12,986 results match your criteria Bullous Disease of Diabetes


Whole exome sequencing identified two point mutations of COL7A1 and FLG in a Chinese family with dystrophic epidermolysis bullous pruriginosa and ichthyosis vulgaris.

J Dermatol 2018 Dec 14. Epub 2018 Dec 14.

Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, China.

We report a 21-year-old man with recurrent bullous eruptions and severe itching on the lower legs and feet since 5 years of age. Dry, dirty brown, tile-like scales covered his lower legs with dystrophic toenails. Nodular prurigo-like lesions, scarring papules and milia remitted after the bullous eruptions. Read More

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December 2018

Higher frequency of dipeptidyl peptidase IV inhibitor intake in bullous pemphigoid patients than in the French general population.

J Invest Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Department of Dermatology, Rouen University Hospital and INSERM U1234, Centre de référence des maladies bulleuses autoimmunes, Normandie University, Rouen.

Dipeptidyl-peptidase-IV-inhibitors have been suspected to induce bullous pemphigoid (BP). The objective of this study was to compare the observed frequency of gliptin intake in a large sample of 1787 BP patients diagnosed between 2012 and 2015 in France, with the expected frequency after indirect age standardization on 225412 individuals extracted from the database of the National Healthcare Insurance Agency. The secondary objective was to assess the clinical characteristics and the course of gliptin-associated BP depending on whether gliptin was continued or stopped. Read More

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December 2018

Complement-Activating Capacity of Autoantibodies Correlates With Disease Activity in Bullous Pemphigoid Patients.

Front Immunol 2018 20;9:2687. Epub 2018 Nov 20.

Department of Dermatology, Medical Faculty, Medical Center - University of Freiburg, Freiburg, Germany.

Bullous pemphigoid is a subepidermal blistering skin disease, associated with autoantibodies to hemidesmosomal proteins, complement activation at the dermal-epidermal junction, and dermal granulocyte infiltration. Clinical and experimental laboratory findings support conflicting hypotheses regarding the role of complement activation for the skin blistering induced by pemphigoid autoantibodies. In-depth studies on the pathogenic relevance of autoimmune complement activation in patients are largely lacking. Read More

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November 2018

Recurrent Bullous Eruption in a Young Woman.

JAMA Dermatol 2018 Dec 12. Epub 2018 Dec 12.

Department of Dermatology, University Hospital Leipzig (UKL), Germany.

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December 2018

Exosomes in chronic inflammatory skin diseases and skin tumors.

Exp Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Exosomes are a type of endosome that can mediate communication between cells and the transport of cellular components such as microRNAs, mRNAs, proteins and DNA. Recently, exosomes have been under investigation for their significant roles in both healthy physiology and disease states. Herein, we review the role of exosomes in chronic inflammatory skin diseases and skin tumors, especially focusing on systemic lupus erythematosus, psoriasis, atopic dermatitis, bullous pemphigoid and melanoma. Read More

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December 2018
1 Read

Femtosecond Laser-Assisted Deep Lamellar Descemet Membrane Endothelial Keratoplasty for the Treatment of Endothelial Dysfunction Associated With Posterior Stromal Scarring.

Cornea 2018 Dec 7. Epub 2018 Dec 7.

Cornea, Cataract and Refractive Surgery Unit, Vissum Corporación, Alicante, Spain.

Purpose: To describe an alternative surgical approach, femtosecond laser-assisted deep lamellar Descemet membrane endothelial keratoplasty (Femto-DL-DMEK), for the treatment of corneal endothelial diseases associated with posterior stromal scarring.

Methods: Case report of a 52-year-old man with pseudophakic bullous keratopathy and posterior corneal scarring secondary to viral endotheliitis who underwent Femto-DL-DMEK. The surgical technique was as follows: First, a manual lamellar dissection plane was created at approximately 75% to 85% depth through a 5. Read More

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December 2018

Infliximab-induced bullous pemphigoid and anti-desmoglein 3 and anti-BP180 autoantibodies in a patient with ulcerative colitis.

Eur J Dermatol 2018 Dec 10. Epub 2018 Dec 10.

Division of Dermatology, Department of Medicine of Sensory and Motor Organs, Faculty of Medicine, Tottori University, Yonago, Japan.

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December 2018

The incidence of herpes zoster in cutaneous lupus erythematosus (CLE), dermatomyositis (DM), pemphigus vulgaris (PV), and bullous pemphigoid (BP).

Authors:
Eden Lake

J Am Acad Dermatol 2018 Dec 3. Epub 2018 Dec 3.

Loyola Univ Medical Center Dermatology, 321 N La Grange Rd, La, Grange Park, IL. Electronic address:

The incidence of zoster is increased in many autoimmune diseases. This study found a significantly increased zoster incidence in dermatomyositis and cutaneous lupus erythematosus compared with a control group.Physicians should be aware of this risk and consider administering the vaccine against zoster to these patients if not contraindicated. Read More

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December 2018
7 Reads

Dermatologic manifestations in end stage renal disease.

Hemodial Int 2018 Dec 6. Epub 2018 Dec 6.

Department of Nephrology, Cleveland Clinic Akron General, Akron, Ohio, USA.

Skin manifestations are commonly seen in end stage renal disease (ESRD). Skin involvement in this population can be extensive and dramatically worsen quality of life. Close observation of the skin and nails of ESRD patients by clinicians allows for timely diagnosis and treatment, which ultimately improves quality of life and reduces mortality. Read More

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December 2018
4 Reads

[Immunoadsorption in dermatology].

Hautarzt 2018 Dec 5. Epub 2018 Dec 5.

Klinik für Dermatologie, Allergologie und Venerologie, Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Deutschland.

Autoimmmune bullous diseases are mediated by pathogenetically relevant autoantibodies against components of the epidermis and/or superficial mucous membranes (in pemphigus) and structural proteins of the dermal-epidermal junction (in pemphigoid diseases). Using immunoadsorption (IA), an already well-established procedure in cardiac and rheumatic disorders, antibodies can be removed from the plasma. At present, most data on the adjuvant use of IA in dermatology are derived from patients with severe and/or refractory pemphigus vulgaris or pemphigus foliaceus and also from patients with pemphigoid diseases. Read More

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December 2018
1 Read

Epithelial ingrowth through venting incision into laser-assisted in situ keratomileusis flap interface after descemet stripping automated endothelial keratoplasty.

Am J Ophthalmol Case Rep 2019 Mar 14;13:25-27. Epub 2018 Nov 14.

Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, 21287, USA.

Purpose: To present a case of epithelial ingrowth into the laser-assisted in situ keratomileusis (LASIK) flap interface after a patient underwent descemet stripping automated endothelial keratoplasty (DSAEK) surgery with venting incisions.

Observations: We present a case of a 48-year-old man with previous history of LASIK that underwent DSAEK for pseudophakic bullous keratopathy after complicated cataract surgery requiring an intraocular lens (IOL) exchange. The patient developed epithelial ingrowth into the LASIK flap interface from one of the venting incisions. Read More

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March 2019
2 Reads

"PI-less DMEK": results of Descemet's membrane endothelial keratoplasty (DMEK) without a peripheral iridotomy.

Eye (Lond) 2018 Dec 5. Epub 2018 Dec 5.

Department of Ophthalmology, Rabin Medical Center, Petach Tikva, Israel.

Purpose: To assess Descemet's membrane endothelial keratoplasty (DMEK) without performing a peripheral iridotomy (PI) prior to or during surgery ("PI-less DMEK").

Materials And Methods: This retrospective study included consecutive patients that underwent PI-less DMEK by a single surgeon (E.L) between February 2016 and February 2017 at the Rabin Medical Center, a Tertiary Hospital. Read More

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December 2018
3 Reads

Comparing early and late treatments with rituximab in pemphigus vulgaris: which one is better?

Arch Dermatol Res 2018 Dec 1. Epub 2018 Dec 1.

Autoimmune Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences, Vahdate-Eslami Square, Tehran, 11996, Iran.

During the last decade, successfully treatment of patients diagnosed with pemphigus vulgaris (PV) with rituximab (RTX) was reported by several authors. The present study has been designed to compare the clinical outcomes and RTX-related side effects between the two groups of early treated (≤ 6 months) and lately treated PV (> 6 months) patients with RTX. We did a retrospective study between Oct 2014 and Jun 2016 to compare the short-term efficacy and safety of RTX in PV diagnosed patients. Read More

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December 2018
2 Reads

Combined flanged intrascleral intraocular lens fixation with corneal transplant.

Am J Ophthalmol Case Rep 2019 Mar 10;13:1-5. Epub 2018 Nov 10.

Medical University of South Carolina, USA.

Purpose: To report clinical outcomes and surgical technique of flanged intrascleral intraocular lens fixation with double-needle combined with either penetrating keratoplasty (PKP) or ultrathin Descemet-stripping automated endothelial keratoplasty (UT-DSAEK).

Observations: Five patients underwent combined flanged intrascleral intraocular lens fixation with double-needle technique and keratoplasty. Three patients underwent triple procedure (open sky intrascleral intraocular lens fixation with double-needle and PKP) secondary to ocular trauma or a failed corneal transplant. Read More

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March 2019
2 Reads

Chronic pulmonary aspergillosis following pulmonary embolism.

Med Mycol Case Rep 2019 Mar 9;23:20-22. Epub 2018 Nov 9.

Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre, United Kingdom.

Chronic pulmonary aspergillosis (CPA) is predominantly found alongside cavitating or bullous lung diseases. Although pulmonary embolism may cause cavitation, an association with CPA has not been well described. We describe a case of CPA in a 79-year-old female following bilateral pulmonary emboli. Read More

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March 2019
1 Read

New trends in corneal transplants at the University of Toronto.

Can J Ophthalmol 2018 Dec 9;53(6):580-587. Epub 2018 May 9.

Keenan Research Centre at the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Ont; Department of Ophthalmology and Vision Sciences, Faculty of Medicine, University of Toronto, Toronto, Ont; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, Ont; Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.. Electronic address:

Objective: To assess trends in surgical procedures and indications for all corneal transplants performed at the University of Toronto.

Design: Retrospective cross-sectional study.

Participants: One thousand one hundred and four consecutive corneal transplants performed at the Kensington Eye Institute (KEI). Read More

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December 2018
1 Read

Analysis of penetrating keratoplasty in Northern Alberta, Canada, from 2000 to 2015.

Can J Ophthalmol 2018 Dec 10;53(6):568-573. Epub 2018 Apr 10.

Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Alta.. Electronic address:

Objective: To study indications for penetrating keratoplasty (PK) at a single site. The trends in the causative organisms for infectious keratitis requiring surgery were also evaluated.

Design: Retrospective observational study. Read More

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December 2018
1 Read
1.299 Impact Factor

Clinical outcomes of Descemet membrane endothelial keratoplasty in eyes with a glaucoma drainage device.

Am J Ophthalmol 2018 Nov 28. Epub 2018 Nov 28.

Netherlands Institute for Innovative Ocular Surgery (NIIOS), Rotterdam, The Netherlands; Melles Cornea Clinic Rotterdam, The Netherlands; Amnitrans Eye Bank Rotterdam, The Netherlands; NIIOS-USA, San Diego, USA. Electronic address:

Purpose: To evaluate the feasibility and clinical outcomes of Descemet membrane endothelial keratoplasty (DMEK) in eyes with a glaucoma drainage device (GDD).

Design: Retrospective, interventional case series.

Methods: Clinical outcomes of 23 DMEK procedures for bullous keratopathy (52%), failed previous transplant (39%) or Fuchs endothelial corneal dystrophy (9%) in 20 eyes (19 patients) with a GDD were retrospectively analyzed at two tertiary referral centers. Read More

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November 2018
1 Read

Generalized pustular psoriasis complicated with bullous pemphigoid.

Int J Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Division of Dermatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

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December 2018

Downregulation of aquaporin 3 in bullous pemphigoid patients.

Arch Dermatol Res 2018 Dec 4. Epub 2018 Dec 4.

Department of Dermatology, Faculty of Medicine Cairo University, Kasr Al Ainy Hospital, Al Manial, Cairo, 11956, Egypt.

Bullous pemphigoid (BP) is a chronic autoimmune skin disease. Aquaporin 3 (AQP 3) has a possible role in the pathogenesis of many dermatological diseases. In this work, we aimed to evaluate the expression of AQP 3 in BP. Read More

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December 2018
5 Reads

Bullous pemphigoid, a dermatosis of the elderly

Rev Prat 2017 12;67(10):1080-1083

Département de dermatologie, centre hospitalier universitaire de Rouen ; Inserm U1234, Institut de recherche et d'innovation biomédicale, université de Rouen, Rouen, France.

Bullous pemphigoid, a dermatosis of the elderly. Bullous pemphigoid is the most common autoimmune bullous disease and affects almost exclusively the elderly. Its occurrence is related to the presence of pathogenic autoantibodies directed against structural proteins (BP180 and BP230) of the protein adhesion complex of the dermo-epidermal junction: the hemi-desmosome. Read More

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December 2017
5 Reads

Pruritus of the elderly

Authors:
Laurent Misery

Rev Prat 2017 12;67(10):1076-1079

Service de dermatologie, CHU de Brest, Brest, France.

Pruritus of the elderly. Pruritus is defined as an unpleasant sensation that causes the need for scratching. In the elderly, it is frequently encountered. Read More

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December 2017
5 Reads

Drug-induced linear IgA bullous dermatosis: a French retrospective pharmacovigilance study of 69 cases.

Br J Clin Pharmacol 2018 Dec 4. Epub 2018 Dec 4.

EA 7379 EpiDermE, Université Paris Est Créteil Val de Marne UPEC, Créteil, France.

Aims: Linear immunoglobin A (IgA) bullous dermatosis (LABD) is a rare autoimmune dermatosis considered spontaneous or drug-induced (DILAD). We assessed all DILAD cases, determined the imputability score of drugs, highlighted suspected drugs.

Methods: Data for patients with DILAD were collected retrospectively from the French Pharmacovigilance network (from 1985 to 2017) and from physicians involved in the Bullous Diseases French Study Group and the French Investigators for Skin Adverse Reactions to Drugs. Read More

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December 2018
2 Reads

Diagnostic histochemistry in non-neoplastic skin diseases.

Semin Diagn Pathol 2018 Nov 16;35(6):390-398. Epub 2018 Oct 16.

PRW Laboratories, Charlottesville, VA, USA.

Non-neoplastic skin lesions comprise a sizable group of disorders with variable etiologies and clinical manifestations. They can be grouped into vesiculopustular dermatitides; spongiotic and psoriasiform diseases; lichenoid dermatitides; lymphoid infiltrates of the dermis; granulomatous processes; bullous disorders; vasculopathies; panniculitides; deposition disorders; and defects in maintenance of dermal connective tissue. The use of histochemical methods continues to be an indispensable adjunct to conventional microscopy in the further characterization of such lesions. Read More

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November 2018
2 Reads

[Comparative analysis of modern methods of preparing donor material for endothelial keratoplasty].

Vestn Oftalmol 2018 ;134(5. Vyp. 2):202-207

I.M. Sechenov First Moscow Medical University, 8-2 Trubetskaya St., Moscow, Russian Federation, 119991.

Purpose: To evaluate various methods of stripping Descemet's membrane of a donor corneoscleral flap for Descemet's membrane endothelial keratoplasty (DMEK).

Material And Methods: The study included 60 corneoscleral flaps (mean donor age was 62.9 years) from the eye bank of Research Institute of Eye Diseases, which were not suitable for clinical use due to positive serological results. Read More

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January 2018
3 Reads

The Effect of Donor- and Recipient-Related Factors on Corneal Graft Survival in Penetrating Keratoplasty.

Semin Ophthalmol 2018 Nov 29:1-8. Epub 2018 Nov 29.

a Department of Ophthalmology , Bozyaka Training and Research Hospital , İzmir , Turkey.

Purpose: To investigate the impact of donor and recipient factors on graft survival in penetrating keratoplasty (PK).

Material And Methods: This retrospective study included 365 eyes that underwent PK using corneas from 231 donors between June 2010 and June 2015. Patients were divided into three groups (group 1: primary endothelial diseases; group 2: iatrogenic endothelial disorders; and group 3: other pathologies with a healthy endothelium) according to PK indications. Read More

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November 2018
1 Read

A rare cutaneous adverse effect secondary to cabozantinib therapy.

Oxf Med Case Reports 2018 Dec 26;2018(12):omy105. Epub 2018 Nov 26.

Department of Oncology, Bristol Haematology and Oncology Centre, Horfield Road, Bristol, UK.

Cabozantinib is a tyrosine kinase inhibitor which is increasingly being used for the treatment of metastatic renal cell cancer. Skin toxicity such as palmar-plantar erythrodysesthesia is not uncommon with such agents. However, bullous skin reactions are not common and we report the case of a patient with metastatic renal cell cancer who experienced such cutaneous toxicity. Read More

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December 2018
1 Read

Cutaneous manifestations of hematologic malignancies the experience of an Italian dermatology department.

Hematol Oncol 2018 Nov 28. Epub 2018 Nov 28.

Di.S.Sal. Section of Dermatology, University of Genoa, San Martino Polyclinic Hospital, Genoa, Italy.

In recent years, dermatologic manifestations in oncohematologic patients have become more common. The aim of our study was to determine the incidence and heterogeneity of skin manifestations in patients followed at our Hematology Department. This observational monocentrical study was conducted on 60 patients. Read More

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November 2018
4 Reads

Association of Transient Palmoplantar Keratoderma With Clinical and Immunologic Characteristics of Bullous Pemphigoid.

JAMA Dermatol 2018 Nov 28. Epub 2018 Nov 28.

Department of Dermatology, Reims University Hospital, University of Reims Champagne-Ardenne, Reims, France.

Importance: Development of transient palmoplantar keratoderma (PPK) with bullous pemphigoid (BP) has only been described in 2 isolated case reports. The clinical significance and the pathophysiologic mechanisms of this association are unknown.

Objective: To examine the clinical characteristics and immunological profile of patients with BP who develop transient PPK and analyze therapeutic options and outcomes. Read More

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November 2018
1 Read

The potential roles of herpesvirus and cytomegalovirus in the exacerbation of pemphigus vulgaris.

Dermatol Pract Concept 2018 Oct 31;8(4):262-271. Epub 2018 Oct 31.

Autoimmune Bullous Disease Research Center, Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background: Among exogenous etiologies, the critical role of microbial agents such as herpesviruses (HSV1/2) and cytomegalovirus (CMV) in triggering and flaring autoimmune conditions such as pemphigus vulgaris (PV) has been recently discovered.

Objectives: The present study aimed to investigate the plausible role of these viruses in the exacerbation of PV using serological and molecular methods.

Patients/methods: Sixty patients with PV (30 with relapse type and 30 with remission type) were recruited for the purpose of this case-control study. Read More

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October 2018
5 Reads

Bullous Diabeticorum.

J Am Osteopath Assoc 2018 Dec;118(12):832

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December 2018
1 Read

Perspective From the 5th International Pemphigus and Pemphigoid Foundation Scientific Conference.

Front Med (Lausanne) 2018 8;5:306. Epub 2018 Nov 8.

Department of Dermatology, University of Pennsylvania, Philadelphia, PA, United States.

The 5th Scientific Conference of the International Pemphigus and Pemphigoid Foundation (IPPF), "Pemphigus and Pemphigoid: A New Era of Clinical and Translational Science" was held in Orlando, Florida, on May 15-16, 2018. Scientific sessions covered recent, ongoing, and future clinical trials in pemphigus and bullous pemphigoid, disease activity and quality of life instruments, and the IPPF Natural History Study. Furthermore, the meeting provided an opportunity to hear firsthand from patients, investigators, and industry about their experience enrolling for clinical trials. Read More

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November 2018
5 Reads

Trace element profile in pemphigus foliaceus and in pemphigus vulgaris patients from Southeastern Brazil.

J Trace Elem Med Biol 2019 Jan 24;51:31-35. Epub 2018 Sep 24.

Laboratory of the Division of Dermatology, University Hospital, Ribeirão Preto Medical School, Avenida Bandeirantes, 3900, 14049-900, Ribeirão Preto, São Paulo, Brazil.

Pemphigus foliaceus (PF) and pemphigus vulgaris (PV) are autoimmune bullous diseases; they are endemic in the northeastern region of the state of São Paulo, Southeastern Brazil. Patients' copper (Cu), zinc (Zn), and selenium (Se) metabolic deficiencies have already been associated with PV pathogenesis in the Middle East but not in Brazil. Lead (Pb), Cu, Zn, and Se concentrations were determined in whole blood or serum samples obtained from 56 PV patients, 62 PF patients, and 135 healthy controls from the endemic region and compared. Read More

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January 2019
1 Read

Going Viral 2019: Zika, Chikungunya, and Dengue.

Dermatol Clin 2019 Jan;37(1):95-105

Department of Dermatology, University Hospital "Dr. José E. González", Universidad Autónoma de Nuevo León, Mitras Centro, Avenida Gonzalitos y Madero S/N, Monterrey 64460, Mexico.

Chikungunya and Zika virus infections are emerging diseases in the Americas, and dengue continues to be the most prevalent arthropod-borne virus in the world. These arbovirus diseases may spread by endemic transmission or as travel-related infections and have rapidly expanded their geographic distribution secondary to vector spread. All 3 share a similar clinical picture that includes a maculopapular rash. Read More

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January 2019
14 Reads

Linear IgA Bullous Dermatosis Preceding the Diagnosis of Primary Sclerosing Cholangitis and Ulcerative Colitis: A Case Report.

Am J Dermatopathol 2018 Nov 15. Epub 2018 Nov 15.

Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA.

Linear IgA bullous dermatosis (LABD) is a rare autoimmune blistering disorder seen in the pediatric and adult populations that is often linked to a medication, infection, or underlying gastrointestinal, hepatobiliary, or autoimmune disease. In this study, we describe the case of a 23-year-old white man whose presentation and diagnosis of LABD ultimately led to the discovery of underlying primary sclerosing cholangitis (PSC) and ulcerative colitis (UC). His dermatitis resolved with topical steroids and dapsone, and he is undergoing systemic treatment for his UC and PSC. Read More

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November 2018
1 Read

["Decoratively figured blisters" on the whole integument in initially diagnosed ulcerative colitis].

Hautarzt 2018 Nov 20. Epub 2018 Nov 20.

Klinik- und Poliklinik für Haut- und Geschlechtskrankheiten, Universitätsmedizin Greifswald, Greifswald, Deutschland.

The rare case of a 61-year-old patient suffering from linear IgA dermatosis is presented. The patient was previously hospitalized with chronic inflammatory bowel disease. The correct diagnosis of the disease was based on clinical and histological findings. Read More

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November 2018
2 Reads

A case of entecavir-associated bullous fixed drug eruption and a review of literature.

Turk J Gastroenterol 2018 Nov 19. Epub 2018 Nov 19.

Department of Pathology, Necmettin Erbakan University School of Medicine, Konya, Turkey.

Fixed drug eruption (FDE) is a type of drug reaction characterized by localized erythema, hyperpigmentation, and bullous at the same site(s), generally observed following every intake of a causative drug. Delayed-type cellular hypersensitivity (Type IVC) is considered to play a role in FDE etiology. Several antibiotics, barbiturates, oral contraceptives, nonsteroidal anti-inflammatory drugs, laxative-containing phenolphthalein, metronidazole, and quinine are known to be the primary drugs responsible for FDE. Read More

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November 2018
6 Reads

Oral administration of the selective GPR120/FFA4 agonist compound A is not effective in alleviating tissue inflammation in mouse models of prototypical autoimmune diseases.

Pharmacol Res Perspect 2018 Dec 8;6(6):e00438. Epub 2018 Nov 8.

Department of Dermatology, Allergy, and Venereology University of Lübeck Lübeck Germany.

ω3-polyunsaturated free fatty acids (ω3-PUFAs), particularly docosahexaenoic (DHA) and eicosapentaenoic acid (EPA), are thought to exert health promoting effects in metabolic and in inflammatory diseases. The molecular mechanisms of these beneficial effects are only partially understood. DHA and EPA activate (GPR120/FFA4). Read More

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December 2018
4 Reads

Rash induced by enteral vancomycin therapy in an older patient in a long-term care ventilator unit: case report and review of the literature.

Allergy Asthma Clin Immunol 2018 6;14:73. Epub 2018 Nov 6.

Chronic Ventilator Unit, Herzog Medical Center, Givat Shaul St, POB 3900, 91035 Jerusalem, Israel.

Background: Oral vancomycin is a first-line treatment for severe colitis. Oral vancomycin is perceived to lack systemic absorption or systemic adverse effects; however, a few cases of hypersensitivity to oral vancomycin have been reported, all in hospitalized patients.

Case Presentation: In the present case, a 66-year-old woman with end-stage neurodegenerative disease residing in a long-term care facility developed a maculopapular rash following treatment with enteral vancomycin for recurrent colitis. Read More

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November 2018
5 Reads

A Rabbit Corneal Endothelial Dysfunction Model Using Endothelial-Mesenchymal Transformed Cells.

Sci Rep 2018 Nov 15;8(1):16868. Epub 2018 Nov 15.

Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.

Unlike humans, rabbit corneal endothelial wounds are known to spontaneously heal. The current study was aimed to develop a new rabbit bullous keratopathy model using corneal endothelial cells that were induced to undergo endothelial-mesenchymal transformation (EMT). EMT was induced in rabbit corneal endothelial cells (RCECs) by culturing with TGFβ and basic FGF Supplemented Medium. Read More

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November 2018
4 Reads

Generalized bullous fixed drug eruption due to ibuprofen.

Contact Dermatitis 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatovenereology, Hospital de Braga, Braga, Portugal.

Ibuprofen can cause a wide variety of cutaneous reactions with a relatively high frequency, but establishing the causal relationship is usually difficult [1]. We report a case of a skin drug reaction due to ibuprofen, confirmed by positive patch test results. Read More

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November 2018
3 Reads

Gastro-intestinal involvement in Stevens-Johnson syndrome and toxic epidermal necrolysis : a retrospective case series.

Br J Dermatol 2018 Nov 15. Epub 2018 Nov 15.

Service de Réanimation Médicale, Hôpitaux Universitaires Henri Mondor - Albert Chenevier, Assistance Publique - Hôpitaux de Paris (AP-HP), Créteil, France.

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are characterized by extensive skin and mucosal membrane detachment together with specific visceral involvement. While respiratory tract and ear, nose, and throat mucosal lesions have been comprehensively described, gastro-intestinal (GI) involvement, although previously reported, has been less investigated. Clinical manifestations are non-specific, including ileus, emesis, diarrhea, hematemesis, melena/rectal bleeding, abdominal pain, or dysphagia. Read More

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November 2018
2 Reads

Fc-binding proteins enhance autoantibody-induced BP180 depletion in pemphigoid.

J Pathol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, Hokkaido University Graduate School of Medicine.

Immunoglobulins consist of two antigen-binding regions (Fab) and one constant region (Fc). Protein A and protein G are bacterial proteins used for the purification of IgG by virtue of their high affinities for Fc fragment. Rheumatoid factors are autoantibodies against IgG Fc fragments, which are present in the body under physiological conditions. Read More

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November 2018
7 Reads

"Ghost DMEK" Technique: Circular Peripheral Staining of Descemet's Membrane Endothelial Keratoplasty Grafts.

Cornea 2018 Nov 12. Epub 2018 Nov 12.

Department of Ophthalmology, Rabin Medical Center, Petach Tikva, Israel.

Purpose: To describe the ghost Descemet's membrane endothelial keratoplasty (DMEK) technique that allows for real-time evaluation of DMEK graft orientation, location, and folding status within the anterior chamber, by simple observation at the surgical microscope.

Methods: This is a retrospective case series done in a university hospital. The study included 10 patients who underwent ghost DMEK surgery because of corneal endothelial insufficiency for Fuchs' endothelial dystrophy (N = 5), pseudophakic bullous keratopathy (N = 2), and failed previous posterior lamellar keratoplasty (N = 3). Read More

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November 2018
4 Reads

Rituximab and Omalizumab for the Treatment of Bullous Pemphigoid: A Systematic Review of the Literature.

Am J Clin Dermatol 2018 Nov 13. Epub 2018 Nov 13.

Department of Dermatology, Beilinson Hospital, Rabin Medical Center, Petah-Tikva, 49100, Israel.

Background: Bullous pemphigoid (BP) is the most common autoimmune blistering skin disease worldwide. Systemic corticosteroids are considered the mainstay of therapy; however, they may cause significant adverse effects and treatment failures, so additional therapeutic modalities with better safety profiles are required. Rituximab and omalizumab are novel biologic agents administered in recent years for the treatment of BP, yet data regarding their use in the disease are limited. Read More

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November 2018
5 Reads

Reply to: "Comment on 'Oral diabetes medications other than dipeptidyl peptidase-4 inhibitors are not associated with bullous pemphigoid: A Finnish nationwide case control study'".

J Am Acad Dermatol 2018 Dec;79(6):e113-e114

PEDEGO Research Unit, University of Oulu, Department of Dermatology and Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland.

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December 2018
4 Reads

Comment on "Oral diabetes medications other than dipeptidyl peptidase-4 inhibitors are not associated with bullous pemphigoid: A Finnish nationwide case control study".

Authors:
Khalaf Kridin

J Am Acad Dermatol 2018 Dec;79(6):e111-e112

Department of Dermatology, Rambam Health Care Campus, Haifa, Israel and the School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel. Electronic address:

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December 2018
7 Reads

A Case of Acute Pemphigus Vulgaris Relapses Associated with Cocaine Use and Review of the Literature.

Dermatol Ther (Heidelb) 2018 Dec 10;8(4):653-663. Epub 2018 Nov 10.

Department of Neurology, Alzheimer Research Center Groningen, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Pemphigus is a bullous autoimmune disease that affects the skin and mucous membranes. It is very difficult to establish the etiology and the triggering factors that influence reactivations in pemphigus vulgaris (PV). The case of a 33-year-old male with chronic history of intranasal cocaine consumption is presented in this report. Read More

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December 2018
7 Reads

Challenging cause of bullous eruption of the hands in the Arctic.

BMJ Case Rep 2018 Nov 8;2018. Epub 2018 Nov 8.

Department of Dermatology and Venereology, Aarhus University Hospital, Aarhus, Denmark.

Phytophotodermatitis is caused by deposition of photosensitising compounds on the skin followed by ultraviolet exposure. We present an unusual case of a 29-year-old Australian male visiting Greenland who presented with severe itchy bullous eruption on his hands. The cause was a combination of exposure to lime fruit juice and prolonged sun exposure from the Arctic midnight sun. Read More

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November 2018
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