215,497 results match your criteria Building Research And Information[Journal]


Impaired learning from punishment of errors in smokers: Differences in dorsolateral prefrontal cortex and sensorimotor cortex blood-oxygen-level dependent responses.

Neuroimage Clin 2019 Apr 8;23:101819. Epub 2019 Apr 8.

School of Psychological Sciences, University of Melbourne, 12th floor Redmond Barry Building, Parkville Campus, Melbourne, VIC 3010, Australia. Electronic address:

Cigarette smokers have shown hypersensitivity to reward and hyposensitivity to punishment, along with impairments in learning from errors. The underlying neural mechanism for this failure to adapt performance following an error, particularly when receiving negative feedback, are unclear. Smokers were hypothesized to have poorer error-learning following monetary punishment, associated with hypoactivation in the insula, dorsal anterior cingulate, and hippocampal cortical regions. Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101819DOI Listing

Biopolitics, space and hospital reconfiguration.

Soc Sci Med 2019 Apr 13;230:111-121. Epub 2019 Apr 13.

Public Service Management, King's Business School, King's College London, Bush House, 30 Aldwych, London, WC2B 4BG, United Kingdom. Electronic address:

Major service change in healthcare - whereby the distribution of services is reconfigured at a local or regional level - is often a contested, political and poorly understood set of processes. This paper contributes to the theoretical understanding of major service change by demonstrating the utility of interpreting health service reconfiguration as a biopolitical intervention. Such an approach orients the analytical focus towards an exploration of the spatial and the population - crucial factors in major service change. Read More

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http://dx.doi.org/10.1016/j.socscimed.2019.04.011DOI Listing

Opportunities of electrokinetics for the remediation of mining sites in Biga peninsula, Turkey.

Chemosphere 2019 Apr 15;227:606-613. Epub 2019 Apr 15.

Department of Geological Engineering, Canakkale Onsekiz Mart University, Canakkale, Turkey.

This study investigated the geological conditions of Biga Peninsula. There are metamorphic rocks, ophiolitic melange, plutonic rocks, subvolcanics, volcanic rocks and volcanoclastics along with marine and terrestrial sediments in the region. This variety of rocks and the associated minerals resulted in many interesting metallic ores and coal for commercial exploitation. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.059DOI Listing

Corrigendum to "The moderating effect of perceived social support on the relation between heaviness of smoking and quit attempts among adult homeless smokers" [Drug and Alcohol Depend. 190 (2018) 128-132].

Drug Alcohol Depend 2019 Apr 19;199:69. Epub 2019 Apr 19.

The University of Oklahoma Health Sciences Center, Oklahoma Tobacco Research Center, 655 Research Parkway, Suite 400, Oklahoma City, OK, 73104, USA.

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http://dx.doi.org/10.1016/j.drugalcdep.2019.04.003DOI Listing

Corrigendum to "Concurrent nicotine and tobacco product use among homeless smokers and associations with cigarette dependence and other factors related to quitting" [Drug Alcohol Depend. 185 (2018) 133-140].

Drug Alcohol Depend 2019 Apr 19;199:68. Epub 2019 Apr 19.

Oklahoma Tobacco Research Center, The University of Oklahoma Health Sciences Center, 655 Research Parkway, Suite 400, Oklahoma City, OK, 73104, United States.

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http://dx.doi.org/10.1016/j.drugalcdep.2019.04.002DOI Listing

Lung Cancer Risk in Never Smokers of European Descent is Associated with Genetic Variation in the 515.33 TERT-CLPTM1L Region.

J Thorac Oncol 2019 Apr 19. Epub 2019 Apr 19.

Geisel School of Medicine at Dartmouth, 1 Medical Center Dr, Lebanon, NH 03756, USA. Electronic address:

Introduction: Inherited susceptibility to lung cancer risk in never smokers is poorly understood. The major reason for this gap in knowledge is that this disease is relatively uncommon (except in Asians), making it difficult to assemble an adequate study sample. In this study we conducted a genome-wide association study (GWAS) on the largest, to date, set of European-descent never smokers with lung cancer. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15560864193028
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http://dx.doi.org/10.1016/j.jtho.2019.04.008DOI Listing
April 2019
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Using SHAPE-MaP to probe small molecule-RNA interactions.

Methods 2019 Apr 19. Epub 2019 Apr 19.

Department of Biological Sciences, Auburn University, 120 W. Samford Ave, Rouse Life Sciences Building, Auburn, AL 36849, USA. Electronic address:

RNA is a regulator and catalyst of many cellular processes. Efforts to therapeutically harness RNA began with the discovery of myriad coding and non-coding RNAs and their versatile modes of action. However, due to its dynamic structure and the polar and repetitive nature of its surface, RNA presents a challenging target for drug design. Read More

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http://dx.doi.org/10.1016/j.ymeth.2019.04.009DOI Listing

Genome-wide annotation and comparative analysis of cuticular protein genes in the noctuid pest Spodoptera litura.

Insect Biochem Mol Biol 2019 Apr 19. Epub 2019 Apr 19.

State Key Laboratory of Silkworm Genome Biology, Biological Science Research Center, Southwest University, Chongqing, 400716, China; Chongqing Key Laboratory of Sericultural Science, Chongqing Engineering and Technology Research Center for Novel Silk Materials, Southwest University, Chongqing, 400716, China. Electronic address:

Insect cuticle is considered an adaptable and versatile building material with roles in the construction and function of exoskeleton. Its physical properties are varied, as the biological requirements differ among diverse structures and change during the life cycle of the insect. Although the bulk of cuticle consists basically of cuticular proteins (CPs) associated with chitin, the degree of cuticular sclerotization is an important factor in determining its physical properties. Read More

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http://dx.doi.org/10.1016/j.ibmb.2019.04.012DOI Listing

Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders.

Free Radic Biol Med 2019 Apr 19. Epub 2019 Apr 19.

Institute of Life Science, Swansea University Medical School, Singleton Park, Swansea, SA2 8PP, UK. Electronic address:

Cholestane-3β,5α,6β-triol (3β,5α,6β-triol) is formed from cholestan-5,6-epoxide (5,6-EC) in a reaction catalysed by cholesterol epoxide hydrolase, following formation of 5,6-EC through free radical oxidation of cholesterol. 7-Oxocholesterol (7-OC) and 7β-hydroxycholesterol (7β-HC) can also be formed by free radical oxidation of cholesterol. Here we investigate how 3β,5α,6β-triol, 7-OC and 7β-HC are metabolised to bile acids. Read More

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.020DOI Listing

Computational model of the dual action of PTH - Application to a rat model of osteoporosis.

J Theor Biol 2019 Apr 19. Epub 2019 Apr 19.

St Vincent's Department of Surgery, The University of Melbourne, Clinical Science Building, 29 Regent Street, Fitzroy VIC 3065, Australia; School of Chemistry, Physics and Mechanical Engineering, Queensland University of Technology, 2 George Street, Brisbane QLD 4000, Australia.

This paper presents a pharmacokinetic/pharmacodynamic (PK/PD) model of the action of PTH(1-34) on bone modelling and remodelling, developed for quantitatively investigating the dose- and administration pattern-dependency of the bone tissue response to this drug. Firstly, a PK model of PTH(1-34) was developed, accounting for administration via subcutaneous injections. Subsequently, the PK model was coupled to a (mechanistic) bone cell population model of bone modelling and remodelling, taking into account the effects of PTH(1-34) on the differentiation of lining cells into active osteoblasts, on the apoptosis of active osteoblasts, and on proliferation of osteoblast precursors, as well as on the key regulatory pathways of bone cell activities. Read More

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http://dx.doi.org/10.1016/j.jtbi.2019.04.020DOI Listing

Nanoparticle-Assembled Thin Film with amphipathic nanopores for Organic Solvent Nanofiltration.

ACS Appl Mater Interfaces 2019 Apr 22. Epub 2019 Apr 22.

Polymeric thin film composite (TFC) membranes have been proved promising for a wide range of separation applications. However, their development is significantly hindered by low permeance (below 8.0 L m-2 h-1 bar-1). Read More

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http://dx.doi.org/10.1021/acsami.9b03753DOI Listing

Synthesis of Structurally Diverse 3-, 4-, 5- and 6-Membered Heterocycles from Diisopropyl Iminomalonates and Soft C-Nucleophiles.

J Org Chem 2019 Apr 22. Epub 2019 Apr 22.

Herein, we present a general synthetic strategy for the preparation of 3-, 4-, 5- and 6-membered heterocyclic unnatural amino acid derivatives by exploiting facile Mannich-type reactions between readily available N-alkyl- and N-aryl-substituted diisopropyl iminomalonates and a wide range of soft anionic C-nucleophiles without using any catalyst or additive. Fully substituted aziridines were obtained in a single step when enolates of alpha-bromo esters were employed as nucleophiles. Enantiomerically enriched azetidines, γ-lactones and tetrahydroquinolines were obtained via a two-step catalytic asymmetric reduction and cyclization sequence from ketone enolate-derived adducts. Read More

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http://dx.doi.org/10.1021/acs.joc.9b00681DOI Listing

Rapid profiling of triglycerides in human breast milk using LESA-FTMS reveals new VLCFAs and differences within individuals.

Rapid Commun Mass Spectrom 2019 Apr 22. Epub 2019 Apr 22.

Nutrition and Bone Health group MRC HNR, Cambridge, CB1 9NL, United Kingdom.

Rationale: In this paper, we describe a novel method for preparing milk samples and profiling the triglyceride fraction from them. This method was used to explore how the triglyceride (TG) profile of milk modulates as lactation progresses and how the TG profile differs between breasts.

Methods: Fresh milk was spotted onto Whatman filter paper and air-dried. Read More

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http://dx.doi.org/10.1002/rcm.8465DOI Listing

Building an Ambulatory Safety Program at an Academic Health System.

J Patient Saf 2019 Apr 18. Epub 2019 Apr 18.

Division of General Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland.

Background: Patient safety has traditionally focused on the inpatient setting; however, there is an increased awareness of ambulatory safety risk. However, successful strategies and programs to mitigate risk in the ambulatory setting are lacking.

Program: In 2012, we started building a multidisciplinary ambulatory safety program at an academic health system. Read More

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http://dx.doi.org/10.1097/PTS.0000000000000594DOI Listing

QUANTIFYING THE SEVERITY OF GIRAFFE SKIN DISEASE VIA PHOTOGRAMMETRY ANALYSIS OF CAMERA TRAP DATA.

J Wildl Dis 2019 Apr 22. Epub 2019 Apr 22.

1   Research on the Ecology of Carnivores and Their Prey Laboratory, Department of Fisheries and Wildlife, Michigan State University, 480 Wilson Road, 13 Natural Resources Building, East Lansing, Michigan 48824, USA.

Developing techniques to quantify the spread and severity of diseases afflicting wildlife populations is important for disease ecology, animal ecology, and conservation. Giraffes () are in the midst of a dramatic decline, but it is not known whether disease is playing an important role in the broad-scale population reductions. A skin disorder referred to as giraffe skin disease (GSD) was recorded in 1995 in one giraffe population in Uganda. Read More

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Advancing Cancer Research in Africa Through Early-Career Awards: The BIG Cat Initiative.

J Glob Oncol 2019 Apr(5):1-8

5 National Institute of Mental Health, Bethesda, MD.

Purpose: The burden of cancer in Africa is growing rapidly, and increased cancer research on the continent is a critical component of an effective response. In 2010, the US National Cancer Institute, in partnership with the African Organization for Research and Training in Cancer, launched the Beginning Investigator Grant for Catalytic Research (BIG Cat) initiative to support cancer research projects conducted by early-career African investigators.

Methods: To date, BIG Cat has provided 18 awards of up to $50,000 to support 2-year cancer research projects. Read More

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http://dx.doi.org/10.1200/JGO.18.00223DOI Listing

Development of a Biobank from a Legacy Collection in Universitas Gadjah Mada, Indonesia: Proposed Approach for Centralized Biobank Development in Low-Resource Institutions.

Biopreserv Biobank 2019 Apr 19. Epub 2019 Apr 19.

2 Biobank Development Team, Molecular Biology Laboratory, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada (FK-KMK UGM), Yogyakarta, Indonesia.

The establishment of a biobank requires specific expertise along with relatively expensive infrastructure and appropriate technology. This causes certain challenges in biobank implementation for research in low-middle-income countries. Biobank development with established specimens and data collection (legacy collection) was an approach used in the Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada. Read More

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http://dx.doi.org/10.1089/bio.2018.0125DOI Listing

Law and Disorder: Special Stacking Units-Building the Intergrowth CeCoGe.

Inorg Chem 2019 Apr 22. Epub 2019 Apr 22.

Center for Nanophysics and Advanced Materials, Department of Physics , University of Maryland , College Park , Maryland 20742 , United States.

A new structure type of composition CeCoGe was grown out of a molten Sn flux. CeCoGe crystallizes in the orthorhombic space group Cmcm, with highly anisotropic lattice parameters of a = 4.3293(5) Å, b = 55. Read More

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http://dx.doi.org/10.1021/acs.inorgchem.9b00350DOI Listing

Design and Solid-Phase Parallel Synthesis of 2,4,5-Trisubstituted Thiazole Derivatives via Cyclization Reaction with a Carbamimidothioate Linker.

ACS Comb Sci 2019 Apr 22. Epub 2019 Apr 22.

Preparation of 2,4,5-trisubstituted thiazole derivatives via a new solid-phase synthetic route has been conducted in this study. The synthetic route begins with synthesis of a core skeleton 2,4-diamino(thiazole-5-yl)substituted-phenylmethanone resin, obtained through a cyclization reaction with a carbamimidothioate linker. The core skeleton was substituted with diverse building blocks such as amines, alkyl halides, and acid chlorides. Read More

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http://pubs.acs.org/doi/10.1021/acscombsci.9b00039
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http://dx.doi.org/10.1021/acscombsci.9b00039DOI Listing
April 2019
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Every Nurse Is a Leader: Building on 50 Years of Nephrology Nursing Leadership.

Authors:
Tamara M Kear

Nephrol Nurs J 2019 Mar-Apr;46(2):101-154

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Projecting impacts of global climate and land-use scenarios on plant biodiversity using compositional-turnover modelling.

Glob Chang Biol 2019 Apr 22. Epub 2019 Apr 22.

CSIRO Land and Water, Building 101, Black Mountain Laboratories, Clunies Ross St., Canberra, ACT, 2601, Australia.

Nations have committed to ambitious conservation targets in response to accelerating rates of global biodiversity loss. Anticipating future impacts is essential to inform policy decisions for achieving these targets, but predictions need to be of sufficiently high spatial resolution to forecast the local effects of global change. As part of the intercomparison of biodiversity and ecosystem services models of the IPBES, we present a fine-resolution assessment of trends in the persistence of global plant biodiversity. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/gcb.14663
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http://dx.doi.org/10.1111/gcb.14663DOI Listing
April 2019
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WHEN Fluorescence is not a particle: The tissue translocation of microplastics in Daphnia magna seems an artIfact.

Environ Toxicol Chem 2019 Apr 22. Epub 2019 Apr 22.

Department of Biology, Norwegian University of Science and Technology, Høgskoleringen 1, Trondheim, Norway.

Previous research reported the translocation of nano- and microplastics from the gastrointestinal tract to tissues in Daphnia magna, most prominently of fluorescent polystyrene (PS) beads to lipid droplets. For particles > 300 nm, such transfer is biologically implausible as the peritrophic membrane retains these in the daphnid gut. Thus, we aim at replicating the key study by Rosenkranz et al. Read More

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http://dx.doi.org/10.1002/etc.4436DOI Listing

Personality, Cognitive Ability, and Academic Performance: Differential Associations Across School Subjects and School Tracks.

J Pers 2019 Apr 22. Epub 2019 Apr 22.

GESIS - Leibniz Institute for the Social Sciences, Mannheim, Germany.

Aim: Personality traits and cognitive ability are well-established predictors of academic performance. Yet, how consistent and generalizable are the associations between personality, cognitive ability, and performance? Building on theoretical arguments that trait-performance relations should vary depending on the demands and opportunities for trait expression in the learning environment, we investigated whether the associations of personality (Big Five) and cognitive ability (fluid intelligence) with academic performance (grades and tests scores) vary across school subjects (German and math) and across ability-grouped school tracks (academic, intermediate, vocational).

Method: Multiple-group structural equation models in a large representative sample of ninth-grade students from the German National Educational Panel Study (NEPS; N = 12,915). Read More

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http://dx.doi.org/10.1111/jopy.12482DOI Listing

A Guide to Build a Highly Inclined Swept Tile Microscope for Extended Field-of-view Single-molecule Imaging.

J Vis Exp 2019 Apr 8(146). Epub 2019 Apr 8.

CREOL, The College of Optics and Photonics, University of Central Florida;

Single-molecule imaging has greatly advanced our understanding of molecular mechanisms in biological studies. However, it has been challenging to obtain large field-of-view, high-contrast images in thick cells and tissues. Here, we introduce highly inclined swept tile (HIST) microscopy that overcomes this problem. Read More

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http://dx.doi.org/10.3791/59360DOI Listing

Hedonic drinking engages a supraspinal inhibition of thermal nociception in adult rats.

Pain 2019 05;160(5):1059-1069

Department of Neurobiology and Physiology, School of Dentistry, Dental Research Institute, Seoul National University, Seoul, Korea.

The taste of sucrose is commonly used to provide pain relief in newborn humans and is innately analgesic to neonatal rodents. In adulthood, sucrose remains a strong motivator to feed, even in potentially hazardous circumstances (ie, threat of tissue damage). However, the neurobiological mechanisms of this endogenous reward-pain interaction are unclear. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001482DOI Listing
May 2019
1 Read

Isomeric quinoxalinedicarbonitrile as color managing acceptors of thermally activated delayed fluorescent emitters.

ACS Appl Mater Interfaces 2019 Apr 22. Epub 2019 Apr 22.

Highly efficient yellow and red thermally activated delayed fluorescent (TADF) organic light emitting diodes were developed using two quinoxalinedicarbonitrile units, quinoxaline-6,7-dicarbonitrile (6,7-DCQx) and quinoxaline-5,8-dicarbonitrile (5,8-DCQx), as electron acceptors, and t-butyl carbazole or 9,9-dimethylacridan as electron donors. The strong electron withdrawing capability of the 5,8-DCQx and 6,7-DCQx acceptors enabled from yellow to red emission in the TADF emitters. Comparing the 5,8-DCQx and 6,7-DCQx, red-shifted emission by about 40 nm was observed in the 5,8-DCQx acceptor based emitters, but the external quantum efficiency of the TADF devices was over 20 % irrespective of the acceptor, proving the usefulness of the two acceptor moieties as the building blocks of the TADF emitters. Read More

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http://dx.doi.org/10.1021/acsami.9b02824DOI Listing

Between Perfectly Critical and Fully Irregular: A Reverberating Model Captures and Predicts Cortical Spike Propagation.

Cereb Cortex 2019 Apr 22. Epub 2019 Apr 22.

Max-Planck-Institute for Dynamics and Self-Organization, Am Faß berg 17, 37077 Göttingen, Germany.

Knowledge about the collective dynamics of cortical spiking is very informative about the underlying coding principles. However, even most basic properties are not known with certainty, because their assessment is hampered by spatial subsampling, i.e. Read More

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http://dx.doi.org/10.1093/cercor/bhz049DOI Listing

Strengths in patients with schizophrenia and healthy people - similarities and differences.

Psychiatr Pol 2019 Feb 28;53(1):93-104. Epub 2019 Feb 28.

Akademia Pedagogiki Specjalnej im. Marii Grzegorzewskiej, Instytut Psychologii.

Objectives: The aim of the study was to assess the character strengths of people with schizophrenia and their importance in building life satisfaction, and also to identify differences and similarities in the character strengths between people with schizophrenia and healthy people.

Methods: 40 people with diagnosed schizophrenia and 40 healthy people participated in the study. Each participant was examined with the following tools: Socio-Demographic Data Questionnaire, Satisfaction with Life Scale (SWLS), International Personality Item Pool - Values in Action (IPIP-VIA). Read More

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http://dx.doi.org/10.12740/PP/81109DOI Listing
February 2019

Assessment of air flow distribution and hazardous release dispersion around a single obstacle using Reynolds-averaged Navier-Stokes equations.

Heliyon 2019 Apr 9;5(4):e01482. Epub 2019 Apr 9.

Centre for Computational Engineering Sciences, Cranfield University, College Road, Cranfield, MK43 0AL, UK.

The flow around a cubical building, with a pollution source at the central point of the top of the cube, is studied. The Reynolds-averaged Navier-Stokes and species concentration equations are solved for Reynolds number, Re = 40,000, is based on the height of the cube. The predictions obtained with the standard, the Kato-Launder, and the low-Reynolds number k-epsilon models are examined with various wall functions for the near wall treatment of the flow. Read More

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http://dx.doi.org/10.1016/j.heliyon.2019.e01482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458475PMC

European Stroke Organisation certification of stroke units and stroke centres.

Eur Stroke J 2018 Sep 24;3(3):220-226. Epub 2018 May 24.

Department of Neurology and Stroke Center, University Hospital Basel, Basel, Switzerland.

To improve quality and to overcome the wide discrepancies in stroke care both within- and between European countries, the European Stroke Organisation Executive Committee initiated in 2007 activities to establish certification processes for stroke units and stroke centres. The rapidly expanding evidence base in stroke care provided the mandate for the European Stroke Organisation Stroke Unit-Committee to develop certification procedures for stroke units and stroke centres with the goals of setting standards for stroke treatment in Europe, improving quality and minimising variation. The purpose of this article is to present the certification criteria and the auditing process for stroke units and stroke centres that aim to standardise and harmonise care for stroke patients, and hence become members of the European Stroke Organisation Stroke Unit and Stroke Centre network. Read More

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http://dx.doi.org/10.1177/2396987318778971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453203PMC
September 2018

Intervention strategies for improvement of disasters risk perception: Family-centered approach.

J Educ Health Promot 2019 14;8:63. Epub 2019 Mar 14.

Department of Health in Disaster and Emergency, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Introduction: Today, the role of people in crisis management plans is of particular importance due to the prepared community approach. It is difficult or impossible to attract public involvement due to the low level of public perception of risk. Therefore, it is necessary to discover the status of risk perception and its affecting factors. Read More

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http://dx.doi.org/10.4103/jehp.jehp_200_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442268PMC

Best practices to impart clinical skills during preclinical years of medical curriculum.

J Educ Health Promot 2019 14;8:57. Epub 2019 Mar 14.

Department of Clinical Medical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago.

Globally, health is regarded as a booming industry with greater stress being laid on high quality, accountability, and transparency. Traditional medical curricula rely primarily on clerkships during the clinical period of study to train clinical skills, while the preclinical period is mainly used to teach the basic sciences. In recent years, the early introduction of clinical skills training has received increased attention. Read More

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http://dx.doi.org/10.4103/jehp.jehp_354_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442250PMC

Risk-based monitoring: Review of the current perceptions and toward effective implementation.

Perspect Clin Res 2019 Apr-Jun;10(2):57-61

CEO, Medicines n We, Clinical Research and Healthcare Consultant, Mumbai, Maharashtra, India.

The United States Food and Drug Administration issued a guidance to industry in August 2013 on risk-based approach to monitoring. This prompted industry (sponsors and contract research organizations) to brainstorm, conceptualize, and implement risk-based monitoring (RBM) in their clinical studies and programs. The acceptance and implementation across the organizations have been variable in terms of pace and methodology. Read More

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http://dx.doi.org/10.4103/picr.PICR_18_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463506PMC

An Organic Zeolite With 10 Å Diameter Pores Assembles From a Soluble and Flexible Building Block by Non-Covalent Interactions.

ChemistryOpen 2019 Apr 8;8(4):457-463. Epub 2019 Apr 8.

Department of Chemistry University of Aberdeen, Meston Walk Aberdeen AB24 3UE.

Two similar molecular building blocks, which both contain a hydrogen-bonded nitro group, have been prepared and crystallised. One structure has more flexibility with a butyl side chain which allows an open framework organic zeolite to form with large 10 Å diameter pores, whereas the other structure has less flexibility with an aryl side chain and is close packed. The pore size is comparable with those of the aluminophosphate VPI-5 (12 Å). Read More

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http://dx.doi.org/10.1002/open.201900006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454218PMC

Southern Ocean Biogeochemical Float Deployment Strategy, With Example From the Greenwich Meridian Line (GO-SHIP A12).

J Geophys Res Oceans 2019 Jan 21;124(1):403-431. Epub 2019 Jan 21.

Program in Atmospheric and Oceanic Sciences Princeton University Princeton NJ USA.

Biogeochemical Argo floats, profiling to 2,000-m depth, are being deployed throughout the Southern Ocean by the Southern Ocean Carbon and Climate Observations and Modeling program (SOCCOM). The goal is 200 floats by 2020, to provide the first full set of annual cycles of carbon, oxygen, nitrate, and optical properties across multiple oceanographic regimes. Building from no prior coverage to a sparse array, deployments are based on prior knowledge of water mass properties, mean frontal locations, mean circulation and eddy variability, winds, air-sea heat/freshwater/carbon exchange, prior Argo trajectories, and float simulations in the Southern Ocean State Estimate and Hybrid Coordinate Ocean Model (HYCOM). Read More

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http://dx.doi.org/10.1029/2018JC014059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472510PMC
January 2019

Anatomy of the Ediacaran rangeomorph .

Pap Palaeontol 2019 Feb 11;5(1):157-176. Epub 2018 Sep 11.

Department of Earth Sciences University of Cambridge Downing Street Cambridge CB2 3EQ UK.

The Ediacaran macrofossil Ford is perhaps the most iconic member of the Rangeomorpha: a group of seemingly sessile, frondose organisms that dominates late Ediacaran benthic, deep-marine fossil assemblages. Despite exhibiting broad palaeogeographical and stratigraphical ranges, there have been few morphological studies that consider the variation observed among populations of specimens derived from multiple global localities. We present an analysis of that evaluates specimens from the UK, Canada and Russia, representing the largest morphological study of this taxon to date. Read More

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http://dx.doi.org/10.1002/spp2.1234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472560PMC
February 2019

Hypermentalizing as a marker of borderline personality disorder in Italian adolescents: a cross-cultural replication of Sharp and colleagues' (2011) findings.

Borderline Personal Disord Emot Dysregul 2019 10;6. Epub 2019 Apr 10.

1Faculty of Psychology, Vita-Salute San Raffaele University, via Stamira d'Ancona 20, 20127 Milan, Italy.

Background: Extant literature indicates that Borderline Personality Disorder (BPD) may be reliably assessed in adolescence. Sharp and colleagues' (2011) suggested that mentalization could be an important early target for intervention in BPD adolescents and showed that hypermentalizing may represent an important marker to distinguish emerging BPD from adolescent turmoil. We aimed at testing if both dimensionally-assessed and categorically-diagnosed BPD was selectively associated with hypermentalizing errors on the Movie for the Assessment of Social Cognition (MASC) task in Italian adolescent inpatients and community adolescents. Read More

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http://dx.doi.org/10.1186/s40479-019-0104-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457008PMC
April 2019
1 Read

Life in as a unique environment in Turkey.

Ment Illn 2019 Mar 28;11(1):7884. Epub 2019 Mar 28.

Department of Child and Adolescent Psychiatry, Marmara University Medical School, Istanbul, Turkey.

Family building (FB) is a building where residents of different flats are close relatives. Being quite common in metropolitan areas, these unique psychosocial environments remain underexamined. We aimed to research into the interactions within the family and psychosocial features of FBs. Read More

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http://dx.doi.org/10.4081/mi.2019.7884DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452221PMC

Informed Consent in Biomedical Research.

Comput Struct Biotechnol J 2019 25;17:463-474. Epub 2019 Mar 25.

Independent Scientist, Ottawa, Canada.

Informed consent is the result of tumultuous events in both the clinical and research arenas over the last 100 years. Throughout this time, the notion of informed consent has shifted tremendously, both due to advances in medicine, as well as the type of data being gathered. As such, informed consent has misaligned with the goals of medical research. Read More

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http://dx.doi.org/10.1016/j.csbj.2019.03.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458444PMC

Electrochemical and Kinetic Insights into Molecular Water Oxidation Catalysts Derived from Cp*Ir(pyridine-alkoxide) Complexes.

ChemCatChem 2018 Oct 30;10(19):4280-4291. Epub 2018 Sep 30.

Centre for Sustainable Chemical Technologies University of Bath Claverton DownBath BA2 7AY United Kingdom.

We report the solution-phase electrochemistry of seven half-sandwich iridium(III) complexes with varying pyridine-alkoxide ligands to quantify electronic ligand effects that translate to their activity in catalytic water oxidation. Our results unify some previously reported electrochemical data of Cp*Ir complexes by showing how the solution speciation determines the electrochemical response: cationic complexes show over 1 V higher redox potentials that their neutral forms in a distinct demonstration of charge accumulation effects relevant to water oxidation. Building on previous work that analysed the activation behaviour of our pyalk-ligated Cp*Ir complexes -, we assess their catalytic oxygen evolution activity with sodium periodate (NaIO) and ceric ammonium nitrate (CAN) in water and aqueous BuOH solution. Read More

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http://dx.doi.org/10.1002/cctc.201800916DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470865PMC
October 2018

Development of QSAR machine learning-based models to forecast the effect of substances on malignant melanoma cells.

Oncol Lett 2019 May 25;17(5):4188-4196. Epub 2019 Feb 25.

Dermatology Research Laboratory, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

SK-MEL-5 is a human melanoma cell line that has been used in various studies to explore new therapies against melanoma in different experiments. Based on this study we report on the development of quantitative structure-activity relationship (QSAR) models able to predict the cytotoxic effect of diverse chemical compounds on this cancer cell line. The dataset of cytotoxic and inactive compounds were downloaded from the PubChem database. Read More

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http://dx.doi.org/10.3892/ol.2019.10068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466999PMC

Available from Available from A cluster of tuberculosis cases linked to smoking: An under-recognized challenge for tuberculosis elimination.

Authors:
E Rea T Leung

Can Commun Dis Rep 2018 Mar 1;44(3-4):86-90. Epub 2018 Mar 1.

Toronto Public Health, Toronto, ON.

Background: Smoking is known to increase the risk of tuberculosis (TB) infection, active TB disease, relapse following treatment and death from TB, but its significance is often underappreciated as a potentially reversible risk factor in public health and clinical TB practice in Canada.

Objective: To review the current evidence on smoking and the risk of TB, describe a cluster investigation of local TB transmission related to smoking in Toronto, Ontario, and discuss the practical implications of smoking for TB elimination in Canada.

Investigation And Public Health Response: Three TB cases were identified at the same workplace over a two year period. Read More

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Self-Assembly of Polyoxometalate-Peptide Hybrids in Solution: Elucidating the Contributions of Multiple Possible Driving Forces.

Eur J Inorg Chem 2019 Jan 14;2019(3-4):380-386. Epub 2018 May 14.

Department of Polymer Science University of Akron 44325 Akron OH USA.

Incorporating the building blocks of nature (e.g., peptides and DNA) into inorganic polyoxometalate (POM) clusters is a promising approach to improve the compatibilities of POMs in biological fields. Read More

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http://dx.doi.org/10.1002/ejic.201800158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472639PMC
January 2019

Reagent Controlled Stereoselective Assembly of α-(1,3)-Glucans.

European J Org Chem 2019 Mar 4;2019(10):1994-2003. Epub 2018 Oct 4.

Leiden Institute of Chemistry Leiden University Einsteinweg 55 2333 CC Leiden The Netherlands.

Pre-activation based glycosylations have become a very powerful tool in the assembly of oligosaccharides and the use of nucleophilic additives allows for the in situ generation of reactive intermediates with tailored reactivity. We here use a glycosylation strategy that is based on the use of per-benzylated imidate building blocks for the fully stereoselective construction of a spacer equipped α-1,3-octaglucan. We have used the trimethylsilyl iodide (TMSI)-triphenylphosphine oxide (PhP=O) for the stereoselective installation of an azidopropanol spacer and triflic acid (TfOH)-dimethyl formamide (DMF) enabled glycosylations for the coupling reactions with the secondary glucosyl C-3-alcohols. Read More

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http://dx.doi.org/10.1002/ejoc.201800894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470887PMC

A modelling approach for the nonlinear dynamics of assembled structures undergoing fretting wear.

Proc Math Phys Eng Sci 2019 Mar 20;475(2223):20180731. Epub 2019 Mar 20.

Imperial College London, London, SW7 2AZ, UK.

Assembled structures tend to exhibit nonlinear dynamic behaviour at high excitation levels due to the presence of contact interfaces. The possibility of building predictive models relies on the ability of the modelling strategy to capture the complex nonlinear phenomena occurring at the interface. One of these phenomena, normally neglected, is the fretting wear occurring at the frictional interface. Read More

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http://www.royalsocietypublishing.org/doi/10.1098/rspa.2018.
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http://dx.doi.org/10.1098/rspa.2018.0731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451990PMC
March 2019
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Preparing the femur before the acetabulum does not reduce total blood loss in primary total hip replacement.

J Orthop 2019 Jul-Aug;16(4):353-355. Epub 2019 Apr 7.

Avon Orthopaedic Centre, Southmead Hospital, Bristol, UK.

Introduction: Total hip replacement is a common and effective surgical intervention for patients with debilitating joint pain but it does represent a significant surgical intervention. For such interventions, blood loss is a potential cause of morbidity and mortality. Optimisation of surgical interventions focuses on reducing such risks. Read More

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http://dx.doi.org/10.1016/j.jor.2019.03.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458339PMC

Trends in obesity prevalence among total hip arthroplasty patients and the effect on surgical outcomes, 2008-2016.

J Orthop 2019 Jul-Aug;16(4):347-352. Epub 2019 Apr 7.

Chief of Orthopaedic Surgery at Pennsylvania Hospital, Assistant Professor of Orthopaedic Surgery, Department of Orthopaedic Surgery University of Pennsylvania, 800 Spruce Street, 8th Floor Preston Building, Philadelphia, PA, 19107, USA.

Introduction: The prevalence of obesity continues to rise in parallel with demand for total hip arthroplasty (THA). This study aims to report obesity trends in primary THA and its effects on procedure outcomes in the United States, stratifying based on Body Mass Index (BMI).

Methods: Primary THA procedures were identified in the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database (2008-2016). Read More

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http://dx.doi.org/10.1016/j.jor.2019.03.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458338PMC

Energy and environmental assessment of a traction lithium-ion battery pack for plug-in hybrid electric vehicles.

J Clean Prod 2019 Apr;215:634-649

European Commission, Joint Research Centre, Directorate for Energy, Transport and Climate, Energy Storage Unit, Westerduinweg 3, NL-1755 LE, Petten, the Netherlands.

Traction batteries are a key factor in the environmental sustainability of electric mobility and, therefore, it is necessary to evaluate their environmental performance to allow a comprehensive sustainability assessment of electric mobility. This article presents an environmental assessment of a lithium-ion traction battery for plug-in hybrid electric vehicles, characterized by a composite cathode material of lithium manganese oxide (LiMnO) and lithium nickel manganese cobalt oxide Li(NiCoMn)O. Composite cathode material is an emerging technology that promises to combine the merits of several active materials into a hybrid electrode to optimize performance and reduce costs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09596526193006
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http://dx.doi.org/10.1016/j.jclepro.2019.01.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472661PMC

Soil quality index: Exploring options for a comprehensive assessment of land use impacts in LCA.

J Clean Prod 2019 Apr;215:63-74

European Commission, Joint Research Centre, Via Enrico Fermi 2749, I-21027, Ispra VA, Italy.

Impacts associated with land use are increasingly recognized as important aspects to consider when conducting Life Cycle Assessment (LCA). Across the existing models accounting for land use activities in life cycle impact assessment, a balance is yet to be found between complexity and comprehensiveness on one hand, and applicability on the other hand. This work builds on the LANd use indicator value CAlculation (LANCA) model, assessing the impacts of land use activities on five soil properties, and aims at developing an aggregated index to improve its applicability. Read More

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http://dx.doi.org/10.1016/j.jclepro.2018.12.238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472660PMC