800 results match your criteria Buerger Disease Thromboangiitis Obliterans


Transatlantic combined and comparative data analysis of 1095 patients with urea cycle disorders-A successful strategy for clinical research of rare diseases.

J Inherit Metab Dis 2019 Jan;42(1):93-106

Centre for Pediatric and Adolescent Medicine, Division of Neuropediatrics and Inherited Metabolic Diseases, University Hospital Heidelberg, Im Neuenheimer Feld 430 69120, Heidelberg, Germany.

Background: To improve our understanding of urea cycle disorders (UCDs) prospectively followed by two North American (NA) and European (EU) patient cohorts.

Aims: Description of the NA and EU patient samples and investigation of the prospects of combined and comparative analyses for individuals with UCDs.

Methods: Retrieval and comparison of the data from 1095 individuals (NA: 620, EU: 475) from two electronic databases. Read More

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http://doi.wiley.com/10.1002/jimd.12031
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http://dx.doi.org/10.1002/jimd.12031DOI Listing
January 2019
6 Reads

Examining the responses of the zebrafish (Danio rerio) gastrointestinal system to the suspected obesogen diethylhexyl phthalate.

Environ Pollut 2019 Feb 16;245:1086-1094. Epub 2018 Nov 16.

Department of Environmental and Global Health, University of Florida, Gainesville, FL, 32611, USA; Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL, 32611, USA. Electronic address:

Epidemiological evidence suggests that phthalate plasticizers may act as "obesogens", which are chemicals that exacerbate obesity. The gastrointestinal (GI) system is the primary exposure route for phthalates, however, the relationship between phthalate-driven perturbations of GI system functions that can influence obesity has yet to be examined. To address this knowledge gap, we exposed Danio rerio (zebrafish) for 60 days to either (1) Control feeding (5 mg/fish/day), (2) Overfeeding (20 mg/fish/day) or (3) Overfeeding with diethyl-hexyl phthalate (DEHP) (20 mg/fish/day with 3 mg/kg DEHP). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S02697491183342
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http://dx.doi.org/10.1016/j.envpol.2018.11.032DOI Listing
February 2019
5 Reads
4.143 Impact Factor

Impairment of cognitive function in ornithine transcarbamylase deficiency is global rather than domain-specific and is associated with disease onset, sex, maximum ammonium, and number of hyperammonemic events.

J Inherit Metab Dis 2019 Mar 22;42(2):243-253. Epub 2019 Jan 22.

Division of Neuropaediatrics and Inherited Metabolic Diseases, Centre for Child and Adolescent Medicine, University Hospital Heidelberg, Heidelberg, Germany.

Beginning in 2006, the Urea Cycle Disorders Consortium (UCDC) has conducted a longitudinal study of eight inherited deficiencies of enzymes and transporters of the urea cycle, including 444 individuals with ornithine transcarbamylase deficiency (OTCD), of whom 300 (67 males, 233 females) received psychological evaluation. In a cross-sectional study (age range, 3-71 years), analysis of covariance (ANCOVA) determined the association between outcomes in five cognitive domains (global intelligence, executive functions, memory, visuomotor integration, visual perception) and sex, age at testing and timing of disease onset defined as early onset (≤28 days; EO), late onset (LO), or asymptomatic (AS). The dataset of 183 subjects with complete datasets (31 males, 152 females) revealed underrepresentation of EO subjects (2 males, 4 females), who were excluded from the ANCOVA. Read More

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http://dx.doi.org/10.1002/jimd.12013DOI Listing
March 2019
3 Reads

Prevalence of abnormal Alzheimer's disease biomarkers in patients with subjective cognitive decline: cross-sectional comparison of three European memory clinic samples.

Alzheimers Res Ther 2019 Jan 17;11(1). Epub 2019 Jan 17.

German Center for Neurodegenerative Diseases, Sigmund-Freud-Straße 27, 53127, Bonn, Germany.

Introduction: Subjective cognitive decline (SCD) in cognitively unimpaired older individuals has been recognized as an early clinical at-risk state for Alzheimer's disease (AD) dementia and as a target population for future dementia prevention trials. Currently, however, SCD is heterogeneously defined across studies, potentially leading to variations in the prevalence of AD pathology. Here, we compared the prevalence and identified common determinants of abnormal AD biomarkers in SCD across three European memory clinics participating in the European initiative on harmonization of SCD in preclinical AD (Euro-SCD). Read More

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http://dx.doi.org/10.1186/s13195-018-0463-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337830PMC
January 2019
10 Reads

Thromboangiitis Obliterans: 110 Years Old and Little Progress Made.

Authors:
Jeffrey W Olin

J Am Heart Assoc 2018 Dec;7(23):e011214

1 Zena and Michael A. Wiener Cardiovascular Institute & Marie-Jose'e and Henry R. Kravis Center for Cardiovascular Health Icahn School of Medicine at Mount Sinai New York NY.

See Article by Le Joncour et al . Read More

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http://dx.doi.org/10.1161/JAHA.118.011214DOI Listing
December 2018

Long-Term Outcome and Prognostic Factors of Complications in Thromboangiitis Obliterans (Buerger's Disease): A Multicenter Study of 224 Patients.

J Am Heart Assoc 2018 Dec;7(23):e010677

1 UPMC Univ Paris 06 UMR 7211, and Inflammation-Immunopathology-Biotherapy Department (DHU i2B) Sorbonne Universités Paris France.

Background Data regarding long-term outcome of patients with thromboangiitis obliterans are lacking and most series come from India and Japan. In this study, we assess long-term outcome and prognostic factors in a large cohort of thromboangiitis obliterans. Methods and Results Retrospective multicenter study of characteristics and outcomes of 224 thromboangiitis obliterans patients fulfilling Papa's criteria were analyzed. Read More

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http://dx.doi.org/10.1161/JAHA.118.010677DOI Listing
December 2018
16 Reads

CSF total tau levels are associated with hippocampal novelty irrespective of hippocampal volume.

Alzheimers Dement (Amst) 2018 2;10:782-790. Epub 2018 Nov 2.

German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

Introduction: We examined the association between cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease, neural novelty responses, and brain volume in predementia old age.

Methods: We conducted a cross-sectional analysis of the observational, multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) study. Seventy-six participants completed task functional magnetic resonance imaging and provided CSF (40 cognitively unimpaired, 21 experiencing subjective cognitive decline, and 15 with mild cognitive impairment). Read More

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http://dx.doi.org/10.1016/j.dadm.2018.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280588PMC
November 2018
2 Reads

Epidermal mTORC1 Signaling Contributes to the Pathogenesis of Psoriasis and Could Serve as a Therapeutic Target.

Authors:
Claudia Buerger

Front Immunol 2018 30;9:2786. Epub 2018 Nov 30.

Department of Dermatology, Venerology and Allergology, Clinic of the Goethe University, Frankfurt am Main, Germany.

Although modern biologics targeting different inflammatory mediators show promising therapeutic success, comprehensive knowledge about the molecular events in psoriatic keratinocytes that contribute to the pathogenesis and could serve as therapeutic targets is still scarce. However, recent efforts to understand the deregulated signal transduction pathways have led to the development of small molecule inhibitors e.g. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02786DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284005PMC
November 2018
1 Read

PD-1 and PD-L1 Expression in Male Breast Cancer in Comparison with Female Breast Cancer.

Target Oncol 2018 Dec;13(6):769-777

Department of Pathology, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands.

Background: Male breast cancer is rare, as it represents less than 1% of all breast cancer cases. In addition, male breast cancer appears to have a different biology than female breast cancer. Programmed death-1 (PD-1) and its ligand, programmed death-ligand 1 (PD-L1), seem to have prognostic and predictive values in a variety of cancers, including female breast cancer. Read More

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http://link.springer.com/10.1007/s11523-018-0610-1
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http://dx.doi.org/10.1007/s11523-018-0610-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297201PMC
December 2018
9 Reads

Correspondence Between Resting-State and Episodic Memory-Task Related Networks in Elderly Subjects.

Front Aging Neurosci 2018 8;10:362. Epub 2018 Nov 8.

Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig Maximilian University, Munich, Germany.

Resting-state fMRI studies demonstrated temporally synchronous fluctuations in brain activity among ensembles of brain regions, suggesting the existence of intrinsic functional networks. A spatial match between some of the resting-state networks and regional brain activation during cognitive tasks has been noted, suggesting that resting-state networks support particular cognitive abilities. However, the spatial match and predictive value of any resting-state network and regional brain activation during episodic memory is only poorly understood. Read More

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http://dx.doi.org/10.3389/fnagi.2018.00362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236026PMC
November 2018
1 Read

Tissue-Based Mapping of the Fathead Minnow () Transcriptome and Proteome.

Front Endocrinol (Lausanne) 2018 6;9:611. Epub 2018 Nov 6.

Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL, United States.

Omics approaches are broadly used to explore endocrine and toxicity-related pathways and functions. Nevertheless, there is still a significant gap in knowledge in terms of understanding the endocrine system and its numerous connections and intricate feedback loops, especially in non-model organisms. The fathead minnow () is a widely used small fish model for aquatic toxicology and regulatory testing, particularly in North America. Read More

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http://dx.doi.org/10.3389/fendo.2018.00611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232228PMC
November 2018
11 Reads

A Preclinical Model for Studying Herpes Simplex Virus Infection.

J Invest Dermatol 2019 Mar 8;139(3):673-682. Epub 2018 Nov 8.

Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases, Medical University of Vienna, Vienna, Austria. Electronic address:

Herpes simplex virus (HSV) infections can cause considerable morbidity. Currently, nucleoside analogues such as acyclovir are widely used for treatment. However, HSV infections resistant to these drugs are a clinical problem among immunocompromised patients. Read More

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http://dx.doi.org/10.1016/j.jid.2018.08.034DOI Listing
March 2019
21 Reads

Performance of noninvasive laser Doppler flowmetry and laser speckle contrast imaging methods in diagnosis of Buerger disease: A case report.

Medicine (Baltimore) 2018 Oct;97(43):e12979

Department of Vascular Medicine, Rennes University Hospital, Rennes.

Rationale: Buerger disease (BD) is a nonatherosclerotic, inflammatory, segmental vascular occlusive disease, which affects small and medium-sized arteries and veins and is triggered by substantial tobacco exposure. Angiographic findings consistent with BD are required for diagnosis. Laser Doppler flowmetry (LDF) and laser speckle contrast imaging (LSCI) could represent potential noninvasive alternative techniques to angiography. Read More

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http://dx.doi.org/10.1097/MD.0000000000012979DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221735PMC
October 2018
22 Reads

Automated assessment of paraspinal muscle fat composition based on the segmentation of chemical shift encoding-based water/fat-separated images.

Eur Radiol Exp 2018 Nov 7;2(1):32. Epub 2018 Nov 7.

Philips Research Laboratories, Hamburg, Germany.

Proton-density fat fraction (PDFF) of the paraspinal muscles, derived from chemical shift encoding-based water-fat magnetic resonance imaging, has emerged as an important surrogate biomarker in individuals with intervertebral disc disease, osteoporosis, sarcopenia and neuromuscular disorders. However, quantification of paraspinal muscle PDFF is currently limited in clinical routine due to the required time-consuming manual segmentation procedure. The present study aimed to develop an automatic segmentation algorithm of the lumbar paraspinal muscles based on water-fat sequences and compare the performance of this algorithm to ground truth data based on manual segmentation. Read More

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http://dx.doi.org/10.1186/s41747-018-0065-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219990PMC
November 2018
2 Reads

One-step laryngotracheal reconstruction with prefabricated cortico-periosteal flap.

Ann Thorac Surg 2018 Oct 31. Epub 2018 Oct 31.

Department of Otolaryngology and Head and Neck Surgery, University of Medical Sciences, Poznan, Poland.

Large airway reconstruction is difficult and requires a flap which will mirror the tissue variety. The main challenge is to keep the reconstruction stable and prevent collapse. In this report, the authors present a laryngotracheal reconstruction with a buccal mucosa-prefabricated medial femoral condyle free flap, after chondroma excision in a one-step procedure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00034975183154
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http://dx.doi.org/10.1016/j.athoracsur.2018.09.028DOI Listing
October 2018
15 Reads

Smaller medial temporal lobe volumes in individuals with subjective cognitive decline and biomarker evidence of Alzheimer's disease-Data from three memory clinic studies.

Alzheimers Dement 2019 Feb 12;15(2):185-193. Epub 2018 Oct 12.

Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany; German Center for Neurodegenerative Disorder (DZNE), Bonn, Germany.

Introduction: Previous studies showed associations of brain volume differences and biomarker evidence for Alzheimer's disease (AD) in subjective cognitive decline (SCD). The consistency of this finding across SCD studies has not been investigated.

Methods: We studied gray matter volume differences between SCD subjects with and without cerebrospinal fluid biomarker evidence for AD across three European memory clinic samples (German Center for Neurodegenerative Diseases Longitudinal Cognitive Impairment and Dementia study, Amsterdam, Barcelona). Read More

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http://dx.doi.org/10.1016/j.jalz.2018.09.002DOI Listing
February 2019
7 Reads

Novel T4 bacteriophages associated with black band disease in corals.

Environ Microbiol 2018 Oct 2. Epub 2018 Oct 2.

Australian Institute of Marine Science, Townsville, 4810, QLD, Australia.

Research into causative agents underlying coral disease have focused primarily on bacteria, whereas potential roles of viruses have been largely unaddressed. Bacteriophages may contribute to diseases through the lysogenic introduction of virulence genes into bacteria, or prevent diseases through lysis of bacterial pathogens. To identify candidate phages that may influence the pathogenicity of black band disease (BBD), communities of bacteria (16S rRNA) and T4-bacteriophages (gp23) were simultaneously profiled with amplicon sequencing among BBD-lesions and healthy-coral-tissue of Montipora hispida, as well as seawater (study site: the central Great Barrier Reef). Read More

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http://doi.wiley.com/10.1111/1462-2920.14432
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http://dx.doi.org/10.1111/1462-2920.14432DOI Listing
October 2018
2 Reads

Hypotonic stress response of human keratinocytes involves LRRC8A as component of volume-regulated anion channels.

Exp Dermatol 2018 Dec;27(12):1352-1360

BRAIN AG, Zwingenberg, Germany.

The barrier function of the human epidermis is constantly challenged by environmental osmotic fluctuations. Hypotonic stress triggers cell swelling, which is counteracted by a compensatory mechanism called regulatory volume decrease (RVD) involving volume-regulated anion channels (VRACs). Recently, it was discovered that VRACs are composed of LRRC8 heteromers and that LRRC8A functions as the essential VRAC subunit in various mammalian cell types; however, the molecular identity of VRACs in the human epidermis remains to be determined. Read More

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http://dx.doi.org/10.1111/exd.13789DOI Listing
December 2018
31 Reads

Three cases of dorsal metatarsal artery bypass in patients with Buerger disease.

J Vasc Surg Cases Innov Tech 2018 Sep 17;4(3):185-188. Epub 2018 Aug 17.

Division of Vascular Surgery, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Buerger disease is a rare peripheral vascular disease that most frequently affects young men and is strongly correlated with tobacco use. Although several options have been suggested, no consensus exists on the management of patients with Buerger disease except for smoking cessation. Revascularization is sometimes required to salvage ischemic limbs; however, it is often not feasible because of a lack of distal target vessels. Read More

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http://dx.doi.org/10.1016/j.jvscit.2018.03.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6105765PMC
September 2018
2 Reads

Synthetic osmotic dilators in the induction of labour-An international multicentre observational study.

Eur J Obstet Gynecol Reprod Biol 2018 Oct 3;229:70-75. Epub 2018 Aug 3.

Ex-Medicem International, Prague, Czech Republic. Electronic address:

Introduction: To evaluate the effects of synthetic osmotic dilators (Dilapan-S/ Dilasoft) in women who required induction of labour in a large prospective multicentre international observational study.

Materials And Methods: Primary outcomes were duration of Dilapan-S/Dilasoft insertion (hours), total induction - delivery interval (hours) and the rate of vaginal deliveries within 24 h (%). Secondary outcomes were the number of dilators inserted, Bishop score increase after extraction of Dilapan-S/Dilasoft, complications during induction (uterine contractions, uterine tachysystole and hyperstimulation, effect on the fetus) and post induction (infections and neonatal outcomes), agents / procedures used for subsequent induction of labour, immediate rate of spontaneous labours following cervical ripening period, rate of spontaneous vaginal deliveries, rate of instrumental vaginal deliveries and caesarean sections. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2018.08.004DOI Listing
October 2018
9 Reads

The gut microbiome and aquatic toxicology: An emerging concept for environmental health.

Environ Toxicol Chem 2018 11 5;37(11):2758-2775. Epub 2018 Oct 5.

Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA.

The microbiome plays an essential role in the health and onset of diseases in all animals, including humans. The microbiome has emerged as a central theme in environmental toxicology because microbes interact with the host immune system in addition to its role in chemical detoxification. Pathophysiological changes in the gastrointestinal tissue caused by ingested chemicals and metabolites generated from microbial biodegradation can lead to systemic adverse effects. Read More

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http://doi.wiley.com/10.1002/etc.4249
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http://dx.doi.org/10.1002/etc.4249DOI Listing
November 2018
9 Reads

Role of columnar cell lesions in breast carcinogenesis: analysis of chromosome 16 copy number changes by multiplex ligation-dependent probe amplification.

Mod Pathol 2018 Dec 5;31(12):1816-1833. Epub 2018 Jul 5.

Department of Pathology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands.

Columnar cell lesions have been proposed as precursor lesions of low-grade breast cancer. The molecular characteristic of low-grade breast neoplasia is whole-arm loss of chromosome 16q. Copy number changes of 6 genes on 16p and 20 genes on 16q were analysed by multiplex ligation-dependent probe amplification in 165 lesions of 103 patients. Read More

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http://dx.doi.org/10.1038/s41379-018-0099-2DOI Listing
December 2018
3 Reads

Multicenter Resting State Functional Connectivity in Prodromal and Dementia Stages of Alzheimer's Disease.

J Alzheimers Dis 2018 ;64(3):801-813

German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.

Background: Alterations of intrinsic networks from resting state fMRI (rs-fMRI) have been suggested as functional biomarkers of Alzheimer's disease (AD).

Objective: To determine the diagnostic accuracy of multicenter rs-fMRI for prodromal and preclinical stages of AD.

Methods: We determined rs-fMRI functional connectivity based on Pearson's correlation coefficients and amplitude of low-frequency fluctuation in people with subjective cognitive decline, people with mild cognitive impairment, and people with AD dementia compared with healthy controls. Read More

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http://dx.doi.org/10.3233/JAD-180106DOI Listing
January 2018
13 Reads

The Effects on Parapatric Divergence of Linkage between Preference and Trait Loci versus Pleiotropy.

Genes (Basel) 2018 Apr 17;9(4). Epub 2018 Apr 17.

Department of Mathematics, University of Vienna, Oskar-Morgenstern-Platz 1, 1090 Vienna, Austria.

Attempts to uncover the genetic basis of female mating preferences and male signals involved in reproductive isolation have discovered intriguing cases in which loci contributing to these traits co-localize in their chromosomal positions. Such discoveries raise the question of whether alleles at certain loci contribute pleiotropically to male and female components of premating reproductive isolation, versus whether these loci are merely tightly linked. Here we use population genetic models to assess the degree to which these alternatives affect both short term and equilibrium patterns of trait (signal) and preference divergence. Read More

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http://dx.doi.org/10.3390/genes9040217DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5924559PMC

Broadband multizone sound rendering by jointly optimizing the sound pressure and particle velocity.

J Acoust Soc Am 2018 Mar;143(3):1477

Chair of Multimedia Communications and Signal Processing, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, 91058, Germany.

In this paper, a recently proposed approach to multizone sound field synthesis, referred to as joint pressure and velocity matching (JPVM), is investigated analytically using a spherical harmonics representation of the sound field. The approach is motivated by the Kirchhoff-Helmholtz integral equation and aims at controlling the sound field inside the local listening zones by evoking the sound pressure and particle velocity on surrounding contours. Based on the findings of the modal analysis, an improved version of JPVM is proposed, which provides both better performance and lower complexity. Read More

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http://dx.doi.org/10.1121/1.5026508DOI Listing

Hyperbaric oxygen treatment in thromboangiitis obliterans: a retrospective clinical audit.

Diving Hyperb Med 2018 Mar 31;48(1):31-35. Epub 2018 Mar 31.

Underwater and Hyperbaric Medicine Department, Health Sciences University, Kanuni Research and Training Hospital, Trabzon.

Introduction: Wounds refractory to standard treatment in patients with thromboangiitis obliterans (TAO, Buerger's disease) are associated with amputation, other morbidity and mortality. The purpose of this study was to investigate the effect of hyperbaric oxygen treatment (HBOT) in patients with TAO.

Materials And Methods: Ninety-seven patients with TAO with ischaemic wounds treated between January 2007 and July 2016 were included in this dual-centre, non-randomised, retrospective study. Read More

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http://dx.doi.org/10.28920/dhm48.1.31-35DOI Listing
March 2018
9 Reads

Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease.

Brain 2018 Apr;141(4):1186-1200

Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Feodor-Lynen Straße 17, 81377 Munich, Germany.

Patients with Alzheimer's disease vary in their ability to sustain cognitive abilities in the presence of brain pathology. A major open question is which brain mechanisms may support higher reserve capacity, i.e. Read More

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http://dx.doi.org/10.1093/brain/awy008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5888938PMC
April 2018
52 Reads
2 Citations
9.200 Impact Factor

[Digital ischemia revealing multiple myeloma].

J Med Vasc 2018 Feb 29;43(1):61-64. Epub 2017 Dec 29.

Service de médecine interne, CHU Hassan II, Fès, Maroc.

Digital ulcers generally arise in a context of microangiopathy-related focal ischemia. In women, connective tissue diseases are the main etiology, while in men the cause is often diffuse arterial disease, e.g. Read More

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http://dx.doi.org/10.1016/j.jdmv.2017.11.003DOI Listing
February 2018
1 Read

Design and first baseline data of the DZNE multicenter observational study on predementia Alzheimer's disease (DELCODE).

Alzheimers Res Ther 2018 Feb 7;10(1):15. Epub 2018 Feb 7.

German Center for Neurodegenerative Diseases (DZNE), Leipziger Straße 44, 39120, Magdeburg, Germany.

Background: Deep phenotyping and longitudinal assessment of predementia at-risk states of Alzheimer's disease (AD) are required to define populations and outcomes for dementia prevention trials. Subjective cognitive decline (SCD) is a pre-mild cognitive impairment (pre-MCI) at-risk state of dementia, which emerges as a highly promising target for AD prevention.

Methods: The German Center for Neurodegenerative Diseases (DZNE) is conducting the multicenter DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE), which focuses on the characterization of SCD in patients recruited from memory clinics. Read More

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http://dx.doi.org/10.1186/s13195-017-0314-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5802096PMC
February 2018
65 Reads

Papillophlebitis in a young male patient with Buerger's disease.

Arch Soc Esp Oftalmol 2018 Jul;93(7):354-356

Servicio de Oftalmología, Hospital Universitario de Fuenlabrada, Fuenlabrada, Madrid, España.

Clinical Case: A 27-year-old male with sudden visual loss of OD. He had a past history of heavy smoking, as well as a chronic ischaemia of his left lower limb of one-year onset. This led to a diagnosis of Buerger's disease, which is an inflammatory thrombotic disorder that affects small and medium vessels. Read More

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http://dx.doi.org/10.1016/j.oftal.2017.12.009DOI Listing
July 2018
10 Reads

The Reticulum-Associated Protein RTN1A Specifically Identifies Human Dendritic Cells.

J Invest Dermatol 2018 Jun 31;138(6):1318-1327. Epub 2018 Jan 31.

Department of Dermatology, Research Division of Biology and Pathobiology of the Skin, Medical University of Vienna, Vienna, Austria. Electronic address:

RTN1 is an endoplasmic reticulum-associated protein that was initially identified in neuronal tissues. Here we show that the main isoform RTN1A is a marker for dendritic cells. In the skin, HLA-DRCD1aCD207CD11c Langerhans cells were the only cells in the epidermis, and HLA-DRCD11c dendritic cells were the main cells in the dermis, expressing this protein. Read More

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http://dx.doi.org/10.1016/j.jid.2018.01.002DOI Listing
June 2018
11 Reads

Point-of-Care Ultrasound: A Trend in Health Care.

Radiol Technol 2017 Nov;89(2):127-138

Purpose: To discuss the current and growing use of point-of-care (POC) ultrasound in the management and care of patients.

Methods: Several electronic research databases were searched to find articles that emphasized the use of POC ultrasound by health care providers who manage and treat critically ill or injured patients. Thirty-five relevant peer-reviewed journal articles were selected for this literature review. Read More

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November 2017
1 Read

[Acute kidney injury in thromboangiitis obliterans disease].

Nephrol Ther 2018 May 29;14(3):167-171. Epub 2017 Dec 29.

Service de néphrologie, hôpitaux des Pays du Mont-Blanc, 380, rue de l'Hôpital, 74700 Sallanches, France; Service de néphrologie, centre hospitalier Alpes-Léman, 558, route de Findrol, 74130 Contamine-sur-Arve, France. Electronic address:

Buerger's disease or thombo-angiitis obliterans disease is a small vessel's vasculitis, frequently observed in young and smoker's males. Diagnosis is based on both clinical and radiological arguments. There is no specific treatment designed for this disease. Read More

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http://dx.doi.org/10.1016/j.nephro.2017.10.006DOI Listing
May 2018
8 Reads

The spatial coherence of noise fields evoked by continuous source distributions.

J Acoust Soc Am 2017 Nov;142(5):3025

Chair of Multimedia Communications and Signal Processing, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Cauerstraße 7, 91058 Erlangen, Germany.

In this work, analytic expressions for the spatial coherence of noise fields are derived in the modal domain with the aim of providing a sparse representation. For this purpose, the sound field in a region of interest is expressed in terms of a given pressure distribution on a virtual surrounding cylindrical or spherical surface. According to the Huygens-Fresnel principle, the sound pressure on this surface is represented by a continuous distribution of elementary line or point sources, where orthogonal basis functions characterize the spatial properties. Read More

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http://dx.doi.org/10.1121/1.5009451DOI Listing
November 2017

Immediate and late outcomes of endovascular therapy for lower extremity arteries in Buerger disease.

J Vasc Surg 2018 06 20;67(6):1769-1777. Epub 2017 Nov 20.

Division of Cardiology and Cardiovascular Research Institute, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea.

Objective: Buerger disease is a rare inflammatory vasculopathy presenting with severe claudication or critical limb ischemia. In this study, we sought to evaluate the feasibility and clinical outcomes of endovascular therapy for Buerger disease involving arteries in the lower extremities.

Methods: Between January 2006 and May 2016, there were 44 Buerger disease patients (43 men; mean age, 40. Read More

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http://dx.doi.org/10.1016/j.jvs.2017.09.020DOI Listing
June 2018
16 Reads

Unexpected Inflammation in the Sympathetic Ganglia in Thromboangiitis Obliterans.

Int J Angiol 2017 Dec 27;26(4):212-217. Epub 2017 Jul 27.

Department of Clinical Immunology, Inflammation and Inflammatory Diseases Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

The aim of this study was to inspect more closely the microscopic and molecular sympathetic ganglia histology in thromboangiitis obliterans (TAO). The paraffin block and frozen RNAlater-treated tissue of the lumbar sympathetic ganglia of 19 TAO Caucasian male patients were evaluated. The gene expression of cluster of differentiation 4 (CD4) and cluster of differentiation 8 (CD8) markers in the frozen RNAlater-treated sympathetic ganglia tissues were evaluated by real-time polymerase chain reaction. Read More

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http://dx.doi.org/10.1055/s-0037-1604410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5685794PMC
December 2017
7 Reads

Four-extremity salvage with long vein grafts in buerger disease.

Arch Plast Surg 2018 Jan 27;45(1):93-95. Epub 2017 Oct 27.

Department of Plastic and Reconstructive Surgery, Hanyang University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.5999/aps.2017.01256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5784380PMC
January 2018
6 Reads

Linguistic camouflage in girls with autism spectrum disorder.

Mol Autism 2017 30;8:48. Epub 2017 Sep 30.

Center for Autism Research, Children's Hospital of Philadelphia, Roberts Center for Pediatric Research, 2716 South Street, Philadelphia, PA 19146 USA.

Background: Autism spectrum disorder (ASD) is diagnosed more frequently in boys than girls, even when girls are equally symptomatic. Cutting-edge behavioral imaging has detected "camouflaging" in girls with ASD, wherein social behaviors appear superficially typical, complicating diagnosis. The present study explores a new kind of camouflage based on language differences. Read More

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http://dx.doi.org/10.1186/s13229-017-0164-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622482PMC
May 2018
63 Reads

Additive value of amyloid-PET in routine cases of clinical dementia work-up after FDG-PET.

Eur J Nucl Med Mol Imaging 2017 Dec 20;44(13):2239-2248. Epub 2017 Sep 20.

Department of Nuclear Medicine, University Hospital, LMU Munich, Munich, Germany.

Purpose: In recent years, several [F]-labeled amyloid-PET tracers have been developed and have obtained clinical approval. Despite their widespread scientific use, studies in routine clinical settings are limited. We therefore investigated the impact of [F]-florbetaben (FBB)-PET on the diagnostic management of patients with suspected dementia that was still unclarified after [F]-fluordeoxyglucose (FDG)-PET. Read More

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http://dx.doi.org/10.1007/s00259-017-3832-zDOI Listing
December 2017
14 Reads
5.383 Impact Factor

A PCR-Based Assay Targeting the Major Capsid Protein Gene of a Dinorna-Like ssRNA Virus That Infects Coral Photosymbionts.

Front Microbiol 2017 1;8:1665. Epub 2017 Sep 1.

Australian Institute of Marine ScienceTownsville, QLD, Australia.

The coral- association is a critical component of coral reefs as it is the main primary producer and builds the reef's 3-dimensional structure. A breakdown of this endosymbiosis causes a loss of the dinoflagellate photosymbiont, , and/or its photosynthetic pigments from the coral tissues (i.e. Read More

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http://dx.doi.org/10.3389/fmicb.2017.01665DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5585145PMC
September 2017
8 Reads

Coral larvae for restoration and research: a large-scale method for rearing larvae, inducing settlement, and establishing symbiosis.

PeerJ 2017 6;5:e3732. Epub 2017 Sep 6.

AIMS@JCU, Townsville, Queensland, Australia.

Here we describe an efficient and effective technique for rearing sexually-derived coral propagules from spawning through larval settlement and symbiont uptake with minimal impact on natural coral populations. We sought to maximize larval survival while minimizing expense and daily husbandry maintenance by experimentally determining optimized conditions and protocols for gamete fertilization, larval cultivation, induction of larval settlement by crustose coralline algae, and inoculation of newly settled juveniles with their dinoflagellate symbiont . Larval rearing densities at or below 0. Read More

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http://dx.doi.org/10.7717/peerj.3732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591638PMC
September 2017
11 Reads

Pathogenesis of thromboangiitis obliterans: Gene polymorphism and immunoregulation of human vascular endothelial cells.

Atherosclerosis 2017 10 18;265:258-265. Epub 2017 Aug 18.

State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, China. Electronic address:

Thromboangiitis obliterans (TAO) is a nonatherosclerotic, segmental, inflammatory vasculitis, which commonly affects the small- and medium-sized arteries of the upper and lower extremities. Despite its discovery more than a century ago, little progress has been made in its treatment. Unless the pathogenesis is elucidated, therapeutic approaches will be limited. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00219150173123
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http://dx.doi.org/10.1016/j.atherosclerosis.2017.08.009DOI Listing
October 2017
12 Reads

Endothelial dysfunction in patients with Buerger disease.

Vasc Health Risk Manag 2017 23;13:317-323. Epub 2017 Aug 23.

Division of Vascular and Endovascular Surgery, Department of Surgery, Tokyo Medical and Dental University, Tokyo, Japan.

We evaluated the endothelial function of patients with Buerger disease using peripheral arterial tonometry test, and examined the factors that are significantly correlated with the endothelial dysfunction in these patients. We performed the peripheral arterial tonometry test in 22 patients with Buerger disease. We recorded the patients' characteristics, including ankle brachial pressure index and reactive hyperemia index, which reflect the endothelial dysfunction. Read More

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http://dx.doi.org/10.2147/VHRM.S139892DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5574590PMC
September 2017
45 Reads

Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease.

N Engl J Med 2017 09 28;377(13):1217-1227. Epub 2017 Aug 28.

Clinical Trial Service Unit and Medical Research Council Population Health Research Unit, University of Oxford, Oxford, United Kingdom

Background: Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes. Read More

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http://dx.doi.org/10.1056/NEJMoa1706444DOI Listing
September 2017
11 Reads

Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease.

N Engl J Med 2017 10 27;377(14):1319-1330. Epub 2017 Aug 27.

From the Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON (J.W.E., S.J.C., J.B., R.G.H., O.S., E.M.L., S.S.A., D.L., S.Y.), and Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, QC (G.R.D.) - both in Canada; Estudios Clínicos Latino América and Instituto Cardiovascular de Rosario, Rosario, Argentina (R.D.); Amphia Ziekenhuis and Werkgroep Cardiologische Centra Nederland (WCN), Utrecht, the Netherlands (M.A.); Cardiocenter, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University, Prague, Czech Republic (P.W.); Osaka International Cancer Institute, Osaka, Japan (M.H.); Instituto Dante Pazzanese de Cardiologia (A.A.), and Hospital do Coração (L.S.P.), São Paulo; University of Washington Medical Center (K.R.H.B.) and University of Washington (J.P.), Seattle; Brigham and Women's Hospital Heart and Vascular Center, Harvard Medical School, Boston (D.L.B.); FuWai Hospital, Beijing (J.Z., Y.L.); National Association of Hospital Cardiologists Research Center (ANMCO), Florence, Italy (A.P.M.); Research Institute, Fundación Oftalmológica de Santander (FOSCAL)-Bucaramanga, Bucaramanga, Colombia (P.L.-J.); National University of Ireland, Galway (M.O.); Thrombosis Research Institute and University College London, London (A.K.K.), Centre for Cardiovascular Science, University of Edinburgh, Edinburgh (K.A.A.F.), and University of Glasgow, Glasgow (T.J.G.) - all in the United Kingdom; Collegium Medicum Jagiellonian University, Krakow, Poland (T.J.G); Institute of Cardiology, Kiev, Ukraine (A.N.P.); University of Würzburg and University Hospital, Würzburg (G.E., S.S.), and Bayer, Leverkusen (N.C.B., F.M., E.C.) - all in Germany; Semmelweis University, Budapest, Hungary (M.K.); Karolinska Institutet, Stockholm (L.R.); National Research Center for Preventative Medicine, Moscow (N.P.); University of Philippines, Manila (A.L.D.); Universidad de La Frontera, Temuco, Chile (F.L.); University of Cape Town, Cape Town, South Africa (P.J.C.); University of Aalborg, Copenhagen (C.T.-P.); University of Leuven, Leuven, Belgium (P.B.V.); University of Medicine and Pharmacology, Carol Davila University and Emergency Hospital, Bucharest, Romania (D.V.); Catholic University of Korea, Seoul, South Korea (J.-H.K.); Monash University, Melbourne, VIC, Australia (A.M.T.); Lady Davis Carmel Medical Center, Haifa, Israel (B.S.L.); Facultad de Ciencias de la Salud Eugenio Espejo-Universidad Tecnológica Equinoccial, Quito, Ecuador (C.F.); Universiti Teknologi Mara, Selangor, Malaysia (K.Y.); Université Paris Diderot, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Paris (P.G.S.); and Turku University Central Hospital and Turku University, Turku, Finland (K.P.M.).

Background: We evaluated whether rivaroxaban alone or in combination with aspirin would be more effective than aspirin alone for secondary cardiovascular prevention.

Methods: In this double-blind trial, we randomly assigned 27,395 participants with stable atherosclerotic vascular disease to receive rivaroxaban (2.5 mg twice daily) plus aspirin (100 mg once daily), rivaroxaban (5 mg twice daily), or aspirin (100 mg once daily). Read More

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http://dx.doi.org/10.1056/NEJMoa1709118DOI Listing
October 2017
46 Reads

Tau plasma levels in subjective cognitive decline: Results from the DELCODE study.

Sci Rep 2017 08 25;7(1):9529. Epub 2017 Aug 25.

Section for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.

Previous studies have demonstrated increased tau plasma levels in patients with Alzheimer's disease (AD) and mild cognitive impairment (MCI) due to AD. Much less is known whether increased tau plasma levels can already be detected in the pre-MCI stage of subjective cognitive decline (SCD). In the present study we measured tau plasma levels in 111 SCD patients and 134 age- and gender-matched cognitively healthy controls participating in the DZNE (German Center for Neurodegenerative Diseases) longitudinal study on cognition and dementia (DELCODE). Read More

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http://dx.doi.org/10.1038/s41598-017-08779-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5573353PMC
August 2017
43 Reads

Digital ischemia and tobacco.

Pan Afr Med J 2017;27:104. Epub 2017 Jun 12.

Autoinmune Disease Service, San Cecilio University Hospital, Granada, Spain.

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http://dx.doi.org/10.11604/pamj.2017.27.104.12932DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554632PMC
June 2017
2 Reads

Two-locus clines on the real line with a step environment.

Authors:
Reinhard Bürger

Theor Popul Biol 2017 10 14;117:1-22. Epub 2017 Aug 14.

Department of Mathematics, University of Vienna, Austria. Electronic address:

The shape of allele-frequency clines maintained by migration-selection balance depends not only on the properties of migration and selection, but also on the dominance relations among alleles and on linkage to other loci under selection. We investigate a two-locus model in which two diallelic, recombining loci are subject to selection caused by an abrupt environmental change. The habitat is one-dimensional and unbounded, selection at each locus is modeled by step functions such that in one region one allele at each locus is advantageous and in the other deleterious. Read More

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http://dx.doi.org/10.1016/j.tpb.2017.08.002DOI Listing
October 2017
22 Reads