3,341 results match your criteria Buerger Disease Thromboangiitis Obliterans

Thromboangiitis obliterans plasma-derived exosomal miR-223-5p inhibits cell viability and promotes cell apoptosis of human vascular smooth muscle cells by targeting VCAM1.

Ann Med 2021 12;53(1):1129-1141

Department of Vascular Surgery, Shanghai Pudong Hospital Affiliated to Fudan University, Shanghai, China.

Exosomes-encapsulated microRNAs (miRNAs) have been established to be implicated in the pathogenesis of different diseases. Nevertheless, circulating exosomal miRNAs of thromboangiitis obliterans (TAO) remains poorly understood. This study aimed to explore the effects of exosomal miRNAs associated with TAO on human vascular smooth muscle cells (HVSMCs). Read More

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December 2021

Milestones in thromboangiitis obliterans. A position paper of the VAS-European Independent Foundation in Angiology/Vascular Medicine.

Int Angiol 2021 Jul 8. Epub 2021 Jul 8.

Portiuncula University Hospital, Soalta University Health Care Group, National University of Ireland Galway (NUIG), Galway, Ireland.

Background: Unfortunately, even today Thromboangiitis Obliterans has disease features that remain misunderstood or underappreciated. The epidemiology, etiology and pathophysiology of the disease are still unclear. Biomarkers and disease activity markers are lacking, thus clinical assessment is difficult. Read More

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A Review of COVID-19 Chilblains-like Lesions and Their Differential Diagnoses.

Adv Skin Wound Care 2021 Jul;34(7):348-354

General Purpose: To familiarize wound care practitioners with the differential diagnoses of chilblains-like lesions that could be associated with the complications of COVID-19.

Target Audience: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

Learning Objectives/outcomes: After participating in this educational activity, the participant will:1. Read More

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Digital ischaemia aetiologies and mid-term follow-up: A cohort study of 323 patients.

Medicine (Baltimore) 2021 May;100(20):e25659

Department of Internal Medicine.

Abstract: Upper extremity digital ischaemia (UEDI) is a rare heterogeneous condition whose frequency is 40 times less than that of toe ischaemia. Using a large cohort, the aim of this study was to evaluate aetiologies, prognosis and midterm clinical outcomes of UEDI.All patients with UEDI with or without cutaneous necrosis in a university hospital setting between January 2000 to December 2016 were included. Read More

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Primary Refractory Catastrophic Antiphospholipid Syndrome Masquerading as Buerger's Disease.

Cureus 2021 Apr 7;13(4):e14350. Epub 2021 Apr 7.

Division of Hematology and Oncology, University of California - Irvine, Irvine, USA.

Catastrophic antiphospholipid syndrome (CAPS) is a lethal disease with up to 30% mortality rate. It can occur as a primary disease or secondary to an underlying autoimmune disease. Current treatment focuses on disease control with anticoagulation and steroids. Read More

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Para-Clinical and Immunological Evaluation in Buerger's Disease as a Suspected Autoimmune Disease: Case Series.

Rep Biochem Mol Biol 2021 Jan;9(4):379-384

Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Autoimmunity causes the loss of normal immune homeostasis and involves the presence of autoantibodies and inflammation. Thromboangiitis obliterans or Buerger's disease (BD) refers to a type of vascular obstructive syndrome, with tobacco exposure accounting for disease formation and progression. However, the current understanding of autoimmunity is unclear in the context of BD, and the scientific findings are not enough to support autoimmune mechanisms. Read More

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January 2021

Effect of Si-Miao-Yong-An decoction on the differentiation of monocytes, macrophages, and regulatory T cells in ApoE mice.

J Ethnopharmacol 2021 Aug 2;276:114178. Epub 2021 May 2.

Department of Cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. Electronic address:

Ethnopharmacological Relevance: Si-Miao-Yong-An decoction (SMYAD) is a renowned traditional Chinese medicinal formula. SMYAD was originally recorded in the "Shi Shi Mi Lu", which was edited by medical scientist Chen Shi'duo during the Qing Dynasty. SMYAD has been traditionally used to treat thromboangiitis obliterans. Read More

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Intestinal thromboangiitis obliterans: a case report.

J Med Case Rep 2021 Apr 23;15(1):215. Epub 2021 Apr 23.

Department of Surgery, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Background: Thromboangiitis obliterans or Buerger's disease is a form of peripheral vascular disease in young male smokers. The involvement of the intestine occurs in only about 2% of the cases, when they may present as acute abdomen due to mesenteric ischemia. The uncommonness of the condition makes it a less suspected differential diagnosis, leading to a delay in appropriate management, thereby increasing chances of morbidity or mortality. Read More

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Anti-thrombotic activity of phenolic acids obtained from Salvia miltiorrhiza f. alba in TNF-α-stimulated endothelial cells via the NF-κB/JNK/p38 MAPK signaling pathway.

Arch Pharm Res 2021 Apr 13;44(4):427-438. Epub 2021 Apr 13.

Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan, 250012, People's Republic of China.

Over the past 100 years, Salvia miltiorrhiza f. alba (Lamiaceae) (RSMA) roots have been used to cure thromboangiitis obliterans (TAO) in local clinics. This study aimed to confirm the anti-thrombotic efficacy of 12 phenolic acids obtained from RSMA and to clarify the possible underlying mechanisms. Read More

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A Review of COVID-19 Chilblains-like Lesions and their Differential Diagnosis.

Adv Skin Wound Care 2021 Mar 12. Epub 2021 Mar 12.

Medical Student, Faculty of Medicine, University of Toronto, Ontario, Canada Dermatology Resident, Department of Dermatology, University of Toronto, Ontario, Canada Medical Student, Faculty of Medicine, University of Toronto, Ontario, Canada Pediatric Dermatologist, Section of Dermatology, Division of Pediatric Medicine, The Hospital for Sick Children, University of Toronto, Ontario, Canada Editor-in-Chief Emeritus, Advances in Skin & Wound Care; the William Erdman Professor, Department of Physical Medicine and Rehabilitation; Senior Fellow, Institute on Aging; and Associate, Institute of Medicine and Bioengineering, University of Pennsylvania Health System, Philadelphia, Pennsylvania Staff Physician, Section of Dermatology, Division of Pediatric Medicine, The Hospital for Sick Children, University of Toronto, Ontario, Canada.

General Purpose: Forthcoming.

Target Audience: This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and nurses with an interest in skin and wound care.

Learning Objectives/outcomes: Forthcoming. Read More

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Effect of cannabis consumption on characteristics and evolution of thromboangitis obliterans.

Vasa 2021 Jul 19;50(4):301-305. Epub 2021 Mar 19.

Department of internal and vascular medicine, CHU de Nantes, France.

Thromboangiitis obliterans (TAO) is a distal non atherosclerotic thrombotic vasculitis affecting tobacco smokers. The role of cannabis co-exposure remains controversial. The study aims to assess how cannabis consumption influences clinical presentation and outcome of TAO in tobacco smokers. Read More

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Therapeutic Angiogenesis Using Bone Marrow-Derived Mononuclear Cell Implantation for Patients With Critical Limb-Threatening Ischemia Caused by Thromboangiitis Obliterans - Study Protocol for a Multicenter Prospective Interventional Trial.

Circ Rep 2020 Sep 15;2(10):630-634. Epub 2020 Sep 15.

Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine Kyoto Japan.

Patients with thromboangiitis obliterans (TAO) can develop critical limb-threatening ischemia (CLTI) and require limb amputation. Smoking cessation and exercise therapy are recommended as standard treatments, and revascularization by bypass surgery or endovascular therapy (EVT) is required for patients with CLTI. However, there are many cases in which revascularization is difficult because of vascular characteristics, and the patency rate after revascularization remains unsatisfactory. Read More

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September 2020

Cerebral venous and sinus thrombosis with complicating thromboangiitis obliterans.

CMAJ 2021 Mar;193(9):E311

Department of Neurology (Einsiedler, Topakian), and Institute of Radiology (Hödl), Academic Teaching Hospital Wels-Grieskirchen, Wels, Austria

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Thromboangiitis Obliterans.

Ju Yi Chen

Anatol J Cardiol 2021 02;25(2):E8

Department Of Internal Medicine, National Cheng Kung University Hospital, College Of Medicine, National Cheng Kung University, Tainan, Taiwan.

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February 2021

CT angiography and MRI of hand vascular lesions: technical considerations and spectrum of imaging findings.

Insights Imaging 2021 Feb 12;12(1):16. Epub 2021 Feb 12.

Service D'imagerie Guilloz, CHRU Nancy, 54 000, Nancy, France.

Vascular lesions of the hand are common and are distinct from vascular lesions elsewhere because of the terminal vascular network in this region, the frequent hand exposure to trauma and microtrauma, and the superficial location of the lesions. Vascular lesions in the hand may be secondary to local pathology, a proximal source of emboli, or systemic diseases with vascular compromise. In most cases, ischaemic conditions are investigated with Doppler ultrasonography. Read More

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February 2021

miR-100 alleviates the inflammatory damage and apoptosis of HO-induced human umbilical vein endothelial cells via inactivation of Notch signaling by targeting MMP9.

Vascular 2021 Feb 2:1708538121989854. Epub 2021 Feb 2.

Department of Peripheral Vascular Intervention, Gansu Provincial Hospital of TCM, Lanzhou, China.

Objective: Thromboangiitis obliterans is a nonatherosclerotic segmental inflammatory disease, and miR-100 plays an anti-inflammatory role in chronic inflammation. Therefore, we hypothesized that miR-100 might alleviate the inflammatory damage and apoptosis of HO-induced ECV304 cells and aimed to investigate the relationship between miR-100 and thromboangiitis obliterans and the related molecular mechanism.

Methods: Cell counting kit-8 was used to detect cell viability, and the expression of inflammatory factors and oxidative stress was measured by ELISA. Read More

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February 2021

Outcomes of Anticoagulant Therapy with Low-Molecular-Weight Heparin (LMWH) and Warfarin for Thromboangiitis Obliterans (TAO).

Curr Vasc Pharmacol 2021 01 18. Epub 2021 Jan 18.

Department of Vascular Surgery, Shijingshan Hospital, Beijing. China.

Background: Thromboangiitis obliterans (TAO) is a chronic, non-atherosclerotic, progressive inflammatory vascular disease affecting the small- and medium-size arteries and veins of the extremities.

Objective: To evaluate whether long-term anticoagulation with low-molecular-weight heparin (LMWH) and warfarin is beneficial for treating the inflammation and symptoms associated with TAO.

Methods: Patients with TAO who underwent anticoagulation as the mainstay of treatment were included in this prospective study. Read More

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January 2021

Variations in the origin, course and branching pattern of dorsalis pedis artery with clinical significance.

Sci Rep 2021 01 14;11(1):1448. Epub 2021 Jan 14.

Department of Anatomy, JSS Medical College, JSS AHER, 570015, Mysuru, India.

Pulsations of the dorsalis pedis artery are commonly used to evaluate the peripheral arterial diseases like thromboangiitis obliterans (TAO) or Buerger's disease, in lower limbs. Dorsalis pedis artery is a direct extension from the anterior tibial artery and major vascular supply for the dorsum of the foot. But arterial variations in lower limbs are common due to rich distal anastomoses around the ankle joint. Read More

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January 2021

Women and Pregnancy in Thromboangiitis Obliterans.

J Vasc Res 2021 12;58(2):131-133. Epub 2021 Jan 12.

Department of Internal Medicine and Clinical Immunology, Centre National de Référence des Maladies Autoimmunes Systémiques Rares, Centre National de Référence des Maladies Autoinflammatoires et de l'Amylose, Hôpital Pitié-Salpêtrière, APHP, Sorbonne Universités, INSERM, UMR_S 959, Paris, France.

Data regarding women and thromboangiitis obliterans (TAO) are conflicted, and a few cases of pregnancy have been described. We aimed to describe the interplay between TAO and pregnancies. Among 224 TAO patients, 22. Read More

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January 2021

Left Carotid Artery Thrombosis Due to Thromboangiitis Obliterans.

Am J Forensic Med Pathol 2020 Dec 16;Publish Ahead of Print. Epub 2020 Dec 16.

From the Department of Pathology, Emory University, Atlanta, GA Department of Pathology, Western Michigan University Homer Stryker MD School of Medicine, Kalamazoo, MI.

Abstract: Thromboangiitis obliterans (TAO, Buerger disease) is a segmental, non-atherosclerotic vasculitis that causes occlusion of the small and medium sized vessels of the distal extremities. In rare cases, it can affect vessels in the gastrointestinal, cerebrovascular, coronary, and renal systems. The etiology of thromboangiitis obliterans is unknown, but there is a strong association with smoking in the development and the progression of the disease. Read More

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December 2020

Thromboangiitis Obliterans Biomarker Shifts in Different Acute Phase Stages: A Case Study.

Ann Vasc Surg 2021 May 21;73:509.e5-509.e9. Epub 2021 Jan 21.

Division of Angiology, Department of Medicine 2, Medical University of Vienna, Vienna, Austria.

Thromboangiitis obliterans (TAO) is a rare vasculopathy that is predominantly seen in young male smokers. Recently, new biomarkers have been shown to be useful in distinguishing TAO from acute phase TAO in an Asian study population. The present case study illustrates their application in a European patient during TAO exacerbation and their association with therapeutic performance. Read More

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Endovascular Treatment of Critical Limb Ischemia in Buerger Disease (Thromboangiitis Obliterans) With Midterm Follow-Up: A Viable Option When Bypass Surgery Is Not Feasible.

AJR Am J Roentgenol 2021 02 16;216(2):421-427. Epub 2020 Dec 16.

Department of Radiology, Okan University Hospital, Aydınlı Cad No 2, Okan Universitesi Hastanesi İçmeler, Tuzla, Istanbul, Turkey 34947.

Thromboangiitis obliterans (TAO) is an occlusive inflammatory disease affecting small- and medium-sized vessels that causes decrease in life quality and eventually limb loss. The only proven treatment method is smoking cessation, but it may be insufficient for limb salvage in patients with critical limb ischemia. In this single-center retrospective study, the feasibility and efficiency of endovascular treatment in TAO were evaluated. Read More

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February 2021

The incidence, prevalence, and survival rate of thromboangiitis obliterans in Korea: a retrospective population-based study.

Cardiovasc Diagn Ther 2020 Oct;10(5):1238-1244

Department of Rehabilitation Medicine, Konkuk University Chungju Hospital, Konkuk University School of Medicine, 82 Gugwon-daero, Chungju, Republic of Korea.

Background: Few studies used nationwide data to assess the age-standardized prevalence rate, incidence rate, 10-year survival rate, and death risk of thromboangiitis obliterans (TAO; Buerger's disease).

Methods: Data for 24,392 patients who had newly diagnoses related to TAO (I73.1) from 2006 through 2017 were extracted from the National Health Insurance Service in Korea. Read More

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October 2020

Cytokine analysis in patients with different stages of thromboangiitis obliterans.

Curr Mol Med 2020 Nov 19. Epub 2020 Nov 19.

Immunology Research Center, Mashhad University of Medical Sciences, Mashhad. Iran.

Background: Studies suggest that cytokines are involved in the development of both inflammatory disorders and vascular diseases.

Objective: The changes in transforming growth factor β (TGFβ), interleukin 6 (IL6), tumor necrosis factor α (TNFα), and interferon γ (IFNγ) with the progression of the thromboangiitis obliterans (TAO) symptomswereinvestigated in this research.

Methods: This study included 80 patients with TAO, who were selected from the Vascular and Endovascular Research Center in Alavi Hospital between 2012 and 2016. Read More

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November 2020

Patterns of arterial involvement and feasibility of revascularization in thromboangiitis obliterans: a tertiary care centre experience.

ANZ J Surg 2020 12 11;90(12):2506-2509. Epub 2020 Nov 11.

Department of Vascular Surgery, Christian Medical College Hospital, Vellore, India.

Background: Arterial revascularization is seldom considered as a treatment option in thromboangiitis obliterans (TAO) due to diffuse segmental involvement of medium- and small-sized extremity vessels. Although typical angiographic features include bilaterally symmetrical involvement of infrapopliteal vessels, larger vessels too can be affected. Similarly, there could be distal target vessels feasible for revascularization. Read More

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December 2020

MiR-223 alleviates thrombus and inflammation in thromboangiitis obliterans rats by regulating NLRP3.

Eur Rev Med Pharmacol Sci 2020 10;24(20):10605-10611

Department of Vascular Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.

Objective: The aim of this study was to observe the regulatory effects of micro ribonucleic acid (miR)-223 on thromboangiitis obliterans (TAO) rats, and to explore the potential regulatory mechanism.

Materials And Methods: Online database TargetScan was used to predict the downstream regulatory targets of miR-223. A total of 45 Sprague Dawley (SD) rats were randomly divided into three groups, including sham operation group (Sham group), Model group, and miR-223 agonist group (miR-223 mimic group). Read More

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October 2020

Predictive value of serum VEGF, IL-1 and TNF-α in the treatment of thromboangiitis obliterans by revascularization.

Exp Ther Med 2020 Dec 16;20(6):232. Epub 2020 Oct 16.

The Department of Interventional Radiology of The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.

Effect of revascularization in the treatment of thromboangiitis obliterans (TAO) and the predictive value of serum vascular endothelial growth factor (VEGF), interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) of risk factors of amputation were investigated. From April 2012 to August 2015, a total of 117 patients with TAO admitted to the First Hospital of Lanzhou University were selected. Patients treated with revascularization combined with prostaglandin sodium and cilostazol were enrolled in group A (67 patients), and patients treated with sodium and cilostazol were enrolled in group B (50 patients). Read More

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December 2020

Autologous peripheral blood-derived stem cells transplantation for treatment of no-option angiitis-induced critical limb ischemia: 10-year management experience.

Stem Cell Res Ther 2020 10 28;11(1):458. Epub 2020 Oct 28.

Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: Previous studies have demonstrated that no-option angiitis-induced critical limb ischemia (NO-AICLI) could be significantly improved by transplantation of peripheral blood-derived stem cells (PBDSCs). Additionally, a randomized controlled trial (RCT) recently conducted by us suggested that peripheral blood-derived purified CD34+ cells (PCCs) were not inferior to non-purified peripheral blood mononuclear cells (PBMNCs) at limb salvage in treatment of NO-AICLI. However, most of these clinical trials whether RCT or single-arm studies were characterized with a small sample size and absence of long-term outcomes. Read More

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October 2020

A curious case of finger pain.

Med J Aust 2020 11 22;213(10):452-452.e1. Epub 2020 Oct 22.

Alfred Hospital, Melbourne, VIC.

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November 2020

Structural Determination of a New Cycloartane Glycoside from Asplenium ruprechtii.

Chem Biodivers 2020 Dec 9;17(12):e2000500. Epub 2020 Nov 9.

College of Pharmacy, Ningxia Medical University, Yinchuan, 750004, P. R. China.

We characterized a new cycloartane glycoside, herein known as aspleniumside F (1), along with five known compounds as kaempferol-3-O-[(6-O-(E)-feruloyl)-β-D-glucopyranosyl]-(1→2)-β-D-galacopyranoside (2), quercetin-3-O-[(6-O-(E)-feruloyl)-β-D-glucopyranosyl]-(1→2)-β-D-glucopyranoside (3), kaempferol-3-O-[(6-O-(E)-caffeoyl)-β-D-glucopyranosyl]-(1→2)-β-D-glucopyranoside (4), kaempferol-3-O-[(6-O-(E)-caffeoyl)-β-D-glucopyranosyl]-(1→2)-β-D-glucopyranosyl-7-O-β-D-glucopyranoside (5), and kaempferol-3-O-[(6-O-p-coumaroyl)-β-D-glucopyranosyl]-(1→2)-β-D-glucopyranosyl-7-O-β-D-glucopyranoside (6), from Asplenium ruprechtii Sa. Kurata, a folk medicine widely used to treat Thromboangiitis obliterans in China, Japan, and Korea. Based on spectroscopic, mainly 1D-, 2D-NMR and (+)-HR-ESI-MS, analyses as well as through comparisons with previous reports, its chemical structure was determined as 3β,24,30-tri-β-D-glucopyranosyl-23,25-dihydroxycycloartane (= (23R,24R)-3β,24-bis-(β-D-glucopyranosyloxy)-23,25-dihydroxy-9β-9,19-cyclolanostan-29-yl β-D-glucopyranoside). Read More

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December 2020