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Oral Oncol 2020 May 7;107:104749. Epub 2020 May 7.

Department of Otorhinolaryngology, Careggi University Hospital, Florence, Italy.

Background: Depth of invasion (DOI) has been introduced into the latest TNM classification of oral squamous cell carcinoma (OSCC). Despite its primarily pathological definition (pDOI), a preoperative evaluation of a radiological DOI (rDOI) would be useful but a standard and practical definition is lacking. The primary aim of this study is to measure the rDOI by computed tomography (CT) and compare it to the pDOI in a cohort of OSCC patients. Read More

J Oral Maxillofac Surg 2020 Apr 10. Epub 2020 Apr 10.

Full Professor, Department of Surgical Pathology, Medicine, Molecular and Critical Area, University of Pisa, Pisa, Italy.

The localization of renal cell carcinoma (RCC) metastases in the oral cavity has been reported, accounting for about 15% of patients with metastasizing renal disease. In this work, we report 2 cases of oral metastases of renal carcinoma and provide a review of the current literature on the occurrence of oral metastases of renal origin. The first patient (a 62-year-old man) presented with a tumefaction of the body of the tongue. Read More

Oral Oncol 2020 May 1;107:104710. Epub 2020 May 1.

Department of Periodontology, School of Stomatology, China Medical University, Shenyang, China. Electronic address:

Objectives: Previous studies have proved that periodontitis is an independent risk factor of oral squamous cell carcinoma (OSCC) epidemiologically. Along with the important role of microbiota in the cancer process and the specific anatomical position, our study explored the microbial composition and functions in periodontitis and gingival squamous cell carcinoma (GSCC).

Materials And Methods: GSCC patients (n = 10), matched periodontitis patients (n = 15), and healthy individuals (n = 15) were recruited. Read More

J Clin Imaging Sci 2020 2;10:27. Epub 2020 May 2.

Department of Oral Medicine and Maxillofacial Radiology, Faculty of Dental Medicine, Lebanese University, Beirut, Lebanon.

Metastatic lesions to the oral cavity are uncommon; they represent between 1 and 3% of all malignant oral neoplasms. In this article, we report a rare case of metastatic urothelial bladder carcinoma in the mandible detected on oral radiographic images and confirmed with multiple imaging modalities. A 67-year-old woman presented to our clinic suffering from pain in the right side of the mandible with a mild swelling. Read More

J Dent 2020 Jun 25;97:103343. Epub 2020 Apr 25.

Prosthodontics, Faculty of Dentistry, the University of Hong Kong, Hong Kong SAR, China. Electronic address:

Objectives: This study was conducted to examine the tooth wear status of nasopharyngeal-carcinoma (NPC) patients who had received radiotherapy at least 5-year previously, and to investigate the salivary parameters that may be associated with the tooth wear.

Methods: Tooth wear status of NPC survivors were clinically assessed using the Exact Tooth Wear Index. A tooth was graded to have severe wear when more than one-third of its buccal/occlusal/lingual surface had dentine loss. Read More

Hua Xi Kou Qiang Yi Xue Za Zhi 2020 Apr;38(2):133-138

Oral & Maxillofacial Reconstruction Laboratory, Southwest Medical University, Luzhou 646000, China;Dept. of Periodontal Mucosal Disease, The Affiliated Stomatology Hospital of Southwest Medical University, Luzhou 646000, China.

Objective: This work aimed to determine the expression changes in LIM domain only protein 1 (LMO1) in gene transcription and protein levels during oral squamous cell carcinoma (OSCC) development.

Methods: The tissues in this study were taken from our team's previous animal model building, and we performed hematoxylin-eosin (HE) staining on 49 cases. The pathological classification of the experiment group was determined on the basis of the abnormal epithelial hyperplasia degree. Read More

J Oral Maxillofac Surg 2020 Mar 14. Epub 2020 Mar 14.

Professor and Department Head, Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, China. Electronic address:

Purpose: Radical resection of buccal carcinoma frequently leads to intraoral or through-and-through buccal defects. Anterolateral thigh (ALT) flaps can be harvested to reconstruct different buccal defect subtypes. The purpose of this study was to investigate clinical outcomes after the application of personalized ALT flaps for the precise reconstruction of unilateral buccal defects. Read More

J Dent Sci 2020 Mar 25;15(1):112-113. Epub 2019 Sep 25.

School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

J Dent Sci 2020 Mar 17;15(1):92-95. Epub 2019 Oct 17.

Division of Oral Pathology & Maxillofacial Radiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.

Background/purpose: Oral metastatic carcinomas are rarely found in oral soft tissues. This study reported the clinicopathological features of 13 intraoral soft tissue metastatic carcinomas.

Materials And Methods: A total of 13 intraoral soft tissue metastatic carcinomas were included in this study. Read More

Int Arch Otorhinolaryngol 2020 Apr 4;24(2):e125-e131. Epub 2019 Nov 4.

Department of Pathology, Post-Graduate Institute of Medical Education and Research, Chandigarh, Chandigarh, India.

 The efficacy of sentinel node biopsy in early stage oral cancer is well established. Its evolving role can be reinforced by further studies.  Analyzing the predictability of the levels of echelon nodes for various oral cavity tumor subsites on sentinel node biopsy. Read More

Cells 2020 Mar 26;9(4). Epub 2020 Mar 26.

Department of Oral Implantology and ProstPhetic Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam (UvA) and Vrije Universiteit Amsterdam (VU), Gustav Mahlerlaan 3004, 1081 LA Amsterdam, The Netherlands.

Human salivary histatin 1 (Hst1) and Hst2 exhibit a series of cell-activating properties (e.g., promoting adhesion, spreading, migration and metabolic activity of mammalian cells). Read More

Indian J Surg Oncol 2020 Mar 25;11(1):86-91. Epub 2019 Nov 25.

4Department of Radiation Oncology, All India Institute of Medical Sciences, New Delhi, India.

Oral Squamous cell carcinoma (OSCC) is a locoregionally aggressive malignancy. Timely management of neck node dissemination, an important prognostic factor, impacts survival. The aim of the current study was to obtain comprehensive data on patterns or level-wise involvement of neck nodes to optimize neck management in OSCC. Read More

Ann Hepatobiliary Pancreat Surg 2020 Feb 27;24(1):68-71. Epub 2020 Feb 27.

GI and HPB Services, Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, India.

Hepatocellular carcinoma, a disease of the developing world, is known to present with extrahepatic metastases. Most common site being the lungs, it is not uncommon for metastases to present at unusual sites like the rectum, spleen and the diaphragm, among others. Metastases to the oral cavity is rare, with the most common primaries being lung, breast and the kidney. Read More

Biomed Res Int 2020 13;2020:1470868. Epub 2020 Feb 13.

Department of Pharmacy, Sciences Faculty, Universidad Nacional de Colombia, Bogotá 111321, Colombia.

Objectives: To investigate the effect of systemic administration of the immunosuppressant dexamethasone (DM) while inducing hamster buccal pouch DMBA carcinogenesis. . Two different experiments were performed. Read More

Pak J Med Sci 2020 Jan-Feb;36(2):126-130

Dr. Irfan Ahmed Shaikh, FCPS, Assistant Professor ENT. Department of ENT Head & Neck Surgery, Dow University of Health Sciences & Dr. Ruth K. M. Pfau, Civil Hospital Karachi, Karachi, Pakistan.

Background &objectives: Transient paralysis of facial nerve is seen to vary from 15 % to 66 % in post-parotid surgery. The objective of this study was to find out the complications in post-parotidectomy with regards to facial nerve dysfunction since it is a vital structure encountered in parotid surgeries.

Methods: This was a retrospective study through non probability convenient sampling technique carried from September 2010 to January 2019 in the Department of Otorhinolaryngology, Dow University of Health Sciences, Dr. Read More

Acta Otolaryngol 2020 May 12;140(5):427-432. Epub 2020 Feb 12.

Department of Oncology, Xiangya Hospital, Central South University, Changsha, China.

We aimed to preserve parotid function in patients with buccal carcinoma by applying a new surgical protocol based on reconstruction of parotid ductal defect with submandibular gland ductal. The aim of this study is to introduce the method of autologous submandibular gland duct reconstruction for the treatment of parotid duct defect in buccal carcinoma, and to evaluate its clinical application in follow-up. A total of 28 patients with buccal carcinoma who underwent buccal and neck combined with radical surgery and vascularized flap transplantation were enrolled. Read More

Head Neck Pathol 2020 Feb 3. Epub 2020 Feb 3.

Guy's and St Thomas' NHS Foundation Trust, Oral/Head and Neck Pathology, King's College London, Guy's Hospital, 4th Floor Tower Wing, London, SE19RT, UK.

The juxtaoral organ of Chievitz (JOOC) is a part of microanatomy composed of bland epithelial islands closely associated with small nerves and usually described within the soft tissue on the lingual aspect of the posterior mandible. Similar structures are documented in the posterior tongue. There is a risk of misinterpretation as carcinoma showing perineural invasion. Read More

Front Cell Infect Microbiol 2019 15;9:476. Epub 2020 Jan 15.

Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

The oral microbiota plays an important role in the human microbiome and human health, and imbalances between microbes and their hosts can lead to oral and systemic diseases and chronic inflammation, which is usually caused by bacteria and contributes to cancer. There may be a relationship between oral bacteria and oral squamous cell carcinoma (OSCC); however, this relationship has not been thoroughly characterized. Therefore, in this study, we compared the microbiota compositions between tumor sites and opposite normal tissues in buccal mucosal of 50 patients with OSCC using the 16S rDNA sequencing. Read More

Front Immunol 2019 15;10:3095. Epub 2020 Jan 15.

Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, United States.

Head and neck squamous cell carcinoma (HNSCC) is a prevalent form of cancer with 5-years survival rates around 57%, and metastasis is a leading cause of mortality. Host-derived immunological factors that affect HNSCC tumor development and metastasis are not completely understood. We investigated the role of host-derived signal transducer and activator of transcription 4 (STAT4) during experimental HNSCC using an aggressive and metastatic HNSCC cell line, LY2, which was orthotopically injected into the buccal sulcus of wild type (WT) and STAT4 deficient () BALB/c mice. Read More

Int J Radiat Biol 2020 May 6;96(5):577-583. Epub 2020 Feb 6.

Clinical Department, Southern Urals Biophysics Institute, Ozyorsk, Chelyabinsk Region, Russia.

Characteristics of biological specimens donated by nuclear workers with lung cancer. Biological specimens were identified at the Radiobiological Human Tissue Repository (RHTR). It was established at the Southern Urals Biophysics Institute in Russia and has been developed and supported within the bilateral US-Russian Agreement on International Cooperation for Minimization of the Effects of Prolonged Radiation Exposure. Read More

J Cytol 2020 Jan-Mar;37(1):53-57. Epub 2019 Dec 23.

Department of ENT, Maulana Azad Medical College, New Delhi, India.

Objective: To evaluate the utility of intraoral fine-needle aspiration cytology (FNAC) in diagnosis of minor salivary gland neoplasms (MSGN) with application of Milan system of reporting salivary gland cytopathology; keeping histopathology as gold standard and to detail the cytological findings of MSGNs.

Method: Retrospective study between Jan 2008 and June 2017 (appro × 10 years) on the cytology of the minor salivary gland tumor along with the histopathological correlation. The relevant clinical data was collected from the medical record. Read More

J Otolaryngol Head Neck Surg 2020 Jan 15;49(1). Epub 2020 Jan 15.

The Department of Otolaryngology - Head sand Neck Surgery, University of Ottawa, 501 Smyth Rd, Ottawa, ON, K1H 8L6, Canada.

Following publication of the original article [1], the authors reported that one of the authors' names was spelled incorrectly. In this Correction the incorrect and correct author name are shown. The original publication of this article has been corrected. Read More

Clin Epigenetics 2020 Jan 13;12(1):12. Epub 2020 Jan 13.

Division of Disease Control and Molecular Epidemiology, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido, Hokkaido, 061-0293, Japan.

Background: DNA hypermethylation of tumor suppressor genes is observed in precancerous lesions and oral cancer of individuals with the habits of betel quid (BQ) chewing. SIRT1 has been identified as playing a role in the maintenance of epithelial integrity, and its alteration is often related to carcinogenesis. However, the methylation and transcription status of SIRT1 in patients with BQ chewing-related oral cancer has not been investigated. Read More

Exp Mol Pathol 2020 Apr 11;113:104378. Epub 2020 Jan 11.

The Gujarat Cancer & Research Institute, M.P. Shah Cancer Hospital, Civil Hospital Campus, Asarwa, Ahmedabad, Gujarat, India. Electronic address:

Background: High recurrence and poor overall survival in buccal mucosa squamous cell carcinoma (BMSCC) are not well addressed due to lack of efficient prognostic biomarkers and targeted therapies. To uncover gene candidates for the same, transcriptome profiling has been examined in BMSCC, which is not explored yet.

Methods: We compared 9 BMSCC and 2 normal oral FFPE tissues using Agilent SurePrint G3 Human gene expression v3 microarray chips. Read More

Indian J Cancer 2020 Jan-Mar;57(1):62-69

Department of Head and Neck Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.

Purpose: In India, head and neck cancer contributes to about 35% of all malignancies. Among head and neck squamous cell cancers, buccal mucosa and tongue are the most common subsites. Reconstruction of defects after resection of primary in these subsites with acceptable cosmetic and functional outcomes remains a challenging task. Read More

Mymensingh Med J 2020 Jan;29(1):149-155

Dr Hasib Rahman, Associate Professor, Plastic Surgery, Sylhet MAG Osmani Medical College and Hospital, Sylhet, Bangladesh; E-mail:

Reconstruction of total lip is a challenging task for a plastic surgeon. It becomes more complicated when there is loss of additional tissues like angle of mouth, buccal mucosa or floor of the mouth. Radial forearm flap with palmaris longus tendon provides an easier but reliable technique for three dimensional lip reconstructions with good functional and aesthetic outcome. Read More

Ann Maxillofac Surg 2019 Jul-Dec;9(2):444-450

Department of Oral and Maxillofacial Surgery, P.M.N.M. Dental College, Bagalkot, Karnataka, India.

The various surgical procedures for surgical management of oral submucous fibrosis (OSMF) include excision of fibrous bands with or without grafts or flaps. Materials for attempted grafting included skin, placental grafts, and artificial dermis. Materials that can be used as flaps are tongue flaps, buccal fat pad, greater palatine pedicle flaps nasolabial flaps, anterolateral thigh flap, radial forearm flap, and temporalis fascia flap. Read More

Ann Maxillofac Surg 2019 Jul-Dec;9(2):364-370

Department of Oral Oncology, Kidwai Cancer Institute, Bengaluru, Karnataka, India.

Background: Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy worldwide and is the major public health problem in the Indian subcontinent, where it ranks among the top three types of cancer in the country. Here, we aimed to analyze the clinical and tumor characteristics which impact the survival of OSCC patients.

Methods: A retrospective analysis of clinical records of all patients who underwent treatment for OSCC at Kidwai Memorial Institute of Oncology, between January 2009 and January 2012 was analyzed. Read More

Ann Maxillofac Surg 2019 Jul-Dec;9(2):247-252

Department of Oral Medicine and Radiology, Rajarajeshwari Dental College and Hospital, Bengaluru, Karnataka, India.

Introduction: Oral submucous fibrosis is a chronic debilitating condition with potential for malignant transformation. Squamous cell carcinoma arising from a background of oral submucous fibrosis presents clinically as a distinct disease due to different etiopathogenesis.

Methodology: This prospective case series describes thirty cases of oral squamous cell carcinoma (OSCC) alongside oral submucous fibrosis (OSF). Read More

Clin Oral Investig 2020 Jan 6. Epub 2020 Jan 6.

Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.

Objective: Chewing betel quid (CBQ) is popular in Southeast Asia, resulting in a high incidence of oral squamous cell carcinoma (OSCC). The incidence of multiple primary oral cancer (MPOC) has gradually increased and has become one of the main causes of OSCC treatment failure. However, it is unclear whether the high incidence of MPOC is also correlated with the habit of CBQ. Read More

J Otolaryngol Head Neck Surg 2019 Dec 30;48(1):73. Epub 2019 Dec 30.

The Department of Otolaryngology - Head and Neck Surgery, University of Ottawa, 501 Smyth Rd, Ottawa, ON, K1H 8L6, Canada.

Objective: To systematically review the evidence to evaluate oncologic outcomes for patients with early stage buccal squamous cell carcinoma treated with surgery versus surgery and adjuvant radiation therapy.

Data Sources: Ovid MedLine, EMBASE, Google Scholar, PubMed.

Review Methods: The primary purpose was to perform a systematic review to determine the published literature comparing oncologic outcomes of patients with early stage (Stages I&II) buccal mucosal squamous cell carcinoma, treated with surgical resection alone versus surgery plus adjuvant radiation therapy. Read More

Beilstein J Nanotechnol 2019 25;10:2304-2328. Epub 2019 Nov 25.

Laboratory of Research and Development of Drug Delivery Systems, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, State University of Maringa, Maringa, Brazil.

Mucoadhesive nanostructured systems comprising poloxamer 407 and Carbopol 974P have already demonstrated good mucoadhesion, as well as improved mechanical and rheological properties. Curcumin displays excellent biological activity, mainly in oral squamous cancer; however, its physicochemical characteristics hinder its application. Therefore, the aim of this study was to develop nanostructured formulations containing curcumin for oral cancer therapy. Read More

Case Rep Hematol 2019 23;2019:6015803. Epub 2019 Nov 23.

Department of Oral and Maxillofacial Surgery, Okazaki City Hospital, Okazaki, Japan.

Peripheral blood stem cell transplantation (PBSCT) has increasingly been used for hematologic cancer therapy, resulting in improved survival rates. However, risks include graft-versus-host disease (GVHD) and secondary solid tumors. Here, we describe a case of tongue squamous cell carcinoma (SCC) complicated by bronchiolitis obliterans (BO) following PBSCT. Read More

Hua Xi Kou Qiang Yi Xue Za Zhi 2019 Dec;37(6):621-625

Dept. of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: This study investigated the feasibility and clinical result of radical resection of posterior buccal carcinoma by using the facial nasolabial fold "smile" incision approach.

Methods: From August 2016 to March 2017, 23 patients with posterior buccal carcinoma were included in this study and underwent radical surgery. Upon finishing the cervical lymph node dissection, an arc-shaped incision was made at 1 cm lateral to the ipsilateral angulus oris, extending along the nasolabial fold upward to the inferolateral margin of the nasal alar while downward in direct continuity with the neck dissection incision. Read More

Microsurgery 2019 Dec 23. Epub 2019 Dec 23.

Department of Plastic and Reconstructive Surgery, University of Tsukuba, Tsukuba, Japan.

Background: Oral modiolus reconstruction is important in unilateral oral commissure removal including the modiolus. However, the proper procedure is not yet established. We performed free-flap reconstruction for full-thickness oral defects involving the oral commissure combined with oral modiolus reconstruction using a fascial sling. Read More

Int J Oral Maxillofac Surg 2019 Dec 15. Epub 2019 Dec 15.

Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory, Sun Yat-sen University, Guangzhou, China. Electronic address:

The facial artery pedicle nasolabial island flap (FAPNIF) is widely used for oral and maxillofacial reconstruction. However, its use in reconstruction after malignant tumour resection is limited by the possibility of ipsilateral cervical lymph node metastasis along the facial artery. Through fine dissection, it was found that the contralateral FAPNIF can be used to repair the defect after buccal carcinoma resection. Read More

Cancer Lett 2020 Mar 10;472:1-7. Epub 2019 Dec 10.

Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Bellaterra, Barcelona, Spain; Center for Biomedical Network Research on Rare Diseases (CIBERER), Madrid, Spain; Sant Pau Biomedical Research Institute, Sant Pau Hospital, Barcelona, Spain; Department of Genetics, Sant Pau Hospital, Barcelona, Spain. Electronic address:

Fanconi anemia (FA) is a rare genome instability syndrome characterized by progressive bone marrow failure and predisposition to cancer, especially head and neck squamous cell carcinoma. Surgical resection is the standard of care for solid tumors, as patients with FA do not tolerate genotoxic chemotherapies or radiation, leading to poor prognosis. It is therefore imperative to develop chemoprevention strategies such as the identification of novel biomarkers to detect the formation of the tumor before its emergence and to use them in clinical trials aimed to counteract genome instability of patients with FA in tissues at risk. Read More

Clin Epigenetics 2019 12 3;11(1):178. Epub 2019 Dec 3.

National Institute of Biomedical Genomics, P.O.: N.S.S, Kalyani, 741251, India.

Background: Gingivo-buccal oral squamous cell carcinoma (OSCC-GB) is the most common cancer among men in India and is associated with high mortality. Although OSCC-GB is known to be quite different from tongue cancer in its genomic presentation and its clinical behavior, it is treated identically as tongue cancer. Predictive markers of prognosis and therapy that are specific to OSCC-GB are, therefore, required. Read More

World J Surg Oncol 2019 Nov 27;17(1):198. Epub 2019 Nov 27.

Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221005, India.

Oral squamous cell cancer (OSCC) is a common malignancy attributed to use of chewing smokeless tobacco and smoking. Most of the targeted strategies are based on EGFR expression and mutation; however, none of them has shown significant improvement in survival and response rates. We carried out this study to evaluate mutational profile of tobacco associated oral carcinoma with special emphasis on EGFR and its downstream events. Read More

BMJ Case Rep 2019 Nov 25;12(11). Epub 2019 Nov 25.

Department of Urology, Epworth Freemasons, East Melbourne, Victoria, Australia.

A 56-year-old man was referred to a reconstructive urologist for evaluation of a tender nodule in the penoscrotal area. Penile Doppler ultrasound showed a non-compressible mass with internal vascularity within the corpora spongiosum, and MRI identified an enhancing, solid mass arising from the ventral aspect of the urethra. Surgical resection warranted partial excision and reconstruction of the urethra, which was achieved by a dorsal onlay buccal mucosal graft urethroplasty through a perineal incision with penile invagination. Read More

Cancers (Basel) 2019 Nov 23;11(12). Epub 2019 Nov 23.

Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.

Oral squamous cell carcinoma (OSCC) is one of the major leading causes of cancer death worldwide due to the limited availability of biomarkers and therapeutic targets. Autophagy related protease 4B (ATG4B) is an essential protease for the autophagy machinery, and ATG4B phosphorylation at Ser383/392 increases its proteolytic activity. ATG4B expression and activation are crucial for cancer cell proliferation and invasion. Read More

Indian J Otolaryngol Head Neck Surg 2019 Nov 24;71(Suppl 3):2082-2086. Epub 2018 Aug 24.

Department of ENT, SDUMC, Tamaka, Kolar, Karnataka 563101 India.

A prospective longitudinal observational study was conducted on 24 patients of histopathologically confirmed squamous cell carcinoma of buccal mucosa upon whom bilateral 'middle meatal antrostomy was performed during the same sitting as the tumour resection with the main aim to assess the maxillary mucociliary clearance, pre-, during and post-irradiation; and compare the findings with the non-irradiated side in the same patient to avoid any confounding factors. All patients underwent methylene blue dye clearance and saccharine clearance tests before the commencement of radiation therapy, weekly during irradiation and again at first and sixth month of completion of irradiation. Pre-radiation there was statistically no difference ( > 0. Read More

BMJ Case Rep 2019 Nov 19;12(11). Epub 2019 Nov 19.

General Surgery, BYL Nair Charitable Hospital, Mumbai, India

Oral cancers rarely metastasize to the small intestines. In a previously operated case of squamous cell carcinoma of buccal mucosa without any known preoperative distant metastases, we report a case of solitary ileal perforation 3 months after the surgery. The edge of the ileal perforation was positive for squamous cell carcinoma on histopathology. Read More

Indian J Otolaryngol Head Neck Surg 2019 Oct 6;71(Suppl 1):410-416. Epub 2018 Apr 6.

3Department of Public Health, SRM Medical College Hospital and Research Centre, SRM University, Kattankulathur, Tamilnadu India.

Although there are various risk factors in the literature, the established primary risk factor for oral cancer is tobacco and betal-nut chewing habits. It is believed that pathogenesis of oral cancer depends on the aetiology. To assess the histopathological grade and Ki-67 expression in tobacco (smoking/smokeless) and non-tobacco (betal nut/pan masala) habitual buccal mucosa cancer. Read More

Int J Oral Maxillofac Surg 2020 May 16;49(5):558-563. Epub 2019 Nov 16.

Department of Oral and Craniomaxillofacial Surgery, Heidelberg University Hospital, Heidelberg, Germany; Department of Oral and Craniomaxillofacial Surgery, Saarland University Hospital, Homburg, Germany.

The aim of this study was to validate the prognostic significance of the lymph node ratio (LNR) in patients suffering from oral squamous cell carcinoma in regard to different anatomical subsites. A cohort of 430 patients was investigated to determine the rates of primary metastasis and local and regional disease recurrence. Correlation analysis of the LNR with relevant clinical and pathological parameters was performed. Read More

Clin Oral Investig 2019 Nov 9. Epub 2019 Nov 9.

Department of Medical Education and Research, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.

Objectives: Guanylate-binding protein 6 (GBP6) is a member of the guanylate-binding protein family, and its role in cancer has not yet been reported. We aimed to investigate the clinical significance of GBP6 in oral squamous cell carcinoma (OSCC).

Materials And Methods: Next-generation sequencing was applied for analyzing differential gene expression profiling between corresponding tumor adjacent normal (CTAN) and tumor tissue from two paired OSCC patients. Read More

World J Surg Oncol 2019 Nov 9;17(1):184. Epub 2019 Nov 9.

Department of Oral and Craniomaxillofacial Surgery, University Hospital Basel, Spitalstrasse 21, CH-4031, Basel, Switzerland.

Background: Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a rare self-limiting condition of the oral mucosa. The lesion manifests as an isolated ulcer that can be either asymptomatic or associated with mild to severe pain, and in most cases, it affects the tongue. TUGSE lesions may mimic malignancy such as squamous cell carcinoma, CD30 positive lymphoproliferative disorder, or infectious diseases such as primary syphilis, tuberculosis, or Epstein-Barr virus mucocutaneous ulcer. Read More

Int J Radiat Oncol Biol Phys 2020 02 25;106(2):320-328. Epub 2019 Oct 25.

Centre de Haute Energie, Nice, France.

Purpose: Oral mucositis (OM) is a frequent and painful sequela of concomitant chemoradiation (CRT) used for the treatment of head and neck cancer (HNC) for which there is no effective intervention. This randomized, placebo-controlled study evaluated the efficacy of a novel, mucoadhesive topical tablet formulation of clonidine in mitigating CRT-induced OM in patients with HNC.

Methods And Materials: Patients with HNC undergoing adjuvant radiation therapy (60-66 Gy; 5 × 1. Read More

Sci Rep 2019 Oct 30;9(1):15616. Epub 2019 Oct 30.

Laboratory Animal Center, Shanxi Key Laboratory of Experimental Animal Science and Human Disease Animal Model, Shanxi Medical University, Road Xinjian 56, Taiyuan, Shanxi, 030001, China.

MicroRNAs are known to play essential role in the gene expression regulation in cancer. In our research, next-generation sequencing technology was applied to explore the abnormal miRNA expression of oral squamous cell carcinoma (OSCC) in Chinese hamster. A total of 3 novel miRNAs (Novel-117, Novel-118, and Novel-135) and 11 known miRNAs (crg-miR-130b-3p, crg-miR-142-5p, crg-miR-21-3p, crg-miR-21-5p, crg-miR-542-3p, crg-miR-486-3p, crg-miR-499-5p, crg-miR-504, crg-miR-34c-5p, crg-miR-34b-5p and crg-miR-34c-3p) were identified. Read More

Gen Dent 2019 Nov-Dec;67(6):26-32

A 47-year-old man was referred for treatment of a painful lesion of 5 months' duration located on the left side of the maxilla. A small perforation in the buccal cortex was observed during the intraoral examination. Cone beam computed tomography (CBCT) showed an extensive, well-delimited radiolucent lesion extending from the alveolar ridge to the nasal cavity. Read More