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Vet Med Sci 2019 Apr 23. Epub 2019 Apr 23.

Infectious Diseases Division, Department of Medicine & Department of Research, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, College of Medicine, Alfaisal University, Riyadh, Kingdom of Saudi Arabia.

At completion of Hajj, the Islamic pilgrimage to Makkah, pilgrims give thanks for the blessing, and acceptance, of Hajj, marking the end of the pilgrimage by sacrificing an animal and distributing the sacrificial meat to the poor. With over two million Muslims making Hajj, each Hajj, more than 1.2 million heads of cattle: sheep, goats and camels are slaughtered. Read More

Trop Med Infect Dis 2019 Apr 22;4(2). Epub 2019 Apr 22.

Public Health Foundation India, Gurgaon 122002, India.

Brucellosis is endemic among dairy animals in India, contributing to production losses and posing a health risk to people, especially farmers and others in close contact with dairy animals or their products. Growing urban populations demand increased milk supplies, resulting in intensifying dairy production at the peri-urban fringe. Peri-urban dairying is under-studied but has implications for disease transmission, both positive and negative. Read More

Arch Razi Inst 2019 Mar 1;74(1):1-6. Epub 2019 Mar 1.

Department of Animal Science, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran.

Brucella bacterium causes Brucellosis, an infectious disease spreading from animals to human. Brucella lumazine synthase (BLS) is a highly immunogenic protein with adjuvant properties, which has been introduced as an effective protein carrier for vaccine development. This protein also plays a significant role in inducing immune system. Read More

J Spinal Cord Med 2019 Apr 23:1-6. Epub 2019 Apr 23.

d Service de Radiologie , Institut Mohamed Kassab d'orthopédie , Ksar Said , Tunis , Tunisie.

Objective: To report a series of Granulomatous Spondylodiscitis (GS) with focus on the histopathological features of the different forms of GS.

Design: Case series.

Setting: Pathology department of Charles Nicolle's Hospital of Tunisia Participants: This study included 57 patients diagnosed with GS. Read More

J Wildl Dis 2019 Apr 22. Epub 2019 Apr 22.

2   Department of Biomedical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA.

Brucellosis, caused by , has been eliminated from livestock in the US. Remaining wildlife reservoirs are the bison () and elk () populations in Yellowstone National Park and the surrounding area, from which there is periodic exposure and transmission to surrounding livestock herds. Elk account for nearly all of the livestock exposure, and the infection appears to be expanding in the elk population. Read More

Emerg Infect Dis 2019 May;25(5):1021-1023

We report a case of hepatic brucelloma in France. This diagnosis may be suspected in any patient who has a liver abscess after traveling to a brucellosis-endemic area. Brucella spp. Read More

Pathogens 2019 04 16;8(2). Epub 2019 Apr 16.

Infectious Diseases and Anti-Infective Therapy Research Group, Sharjah Medical Research Institute and College of Pharmacy, University of Sharjah, Sharjah 27272, UAE.

Zoonoses present a major public health threat and are estimated to account for a substantial part of the infectious disease burden in low-income countries. The severity of zoonotic diseases is compounded by factors such as poverty, living in close contact with livestock and wildlife, immunosuppression as well as coinfection with other diseases. The interconnections between humans, animals and the environment are essential to understand the spread and subsequent containment of zoonoses. Read More

Rev Soc Bras Med Trop 2019 Apr 11;52:e20180243. Epub 2019 Apr 11.

Department of Orthopedics, Beijing Ditan Hospital, Capital Medical University, Beijing, China.

Brucellosis, a zoonosis with worldwide distribution, is a systemic infection caused by bacteria of the genus Brucella. Meanwhile, brucellosis often causes complications, such as osteoarticular involvement, and spondylitis is the most prevalent and important clinical form. Here, is a case of cervical brucellar spondylitis causing incomplete limb paralysis in a middle-aged male. Read More

J Ethnopharmacol 2019 Apr 13:111872. Epub 2019 Apr 13.

Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; Department of Pharmacognosy and Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address:

Ethnopharmacological Relevance: Chronic periodontitis is an inflammatory process of the oral cavity that is caused by different reasons. Streptococcus mutans bacteria is the main cause of the disease. Scrophularia striata in Iranian traditional medicine is used to heal inflammation of gum and mouth. Read More

Eur J Clin Microbiol Infect Dis 2019 Apr 15. Epub 2019 Apr 15.

Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.

Brucellosis in pregnant women is reported to be associated with obstetric complications (OCs), and adequate data for human brucellosis during pregnancy are largely lacking. We performed this multicenter retrospective cross-sectional study to evaluate the epidemiology, clinical course, treatment responses, and outcomes of brucellosis among pregnant women. The study period comprised a 14-year period from January 2002 to December 2015. Read More

Antimicrob Resist Infect Control 2019 3;8:62. Epub 2019 Apr 3.

1Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Shahid fahmideh street, Park Mardome, Hamadan, IR Iran.

Background: Brucellosis is a zoonotic disease caused by species. It has been estimated that more than 500,000 new cases of Brucellosis occur annually all around the world. Relapse of the disease is one of the most important challenges. Read More

Clin Nucl Med 2019 Apr 12. Epub 2019 Apr 12.

A 17-year-old adolescent boy's known case of classical seminoma stage IB for which he underwent right radical orchiectomy. At the first-year follow-up, CT abdomen and pelvis was performed and showed lytic vertebral lesion with left paravertebral necrotic mass that warranted further investigation to exclude disease recurrence. FDG PET/CT scan was performed to evaluate the extent of disease and showed high uptake in the same areas. Read More

Front Cell Infect Microbiol 2019 28;9:78. Epub 2019 Mar 28.

Key Laboratory of Major Diseases in Children, Ministry of Education, National Key Discipline of Pediatrics (Capital Medial University), National Clinical Research Center for Respiratory Diseases, Beijing Key Laboratory of Pediatric Respiratory Infection Disease, Beijing Pediatric Research Institute, Beijing Children's Hospital, Capital Medical University, Beijing, China.

.is capable of causing disease in a range of animal hosts, and human brucellosis is regarded as a life-threating disease. A novel isothermal amplification technique, termed multiple cross displacement amplification (MCDA), was employed for detecting all species strains. Read More

J Int Med Res 2019 Apr 10:300060519838921. Epub 2019 Apr 10.

1 Children's Medical Centre, Hunan Provincial People's Hospital/The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China.

Although extremely rare, congenital brucellosis can occur via perinatal transmission. We report a case of an infant born prematurely at 34-36 weeks' gestation who had pyrexia, shortness of breath, hepatosplenomegaly and thrombocytopenia. Blood cultures were positive for Gram-negative coccobacilli and Brucella infection was suspected. Read More

Rev Sci Tech 2018 Dec;37(3):805-821

Bovine brucellosis is a major zoonosis and is responsible for significant reproductive disorders and production losses in cattle. Surveillance and control are regulated at the European level with specific conditions to obtain and maintain the officially free status, which facilitates access to export markets. These European standards allow for harmonisation in brucellosis surveillance and diagnosis while leaving some flexibility to countries in the choice of measures to meet the desired objectives. Read More

Vet Clin North Am Small Anim Pract 2019 Apr 5. Epub 2019 Apr 5.

Department of Epidemiology, College of Public Health, University of Iowa, 145 North Riverside Drive, Iowa City, IA 52242, USA; Center for Emerging Infectious Diseases, University of Iowa Research Park, Coralville, IA 52241, USA. Electronic address:

The genus Brucella is a primary cause of reproductive diseases. Widely known as a problem in livestock, Brucella is gaining notoriety as a cause of canine reproductive disease and as a scourge to dog breeders. Only within the last few decades has the risk of severe brucellosis in dogs, and the people who own and work with them, been more fully appreciated. Read More

Comp Immunol Microbiol Infect Dis 2019 Apr 19;63:87-93. Epub 2019 Jan 19.

Department of Molecular Biology, Pasteur Institute of Iran, Pasteur Ave., Tehran, 13164, Iran. Electronic address:

Background: Brucellosis is the most common zoonotic diseases worldwide. The aim of this study was to develop and evaluate the diagnostic performance of an indirect-ELISA (I-ELISA) method based on whole cell Brucella abortus S99 lysates for detection of IgM anti-Brucella antibodies in a human serum.

Materials And Methods: The study was conducted in two species-rich endemic areas of Iran (Tehran and Lorestan provinces). Read More

Vet Med Sci 2019 Apr 8. Epub 2019 Apr 8.

School of Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia.

A cross-sectional study was conducted to estimate the seroprevalence of bovine brucellosis in smallholder farms in seven regions in Pakistan, identify herd and individual level risk factors for seropositivity and assess the level of engagement of farmers with risk factors. In total, 1063 cattle and buffalo belonging to 420 herds in seven districts were sampled. The Rose Bengal test (RBT), indirect enzyme-linked immunosorbent assay (I-ELISA) and competitive enzyme-linked immunosorbent assay (C-ELISA) were used for the serological diagnosis of bovine brucellosis on all the serum samples. Read More

New Microbiol 2019 Jan;42(1):43-48

Department of Human Pathology of Adult and Developmental Age "Gaetano Barresi", University of Messina, Italy.

Brucellosis is one of the most common zoonoses in the world, especially in Southern Italy, where many cases are still recorded every year. 128 cases of brucellosis were observed in Messina (Sicily) in 2016, representing a tenfold increase in the number of cases of brucellosis expected. The aim of this multicenter retrospective study was to analyze clinical and microbiological aspects of a brucellosis outbreak in the province of Messina in 2016, the incidence of its complications and the treatment combinations applied. Read More

BMC Pregnancy Childbirth 2019 Apr 5;19(1):118. Epub 2019 Apr 5.

Department of Pathology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.

Background: Pregnant women infected with brucellosis have been shown to have higher odds of having been exposed to goats and raw goat products and adverse pregnancy outcomes. However, information on these associations in asymptomatic pregnant women is limited, particularly in the brucellosis-endemic areas. This study aimed to assess the association of a history of exposure to goats and/or raw goat products and the serological status of anti-Brucella abortus immunoglobulin G (IgG) with adverse pregnancy outcomes among pregnant women, and explore factors associated with having exposure to goats and/or raw goat products. Read More

Gastroenterol Hepatol Bed Bench 2019 ;12(1):52-59

Department of Microbiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Aim: This study determined the genes encoding the binding and receiving factors of iron and microbial biofilm in strains isolated from mucosal samples of patients with colorectal cancer and inflammation of the colorectal compared to healthy people.

Background: Colorectal cancer is one of the most important malignancies in recent years. is the most important infectious agents associated with colorectal cancer that has numerous virulence factors such as iron uptake and adhesion factors included in the process of inflammation and colorectal cancer. Read More

Indian J Pediatr 2019 Apr 3. Epub 2019 Apr 3.

Department of Pediatric Critical Care, Tata Medical Centre, Kolkata, India.

J Bacteriol 2019 Apr 1. Epub 2019 Apr 1.

Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, USA.

The Gram-negative cell envelope is a remarkable structure with core components that include an inner membrane, an outer membrane, and a peptidoglycan layer in the periplasmic space between. Multiple molecular systems function to maintain integrity of this essential barrier between the interior of the cell and its surrounding environment. We show that a conserved DUF1849-family protein, EipB, is secreted to the periplasmic space of , a monophyletic group of intracellular pathogens. Read More

Infect Immun 2019 Apr 1. Epub 2019 Apr 1.

Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USA.

Osteoarticular brucellosis is the most common complication in -infected humans regardless of age, sex, or immune status. The mechanism of bone destruction caused by species remained partially unknown due to the lack of a suitable animal model. Here, to study this complication, we explored the suitability of the use of the NOD- mouse to study osteoarticular brucellosis and examined the potential use of this strain to evaluate the safety of live attenuated vaccine candidates. Read More

FEBS J 2019 Mar 30. Epub 2019 Mar 30.

Fundación Instituto Leloir, IIBBA-CONICET, Buenos Aires, Argentina.

Brucella spp. are pathogenic intracellular Gram-negative bacteria adapted to life within cells of several mammals, including humans. These bacteria are the causative agent of brucellosis, one of the zoonotic infections with the highest incidence in the world and for which a human vaccine is still unavailable. Read More

PLoS Negl Trop Dis 2019 03 25;13(3):e0007285. Epub 2019 Mar 25.

China Animal Health and Epidemiology Center, Qingdao, Shandong Province, China.

Background: Brucellosis is one of the most common zoonoses worldwide, causing direct losses to the livestock industry and threatening human health. Little is known about the status and factors affecting farmers' private investment in the prevention and control of sheep brucellosis in China.

Methodology/principal Findings: From April to October 2017, a cross-sectional, house-based study was conducted in 7 Chinese provinces. Read More

PLoS One 2019 22;14(3):e0213689. Epub 2019 Mar 22.

National and OIE Reference Laboratory for Brucellosis, Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise 'G. Caporale,' Campo Boario, Teramo, Italy.

Brucellosis is a major public health problem still prevalent as a neglected endemic zoonosis requiring proactive attention in many communities worldwide. The present study involved analysis of Brucella field strains submitted for typing to the Italian National Reference Laboratory for Brucellosis from 2007 to 2015. Strains were identified at the species and biovar levels by classic and molecular techniques according to the World Organisation for Animal Health Manual. Read More

J Appl Microbiol 2019 Mar 21. Epub 2019 Mar 21.

Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India, 576104.

Aims: In this present study, the utility of a newly developed Loop mediated isothermal amplification (LAMP) and real-time PCR assays designed to amplify the virB gene region of B. melitensis were evaluated from human clinical specimens.

Methods And Results: 54 culture confirmed cases of brucellosis and 54 culture negative but clinically suspected cases of brucellosis were included in the study. Read More

Trop Doct 2019 Mar 21:49475519836359. Epub 2019 Mar 21.

2 Senior Demonstrator, Department of Microbiology, Sardar Patel Medical College, Bikaner, Rajasthan, India.

Zoonoses such as Brucella, Mycobacterium bovis, Campylobacter, Salmonella, Escherichia coli, Listeria, etc. are spread by ingestion of contaminated unpasteurised milk products (from infected cattle) and result in infectious outbreaks, hospitalisations and mortality. In Southeast Asian countries, raw goat's milk is sometimes used for dengue infection-associated thrombocytopenia; however, evidence to support this sociocultural practice is lacking. Read More

J Immunol 2019 May 20;202(9):2671-2681. Epub 2019 Mar 20.

Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte 30270-901, Brazil;

is a facultative intracellular bacterium that causes brucellosis, a prevalent zoonosis that leads to abortion and infertility in cattle, and undulant fever, debilitating arthritis, endocarditis, and meningitis in humans. Signaling pathways triggered by involves stimulator of IFN genes (STING), which leads to production of type I IFNs. In this study, we evaluated the pathway linking the unfolded protein response (UPR) and the endoplasmic reticulum-resident transmembrane molecule STING, during infection. Read More

Iran J Neurol 2018 Jul;17(3):152-153

Department of Infectious Diseases, Vali-e-Asr Hospital, Zanjan University of Medical Sciences, Zanjan, Iran.

Vet Immunol Immunopathol 2019 Mar 2;209:70-77. Epub 2019 Mar 2.

Laboratorio de Inmunología, Departamento de Sanidad Animal y Medicina Preventiva (SAMP), Centro de Investigación Veterinaria Tandil (CIVETAN-CONICET-CICPBA), Facultad de Ciencias Veterinarias (FCV), Universidad Nacional del Centro de la Provincia de Buenos Aires (UNCPBA), Tandil, 7000, Buenos Aires, Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina. Electronic address:

Subcellular vaccines against ovine contagious epididymitis due Brucella ovis can solve some shortcomings associated with the use of Brucella melitensis Rev 1. We have demonstrated that the parenteral immunization with polymeric antigen BLSOmp31 emulsified in oil adjuvant conferred significant protection against B. ovis in rams. Read More

Vet Immunol Immunopathol 2019 Mar 14;209:31-36. Epub 2019 Feb 14.

College of Veterinary Medicine, Chonbuk National University, Iksan Campus, 54596, Iksan, Republic of Korea. Electronic address:

We demonstrated the use of attenuated Salmonella strains secreting Brucella antigens SodC, Omp19, BLS, and PrpA as live vaccine candidates against Brucella abortus infection and presented their cross-protection against Salmonella infections using a BALB/c mice model. Here, a single immunization with each individual strain was capable of establishing significantly high (p < 0.05) Brucella-specific systemic immunoglobulin (Ig)G and secretory IgA (sIgA) responses compared to control mice. Read More

BMC Vet Res 2019 Mar 18;15(1):95. Epub 2019 Mar 18.

Department of Health Management, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada.

Background: No comprehensive studies have been carried out on the infectious causes of abortion in Kenyan dairy cattle herds. A survey was carried out to determine the seroprevalence of antibodies against Bovine Viral Diarrhoea Virus (BVDV), Brucella abortus (BA) and Neospora caninum (NC) among dairy cattle herds in Nakuru County, a major dairying area in Kenya. A prospective sero-epidemiological study was also undertaken to investigate the effects of BVDV, BA and NC on the occurrence of bovine abortion in dairy cattle herds, where monthly rectal palpations for pregnancy were performed, and monthly serum samples were tested for antibodies to the 3 pathogens. Read More

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Mar;40(3):350-353

Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China; Engineering Technology Research Center of Inner Mongolia Autonomous Region, Tongliao 028000, China.

To understand the epidemiological characteristics of brucellosis in Hainan province. Automatic microbial identification system of Vitek 2 compact was used for the preliminary identification of 16 brucellosis cases in Hainan province from 2012 to 2017, and further confirmation was performed with traditional biological typing methods. The epidemiological and clinical characteristics of the patients were analyzed in combination with the results of serological and etiological tests for raised livestock. Read More

Case Rep Med 2019 10;2019:3701016. Epub 2019 Feb 10.

Internal Medicine Department, University Hospital of Patras, Rio, Greece.

Brucellosis remains an important public health problem with endemic characteristics in many countries. Brucellosis can affect almost all organs and systems of human body. Cardiac complications are unusual, occurring in less than 2% of patients and usually manifest as endocarditis. Read More

Pak J Med Sci 2019 Jan-Feb;35(1):129-135

Dr. Mohamudha Parveen Rahamathulla, PhD. Department of Medical Lab Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Wadi Al Dawaser-11991, Kingdom of Saudi Arabia.

Background And Objective: Brucellosis is an important zoonotic disease and a major public health problem in the Middle East countries including Saudi Arabia. This study has evaluated the seroprevalence of human brucellosis in Wadi Al Dawaser region of Central Saudi Arabia.

Methods: The study was conducted for three years (2015-2018) at Wadi Al Dawaser general hospital. Read More

BMC Res Notes 2019 Mar 12;12(1):130. Epub 2019 Mar 12.

Department of Microbiology, School of Medicine, University of Hamadan, Hamadan, Iran.

Objective: Methicillin-resistant Staphylococcus aureus cause to a variety of hard to cure infections. MRSA isolates also, produce an arsenal of virulence factors contribute to severe infections. The aim of this study was to find out the relationship between agr locus and presence of S. Read More

BMC Infect Dis 2019 Mar 11;19(1):240. Epub 2019 Mar 11.

Clinical laboratory department of Guangdong Women and Children's hospital, Xiaoping Mu, No.521 Xingnan Road, Panyu, 511400, Guagnzhou, China.

Background: Brucella is high-consequence pathogen and one of the most common seen laboratory- acquired infection pathogens. Quick and accurate detection of the pathogen will be of great important to reducing laboratory- acquired infection. Traditional biomedical reaction based method is time consumption, and mass spectrometry based method greatly reduces time consumption in pathogen identification. Read More

Epidemiol Infect 2019 Jan;147:e73

Sydney School of Veterinary Science, The University of Sydney,425 Werombi Road, Camden, 2570 NSW,Australia.

We evaluated the performance of three serological tests - an immunoglobulin G indirect enzyme linked immunosorbent assay (iELISA), a Rose Bengal test and a slow agglutination test (SAT) - for the diagnosis of bovine brucellosis in Bangladesh. Cattle sera (n = 1360) sourced from Mymensingh district (MD) and a Government owned dairy farm (GF) were tested in parallel. We used a Bayesian latent class model that adjusted for the conditional dependence among the three tests and assumed constant diagnostic accuracy of the three tests in both populations. Read More

Analyst 2019 Apr;144(8):2704-2715

School of Public Health of Jilin University, Changchun, Jilin 130021, P. R. China.

Members of the Brucella spp. are facultative intracellular bacteria that can cause global brucellosis, a zoonotic disease. Herein, a novel fluorescence signal amplification (FSA) method for the rapid detection of B. Read More

Microbiol Resour Announc 2019 Mar 7;8(10). Epub 2019 Mar 7.

National Reference Laboratory for Animal Brucellosis, China Institute of Veterinary Drug Control, Beijing, China.

Avian polyomavirus can infect multiple bird species and cause inflammatory disease with high mortality in young psittacine birds. In this study, we sequenced and analyzed an avian polyomavirus isolated from a pigeon in China, strain APV-P, which is closely related to a polyomavirus in psittacine birds. Read More

PLoS One 2019 11;14(3):e0213587. Epub 2019 Mar 11.

Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, United States of America.

Brucella abortus RB51 is an attenuated, stable, spontaneous rough mutant derived in the laboratory from the virulent strain B. abortus 2308. Previous studies discovered that the wboA gene, which encodes a glycosyltransferase required for synthesis of the O-polysaccharide, is disrupted in strain RB51 by an IS711 element. Read More

Microbiol Immunol 2019 Mar 9. Epub 2019 Mar 9.

Brucellosis Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

IL-17is one of the most important inflammatory cytokines that stimulate immunity responses in humans infected with Brucella species, acting as a regulator that reduces release of γ-IFN, thus increasing resistance to brucellosis. Gene polymorphisms in the regulatory regions of cytokine-encoding genes affect the amountsof cytokines produced and play a fundamental role in infectious diseases. The aim of this study was to determine the association between IL-17 gene polymorphisms and susceptibility to brucellosis. Read More

Microbiol Spectr 2019 03;7(2)

Paul G. Allen School for Global Animal Health, Washington State University, Pullman, WA 99164.

Bacteria of the genus colonize a wide variety of mammalian hosts, in which their infectious cycle and ability to cause disease predominantly rely on an intracellular lifestyle within phagocytes. Upon entry into host cells, organisms undergo a complex, multistage intracellular cycle in which they sequentially traffic through, and exploit functions of, the endocytic, secretory, and autophagic compartments via type IV secretion system (T4SS)-mediated delivery of bacterial effectors. These effectors modulate an array of host functions and machineries to first promote conversion of the initial endosome-like -containing vacuole (eBCV) into a replication-permissive organelle derived from the host endoplasmic reticulum (rBCV) and then to an autophagy-related vacuole (aBCV) that mediates bacterial egress. Read More

Infect Disord Drug Targets 2019 Mar 7. Epub 2019 Mar 7.

Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran. Iran.

Background: Brucellosis, a major health problem in developing countries, is a multisystem infection with a broad spectrum of clinical manifestations. Hematological complications, ranging from an intravascular coagulopathy to mild homeostasis disorders (such as gammopathy), have been reported in brucella infection. These signs and symptoms may lead to misdiagnosis of brucellosis with other hematological diseases. Read More

Iran J Public Health 2019 Jan;48(1):132-138

Department of Molecular Diagnostics, Noor Pathobiology Laboratory, Tehran, Iran.

Background: Brucellosis as a zoonotic disease is widespread among human and animal that it continues to be a major public health problem. Due to the shortage of recent epidemiologic data regarding the brucellosis distribution in Iran, we convinced to evaluate the prevalence of brucellosis in provinces of Iran.

Methods: In this descriptive study, data were collected from brucellosis suspected patients referred to Noor Pathobiology Laboratory, Tehran, Iran from 18 out of 31 provinces of Iran during 2013-2015. Read More

BMC Vet Res 2019 Mar 7;15(1):81. Epub 2019 Mar 7.

Animal Medicine and Health Department, Faculty of Veterinary Medicine, Campus of The Autonomous University of Barcelona (UAB), 08193 Bellaterra, Barcelona, Spain.

Background: Bovine brucellosis is a zoonotic disease that causes substantial economic losses and has a strong impact on public health. The main objective of this paper is to determine the risk factors for new infections of Brucella abortus on Colombian cattle farms previously certified as being free of brucellosis. A case-control study was conducted by comparing 98 cases (farms certified as brucellosis-free for three or more years but became infected) with 93 controls (farms that remained brucellosis-free during at least the previous three years). Read More

Chemotherapy 2019 Mar 7;63(6):321-323. Epub 2019 Mar 7.

Department of Infectious Diseases and Clinical Microbiology, Sakarya University Faculty of Medicine, Sakarya, Turkey.

Drugs that have a good intracellular passage are used in the treatment of brucellosis. According to our knowledge, there is no report in English about rifabutin usage in brucellosis. We present a case that developed intolerance to many anti-brucella drugs, who was then successfully treated with a combination of rifabutin, ofloxacin, and ceftriaxone. Read More

JMIR Public Health Surveill 2019 Mar 7;5(1):e11382. Epub 2019 Mar 7.

Iraq Ministry of Health, Baghdad, Iraq.

Public health professionals in the Eastern Mediterranean region (EMR) have limited access to continuing education, including workshops and conferences in public health. Held under the theme Innovative Approaches: Adapting to the Current EMR Context, the Eastern Mediterranean Public Health Network (EMPHNET) organized and conducted the Sixth EMPHNET Regional Conference from March 26 to 29, 2018. This paper summarizes the key activities including workshops, roundtable discussions, oral and poster presentations, keynote speeches, and side meetings. Read More