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Rev Bras Med Vet 2022 14;44:e003521. Epub 2022 Apr 14.

Veterinarian, DSc. Departamento de Zootecnia, Instituto Federal de Educação, Ciência e Tecnologia do Sertão Pernambucano (IF-Sertão). Petrolina Zona Rural, PE, Brazil.

The present study aimed to assess the prevalence and risk factors associated with bovine brucellosis in slaughterhouses in the state of Ceará using spatial distribution and flow network analysis. Four slaughterhouses were sampled in Ceará: two under municipal inspection and two under state inspection. Blood samples were randomly collected from bovine animals, resulting in a total of 964 samples. Read More

Vet Sci 2022 Jun 20;9(6). Epub 2022 Jun 20.

Coordinación de Investigación Institucional, Universidad México Americana del Norte, Ciudad Reynosa C.P. 88640, Tamaulipas, Mexico.

The milk ring test is a detection assay for antibodies against in bovine milk. It has good sensitivity but tends to give false positive results. In this study, we standardized the application of the fluorescence polarization assay (FPA) for the detection of antibodies against in goat milk. Read More

Emerg Infect Dis 2022 Jul;28(7):1460-1465

Serum agglutination test plus exposure history were used to diagnose most cases of human brucellosis in 2 China provinces. After appropriate treatment, 13.3% of acute brucellosis cases progressed to chronic disease; arthritis was an early predictor. Read More

Comput Math Methods Med 2022 29;2022:4617685. Epub 2022 May 29.

College of Mathematics and System Sciences, Xinjiang University, Urumqi 830046, China.

In this paper, we proposed a stochastic SVEI brucellosis model with stage structure by introducing the effect of environmental white noise on transmission dynamics of brucellosis. By Has'minskii theory and constructing suitable Lyapunov functions, we established sufficient conditions on the existence of ergodic stationary distribution for the considered model. Moreover, we also established sufficient condition for extinction of the disease. Read More

J Radiol Case Rep 2022 May 1;16(5):1-9. Epub 2022 May 1.

Department of Radiology, Advanced diagnostic and interventional radiology research center (ADIR), Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Neurobrucellosis is an uncommon serious complication of brucellosis. Diagnosis of neurobrucellosis could be difficult due to non-specific clinical and radiological findings. So, in endemic regions, neurobrucellosis should be included in the differential diagnosis list of patients with recent neurological disorders. Read More

New Microbiol 2022 04;45(2):115-123

Multi-Specialist Clinical Institute for Orthopaedic Trauma Care (COT), Messina, Italy

Infectious diseases still register significant morbidity and mortality worldwide. Surveillance through a mandatory notification system allows the continuous analysis of the situation even at a local level and its importance has been highlighted by the recent COVID-19 pandemic. This paper aimed to outline the importance of the mandatory notification system as a Public Health tool in the continuous monitoring of infectious diseases. Read More

BMC Vet Res 2022 Jun 13;18(1):224. Epub 2022 Jun 13.

Institute of Bacterial Infections and Zoonosis, Friedrich-Loeffler Institut, Naumburger Str. 96a, 07743, Jena, Germany.

Background: Brucella suis is a zoonotic pathogen with a serious impact on public health and the pig industry worldwide. Information regarding B. suis in pigs in Egypt is scarce. Read More

Comb Chem High Throughput Screen 2022 Jun 9. Epub 2022 Jun 9.

Department of Pharmacy, The Eighth Affiliated Hospital of Xinjiang Medical University, Urumqi 830013, Xinjiang, China.

Background and Objectives Qingbutongluo pill（QBTLP）, a Chinese herbal preparation, has been developed to treat brucellosis for many years with a good therapeutic effect. This study aimed to preliminarily explore its potential molecular mechanisms against brucellosis through network pharmacology. Methods The active ingredients of QBTLP were screened out mainly from Traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP), and their potential targets were predicted through PubChem database and Swiss Target Prediction platform. Read More

Med Trop Sante Int 2022 03 30;2(1). Epub 2022 Mar 30.

Faculté de médecine, Université Batna 2, Batna, Algérie.

Introduction: Brucellosis is a major zoonosis affecting livestock and transmitted to humans; it is widespread worldwide with 500,000 new cases per year according to the World Health Organization. It has become rare in countries that have established an eradication policy of the disease in animals and pasteurization of milk, but remains endemo-epidemic in Algeria, where it constitutes a public health problem (incidence of 24.41 per 100,000 inhabitants in 2017). Read More

Int J Mol Sci 2022 May 30;23(11). Epub 2022 May 30.

Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt.

Brucellae are Gram-negative, aerobic, non-motile coccobacilli causing brucellosis in man and animals. The disease is one of the most significant yet neglected global zoonoses. Especially in developing countries, brucellosis is causing public health problems and economic losses to private animal owners and national revenues. Read More

Curr Drug Saf 2022 Jun 8. Epub 2022 Jun 8.

Department of Pharmacology and Toxicology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.

Objective: The purpose of this study was to investigate renal function in patients with brucellosis before and at the end of gentamicin therapy. To ensure the safety of therapeutic doses of gentamicin, renal functions in brucellosis patients were monitored regarding drug serum levels and check for early detection biomarkers of nephrotoxicity.

Methods: In this cross-sectional study, 41 patients (25 men and 16 women, aged over 15 years), with confirmed acute brucellosis that referred to Brucellosis Research Center in Hamadan, west of Iran between March 2018 to February 2019. Read More

Clin Infect Dis 2022 Jun 8. Epub 2022 Jun 8.

Institute of Continuing Medical Education of Ioannina, Greece H. Trikoupi 10, 45333, Ioannina, Greece Tel: +30 2651028289.

An inadequacy in sanitizing processes in a biopharmaceutical plant in Lanzhou, China, during July and August 2019, led to the aerosolization of Brucella that was subsequently spread through wind in nearby settlements and academic institutes, resulting in more than 10,000 human brucellosis cases, as of November 2020. The leak, possibly the largest laboratory accident in the history of infectious diseases, underlines the particular characteristics of Brucella that have made the pathogen a historical entity in biodefense research and a major cause of laboratory-associated infections. It further underlines the need for enhanced vigilance and strict regulatory interventions in similar facilities. Read More

Foodborne Pathog Dis 2022 Jun 8. Epub 2022 Jun 8.

Departamento de Microbiología e Inmunología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Ciudad de México, México.

Brucellosis is a zoonotic infection caused by the consumption of contaminated raw milk and dairy products. This study aims to compare survival rates of RB51 and S19 vaccine strains to that of virulent 2308 strain during the manufacture of fresh and ripened cheeses. To do this, we inoculated fresh pasteurized milk with RB51, S19, or 2308 at a 6 × 10 colony-forming unit per milliliter concentration during the cheese making process. Read More

Rev Inst Med Trop Sao Paulo 2022 6;64:e38. Epub 2022 Jun 6.

Universidade Federal da Fronteira Sul , Campus Realeza, Realeza , Paraná , Brazil.

Brucellosis is one of the most important and widespread bacterial zoonotic diseases worldwide, and it is transmitted to humans from various sources, including direct contact with infected animals and the ingestion of contaminated products, including unpasteurized milk. There are only a few epidemiological studies on said disease in humans in Western Santa Catarina, a region instantiated by agriculture. Thus, the objective of this study was to characterize the epidemiological aspects of human brucellosis reported in Western Santa Catarina from 2013 to 2018. Read More

IDCases 2022 20;29:e01519. Epub 2022 May 20.

Dept of infectious disease, Kashan School of medicine, Kashan university of medical sciences, Kashan, Iran.

Brucellosis is a zoonotic disease endemic to the Middle East and Mediterranean basin. It has gained diagnostic challenge recently due to its increasingly non-specific and vague manifestations at presentation. Here, we report a 53-year-old man presenting with undulating fever and shaking chills and frequency, dysuria, hesitancy and malodorous urine. Read More

Eur J Med Res 2022 Jun 3;27(1):84. Epub 2022 Jun 3.

Department of Physiology, College of Medicine, University of Sulaimani, Sulaimani New, Street 29, Zone 207, Sulaymaniyah, 46001, Republic of Iraq.

Background: During the last 2 years, in the Kurdistan Region, Northern Iraq, there were thousands of COVID-19 cases that have not been reported officially, but diagnosed and confirmed by private laboratories and private hospitals, or clinicians based on typical clinical signs, as well as few people using home self-test after appearing of some flu-like clinical symptoms. Thus, this study aims to assess the misdiagnosis and mismanagement of cases before COVID-19 confirmation.

Methods: This study enrolled 100 consecutive patients who visited an outpatient clinic of Shar Hospital that had symptoms highly suspicious of COVID-19 infection while misdiagnosed previously to have other types of disease. Read More

Infect Dis Poverty 2022 Jun 4;11(1):63. Epub 2022 Jun 4.

Baotou Municipal Center for Disease Control and Prevention, Baotou, Inner Mongolia, China.

Background: Brucellosis poses a serious threat to human and animal health, particularly in developing countries such as China. The Inner Mongolia Autonomous Region is one of the most severely brucellosis-endemic provinces in China. Currently, the host immune responses functioning to control Brucella infection and development remain poorly understood. Read More

J Infect Dev Ctries 2022 May 30;16(5):807-812. Epub 2022 May 30.

University of Health Sciences, Gulhane Faculty of Medicine, Department of Medical Microbiology, Ankara, Turkey.

Introduction: Clinical presentation of brucellosis is variable. Therefore, it must be confirmed with laboratory findings. Standard tube agglutination test (STAT) is commonly used for diagnosis of brucellosis. Read More

Clin Infect Dis 2022 Jun 2. Epub 2022 Jun 2.

Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands.

A patient was diagnosed with B. canis following exposure to infected dogs in her breeding facility. Transboundary spread of B. Read More

Front Vet Sci 2022 12;9:887671. Epub 2022 May 12.

Instituto de Patobiología Veterinaria, Instituto Nacional de Tecnología Agropecuaria (INTA)-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), N. Repetto y de Los Reseros, Buenos Aires, Argentina.

and are the primary etiological agents of brucellosis in small domestic ruminants. was first isolated in 1887 by David Bruce in Malta Island from spleens of four soldiers, while was originally isolated in Australia and New Zealand in early 1950's from ovine abortion and rams epididymitis. Today, both agents are distributed worldwide: remains endemic and associated with an extensive negative impact on the productivity of flocks in -some regions, and is still present in most sheep-raising regions in the world. Read More

Front Chem 2022 11;10:890252. Epub 2022 May 11.

Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Brucellosis is a systemic disease in both acute and chronic forms which can affect any organ or tissue in the body. One of the biggest issues in treating this disease is its relapse. In this study, a complete treatment of brucellosis was evaluated using enhanced performance of doxycycline and hydroxychloroquine drugs by using solid lipid nanoparticles (SLN) conjugated cadmium-telluride quantum dots. Read More

Front Genet 2022 13;13:872660. Epub 2022 May 13.

Department of Veterinary Medicine, School of Veterinary and Animal Science, Federal University of Goiás, Goiânia, Brazil.

Curraleiro Pé-Duro (CPD) cattle, a Brazilian local breed, are animals that are highly resistant to infectious and parasitic diseases. Strategies for the conservation of the breed and the genetic resistance to diseases should also consider the characteristics of the breed. The objective of this study was to analyze the diversity and population structure of the CPD breed using microsatellite markers and to correlate the serological profiles for causative agents of brucellosis, leptospirosis, neosporosis, leukosis, infectious bovine rhinotracheitis, and bovine viral diarrhea. Read More

Int J Infect Dis 2022 May 28;122:276-278. Epub 2022 May 28.

Infectious Diseases Unit, Raymond Poincaré Teaching Hospital, AP-HP, Versailles Saint-Quentin University, Garches, France; UMR 1173, Université Paris Saclay, Montigny le Bretonneux, France. Electronic address:

We report the case of a 58-year-old immunocompetent man from Algeria, who presented to the hospital with fever and hepatic cytolysis. Abdominal computed tomography scan showed a homogeneous splenomegaly and a hypodense 12-mm mass on the posterior wall of the esophagus. After ruling out tuberculosis, the patient was diagnosed with brucellosis. Read More

Microorganisms 2022 Apr 30;10(5). Epub 2022 Apr 30.

Institute for Tropical Health and Department of Microbiology and Parasitology, Medical School, University of Navarra and IdISNA, 31008 Pamplona, Spain.

Brucellosis is a major zoonotic disease caused by species. Historically, the disease received over fifty names until it was recognized as a single entity, illustrating its protean manifestations and intricacies, traits that generated conundrums that have remained or re-emerged since they were first described. Here, we examine confusions concerning the clinical picture, serological diagnosis, and incidence of human brucellosis. Read More

BMC Vet Res 2022 May 27;18(1):202. Epub 2022 May 27.

Department of Microbiology and Infectious Diseases, Aristotle University of Thessaloniki, 54124, Thessaloniki, Greece.

Background: Brucellosis still remains an endemic disease for both livestock and human in Greece, influencing the primary sector and national economy in general. Although farm animals and particularly ruminants constitute the natural hosts of the disease, transmission to humans is not uncommon, thus representing a serious occupational disease as well. Under this prism, knowledge concerning Brucella species distribution in ruminants is considered a high priority. Read More

Microb Pathog 2022 Jul 24;168:105557. Epub 2022 May 24.

College of Animal Science and Technology, Shihezi University, Shihezi, 832003, Xinjiang Provence, China. Electronic address:

ArsR-family transcriptional factors regulates diverse physiological functions necessary for Brucella adaptation to environmental changes. However, whether the ArsR-family transcriptional regulator are related to virulence, and the precise determination of ArsR direct targets in Brucella are still unknown. Therefore, we created a 2308ΔArsR6 mutant of B. Read More

Trop Med Infect Dis 2022 May 18;7(5). Epub 2022 May 18.

Maihdol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.

A national animal disease surveillance network initiated by the Lao PDR government is adopted and reinforced by a joint research project between the National Animal Health Laboratory (NAHL), the Department of Livestock and Fisheries (DLF), and the Mahidol Oxford Tropical Medicine Research Unit (MORU). The network is strengthened by staff training and practical exercises and is utilised to provide zoonotic or high-impact disease information on a national scale. Between January and December 2020, large ruminant samples are collected monthly from 18 abattoirs, one in each province, by provincial and district agriculture and forestry officers. Read More

Epidemiol Health 2022 May 18:e2022048. Epub 2022 May 18.

Departement of Preventive Medicine and Epidemiology, Faculty of Medicine, Tunis, Tunisia.

Objectives: The incidence of Human brucellosis in Tunisia in 2017 was 9.8 per 100,000 population. In Douz district two cases were reported in March, 2018. Read More

Aust Vet J 2022 May 23. Epub 2022 May 23.

School of Veterinary and Animal Science, Charles Sturt University, Wagga Wagga, New South Wales, Australia.

Brucellosis is a zoonotic disease with worldwide distribution. Brucella suis serotype 1 is thought to be maintained in the Australian feral pig population, with disease prevalence higher in Queensland (Qld) than New South Wales (NSW). Pig hunting is a popular recreational activity in rural Qld and NSW, with feral pigs in these states thought to carry B. Read More

Math Biosci Eng 2022 Apr;19(6):6396-6414

School of Mathematics, Taiyuan University of Technology, Taiyuan 030024, China.

Brucellosis is a zoonotic disease caused by Brucella, and it is an important infectious disease all over the world. The prevalence of brucellosis in the Chinese mainland has some spatial characteristics besides the temporal trend in recent years. Due to the large-scale breeding of sheep and the frequent transportation of sheep in various regions, brucellosis spreads wantonly in pastoral areas, and human brucellosis spreads from traditional pastoral areas and semi-pastoral areas in the north to non-pastoral areas with low incidence in the south. Read More