The lack of BTK does not impair monocytes and polymorphonuclear cells functions in X-linked agammaglobulinemia under treatment with intravenous immunoglobulin replacement.
- Filomena Monica Cavaliere,
- Alessandro Prezzo,
- Caterina Bilotta,
- Metello Iacobini,
- Isabella Quinti
PLoS One 2017 19;12(4):e0175961. Epub 2017 Apr 19.
Department of Molecular Medicine, Sapienza University of Rome, Roma, Italy.
The lack of BTK in X-linked agammaglobulinemia (XLA) patients does not affect monocytes and polymorphonuclear cells (PMN) phenotype and functions. In this study, we show that XLA patients had an increased frequency of the intermediate monocytes subset and that BTK-deficient monocytes and PMN had a normal expression of receptors involved in the activation and cellular responses. We demonstrate that BTK is not required for migration, phagocytosis and the production of reactive oxygen species (ROS) following engagement of FC gamma receptors (FcγR). Read More