6,511 results match your criteria Bulletin de l'Academie nationale de medecine[Journal]


Le cancer chez les déficients intellectuels: épidémiologie et prise en charge.

Bull Acad Natl Med 2016 03;200(3):589-96

In France, people with intellectual disability (ID) account approximately for 2.5 % of the total population. Life expectancy of ID increased over the last years, and this raised the risk of cancers developing in this group of patients. Read More

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March 2016
13 Reads

[SPA therapy for pain of patients with chronic low back pain, knee osteo-arthritis and fibromyalgia].

Bull Acad Natl Med 2016 03;200(3):575-86; discussion 586-7

The data of 33 randomized controlled trials suggest that chronic pain of patients with chronic low back pain, knee osteo-arthritis, fibromyalgia is significantly improved by balneotherapy and significantly better improved than by control treatments. For chronic low back pain (10 RCT, 1192 patients) pain was better improved in balneotherapy group and the weighted mean of the differential improvement was 19.66 (95 % CI: 16. Read More

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March 2016
7 Reads

[Innate Lymphoid Cells: new actors of immunity].

Bull Acad Natl Med 2016 03;200(3):561-72; discussion 573-4

The world of lymphocytes has recently expanded. A new group of cells, innate lymphoid cells (ILCs) has been defined. It includes lymphoid cells that have been known for decades, such as natural killer (NK) cells, and lymphoid tissue--inducer (LTi) cells. Read More

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March 2016
5 Reads

[Innovative immunotherapies of respiratory allergic diseases].

Bull Acad Natl Med 2016 03;200(3):545-7; discussion 557-9

Allergen immunotherapy (AIT) is an effective method in the treatment of respiratory allergic diseases (asthma, rhinitis and conjunctivitis). In addition to reducing symptoms, AIT can alter the course of allergic disease and remains efficient long after it has been discontinued by inducing specific tolerance to the allergen. In current clinical practice, immunotherapy is administered by subcutaneous or sublingual routes. Read More

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March 2016
13 Reads

Chirurgie aortique totalement laparoscopique ou par laparotomie: comparaison des résultats après appariement par un score de propension.

Bull Acad Natl Med 2016 03;200(3):527-40; discussion 540-3

Study Objective: To compare the postoperative and medium-term outcomes of laparoscopic aortic surgery with those of conventional aortic surgery performed by a surgical team trained in laparoscopic aortic surgery.

Methods: A prospective study was conducted between January 2006 and December 2011 with 228 consecutive patients having undergone aortic bypass surgery for either an abdominal aortic aneurysm (n = 139) or an occlusive aortoiliac disease (n = 89). Conventional open aortic surgery was carried out in 145 patients, and total laparoscopic repair in 83 patients. Read More

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March 2016
7 Reads

[DNA Ancestry and phenotype markers analyses and French law].

Authors:
Bertrand Ludes

Bull Acad Natl Med 2016 03;200(3):515-25; discussion 525-6

Since some of the genetic markers involved in the analyses are single nucleotide polymorphisms located in protein-coding regions or exons, their analyses are today forbidden for forensic application in French law. A recent application of the French Criminal Chamber of "Cour de Cassation" indicates that it would be possible to perform phenotypic studies and Ancestry Informative Markers (AIM) analysis on stain samples but not on samples taken from a body. The authors present the results of the HIrisplex test performed on seven bone samples belonging to a Mongolian Altaï population dated from the late Bronze Age. Read More

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March 2016
5 Reads

[Angioplasty, coronarography and coronary artery bypass in France: a geographical approach].

Bull Acad Natl Med 2016 03;200(3):497-512; discussion 512-3

There are major geographic disparities in the practice of coronary angioplasty and coronarography in France. Their study shows that the frequency of these procedures is linked to the density of private medical practice (cardiologist's offices or clinics). This is not observed as far as coronary artery bypass surgery is concerned. Read More

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March 2016
5 Reads

Élimination du paludisme, un objectif envisageable? Coordonner les actions.

Bull Acad Natl Med 2016 03;200(3):493-5

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March 2016
14 Reads

[CONCLUSIONS].

Authors:
Sophie Allauzen

Bull Acad Natl Med 2016 03;200(3):491-2

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March 2016
5 Reads

[Plasmodium falciparum resistance to artemisinin-based combination therapies (ACTs): Fears of widespread drug resistance].

Bull Acad Natl Med 2016 03;200(3):477-89; discussion 490

Malaria treatment with ACTs (Artemisinin-based Combination Therapies), combining a chemical derivative of artemisinin, and a partner drug has, for more than 15 years, produced a notable decrease in the mortality in tropical and subtropical areas. However, since 2008, a serious threat has emerged in western Cambodia, where the clinical efficacy of artemisinins has significantly declined, with a delayed parasite clearance rate and high recrudescence rates in the following weeks. Resistance of Plasmodium to artemisinins is now reported in several countries in South-East Asia. Read More

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March 2016
6 Reads

[Elimination in South-East Asia? The role of antimalarial drugs].

Authors:
François Nosten

Bull Acad Natl Med 2016 03;200(3):467-75; discussion 475-6

Artemisinin resistance in P. falciparum is spreading in South East Asia and threatens the recent progresses made in the fight against malaria. A race against time has started to eliminate P. Read More

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March 2016
5 Reads

[Malaria is still a leading cause of fever and death among children and pregnant women in Africa in 2015].

Bull Acad Natl Med 2016 03;200(3):453-66

The prevalence and morbidity of P. vivax, P. ovale (curisi et wallikeri) and P. Read More

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March 2016
23 Reads

[Towards a neuropsychological approach to autism]

Authors:
Jean Cambier

Bull Acad Natl Med 2016 03;200(3):435-45

Neuropsychology attributes mental activity to brain functioning. An inventory of the every-day life of the autist confirms a breakdown in behavior adapted to the world around him. Deficiency in the contribution of the right hemisphere, compromising social life, is accompanied by a mental life that is detached from reality, favorizing preconceived ideas that are inscribed in the logic governing the left hemispheric function. Read More

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March 2016
4 Reads

[Is autism a different kind of intelligence? New insights from cognitive neurosciences].

Authors:
Laurent Mottron

Bull Acad Natl Med 2016 03;200(3):423-34; discussion 433-4

After being considered a mental disorder for years, then a neurodevelopmental handicap, autism is increasingly being considered a human variant that sometimes involves extreme adaptive advantages and disadvantages. This point of view partly emerges from the fact that autistics perform certain human tasks at the same level, and in some cases even better than neurotypical persons. Furthermore, they perform these tasks using cognitive strategies and cerebral allocations that are different from the majority of humans. Read More

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March 2016
6 Reads

[Early detection of autism spectrum disorders: emerging symptoms and biomarkers].

Bull Acad Natl Med 2016 03;200(3):415-22

Early recognition of Autism Spectrum Disorders (ASD) in patients before the age of 24 months significantly enhances the prognosis of affected children. That's why researchers try to identify behavioral and/or neurophysiological precursors in the first months of life of children. Prospective studies are specifically performed in infant siblings at risk of ASD. Read More

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March 2016
5 Reads

Rare microcytic anemias.

Bull Acad Natl Med 2016 Feb;200(2):335-347

Microcytic anemia is often due to disorder of globin genes. Here, we focus on rare monogenic microcytic anemias, We describe the diferent congenital forms that are due to mutations in genes implicated in iron homeostasis, the heme biosynthesis pathway, the cluster Fe-S biosynthesis pathway andmitochondrial proteins biosynthesis pathway. Among rare congenital microcytic anemias, most frequent forms are non syndromic sideroblastic anemias and iron refractory iron deficiency anemias (IRIDA). Read More

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February 2016
3 Reads

Dysmetabolic iron overload syndrome.

Bull Acad Natl Med 2016 Feb;200(2):327-333

Mild hyperferritinemia is frequent in patients with metabolic syndrome. When exceeding 500 pg/l, it usually accounts for real iron excess and is coined as dysmetabolic iron overload syndrome (DIOS). The diagnosis of DIOS is mainly made in middle-aged males. Read More

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February 2016
2 Reads

Hemocromatosis: a changing world.

Authors:
Pierre Brissot

Bull Acad Natl Med 2016 Feb;200(2):309-325

Due to major advances in the understanding of iron metabolism as well as in the bioche- iuical, imaging, and genetic domains: i) The nosologicalframework of hemochromatosis (HC) encompasses not only HFE-HC, by far the most frequent HC form, but also non-HFE HC diseases which comprise essentially juvenile HC and the ferroportin disease. ii) The diagnostic approach has become totally non invasive, based on clinical, imaging and biological data. iii) The treatment remains, for most forms, based on venesections, but the innovative emerging therapeutic approach is represented by hepcidin supplementation. Read More

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February 2016
1 Read

[Not Available].

Authors:
Catherine Buffet

Bull Acad Natl Med 2016 Feb;200(2):307-308

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February 2016
2 Reads

Prosthesis joint infections: contributions of experimental models to understanding the limitations of antibiotic efficacy and optimization of medical treatment.

Bull Acad Natl Med 2016 Feb;200(2):291-305

Post-operative infection remains the main complication of prosthetic joint replacement, since its inception by Robert and Jean Judet in 1947. Because the number ofjoint prostheses implanted annually is increasing substantially, these infections are becoming more-and- more common and optimizing their management is an important issue for medical and economic reasons. Prosthetic joint infections are a good model for understanding the limitations of in vivo antibiotic eficacy. Read More

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February 2016
15 Reads

[Not Available].

Authors:
Yvon Lebranchu

Bull Acad Natl Med 2016 Feb;200(2):285-290

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February 2016
2 Reads

[Not Available].

Authors:

Bull Acad Natl Med 2016 Feb;200(2):261-284

Since 1978, the Bone Tissue Bank of Marseille has, stored 11 762 bone or osteochondral bones pieces. 758 were massive Allografts (745 has been used). These grafts stored in liquid nitrogen (at -196 C), with a cryo-preservator (DMSO) have not been secondary sterilized by irradiation. Read More

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February 2016
3 Reads

[Not Available].

Bull Acad Natl Med 2016 Feb;200(2):253-260

Bone allografts remain irreplaceable whether it be a question of offsetting high bone decay or oncologic surgery that could not be filled by an autograft. To meet the needs of patients, a network has been organized. It includes hospital coordina- tors, the Biomedicine Agency, surgical teams, healthcare establishments, and tissue banks. Read More

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February 2016
2 Reads

[Not Available].

Bull Acad Natl Med 2016 Feb;200(2):251-252

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February 2016
3 Reads

Which pharmacovigilance for vaccines?

Bull Acad Natl Med 2016 Feb;200(2):241-250

Vaccines are drugs. Like all medicines, they are submitted to pre-clinical tests and then clinical trials. These tests and trials are essential but unfortunately insufficient because, for example, they are necessarily too short, they include too few subjects not representative of future treated patients. Read More

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February 2016
23 Reads

[Not Available].

Bull Acad Natl Med 2016 Feb;200(2):233-240

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February 2016
2 Reads

Estimation of the epidemiological impact of sub-optimal vaccination coverage in France.

Authors:

Bull Acad Natl Med 2016 Feb;200(2):219-231

Vaccination coverage is insuficient for many vaccines in France. We estimated from available epidemiological data, the number of cases, deaths or hospitalizations that occur- red while they could have been avoided by achieving the expected coverage levels. Non prevented mortality is especially important for influenza. Read More

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February 2016
2 Reads

[Not Available].

Bull Acad Natl Med 2016 Feb;200(2):211-217

Under diverse pretexts the vaccination sees itself controversial in particular in France, and it in a increasing way. This establishes a real problem of public health. The doubt which settles down in the population becomes source of grave potential risk in the fight against the infectious diseases. Read More

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February 2016
2 Reads

Vaccine hesitancy: some insights from social and psycho- logical sciences.

Authors:
Jocelyn Raude

Bull Acad Natl Med 2016 Feb;200(2):199-209

In the last few years, vaccine hesitancy has considerably grown in the populations of western countries, particularly since controversies about the utility and safety of vaccines and their adjuvants recently multiplied. After a critical examination of the concept of " vaccine hesitancy "as well as its expressions through history, we will address the main psychological and sociological processes that could help us to better understand its development in modern societies. On the one hand, the evidence drawn from the existing literature shows that vaccine hesitancy typically derives from an intuitive trade-off between the perceived risks and benefits from the vaccination. Read More

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February 2016
7 Reads

Management of bacterial menigitis in 2016.

Authors:
Etienne Javouhey

Bull Acad Natl Med 2016 Jan;200(1):99-111

Bacterial meningitis is a severe infection of the central nervous system with significant impact on survival and functional outcome. Complications are related to the release of bacterial components in the subarachnoid space closed to the brain. Three types of complications are distinguished: septic shock that alters the oxygen delivery, intracranial hypertension (ICH) that may alter the cerebralperfusion pressure and severe metabolic disorders like hyponatremia. Read More

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January 2016
11 Reads

Mother to child HIV transmission.

Authors:
Stephane Blanche

Bull Acad Natl Med 2016 Jan;200(1):91-97

Thirty years after the first descriptions of AIDS in children in 1983, the risk of viral transmission from mother to child has been reduced to almost zero, thanks to antiretroviral drugs during pregnongh. This extraordinary prophylactic efficacy progressively spread to poor countries with high prevalence. The hope of a virtual eradication of HIV transmission appears as a "feasible utopia". Read More

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January 2016
2 Reads

What is new in neonatal infection?

Bull Acad Natl Med 2016 Jan;200(1):81-90

Diagnostic of early neonatal infection remains a serious challenge. Since clinical symptoms and biological markers are neither sensitive nor specific, a lot of newborns suspected of infection, undergo biological analysis and empirical antibiotic treatment awaiting bacteriological results. However the prevalence of the disease has dramatically decreased since the last twenty years, subsequently to the generalization of the per partum antibioprophylaxis strategy. Read More

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January 2016
1 Read

Links between genetics and immunology: mutations and antigens.

Authors:
Maha Ayyoub

Bull Acad Natl Med 2016 Jan;200(1):67-79

Recent advances in cancer immunotherapy by immune checkpoint blockade are emphasizing the importance of Tcell responses to tumors in disease control. In addition, the development of next generation DNA sequencing technologies combined to reverse immunology approaches facilitate the appreciation of the involvement of T cell responses to neoantigens, which result from tumor-specific genomic alterations, in the immune response to tumors. Neoantigens extend the categories of previously characterized tumor antigens and, together with the latter, offer opportunities to target large proportions of tumors by passive and active specific immunotherapy approaches. Read More

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January 2016
2 Reads

Vaccine prospects against hepatitis C.

Bull Acad Natl Med 2016 Jan;200(1):59-65

The hepatitis C virus induces chronic liver diseases leading to cirrhosis and cancer. New antiviral drugs are now available to eliminate efficiently the infection with this virus. However, these drugs are very expensive, and many subjects are unaware of their infection status until the disease breaks out. Read More

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January 2016
1 Read

[Not Available].

Bull Acad Natl Med 2016 Jan;200(1):47-58

In twenty years, significant progress was made in the knowledge of viral hepatitis. Alphabet of hepatotropic viruses has extended, and C, D, E and G viruses have been added to hepatitis A and B viruses; their genomes have been characterized, allowing defining various types, subtypes and isolates with different pathological and therapeutic implications. Our knowledge regarding the epidemiology, virology and treatment of viral hepatitis is in constant evolution, allowing a better diagnostic and therapeutic approach of patients with acute and chronic hepatitis. Read More

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January 2016
4 Reads

Hepatitis B vaccination: evolution of hepatitis B vaccine coverage; public health impact, efficiency limits, New vaccines.

Authors:
Frangois Denis

Bull Acad Natl Med 2016 Jan;200(1):33-45

With a prevalence of HBs antigen carriage of 0.65 %, France belongs to low endemic countries for hepatitis B virus (HB V) infection. HBV attributable mortality is estimated to be 2. Read More

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January 2016
1 Read

[Not Available].

Authors:
Yves Buisson

Bull Acad Natl Med 2016 Jan;200(1):29-31

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January 2016
2 Reads

Spinal cord injury. From the proof of principle to the therapeutic tool.

Authors:
Alain Privat

Bull Acad Natl Med 2016 Jan;200(1):19-28

Spinal cord injury is a devastating pathology with heavy social and personal sequels,. Therapeutic strategies are organized around three research directions: Neuroprotection, axonal regeneration and substitutive therapies. Of particular interest is axonal regeneration. Read More

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January 2016
1 Read

[Not Available].

Bull Acad Natl Med 2015 11;199(8-9):1395-1407

Refractory thyroid cancers are cancers that cannot be cured with current therapy. They include advanced forms offollicular cell derived well-diferentiated thyroid cancer that are not amenable to radioactive iodine treatment (4 to 5 cases per million population per year), advanced forms of medullary thyroid cancer (1 case per 1-2 million population per year) and all anaplastic cancers (1 case per million population per year). They are rare, but are responsible for the majority of the 400 thyroid cancer related deaths that occur each year in France. Read More

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November 2015
3 Reads

[Post-infarct cardiac remodelling: A problem in quest of prevention and therapy].

Bull Acad Natl Med 2015 11;199(8-9):1383-1394

Cardiac remodelling (REM) is the most important cause of heart failure after myocardial itifarct. It is characterised by cardiac dilation and an evolution towards the fetal phenotype and myocardial fibrosis. The " primum movens " is cardiac cell death caused by necrosis andlor apoptosis. Read More

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November 2015
1 Read

[Surgery for chronic low back pain: good option? Better than conservative treatment?]

Bull Acad Natl Med 2015 11;199(8-9):1367-1382

The goal of this article is to assess, using the literature and our own experience, whether surgery is a reasonable option in the management of non-specific or degenerative chronic low back pain. The usual starting points for low back pain are without doubt the intervertebral disc and the facet joints, but the actual etiology is often difficult to determine. Moreover, psychogenic factors may amplify clinical symptoms. Read More

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November 2015
2 Reads

[Not Available].

Bull Acad Natl Med 2015 11;199(8-9):1345-1365

Chronic low back pain is extremelyfrequent and its management is still con troversial among spine physicians. For decades, intervertebral fusion has been considered as the gold- standard. However, non fusion techniques have been developed in order to avoid fusion's complications. Read More

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November 2015
3 Reads

[Biomechanics of the lumbar intervertebral disc].

Bull Acad Natl Med 2015 11;199(8-9):1335-1343

The intervertebral disc is at the center of the functioning of the human being Its biomecha- nical functions are very complex and their degradation may cause major issues for the patient. We present here a synthesis of the state of the art regarding the biomechanics of the lumbar disc as prospects of research and clinical applications coming from recent research done at the Institut de Biom6canique Humaine Georges Charpak. Read More

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November 2015
3 Reads

[Not Available].

Authors:
Khé Hoang-Xuan

Bull Acad Natl Med 2015 11;199(8-9):1331

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November 2015
2 Reads

[Targeted therapy in glioblastoma: update and perspectives].

Bull Acad Natl Med 2015 11;199(8-9):1323-1329

Glioblastoma is the most common primary malignant brain tumor in adults. Despite very intensive treatments (i.e. Read More

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November 2015
2 Reads

[Laser and Ultrasound brain tumor therapy: from the present to the future of neurosurgery].

Bull Acad Natl Med 2015 11;199(8-9):1307-1321

Brain tumors require first a surgical treatment or a biopsy procedure for deep-seated lesions. In partnership with physicists, we developed stereotactic Laser and Ultrasound probes to realize minimal invasive treatments under real time MRI guidance and local anesthesia. Our first clinical trial was performed in 2008 with a Laser probe. Read More

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November 2015
2 Reads

[Role of community pharmacists in obesity prevention and support to patients].

Bull Acad Natl Med 2015 11;199(8-9):1291-1303

Prevention, health education and patient education are among the community pharmacists' missions. Through their access to patients, community pharmacists have an important role to play in tackling obesity: they contribute to public information and awareness, they promote obesity prevention by helping people improve diet and physical activity, they identify and refer patients to GPs for monitored weight loss programmes and provide daily support to patients with obesity. Health and social education committee for French pharmacy (Cespharm) - a special unit of the French pharmaceutical Chamber - helps pharmacists to get involved in these fields. Read More

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November 2015
1 Read

[Early determinants of obesity].

Bull Acad Natl Med 2015 11;199(8-9):1281-1289

The prevalence of childhood obesity has increased dramatically in the second half of the 20th century even in children before the age of 5 years. Many factors may interfere with early development, from the prenatal period to the first two years of life, and modulate susceptibility to subsequent obesity. Regarding the prenatal period, maternal BMI before pregnancy is a factor associated with adult obesity in a very reproducible way. Read More

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November 2015
1 Read