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    Bullous Pemphigoid Triggered by Thermal Burn Under Medication With a Dipeptidyl Peptidase-IV Inhibitor: A Case Report and Review of the Literature.
    Front Immunol 2018 12;9:542. Epub 2018 Apr 12.
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
    Bullous pemphigoid (BP) is a common autoimmune blistering disease in which autoantibodies mainly target the hemidesmosomal component BP180 (also known as type XVII collagen) in basal keratinocytes. Various triggering factors are known to induce BP onset, including radiotherapy, burns, ultraviolet exposure, surgery, and the use of dipeptidyl peptidase-IV inhibitors (DPP4i), which are widely used antihyperglycemic drugs. Here, we present a case of BP triggered by a thermal burn under medication with DPP4i. Read More

    Comorbidities of bullous pemphigoid in a Finnish cohort.
    Eur J Dermatol 2018 Apr;28(2):157-161
    University of Helsinki and Helsinki University Central Hospital, Department of Dermatology, Allergology and Venereology, 00029 HUS, Finland.
    The incidence of bullous pemphigoid (BP) is increasing in Finland. To investigate the clinical presentation, comorbidities, and medications in a cohort of Finnish patients with confirmed BP managed in a university hospital setting. An observational retrospective study of all consecutive patients diagnosed with BP in 2012-2013 at the Department of dermatology, HUCH. Read More

    Decrease in eosinophils infiltrating into the skin of patients with dipeptidyl peptidase-4 inhibitor-related bullous pemphigoid.
    J Dermatol 2018 May 6;45(5):596-599. Epub 2018 Feb 6.
    Department of Dermatology, Teikyo University School of Medicine, Tokyo, Japan.
    Bullous pemphigoid (BP) is an acquired autoimmune blistering disease in which autoantibodies against epitopes in the basement membrane zone of the skin such as BP180 or BP230 are produced. Dipeptidyl peptidase (DPP)-4 inhibitors have become commonly used to treat diabetes. As DPP-4 inhibitors are more commonly prescribed for diabetes, BP related to DPP-4 inhibitors has been reported and has attracted attention. Read More

    Mortality and Comorbidity Profiles of Patients with Bullous Pemphigoid in Korea.
    Ann Dermatol 2018 Feb 26;30(1):13-19. Epub 2017 Dec 26.
    Department of Dermatology, Chonnam National University Medical School, Gwangju, Korea.
    Background: Bullous pemphigoid (BP) is a common autoimmune-mediated blistering skin disease that is significantly associated with mortality and morbidity. However, few studies regarding the mortality and comorbidity profiles of BP have been reported in Korea.

    Objective: To evaluate and compare the mortality, comorbidity profiles, and risk factors between patients with BP who visited our clinic and an age-matched general population of Korea. Read More

    Lichen planus pemphigoides treated with ustekinumab.
    Cutis 2017 Dec;100(6):415-418
    Advanced Desert Dermatology/Midwestern University, Glendale, Arizona, USA.
    A 71-year-old woman presented with pink to violaceous, flat-topped, polygonal papules on the volar wrists, extensor elbows, and bilateral lower legs of 3 years' duration. She also had erythematous, violaceous, infiltrated plaques with microvesiculation on the bilateral thighs of several months' duration. She reported pruritus, burning, and discomfort. Read More

    Lichen Planus Pemphigoides Induced by Enalapril: A Case Report and a Review of Literature.
    Case Rep Dermatol 2017 Sep-Dec;9(3):217-224. Epub 2017 Oct 31.
    Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
    Lichen planus pemphigoides (LPP) is a rare autoimmune bullous dermatosis. The clinical presentation of LPP may mimic bullous pemphigoid making the diagnosis difficult. A thorough clinical, histopathological, and immunological evaluation is essential for the diagnosis of LPP. Read More

    Possible role of Helicobacter pylori in diseases of dermatological interest.
    J Biol Regul Homeost Agents 2017 APR-JUN;31(2 Suppl. 2):57-77
    Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
    Helicobacter pylori is a gram-negative, flagellate, microaerophilic bacterium identified for the first time about 30 years ago, as a pathogenic factor of gastritis and peptic ulcer. Soon after, it was linked to several gastrointestinal and extra-gastrointestinal diseases (hematological, cardiovascular, neurological, pulmonary and ocular diseases, obesity, diabetes mellitus, growth retardation and extragastric MALT lymphoma). Association and possible cause-effect correlation with H. Read More

    Possible triggering factors and comorbidities in newly diagnosed autoimmune bullous diseases.
    Turk J Med Sci 2017 Jun 12;47(3):832-840. Epub 2017 Jun 12.
    Department of Dermatology, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey.
    Background/aim: The distribution and the demographic, etiological, and clinical features of autoimmune bullous diseases (ABDs) vary according to geographic regions of the world. The limited number of reported studies in Turkey are mostly retrospective and generally include only pemphigus. The aim of our study was to evaluate the demographic data, clinical features, associated triggering factors, and comorbidities in patients newly diagnosed with ABDs. Read More

    Association Between Inflammatory Skin Disease and Cardiovascular and Cerebrovascular Co-Morbidities in US Adults: Analysis of Nationwide Inpatient Sample Data.
    Am J Clin Dermatol 2017 Dec;18(6):813-823
    Department of Dermatology, Northwestern University Feinberg School of Medicine, Suite 1600, 676 N. St. Clair St., Chicago, IL, 60611, USA.
    Background: Psoriasis, atopic dermatitis or eczema (AD-E), pemphigus, bullous pemphigoid (BP), and hidradenitis are chronic inflammatory skin disorders associated with systemic immune activation, considerable symptom burden, stigma, functional disturbances, and mental health symptoms. All of these might increase cardiovascular risk.

    Objective: The objective of this study was to determine whether these inflammatory skin diseases are associated with increased cardiovascular/cerebrovascular risk and/or disease. Read More

    Evaluation of prolactin levels in patients with newly diagnosed pemphigus vulgaris and its correlation with pemphigus disease area index.
    Int J Womens Dermatol 2016 Jun 23;2(2):53-55. Epub 2016 Apr 23.
    Department of Dermatology, Tehran University of Medical Sciences, Tehran, Iran.
    Background: Prolactin is a hormone; in addition to it known roles, it has immunomodulatory effects on lymphocytes maturation and immunoglobulins production. Hyperprolactinemia has been demonstrated in various autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, type I diabetes mellitus, and Graves' disease. In view of the prolactin immunomodulatory roles, studying prolactin levels in pemphigus as an autoimmune blistering disease may introduce new ways of understanding disease etiology and developing treatment strategies. Read More

    Increased Risk of Bullous Pemphigoid after First-Ever Stroke: A Population-Based Study.
    Neurodegener Dis 2017 4;17(4-5):166-170. Epub 2017 May 4.
    Department of Neurology, Sijhih Cathay General Hospital, New Taipei City, Taiwan, ROC.
    Background: We hypothesize that autoantibodies are induced after the blood-brain barrier is damaged by stroke and the risk of bullous pemphigoid (BP) is increased after stroke. We assess the risk of BP after first-ever stroke in a nationwide population-based cohort of first-ever stroke patients.

    Methods: We extracted data from the Longitudinal Health Insurance Database 2005 and identified patients with first-ever stroke as well as control patients matched for age, gender, and year of enrollment. Read More

    First-line rituximab combined with short-term prednisone versus prednisone alone for the treatment of pemphigus (Ritux 3): a prospective, multicentre, parallel-group, open-label randomised trial.
    Lancet 2017 May 22;389(10083):2031-2040. Epub 2017 Mar 22.
    Department of Dermatology, Rouen University Hospital and INSERM U1234, Centre de référence des maladies bulleuses autoimmunes, Normandie University, Rouen, France.
    Background: High doses of corticosteroids are considered the standard treatment for pemphigus. Because long-term corticosteroid treatment can cause severe and even life-threatening side-effects in patients with this disease, we assessed whether first-line use of rituximab as adjuvant therapy could improve the proportion of patients achieving complete remission off-therapy, compared with corticosteroid treatment alone, while decreasing treatment side-effects of corticosteroids.

    Methods: We did a prospective, multicentre, parallel-group, open-label, randomised trial in 25 dermatology hospital departments in France (Ritux 3). Read More

    Increased frequency of multiple sclerosis among patients with bullous pemphigoid: a population-based cohort study on comorbidities anchored around the diagnosis of bullous pemphigoid.
    Br J Dermatol 2017 Jun 10;176(6):1486-1491. Epub 2017 Apr 10.
    Department of Dermatology, Aarhus University Hospital, PP Oerumsgade 11, 8000, Aarhus C, Denmark.
    Background: Bullous pemphigoid (BP) is a disease of the elderly and may be associated with neurological and cardiovascular diseases and diabetes. Mortality rates strongly exceed those of the background population.

    Objectives: To investigate the frequency of comorbidities and their temporal relation to BP. Read More

    The Inpatient Burden of Autoimmune Blistering Disease in US Children: Analysis of Nationwide Inpatient Sample Data.
    Am J Clin Dermatol 2017 Apr;18(2):287-297
    Departments of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Suite 1600, 676 N. St. Clair St., Chicago, IL, 60611, USA.
    Background: Little is known about the epidemiology of pediatric autoimmune blistering disorders (PAIBD).

    Objective: We sought to determine the inpatient burden and comorbidities of PAIBD.

    Methods: We analyzed data from the Nationwide Inpatient Sample from 2002 to 2012, which contained a representative 20% sample of all US hospitalizations. Read More

    Common Skin Conditions in Children: Noninfectious Rashes.
    FP Essent 2017 Feb;453:18-25
    University of North Carolina Chapel Hill School of Medicine Dermatology Residency Program, 410 Market St. Suite 400 CB#7715, Chapel Hill, NC 27516.
    Cutaneous adverse drug reactions are among the most common noninfectious rashes of childhood. Cutaneous adverse drug reactions are classified as morbilliform, urticarial, bullous, pustular, or psoriasiform. Atopic dermatitis is one of the most common inflammatory cutaneous eruptions, and is characterized by pruritus and flexural distribution. Read More

    Development of bullous pemphigoid during the haemodialysis of a young man: case report and literature survey.
    Int Wound J 2017 Feb 17;14(1):288-292. Epub 2016 Oct 17.
    Department of Dermatology and Immunodermatology, Medical University of Warsaw, Warsaw, Poland.
    Haemodialysis is the most frequent form of renal replacement therapy (RRT) in patients with end-stage renal disorder (ESRD). Patients with ESRD frequently develop skin problems, mainly xerosis, pruritus and hyperpigmentation, as well as bullous diseases, mainly porphyria or pseudoporphyria and, in some cases, bullous pemphigoid (BP). BP is the most common autoimmune sub-epidermal blistering disease, and it predominantly affects elderly people. Read More

    Three Cases of Bullous Pemphigoid Associated with Dipeptidyl Peptidase-4 Inhibitors - One due to Linagliptin.
    Dermatology 2016 28;232(2):249-53. Epub 2016 Jan 28.
    Department of Dermatology, Hospital Universitario Virgen Macarena, Seville, Spain.
    Background: Bullous pemphigoid (BP) is an acquired subepidermal autoimmune blistering disease in which there are humoral and cellular responses against the BP180 and BP230 antigens. Dipeptidyl peptidase (DPP)-4 inhibitors enhance endogenous glucagon peptide-1 and glucose-dependent insulinotropic polypeptide secretion with food intake, which leads to insulin secretion, as well as to the reduction of glucagon secretion. Recently, several cases of DPP-4 inhibitor-associated BP have been reported. Read More

    Non-O1, non-O139 Vibrio cholerae bacteremic skin and soft tissue infections.
    Infect Dis (Lond) 2016 26;48(3):171-6. Epub 2015 Oct 26.
    c Laboratory of Clinical Bacteriology and Molecular Microbiology , School of Medicine, University of Crete , Heraklion , Crete , Greece.
    Background: Non-O1, non-O139 Vibrio cholerae can cause sporadic cases of gastroenteritis and extra-intestinal invasive infections, following exposure to contaminated seawater or freshwater or after consumption of raw seafood. Bacteremic infections with skin and soft tissue manifestations are uncommon and in most cases are associated with liver cirrhosis, haematologic malignancies, diabetes mellitus and other immunosuppressed conditions.

    Methods: The medical literature was reviewed and we found 47 published cases of non-O1, non-O139 Vibrio cholerae bacteremic skin and soft tissue infections. Read More

    Recurrent rates and risk factors associated with recurrent painful bullous keratopathy after primary phototherapeutic keratectomy.
    Clin Ophthalmol 2015 28;9:1815-9. Epub 2015 Sep 28.
    Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
    Objective: To assess the recurrent rate, mean survival time, and risk factors associated with recurrent painful bullous keratopathy (BK) after primary treatment with phototherapeutic keratectomy.

    Methods: Medical records from 72 patients (72 eyes) who had phototherapeutic keratectomy for painful BK were evaluated. Data for sex, age, duration of BK, associated ocular and systemic diseases (hypertension, diabetes mellitus, ischemic heart disease, asthma, dyslipidemia, and rheumatoid arthritis), frequency and degree of pain (grade 1-3), visual acuity, corneal thickness, intraocular pressure, and laser setting were extracted and analyzed. Read More

    Clinical characteristics of patients with lower limb cellulitis and antibiotic usage in Hospital Kuala Lumpur: a 7-year retrospective study.
    Int J Dermatol 2016 Jan 14;55(1):30-5. Epub 2015 Aug 14.
    Department of Dermatology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia.
    Background: Cellulitis commonly involved lower limbs. This study was carried out to determine the demography, clinical characteristics, risk factors, microbiological aspects, and antibiotics usage in this group of patients in Hospital Kuala Lumpur.

    Methods: A total of one hundred and twenty four patients with lower limb cellulitis treated in the Department of Dermatology, Hospital Kuala Lumpur, between January 2008 and May 2013 were included in this study. Read More

    Survey of bullous pemphigoid disease in northern Iran.
    Int J Dermatol 2015 Nov 17;54(11):1246-9. Epub 2015 Mar 17.
    Department of General Surgery, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
    Background: Bullous pemphigoid is an autoimmune subepidermal blistering skin and mucous membrane disease that usually occurs in elderly people. This study was done to determine clinical features, paraclinical findings, incidence of mucosal lesions, prognosis, course of the disease, and mortality rate of patients with bullous pemphigoid.

    Method: Retrospective descriptive study that reviews the existing files of 122 patients with bullous pemphigoid referred to dermatology clinics of Ghaem and Imam Reza hospitals in Mashhad, Iran, from 1995 to 2010. Read More

    High throughput proteomic analysis and a comparative review identify the nuclear chaperone, Nucleophosmin among the common set of proteins modulated in Chikungunya virus infection.
    J Proteomics 2015 Apr 14;120:126-41. Epub 2015 Mar 14.
    Molecular Virology Laboratory, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram 695014, Kerala, India. Electronic address:
    Unlabelled: Global re-emergence of Chikungunya virus (CHIKV) has renewed the interest in its cellular pathogenesis. We subjected CHIKV-infected Human Embryo Kidney cells (HEK293), a widely used cell-based system for CHIKV infection studies, to a high throughput expression proteomics analysis by Liquid Chromatography-tandem mass spectrometry. A total of 1047 differentially expressed proteins were identified in infected cells, consistently in three biological replicates. Read More

    Positive clinical outcome with IVIg as monotherapy in recurrent pemphigoid gestationis.
    Int Immunopharmacol 2015 May 9;26(1):1-3. Epub 2015 Mar 9.
    Center for Blistering Diseases, 697 Cambridge St, Boston, MA, USA. Electronic address:
    Pemphigoid gestationis (PG) is an autoimmune blistering disease associated with pregnancy. It is characterized by the presence of autoantibodies against bullous pemphigoid antigens in the basement membrane zone. A 32 year old female developed PG in the first pregnancy and had a stillbirth. Read More

    Detection of Type VII Collagen Autoantibodies Before the Onset of Bullous Systemic Lupus Erythematosus.
    JAMA Dermatol 2015 May;151(5):539-43
    Department of Dermatology, University of Texas Southwestern Medical Center, Dallas.
    Importance: Anti-type VII collagen autoantibodies are often detectable in patients with bullous systemic lupus erythematosus (BSLE). However, the timing of their appearance preceding the onset of disease is unknown to date.

    Observations: We report the case of a 50-year-old woman with a history of SLE who was seen with vesicles and bullae around her lips, trunk, axillae, arms, and thighs. Read More

    Association between bullous pemphigoid and neurologic diseases: a case-control study.
    Actas Dermosifiliogr 2014 Nov 5;105(9):860-5. Epub 2014 Jul 5.
    Servicio de Dermatología. Hospital Universitario Reina Sofía, Córdoba, España.
    Introduction: In the past 10 years, bullous pemphigoid has been associated with other comorbidities and neurologic and psychiatric conditions in particular. Case series, small case-control studies, and large population-based studies in different Asian populations, mainland Europe, and the United Kingdom have confirmed this association. However, no data are available for the Spanish population. Read More

    A retrospective consecutive case-series study on the effect of systemic treatment, length of admission time, and co-morbidities in 98 bullous pemphigoid patients admitted to a tertiary centre.
    Acta Derm Venereol 2015 Mar;95(3):307-11
    Department of Dermato-Venereology S, Aarhus University Hospital, P.P. Ørumsgade 11, DK-8000 Aarhus C, Denmark.
    Bullous pemphigoid (BP) is a common blistering disease caused by antibodies directed against hemi-desmosomal proteins BPAG1 and BPAG2. The disease is characterised by intense pruritus and blistering of the skin. The systemic treatment with the highest level of evidence for BP is systemic glucocorticoids. Read More

    Chronic inflammatory disorders and risk of type 2 diabetes mellitus, coronary heart disease, and stroke: a population-based cohort study.
    Circulation 2014 Sep 26;130(10):837-44. Epub 2014 Jun 26.
    From the Department of Primary Care and Public Health Sciences (A.D., M.C.G., J.C.), National Institute for Health Research Biomedical Research Centre at Guy's and St Thomas' National Health Service Foundation Trust (A.D., M.C.G.), and British Heart Foundation Centre (P.C.), King's College London, London, United Kingdom.
    Background: This study sought to evaluate whether risks of diabetes mellitus and cardiovascular disease are elevated across a range of organ-specific and multisystem chronic inflammatory disorders.

    Methods And Results: A matched cohort study was implemented in the UK Clinical Practice Research Datalink including participants with severe psoriasis (5648), mild psoriasis (85 232), bullous skin diseases (4284), ulcerative colitis (12 203), Crohn's disease (7628), inflammatory arthritis (27 358), systemic autoimmune disorders (7472), and systemic vasculitis (6283) and in 373 851 matched controls. The main outcome measures were new diagnoses of type 2 diabetes mellitus, stroke, or coronary heart disease. Read More

    Mortality of patients with bullous pemphigoid in Korea.
    J Am Acad Dermatol 2014 Oct 12;71(4):676-83. Epub 2014 Jun 12.
    Department of Dermatology, Gangnam Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea. Electronic address:
    Background: The reported mortality rates and prognoses of bullous pemphigoid (BP) vary among different countries. However, the mortality rate of BP has not been investigated in Korea.

    Objective: We sought to evaluate the mortality rate of Korean patients with BP in comparison to that of an age-matched general population in Korea, and to identify prognostic factors affecting overall survival. Read More

    Bullous pemphigoid induced by vildagliptin: a report of three cases.
    Fundam Clin Pharmacol 2015 Feb 9;29(1):112-4. Epub 2014 Jun 9.
    Département de Pharmacologie, Faculté de Médecine, Centre Régional de PharmacoVigilance, Centre Hospitalier Universitaire de Lille, Université de Lille 2, 1, place de Verdun, 59037, Lille, France.
    To report three cases of bullous pemphigoid in patients treated with vildagliptin. Case 1: An 86-year-old woman presented with bullous pemphigoid after 1 month of treatment with vildagliptin and metformin. After introduction of clobetasol, the symptoms resolved although vildagliptin was continued. Read More

    Bullous pemphigoid associated with dipeptidyl peptidase IV inhibitors. A case report and review of literature.
    J Dermatol Case Rep 2014 Mar 31;8(1):24-8. Epub 2014 Mar 31.
    Western Michigan University School of Medicine, Dept. of Internal Medicine, 1000 Oakland Drive, Kalamazoo, Michigan 49008-1284, USA;
    Background: Bullous pemphigoid is a cutaneous autoimmune blistering disorder. The etiology for what precipitates this disease is not entirely clear at this point, although it has been associated with certain medications.

    Main Observation: We describe the case of a 70-year-old male with a past medical history of diabetes type 2 who developed a diffuse eruption of bullae with skin biopsy positive for bullous pemphigoid. Read More

    Case for diagnosis: bullosis diabeticorum.
    An Bras Dermatol 2013 Jul-Aug;88(4):652-4
    Pedro Ernesto University Hospital, Rio de Janeiro State University, Rio de Janeiro(RJ), Brazil.
    We present a case of bullosis diabeticorum. It is a rare disorder, probably underdiagnosed, associated with long-term diabetes mellitus. Its etiology remains unclear. Read More

    Review: dermatitis herpetiformis.
    An Bras Dermatol 2013 Jul-Aug;88(4):594-9
    Presidente Prudente Regional Hospital, University of Oeste Paulista, Presidente Prudente(SP),Brazil.
    Dermatitis herpetiformis (DH) or Duhring-Brocq disease is a chronic bullous disease characterized by intense itching and burning sensation in the erythematous papules and urticarial plaques, grouped vesicles with centrifuge growth, and tense blisters. There is an association with the genotypes HLA DR3, HLA DQw2, found in 80-90% of cases. It is an IgA-mediated cutaneous disease, with immunoglobulin A deposits appearing in a granular pattern at the top of the dermal papilla in the sublamina densa area of the basement membrane, which is present both in affected skin and healthy skin. Read More

    Pemphigus vulgaris and infections: a retrospective study on 155 patients.
    Autoimmune Dis 2013 13;2013:834295. Epub 2013 Jun 13.
    Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran 1199663911, Iran ; Department of Dermatology, Tehran University of Medical Sciences, Tehran 1199663911, Iran.
    Background. Autoimmune process and immunosuppressive therapy of pemphigus vulgaris would predispose the patients to infections. Aim. Read More

    Mechanobiological dysregulation of the epidermis and dermis in skin disorders and in degeneration.
    J Cell Mol Med 2013 Jul 15;17(7):817-22. Epub 2013 May 15.
    Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School, Tokyo, Japan.
    During growth and development, the skin expands to cover the growing skeleton and soft tissues by constantly responding to the intrinsic forces of underlying skeletal growth as well as to the extrinsic mechanical forces from body movements and external supports. Mechanical forces can be perceived by two types of skin receptors: (1) cellular mechanoreceptors/mechanosensors, such as the cytoskeleton, cell adhesion molecules and mechanosensitive (MS) ion channels, and (2) sensory nerve fibres that produce the somatic sensation of mechanical force. Skin disorders in which there is an abnormality of collagen [e. Read More

    Increased risk of pemphigoid following scabies: a population-based matched-cohort study.
    J Eur Acad Dermatol Venereol 2014 May 18;28(5):558-64. Epub 2013 Mar 18.
    Division of Urology, Department of Surgery, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
    Background: No prior study has investigated the possibility that scabies patients may be at an increased risk for developing pemphigoid.

    Objective: To evaluate the risk of pemphigoid following scabies during a 3-year follow-up period using a Taiwanese population-based claims database and taking clinical and demographic characteristics into consideration.

    Methods: This investigation consisted of a study group of 6793 subjects with a diagnosis of scabies and 33 965 randomly selected subjects used as a comparison group. Read More

    Treatment and mortality rate of bullous pemphigoid in China: a hospital-based study.
    Eur J Dermatol 2013 Jan-Feb;23(1):94-8
    Department of Dermatology, The First Affiliated Hospital of China Medical University, 155 North Nanjing Street, Shenyang 110001, China.
    Bullous pemphigoid (BP) has been reported to be associated with significant morbidities and a considerable mortality rate. We retrospectively studied 94 patients with BP in a Chinese tertiary medical center between 2005 and 2010 to evaluate the treatment of BP and prognostic factors for the mortality of BP. Cerebrovascular diseases (42. Read More

    Bullosis diabeticorum: is there a correlation between hyperglycemia and this symptomatology?
    Wounds 2012 Dec;24(12):350-5
    Barry University School of Podiatric Medicine and Surgery, Miami Shores, FL.
    Bullosis diabeticorum (bullous disease of diabetes or diabetic bullae) is a noninflammatory, blistering disease occurring spontaneously in diabetic patients.The bullae are usually located on acral skin surfaces, particularly the feet. While this disease is unique to patients with diabetes, it may mimic other blistering disorders. Read More

    Corneal changes in diabetes mellitus.
    Curr Diabetes Rev 2012 Jul;8(4):294-302
    Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Inohana, Chuo-ku, Chiba, Japan.
    Diabetes mellitus is a major disease worldwide, and the prevalence of diabetes has risen significantly in the past several decades. Although one of the major complications of diabetic eyes is diabetic retinopathy (DR), corneal diseases can not only develop in diabetic patients but are also difficult to manage. Diabetic neurotrophic keratopathy is a component of diabetic polyneuropathy and is recognized to be the cause of the morbidity of the cornea in diabetic patients. Read More

    Neurotic excoriations: a diagnosis of exclusion.
    J Clin Aesthet Dermatol 2012 Feb;5(2):63-4
    The Ohio State University Medical Center, Division of Dermatology, Columbus, Ohio.
    Patients with psychiatric disease may use the skin as a means of communication during times of increased emotional distress. Furthermore, a high incidence of skin disorders among patients with a primary psychiatric condition, including depression, schizophrenia, and anxiety, has been demonstrated, with neurotic excoriation being one of the most commonly diagnosed. Despite the strong association and incidence of psychogenic excoriation in patients with a primary psychiatric disorder, it is important for primary care physicians and dermatologists alike to realize that these patients may have true dermatological disease. Read More

    CD8+ T-Cell Deficiency, Epstein-Barr Virus Infection, Vitamin D Deficiency, and Steps to Autoimmunity: A Unifying Hypothesis.
    Autoimmune Dis 2012 24;2012:189096. Epub 2012 Jan 24.
    School of Medicine, The University of Queensland, Brisbane, QLD 4072, Australia.
    CD8+ T-cell deficiency is a feature of many chronic autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, Sjögren's syndrome, systemic sclerosis, dermatomyositis, primary biliary cirrhosis, primary sclerosing cholangitis, ulcerative colitis, Crohn's disease, psoriasis, vitiligo, bullous pemphigoid, alopecia areata, idiopathic dilated cardiomyopathy, type 1 diabetes mellitus, Graves' disease, Hashimoto's thyroiditis, myasthenia gravis, IgA nephropathy, membranous nephropathy, and pernicious anaemia. It also occurs in healthy blood relatives of patients with autoimmune diseases, suggesting it is genetically determined. Here it is proposed that this CD8+ T-cell deficiency underlies the development of chronic autoimmune diseases by impairing CD8+ T-cell control of Epstein-Barr virus (EBV) infection, with the result that EBV-infected autoreactive B cells accumulate in the target organ where they produce pathogenic autoantibodies and provide costimulatory survival signals to autoreactive T cells which would otherwise die in the target organ by activation-induced apoptosis. Read More

    [Neutrophilic dermatosis of the hands].
    Ann Dermatol Venereol 2011 Oct 25;138(10):673-6. Epub 2011 Jun 25.
    Service de dermatologie, hôpital Fournier, CHU de Nancy, France.
    Background: In 1964, based on eight cases, R. Sweet described a form of "acute febrile neutrophilic dermatosis" that was quickly renamed Sweet's syndrome. Over time, other entities (pyoderma gangrenosum, erythema elevatum diutinum, etc. Read More

    Prevalence and clinical features of Thai patients with bullous pemphigoid.
    Asian Pac J Allergy Immunol 2011 Mar;29(1):66-72
    Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Background: Bullous pemphigoid (BP) is a rare, subepidermal autoimmune blistering disease. Studies from different regions show discrepancies in clinical features and courses.

    Objectives: To reveal clinical characteristics, investigations and clinical outcomes of Thai patients with BP and to evaluate the association of BP with malignancy, diabetes mellitus and neurologic diseases. Read More

    Drug-induced bullous pemphigoid in diabetes mellitus patients receiving dipeptidyl peptidase-IV inhibitors plus metformin.
    J Eur Acad Dermatol Venereol 2012 Feb 6;26(2):249-53. Epub 2011 Apr 6.
    Department of Skin & Venereal Diseases, University of Ioannina Medical School and University Hospital of Ioannina, Ioannina, Greece.
    Background: Preclinical data and reports of adverse skin reactions in patients treated with dipeptidyl peptidase-IV inhibitors (gliptins) have increased awareness towards skin-targeting side-effects of these anti-hyperglycaemic drugs. Bullous pemphigoid (BP), sometimes drug-induced, is the most commonly acquired autoimmune blistering dermatosis in western countries, typically a disease of the elderly people with significant morbidity and excess mortality.

    Objective: To report the development of BP in five diabetics under gliptin (4 vildagliptin, 1 sitagliptin) plus metformin in fixed-dose drug combinations. Read More

    Clinical associations with a placental diagnosis of delayed villous maturation: a retrospective study.
    Pediatr Dev Pathol 2011 Jul-Aug;14(4):273-9. Epub 2011 Feb 17.
    School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Ireland.
    Delayed villous maturation (DVM) is a spectrum of placental disease characterized by decreased tertiary villus formation, reduced vasculosyncytial membrane formation, and, in its more severe forms, increased large bullous villi. In some series it has been associated with an increased risk of stillbirth in the late third trimester, but overall there are few data on its significance. The aim of this study was to assess perinatal factors associated with, and the clinical significance of, the finding of DVM on placental histology. Read More

    Increased risk of stroke in patients with bullous pemphigoid: a population-based follow-up study.
    Stroke 2011 Feb 16;42(2):319-23. Epub 2010 Dec 16.
    School of Health Care Administration, Taipei Medical University, Taipei 110, Taiwan.
    Background And Purpose: Although previous research reveals that cardiovascular events and thromboembolic diseases are important causes of death in patients with bullous pemphigoid (BP), the risk of stroke after the diagnosis of BP relative to the general population remains unknown. Using a randomly selected nationwide population-based sample, this study investigates the risk of stroke in patients with BP compared with unaffected individuals of a similar age.

    Methods: This study analyzes data from Taiwan's National Health Insurance Research Database. Read More

    Clinical outcomes and prognostic factors for patients with Vibrio vulnificus infections requiring intensive care: a 10-yr retrospective study.
    Crit Care Med 2010 Oct;38(10):1984-90
    School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
    Objective: Vibrio vulnificus infection is uncommon but potentially life-threatening. The aim of this study was to evaluate clinical outcomes and prognostic factors for patients with V. vulnificus infections admitted to an intensive care unit. Read More

    [Cutaneous infections in bullous pemphigoid patients treated with topical corticosteroids].
    Ann Dermatol Venereol 2010 May 18;137(5):345-51. Epub 2010 Apr 18.
    Service de dermatologie, CHU Henri-Mondor, 51, avenue du Maréchal-De-Lattre-de-Tassigny, 94000 Créteil, France.
    Background: Potent topical corticosteroids (TCS), such as clobetasol propionate are more efficacious than systemic corticosteroids in the treatment of bullous pemphigoid (BP) and in reducing the rate of systemic infectious complications. However, TCS can have cutaneous side effects, such as atrophy and purpura. The risk of cutaneous infections due to TCS in BP is known but has never been studied, despite prolonged use of high doses. Read More

    Bullous pemphigoid and internal diseases - A case-control study.
    Eur J Dermatol 2010 Jan-Feb;20(1):96-101. Epub 2009 Oct 2.
    Ist Department of Dermatovenereology, Masaryk University, St. Anna Faculty Hospital, 656 91, Brno, Czech Republic.
    To study associations of bullous pemphigoid (BP) with internal diseases, we conducted a retrospective case control study assessing the frequency of selected diseases - diabetes mellitus, neurological diseases, malignant tumors, benign prostate hyperplasia, hypertension and ischemic heart disease in patients with BP. 89 patients with BP, whose data were retrieved from the register of the Centre of bullous diseases from the period of 1991-2006, were matched with 89 controls of the same age and gender, recruited from patients treated for other skin diseases. The frequency of internal diseases at the time of the onset of BP was evaluated by unconditional logistic regression adjusted for age and gender and maximum likelihood test for contingency tables. Read More

    Atypical Chikungunya virus infections: clinical manifestations, mortality and risk factors for severe disease during the 2005-2006 outbreak on Réunion.
    Epidemiol Infect 2009 Apr 11;137(4):534-41. Epub 2008 Aug 11.
    Institute de Veille Sanitaire, France.
    In April 2005, an outbreak of Chikungunya fever occurred on the island of Réunion in the Indian Ocean. During winter 2005, six patients developed meningoencephalitis and acute hepatitis due to Chikungunya virus. Our objectives were to determine the incidence and mortality of atypical Chikungunya viral infections and to identify risk factors for severe disease. Read More

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