinik für Pferde, Innere Medizin, Justus-Liebig-Universität Gießen.

A 15-year-old Warmblood gelding was presented with multiple large, ulcerative, and crusty dermal lesions that had been existing for 4 years. Histopathology of a skin biopsy revealed cleft formation at the dermal-epidermal junction beneath the basal cells and above the basement membrane leading to the diagnosis of bullous pemphigoid. Immunosuppressive therapy with dexamethasone and azathioprine was initiated and after 14 weeks full remission of the ulcers was achieved. Read More

ORL J Otorhinolaryngol Relat Spec 2021 Apr 26:1-9. Epub 2021 Apr 26.

Department of Otolaryngology, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.

Background: Autoimmune bullous diseases are rare conditions characterized by blistering of the skin and mucous membranes. The 2 commonest forms are pemphigus vulgaris and bullous pemphigoid. The oral cavity or oropharynx may be the initial site of presentation or often the only site involved. Read More

Int J Womens Dermatol 2020 Dec 6;6(5):456-457. Epub 2020 Sep 6.

Department of Dermatology, Sapporo City General Hospital, Sapporo, Japan.

J Eur Acad Dermatol Venereol 2021 Apr 25. Epub 2021 Apr 25.

Lübeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.

Background: While clustering of bullous pemphigoid (BP) with neuropsychiatric diseases is well-established, the clinical and immunological profile of BP patients with this comorbidity remains to be decisively determined.

Objectives: To evaluate the burden of neurological and psychiatric comorbidities among patients with BP and to elucidate the clinical, immunological, and immunopathological features of patients with BP and comorbid neuropsychiatric conditions.

Methods: We performed a retrospective study encompassing patients diagnosed with BP throughout the years 2009-2020 in a specialized tertiary referral center. Read More

J Eur Acad Dermatol Venereol 2021 Apr 25. Epub 2021 Apr 25.

Lűbeck Institute of Experimental Dermatology, University of Lübeck, Lübeck, Germany.

Background: The influence of cutaneous cellular infiltration on the phenotype of bullous pemphigoid (BP) remains to be established.

Objectives: To evaluate the main histopathological characteristics of patients with BP and to assess the association between the composition of lesional inflammatory infiltrate and the various clinical, immunological, and immunopathological aspects of the disease.

Methods: Retrospective study encompassing patients diagnosed with BP throughout the years 2009-2020 in a specialized tertiary referral center. Read More

J Autoimmun 2021 Apr 20;120:102634. Epub 2021 Apr 20.

Vrije Universiteit Brussel (VUB), Skin Immunology & Immune Tolerance (SKIN) Research Group, Laarbeeklaan 103, 1090, Brussels, Belgium; Vrije Universiteit Brussel (VUB), Universitair Ziekenhuis Brussel (UZ Brussel), Department of Dermatology, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium. Electronic address:

Atopic dermatitis (AD) is an itchy, non-contagious relapsing and chronic inflammatory skin disease that usually develops in early childhood. This pathology is associated with food allergy, allergic asthma, allergic rhinitis and anaphylaxis which may persist in adulthood. The underlying mechanisms of AD (endotypes) are just beginning to be discovered and show a complex interaction of various pathways including skin barrier function and immune deviation. Read More

J Eur Acad Dermatol Venereol 2021 Apr 19. Epub 2021 Apr 19.

Skin Research Centre, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Dermatol Online J 2021 Mar 15;27(3). Epub 2021 Mar 15.

Department of Dermatology, University of Massachusetts Medical School, Worcester, MA.

Bullous pemphigoid (BP) most commonly presents as widespread, itchy, tense blisters in older patients. Localized bullous pemphigoid is a less common form of BP that can be more difficult to diagnose because of its similarity to more common conditions such as allergic contact dermatitis or bullous cellulitis. Prompt recognition of localized BP is important so that appropriate treatment can be started. Read More

J Am Acad Dermatol 2021 Apr 11. Epub 2021 Apr 11.

Division of Dermatology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA. Electronic address:

Despite the expansion of available in-vitro laboratory tests at a rate far exceeding that of dermatological pharmaceuticals, the existing literature is dominated by discussion of the latter. With the advent of numerous new tests, it can be difficult for practicing dermatologists to stay up to date on the available options, methodologies, and recommendations for when to order one test over another. Understanding inherent strengths and weaknesses of these options is necessary to inform appropriate ordering and proper interpretation of results. Read More

Int J Med Sci 2021 3;18(9):1946-1952. Epub 2021 Mar 3.

Department of pharmacy, The Affiliated Suzhou Science & Technology Town Hospital of Nanjing Medical University, Suzhou, 215153, China.

The world's first Diabetes Medications (Insulin) was marketed in October 1923. Some studies suggested the association of diabetes medications with Bullous Pemphigoid (BP), especially the Dipeptidyl Peptidase 4 (DPP-4) inhibitors. The study aims to detect an association between diabetes medications (focusing on DPP-4 inhibitors) and bullous pemphigoid based on FDA Adverse Event Reporting System (FAERS). Read More

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211008585

Texas Tech University Health Sciences Center, Amarillo, TX, USA.

Bullous pemphigoid (BP) is the most prevalent autoimmune blistering skin disease in the Western world affecting mainly the elderly population. The diagnosis is based on clinical assessment along with specific immunopathologic findings on skin biopsy. Risk factors include genetic factors, environmental exposures, and several infections including hepatitis B, hepatitis C, , , and cytomegalovirus. Read More

Front Immunol 2021 25;12:569287. Epub 2021 Mar 25.

Department of Dermatology and Allergology, Philipps-Universität Marburg, Marburg, Germany.

Bullous pemphigoid (BP) is a prototypic autoimmune disorder of the elderly, characterized by serum IgG autoantibodies, namely anti-BP180 and anti-BP230, directed against components of the basal membrane zone that lead to sub-epidermal loss of adhesion. Pruritus may be indicative of a pre-clinical stage of BP, since a subset of these patients shows serum IgG autoantibodies against BP230 and/or BP180 while chronic pruritus is increasingly common in the elderly population and is associated with a variety of dermatoses. Clinical and experimental evidence further suggests that pruritus of the elderly may be linked to autoimmunity with loss of self-tolerance against cutaneous autoantigens. Read More

Oral Dis 2021 Apr 9. Epub 2021 Apr 9.

Department of Oral Surgery, School of Dentistry at Matsudo, Nihon University, Matsudo, Japan.

Objective: The objective of this study was to evaluate the frequency of upper aerodigestive tract involvement in patients with mucous membrane pemphigoid associated with desquamative gingivitis.

Subjects And Methods: Data from 25 patients were collected by retrospective chart review. Their upper aerodigestive had been evaluated using a conventional flexible fiberscope. Read More

Acta Dermatovenerol Croat 2020 Dec;28(4):249-250

Hisayoshi Imanishi, MD, PhD, Division of Dermatology, Daito Central Hospital, 2-1-11 Ono, Daito, Osaka 574-0042, Japan;

Dear Editor, Dapsone is a dual-function drug with antimicrobial and antiprotozoal effects and anti-inflammatory features (1). In dermatology, it is a first choice for conditions such as leprosy, IgA pemphigus, dermatitis herpetiformis, and linear IgA bullous dermatosis, or an adjunctive treatment for, e.g. Read More

Dtsch Arztebl Int 2021 06;118(Forthcoming)

Background: Bullous autoimmune dermatoses are a clinically and immunopathologically heterogeneous group of diseases, characterized clinically by blisters or erosions of the skin and/or mucous membranes. In Germany, their prevalence is approximately 40 000 cases nationwide, and their incidence approximately 20 new cases per million people per year.

Methods: This review is based on publications that were retrieved by a selective search of the literature focusing on the current German and European guidelines. Read More

Ren Fail 2021 Dec;43(1):651-657

Apheresis and Dialysis Center, School of Medicine, Keio University, Tokyo, Japan.

Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease. Although several cases of BP in end-stage renal disease patients receiving peritoneal dialysis (PD) or hemodialysis have been reported, the incidence of BP in these patients remains unknown. We recently experienced three PD patients diagnosed with BP. Read More

J Am Acad Dermatol 2021 Apr 2. Epub 2021 Apr 2.

Department of Dermatology, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Background: A variety of dermatoses have been reported in the growing number of patients treated with immune-checkpoint inhibitors (ICIs), but the current understanding of cutaneous immune-related adverse events (irAEs) is limited.

Objective: To determine the cumulative incidence, distribution, and risk factors of cutaneous irAEs after ICI initiation.

Methods: This was a retrospective cohort study of patients in a national insurance claims database including cancer patients treated with ICIs and matched controls. Read More

Mov Disord Clin Pract 2021 Apr 25;8(3):445-448. Epub 2021 Feb 25.

Department of Neurology Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust Salford United Kingdom.

Background: Bullous pemphigoid (BP) is an autoimmune blistering dermatosis associated with a number of neurological conditions, including idiopathic Parkinson's disease (IPD). Only 1 case of BP in a patient with multiple system atrophy (MSA) has been reported.

Cases: We report 3 cases of men with probable MSA who developed bullous pemphigoid at a latency of 4-6 years from MSA symptom onset. Read More

Clin Exp Dermatol 2021 Apr 3. Epub 2021 Apr 3.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Mucous Membrane Pemphigoid (MMP) comprises a group of auto-antibody mediated subepidermal bullous diseases characterized by predominant involvement of mucous membranes and a tendency to scarring. Rituximab (RTX) has emerged as a potential therapeutic solution for MMP. However, the literature regarding its efficacy is sparse. Read More

Br J Dermatol 2021 Apr 2. Epub 2021 Apr 2.

Department of Dermatology, Kurume University School of Medicine, Kurume University Institute of Cutaneous Cell Biology, Kurume, Fukuoka, Japan.

Mucous membrane pemphigoid (MMP) is a heterogeneous group of subepidermal autoimmune bullous skin disease (AIBD), which affects mainly various mucous membranes and occasionally skin. Although oral mucosa is most commonly affected, ocular, nasal, pharyngeal, laryngeal, esophageal and genital mucosae are also involved.. Read More