Search Our Scientific Publications & Authors

Head Neck Pathol 2021 May 12. Epub 2021 May 12.

Department of Pathology, UT Southwestern Medical Center, Dallas, TX, USA.

Microsecretory adenocarcinoma (MSA) is a recently described salivary gland tumor with a characteristic histologic and immunophenotypic profile and recurrent MEF2C-SS18 fusions. Because only six cases of MSA have been published, its complete clinicopathologic spectrum is unclear, and its biologic behavior has not been documented. Here, we present an updated and expanded experience of 24 MSA cases. Read More

NPJ Genom Med 2021 May 12;6(1):32. Epub 2021 May 12.

National Institute of Biomedical Genomics, Kalyani, India.

Oral squamous cell carcinoma of the gingivo-buccal region (OSCC-GB) accounts for the highest cancer morbidity and mortality among men in India. It has been observed that about one-third of individuals with oral leukoplakia, a dysplastic precancerous lesion in the oral cavity, progress to oral cancer. We aimed to identify systematic transcriptomic changes as a normal tissue in the oral cavity progresses to frank OSCC-GB. Read More

Vet Med Sci 2021 May 5. Epub 2021 May 5.

Department of Intensive Care Medicine, Qingdao Municipal Hospital, Qingdao, China.

Background: Newly, chemo-preventive technique might be a hopeful advancement in developing countries for treating cancers with the aid of toxic less natural based constituents. Malignancy urges to augment effectual chemo-preventive agents that are look forward to suppress the tumours which may be stimulated by chewing and smoking of tobacco and over alcohol consumption related with the high prevalence of human oral cancer (OC) patients.

Methods: In the present research, we examined to assess antioxidants, lipid peroxidation (LPO) and detoxification enzymes levels of anticancer activity of mangiferin on 0. Read More

Oral Oncol 2021 Apr 30;118:105316. Epub 2021 Apr 30.

Department of Surgical Oncology, All India Institute of Medical Sciences, Rishikesh, India. Electronic address:

Introduction: Though the submandibular gland (SMG) is routinely sacrificed for several reasons during neck dissection in patients undergoing curative surgery for oral cavity cancers, it might be an innocent bystander and should be considered for preservation. This study aimed to identify the incidence, different patterns of invasion, and risk factors of SMG involvement in oral cavity squamous cell carcinoma (SCC).

Methods: This was a retrospective study of the patients who underwent upfront curative surgery for a biopsy-proven oral cavity SCC. Read More

Turk J Gastroenterol 2021 Jan;32(1):42-52

Division of Gastroenterology and Hepatology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Background/aims: Patients with achalasia have a high incidence of esophageal squamous cell carcinoma (ESCC), which may be associated with alterations in oral and esophageal microbiota caused by food stasis. This study compared the oral and esophageal microbiota of patients with achalasia before and after peroral endoscopic myotomy (POEM). It also compared patients with achalasia to those with ESCC. Read More

Int J Gen Med 2021 15;14:1311-1323. Epub 2021 Apr 15.

Department of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, Mecca, 21955, Saudi Arabia.

Purpose: Colorectal carcinoma (CRC) represents a considerable public health burden in Saudi Arabia. Several candidate genes and genetic variants have been associated with morbidity and mortality among patients with CRC. We explored whether allelic variants of the (rs4646903 and rs1048943), and (rs1042522) genes predisposed nonsmoking Saudi individuals to increased risk for CRC. Read More

Ocul Oncol Pathol 2021 Mar 21;7(2):108-120. Epub 2021 Jan 21.

Nebraska Center for Virology and the School of Biological Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska, USA.

Aim: This study aimed to characterize the clinical and pathologic presentation of ocular surface tumors (OSTs) and to more precisely differentiate the grades of ocular surface squamous neoplasia (OSSN) and benign lesions among Zambians.

Methods: Two-hundred sixty-five Zambian patients presenting with ocular surface growths, suspicious for OSSN, were recruited between November 2017 and November 2019 to a cross-sectional study to investigate their lesions. Sociodemographic data were collected, HIV infection status and vision tests were performed, and lesions were measured and documented. Read More

Pathol Int 2021 Apr 13. Epub 2021 Apr 13.

Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.

Secretory carcinoma or mammary analog secretory carcinoma is an entity of salivary gland carcinoma that is characterized by the ETV6-NTRK3 gene fusion. Although it is generally considered to be a low-grade malignancy, some cases of secretory carcinoma with high-grade transformation (SCHG) have been reported. We herein describe a case of SCHG composed almost exclusively of the high-grade component. Read More

Int J Appl Basic Med Res 2021 Jan-Mar;11(1):47-49. Epub 2021 Jan 26.

Department of Head and Neck Oncology, Karnataka Cancer Therapy and Research Institute, Hubli, Karnataka, India.

We present a rare case of simultaneous occurrence of pleomorphic adenoma of the left parotid gland and squamous cell carcinoma (SCC) of left buccal mucosa in a 59-year-old patient. The synchronous occurrence of these two entities has not been reported in the literature. A PubMed database search did not yield any results for search words involving "Oral Cancer," "Synchronous Oral Cancer and Pleomorphic Adenoma of Parotid gland" and "Oral SCC and Pleomorphic Adenoma of Parotid gland. Read More

Oral Maxillofac Surg 2021 Apr 10. Epub 2021 Apr 10.

Department of Oral and Maxillofacial Surgery, People's Dental Academy, People's University, Karond By-Pass, Bhanpur, Bhopal, 462 037, India.

Background: In early stage buccal mucosa carcinoma, in spite of successful curative surgery, the health-related quality-of-life (HRQoL) may not improve. We aimed to study HRQoL in these patients who had undergone successful curative surgery and determined factors that influence the HRQoL.

Methods: Subjects, aged 18-70 years, who had undergone successful curative surgery for stage I and II buccal mucosa cancer, were assessed for HRQoL using the University of Washington Quality of Life Questionnaire and factors affecting HRQoL were determined. Read More

Acta Dermatovenerol Croat 2020 Dec;28(7):238-239

Georgia Kyriakou, MD, MsC, cPhD., Department of Dermatology, University General Hospital of Patras, University General Hospital of Patras, Rion 265 04, Greece;

A 45-year-old HIV-negative Caucasian man with no reported past medical history was referred to our Department with a large (7 cm in diameter) oozing nodule on the occipital region of the scalp with spontaneous periodical bloody or purulent discharge. The lesion had appeared over a period of six months, had an irregular color, non-specific dermoscopic features, and resembled squamous cell carcinoma. The physical examination revealed three more atypical melanocytic lesions (on the abdomen, back, and buccal mucosa), and multiple swollen occipital, postauricular, as well as superficial and deep cervical lymph nodes. Read More

Medicine (Baltimore) 2021 Apr;100(14):e25458

Department of Head and Neck Cancer Center.

Rationale: The free fibular flap is considered the gold standard, particularly for a mandibular defect combined with a significant soft tissue defect. However, the fibular flap has the disadvantages of a lack of height for postoperative dental restoration and donor site skin graft if the skin paddle is wider than 5 cm. The larger bone and soft tissue defects tend to be reconstructed using either a scapula or a combination of iliac artery and radial free flap. Read More

Int J Dermatol 2021 Apr 7. Epub 2021 Apr 7.

Dermatology Clinic, Maggiore Hospital of Trieste, Trieste, Italy.

Background: Basal cell carcinoma (BCC) and dermal nevi located on the face can easily be confused on clinical examination. Little is known about the different preferential localizations of these entities, and a systematic analysis of dermatoscopic features for differential diagnosis is lacking.

Methods: Clinical and dermatoscopic images of BCCs and dermal nevi were retrospectively evaluated to study their relation to various face anatomical areas, BCC histotype, classic and nonclassic dermatoscopic BCC criteria, as well as typical dermatoscopic criteria for dermal nevi. Read More

Bosn J Basic Med Sci 2021 04 2. Epub 2021 Apr 2.

Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia.

The objective of the present article was to qualitatively and quantitatively review the association between chronic mechanical irritation and oral squamous cell carcinoma (OSCC). PubMed, SCOPUS, and Web of Science databases were searched using the keyword combinations "chronic trauma and oral squamous cell carcinoma; chronic irritation and oral squamous cell carcinoma; chronic irritation and oral cancer; and chronic trauma and oral cancer." Duplicates and irrelevant articles were excluded after the title and abstract screening. Read More

J Oral Pathol Med 2021 Apr 5. Epub 2021 Apr 5.

Oral Pathology, School of Dentistry, Rio de Janeiro State University, Rio de Janeiro, Brazil.

Background: To analyse the clinical and histological characteristics from a series of oral leukoplakias, leukoerythroplakias, erythroplakias and actinic cheilitis diagnosed in a 14-year period.

Methods: The files were reviewed and all cases diagnosed as leukoplakia, leukoerythroplakia, erythroplakia and actinic cheilitis were selected. Clinical information was obtained from the biopsy submission forms, and histological review was performed in all cases. Read More

Indian J Plast Surg 2021 Jan 30;54(1):53-57. Epub 2020 Nov 30.

Department of Head and Neck Surgery, TATA Medical Center, Kolkata, West Bengal, India.

 The process of reconstruction of tracheal defects is complex and still not optimum. Options range from using staged reconstructions, combining flaps with autologous or alloplastic implants, as well as use of tissue-engineered constructs combined with vascularized tissues which are lined with cell cultures. Staged reconstructions using prelaminated epithelium, and prefabricated flaps, help in reconstruction of this complex structure. Read More

J Oral Pathol Med 2021 Apr 2. Epub 2021 Apr 2.

University of Hong Kong, Hong kong, China.

Background: Oral squamous cell carcinoma (OSCC) is the 15th most common cause of cancer-related mortality worldwide and approximately one oral cancer-related death occurs for every two new diagnoses. Death-due-to-disease is usually ascribed to inoperable primary tumours, treatment complications, second primary tumours arising due to field cancerization, or locoregional recurrence and distant metastases.

Methods: A retrospective review of OSCC patients treated over a 19-year period, betweenOctober 1 , 2000 and October 1 , 2019. Read More

Head Neck Pathol 2021 Apr 2. Epub 2021 Apr 2.

Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.

Oral squamous cell carcinoma (OSCC) occasionally occurs in young patients and is likely to be distinct from OSCC in older patients. In this retrospective study, we described the clinicopathologic features and outcome of 150 OSCCs that were diagnosed in patients 40-year-old or younger. Most patients (63%) were non-smokers. Read More

Maxillofac Plast Reconstr Surg 2021 Mar 17;43(1):10. Epub 2021 Mar 17.

Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Jukheon gil 7, Gangneung, Gangwondo, 25457, Republic of Korea.

Background: Pedicled buccal fat pad (PBFP) has been used for the reconstruction of small-sized maxillary defects but cannot be used without hard tissue support on the defect larger than 4 cm × 4 cm × 3 cm.

Case Presentation: A 64-year-old man had a history of squamous cell carcinoma of the left maxilla. After removal of the posterior maxilla, a complex bone defect (size, 5 cm × 4 cm × 3 cm) was immediately reconstructed using PBFP combined with a titanium mesh. Read More

Cureus 2021 Feb 8;13(2):e13214. Epub 2021 Feb 8.

Internal Medicine, Rutgers New Jersey Medical School, Newark, USA.

Herpes simplex virus (HSV) and cytomegalovirus (CMV) infections are commonly seen in immunocompromised patients, particularly in patients with HIV. However, fulminant CMV infection and concurrent infection with HSV and CMV in non-HIV patients are quite rare. We present the case of a 72-year-old HIV-negative man with a history of oropharyngeal carcinoma in remission and recent treatment of immune thrombocytopenic purpura with high-dose steroids who was transferred from an outside hospital for Ear Nose and Throat (ENT) evaluation of a non-healing buccal ulcer. Read More

BMC Surg 2021 Mar 8;21(1):120. Epub 2021 Mar 8.

Plastic Surgery Department, Shifa International Hospital, Pitras Bukhari Road H-8, Islamabad, Pakistan.

Background: Most of the head and neck cancers are time-critical and need urgent surgical treatment. Our unit is one of the departments in the region, at the forefront in treating head and neck cancers in Pakistan. We have continued treating these patients in the COVID-19 pandemic with certain modified protocols. Read More

Oral Oncol 2021 Mar 1:105246. Epub 2021 Mar 1.

Head and Neck Oncology, Mazumdar Shaw Medical Center, Bangalore, India. Electronic address:

Folia Med (Plovdiv) 2021 Feb;63(1):42-50

Private Safa Hospital, Istanbul, Turkey.

Introduction: Minimal invasive endo-urologic interventions and prostate surgeries performed through the urethral route are the most commonly used surgeries in the urology field at present. One of the unwanted complications weeks after some of these surgeries is urethral stenosis.

Aim: In this study, we aimed to review our treatment methods for patients with urethral stricture occurring after urologic interventions retrospectively to evaluate our success rates and data predicting recurrence and to determine the most feasible method. Read More

Head Neck Pathol 2021 Feb 5. Epub 2021 Feb 5.

Department of Oral Pathology, Nair Hospital Dental College, Mumbai, 400008, India.

Connective tissue growth factor (CTGF), a matricellular protein of the CCN family of extracellular matrix-associated heparin-binding proteins, is highly expressed in various organ fibrosis and several malignant tumors. Although a few studies have been conducted using CTGF in oral submucous fibrosis (OSF) and oral squamous cell carcinoma, no study has demonstrated its relation with various stages of OSF and its malignant transformation. The present study investigated the possible role of CTGF in the pathogenesis of OSF and its malignant transformation by using immunohistochemistry. Read More

Auris Nasus Larynx 2021 Jan 29. Epub 2021 Jan 29.

Department of radiation oncology, Kaohsiung Veterans General Hospital, No.386, Dazhong 1st Rd., Zuoying Dist., Kaohsiung City 81362, Taiwan; School of medicine, National Defense Medical Center, Taipei, Taiwan; Department of Nursing, Meiho University, Pingtung, Taiwan. Electronic address:

Purpose: To evaluate the contralateral lymph node recurrence rate (clLNRR) of stage IVA to IVB well-lateralized oral cavity cancer. To evaluate the risk factors of clLNRR.

Materials And Methods: Pathologic stage IVA-B squamous cell carcinoma of oral cavity, originating from buccal mucosa, gingiva, or retromolar trigone were retrospectively recruited. Read More

Oral Surg Oral Med Oral Pathol Oral Radiol 2021 May 8;131(5):582-590. Epub 2021 Jan 8.

Department of Radiology, The Jikei University School of Medicine, Minato-ku, Tokyo, Japan.

Objective: The objective of this study was to determine correlations between magnetic resonance imaging (MRI) features including radiologic depth of invasion (r-DOI) and pathologic DOI (p-DOI) of squamous cell carcinoma of the buccal mucosa.

Study Design: In total, 31 lesions were retrospectively evaluated. MRI findings included detectability, buccinator muscle invasion (positive: BMI+, negative: BMI-), buccal fat pad invasion (positive: BFPI+, negative: BFPI-), and r-DOI measured on T2-weighted images (T2-DOI) and contrast-enhanced T1-weighted images (CET1-DOI). Read More

Clin Case Rep 2021 Jan 21;9(1):23-30. Epub 2020 Nov 21.

Oral and Maxillofacial Pathology Department School of Dentistry Tehran University of Medical Sciences Tehran Iran.

In the oral cavity, adenoid cystic carcinomas of the buccal mucosa are extremely rare. Minor salivary grand adenoid cystic carcinoma should receive aggressive treatment to achieve negative surgical margins to inhibit recurrence. Read More

BMC Oral Health 2021 01 22;21(1):40. Epub 2021 Jan 22.

Department of Oral and Maxillofacial Surgery, Nagoya Ekisaikai Hospital, 4-66 Syounen-cho Nakagawa-ku, Nagoya, 454-8502, Japan.

Background: The systemic inflammatory response and nutritional status of patients with malignant tumors are related to postoperative results. We examined the usefulness of the prognostic nutritional index (PNI) as a prognostic tool in patients with oral squamous cell carcinoma who underwent radical surgery.

Methods: From 2008 to 2019, 102 patients (73 males, 29 females; age, 65. Read More

Adv Biomed Res 2020 30;9:48. Epub 2020 Sep 30.

Department of Pathology, Indira Gandhi Medical College and Research Institute, Puducherry, India.

Background: Chronic alcohol consumption carries a high risk for oral and pharyngeal cancers among persons who have never smoked. Excessive alcohol consumption displays cytogenetic changes in oral mucosa cells. Cytomorphometric analysis of oral mucosal cells helps in the early detection of cytomorphological transformations in alcoholics before and after the onset of carcinoma. Read More

J Oral Maxillofac Pathol 2020 May-Aug;24(2):237-244. Epub 2020 Sep 9.

Medical Officer, Bangalore Branch, Indian Cancer Society, Bengaluru, Karnataka, India.

Background: The association between potentially premalignant oral epithelial lesions (PPOEL), oral squamous cell carcinoma and its higher incidence in South-East Asian population due to the use of arecanut, pan, slaked lime and tobacco is well known. The study was carried out in urban and rural population of Bengaluru, Karnataka, to assess and correlate the pattern of habit, clinical presentation and cytological grading of PPOELs, attempting at identifying the main arms associated with risk of malignant transformation.

Aims: Assessment of history, clinical presentation of PPOELs, co-relate with cytological grades and escalate to binary risk assessment. Read More