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    372 results match your criteria Bulletin of the NYU hospital for joint diseases[Journal]

    1 OF 8

    Mosaicplasty for the treatment of the osteochondral lesion in the femoral head.
    Bull NYU Hosp Jt Dis 2012 ;70(4):288-90
    Department of Orthopaedics and Traumatology, Etimesgut Military Hospital, Ankara, Turkey.
    Osteochondral defects of the femoral head are rare and principles of treatment include anatomic reduction, rigid fixation, enhancement of blood supply, and restoration of articular congruity. In this report, we present a case where the defect of the femoral head was treated with surgical dislocation of hip anteriorly and mosaicplasty. At 3-year follow-up, the patient was symptom free with near complete incorporation of the graft radiographically. Read More

    Hibernoma--a case series with multimodality imaging and pathologic correlation.
    Bull NYU Hosp Jt Dis 2012 ;70(4):283-7
    Department of Diagnostic Imaging, The Ottawa Hospital, General Campus-University of Ottawa, 501 Smyth Road, Ottawa, ON, Canada.
    Hibernoma is an uncommon, benign tumor of brown fat origin. The distribution of this tumor originally was described as following the location of persistent brown fat within the subcutaneous tissue of the thorax (especially the periscapular and interscapular regions), neck, axilla, shoulder, and retroperitoneum. Recently, hibernoma was described as being most common in the thigh. Read More

    Progressive migration of broken Kirschner wire into the proximal tibia following tension-band wiring technique of a patellar fracture--case report.
    Bull NYU Hosp Jt Dis 2012 ;70(4):279-82
    Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003, USA.
    Wire breakage and migration is a known complication of using a wire tension band construct to treat displaced patella fractures. We report a case of a broken K-wire that migrated from the patella completely into the proximal tibia without complication 9 years after the index surgery. This report highlights the fact that wire migration can occur long after fracture healing and be relatively asymptomatic. Read More

    Multidrug-resistant Acinetobacter baumannii infection following para-articular steroid injection in the knee--a case report.
    Bull NYU Hosp Jt Dis 2012 ;70(4):276-8
    Department of Orthopaedics and Traumatology, Bone and Joint Infection Unit, Institute of Orthopaedic Surgery Maria Adelaide-AO CTO Maria Adelaide, Turin, Italy.
    Acinetobacter baumannii is an emerging gram-negative nosocomial pathogen that rarely causes infections in orthopaedic patients. We report a case of imipenem-resistant Acinetobacter baumannii paraarticular infection of the knee occurring in a healthy patient following one ambulatory steroid injection for the treatment of quadriceps tendinopathy. The infection was reduced by early surgical debridement of infected tissues, abscess drainage, and prolonged antibiotic therapy with colistin. Read More

    Extensor indicis proprius and extensor digitorum communis rupture after volar locked plating of the distal radius--a case report.
    Bull NYU Hosp Jt Dis 2012 ;70(4):273-5
    Dept. of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003, USA.
    Distal radius fractures are among the most commonly encountered fractures in the extremities. Volar plating of distal radius fracture has gained popularity in recent years with the introduction of the locked plating system. Complications of volar plating include extensor and flexor tendon rupture. Read More

    Bilateral four-part anterior fracture dislocation of the shoulder--a case report and review of literature.
    Bull NYU Hosp Jt Dis 2012 ;70(4):268-72
    Department of Orthopaedics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
    Although bilateral anterior dislocation of shoulder is not that uncommon, there have been only 12 published reports on bilateral anterior fracture dislocation of shoulder. The associated fractures have mostly been greater tuberosity fractures with bilateral three part fractures being reported in only two cases. To our knowledge, a bilateral four part anterior fracture dislocation of the shoulder has not yet been reported in the English literature. Read More

    Adventitial cystic disease of the radial artery--two case reports and a review.
    Bull NYU Hosp Jt Dis 2012 ;70(4):262-7
    Department of Radiology, NYU Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003, USA.
    A 29-year-old female presented with pain and a palpable mass in the left wrist. Imaging demonstrated a multiloculated cystic mass adjacent to the radial aspect of the scaphoid, which was intimately associated with and appeared to arise from the wall of the radial artery and its dorsal branch. The mass was surgically resected. Read More

    Effects of suture tension on the footprint of rotator cuff repairs--technical note.
    Bull NYU Hosp Jt Dis 2012 ;70(4):259-61
    Musculoskeletal Research, NYU Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003, USA.
    The footprint is thought to be an important fact in rotator cuff repairs and has been used to compare various cuff fixation techniques. The following experiment used two different measurement sensors to evaluate the footprint as it is affected by suture tensions in a transosseous equivalent suture bridge repair. It was found that suture tension has a direct effect on footprint contact area and pressure and thus could affect healing and fixation stability and should be characterized in any study of comparative fixation techniques. Read More

    Hospital for joint diseases participates in international spine registry Spine Tango after successful pilot study.
    Bull NYU Hosp Jt Dis 2012 ;70(4):254-8
    Occupationaland Industrial Orthopaedic Center, New York, NY, USA.
    Spine Tango is currently the only international spine registry in existence. It was developed under the auspices of Eurospine, the Spine Society of Europe, and is hosted at the University of Bern, Switzerland. The HJD Spine Center successfully tested Spine Tango during a 3-month pilot study and has since expanded documentation activities to more surgeons. Read More

    Barbed sutures for arthroplasty closure--does it decrease the risk of glove perforation?
    Bull NYU Hosp Jt Dis 2012 ;70(4):250-3
    Division of Adult Reconstruction, Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003, USA.
    Recent resurgence in the interest of barbed suture has extended its application to wound closures in total joint surgery. Improved suture biomaterials and barb geometry has lead to consideration for its use in various orthopedic procedures including arthroplasty. The reported superior wound tensile stress distribution, no need for knots, and ability to close multiple layers with one suture make it an attractive option for deep wound closure after total joint surgery. Read More

    The routine use of tranexamic acid in hip and knee replacements.
    Bull NYU Hosp Jt Dis 2012 ;70(4):246-9
    Department of Trauma and Orthopaedic Surgery, Heatherwood and Wexham Park Hospitals, Wexham, Slough, Berkshire, United Kingdom.
    Purpose: Our aim was to determine whether the administration of intravenous tranexamic acid is a safe and effective means of reducing blood loss associated with hip and knee replacement surgery.

    Method: Sequential cohort study analysing hemoglobin titers, transfusion rates, and the occurrence of venous thromboembolism in patients undergoing hip and knee replacements with and without the administration of tranexamic acid at the time of induction. Finally, a cost benefit analysis was performed. Read More

    Using magnetic resonance imaging to determine preoperative autograft sizes in anterior cruciate ligament reconstruction.
    Bull NYU Hosp Jt Dis 2012 ;70(4):241-5
    Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003, USA.
    Purpose: Accurate prediction of autograft size for anterior cruciate ligament reconstruction can assist in preoperative planning and decision-making regarding graft choices. This study seeks to determine the accuracy of MRI measurements by comparing intraoperative measurements of the patella, semitendinosis, and gracilis tendons while correlating these measurements with patient anthropometric data such as gender, height, and weight.

    Methods: A series of 20 consecutive patients were enrolled who underwent a magnetic resonance imaging study of the knee and proceeded with surgical reconstruction of the anterior cruciate ligament. Read More

    "Incidental" bone lesions--when to refer to the tumor specialist.
    Bull NYU Hosp Jt Dis 2012 ;70(4):235-40
    Department of Orthopaedic Surgery, Naval Hospital Camp Pendleton, Camp Pendleton, CA 92055-5191, USA.
    Incidental bone tumors are, by definition, asymptomatic lesions that are discovered through routine radiographs obtained for other reasons. Generally, these lesions are benign and latent, requiring no further intervention except observation. However, occasionally these radiographs will detect benign aggressive processes or even malignant lesions that do require further treatment and referral to a tumor specialist. Read More

    Congruous versus incongruous patellar tilt--a preliminary study.
    Bull NYU Hosp Jt Dis 2012 ;70(4):232-4
    Mount Sinai Medical Center, 5 East 98th Street, New York, NY 10029, USA.
    Unlabelled: Although the presence of patellar tilt usually implies a tight lateral retinaculum and unhealthy pressure distributions within the patellar cartilage, it is possible for the bony portion of the patella to appear tilted while the articular cartilage is in fact fully congruous in a medial-lateral direction. We call this "congruous tilt." In such cases, a patient may not suffer from an excessive lateral pressure phenomenon, despite the presence of tilt. Read More

    Treatment of long bone nonunions: factors affecting healing.
    Bull NYU Hosp Jt Dis 2012 ;70(4):224-31
    NYU Hospital for Joint Diseases, Department of Orthopaedic Surgery, NYU Langone Medical Center, New York, NY 10003, USA.
    Purpose: Nonunions of the upper and lower extremity have been associated with pain and functional deficits. Recent studies have demonstrated that healing of these nonunions is associated with pain relief and both subjective and objective functional improvement. The purpose of this study was to determine which patient and surgical factors correlated with successful healing of a nonunion following surgical intervention. Read More

    The basic science and clinical applications of osteochondral allografts.
    Bull NYU Hosp Jt Dis 2012 ;70(4):217-23
    Division of Sports Medicine, Rush University Medical Center, Chicago, IL 60612, USA.
    Indications for the use of osteochondral allografts for orthopaedic surgical applications are increasing with improved surgical techniques and advancing experience. Modern tissue banks have developed harvesting, processing, and storage methods that ensure an adequate, safe supply of grafts. Continued research is necessary to find a technique that maximizes chondrocyte viability and metabolism both during storage and implantation. Read More

    Pragmatic and scientific advantages of MDHAQ/ RAPID3 completion by all patients at all visits in routine clinical care.
    Bull NYU Hosp Jt Dis 2012 ;70 Suppl 1:30-6
    Department of Medicine, Division of Rheumatology, NYU Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003, USA.
    The patient history often provides the most important information in diagnosis and management of rheumatoid arthritis (RA) and other rheumatic diseases. A multidimensional health assessment questionnaire (MDHAQ)-with templates to score RAPID3 (routine assessment the patient index data), an index of three patient self-report measures, physical function, pain, and patient global estimate-pro- vides a "scientific" patient history. MDHAQ/RAPID3 scores meet criteria for the scientific method seen for laboratory tests: standard format, quantitative data, protocol for col- lection, and recognition of prognostic implications of levels for management decisions. Read More

    A fresh look at glucocorticoids how to use an old ally more effectively.
    Bull NYU Hosp Jt Dis 2012 ;70 Suppl 1:26-9
    Department of Rheumatology and Clinical Immunology, Charité-Universitätsmedizin Berlin, Campus Mitte, Charitéplatz 1, Berlin, Germany.
    Glucocorticoids form a mainstay of therapy for rheumatoid arthritis (RA) and other conditions since they exert strong anti-inflammatory, immunosuppressive, and disease-modifying therapeutic effects. However, there is increasing awareness of the potential for these drugs to produce adverse effects. Therefore, improvement of the glucocorticoid benefit-risk ratio represents both a current need and an ongoing challenge. Read More

    Short-term and long-term safety of glucocorticoids in rheumatoid arthritis.
    Bull NYU Hosp Jt Dis 2012 ;70 Suppl 1:21-5
    Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, 51020th Street South, Birmingham, AL 35213, USA.
    Despite over 60 years of use, glucocorticoids continue to be a controversial therapy in rheumatoid arthritis (RA). This stems largely from their measured a well as their perceived toxicity. However, a paucity of top tier evidence from clinical trials or very carefully controlled observational studies leads to limited evidence supporting potential causal relations between low-dose glucocorticoids and adverse outcomes. Read More

    Effective initial and long-term prednisone in doses of less than 5 mg/day to treat rheumatoid arthritis--documentation using a patient self-report Multidimensional Health Assessment Questionnaire (MDHAQ).
    Bull NYU Hosp Jt Dis 2012 ;70 Suppl 1:14-20
    Department of Medicine, Division of Rheumatology, New York University School of Medicine and NYU Hospital for Joint Diseases, New York, NY 10003, USA.
    The efficacy of initial and long-term prednisone < 5 mg/ day in treatment of rheumatoid arthritis (RA) by one academic rheumatologist over 25 years from 1980 to 2004 is summarized. Patient responses were assessed using a multidimensional health assessment questionnaire (MDHAQ), completed by all patients at all visits in the infrastructure of care. A database was maintained of all visits, which included medications and scores for physical function, pain, patient global estimate of status, and routine assessment of patient index data (RAPID3), an index of these 3 measures. Read More

    Corticosteroids as disease modifying drugs in rheumatoid arthritis treatment.
    Bull NYU Hosp Jt Dis 2012 ;70 Suppl 1:11-3
    New York University Schoolof Medicine, NYU Hospital for Joint Diseases, 333 East 38th Street,New York, NY 10016, USA.
    The current approach to treatment of RA includes early and aggressive treatment with routine monitoring of outcomes to give patients the best chance of decreasing disease activity as much as possible, with low disease activity and remission being a realistic goal for many patients. In this quest, DMARDs, especially MTX, are the anchor treatment, and low dose prednisone should also be considered in combination with MTX as the best initial choice for RA treatment. Current data suggest that corticosteroids are disease modifying agents that enhance the effects of DMARDs with no real impact on adverse events. Read More

    Rheumatoid arthritis: circadian rhythms in disease activity, signs and symptoms, and rationale for chronotherapy with corticosteroids and other medications.
    Bull NYU Hosp Jt Dis 2012 ;70 Suppl 1:3-10
    Department of Laboratory Medicine and Pathology, University of Minnesota, HealthPartners Institute for Education and Research, Regions Hospital, St. Paul, Minnesota, USA.
    Biological processes and functions at all hierarchical levels are organized in time as biological rhythms of discrete periods. Circadian (24-hour) rhythms, which are of direct importance to clinical medicine, are orchestrated by a set of clock genes of the master brain clock situated in the suprachiasmatic nuclei of the hypothalamus plus numerous subservient peripheral cellular clocks of all tissues and organs. Circadian rhythms are kept in step with the surrounding physical and social milieu by periodic external time cues, the most important one being the 24-hour environmental light-dark cycle. Read More

    Kinase inhibitors for the treatment of rheumatoid arthritis.
    Bull NYU Hosp Jt Dis 2012 ;70(3):204-7
    Seligman Center, Department of Rheumatology and Medicine, NYU Hospital for Joint Diseases, 246 East 20th Street, Suite 101, New York, NY 10003, USA.
    Kinase inhibitors have now been shown to work in various types of patients and have potential to be additional weapons in our armamentarium in rheumatoid arthritis treatment. This review will go over the currently available data and discuss potential uses for these new agents. Read More

    B-cell therapies for rheumatoid arthritis.
    Bull NYU Hosp Jt Dis 2012 ;70(3):200-3
    Division of Rheumatology, Hospital for Joint Diseases, 301 East17th Street, Room 1610, New York, NY 10003, USA.
    B cells were originally considered key mediators in the pathogenesis of rheumatoid arthritis (RA). The presence of these cells in many RA synovial tissues and the discovery of rheumatoid factor had put B cells originally at the center of disease pathogenesis. That enthusiasm vanished shortly thereafter only to resurface in the last 15 years with the appearance of highly specific anti-cyclic citullinated protein antibodies. Read More

    IL-6 inhibition for the treatment of rheumatoid arthritis and other conditions.
    Bull NYU Hosp Jt Dis 2012 ;70(3):195-9
    Northshore University Health System, Evanston, IL, USA.
    New data published or presented in the past year has expanded our understanding of the clinical use of interleukin 6 (IL-6) inhibitors and their role in the management of rheumatoid arthritis (RA) and other rheumatic diseases. Data has become available on the use of tocilizumab (TCZ) in comparison to adalimumab, as therapy in RA patients with an inadequate response to TNF inhibitors and on its role as monotherapy. Early data on the efficacy and safety of subcutaneously administered TCZ suggests a potential role for this formulation of the drug. Read More

    Predictors of response to TNF inhibitors in rheumatoid arthritis - do we have new tools for personalized medicine?
    Bull NYU Hosp Jt Dis 2012 ;70(3):187-90
    School of Medicine, Division of Rheumatology, Etlik, Ankara, Turkey.
    The use of biological agents in the treatment of rheumatoid arthritis (RA) has grown constantly since the approval of the first therapeutic monoclonal antibody against tumor necrosis factor-alpha (TNF) in 1996. While these agents transformed RA treatment, not all patients respond to these agents. Moreover, the cost of these agents is high, and some patients may suffer from adverse events. Read More

    MDHAQ/RAPID3 can provide a roadmap or agenda for all rheumatology visits when the entire MDHAQ is completed at all patient visits and reviewed by the doctor before the encounter.
    Bull NYU Hosp Jt Dis 2012 ;70(3):177-86
    Division of Rheumatology, NYU Hospital for Joint Diseases, 301 East 17th Street, Room 1608, New York, New York 10003, USA.
    The management of rheumatoid arthritis (RA) depends more on the patient history than most other chronic diseases. A patient questionnaire provides a uniform, quantitative, protocolized, "scientific" patient history, with documented prognostic significance for work disability and mortality in RA greater than radiographs and laboratory tests and capacity to distinguish active from control treatment in clinical trials and to monitor clinical care with equivalent or greater significance than joint counts or laboratory tests. Therefore, a "scientific" approach to care of a person with a rheumatic disease involves review of patient function, pain, global status, fatigue, RAPID3, review of systems, self-report joint count, and recent medical history on an MDHAQ before conversation with the patient. Read More

    Update on treatment of psoriatic arthritis.
    Bull NYU Hosp Jt Dis 2012 ;70(3):167-71
    Seattle Rheumatology Associates, 601 Broadway, Suite 600, Seattle, WA 98122, USA.
    Some of this past year's key papers or abstracts on psoriatic arthritis (PsA) assessment and treatment are reviewed in this paper. Treatment begins with identification of the PsA patient. Several screening questionnaires have been developed to be used in dermatology and primary care settings to identify which patients with psoriasis have developed PsA as opposed to other common musculoskeletal problems, such as osteoarthritis and fibromyalgia, thus increasing case-finding and targeting referral. Read More

    Juvenile idiopathic arthritis: an update for the clinician.
    Bull NYU Hosp Jt Dis 2012 ;70(3):152-66
    New York University School of Medicine, Division of Pediatric Rheumatology, New York, NY 10016, USA.
    Juvenile idiopathic arthritis (JIA) comprises a collection of all forms of chronic arthritis in childhood with no apparent cause. JIA is the most common rheumatic disease in children, and may result in significant pain, joint deformity, and growth impairment, with persistence of active arthritis into adulthood. Prior to the mid 1990s, the therapeutic armamentarium for JIA was more limited, utilizing non- specific agents, many with significant adverse effects. Read More

    The year in gout: 2011-2012.
    Bull NYU Hosp Jt Dis 2012 ;70(3):145-51
    Division of Rheumatology, NYU Hospital for Joint Diseases, New York, NY 10003, USA.
    From an epidemiologic view, gout is an increasingly prevalent and increasingly pressing clinical problem. This fact, together with technical advances in biology, pharmacology, and imaging techniques, have led to a decade of increasingly rapid progress in our collective understanding of gout and hyperuricemia. Here we review some of the most important recent advances in gout over the past 12 to 18 months. Read More

    Osteoporosis: an update.
    Bull NYU Hosp Jt Dis 2012 ;70(3):140-4
    NYU Hospital for Joint Diseases, 301 East 17th Street, New York, NY 10003, USA.
    The past year has been a dynamic one for clinicians and researchers with an interest in osteoporosis. This update will focus on the issue of the relationship between bisphosphonate treatment and atypical femoral fractures, highlight the advances in imaging techniques that are increasingly being studied as adjuncts to bone density testing, and explore recent evidence that suggests that osteoporosis medications may be linked to an increase in life expectancy. Since the first case reports describing unusual femur fractures in long term users of bisphosphonates began to appear, there has been great interest in identifying why and whether this class of drug can cause these atypical fractures. Read More

    Fractures of the proximal fifth metatarsal: keeping up with the Joneses.
    Bull NYU Hosp Jt Dis 2012 ;70(1):49-55
    Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases Orthopaedic Institute, New York, New York 11530, USA.
    Fractures of the proximal fifth metatarsal are among the most common fractures of the foot. History, physical examination, and subsequent radiographic work-up can help with the diagnosis of such a fracture. Many fractures of the proximal fifth metatarsal can have an associated prodrome, thereby establishing a level of chronicity to the problem. Read More

    Indications for operative fixation of distal radius fractures: a review of the evidence.
    Bull NYU Hosp Jt Dis 2012 ;70(1):35-40
    Department of Orthopedic Surgery, NYU Hospital for Joint Diseases, New York, New York 98122, USA.
    Operative fixation of distal radius fractures is one of the most commonly performed orthopedic procedures. However, there remains little consensus on the indications for operative versus nonoperative treatment of these injuries. The American Academy of Orthopaedic Surgeons has recently published clinical practice guidelines to help guide management of these injuries. Read More

    Three-and four-part proximal humerus fractures: evolution to operative care.
    Bull NYU Hosp Jt Dis 2012 ;70(1):25-34
    Division of Orthopaedic Surgery, University of Alabama at Birmingham, Birmingham, Alabama 10003, USA.
    The recent increase in life expectancy is expected to bring about a concurrent rise in the number of proximal humerus fractures. Those presenting with significant displacement, osteoporosis, and comminution present distinct clinical challenges, and the optimal treatment of these injuries remains controversial. As implant technologies and treatment strategies continue to evolve, the role and appropriateness of certain operative and nonoperative treatment modalities are being debated. Read More

    Outcomes of interlaminar and transforminal spinal injections.
    Bull NYU Hosp Jt Dis 2012 ;70(1):6-10
    Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, New York, New York 10016, USA.
    Epidural spinal injections can be administered via a translaminar or transforaminal route, depending on the clinical scenario. When it is more desirable to target a specific nerve root, a transforaminal approach is typically used, and when the target is more diffuse, a translaminar method is chosen. Both are commonly used and can be utilized similarly in the lumbar or cervical spine. Read More

    Primary Sjogren's syndrome and autoimmune cytopenias: a relation often overlooked.
    Bull NYU Hosp Jt Dis 2012 ;70(2):130-2
    Division of Rheumatology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
    Primary Sjogren's syndrome is an autoimmune disease wherein there is lymphocytic infiltration of salivary and lacrimal glands. This inflammation is thought to be caused by B-lymphocytes. The most common clinical feature of Sjogren's is dryness of the mouth and eyes, but rare complications can occur such as autoimmune cytopenias. Read More

    Pregnancy in a patient with Wegener's granulomatosis: a case report.
    Bull NYU Hosp Jt Dis 2012 ;70(2):127-9
    Department of Obstetrics and Gynecology, Zeynep Kamil Hospital, Istanbul, Turkey.
    Background: Pregnancy in patients with Wegener's granulamotosis (WG) is rare, and differential diagnosis of WG flare and preeclampsia is difficult.

    Case: A pregnant 35 year old with WG was referred with diagnosis of severe preeclampsia; caesarean section was performed. Intubation of the patient was difficult due to subglottic stenosis. Read More

    Anterior spinal cord syndrome in a patient with Behçet's disease.
    Bull NYU Hosp Jt Dis 2012 ;70(2):120-3
    Division of Rheumatology, Gulhane School of Medicine, Ankara, Turkey.
    Although neurological involvement in Behçet's disease is not so uncommon, isolated spinal cord disease is quite rare and reported to be observed in about 2% of all cases with neurological involvement. Here we report a Behçet's patient with spinal cord disease presented with anterior spinal cord syndrome. This rare syndrome is caused by hypoperfusion of the anterior spinal artery and to our knowledge has not been previously reported in patients with Behçet's disease. Read More

    Focal neurological deficits due to a contrast enhancing lesion in a patient with systemic lupus erythematosus: case report and review of literature.
    Bull NYU Hosp Jt Dis 2012 ;70(2):115-9
    New York University Hospital for Joint Diseases, Seligman Center for Advanced Therapeutics, New York, New York 10003, USA.
    Neuropsychiatric (NP) systemic lupus erythematosus (SLE) is a complex entity comprising 19 different discrete syndromes. We report a case of a 32-year-old female with SLE and new onset neurological symptoms and radiographic evidence of a contrast enhancing lesion on brain MRI. The lesion was successfully excised and found to be granulomatous in nature. Read More

    Rheumatology and oncology: an updated review of rheumatic manifestations of malignancy and anti-neoplastictherapy.
    Bull NYU Hosp Jt Dis 2012 ;70(2):109-14
    Department of Rheumatology, University of South Florida, Tampa, Florida 33612, USA.
    Objective: Review of the literature addressing the rheumatic manifestations of various malignancies as well as of common chemotherapeutic agents.

    Methods: A literature search was performed to identify key articles regarding the association of rheumatic disease with malignancy.

    Results: Our review focused on the association of rheumatic disease with malignancy, paraneoplastic syndromes with rheumatic manifestations, and chemotherapeutic agents related to rheumatic syndromes. Read More

    Activation of diverse eicosanoid pathways in osteoarthritic cartilage: a lipidomic and genomic analysis.
    Bull NYU Hosp Jt Dis 2012 ;70(2):99-108
    Division of Rheumatology, New York University School of Medicine, New York, New York 10003, USA.
    Objective: Non-steroidal anti-inflammatory drugs (NSAIDs) that are prescribed for treatment of osteoarthritis (OA) symptoms including pain and inflammation target the production eicosanoids which exhibit numerous functions in various cell types. In these studies, we have (a) identified the diverse eicosanoid pathways that are activated in human chondrocytes of normal and OA cartilage, (b) delineated the modulation of eicosanoids in the presence of NSAIDS and selective COX-2 inhibitors, and (c) characterized eicosanoid products and various transcripts modulated by various inhibitors of eicosanoids in human OA cartilage by gene expression arrays.

    Methods: Immunoassay analysis of culture supernatants were utilized to determine the spectrum of eicosanoids derived from both the cyclooxygenase (COX) and lipoxygenase (LOX) pathways of normal and human OA cartilage in ex-vivo conditions. Read More

    An evidence-based medical visit for patients with rheumatoid arthritis based on standard, quantitative scientific data from a patient MDHAQ and physician report.
    Bull NYU Hosp Jt Dis 2012 ;70(2):73-94
    Department of Medicine, Division of Rheumatology, New York University School of Medicine, New York, New York 100003, USA.
    An evidence-based visit is described based on quantitative, standard scientific data on two simple forms for a patient and a physician. The focus is rheumatoid arthritis (RA), but the principles may be applied to most rheumatic and chronic diseases. A quantitative patient history is recorded on a selfreport multidimensional health assessment questionnaire (MDHAQ), which includes scales for physical function, pain, patient global estimate, psychological distress, change in status, exercise status, morning stiffness, fatigue, and a template to score RAPID3 (routine assessment of patient index data 3). Read More

    Longitudinal studies in rheumatology: some guidance for analysis.
    Bull NYU Hosp Jt Dis 2012 ;70(2):65-72
    Department of Biostatistics, Erasmus MC, Rotterdam, The Netherlands.
    In a follow-up study, patients are monitored over time. Longitudinal and time-to-event studies are the two most important types of a follow-up study. In this paper, the focus is on longitudinal studies with a continuous response where patients are examined at several time points. Read More

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