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    6444 results match your criteria Bulletin de l'Academie nationale de medecine[Journal]

    1 OF 129

    [SPA therapy for pain of patients with chronic low back pain, knee osteo-arthritis and fibromyalgia].
    Bull Acad Natl Med 2016 03;200(3):575-86; discussion 586-7
    The data of 33 randomized controlled trials suggest that chronic pain of patients with chronic low back pain, knee osteo-arthritis, fibromyalgia is significantly improved by balneotherapy and significantly better improved than by control treatments. For chronic low back pain (10 RCT, 1192 patients) pain was better improved in balneotherapy group and the weighted mean of the differential improvement was 19.66 (95 % CI: 16. Read More

    [Innovative immunotherapies of respiratory allergic diseases].
    Bull Acad Natl Med 2016 03;200(3):545-7; discussion 557-9
    Allergen immunotherapy (AIT) is an effective method in the treatment of respiratory allergic diseases (asthma, rhinitis and conjunctivitis). In addition to reducing symptoms, AIT can alter the course of allergic disease and remains efficient long after it has been discontinued by inducing specific tolerance to the allergen. In current clinical practice, immunotherapy is administered by subcutaneous or sublingual routes. Read More

    Bull Acad Natl Med 2016 03;200(3):527-40; discussion 540-3
    Study Objective: To compare the postoperative and medium-term outcomes of laparoscopic aortic surgery with those of conventional aortic surgery performed by a surgical team trained in laparoscopic aortic surgery.

    Methods: A prospective study was conducted between January 2006 and December 2011 with 228 consecutive patients having undergone aortic bypass surgery for either an abdominal aortic aneurysm (n = 139) or an occlusive aortoiliac disease (n = 89). Conventional open aortic surgery was carried out in 145 patients, and total laparoscopic repair in 83 patients. Read More

    [DNA Ancestry and phenotype markers analyses and French law].
    Bull Acad Natl Med 2016 03;200(3):515-25; discussion 525-6
    Since some of the genetic markers involved in the analyses are single nucleotide polymorphisms located in protein-coding regions or exons, their analyses are today forbidden for forensic application in French law. A recent application of the French Criminal Chamber of "Cour de Cassation" indicates that it would be possible to perform phenotypic studies and Ancestry Informative Markers (AIM) analysis on stain samples but not on samples taken from a body. The authors present the results of the HIrisplex test performed on seven bone samples belonging to a Mongolian Altaï population dated from the late Bronze Age. Read More

    [Angioplasty, coronarography and coronary artery bypass in France: a geographical approach].
    Bull Acad Natl Med 2016 03;200(3):497-512; discussion 512-3
    There are major geographic disparities in the practice of coronary angioplasty and coronarography in France. Their study shows that the frequency of these procedures is linked to the density of private medical practice (cardiologist's offices or clinics). This is not observed as far as coronary artery bypass surgery is concerned. Read More

    [Plasmodium falciparum resistance to artemisinin-based combination therapies (ACTs): Fears of widespread drug resistance].
    Bull Acad Natl Med 2016 03;200(3):477-89; discussion 490
    Malaria treatment with ACTs (Artemisinin-based Combination Therapies), combining a chemical derivative of artemisinin, and a partner drug has, for more than 15 years, produced a notable decrease in the mortality in tropical and subtropical areas. However, since 2008, a serious threat has emerged in western Cambodia, where the clinical efficacy of artemisinins has significantly declined, with a delayed parasite clearance rate and high recrudescence rates in the following weeks. Resistance of Plasmodium to artemisinins is now reported in several countries in South-East Asia. Read More

    [Towards a neuropsychological approach to autism]
    Bull Acad Natl Med 2016 03;200(3):435-45
    Neuropsychology attributes mental activity to brain functioning. An inventory of the every-day life of the autist confirms a breakdown in behavior adapted to the world around him. Deficiency in the contribution of the right hemisphere, compromising social life, is accompanied by a mental life that is detached from reality, favorizing preconceived ideas that are inscribed in the logic governing the left hemispheric function. Read More

    [Is autism a different kind of intelligence? New insights from cognitive neurosciences].
    Bull Acad Natl Med 2016 03;200(3):423-34; discussion 433-4
    After being considered a mental disorder for years, then a neurodevelopmental handicap, autism is increasingly being considered a human variant that sometimes involves extreme adaptive advantages and disadvantages. This point of view partly emerges from the fact that autistics perform certain human tasks at the same level, and in some cases even better than neurotypical persons. Furthermore, they perform these tasks using cognitive strategies and cerebral allocations that are different from the majority of humans. Read More

    [Early detection of autism spectrum disorders: emerging symptoms and biomarkers].
    Bull Acad Natl Med 2016 03;200(3):415-22
    Early recognition of Autism Spectrum Disorders (ASD) in patients before the age of 24 months significantly enhances the prognosis of affected children. That's why researchers try to identify behavioral and/or neurophysiological precursors in the first months of life of children. Prospective studies are specifically performed in infant siblings at risk of ASD. Read More

    [Issues surrounding the preservation and subsequent use of transsexual persons' gametes].
    Bull Acad Natl Med 2014 Mar;198(3):613-31
    Some transsexual persons wish to have their gametes frozen before gender transition, in order to preserve their fertility. This measure should be carried out, in strict compliance with the law, in case of orchidectomy, oophorectomy or hysterectomy However, as hormonal treatments do not irreversibly alter gonadal function, the reproductive capacity of trans-sexual persons can be maintained by avoiding surgical sterilization. There is therefore no obvious medical indication for cryopreserving gametes or germinal tissue in the absence of surgical sterilization. Read More

    [Cannabis use among children and adolescents: impacts and consequences].
    Bull Acad Natl Med 2014 Mar;198(3):579-88
    A health policy for the prevention and treatment of cannabis-related disorders is urgently needed in France, given the high prevalence of cannabis use among children and adolescents. Such a policy will require a better understanding of the endo-cannabinoid system and the impact of exogenous cannabinoids in this fragile population. The brain continues to undergo significant development until the age of about 25 years, and cannabis consumption by young people therefore carries specific risks of dependence (frequency and intensity), and of neuroanatomical, cognitive and emotional damage. Read More

    [Cannabis-induced cognitive and psychiatric disorders].
    Bull Acad Natl Med 2014 Mar;198(3):559-74; discussion 575-7
    Several studies have shown that Δ-9-THC the main psychoactive constituent of cannabis, can impair cognitive functions, especially attention, episodic memory, working memory and executive functions. These impairments have been related to the duration, frequency, dose and age at onset of cannabis use. Cognitive deficits may disappear with abstinence, but abnormalities may be long-lasting in subjects who began smoking cannabis before age 15. Read More

    [Tetrahydrocannabinol pharmacokinetics; new synthetic cannabinoids; road safety and cannabis].
    Bull Acad Natl Med 2014 Mar;198(3):541-56; discussion 556-7
    Delta-9-tetrahydrocannabinol (THC) is the main psychoactive ingredient of cannabis, a drug which is commonly smoked This paper focuses on the pharmacokinetics of THC. The average THC content in cannabis plant material has risen by a factor offour over the past 20 years, from 4% to 16%. This increase has important implications not only for the pharmacokinetics but also for the pharmacology of THC The mean bioavailability of THC in smoked cannabis is about 25%. Read More

    [Neurobiology of endocannabinoids and central effects of tetrahydrocannabinol contained in indian hemp].
    Bull Acad Natl Med 2014 Mar;198(3):527-38; discussion 538-9
    Tetrahydrocannabinol, the main psychotropic component of Cannabis indica, is an addictive drug with multiple effects including both peripheral and central damages. All these effects are due to interference with endocannabinoidergic transmission. This endocannabinoid system subtly regulates many physiologicalfunctions. Read More

    [Cannabis in France, new insights].
    Bull Acad Natl Med 2014 Mar;198(3):517-26
    France holds the record for cannabis use in Europe, especially among adolescents. This drug of abuse is thus mainly used during a very sensitive period of brain development, education, vehicle driving and development of life projects. In addition, synthetic derivatives of tetrahydrocannabinol (THC), which are more noxious than cannabis itself are now appearing on the market. Read More

    [Benefits and indications of rehabilitation for coronary heart diseases].
    Bull Acad Natl Med 2014 Mar;198(3):501-14; discussion 514-5
    Cardiac rehabilitation (CR) is an essential element in the treatment of coronary artery disease. It can be conducted on an inpatient or ambulatory basis in cardiac rehabilitation units and includes complementary exercise training and a therapeutic patient education (TPE) program. Rehabilitation can reduce the occurrence of serious cardiac events and provide better control of cardiovascular risk factors. Read More

    [Cardiac rehabilitation: physiologic basis, beneficial effects and contraindications].
    Bull Acad Natl Med 2014 Mar;198(3):491-9
    Cardiac rehabilitation can reduce morbidity and mortality cost-effectively among patients with many types of cardiovascular disease yet is widely underutilized. Rehabilitation is helpful not only for patients who have had myocardial infarction but also for those with stable angina or congestive heart failure and those who have undergone myocardial revascularization, transplantation, or valve surgery. The beneficial effects of rehabilitation include a reduction in mortality from cardiovascular disease, improved exercise tolerance, and fewer cardiac symptoms. Read More

    [Future of implantable electrical cardiac devices].
    Bull Acad Natl Med 2014 Mar;198(3):473-87; discussion 487-8
    Major improvements in implantable electrical cardiac devices have been made during the last two decades, notably with the advent of automatic internal defibrillation (ICD) to prevent sudden arrhythmic death, and cardiac resynchronisation (CRT) to treat the discoordinated failing heart. They now constitute a major therapeutic option and may eventually supersede drug therapy. The coming era will be marked by a technological revolution, with improvements in treatment delivery, safety and efficacy, and an expansion of clinical indications. Read More

    [Anomalous aortic origin of coronary arteries: a frequent and curable cause of sudden death].
    Bull Acad Natl Med 2014 Mar;198(3):465-70; discussion 470-1
    Anomalous aortic origin of coronary arteries is a congenital heart defect in which one coronary artery arises from the opposite sinus (the left coronary artery from the right coronary sinus, or the right coronary artery from the left sinus). The initial segment of the abnormal artery courses between the great arteries and is usually located within the aortic wall. These anomalies are far from rare, affecting 0. Read More

    [Innovative treatments for multidrug-resistant bacteria].
    Bull Acad Natl Med 2014 Mar;198(3):439-56; discussion 456-7
    The spread of multidrug-resistant bacteria has accelerated sharply in the last decade. According to the World Health Organization they are responsible for an estimated 25 000 deaths in Europe each year. In addition, few new antibiotics are under development, raising the spectrum of a return to the "pre-antibiotic era". Read More

    [Gram positive multi-drug resistance: what probability and fear?].
    Bull Acad Natl Med 2014 Mar;198(3):427-38; discussion 438
    Antibiotic resistance in Gram-positive bacteria already has a significant impact on morbidity and mortality. The situation is particularly alarming in the case of methicillin-resistant Staphylococcus aureus and glycopeptide-resistant Enterococcus faecium, which have shown an ability to spread to new ecological niches and to generate new clones with both increased drug resistance and increased virulence. The potential for genetic exchanges between these two species raises the specter of highly resistant and virulent S. Read More

    [Béla Bartók's disease: a hidden leukemia, a defeated leukemia].
    Bull Acad Natl Med 2015 Apr-May;199(4-5):717-28
    The hematological disorder Béla Bartók suffered during his exile in the United States and that led to his death has long remained mysterious, as well as the lung disease that accompanied it. The present historical evocation offers us the opportunity to explain the remarkable biological and therapeutic advances obtained in the field of chronic myelocytic leukemia during the last decades. Read More

    [NADPH oxidase Nox4, a putative therapeutic target in osteoarthritis].
    Bull Acad Natl Med 2015 Apr-May;199(4-5):673-86; discussion 686-7
    The NADPH oxidases, Nox, are transmembrane hemoproteins, whose exclusive function is to reduce molecular oxygen to produce superoxide anion O2°- and consequently highly reactive oxidant and toxic oxygen species, ROS. Among the 7 NADPH oxidases expressed in humans, Nox4 is the sole Nox isoform present in human primary chondrocytes. Nox4 was suggested as one of the main actors involved in cartilage degradation in osteoarthritis. Read More

    [The Emergence of Ebola virus in humans: a long process not yet fully understood].
    Bull Acad Natl Med 2015 Apr-May;199(4-5):651-69; discussion 669-71
    Since 1976 Ebola virus regularly has caused small deadly outbreaks in Central Africa, usually controlled in a few months. For the first time, an Ebola epidemic of exceptional magnitude dramatically engulfed several countries in West Africa since December 2013. Major failures of implementing measures to prevent human-to-human transmissions are the main cause of this large-scale Ebola outbreak. Read More

    [New approach for managing microbial risks in food].
    Bull Acad Natl Med 2015 Apr-May;199(4-5):639-48; discussion 648-50
    The aim of the food legislation is to ensure the protection of human health. Traditionally, the food legislation requires food business operators to apply good hygiene practices and specific procedures to control foodborne pathogens. These regulations allowed reaching a high level of health protection. Read More

    [Not Available].
    Bull Acad Natl Med 2015 Apr-May;199(4-5):629-38
    Evaluation and research of quality factors in surgery necessitates the consideration of 3 types of indicators: indicators of structures, indicators of processes and indicators of outcomes. We used these 3 types of indicators to assess the quality of thyroid surgery and to evaluate quality indicators. These studies allowed us to demonstrate the importance of a permanent monitoring of the outcomes of the thyroid surgery and the presence of human and organizational factors in the mechanisms of the surgical complications. Read More

    [Lyme borreliosis and co-infections. Place of Anaplasma phagocytophilum and Bartonella henselae].
    Bull Acad Natl Med 2015 Apr-May;199(4-5):617-26; discussion 626-8
    Lyme borreliosis (LB) is certainly the most common infection transmitted through the bite of Ixodes in Northern Hemisphere. These ticks are also able to transmit other microorganisms such as the bacteria Anaplasma phagocytophilum (Ap) and Bartonella henselae (Bh), with the latter discovered fairly recently, leading to diferent clinical presentations often close to those of LB. The aim of this study was to evaluate the frequency of co-infection by either of these bacteria in patients with LB, particularly when a treatment with beta-lactam antibiotic was only partially effective. Read More

    [Pendred syndrome and nonsyndromic related deafness: a same entity?].
    Bull Acad Natl Med 2015 Apr-May;199(4-5):601-15; discussion 615-6
    Pendred syndrome is an autosomal recessive familial disorder, defined as a sensorineural deafness coinciding with a goiter related to an iodine organification defect. It constitutes 4 to 10 % of all causes of familial congenital hearing loss. It is now well established that this condition was caused by mutations in the SLC26A4 gene which codes for pendrin, a protein involved in the transport of anions (I-, Cl, HCO3-), particularly in apical iodine efflux in thyroid cells and chloride (Cl-|HCO3-) at the cochlear level. Read More

    [Patients' associations and clinical research--academic and industrial].
    Bull Acad Natl Med 2015 Apr-May;199(4-5):589-96
    The notion of "health democracy" was introduced as a core principle into the French health law in 2002. Accordingly, stronger individual rights were recognized to patients and, at the same time, patients' representatives have progressively served at all levels of the governance of health system. In clinical research, it is mandatory since 2004 that institutional review board include patient representatives (I). Read More

    [Not Available].
    Bull Acad Natl Med 2015 Apr-May;199(4-5):581-7
    To date, work on health democracy has never dealt with relationships between patient associations and the pharmaceutical industry. The emergence of a genuine health citizenship depends, however, to a great extent on the quality of such a relationship. This communication, which is based on a survey of 1742 patient associations and 270 French-pharmaceutical companies, conducted by BVA upon request of the Ethics Commitee of the French association of pharmaceutical companies (CODEEM) highlights the significance of the ethical issues. Read More

    [Not Available].
    Bull Acad Natl Med 2015 Apr-May;199(4-5):571-80
    After the second World War, during which medicine was manipulated to serve an ideology, a deep movement arised to protect human beings. In 1964, Helsinki declaration was adapted to protect persons involved in medical research. In 1988, the Séruscalt-Huriet law introduced the obligation of informed consent. Read More

    [Chronic pain management: societal impact].
    Bull Acad Natl Med 2015 Apr-May;199(4-5):555-65
    Pain is a real issue of public health, quality and evolution of a system of health test: this is a major social problem. Pain management meets a humanistic, ethical purpose and dignity of man because of the physical and psychological implications. It induces a disability which excludes the patient of society gradually or suddenly. Read More

    [Chronic pain: emotional and cognitive consequences].
    Bull Acad Natl Med 2015 Apr-May;199(4-5):543-54
    Chronic pain which had become a major public health problem, is always accompanied with emotional and cognitive disorders. These comorbidities are circular and auto generated as in low back pain or in somatoform pain as fibromyalgia. Cerebral imagery of pain show the superposition of emotional and cognitive circuits especially in frontal regions from where come the descending control of pain. Read More

    [On the borders of the neurology and the rheumatology].
    Bull Acad Natl Med 2015 Apr-May;199(4-5):533-42
    The links between the rheumatology and the neurology, are ancient and established of one intricacy of pathologies and symptoms. It is not a question here of approaching the inflammatory myositis nor the neurological, essentially central signs, during the inflammatory diseases still called systematic as the lupus or the syndrome of Gougerot-Sjögren, neither compression occurring during rheumatoid arthritis and ankylosing spondylarthritis. It is not either a question of reviewing the compression of osseous origin, as for example the narrow cervical spine, the narrow lumbar spine or the basilaire impression during the bony disease of Paget. Read More

    [Not Available].
    Bull Acad Natl Med 2015 Apr-May;199(4-5):515-23
    In solid organ transplant, immunosuppressive therapy helped to increase graft and patient survival. However, these treatments are associated with toxic risks and infectious or tumor complications. The identification of immunoregulatory properties of regulatory cells and in particular Mesenchymal Stem Cells opens new therapeutic perspectives in the prevention of acute rejection and for the treatment of chronic rejection. Read More

    [Paracrine properties of Mesenchymal Stromal Cells].
    Bull Acad Natl Med 2015 Apr-May;199(4-5):501-14
    Mesenchymal stromal cells are multipotent cells found in a large number of adult tissues. Their ability to participate in the repair of these damaged tissues is the origin of the enthusiasm that they elicit in the field of cell therapy. It gradually became apparent that their ability to change a pathological environment is more related to their ability to modulate the behavior of other cell types than their capacity of diferentiation. Read More

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