50,356 results match your criteria Buffalo Bulletin[Journal]


Effect of Fremanezumab Monthly and Quarterly Doses on Efficacy Responses.

Headache 2020 May 23. Epub 2020 May 23.

Teva Pharmaceutical Industries Ltd., Netanya, Israel.

Objective: Exposure-response (E-R) models were developed to provide a description of the time-course of treatment effect for monthly and quarterly dosing regimens of fremanezumab.

Background: Fremanezumab is a monoclonal antibody for preventive treatment of episodic migraine (EM) and chronic migraine (CM). In phase 2b and 3 clinical studies of fremanezumab, significant reductions in migraine and headache days and other clinical endpoints were observed for patients with EM and patients with CM. Read More

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http://dx.doi.org/10.1111/head.13845DOI Listing

Analysis of association between various fertility indicators and production traits in Mehsana buffaloes.

Trop Anim Health Prod 2020 May 23. Epub 2020 May 23.

Dudhsagar Research & Development Association, Dudhsagar Dairy, Mehsana, Gujarat, India.

Female fertility in domestic animals in India has exhaustively suffered owing to indiscriminate breeding with single objective of increasing milk production. First lactation data on 7782 Mehsana buffaloes sired by 184 bulls maintained under field progeny testing programme at Dudhsagar Research and Development Association, Dudhsagar Dairy, Mehsana, over a period of 24 years were used for study of fertility traits viz. days open, first to successful service period (FTSS) and daughter pregnancy rate (DPR) and production traits viz. Read More

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http://dx.doi.org/10.1007/s11250-020-02288-5DOI Listing

Semen production and semen quality of indigenous buffalo breeds under hot semiarid climatic conditions in India.

Trop Anim Health Prod 2020 May 22. Epub 2020 May 22.

Université Paris-Saclay, INRAE, AgroParisTech, GABI, 78350, Jouy-en-Josas, France.

Semen data comprising of 97,023 ejaculates of 197 bulls from 6 buffalo breeds were analyzed. The traits considered were as follows: ejaculate volume, sperm concentration, mass activity, initial and post-thaw motility, total sperm, and total motile sperm before and after thawing as well as a composite trait equal to the theoretical number of doses which can be produced from each given ejaculate. The objective was to measure the semen production potential of indigenous buffalo bulls and identify factors affecting these traits. Read More

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http://dx.doi.org/10.1007/s11250-020-02284-9DOI Listing

Human health risk assessment of heavy metals in raw milk of buffalo feeding at wastewater-irrigated agricultural farms in Pakistan.

Environ Sci Pollut Res Int 2020 May 22. Epub 2020 May 22.

Department of Environmental Sciences and Engineering, Government College University, Allama Iqbal Road, Faisalabad, Punjab, 38000, Pakistan.

Wastewater irrigation to grow fodder for animals and cattle farming is common practice in Pakistan. Hence, this study was conducted in Multan, Pakistan, to assess heavy metal pollution, human health risk and the total target health quotient (TTHQ) of heavy metals in raw milk of buffalo feeding at different agricultural farms and to identify sources of toxicity in milk. Samples of raw milk (n = 60) were analyzed for Cd, Cr, Cu, Mn, Ni, and Pb by ICP-OES, Perkin Elmer, USA. Read More

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http://dx.doi.org/10.1007/s11356-020-09256-4DOI Listing

Co-localization of circDYM with miR-9 in microglia.

Mol Psychiatry 2020 Jun;25(6):1155

Department of Pharmacology, School of Medicine, Southeast University, Nanjing, 210009, Jiangsu, China.

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http://dx.doi.org/10.1038/s41380-020-0780-yDOI Listing

Location of the accessory infraorbital foramen with reference to external landmarks and its clinical implications.

Sci Rep 2020 May 22;10(1):8566. Epub 2020 May 22.

Department of Ophthalmology, Blanton Eye Institute, Houston Methodist Hospital, Houston, Texas, USA.

The aim of this study was to define the location of the accessory infraorbital foramen (AIOF) with reference to accessible external landmarks in order to facilitate orbital and oculoplastic surgical procedures in the maxillofacial region. Forty-four hemifaces from 25 cadavers were dissected. The lateral canthus, subnasal point, and lacrimal caruncle were used as anatomic reference points. Read More

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http://dx.doi.org/10.1038/s41598-020-65330-4DOI Listing

Knowledge and Practice of Harm Reduction Strategies Among People Who Report Frequent Cannabis Use.

Health Promot Pract 2020 May 22:1524839920923999. Epub 2020 May 22.

University at Buffalo, Buffalo, NY, USA.

We examined knowledge and practice of harm reduction strategies among people who use cannabis attending an annual public cannabis advocacy event. We also assessed the sources from which they glean information about cannabis. Participants ( = 472) completed a brief survey assessing cannabis use, sources for information on cannabis, and harm reduction strategies. Read More

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http://dx.doi.org/10.1177/1524839920923999DOI Listing

Chiari type I malformation: role of the Chiari Severity Index and Chicago Chiari Outcome Scale.

J Neurosurg Pediatr 2020 May 22:1-7. Epub 2020 May 22.

1Surgical Outcome Center for Kids, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee.

Objective: The authors aimed to determine whether the Chiari Severity Index (CSI), and other clinical variables, can be used as a predictor of postoperative outcomes for Chiari type I malformation (CM-I) using the modified Chicago Chiari Outcome Scale (mCCOS) as the postoperative measure.

Methods: The cohort included patients 18 years of age and younger who were treated for CM-I between 2010 and 2015 who had at least 12 months of clinical and radiographic follow-up. CSI grades were assigned using preoperative clinical and neuroimaging data. Read More

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http://dx.doi.org/10.3171/2020.2.PEDS19770DOI Listing

Airway mir-155 responses are associated with TH1 cytokine polarization in young children with viral respiratory infections.

PLoS One 2020 22;15(5):e0233352. Epub 2020 May 22.

Department of Pediatrics, Division of Pediatric Pulmonary and Sleep Medicine, Children's National Medical Center, George Washington University, Washington, DC, United States of America.

Background: MicroRNAs (miRs) control gene expression and the development of the immune system and antiviral responses. MiR-155 is an evolutionarily-conserved molecule consistently induced during viral infections in different cell systems. Notably, there is still an unresolved paradox for the role of miR-155 during viral respiratory infections. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233352PLOS

Effects of nonlinear frequency compression on Mandarin speech and sound-quality perception in hearing-aid users.

Int J Audiol 2020 May 22:1-10. Epub 2020 May 22.

Division of Communication Sciences and Disorders, Ohio University, Athens, OH, USA.

The purpose of the present study was to examine the effects of NLFC fitting in hearing aids and auditory acclimatisation on speech perception and sound-quality rating in hearing-impaired, native Mandarin-speaking adult listeners. Mandarin consonant, vowel and tone recognition were tested in quiet and sentence recognition in noise (speech-shaped noise at a +5 dB signal-to-noise ratio) with NLFC-on and NLFC-off. Sound-quality ratings were collected on a 0-10 scale at each test session. Read More

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http://dx.doi.org/10.1080/14992027.2020.1761035DOI Listing

Somatic mutations of triple-negative breast cancer: a comparison between Black and White women.

Breast Cancer Res Treat 2020 May 21. Epub 2020 May 21.

Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Elm & Carlton Streets, Buffalo, NY, 14263, USA.

Purpose: Understanding the contribution of tumor genome biology to racial disparities of triple-negative breast cancer (TNBC) is important for narrowing the cancer mortality gap between Black and White women.

Methods: We evaluated tumor somatic mutations using targeted sequencing of a customized panel of 151 genes and 15 copy number variations (CNVs) within a population of 133 TNBC patients, including 71 Black and 62 White women.

Results: The overall mutational burden between Black and White women with TNBC was not significantly different, with a median of 5 somatic changes per patient (point mutations and CNVs combined) for the customized panel (range 1-31 for Blacks vs. Read More

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http://dx.doi.org/10.1007/s10549-020-05693-4DOI Listing

Assessing the Feasibility of an Online Training Designed to Enable Community Health Workers to Deliver a Comprehensive, Evidence-Based Weight Loss Intervention for Rural African Americans of Faith.

J Cancer Educ 2020 May 21. Epub 2020 May 21.

Department of Health Behavior and Health Education, University of Arkansas for Medical Sciences, 4301 West Markham, Little Rock, AR, 72205, USA.

Obesity is a critical modifiable risk factor in cancer prevention, control, and survivorship. Comprehensive weight loss interventions (e.g. Read More

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http://dx.doi.org/10.1007/s13187-020-01764-8DOI Listing

Nutritional habits and free grazing regimen of productive animals along with specific ingredients are influential factors for the antioxidant properties of milk: From farm to market.

Biomed Rep 2020 Jul 28;13(1):31-36. Epub 2020 Apr 28.

Department of Biochemistry and Biotechnology, University of Thessaly, 41500 Larissa, Greece.

Milk is a fundamental product of animal origin for human health and well-being. It possesses crucial biological properties, which depend on its composition and production methodology. To this end, one of the aims of the present study was to assess the impact of the nutritional and dwelling patterns of productive animals on the antioxidant potency of their generated milk. Read More

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http://dx.doi.org/10.3892/br.2020.1301DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238402PMC

Phenotypic and Genotypic Assessment of Antibiotic Resistance of Bacteria Isolated from Retail Meat.

Infect Drug Resist 2020 7;13:1339-1349. Epub 2020 May 7.

Department of Food Hygiene and Public Health, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran.

Background: Resistant () bacteria are determined to be one of the main causes of foodborne diseases.

Purpose: This survey was done to assess the genotypic and phenotypic profiles of antibiotic resistance of bacteria isolated from retail meat.

Methods: Four-hundred and eighty-five retail meat samples were collected and examined. Read More

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http://dx.doi.org/10.2147/IDR.S241189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7213866PMC

Distributed amylin receptor signaling and its influence on motivated behavior.

Physiol Behav 2020 May 18:112958. Epub 2020 May 18.

Exercise and Nutrition Sciences, School of Public Health and Health Professions,; Center for Ingestive Behavior Research, University at Buffalo, State University of New York, Buffalo, NY 14214, USA. Electronic address:

The intake- and body weight-suppressive hormone amylin exerts effects on energy balance control at a variety of nuclei within the brain, including sites that have been referred to in the literature as mediating homeostatic versus hedonic aspects of feeding. Here, we review key central nervous system sites of action for amylin signaling in the neural control of feeding and body weight, and discuss how these sites may interact to mediate the effects of amylin within the brain. Additionally, we review recent findings suggesting that amylin influences alcohol intake, suggesting broader effects of amylin on motivated behavior beyond feeding. Read More

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http://dx.doi.org/10.1016/j.physbeh.2020.112958DOI Listing

Managing Death in the Field: Prehospital End-of-life Care.

J Pain Symptom Manage 2020 May 10. Epub 2020 May 10.

University at Buffalo, Department of Emergency Medicine, 77 Goodell St. Suite 340, Buffalo, NY 14203.

Context: Historically, the focus of prehospital care has been life-saving treatment. Absent a Non-Hospital Do Not Resuscitate (NHDNR) order, prehospital providers have been compelled to begin and continue resuscitation unless or until it was certain that the situation was futile; they have faced conflict when caregivers objected.

Objectives: The purpose of the study was to explore prehospital providers' perspectives on how legally binding documents (NHDNR/Medical Orders for Life Sustaining Treatment [MOLST]) informed end-of-life decision-making and care. Read More

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http://dx.doi.org/10.1016/j.jpainsymman.2020.05.004DOI Listing

β2-adrenergic receptor activation on donor cells ameliorates acute GvHD.

JCI Insight 2020 May 21. Epub 2020 May 21.

Transplant and Cellular Therapy Program, Department of Medicine, Clinical Sciences Center, Roswell Park Comprehensive Cancer Center, Buffalo, United States of America.

Acute graft versus host disease (aGvHD) remains a major impediment to successful allogeneic hematopoietic cell transplantation (allo-HCT). To solve this problem, a greater knowledge of factors which regulate the differentiation of donor T cells toward cytotoxic or regulatory cells is necessary. We report that the β2-adrenergic receptor (β2-AR) is critical for regulating this differentiation, and that its manipulation can control aGvHD without impairing the graft-versus-tumor (GvT) effect. Read More

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http://dx.doi.org/10.1172/jci.insight.137788DOI Listing

Caffeine enhances sustained attention among adolescents.

Exp Clin Psychopharmacol 2020 May 21. Epub 2020 May 21.

Department of Psychology.

Despite the growing interest in caffeine use and its effects among adolescents, and a large literature on caffeine and attention among adults, there is a lack of experimental work examining the impact of caffeine on sustained attention among adolescents. We evaluated the acute effects of caffeine (vs. placebo) during a long (33-min) classic vigilance task among 31 adolescents (aged 12-17; 15 female; median caffeine use = 28 mg/day). Read More

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http://dx.doi.org/10.1037/pha0000364DOI Listing

Dehydroascorbic acid, the oxidized form of vitamin C, improves renal histology and function in old mice.

J Cell Physiol 2020 May 21. Epub 2020 May 21.

Center for Advanced Microscopy CMA BIO BIO, University of Concepcion, Concepcion, Chile.

Oxidative stress and inflammation are crucial factors that increase with age. In the progression of multiple age-related diseases, antioxidants and bioactive compounds have been recognized as useful antiaging agents. Oxidized or reduced vitamin C exerts different actions on tissues and has different metabolism and uptake. Read More

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http://dx.doi.org/10.1002/jcp.29791DOI Listing

Molecular Biological Features of Nottingham Histological Grade 3 Breast Cancers.

Ann Surg Oncol 2020 May 20. Epub 2020 May 20.

Department of Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA.

Introduction: Cancer biology dominates the behavior and prognosis of a tumor. Although Nottingham histological grade is a subjective pathological determination, it has been accepted as a surrogate model for cancer biology. As such, histologic grade was incorporated into the latest 8th edition of the American Joint Committee on Cancer breast cancer staging system. Read More

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http://dx.doi.org/10.1245/s10434-020-08608-1DOI Listing

A Participatory Investigation of Bovine Health and Production Issues in Pakistan.

Front Vet Sci 2020 6;7:248. Epub 2020 May 6.

Department of Veterinary Biosciences, Faculty of Veterinary and Agricultural Sciences, Melbourne Veterinary School, The University of Melbourne, Werribee, VIC, Australia.

Systems to record the frequency of animal health events in Pakistan are limited. A participatory approach was used to address gaps in farmers' knowledge and understanding of bovine health and production issues in five agroecological zones (AEZs) of Pakistan. Participatory tools, including simple ranking, pairwise ranking, constraint impact scoring, and constraint profiling were used in group discussions with farmers and animal health professionals (AHPs) in six districts of two provinces, Punjab and Sindh. Read More

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http://dx.doi.org/10.3389/fvets.2020.00248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218055PMC

Minimizing SARS-CoV-2 exposure when performing surgical interventions during the covid-19 pandemic.

J Neurointerv Surg 2020 May 20. Epub 2020 May 20.

Neurosurgery, Lenox Hill Hospital, New York, New York, USA.

Background: Infection from the SARS-CoV-2 virus has led to the covid-19 pandemic. Given the large number of patients affected, healthcare personnel and facility resources are stretched to the limit; however, the need for urgent and emergent neurosurgical care continues. This article describes best practices when performing neurosurgical procedures on patients with covid-19 based on multi-institutional experiences. Read More

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http://dx.doi.org/10.1136/neurintsurg-2020-016161DOI Listing

Linkage Disequilibrium-Based Inference of Genome Homology and Chromosomal Rearrangements Between Species.

G3 (Bethesda) 2020 May 20. Epub 2020 May 20.

Universidade Estadual Paulista (Unesp).

The aim of this study was to analyze the genomic homology between cattle () and buffaloes () and to propose a rearrangement of the buffalo genome through linkage disequilibrium analyses of buffalo SNP markers referenced in the cattle genome assembly and also compare it to the buffalo genome assembly. A panel of bovine SNPs (single nucleotide polymorphisms) was used for hierarchical, non-hierarchical and admixture cluster analyses. Thus, the linkage disequilibrium information between markers of a specific panel of buffalo was used to infer chromosomal rearrangement. Read More

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http://dx.doi.org/10.1534/g3.120.401090DOI Listing

Exposure-Response Analysis of Vamorolone (VBP15) in Boys With Duchenne Muscular Dystrophy.

J Clin Pharmacol 2020 May 20. Epub 2020 May 20.

Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York, USA.

Exposure-response relationships of vamorolone, a novel dissociative steroidal anti-inflammatory drug, were investigated in clinical trials in boys with Duchenne muscular dystrophy. Variables were clinical outcome measures, Fridericia-corrected QT (QTcF) duration, and pharmacodynamic (PD) biomarkers. Exposure metrics were area under the plasma concentration time curve (AUC) and maximum plasma concentration (C ), with a sigmoid E model applied. Read More

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http://dx.doi.org/10.1002/jcph.1632DOI Listing

Molecular and microscopic detection of natural and experimental infections of Toxocara vitulorum in bovine milk.

PLoS One 2020 20;15(5):e0233453. Epub 2020 May 20.

Department of Parasitology, Faculty of Veterinary Medicine, Alexandria University, Alexandria, Egypt.

Toxocara vitulorum is an Ascarid nematode infecting the small intestine of buffalo and cattle particularly neonate calves, with the postnatal route through milk is the main infection source. However, little is known about shedding rates and the optimum detection methods of T. vitulorum larvae in the milk of the infected bovine hosts. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233453PLOS

Management of Cancer Cachexia: ASCO Guideline.

J Clin Oncol 2020 May 20:JCO2000611. Epub 2020 May 20.

Mayo Clinic, Rochester, MN.

Purpose: To provide evidence-based guidance on the clinical management of cancer cachexia in adult patients with advanced cancer.

Methods: A systematic review of the literature collected evidence regarding nutritional, pharmacologic, and other interventions, such as exercise, for cancer cachexia. PubMed and the Cochrane Library were searched for randomized controlled trials (RCTs) and systematic reviews of RCTs published from 1966 through October 17, 2019. Read More

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http://dx.doi.org/10.1200/JCO.20.00611DOI Listing

TNFα and IL-17 Alkalinize Airway Surface Liquid through CFTR and Pendrin.

Am J Physiol Cell Physiol 2020 May 20. Epub 2020 May 20.

Department of Internal Medicine, Howard Hughes Medical Institute, Department of Molecular Physiology and Biophysics Roy J. and Lucille A. Carver College of Medicine University of Iowa, Iowa City, IA, USA.

The pH of airway surface liquid (ASL) is a key factor that determines respiratory host defense; ASL acidification impairs and alkalinization enhances key defense mechanisms. Under healthy conditions, airway epithelia secrete base (HCO) and acid (H) to control ASL pH (pH). Neutrophil-predominant inflammation is a hallmark of several airway diseases, and TNFα and IL-17 are key drivers. Read More

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http://dx.doi.org/10.1152/ajpcell.00112.2020DOI Listing

Safety of gemtuzumab ozogamicin as monotherapy or combination therapy in an expanded-access protocol for patients with relapsed or refractory acute myeloid leukemia.

Leuk Lymphoma 2020 May 20:1-9. Epub 2020 May 20.

Washington University Medical School, St. Louis, MO, USA.

Gemtuzumab ozogamicin (GO) remained available to US clinicians through an open-label expanded-access protocol (NCT02312037) until GO was reapproved. Patients were aged ≥3 months with relapsed/refractory (R/R) acute myeloid leukemia (AML), high-risk myelodysplastic syndrome, or acute promyelocytic leukemia (APL), and had exhausted other treatment options. Three hundred and thirty one patients received GO as monotherapy for R/R AML ( 139), combination therapy for R/R AML ( 183), or treatment for R/R APL ( 9). Read More

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http://dx.doi.org/10.1080/10428194.2020.1742897DOI Listing

Seroprevalence of Selected Tick Borne Pathogens and Diversity and Abundance of Ixodid Ticks (Acari: ) at the Wildlife-Livestock Interface in Northern Botswana.

Front Vet Sci 2020 5;7:187. Epub 2020 May 5.

Veterinary Sciences, Botswana University of Agriculture and Natural Resources, Gaborone, Botswana.

Ticks and tick borne diseases (TBDs) undermine livestock production with considerable economic losses to livestock producers in endemic areas worldwide. Despite the impact of ticks and TBDs in livestock production, there is a paucity of information on ticks and diseases they transmit in Botswana. To address this gap, a cross-sectional study was conducted to determine (i) the seroprevalence of selected tick borne (TB) pathogens and (ii) the diversity and abundance of ixodid ticks among 301 cattle foraging around two protected areas in northern Botswana, differing by the presence or absence of a physical barrier (fence) separating wildlife and livestock. Read More

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http://dx.doi.org/10.3389/fvets.2020.00187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214809PMC

A CNN-LSTM neural network for recognition of puffing in smoking episodes using wearable sensors.

Biomed Eng Lett 2020 May 30;10(2):195-203. Epub 2020 Jan 30.

1Department of Electrical and Computer Engineering, The University of Alabama, Tuscaloosa, AL 35487 USA.

A detailed assessment of smoking behavior under free-living conditions is a key challenge for health behavior research. A number of methods using wearable sensors and puff topography devices have been developed for smoking and individual puff detection. In this paper, we propose a novel algorithm for automatic detection of puffs in smoking episodes by using a combination of Respiratory Inductance Plethysmography and Inertial Measurement Unit sensors. Read More

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http://dx.doi.org/10.1007/s13534-020-00147-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235127PMC

Crystal structures of {1,1,1-tris-[(salicylaldimino)-meth-yl]ethane}-gallium as both a pyridine solvate and an aceto-nitrile 0.75-solvate and {1,1,1-tris[(salicylaldimino)-meth-yl]ethane}-indium di-chloro-methane solvate.

Acta Crystallogr E Crystallogr Commun 2020 May 3;76(Pt 5):615-620. Epub 2020 Apr 3.

Department of Chemistry, Buffalo State College, 1300 Elmwood Avenue, Buffalo, NY 14222, USA.

The sexa-dentate ligand 1,1,1-tris-[(salicyl-idene-amino)-meth-yl]ethane has been reported numerous times in its triply deprotonated form coordinated to transition metals and lanthanides, yet it has been rarely employed with main-group elements, including in substituted forms. Its structures with gallium and indium are reported as solvates, namely, ({[(2,2-bis-{[(2-oxido-benzyl-idene)amino-κ,]meth-yl}prop-yl)imino]-meth-yl}phenololato-κ,)gallium(III) pyridine monosolvate, [Ga(CHNO3)]·CHN, the aceto-nitrile 0.75-solvate, [Ga(CHNO)]·0. Read More

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http://dx.doi.org/10.1107/S2056989020004375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199255PMC

Impact of Marriage on Birth Outcomes: Pregnancy Risk Assessment Monitoring System, 2012-2014.

Linacre Q 2019 May 10;86(2-3):225-230. Epub 2019 May 10.

The State University of New York at Buffalo, Buffalo, NY, USA.

Marriage has been associated with improved pregnancy outcomes. However, as Americans become increasingly accepting of pregnancy and childbearing outside of marriage, many believe the father can support the mother without the parents being married. Some question whether the present normalization of childbearing outside of marriage will negate the protective effect of marriage on pregnancy outcomes. Read More

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http://dx.doi.org/10.1177/0024363919843019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6699055PMC

Two-year survey on the seasonal incidence of aflatoxin M1 in traditional dairy products in Egypt.

J Food Sci Technol 2020 Jun 20;57(6):2182-2189. Epub 2020 Jan 20.

2Department of Botany and Microbiology, Faculty of Science, Cairo University, Cairo, Egypt.

The most popular and economically important traditional dairy products in Egypt are raw milk, Karish cheese (an Arabian dairy product made from defatted cow milk) and Zabady (an Arabian yoghurt made from buffalo and cow milk). In this study, 302 traditional dairy samples including raw milk (120), white Karish cheese (118), and Zabady (64) were analyzed for aflatoxin M1 (AFM1) during different seasons in 2016 and 2017. Contamination of raw milk samples with AFM1 was 21. Read More

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http://dx.doi.org/10.1007/s13197-020-04254-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230085PMC

Creating a Film to Teach Health Professions Students the Importance of Interprofessional Collaboration.

Am J Pharm Educ 2020 Apr;84(4):7638

University at Buffalo, Office of the Vice President for Health Sciences, Buffalo, New York.

To produce, implement, and evaluate the effectiveness of a film to develop the foundational knowledge and skills of health professions students and teach them the importance of interprofessional collaboration. An existing interprofessional case study about a Hispanic man suffering from multiple chronic health conditions and the impact his health had on his family served as the basis for the film. To ensure a high-quality production, faculty members partnered with a local theatre company to produce the film. Read More

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http://dx.doi.org/10.5688/ajpe7638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223936PMC

Association Between Mothers' Alcohol Use Histories and Deficient Parenting in an Economically Disadvantaged Sample.

Child Maltreat 2020 May 20:1077559520925550. Epub 2020 May 20.

Department of Psychological and Brain Sciences, The University of Iowa, IA, USA.

Objective: Problematic maternal alcohol use confers risk for child maltreatment, though the effect on specific aspects of parenting is unclear. This study examined concurrent and prospective links among maternal alcohol use history, care neglect, supervisory neglect, and harsh or inconsistent discipline.

Method: Multimethod multisource data were utilized to assess deficient parenting in 311 economically disadvantaged mothers at high risk of child maltreatment. Read More

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http://dx.doi.org/10.1177/1077559520925550DOI Listing

Nanobowl-Supported Liposomes Improve Drug Loading and Delivery.

Nano Lett 2020 May 20. Epub 2020 May 20.

Hongqiao International Institute of Medicine, Tongren Hospital and State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.

Liposomal drug delivery for cancer therapy can be limited due to drug leakage in circulation. Here, we develop a new method to enhance the stability of actively loaded liposomal doxorubicin (DOX) through embedding a stiff nanobowl in the liposomal water cavity. Nanobowl-supported liposomal DOX (DOX@NbLipo) resists the influence of plasma protein and blood flow shear force to prevent drug leakage. Read More

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http://dx.doi.org/10.1021/acs.nanolett.0c00495DOI Listing

Checkpoint blockade treatment sensitises relapsed/refractory non-Hodgkin lymphoma to subsequent therapy.

Br J Haematol 2020 May 19. Epub 2020 May 19.

Perlmutter Cancer Center at NYU Langone Health, New York, NY, USA.

Patients with relapsed/refractory (R/R) non-Hodgkin lymphoma (NHL) have limited options for salvage, and checkpoint blockade therapy (CBT) has little efficacy. Usage in solid malignancies suggests that CBT sensitises tumours to subsequent chemotherapy. We performed the first analysis of CBT on subsequent NHL treatment. Read More

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http://dx.doi.org/10.1111/bjh.16756DOI Listing

Nutraceutical and Technological Properties of Buffalo and Sheep Cheese Produced by the Addition of Kiwi Juice as a Coagulant.

Foods 2020 May 15;9(5). Epub 2020 May 15.

Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, 56124 Pisa, Italy.

Kiwifruit is an interesting alternative to chymosin for milk coagulation. Although the clotting properties of actinidin (the proteolytic agent present in kiwi) have been widely investigated, little is known about the nutraceutical and organoleptic effects of kiwifruit on the characteristics of cheese. We investigated kiwifruit pulp, compared to calf rennet, in cheesemaking using sheep and buffalo milk. Read More

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http://dx.doi.org/10.3390/foods9050637DOI Listing

Interobserver Agreement for the International Academy of Cytology Yokohama System for Reporting Breast Fine-Needle Aspiration Biopsy Cytopathology.

Acta Cytol 2020 May 19:1-7. Epub 2020 May 19.

University of Utah Health Care and ARUP Laboratories, Salt Lake City, Utah, USA.

Background: A number of guidelines have been developed to improve standardization of the terminology and criteria for cytologic specimens obtained from the thyroid, pancreas, lung, and salivary glands. A major goal of these guidelines is to improve reproducibility and understanding of the reporting of diagnostic results among cytopathologists and between cytopathologists and clinicians. The International Academy of Cytology Yokohama System for Reporting Breast Fine-Needle Aspiration Biopsy Cytopathology (IAC YSRB) is the most recent of these guidelines. Read More

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http://dx.doi.org/10.1159/000506757DOI Listing

Trait specific modulatory effects of caffeine exposure on compulsive-like behaviors in a spontaneous mouse model of obsessive-compulsive disorder.

Behav Pharmacol 2020 May 13. Epub 2020 May 13.

Department of Biology & Wildlife, University of Alaska Fairbanks, Fairbanks, Alaska, USA.

Obsessive-compulsive disorder (OCD) is a psychiatric disorder characterized by recurring intrusive thoughts and repetitive compulsive behaviors, ultimately interfering with their quality of life. The complex heterogeneity of symptom dimensions across OCD patient subgroups impedes diagnosis and treatment. The core and comorbid symptomologies of OCD are thought to be modulated by common environmental exposures such as consumption of the psychostimulant caffeine. Read More

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http://dx.doi.org/10.1097/FBP.0000000000000570DOI Listing

MUC1-C drives stemness in progression of colitis to colorectal cancer.

JCI Insight 2020 May 19. Epub 2020 May 19.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard University, Boston, United States of America.

Colitis is associated with the development of colorectal cancer (CRC) by largely undefined mechanisms that are critical for understanding the link between inflammation and cancer. Intestinal stem cells (ISCs) marked by LGR5 expression are of importance in both the inflammatory response to colitis and progression to colitis-associated colon cancer (CACC). Here, we report in human MUC1-transgenic mouse models of CACC that targeting the MUC1-C oncogenic protein, which is upregulated in inflammation, suppresses the (i) Lgr5+ ISC population, (ii) induction of Myc and core pluripotency stem cell factors, and (iii) severity and progression of colitis to dysplasia and cancer. Read More

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http://dx.doi.org/10.1172/jci.insight.137112DOI Listing

Contribution of Germline Predisposition Gene Mutations to Breast Cancer Risk in African American Women.

J Natl Cancer Inst 2020 May 19. Epub 2020 May 19.

Departments of Health Sciences Research, Laboratory Medicine and Pathology, and Oncology, Mayo Clinic, Rochester, MN 55902, USA.

Background: The risks of breast cancer in African American (AA) women associated with inherited mutations in breast cancer predisposition genes are not well defined. Thus, whether multigene germline hereditary cancer testing panels are applicable to this population is unknown. We assessed associations between mutations in panel-based genes and breast cancer risk in 5054 AA women with breast cancer and 4993 unaffected AA women drawn from 10 epidemiologic studies. Read More

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http://dx.doi.org/10.1093/jnci/djaa040DOI Listing

The Role of past and Current Medical Use on Nonmedical Use of Prescription Drugs among College Students: Exploring Same-Drug and Cross-Drug Class Associations.

Subst Use Misuse 2020 May 19:1-6. Epub 2020 May 19.

Department of Psychology, State University of New York at Albany, Albany, New York, USA.

: Understanding the role that medical use of prescription drugs plays in nonmedical use of prescription drugs can inform prevention efforts. In order to understand fully the potential risk that medical use of prescription drugs conveys for nonmedical use of prescription drugs, the current study explored (a) the simultaneous associations between the medical use of several classes of prescription drugs with current nonmedical use of the same and other prescription drug classes, and (b) whether the associations depended upon past or current medical use. : Data came from a cross-sectional survey of 1686 college students, which assessed past and current medical use and current nonmedical use of stimulants, sedatives/anxiolytics, and opioid analgesics. Read More

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http://dx.doi.org/10.1080/10826084.2020.1762651DOI Listing

An Attacker-defender Resource Allocation Game with Substitution and Complementary Effects.

Risk Anal 2020 May 19. Epub 2020 May 19.

Department of Industrial and Systems Engineering, University at Buffalo, Buffalo, NY, USA.

The United States is funding homeland security programs with a large budget (e.g., 74. Read More

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http://dx.doi.org/10.1111/risa.13483DOI Listing

Impact of a Multidisciplinary Sepsis Initiative on Knowledge and Behavior in a Pediatric Center.

Pediatr Qual Saf 2020 Mar-Apr;5(2):e267. Epub 2020 Mar 10.

Division of Pediatric Critical Care Medicine, Department of Pediatrics, John R. Oishei Children's Hospital, Buffalo, N.Y.

Objective: Our institution performed an educational initiative targeting previously identified barriers to pediatric sepsis recognition and treatment. We hypothesized that provider knowledge, attitude, and behavior would be improved 1 year after implementation.

Methods: This was a prospective, observational study of a multi-faceted quality initiative introduced to providers in the Emergency Department, inpatient wards, and Pediatric Intensive Care Unit of a tertiary care children's hospital. Read More

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http://dx.doi.org/10.1097/pq9.0000000000000267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190264PMC

Transient inhibition of mTOR in human pluripotent stem cells enables robust formation of mouse-human chimeric embryos.

Sci Adv 2020 May 13;6(20):eaaz0298. Epub 2020 May 13.

Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY 14203, USA.

It has not been possible to generate naïve human pluripotent stem cells (hPSCs) that substantially contribute to mouse embryos. We found that a brief inhibition of mTOR with Torin1 converted hPSCs from primed to naïve pluripotency. The naïve hPSCs were maintained in the same condition as mouse embryonic stem cells and exhibited high clonogenicity, rapid proliferation, mitochondrial respiration, X chromosome reactivation, DNA hypomethylation, and transcriptomes sharing similarities to those of human blastocysts. Read More

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http://dx.doi.org/10.1126/sciadv.aaz0298DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220352PMC

Computational disease progression modeling can provide insights into cancer evolution.

Oncoscience 2020 Mar 1;7(3-4):21-22. Epub 2020 May 1.

Department of Microbiology and Immunology, The State University of New York, Buffalo, NY, USA.

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http://dx.doi.org/10.18632/oncoscience.501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217135PMC