3,375 results match your criteria Buerger Disease Thromboangiitis Obliterans


Identifying quality markers of Mailuoshutong pill against thromboangiitis obliterans based on chinmedomics strategy.

Phytomedicine 2022 Sep 2;104:154313. Epub 2022 Jul 2.

Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Jianshe East Road 1, Zhengzhou 450052, China; Henan Engineering Research Center of Clinical Mass Spectrometry for Precision Medicine, Zhengzhou Key Laboratory of Clinical Mass Spectrometry, Jianshe East Road 1, Zhengzhou 450052, China. Electronic address:

Background: Mailuoshutong pill (MLSTP) is a traditional Chinese medicine (TCM) for the treatment of Thromboangiitis obliterans (TAO, Buerger's disease) which is a segmental non-atherosclerotic inflammatory occlusive disorder. However, the mechanism and quality standards of MLSTP have not been sufficiently studied.

Purpose: This work aims to investigate the potential mechanisms and quality markers (Q-markers) of MLSTP treating TAO based on the chinmedomics strategy. Read More

View Article and Full-Text PDF
September 2022

Clinical outcomes in patients with infrapopliteal arterial occlusive disease treated by lower extremity bypass surgery: a comparison of atherosclerosis and thromboangiitis obliterans.

Eur Rev Med Pharmacol Sci 2022 06;26(12):4228-4237

Department of Vascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Objective: Surgical bypasses are commonly utilized for the treatment of infrapopliteal arterial occlusive disease resulting from atherosclerosis (ASO) and thromboangiitis obliterans (TAO), especially when endovascular procedures fail. The aim of this study is to compare the in-hospital and follow-up outcomes of ASO and TAO patients treated with infrapopliteal bypass surgery.

Patients And Methods: A total of 32 infrapopliteal bypasses were analyzed in 18 TAO patients and 14 ASO patients. Read More

View Article and Full-Text PDF

Thromboangiitis obliterans successfully treated with radius transverse transport.

Asian J Surg 2022 Jun 23. Epub 2022 Jun 23.

Department of Orthopaedics, Guangdong Second Provincial General Hospital, Guangzhou, 510317, China. Electronic address:

View Article and Full-Text PDF

A Rare Case of Thromboangiitis Obliterans of Bilateral Upper Extremities in an Adult Male.

Cureus 2022 May 13;14(5):e24975. Epub 2022 May 13.

Internal Medicine, Lala Lajpat Rai (LLR) Hospital, Kanpur, IND.

Thromboangiitis obliterans (TAO) also known as Buerger's disease is a nonatherosclerotic vasculitis that is more common in adult male smokers. TAO predominantly affects lower extremities, however, cases with bilateral upper extremities involvement are a rare entity and difficult to manage. Symptoms of the disease mostly mimic that of acute ischemia of the limb. Read More

View Article and Full-Text PDF

Safety and Effectiveness of Excimer Laser Ablation Combined With Drug-Coated Balloon for Atherosclerotic Obliterans in the Lower Extremity.

J Endovasc Ther 2022 May 6:15266028221092979. Epub 2022 May 6.

Department of Vascular Surgery, Institute of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Purpose: To evaluate the safety and effectiveness of excimer laser ablation (ELA) combined with drug-coated balloon (DCB) for atherosclerotic obliterans (ASO) of the lower extremities.

Materials And Methods: From June 2019 to December 2020, all eligible patients were enrolled. Demographics, characteristics of lesions, complications, and follow-up information were collected and analyzed. Read More

View Article and Full-Text PDF

Cannabis arteritis: A case report and brief review of the literature.

Ann Med Surg (Lond) 2022 Apr 28;76:103523. Epub 2022 Mar 28.

Department of Vascular Surgery, Mohammed VI University Hospital of Oujda, Mohammed First University of Oujda, Morocco.

Introduction: Cannabis is commonly misused psychoactive drug which is known to be associated with a number of psychotic and somatic side-effects. Cannabis arteritis is a rare vascular disorder, since only about fifty cases have been reported in the literature.

Case Presentation: We report a case of a 40-year-old chronic cannabis user male, who was admitted for painful necrosis of the fifth toe of the right foot. Read More

View Article and Full-Text PDF

Thromboangiitis obliterans in pregnancy - Case report and literature review.

Obstet Med 2022 Mar 4;15(1):68-70. Epub 2021 Jan 4.

Department of Obstetric Medicine, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.

Thromboangiitis obliterans, also known as Buerger's disease, is rarely reported in young women in pregnancy. It is an occlusive vascular disorder, characterised by episodic non-atherosclerotic thrombosis of small- and medium-sized blood vessels. Thromboangiitis obliterans predominantly occurs in males aged less than 50 years and is almost exclusively diagnosed in smokers. Read More

View Article and Full-Text PDF

Nails Involvement in Winiwarter-Buerger Disease.

Skin Appendage Disord 2022 Mar 21;8(2):142-145. Epub 2021 Sep 21.

Department of Specialized, Experimental and Diagnostic Medicine, Dermatology-IRCCS, Policlinico Sant'Orsola, Alma Mater Studiorum, University of Bologna, Bologna, Italy.

Introduction: Buerger disease, or thromboangiitis obliterans, is an inflammatory and occlusive process involving small and medium size arteries and veins, which generally affects the lower limbs of young adult male with the habit of smoking.

Case Presentation: This paper reports 2 patients who developed nail lesions as the first sign of Buerger disease.

Conclusion: Signs and symptoms of Buerger's disease are secondary to the inflammatory process and arterial occlusion which results in severe ischemia. Read More

View Article and Full-Text PDF

Buerger's Disease May be a Chronic Rickettsial Infection with Superimposed Thrombosis: Literature Review and Efficacy of Doxycycline in Three Patients.

Infect Chemother 2022 Mar;54(1):20-58

Department of Microbiology, Inha University, Incheon, Korea.

Buerger's disease (BD) is a chronic inflammatory vasculitis of unknown etiology. The infectious etiology of BD was proposed by Buerger in 1914. Furthermore, there are scattered reports insisting that BD may be related to rickettsial infection, first asserted by Goodman since 1916, followed by Giroud and other French investigators from the 1940s through the 1960s, Nicolau in the 1960s, Bartolo (1980s), and Fazeli (2010s). Read More

View Article and Full-Text PDF

Ocular Manifestations of Buerger's Disease - A Review of Current Knowledge.

Clin Ophthalmol 2022 18;16:851-860. Epub 2022 Mar 18.

Department of Ophthalmology, Wroclaw Medical University, Wrocław, Poland.

Buerger's disease, also known as thromboangiitis obliterans, is a disorder of primarily small and medium arteries and veins of the arms and legs. We have failed to find a comprehensive review discussing a possible link between the disease and the eyes. The aim of this study is to review current knowledge on the topic of ocular manifestations in the course of Buerger's disease. Read More

View Article and Full-Text PDF

Endovascular Excimer Laser-Assisted Balloon Angioplasty for Infrapopliteal Arteries in Thromboangiitis Obliterans: A Treatment for Acute-Phase TAO.

Front Cardiovasc Med 2022 4;9:831340. Epub 2022 Mar 4.

Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.

Background: Thromboangiitis obliterans (TAO, Buerger's disease) is an inflammatory and obstructive vasculopathy, which leads to limb ischemic rest pain and ulcerations in the acute stage.

Objectives: This study aimed to assess the feasibility of excimer laser-assisted balloon angioplasty (BA) for patients with acute infrapopliteal TAO.

Method: This was a single-center retrospective cohort study. Read More

View Article and Full-Text PDF

Therapeutic Effect and Mechanism of Si-Miao-Yong-An-Tang on Thromboangiitis Obliterans Based on the Urine Metabolomics Approach.

Front Pharmacol 2022 22;13:827733. Epub 2022 Feb 22.

National Engineering Laboratory for the Development of Southwestern Endangered Medicinal Materials, Guangxi Botanical Garden of Medicinal Plant, Nanning, China.

Si-Miao-Yong-An-Tang (SMYAT) is a classic prescription for the treatment of thromboangiitis obliterans (TAO). However, the effect and mechanism are still unclear. This experiment aims to evaluate the therapeutic effect and mechanism of SMYAT on sodium laurate solution induced thromboangiitis obliterans model rats using urine metabolomics. Read More

View Article and Full-Text PDF
February 2022

Clinical Presentation and Treatment of Thromboangiitis Obliterans With Superimposed Osteomyelitis.

Cureus 2022 Jan 19;14(1):e21423. Epub 2022 Jan 19.

Anesthesiology, Aventura Hospital and Medical Center, Aventura, USA.

Thromboangiitis obliterans (TAO) is an autoimmune vasculitis that typically presents in male smokers between the ages of 25 and 40. Although TAO primarily affects medium-sized blood vessels, it can also infiltrate small blood vessels as well as nerves and veins. The inflammation can cause segmental thrombosing and occlusion of the blood vessels leading to gangrene and eventual amputations. Read More

View Article and Full-Text PDF
January 2022

Estimate and Temporal Trends of Buerger Disease Hospitalizations in the United States.

Am J Cardiol 2022 04 12;169:158-160. Epub 2022 Feb 12.

Department of Medicine, Weill Cornell Medicine-Qatar, Doha, Qatar. Electronic address:

View Article and Full-Text PDF

[Pathohistological characteristics of muscles in patients with chronic lower limb ischemia].

Arkh Patol 2022 ;84(1):5-13

Kazan (Volga) Federal University, Kazan, Russia.

Despite the widespread occurrence of ischemic diseases of the lower extremities, including atherosclerosis and diseases with an autoimmune component of their pathogenesis, the pathohistological signs of damage and concomitant chronic ischemia, compensatory tissue responses as intracellular and cellular regeneration remain out of the field of vision in researchers.

Objective: To assess the signs of damage (the extent of necrosis and apoptosis, capillary density (CD)) and regeneration (the cross-sectional muscle fiber area (CSMFA), the proportion of centrinucleated muscle fibers (CNMFs), and that of connective tissue), by using the gastrocnemius medial head biopsy specimens obtained from patients with heterogeneous forms of chronic lower limb obliterating diseases (CLLODs).

Subjects And Methods: The investigation included the biopsy specimens obtained from 44 men under 65 years of age (their mean age was 54±9. Read More

View Article and Full-Text PDF
February 2022

Acute phase reactant proteins in Buerger's disease: Is it a systemic disease?

Vascular 2022 Jan 20:17085381211069715. Epub 2022 Jan 20.

Immunology Research Center, Inflammation and Inflammatory Diseases Division, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

The aim of this study was evaluating acute phase reactant (APR) proteins including high sensitivity C-reactive protein (hsCRP), pentraxin 3 (PTX3), fibrinogen, complement C3, hepcidin, and albumin in patients suffering from Buerger's disease (BD) compared to controls. The APRs were evaluated in 92 cases of BD patients and 90 healthy age and sex matched controls of blood from Iran and Turkey. The diagnosis was done according to Shionoya's criteria. Read More

View Article and Full-Text PDF
January 2022

Long-term outcomes of large artery thromboangiitis obliterans and comparison with small artery thromboangiitis obliterans.

Medicine (Baltimore) 2022 Jan;101(1):e28512

Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.

Abstract: Although the distribution of arterial involvement is still the subject of controversy for defining the diagnostic criteria for thromboangiitis obliterans (TAO), several reports have described TAO involving the more proximal arterial segment. This study aimed to investigate the clinical characteristics and outcomes of large artery TAO in comparison with those of small artery TAO.Between January 2007 and July 2019, 83 consecutive symptomatic patients with a diagnosis of lower extremity TAO were stratified according to the most proximal arterial involvement, with the cutoff level of the adductor canal as a reference (large artery TAO versus small artery TAO), and analyzed retrospectively. Read More

View Article and Full-Text PDF
January 2022

Infection Associated With Thromboangiitis Obliterans-like Phenomena With Digital Autoamputation: A Case Report and Review of Q Fever-Associated Autoimmunity.

Open Forum Infect Dis 2022 Jan 16;9(1):ofab637. Epub 2021 Dec 16.

Division of Infectious Diseases, University of Colorado Denver, Anschutz Medical Campus, Denver, Colorado, USA.

We present a case of a patient with chronic Q fever who presented with digital necrosis, autoamputations, and positive anticentromere antibody, mimicking a scleroderma vasculopathy or thromboangiitis obliterans. infection has long been associated with the presence of autoantibodies and autoimmune phenomena including vasculitis. Clinicians should consider Q fever testing in patients with new-onset autoimmune diseases or autoantibodies and appropriate exposure histories. Read More

View Article and Full-Text PDF
January 2022

Personalized Cell Therapy for Patients with Peripheral Arterial Diseases in the Context of Genetic Alterations: Artificial Intelligence-Based Responder and Non-Responder Prediction.

Cells 2021 11 23;10(12). Epub 2021 Nov 23.

Shonan Research Institute of Innovative Medicine, Shonan Kamakura General Hospital, 1-1370 Okamoto, Kamakura 2478533, Japan.

Stem/progenitor cell transplantation is a potential novel therapeutic strategy to induce angiogenesis in ischemic tissue, which can prevent major amputation in patients with advanced peripheral artery disease (PAD). Thus, clinicians can use cell therapies worldwide to treat PAD. However, some cell therapy studies did not report beneficial outcomes. Read More

View Article and Full-Text PDF
November 2021

[Application of Rotarex mechanical thrombectomy system in acute lower limb ischemia].

Beijing Da Xue Xue Bao Yi Xue Ban 2021 Dec;53(6):1159-1162

Department of Intervention Vascular Surgery, Peking University Third Hospital, Beijing 100191, China.

Objective: To evaluate the effectiveness and safety of Rotarex mechanical thrombectomy system in treating acute lower limb ischemia.

Methods: From December 2017 to December 2019, the clinical data of 23 acute lower limb ischemia cases treated with Rotarex mechanical thrombectomy system were retrospectively analyzed. There were 14 males and 9 females from 53- to 84-year-old patients and the mean age was (69. Read More

View Article and Full-Text PDF
December 2021

The historical differential diagnosis of the disease that afflicted Aleijadinho, the famous 18th century Brazilian sculptor.

Arq Neuropsiquiatr 2021 12;79(12):1138-1144

Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Rio de Janeiro RJ, Brazil.

Background: The famous Brazilian Baroque sculptor named Antônio Francisco Lisboa, known as "Aleijadinho" (1738-1814), suffered from a deforming disease of the lower and upper limbs. The condition was characterized by atrophy, paresis and amputation. His face was also affected, with inflammation of the eyelids, deviation of the labial commissure, drooping of the chin and lower lip, giving him a sinister expression. Read More

View Article and Full-Text PDF
December 2021

[Revascularization of the deep femoral artery and its inflow vessels to treat critical limb ischemia in patients with thromboangiitis obliterans:a report of 9 cases].

Zhonghua Wai Ke Za Zhi 2021 Dec;59(12):980-986

Department of Vascular Surgery, the First Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100080, China.

To examine the effectiveness of revascularization of the deep femoral artery and its inflow vessels to treat critical limb ischemia in patients with thromboangiitis obliterans (TAO). The clinical data of 9 TAO patients with critical limb ischemia who underwent deep femoral artery and its inflow revascularization from January 2018 to October 2020 at Department of Vascular Surgery, the First Medical Center, People's Liberation Army General Hospital were retrospectively analyzed.There were all males, aged from 26 to 50 years with onset time from 1 to 7 years. Read More

View Article and Full-Text PDF
December 2021

Integrated analysis of long non-coding RNA-microRNA-mRNA competing endogenous RNAregulatory networks in thromboangiitis obliterans.

Bioengineered 2021 12;12(2):12023-12037

Department of Vascular Surgery, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China.

Thromboangiitis obliterans (TAO) is a non-atherosclerotic, segmental, chronic vascular inflammatory disease. Our aim was to explore the underlying mechanisms of long non-coding RNA (lncRNA)-related competing endogenous RNAs (ceRNAs) in TAO. Six blood samples were collected from patients with TAO and healthy individuals (three for each category). Read More

View Article and Full-Text PDF
December 2021

Integration of traditional Chinese medicine and nibble debridement and dressing method reduces thrombosis and inflammatory response in the treatment of thromboangiitis obliterans.

Ann Transl Med 2021 Sep;9(18):1413

Science and Education Section, Guangzhou Hospital of Traditional Chinese Medicine, Guangzhou, China.

Background: Thromboangiitis obliterans (TAO), also known as Buerger's disease, is an occlusive arterial disease; however, the pathogenesis of TAO is still unclear. Research has shown that traditional Chinese medicine (TCM) has significant advantages in the treatment of TAO. Our purpose was to explore the underlying roles of TCM in combination with nibble debridement and dressing method (NDDM) in a TAO rat model. Read More

View Article and Full-Text PDF
September 2021

Recent Updates and Advances in Winiwarter-Buerger Disease (Thromboangiitis Obliterans): Biomolecular Mechanisms, Diagnostics and Clinical Consequences.

Diagnostics (Basel) 2021 Sep 22;11(10). Epub 2021 Sep 22.

Unit of Clinical Biochemistry, Department of Biomolecular Sciences, Section of Biochemistry and Biotechnology, University "Carlo Bo" of Urbino, 61029 Urbino, Italy.

Thromboangiitis obliterans (TAO) or Buerger's disease is a segmental inflammatory, thrombotic occlusive peripheral vascular disease with unknown aetiology that usually involves the medium and small-sized vessels of young male smokers. Due to its unknown aetiology and similarities with atherosclerosis and vasculitis, TAO diagnosis is still challenging. We aimed to review the status of biomolecular and laboratory para-clinical markers in TAO compared to atherosclerosis and vasculitis. Read More

View Article and Full-Text PDF
September 2021

Application of nanofat grafting to rescue a severe ischaemic hand with thromboangiitis obliterans: A case report about promising salvage procedure.

Medicine (Baltimore) 2021 Oct;100(42):e27577

Division of Plastic Surgery, Department of Surgery, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan.

Rationale: Currently, there is no consensus regarding the best treatment for patients with thromboangiitis obliterans (TAO). Regenerative medicine, such as bone marrow stem cells or adipose-derived stem cell (ASC) transplantation, have proven efficacy in improving tissue perfusion and wound healing in clinical trials. In this case, we used nanofat grafting to treat severe conditions in a patient with TAO, with promising outcomes. Read More

View Article and Full-Text PDF
October 2021

The Preliminary Outcome of Laser-Assisted Angioplasty Combined with Endovascular Radiofrequency Ablation for Thromboangiitis Obliterans.

Adv Ther 2021 12 22;38(12):5700-5709. Epub 2021 Oct 22.

Department of Vascular Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.

Introduction: Endovascular therapies have not yet had an ideal effect on thromboangiitis obliterans (TAO) and no data have been published about laser-assisted angioplasty (LA) combined with radiofrequency ablation (RFA) for TAO. This study aimed to investigate the outcome of LA combined with RFA for TAO.

Methods: Sixteen consecutive patients underwent LA and RFA procedures between June 2018 and March 2019 in this prospective pilot study. Read More

View Article and Full-Text PDF
December 2021

Atypical Young-onset Dementia in Cerebral Thromboangiitis Obliterans: A Case Report.

Alzheimer Dis Assoc Disord 2022 Apr-Jun 01;36(2):168-172. Epub 2021 Sep 30.

Forensic Medicine, Pusan National University School of Medicine, Yangsan, Republic of Korea.

Young-onset dementia (YOD, age at onset below 45 y) has a broad differential diagnosis. We describe a 41-year-old man with atypical manifestations of YOD syndrome in cerebral thromoboangiitis obliterans (CTAO). Extensive antemortem workup including clinical assessment, laboratory investigations, neuroimaging, and genetic testing did not elucidate a diagnosis. Read More

View Article and Full-Text PDF
September 2021

Differences in autoimmunity factors based on the activity of thromboangiitis obliterans.

Turk Kardiyol Dern Ars 2021 Sep;49(6):439-447

Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Objective: The treatment of Buerger's disease (BD) presents a medical problem as its etiology is still unclear. In this study, our objective was to evaluate the serum levels of autoimmune markers in patients with different clinical features of BD.

Methods: In this study, 80 BD patients were categorized in three groups using a cross-sectional design: migratory thrombophlebitis, cold sensitivity, and skin discoloration (mild symptoms); chronic ulcers, claudication, and burning pain of the feet at night (moderate symptoms); pain at rest and spontaneous gangrene (severe symptoms). Read More

View Article and Full-Text PDF
September 2021

Phase IV postmarketing surveillance study shows continued efficacy and safety of Stempeucel in patients with critical limb ischemia due to Buerger's disease.

Stem Cells Transl Med 2021 12 13;10(12):1602-1613. Epub 2021 Sep 13.

Stempeutics Research Pvt. Ltd, Bangalore, India.

Buerger's disease or thromboangiitis obliterans is a type of obstructive vascular diseases categorized as vasculitis and usually present in 95% of young smoker men. The main pathogenetic mechanism is interplay between immune system and inflammation. Earlier our phase II study has shown that Stempeucel is safe when injected at 2 million cells/kg body weight by virtue of its anti-inflammatory, immunomodulatory, and angiogenetic properties. Read More

View Article and Full-Text PDF
December 2021