3,242 results match your criteria Buerger Disease Thromboangiitis Obliterans


Thromboangiitis Obliterans: 110 Years Old and Little Progress Made.

Authors:
Jeffrey W Olin

J Am Heart Assoc 2018 Dec;7(23):e011214

1 Zena and Michael A. Wiener Cardiovascular Institute & Marie-Jose'e and Henry R. Kravis Center for Cardiovascular Health Icahn School of Medicine at Mount Sinai New York NY.

See Article by Le Joncour et al . Read More

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http://dx.doi.org/10.1161/JAHA.118.011214DOI Listing
December 2018

Long-Term Outcome and Prognostic Factors of Complications in Thromboangiitis Obliterans (Buerger's Disease): A Multicenter Study of 224 Patients.

J Am Heart Assoc 2018 Dec;7(23):e010677

1 UPMC Univ Paris 06 UMR 7211, and Inflammation-Immunopathology-Biotherapy Department (DHU i2B) Sorbonne Universités Paris France.

Background Data regarding long-term outcome of patients with thromboangiitis obliterans are lacking and most series come from India and Japan. In this study, we assess long-term outcome and prognostic factors in a large cohort of thromboangiitis obliterans. Methods and Results Retrospective multicenter study of characteristics and outcomes of 224 thromboangiitis obliterans patients fulfilling Papa's criteria were analyzed. Read More

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http://dx.doi.org/10.1161/JAHA.118.010677DOI Listing
December 2018
4 Reads

Effects of aspirin combined with cilostazol on thromboangiitis obliterans in diabetic patients.

Exp Ther Med 2018 Dec 8;16(6):5041-5046. Epub 2018 Oct 8.

Department of Blood Transfusion, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.

The present study explored the effects of aspirin combined with cilostazolin in the treatment of diabetic patients with thromboangiitis obliterans and the effects on the related inflammatory factors. A total of 90 diabetic patients with thromboangiitis obliterans admitted to Weifang People's Hospital from August 2015 to June 2017 were selected and divided into the control group (n=45) and the combination group (n=45). Patients in the control group were given aspirin, and those in the combination group were given aspirin combined with cilostazol. Read More

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http://dx.doi.org/10.3892/etm.2018.6833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256971PMC
December 2018
1 Read

Performance of noninvasive laser Doppler flowmetry and laser speckle contrast imaging methods in diagnosis of Buerger disease: A case report.

Medicine (Baltimore) 2018 Oct;97(43):e12979

Department of Vascular Medicine, Rennes University Hospital, Rennes.

Rationale: Buerger disease (BD) is a nonatherosclerotic, inflammatory, segmental vascular occlusive disease, which affects small and medium-sized arteries and veins and is triggered by substantial tobacco exposure. Angiographic findings consistent with BD are required for diagnosis. Laser Doppler flowmetry (LDF) and laser speckle contrast imaging (LSCI) could represent potential noninvasive alternative techniques to angiography. Read More

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http://dx.doi.org/10.1097/MD.0000000000012979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221735PMC
October 2018
14 Reads

Stem cell therapy for treatment of thromboangiitis obliterans (Buerger's disease).

Cochrane Database Syst Rev 2018 10 31;10:CD012794. Epub 2018 Oct 31.

Division of Vascular and Endovascular Surgery, Department of Surgery, UNIFESP - Escola Paulista de Medicina, Rua Borges Lagoa, 564 cj 124, Vila Clementino, São Paulo, Brazil, 04038000.

Background: Thromboangiitis obliterans, also known as Buerger's disease, is a non-atherosclerotic, segmental inflammatory pathology that most commonly affects the small- and medium-sized arteries, veins, and nerves in the upper and lower extremities. The etiology is unknown, but involves hereditary susceptibility, tobacco exposure, immune and coagulation responses. In many cases, there is no possibility of revascularization to improve the condition. Read More

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http://dx.doi.org/10.1002/14651858.CD012794.pub2DOI Listing
October 2018
16 Reads

Thromboangiitis obliterans episode: autoimmune flare-up or reinfection?

Vasc Health Risk Manag 2018 28;14:247-251. Epub 2018 Sep 28.

Immunology Research Center, Inflammation and Inflammatory Diseases Division, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran,

Background: The possible role of infectious pathogens in the development of thromboangiitis obliterans (TAO) was considered soon after the disease was first described. However, it is not yet known whether infectious pathogens induce thrombotic vasculitis or if they cause a type of autoimmune disease. To investigate whether TAO relapses are more likely due to reinfection or autoimmune flare, the serum levels of toll-like receptor (sTLR) 4, sTLR2, C-reactive protein (CRP), and neopterin were evaluated in TAO patients during both the acute and quiescent phases of the disease as well as in a gender-, age-, and smoking habit-matched control group. Read More

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http://dx.doi.org/10.2147/VHRM.S172047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6168068PMC
November 2018
5 Reads

Outcomes of endovascular treatment versus bypass surgery for critical limb ischemia in patients with thromboangiitis obliterans.

PLoS One 2018 9;13(10):e0205305. Epub 2018 Oct 9.

Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea.

We aimed to compare the clinical outcomes between endovascular treatment and inframalleolar bypass surgery for critical limb ischemia (CLI) in patients with thromboangiitis obliterans (TAO) and to assess the role of bypass surgery in the era of innovative endovascular treatment. Between January 2007 and December 2017, a total of 33 consecutive patients with the diagnosis of TAO presenting with CLI who underwent endovascular treatment (endovascular group, n = 22) or bypass surgery to the pedal or plantar vessels (bypass group, n = 11) were included and analyzed retrospectively. The primary endpoint was defined as a major amputation of the index limb, and the secondary endpoint was defined as graft occlusion, regardless of the number of subsequent procedures. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205305PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177182PMC
October 2018
4 Reads

Alleviation of A disintegrin and metalloprotease 10 (ADAM10) on thromboangiitis obliterans involves the HMGB1/RAGE/ NF-κB pathway.

Biochem Biophys Res Commun 2018 Oct 20;505(1):282-289. Epub 2018 Sep 20.

Department of Vascular Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, China. Electronic address:

Thromboangiitis obliterans (TAO), also known as Buerger's disease, is a nonatherosclerotic inflammatory disease that influences medium- and small-sized blood vessels of extremities. However, mechanisms underlying TAO are still unclear. As a mediator associated with inflammation, A disintegrin and metalloprotease 10 (ADAM10) was hypothesized to play inhibitory roles in the development of TAO. Read More

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http://dx.doi.org/10.1016/j.bbrc.2018.09.002DOI Listing
October 2018
19 Reads

Cilostazol on the expression of ICAM-1, VCAM-1 and inflammatory factors in plasma in patients with thromboangiitis obliterans.

Exp Ther Med 2018 Sep 11;16(3):2349-2354. Epub 2018 Jul 11.

Department of Ophtalmology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong 250011, P.R. China.

The effects of cilostazol on the expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and inflammatory factors in plasma in patients with thromboangiitis obliterans (TAO) were studied. Plasma viscosity, fibrinogen, total cholesterol (TC) and triglyceride (TG) were detected for the healthy control, TAO and cilostazol groups, respectively. Results showed that compared with those in the control group, the plasma viscosity, fibrinogen, TC and TG levels in TAO group were significantly increased. Read More

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http://dx.doi.org/10.3892/etm.2018.6436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6122498PMC
September 2018
7 Reads

Purified CD34 cells versus peripheral blood mononuclear cells in the treatment of angiitis-induced no-option critical limb ischaemia: 12-Month results of a prospective randomised single-blinded non-inferiority trial.

EBioMedicine 2018 Sep 29;35:46-57. Epub 2018 Aug 29.

Department of Vascular Surgery, Zhongshan Hospital, and Institute of Vascular Surgery, Fudan University, Shanghai, China. Electronic address:

Background: Peripheral blood mononuclear cells (PBMNCs) and purified CD34 cells (PCCs) are increasingly being used at treating no-option critical limb ischaemia (NO-CLI). We aimed to compare the efficacies and uncover the advantages associated with each treatment approach.

Methods: A randomised single-blinded non-inferiority trial (Number: NCT 02089828) was performed. Read More

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http://dx.doi.org/10.1016/j.ebiom.2018.08.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156701PMC
September 2018
3 Reads

Levistilide A Ameliorates NLRP3 Expression Involving the Syk-p38/JNK Pathway and Peripheral Obliterans in Rats.

Mediators Inflamm 2018 12;2018:7304096. Epub 2018 Aug 12.

Institute of Interdisciplinary Medical Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Background: Inflammation is one of the most important pathogeneses of thromboangiitis obliterans (TAO). The NLRP3 inflammasome plays a vital role in the body's immune response and disease development. It can be activated by numerous types of pathogens or danger signals. Read More

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http://dx.doi.org/10.1155/2018/7304096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109531PMC
December 2018
8 Reads

Sequential intravenous allogeneic mesenchymal stromal cells as a potential treatment for thromboangiitis obliterans (Buerger's disease).

Stem Cell Res Ther 2018 05 30;9(1):150. Epub 2018 May 30.

Department of Hematology, Cell Therapy Unit, IBSAL-Hospital Universitario de Salamanca, Paseo de San Vicente 58-182, 37007, Salamanca, Spain.

Thromboangiitis obliterans (TAO), also known as Buerger's Disease, is an occlusive vasculitis linked with high morbidity and amputation risk. To date, TAO is deemed incurable due to the lack of a definitive treatment. The immune system and inflammation are proposed to play a central role in TAO pathogenesis. Read More

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http://dx.doi.org/10.1186/s13287-018-0901-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977545PMC
May 2018
31 Reads

Vascular Changes of Complex Regional Pain Syndrome Unmask Buerger's Disease (Thromboangiitis Obliterans): A Letter to the Editor.

Pain Med 2018 Sep;19(9):1880-1881

Departments of Rheumatology and Persistent Pain, Royal Hobart Hospital, Tasmania, Australia.

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http://dx.doi.org/10.1093/pm/pny098DOI Listing
September 2018
6 Reads

Treatment of multiple refractory ankle ulcerations in thromboangiitis obliterans: A case report.

Medicine (Baltimore) 2018 May;97(20):e10798

Division of Rheumatology, Immunology, and Allergy, Department of Internal Medicine, Tri-Service General Hospital.

Rationale: Thromboangiitis obliterans (TAOs, or Buerger's disease) present as a non-atherosclerotic segmental occlusive vasculitis within medium- and small-sized blood vessels. TAO frequently occurs in young adults and is associated with cigarette smoking. At present, there are no accurately defined treatments for TAO. Read More

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http://dx.doi.org/10.1097/MD.0000000000010798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976294PMC
May 2018
9 Reads

The Status of Nitric Oxide and its Backup, Heme Oxygenase 1, in Thromboangiitis Obliterans.

Rep Biochem Mol Biol 2018 Apr;6(2):197-202

Inflammation and Inflammatory Diseases Division of Immunology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Until recently, a gene polymorphism in the promoter region of endothelial nitric oxide synthase has been suggested as a risk factor for thromboangiitis obliterans (TAO) development. The aim of this study was to compare the metabolites of nitric oxide (NO) and its backup, heme-oxygenase-1 (HMOX1), between TAO patients and those of a smoking control group matched by race, age, sex, and smoking habits.

Methods: Twenty-four male Caucasian TAO patients and 20 male Caucasian controls enrolled in the study. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5941125PMC
April 2018
6 Reads

Anti-inflammatory activities and potential mechanisms of phenolic acids isolated from Salvia miltiorrhiza f. alba roots in THP-1 macrophages.

J Ethnopharmacol 2018 Aug 9;222:201-207. Epub 2018 May 9.

Department of Natural Products Chemistry, Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, PR China. Electronic address:

Ethnopharmacological Relevance: The roots of Salvia miltiorrhiza f. alba (Lamiaceae) (RSMA) are used as the Danshen, a traditional Chinese medicine, to treat the vascular diseases at local clinics, especially for the remedy of thromboangiitis obliterans (TAO) more than 100 years. Phenolic acids are one of the major effective constituents of RSMA, and some studies have linked phenolic acids with anti-inflammatory functions. Read More

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http://dx.doi.org/10.1016/j.jep.2018.05.008DOI Listing
August 2018
2 Reads

Lumbar sympathectomy versus prostanoids for critical limb ischaemia due to non-reconstructable peripheral arterial disease.

Cochrane Database Syst Rev 2018 04 16;4:CD009366. Epub 2018 Apr 16.

Vascular Surgery, Christian Medical College, Vellore, Tamil Nadu, India, 632004.

Background: Peripheral arterial disease (PAD) is a common circulatory problem that can lead to reduced blood flow to the limbs, which may result in critical limb ischaemia (CLI), a painful manifestation that occurs when a person is at rest. The mainstay of treatment for CLI is surgical or endovascular repair. However, when these means of treatment are not suitable, due to anatomical reasons or comorbidities, treatment for pain is limited. Read More

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http://dx.doi.org/10.1002/14651858.CD009366.pub2DOI Listing
April 2018
8 Reads

Could Buerger's disease cause nonarteritic anterior ischemic optic neuropathy?: a rare case report.

Neurol Sci 2018 Jul 5;39(7):1309-1312. Epub 2018 Apr 5.

Bozyaka Training and Research Hospital, Department of Ophthalmology, Saim Çıkrıkcı Cad. No:59, Bozyaka, İzmir, Turkey.

We present an interesting case with nonarteritic anterior ischemic optic neuropathy (NAION) accompanied by Buerger's disease. A 43-year-old man was referred to our neuro-ophthalmology clinic with a complaint of visual deterioration in the left eye that started 5 days ago. He suffered from Buerger's disease, and he had acute pain in the right lower limb below the knee. Read More

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http://dx.doi.org/10.1007/s10072-018-3325-2DOI Listing
July 2018
3 Reads

Treatment of Arsenite Intoxication-Induced Peripheral Vasculopathy with Mesenchymal Stem Cells.

Int J Mol Sci 2018 Mar 29;19(4). Epub 2018 Mar 29.

Institute of Clinical Medicine, National Yang-Ming University, Taipei 11221, Taiwan.

Arsenite (As), a notorious toxic metal, is ubiquitously distributed in the earth and poses a serious threat to human health. Histopathological lesions of As intoxication are known as thromboangiitis obliterans, which are resistant to current treatment and often lead to lower limb amputation. In this study, we attempt to find that treatment with mesenchymal stem cells (MSCs) may be effective for As-induced vasculopathy. Read More

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http://dx.doi.org/10.3390/ijms19041026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5979449PMC
March 2018
6 Reads

Hyperbaric oxygen treatment in thromboangiitis obliterans: a retrospective clinical audit.

Diving Hyperb Med 2018 Mar 31;48(1):31-35. Epub 2018 Mar 31.

Underwater and Hyperbaric Medicine Department, Health Sciences University, Kanuni Research and Training Hospital, Trabzon.

Introduction: Wounds refractory to standard treatment in patients with thromboangiitis obliterans (TAO, Buerger's disease) are associated with amputation, other morbidity and mortality. The purpose of this study was to investigate the effect of hyperbaric oxygen treatment (HBOT) in patients with TAO.

Materials And Methods: Ninety-seven patients with TAO with ischaemic wounds treated between January 2007 and July 2016 were included in this dual-centre, non-randomised, retrospective study. Read More

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http://dx.doi.org/10.28920/dhm48.1.31-35DOI Listing
March 2018
7 Reads

Effect of revascularization on IL-6 and TNF-α in patients with thromboangiitis obliterans.

Exp Ther Med 2018 Apr 20;15(4):3947-3951. Epub 2018 Feb 20.

Department of Vascular Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China.

The aim of the study was to investigate the effects of revascularization in treating patients with thromboangiitis obliterans (TAO), to analyze the prognosis of TAO. The treatment group comprised 32 patients with TAO of lower limbs who were selected between March 2012 and March 2017. Patients in the treatment group were treated with revascularization (vascular bypass surgery, catheter-directed thrombolysis and angioplasty, endovascular angioplasty + stening, thromboectomy and/or endarterectomy) + Western medicine. Read More

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http://dx.doi.org/10.3892/etm.2018.5877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5844100PMC
April 2018
38 Reads
0.940 Impact Factor

Unilateral localized conjunctival amyloidosis in a patient with a history of contralateral orbit/eyelid lymphoma.

Exp Mol Pathol 2018 04 15;104(2):151-154. Epub 2018 Mar 15.

Department of Pathology and Laboratory Medicine, Harbor-UCLA Medical Center, Torrance, CA 90502, USA. Electronic address:

Amyloidosis is a disorder characterized by the deposition of insoluble abnormal proteins in the extracellular space. It may occur as a localized lesion or as a systemic disease involving multiple organs and systems. Localized conjunctival amyloidosis is rare and is less frequently associated with systemic involvement. Read More

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http://dx.doi.org/10.1016/j.yexmp.2018.03.003DOI Listing
April 2018
31 Reads

Autologous bone marrow-derived mononuclear cell therapy in Chinese patients with critical limb ischemia due to thromboangiitis obliterans: 10-year results.

Stem Cell Res Ther 2018 02 22;9(1):43. Epub 2018 Feb 22.

Department of Vascular Surgery, Xuanwu Hospital Capital Medical University, Beijing, China.

Background: For patients with thromboangiitis obliterans (TAO), revascularization with bypass or angioplasty is frequently not feasible due to the poor outflow of the distal small vessels. We evaluated the long-term results of our experience treating patients with TAO with autologous bone marrow-derived mononuclear cells (ABMMNCs) to determine the safety and efficacy of ABMMNC therapy in patients with critical limb ischemia due to TAO.

Methods: This was a retrospective chart review from a single university hospital vascular surgery center between January 2005 and July 2006. Read More

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http://dx.doi.org/10.1186/s13287-018-0784-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824551PMC
February 2018
3 Reads

How to Treat a Patient with Thromboangiitis Obliterans: A Systematic Review.

Ann Vasc Surg 2018 May 5;49:219-228. Epub 2018 Feb 5.

Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

To date, there is still no treatment protocol for patients with thromboangiitis obliterans (TAO) who are also afflicted with critical limb ischemia (CLI). Smoking cessation on its own cannot be considered a treatment for the purposes of salvaging a limb of a TAO patient with CLI. The aim of this review was to evaluate different studies of various treatment protocols for avoiding amputation in TAO patients. Read More

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http://dx.doi.org/10.1016/j.avsg.2017.10.022DOI Listing
May 2018
9 Reads

Papillophlebitis in a young male patient with Buerger's disease.

Arch Soc Esp Oftalmol 2018 Jul;93(7):354-356

Servicio de Oftalmología, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, España.

Clinical Case: A 27-year-old male with sudden visual loss of OD. He had a past history of heavy smoking, as well as a chronic ischaemia of his left lower limb of one-year onset. This led to a diagnosis of Buerger's disease, which is an inflammatory thrombotic disorder that affects small and medium vessels. Read More

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http://dx.doi.org/10.1016/j.oftal.2017.12.009DOI Listing
July 2018
6 Reads

Long-Term Clinical Outcomes Survey of Bone Marrow-Derived Cell Therapy in Critical Limb Ischemia in Japan.

Circ J 2018 Mar 30;82(4):1168-1178. Epub 2018 Jan 30.

Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine.

Background: The Therapeutic Angiogenesis by Cell Transplantation (TACT) trial demonstrated the efficacy and safety of autologous bone marrow-derived mononuclear cells (BM-MNCs) in patients with critical limb ischemia (CLI). The present study aimed to assess the long-term clinical outcomes of therapeutic angiogenesis using autologous BM-MNC implantation under advanced medical treatment in Japan.Methods and Results:The study was retrospective, observational, and non-controlled. Read More

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http://dx.doi.org/10.1253/circj.CJ-17-0510DOI Listing
March 2018
3 Reads

The IL-6/STAT3 pathway regulates adhesion molecules and cytoskeleton of endothelial cells in thromboangiitis obliterans.

Cell Signal 2018 Apr 13;44:118-126. Epub 2018 Jan 13.

Key Laboratory of Hepatosplenic Surgery, Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150001, China. Electronic address:

Thromboangiitis obliterans (TAO) (also known as Buerger's disease) is an inflammatory vascular disease that predominantly affects small- and medium-sized blood vessels of extremities. Endothelial cells play critical roles in the initiation and progression of this disease, but the underlying mechanisms remain unclear. In the present study, we demonstrate that patients with TAO had significantly higher levels of interleukin-6 (IL-6), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in their plasmas, and the involved arterial tissues expressed higher levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3), ICAM-1 and VCAM-1. Read More

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http://dx.doi.org/10.1016/j.cellsig.2018.01.015DOI Listing
April 2018
16 Reads
1 Citation
4.320 Impact Factor

[Acute kidney injury in thromboangiitis obliterans disease].

Nephrol Ther 2018 May 29;14(3):167-171. Epub 2017 Dec 29.

Service de néphrologie, hôpitaux des Pays du Mont-Blanc, 380, rue de l'Hôpital, 74700 Sallanches, France; Service de néphrologie, centre hospitalier Alpes-Léman, 558, route de Findrol, 74130 Contamine-sur-Arve, France. Electronic address:

Buerger's disease or thombo-angiitis obliterans disease is a small vessel's vasculitis, frequently observed in young and smoker's males. Diagnosis is based on both clinical and radiological arguments. There is no specific treatment designed for this disease. Read More

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http://dx.doi.org/10.1016/j.nephro.2017.10.006DOI Listing
May 2018
6 Reads

Endovascular Treatment of Thromboangiitis Obliterans (Buerger's Disease).

Vasc Endovascular Surg 2018 Feb 13;52(2):124-130. Epub 2017 Dec 13.

1 Vascular and Endovascular Surgery Research Center, Alavi Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Purpose: When critical limb ischemia (CLI) occurs in patients with thromboangiitis obliterans (TAO) or Buerger's disease, smoking cessation alone may be insufficient to relieve rest pain and promote wound healing. Accordingly, adjunctive measures are warranted to restore adequate blood flow required for limb salvage. This study aimed to evaluate the feasibility and efficacy of percutaneous transluminal angioplasty (PTA) for the treatment of patients with TAO and CLI. Read More

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http://dx.doi.org/10.1177/1538574417744085DOI Listing
February 2018
8 Reads

[Thromboangiitis obliterans: notions for practice].

Rev Med Suisse 2017 Dec;13(586):2129-2133

Service d'angiologie, Département cœur-vaisseaux, CHUV, 1011 Lausanne.

Thromboangiitis obliterans is an occlusive vasculopathy affecting small- and medium-size arteries. It can result in severe ischemic status. Thrombophlebitis can be associated. Read More

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December 2017
7 Reads

Immediate and late outcomes of endovascular therapy for lower extremity arteries in Buerger disease.

J Vasc Surg 2018 06 20;67(6):1769-1777. Epub 2017 Nov 20.

Division of Cardiology and Cardiovascular Research Institute, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.

Objective: Buerger disease is a rare inflammatory vasculopathy presenting with severe claudication or critical limb ischemia. In this study, we sought to evaluate the feasibility and clinical outcomes of endovascular therapy for Buerger disease involving arteries in the lower extremities.

Methods: Between January 2006 and May 2016, there were 44 Buerger disease patients (43 men; mean age, 40. Read More

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http://dx.doi.org/10.1016/j.jvs.2017.09.020DOI Listing
June 2018
14 Reads

Unexpected Inflammation in the Sympathetic Ganglia in Thromboangiitis Obliterans.

Int J Angiol 2017 Dec 27;26(4):212-217. Epub 2017 Jul 27.

Department of Clinical Immunology, Inflammation and Inflammatory Diseases Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

The aim of this study was to inspect more closely the microscopic and molecular sympathetic ganglia histology in thromboangiitis obliterans (TAO). The paraffin block and frozen RNAlater-treated tissue of the lumbar sympathetic ganglia of 19 TAO Caucasian male patients were evaluated. The gene expression of cluster of differentiation 4 (CD4) and cluster of differentiation 8 (CD8) markers in the frozen RNAlater-treated sympathetic ganglia tissues were evaluated by real-time polymerase chain reaction. Read More

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http://dx.doi.org/10.1055/s-0037-1604410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685794PMC
December 2017
5 Reads

Multi-organ vaso-occlusive disease: Buerger's or Kohlmeier-Degos disease?

Pathology 2017 Dec 31;49(7):798-801. Epub 2017 Oct 31.

Department of Nephrology, Monash Health, Melbourne, Australia; Centre for Inflammatory Diseases, Department of Medicine, Monash University, Clayton, Vic, Australia.

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http://dx.doi.org/10.1016/j.pathol.2017.06.008DOI Listing
December 2017
7 Reads

Successful Percutaneous Transcatheter Angioplasty of Radial Artery in Thromboangiitis Obliterans (Buerger's Disease).

JACC Cardiovasc Interv 2017 Nov 13;10(22):e205-e206. Epub 2017 Sep 13.

Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. Electronic address:

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http://dx.doi.org/10.1016/j.jcin.2017.06.066DOI Listing
November 2017
40 Reads

Chronic Nonatherosclerotic Occlusive Popliteal Artery Disease.

Ann Vasc Surg 2018 Feb 6;47:128-133. Epub 2017 Sep 6.

Department of Surgery, University of Ulsan College of Medicine and Asan Medical Center, Seoul, Republic of Korea. Electronic address:

Background: The outcomes of revascularization of nonatherosclerotic occlusive popliteal artery disease are unknown. Therefore, the objective of this study was to analyze the outcomes of recanalization of nonatherosclerotic occlusive popliteal artery disease, the results of which would be useful in creating surgical strategies for such cases.

Methods: From January 2000 to December 2015, a total of 22 patients with nonatherosclerotic occlusive popliteal artery disease underwent open surgical repair. Read More

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http://dx.doi.org/10.1016/j.avsg.2017.07.037DOI Listing
February 2018
21 Reads

Chronic lower extremity wound infection due to Kerstersia gyiorum in a patient with Buerger's disease: a case report.

BMC Infect Dis 2017 09 6;17(1):608. Epub 2017 Sep 6.

Medical Microbiology Department, Ankara Numune Research and Training Hospital, Hacettepe Mahallesi Talatpasa Bulvari No: 44 Altindag, Ankara, Turkey.

Background: Kerstersia gyiorum is an extremely rare pathogen of human infection. It can cause chronic infection in patients with underlying conditions. It can easily be misdiagnosed if proper diagnostic methods are not used. Read More

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http://dx.doi.org/10.1186/s12879-017-2711-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5588736PMC
September 2017
27 Reads

Pathogenesis of thromboangiitis obliterans: Gene polymorphism and immunoregulation of human vascular endothelial cells.

Atherosclerosis 2017 10 18;265:258-265. Epub 2017 Aug 18.

State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China. Electronic address:

Thromboangiitis obliterans (TAO) is a nonatherosclerotic, segmental, inflammatory vasculitis, which commonly affects the small- and medium-sized arteries of the upper and lower extremities. Despite its discovery more than a century ago, little progress has been made in its treatment. Unless the pathogenesis is elucidated, therapeutic approaches will be limited. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00219150173123
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http://dx.doi.org/10.1016/j.atherosclerosis.2017.08.009DOI Listing
October 2017
10 Reads

Endothelial dysfunction in patients with Buerger disease.

Vasc Health Risk Manag 2017 23;13:317-323. Epub 2017 Aug 23.

Division of Vascular and Endovascular Surgery, Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan.

We evaluated the endothelial function of patients with Buerger disease using peripheral arterial tonometry test, and examined the factors that are significantly correlated with the endothelial dysfunction in these patients. We performed the peripheral arterial tonometry test in 22 patients with Buerger disease. We recorded the patients' characteristics, including ankle brachial pressure index and reactive hyperemia index, which reflect the endothelial dysfunction. Read More

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http://dx.doi.org/10.2147/VHRM.S139892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574590PMC
September 2017
41 Reads

Surgical sympathectomy for Buerger's disease.

JRSM Open 2017 Aug 1;8(8):2054270417717666. Epub 2017 Aug 1.

Department of Surgery, Federal University of São Paulo (UNIFESP), São Paulo 55 04038000, Brazil.

Buerger's disease is characterized by recurring progressive inflammation and occlusions in small and medium arteries and veins of the limbs. Its cause is unknown, but it is most common in young men with a history of tobacco use. It is responsible for ischemic ulcers and extreme pain in the hands and feet. Read More

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http://dx.doi.org/10.1177/2054270417717666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5542326PMC
August 2017
20 Reads

Porcine arteriogenesis based on vasa vasorum in a novel semi-acute occlusion model using high-resolution imaging.

Heart Vessels 2017 Nov 3;32(11):1400-1409. Epub 2017 Aug 3.

Department for Angiology, Center for Internal Medicine I, Medizinische Hochschule Brandenburg (MHB), Brandenburg Medical School, Hochstr. 29, 14770, Brandenburg, Germany.

Bridging collaterals (BC) develop in several chronic total artery occlusion diseases, and can prevent extensive myocardial necrosis. Yet, their origin, growth process, and histo-morphology are still unclear. Since vasa vasorum (VV) may take part in collateralization, we hypothesized that VV are the basis for BCs. Read More

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http://dx.doi.org/10.1007/s00380-017-1028-xDOI Listing
November 2017
43 Reads

Treatment of Thromboangiitis Obliterans Using Smoking Cessation and Far-infrared Therapy: A Case Study.

Ostomy Wound Manage 2017 Jul;63(7):20-23

Thromboangiitis obliterans (Buerger's disease) is a rare, nonatherosclerotic segmental inflammatory vasculitis that commonly involves small- and medium-sized vessels. Ischemic tenderness impairs patient quality of life and places patients at high risk for amputation. The only definitive known treatment is smoking cessation. Read More

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July 2017
4 Reads

Conservative treatment of patients with thromboangiitis obliterans or cannabis-associated arteritis presenting with critical lower limb ischaemia.

Vasa 2017 Oct 28;46(6):471-475. Epub 2017 Jul 28.

1 Department of Vascular Surgery, KAT General Hospital, Kifissia, Greece.

Background: Proper management of patients with thromboangiitis obliterans (TAO) or cannabis-associated arteritis (CAA), presenting with critical lower limb ischaemia (CLI) remains controversial, and data are limited.

Patients And Methods: Patients with TAO or CAA presenting with CLI between 2011 and 2016 were retrospectively evaluated. Patients requiring primary intervention were excluded. Read More

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http://dx.doi.org/10.1024/0301-1526/a000649DOI Listing
October 2017
59 Reads

Endovascular Therapy Outcomes and Intravascular Ultrasound Findings in Thromboangiitis Obliterans (Buerger's Disease).

J Endovasc Ther 2017 Aug;24(4):504-515

1 Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan.

Purpose: To investigate outcomes of contemporary endovascular therapy and intravascular ultrasound (IVUS) findings in thromboangiitis obliterans (TAO) patients.

Methods: Between April 2007 and January 2016, 20 patients (mean age 45±8 years; 16 men) underwent endovascular therapy for TAO-related lesions in 25 consecutive limbs. Subjects exhibited a broad array of clinical symptoms, including critical limb ischemia (n=15) and claudication (10) in the lower (n=20) and upper (n=5) limbs. Read More

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http://dx.doi.org/10.1177/1526602817710917DOI Listing
August 2017
20 Reads

Outcomes of endovascular recanalization versus autogenous venous bypass for thromboangiitis obliterans patients with critical limb ischemia due to tibioperoneal arterial occlusion.

J Vasc Surg 2017 10 8;66(4):1133-1142.e1. Epub 2017 Jul 8.

Department of Vascular Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, and Vascular Center of Shanghai Jiaotong University, Shanghai, China. Electronic address:

Objective: This study sought to compare the outcomes of endovascular recanalization (ER) vs autogenous venous bypass (AVB) for tibioperoneal arterial occlusion in thromboangiitis obliterans patients with critical lower limb ischemia.

Methods: A total of 90 limbs in 75 patients, successfully treated with ER (ER group, 35 patients, 43 limbs) and AVB (AVB group, 40 patients, 47 limbs) for tibioperoneal arterial occlusions from January 2009 to December 2015 in a single institution, were retrospectively analyzed. The characteristics and outcomes were compared between the two groups. Read More

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http://dx.doi.org/10.1016/j.jvs.2017.03.425DOI Listing
October 2017
13 Reads

Sympathetic Denervation Using Endovascular Radiofrequency Ablation in Patients with Thromboangiitis Obliterans (Buerger's Disease).

Ann Vasc Surg 2017 11 6;45:336. Epub 2017 Jul 6.

Vascular and Endovascular Surgery Research Center, Alavi Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.avsg.2017.06.132DOI Listing
November 2017
6 Reads

Retinal Artery Occlusion Secondary to Buerger's Disease (Thromboangiitis Obliterans).

Case Rep Ophthalmol Med 2017 16;2017:3637207. Epub 2017 Apr 16.

Beyoglu Eye Training and Research Hospital, Istanbul, Turkey.

To report a case report of one patient suffering from retinal artery occlusion secondary to Buerger's disease, in order to raise awareness to this etiology in the differential diagnosis of retinal artery occlusion. A retrospective case report of a patient with retinal artery occlusion secondary to Buerger's disease. Data retrieved from the medical records included exposure, complaints, visual acuity, clinical findings and imaging, laboratory assessment, treatment, disease course, and visual outcome. Read More

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http://dx.doi.org/10.1155/2017/3637207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5410370PMC
April 2017
13 Reads

Clinical features and predictors of patients with critical limb ischemia who responded to autologous mononuclear cell transplantation for therapeutic angiogenesis.

Heart Vessels 2017 Sep 29;32(9):1099-1108. Epub 2017 Mar 29.

Department of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.

The clinical features of patients with critical limb ischemia (CLI) who responded to angiogenesis using autologous peripheral blood mononuclear cell transplantation (PB-MNC) have not yet been fully characterized, and there are no useful predictors to judge the curative effect in the early period after PB-MNC. This study sought to clarify the clinical features and predictors in patients with CLI who were successfully treated using PB-MNC. 30 consecutive patients [arteriosclerosis obliterans: 24 patients, thromboangiitis obliterans: 6 patients] who were diagnosed with major amputation despite maximal medical therapy were enrolled in this study. Read More

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http://dx.doi.org/10.1007/s00380-017-0968-5DOI Listing
September 2017
8 Reads

Efficacy of Endovascular Radiofrequency Ablation for Thromboangiitis Obliterans (Buerger's Disease).

Ann Vasc Surg 2017 Jul 22;42:78-83. Epub 2017 Mar 22.

Department of Vascular Surgery, Shanghai First People's Hospital, Shanghai Jiao Tong University, Shanghai, China.

Background: This study aimed to evaluate the efficacy of endovascular radiofrequency ablation (RFA) for the treatment of thromboangiitis obliterans (TAO).

Methods: Total 30 males (median age: 46.00 years, interquartile range: 42. Read More

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http://dx.doi.org/10.1016/j.avsg.2016.11.012DOI Listing
July 2017
3 Reads