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J Oral Implantol 2018 Dec 12. Epub 2018 Dec 12.

1 Kyushu Dental University Department of Oral Reconstruction and Rehabilitation Kyushu Dental University.

To perform safe implant treatment, the anatomical structure and bone quality at implant placement sites are evaluated based on a patient's CT data, but there is no definite method to determine placement sites and the appropriate number of implants. The objective of this study was to investigate the influence of the number and arrangement of implants on the stress distribution in 3-unit posterior fixed partial dentures for the posterior mandible by mechanical analysis using the finite element method. Three-dimensional finite element analysis models were constructed from the CT data of a patient with missing mandibular teeth (Nos. Read More

Methods Mol Biol 2019 ;1897:359-383

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Nucleic acid isolation is often the starting point for all downstream experiments in biomedical research. It is therefore the most crucial step in any molecular technique. DNA and RNA extraction follow protocols with standardized reagents, many of which are available in quality-controlled commercial kits. Read More

Methods Mol Biol 2019 ;1897:99-105

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Saliva and oral/buccal samples have become increasingly valuable sources of genetic material for clinical applications. The DNA obtained by these samples is of comparable quality to that from blood samples. This, coupled with the ease of collecting saliva and oral/buccal samples, has led to increased numbers of such samples being incorporated into biobanks. Read More

BMC Oral Health 2018 Dec 11;18(1):209. Epub 2018 Dec 11.

Department of preventive dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Free University Amsterdam, Gustav Mahlerlaan 3004, 1081, LA, Amsterdam, The Netherlands.

Background: A quantitative light-induced fluorescence digital (QLF-D) camera is able to assess demineralizations adjacent to orthodontic brackets. Rotations of teeth during and the presence of the orthodontic appliances may influence the longitudinal follow-up of such lesions over time.

Methods: Brackets were bonded on extracted teeth: 54 incisors and 31 canines. Read More

ORL J Otorhinolaryngol Relat Spec 2018 Dec 11;81(1):24-35. Epub 2018 Dec 11.

Maxillo-Facial Surgery Unit, Neurosensorial Department, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.

Objective: The buccal fat pad (BFP) has been progressively introduced into clinical practice for oral defect reconstruction. This study describes our experience with this technique and compares indications in the literature and outcomes.

Methods: We prospectively enrolled 24 patients presenting oral surgical defects and treated between January 2012 and January 2015 at our institution. Read More

J Prosthodont 2018 Dec 7. Epub 2018 Dec 7.

Division for Mutagenesis, Institute for Medical Research and Occupational Health, Zagreb, Croatia.

Purpose: This is a cross-sectional study to assess the incidence of micronuclei and other nuclear morphological changes in buccal epithelial cells of dental technicians.

Materials And Methods: The study was conducted on 45 dental technicians vs. 2 control groups: 50 dentists and 50 dental assistants. Read More

Oral Dis 2018 Dec 7. Epub 2018 Dec 7.

Department of Orthodontics, Institute of Craniofacial Deformity, College of Dentistry, Yonsei University, Seoul, Korea.

Objectives: To investigate the effect of local injection of receptor activator of nuclear factor kappa B ligand (RANKL) on experimental tooth movement and subsequent alveolar bone remodeling in mice.

Materials And Methods: Sixty mice were randomised to receive daily local RANKL or phosphate-buffered saline injections in the buccal premaxillary bone for 14 of 21 days of incisor movement, followed by a 21-day retention period. Five mice from each group were euthanised on days 0, 3, 7, 14, 21, and 42, and specimens were prepared for haematoxylin and eosin, tartrate-resistant acid phosphatase, and immunohistochemical staining. Read More

Head Neck 2018 Dec 11. Epub 2018 Dec 11.

MDS, Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.

Background: The objective was to study comprehensive mRNA expression profiles of buccal mucosa oral squamous cell carcinoma (OSCC-BM) and gingivo-buccal OSCC (OSCC-GB) in smokeless tobacco chewers to understand the biological behavior of OSCC at these specific sites and identify diagnostic and prognostic markers.

Methods: High throughput RNA sequencing transcriptome of fresh buccal mucosa (4 samples) and gingivo-buccal (4 samples) OSCC with normal oral mucosa (3 samples) was performed on Illumina NextSeq500 paired end sequencing with 75x2bp.

Results: In the comparison between OSCC and normal, there were 402 differentially expressed genes (DEGs); between OSCC-BM and normal, there were 467 DEGs; and between OSCC-GB and normal oral tissue, there were 608 DEGs. Read More

Curr Med Sci 2018 Dec 7;38(6):982-988. Epub 2018 Dec 7.

Department of Otolaryngology, Wuhan Hospital of Traditional Chinese and Western Medicine (Wuhan No. 1 Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

The precise anatomy of the facial nerve branches innervating rat whisker pad and the distribution of their corresponding motor neurons in facial nucleus area were investigated. The extratemporal facial nerves of 6 rats were anatomically observed under a surgical microscope, and then the nerve specimens of facial nerve branches at 7 anatomical sites were taken and examined for the axons and myelin sheath using Luxol fast blue staining. The distribution of facial motor neurons innervating the facial branches was observed in 12 rats by retrograde labelling. Read More

Drug Saf Case Rep 2018 Dec 10;6(1). Epub 2018 Dec 10.

Division of Psychiatry, Harare Central Hospital, PO Box ST 14, Southerton, Harare, Zimbabwe.

A 29-year-old Black female patient was admitted to a psychiatric ward with symptoms of major depressive disorder with psychosis. The patient was started on amitriptyline 50 mg/day and haloperidol 10 mg/day. On day 4 post-admission, the preferred first-line antidepressant, fluoxetine, became available and the patient was switched from amitriptyline to fluoxetine 20 mg/day. Read More

Biomed Res Int 2018 11;2018:5274754. Epub 2018 Nov 11.

Universidad de La Frontera, Dental School, Clinical Investigation and Dental Innovation Center (CIDIC), Temuco, Chile.

Background: Maintenance of hard tissue in the case of impacted third molars (M3M) with close relationship to the mandibular canal is still a surgical challenge which may be overcome using the inward fragmentation technique.

Methods: A consecutive case series of 12 patients required the extraction of 13 impacted M3M with a close relationship to the inferior alveolar nerve (IAN). Via occlusal miniflaps, M3M were exposed occlusal under endoscopic vision and removed by inward fragmentation. Read More

Plast Reconstr Surg Glob Open 2018 Oct 16;6(10):e1970. Epub 2018 Oct 16.

Long Island Plastic Surgical Group, PC, Garden City, New York, N.Y.

Background: Buccal fat pad excision is offered as a means of obtaining a more aesthetic midface. This procedure has been documented in the form of countless videos on Instagram and other social media platforms with no long-term patient follow-up. We performed a retrospective analysis of published data regarding buccal fat pad excision and sought to better elucidate pitfalls regarding this underreported procedure. Read More

Dent Res J (Isfahan) 2018 Nov-Dec;15(6):420-429

Department of Oral and Craniofacial Health Science, College of Dental Medicine, University of Sharjah, Sharjah, UAE.

Background: The aim of this study was to evaluate the stability of immediate implant placement for alveolar bone augmentation and preservation with bovine bone graft following atraumatic tooth extraction.

Materials And Methods: This was a prospective interventional study with convenient sampling ( = 10). Thirty patients aged between 18 and 40 years, who needed noncomplicated tooth extraction of mandibular premolar tooth, were sequentially divided equally into three groups. Read More

Int J Health Sci (Qassim) 2018 Nov-Dec;12(6):8-17

Department of Dental Public Health, Pediatric Dentistry and Orthodontics, Al Rass College of Dentistry, Qassim University, Kingdom of Saudi Arabia.

Objectives: The objective of our in vitro investigation was to assess the effect of a layer of three lining materials; flowable composite, flowable compomer, and light-curing glass ionomer cement as a liner on microleakage with Class V packable composite restorations in young premolar teeth.

Materials And Methods: A total of 40 premolars were assigned randomly into four groups of 10 teeth each (Groups 1, 2, 3, and 4). Class V cavities (3 mm × 2 mm × 1. Read More

Curr Genomics 2018 Dec;19(8):676-698

1Department of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM87131, USA; 2Department of Computer Science, University of New Mexico, Albuquerque, NM87131, USA.

Background: Adverse Childhood Experiences (ACEs), which include traumatic injury, are associated with poor health outcomes in later life, yet the biological mechanisms mediating this association are unknown. Neurocircuitry, immune system and hormone regulation differ from normal in adults reporting ACEs. These systems could be affected by epigenetic changes, including methylation of cytosine (5mC) in genomic DNA, activated by ACEs. Read More

PLoS One 2018 7;13(12):e0208364. Epub 2018 Dec 7.

Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.

Antimicrobial multidrug-resistant microorganisms (MDRO) can be transmitted between companion animals and their human owners. Aim of this study was to determine the prevalence of extended spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) and Staphylococcus aureus including methicillin-resistant S. aureus (MRSA) in different companion animal species. Read More

Stomatologija 2018 ;20(3):66-72

Clinic of Orthodontics, Faculty of Odontology, Lithuanian University of Health Sciences, J. Lukšos-Daumanto g. 6, LT-3009 Kaunas, Lithuania.

Objective: The aim of this systematic review was to evaluate and compare distalization effect in maxillary buccal segment between Palatal Skeletal Anchorage (PSA) and Zygoma Gear Appliance (ZGA) in evidence-based way.

Materials And Methods: Relevant studies published between January 2007 till December 2017 in PubMed, ScienceDirect, AJO-DO and Scopus electronic databases were identified. Inclusion criteria were: English language, study performed on humans, randomized or nonrandomized clinical trials, assessment of buccal segment distalization by Palatal or Zygomatic skeletal anchorage and patient's clinical preoperative and post-operative evaluation measured by cephalometric analysis. Read More

Neural Regen Res 2019 Jan;14(1):124-131

Department of Otolaryngology Head and Neck Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Olfactory ensheathing cells from the olfactory bulb and olfactory mucosa have been found to increase axonal sprouting and pathfinding and promote the recovery of vibrissae motor performance in facial nerve transection injured rats. However, it is not yet clear whether olfactory ensheathing cells promote the reparation of facial nerve defects in rats. In this study, a collagen sponge and silicone tube neural conduit was implanted into the 6-mm defect of the buccal branch of the facial nerve in adult rats. Read More

Colloids Surf B Biointerfaces 2018 Nov 29;175:166-174. Epub 2018 Nov 29.

Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, University Campus of Cartuja, 18071 Granada, Spain; Nanoscience and Nanotechnology Institute (IN2UB), University of Barcelona, 645 Diagonal Ave., 08028 Barcelona, Spain. Electronic address:

Clotrimazole (CLT) was formulated in a multiple W/O/W emulsion (ME) with the aim of evaluating its potential as topical anticandidal agent and comparing with marketed products. A previously evaluated CLT-ME was selected and physicochemically characterized. The in vitro release behavior and the ex vivo permeation profiles were assessed using Franz diffusion cells using three different types of biological membranes: human skin and porcine buccal, sublingual and vaginal mucosae. Read More

Forensic Sci Int 2018 Nov 26;294:140-149. Epub 2018 Nov 26.

National Institute of Forensic Science, Australia New Zealand Policing Advisory Agency, 637 Flinders Street, Docklands, 3008, Australia.

Rapid DNA technology has the ability to provide DNA analysis results in real-time. The purpose of this study was to assess the potential investigative value that could be gained by using a rapid DNA workflow in Australia, for reference DNA samples. A survey of police charging stations and DNA analysis laboratories in five Australian jurisdictions identified that a rapid DNA analysis workflow could have impacted the decision to release a person of interest from custody in 0. Read More

Parkinsonism Relat Disord 2018 Nov 28. Epub 2018 Nov 28.

Department of Neurology, Loma Linda University Medical Center, Loma Linda, CA, USA.

We propose the use of the term tardive dyskinesia to refer to the original description of repetitive and complex oral-buccal-lingual (OBL) movements and the analogous repetitive movements of the limbs, trunk, or pelvis. The term tardive syndrome is an umbrella term to be used to refer to the spectrum of all persistent hyperkinetic, hypokinetic, and sensory phenomenologies resulting from chronic dopamine receptor blocking agent (DRBA) exposure. TD is a type of TS. Read More

Mol Phylogenet Evol 2018 Dec 7. Epub 2018 Dec 7.

Landcare Research, Private Bag 92170, Auckland Mail Centre, Auckland 1142, New Zealand.

Benthimermithid nematodes are parasites of invertebrates currently classified within their own order. Relationships between the Benthimermithida and other nematode orders, however, remain unclear due to their relatively simple morphology, their rarity, and paucity of molecular sequence data. Here, we combine molecular sequences obtained from Trophomera cf. Read More

Pregnancy Hypertens 2018 Oct 19;14:15-22. Epub 2018 May 19.

Obstetrics and Gynaecology, Universite de Sherbrooke, Canada. Electronic address:

Objectives: As a follow-up to the CHIPS trial (Control of Hypertension In Pregnancy Study) of 'less tight' (versus 'tight') control of maternal blood pressure in pregnancy, CHIPS-Child investigated potential developmental programming of maternal blood pressure control in pregnancy, by examining measures of postnatal growth rate and hypothalamic-pituitary adrenal (HPA) axis activation.

Methods: CHIPS follow-up was extended to 12 ± 2 months corrected post-gestational age for anthropometry (weight, length, head/waist circumference). For eligible children with consent for a study visit, we collected biological samples (hair/buccal samples) to evaluate HPA axis function (hair cortisol levels) and epigenetic change (DNA methylation analysis of buccal cells). Read More

Int J Oral Maxillofac Implants 2018 Dec 5. Epub 2018 Dec 5.

Purpose: Scientific publications have recently found that bone graft quality and implant survival rates were not influenced by antrostomy membrane coverage during maxillary sinus floor augmentation with a lateral approach. The aim of this study was to evaluate the stability of the bone substitute after a maxillary sinus floor augmentation procedure with or without using a covering membrane.

Materials And Methods: This retrospective study evaluated all patients who were enrolled between April 2016 and January 2017. Read More

Clin Oral Implants Res 2018 Dec 6. Epub 2018 Dec 6.

Department of Oral Surgery and Implant Dentistry, Faculdade de Medicina Dentária da Universidade de Lisboa, Portugal.

Objectives: To evaluate the performance of two types of zirconia frameworks.

Material And Methods: From 2014 to 2016, in a prospective clinical trial 150 patients were rehabilitated with 83 and 110 implant-supported, screw-retained, full-arch ceramic-veneered zirconia (PVZ) rehabilitations and monolithic zirconia with porcelain veneering limited to buccal (MZ) rehabilitations, respectively. Patients were consecutively enlisted according to pre-defined inclusion criteria and evaluated on 4 months intervals. Read More

JBI Database System Rev Implement Rep 2018 Dec 3. Epub 2018 Dec 3.

The Institute of Health and Community, University of Plymouth and The University of Plymouth Centre for Innovations in Health and Social Care.

REVIEW QUESTION:: the questions of this review are. Read More

Analyst 2018 Dec 6. Epub 2018 Dec 6.

Departamento de Química, Universitat Politècnica de València, Camino de Vera s/n, E46022, Valencia, Spain. and Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM), Universitat Politècnica de València-Universitat de València, Valencia, Spain and Unidad Mixta UPV-La Fe, Nanomedicine and Sensors, IIS La Fe, Valencia, Spain.

The development of a high-performance assay readout using integrated detectors is a current challenge in the implementation of DNA tests in diagnostic laboratories, particularly for supporting pharmacogenetic tests. A method for allelic discrimination, associated with single nucleotide polymorphisms (SNPs), is presented. Genomic DNA is extracted from blood and buccal swab samples. Read More

Int J Nanomedicine 2018 9;13:7319-7331. Epub 2018 Nov 9.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China,

Background: Non-injectable delivery of peptides and proteins are not feasible due to its large molecular, high hydrophilic and gastrointestinal degradation. Therefore, proposing a new method to solve this problem is a burning issue.

Purpose: The objective of this study was to propose a novel protein delivery strategy to vanquish the poor efficacy of buccal mucosa delivery systems for protein delivery and then investigate the detailed mechanisms of the enhanced buccal delivery of protein, using insulin as a model drug. Read More

Nutrients 2018 Dec 4;10(12). Epub 2018 Dec 4.

Centre for Nutrition and Food Sciences, Queensland Alliance for Agriculture and Food Innovation, The University of Queensland, St. Lucia QLD 4072, Australia.

Eating behaviour in humans is a complex trait that involves sensory perception. Genetic variation in sensory systems is one of the factors influencing perception of foods. However, the extent that these genetic variations may determine food choices in a real meal scenario warrants further research. Read More

Clin Implant Dent Relat Res 2018 Dec 3. Epub 2018 Dec 3.

Section of Graduate Periodontology, University Complutense, Madrid, Spain.

Background: Collagen matrices used around immediate implants may reduce morbidity although there is limited evidence on their performance.

Purpose: To evaluate soft and hard tissue changes when combining immediate implants, hard and soft tissue grafting, and an immediate provisional restoration.

Material And Methods: In 12 patients, immediate implants were placed in the anterior maxillary and first premolar area together with a xenogeneic bone substitute. Read More

Medwave 2018 Nov 26;18(7):e7352. Epub 2018 Nov 26.

Servicio Maxilofacial, Hospital Clínico San Borja Arriarán, Santiago, Chile; Departamento de Cirugía y Traumatología Bucal y Maxilofacial, Facultad de Odontología, Universidad de Chile; Proyecto Epistemonikos, Santiago, Chile. Email: Address: Centro Evidencia UC, Pontificia Universidad Católica de Chile, Diagonal Paraguay 476, Santiago, Chile.

Introduction: Maxillofacial fractures are associated with significant morbidity, loss of function and aesthetic sequelae, among others. Within mandibular fractures, mandibular condylar fractures are the most frequent. These can be treated by surgical treatment or conservative treatment (orthopedic). Read More

Transl Androl Urol 2018 Dec;7(6):907-911

1Department of Urology, 2Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA.

Background: To evaluate the feasibility of use of rectal mucosal grafts for augmentation urethroplasty.

Methods: A series of five patients who underwent rectal mucosal graft urethroplasty for urethral stricture disease were identified. Descriptive statistics were used to describe these patients. Read More

Nat Methods 2018 Dec 30;15(12):1059-1066. Epub 2018 Nov 30.

CAS Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China.

An outstanding challenge of epigenome-wide association studies (EWASs) performed in complex tissues is the identification of the specific cell type(s) responsible for the observed differential DNA methylation. Here we present a statistical algorithm called CellDMC ( https://github.com/sjczheng/EpiDISH ), which can identify differentially methylated positions and the specific cell type(s) driving the differential methylation. Read More

J Oral Maxillofac Surg 2018 Nov 7. Epub 2018 Nov 7.

Associate Professor and Chair, Department of Oral and Maxillofacial Surgery, University of Michigan, Ann Arbor, MI.

Purpose: Buccal squamous cell carcinoma (BSCC) is rare in the United States. Given its location, few anatomic barriers to spread exist and it has been found to have a high locoregional recurrence rate. The role of elective neck dissection (END) in patients with clinically negative neck findings (N0) is not clear. Read More

Zoology (Jena) 2018 Oct 7;130:1-5. Epub 2018 Aug 7.

Okinawa Churaumi Aquarium, 424, Motobu, Okinawa, 905-0206, Japan.

For benthic fishes, breathing motion (e.g., oral, pharyngeal, and branchial movements) can result in detection by both prey and predators. Read More

Eur J Pharm Sci 2018 Nov 28;128:112-117. Epub 2018 Nov 28.

Drug Transport & Delivery Group, Department of Physics, Chemistry & Pharmacy, University of Southern Denmark, Odense, Denmark. Electronic address:

Development of buccal application forms is gaining increasing interest in recent years, mostly driven by the insight that enabling formulations may help to overcome limitations as well as the need for patient-oriented medicines. A key characteristic of dosage forms is whether they can grant absorption of therapeutically relevant doses across the limited absorption area in the mouth and realistic time window. Despite the generally accepted paradigm to replace or at least reduce animal experiments, current transport studies towards oromucosal drug delivery still are dominated by in vivo or ex vivo animal studies. Read More

Mar Drugs 2018 Nov 29;16(12). Epub 2018 Nov 29.

School of Life Sciences, Liaoning Normal University, Dalian 116081, China.

Cystatins are a family of cysteine protease inhibitors which are associated with a variety of physiological and pathological processes in vivo. In the present study, the cDNA sequence of a cystatin F homologue called Lm-cystatin F was cloned from the buccal glands of . Although Lm-cystatin F shares a lower homology with cystatin superfamily members, it is also composed of a signal peptide and three highly conserved motifs, including the G in the N-terminal, QXVXG, as well as the PW in the C-terminal of the sequence. Read More

Braz Dent J 2018 Nov-Dec;29(6):562-568

Department of Orthodontics, Universidade Positivo, Curitiba, PR, Brazil.

This study aimed to evaluate the effects of the Herbst appliance on the proclination and protrusion of the lower incisors, and to verify if the device causes alveolar bone loss in the anterior region of the mandible. This is a retrospective study. The sample consisted of 35 individuals. Read More

Oper Dent 2018 Oct 10. Epub 2018 Oct 10.

Objectives:: To investigate the survival and failure mode of fiber-post resin restorations over preparations with different ferrule designs when submitted to a fatigue load test.

Methods And Materials:: Fifty bovine incisors were selected and divided into five groups (n=10) according to ferrule design: a no-ferrule group, a 2-mm circumferential ferrule group, a 2-mm buccal ferrule group, a 2-mm lingual ferrule group, and a 2-mm buccal and lingual ferrule group. The fiberglass post was cemented and the composite core was built up and prepared, followed by cementation of a full composite crown. Read More

Georgian Med News 2018 Oct(283):97-103

David the Builder University of Georgian; Tbilisi State Medical University; Beritashvili Center of Experimental Biomedicine; Sachkhere District Hospital, Georgia.

The purpose of our study was to identify the nature of the cause-effect relationship between the risks of developing of Chronic Obstructive Pulmonary Disease (COPD) and Cardio-vascular Disease (CVD) in patients residing in the villages of Chiatura district, characterized by varying degrees of environmental stress. The residents (n=400) of the Chiatura district living in the villages, Khreiti, Perevisa and Rgani were examined. The villages are characterized by different degrees of ecological tension (the villages differ both in their remoteness from sources of environmental pollution - manganese mining quarries and the scale of its extraction, which allows them to rank according to the degree of environmental tension: Khreiti - low, Perevis - medium, Rgani - high). Read More

Angle Orthod 2018 Dec 5. Epub 2018 Dec 5.

Objective:: To evaluate stresses on maxillary teeth during alignment of a palatally impacted canine (PIC) under different loading conditions with forces applied in vertical and buccal directions.

Materials And Methods:: A three-dimensional finite element model of the maxilla was developed from a cone beam computed tomographic scan of a patient with a left PIC. Traction was simulated under different setups: (1) palatal spring extending from a transpalatal bar (TPB) anchored on the first molars (M1) and alternatively combined with different archwires (0. Read More

J Craniomaxillofac Surg 2018 Nov 15. Epub 2018 Nov 15.

Department of Oral and Maxillofacial Surgery (Head Dr. Jurjen Schortinghuis), Treant Hospital, Emmen-Stadskanaal, The Netherlands. Electronic address:

Purpose: The aim of this study was to describe the surgical technique of immediate dental implant placement in calvarial grafts for augmentation of the severely resorbed maxilla and to assess the treatment results.

Methods: In 13 patients the maxilla was augmented with calvarial bone followed by simultaneous dental implant placement (total: 68 implants). In the frontal "knife edge" region, implants were inserted in the buccal plated area. Read More

J Evid Based Dent Pract 2018 Dec 25;18(4):349-351. Epub 2018 Oct 25.

Article Title And Bibliographic Information: Adverse effects of lingual and buccal orthodontic techniques: A systematic review and meta-analysis. Ata-Ali F, Ata-Ali J, Ferrer-Molina M, Cobo T, De Carlos F, Cobo J. Am J Orthod Dentofacial Orthop 2016; 149:820-9. Read More

Pharmaceutics 2018 Dec 3;10(4). Epub 2018 Dec 3.

Graduate Program in Health Sciences, Federal University of Rio Grande do Norte (UFRN), Av. General Gustavo Cordeiro de Faria-SN-Petrópolis, Natal 59012-570, Brazil.

Oral candidiasis (OC) is an infectious disease caused by microorganisms of the genus , leading to lesions in the buccal cavity. Its treatment consists of the administration of topical or systemic antifungal agents, which may compromise the patient compliance due to its side effects, highlighting the need for alternative treatments. In this scenario, bullfrog oil, an animal oil composed of a pool of saturated and unsaturated fatty acids, is introduced as a potential antifungal raw material. Read More

J Oral Implantol 2018 Dec 4. Epub 2018 Dec 4.

1 Tufts University School of Medicine Periodontology Tufts University School o Dental Medicine.

The longevity of an immediate implant placement in a molar area with the flapless extraction technique has not yet been deeply investigated, and only a few studies have previously been published. This article describes a successful case of immediate implant placement with a follow-up evaluation after more than five years. An immediate implant was placed in a fresh socket after an atraumatic extraction with no flap elevation. Read More

Microsurgery 2018 Dec 4. Epub 2018 Dec 4.

Department of Plastic and Reconstructive Surgery, School of Medicine, Tokyo Women's Medical University, Tokyo, Japan.

The authors developed a one-stage double-muscle reconstruction technique for facial paralysis using a latissimus dorsi (LD) flap and a serratus anterior (SA) flap, which were dually reinnervated by the contralateral facial nerve (FN) and ipsilateral masseter nerve (MN). The procedure was performed for 61-year-old man 3-years after resection of a malignant tumor and a 24-year-old woman 10-years after temporal fracture with facial paralysis. A double-muscle flap comprising left LD and SA flaps was harvested, a 15-cm thoracodorsal nerve (TN) section was attached to the LD flap, and 5-cm and 1-cm sections of the long thoracic nerve (LTN) were attached to the proximal and distal sides of SA flap. Read More

Caspian J Intern Med 2018 ;9(4):325-327

Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

Background: Behcet's syndrome is a disease with different aspects in its clinical manifestations. The purpose of this study was to evaluate the simultaneous presence of oral mucosal and ophthalmologic lesions in patients with Behcet's syndrome.

Methods: From April 2012 to December 2014, 50 cases of Behcet's syndrome who referred to the Departments of Ophtalmology, Oral Diseases and Infectious Diseases of Babol University Medical Sciences were entered into the study. Read More

Transl Psychiatry 2018 Dec 3;8(1):266. Epub 2018 Dec 3.

MRC Integrative Epidemiology Unit at the University of Bristol, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Childhood adversity affects later health, but the underlying molecular mechanisms are unclear. Although there is some evidence from animal models and case-control studies of a role for DNA methylation, evidence from human population-based studies is limited. In two cohorts (mothers from the Avon Longitudinal Study of Parents and Children, ALSPAC, n = 780 and women from the MRC National Survey of Health and Development, NSHD, n = 552), we assessed the association of seven adverse childhood experiences (ACEs: parental physical illness, parental mental illness, parental death, parental separation, suboptimal maternal bonding, childhood illness and child maltreatment) as well as their combination (ACE score) with genome-wide DNA methylation levels measured using the Illumina Infinium HumanMethylation450 BeadChip in peripheral blood at mean age 47 years (ALSPAC) and in buccal cells at age 53 years (NSHD). Read More