48,706 results match your criteria Brown Syndrome


Familial chylomicronemia syndrome: A rare but devastating autosomal recessive disorder characterized by refractory hypertriglyceridemia and recurrent pancreatitis.

Trends Cardiovasc Med 2019 Mar 19. Epub 2019 Mar 19.

Division of Cardiology, Advocate Heart Institute at Advocate Lutheran General, Hospital, 1775 Dempster St., Parkside B-01, Park Ridge, IL 60068, USA. Electronic address:

Familial Chylomicronemia Syndrome (FCS) is a rare autosomal recessive lipid disorder characterized by severe hypertriglyceridemia and recurrent pancreatitis. Because the disorder is often misdiagnosed or not diagnosed and because traditional triglyceride lowering medications are often ineffective, the disease leads to a tremendous physical, social and emotional burden on afflicted patients and their caretakers. Mutations in 5 different genes have been implicated in the development of FCS, all of which have an effect on the activity of lipoprotein lipase. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S10501738193003
Publisher Site
http://dx.doi.org/10.1016/j.tcm.2019.03.001DOI Listing
March 2019
1 Read

Dopamine receptor D (DRD) polymorphisms with reduced functional potency intensify atrophy in syndrome-specific sites of frontotemporal dementia.

Neuroimage Clin 2019 Apr 10;23:101822. Epub 2019 Apr 10.

Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, CA, USA.

Objective: We aimed to understand the impact of dopamine receptor D (DRD) polymorphisms on neurodegeneration in patients with dementia. We hypothesized that DRDdampened-variants with reduced functional potency would be associated with greater atrophy in regions with higher receptor density. Given that DRD is concentrated in anterior regions of the limbic and cortical forebrain we anticipated genotype effects in patients with a more rostral pattern of neurodegeneration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nicl.2019.101822DOI Listing

Evaluation of Demodex mite viability using motility and scattered light intensity.

Exp Appl Acarol 2019 Apr 19. Epub 2019 Apr 19.

Charles Institute of Dermatology, University College Dublin, Dublin, Ireland.

Demodex mites have been suggested to have a role in various cutaneous and ocular disorders pathogenesis, such as rosacea or blepharitis. Evaluation of potential treatments with anti-Demodex effects is difficult because the viability of living mites needs to be evaluated during their exposure to the agent being tested. Mite viability is currently based solely on their observed movement. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10493-019-00358-4DOI Listing

Free-breathing 3-D quantification of infant body composition and hepatic fat using a stack-of-radial magnetic resonance imaging technique.

Pediatr Radiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Radiological Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Ste. B119, Los Angeles, CA, 90095, USA.

Background: Body composition and hepatic fat correlate with future risk for metabolic syndrome. In children, many conventional techniques for quantifying body composition and hepatic fat have limitations. MRI is a noninvasive research tool to study body composition and hepatic fat in infants; however, conventional Cartesian MRI is sensitive to motion, particularly in the abdomen because of respiration. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00247-019-04384-7
Publisher Site
http://dx.doi.org/10.1007/s00247-019-04384-7DOI Listing
April 2019
1 Read

The discovery of three new hare lagoviruses reveals unexplored viral diversity in this genus.

Virus Evol 2019 Jan 9;5(1):vez005. Epub 2019 Apr 9.

Marie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.

Our knowledge of mammalian viruses has been strongly skewed toward those that cause disease in humans and animals. However, recent metagenomic studies indicate that most apparently healthy organisms carry viruses, and that these seemingly benign viruses may comprise the bulk of virus diversity. The bias toward studying viruses associated with overt disease is apparent in the lagoviruses (family that infect rabbits and hares: although most attention has been directed toward the highly pathogenic members of this genus-rabbit haemorrhagic disease virus and European brown hare syndrome virus-a number of benign lagoviruses have also been identified. Read More

View Article

Download full-text PDF

Source
https://academic.oup.com/ve/article/doi/10.1093/ve/vez005/54
Publisher Site
http://dx.doi.org/10.1093/ve/vez005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456799PMC
January 2019
1 Read

Brown adipocytes and β3 stimulant-induced brown-like adipocytes contribute to prevention of renal crystal formation.

Am J Physiol Renal Physiol 2019 Apr 17. Epub 2019 Apr 17.

Department of Nephro-Urology, Nagoya, Japan.

According to recent studies, kidney stones are associated with metabolic syndrome. We focused on brown adipocytes and β3 stimulant-induced brown-like adipocytes to investigate how these adipocytes influence kidney stone disease. For the interscapular brown adipose tissue (iBAT) removal experiment, mice were subjected to either iBAT removal or sham operation (X-BAT group or Sham group), and after 3 weeks, renal crystal deposition was induced by intra-abdominal injection of glyoxylate (GOX) for 6 days. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/ajprenal.00523.2018DOI Listing
April 2019
1 Read

Design, synthesis and pre-clinical characterization of selective Factor D inhibitors targeting the alternative complement pathway.

J Med Chem 2019 Apr 17. Epub 2019 Apr 17.

Complement Factor D (FD), a highly specific S1 serine protease, plays a central role in the amplification of the alternative complement pathway (AP) of the innate immune system. Dysregulation of AP activity predisposes individuals to diverse disorders such as age-related macular degeneration (AMD), atypical hemolytic uremic syndrome (aHUS), membranoproliferative glomerulonephritis type II (MPGNII) and paroxysmal nocturnal hemoglobinuria (PNH). Previously, we have reported the screening efforts and identification of reversible benzylamine-based FD inhibitors (1 and 2) binding to the open active conformation of FD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jmedchem.9b00271DOI Listing

Siah2 modulates sex-dependent metabolic and inflammatory responses in adipose tissue to a high-fat diet challenge.

Biol Sex Differ 2019 Apr 15;10(1):19. Epub 2019 Apr 15.

Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.

Background: The obesity-related risk of developing metabolic syndrome is higher in males than in females of reproductive age, likely due to estrogen-mediated reduced adipose tissue inflammation and fibrosis with hypertrophied adipocytes. Depletion of the ubiquitin ligase Siah2 reduced white adipose tissue inflammation and improved glucose metabolism in obese male mice. Siah2 is a transcriptional target of estrogen, but data is lacking about the effect of Siah2 on adipose tissue of females. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13293-019-0233-yDOI Listing
April 2019
1 Read

Brown bowel syndrome: a rare malnutrition-related complication of bariatric surgery.

Nutr Hosp 2019 Apr 15. Epub 2019 Apr 15.

Department of Surgery. Faculty of Medical Sciences. Universidade Estadual de Campinas (UNICAMP).

Case Report: we present the case of a 44-year-old male who presented with uncontrollable diarrhea, severe protein-calorie malnutrition and multiple vitamin deficiencies, along with peripheral neuropathy ten years after classic biliopancreatic diversion (BPD). He underwent nutritional support and had the surgery converted to a Roux-en-Y gastric bypass, with an uneventful outcome. The histopathology of the resected bowel revealed lipofuscinosis of the muscular layer compatible with brown bowel syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.20960/nh.2257DOI Listing
April 2019
1 Read

Risk of cardiac arrhythmias in patients with chronic hepatitis B and C infections - A 13-year nationwide population-based study.

J Cardiol 2019 Apr 11. Epub 2019 Apr 11.

Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Chiayi, Taiwan.

Background: Chronic hepatitis C virus (HCV) infection is associated with higher risk of cardiovascular events than chronic hepatitis B virus (HBV). We aimed to investigate whether there is higher risk of arrhythmia in HCV infection.

Methods: Electronic medical records from National Health Institute Research Database during 2000-2012 were retrieved for patients with HBV or HCV. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jjcc.2019.03.009DOI Listing
April 2019
2 Reads

Bi-allelic Loss-of-Function CACNA1B Mutations in Progressive Epilepsy-Dyskinesia.

Am J Hum Genet 2019 Apr 10. Epub 2019 Apr 10.

Molecular Neurosciences, Developmental Neurosciences, UCL Great Ormond Street Institute of Child Health, London WC1N 1EH, UK; Department of Neurology, Great Ormond Street Hospital, London WC1N 3JH, UK. Electronic address:

The occurrence of non-epileptic hyperkinetic movements in the context of developmental epileptic encephalopathies is an increasingly recognized phenomenon. Identification of causative mutations provides an important insight into common pathogenic mechanisms that cause both seizures and abnormal motor control. We report bi-allelic loss-of-function CACNA1B variants in six children from three unrelated families whose affected members present with a complex and progressive neurological syndrome. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00029297193010
Publisher Site
http://dx.doi.org/10.1016/j.ajhg.2019.03.005DOI Listing
April 2019
6 Reads

Obsessive-compulsive symptoms in patients with schizophrenia: Relationships with olanzapine pharmacological parameters, psychopathology, and quality of life.

Psychiatry Res 2019 Mar 6;276:1-5. Epub 2019 Mar 6.

Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry, Wan-Fang Hospital, Taipei Medical University, No. 111, Sec. 3, Hsin-Long Rd, Taipei 116, Taiwan; Psychiatric Research Center, Wan-Fang Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address:

Obsessive-compulsive symptoms (OCS) occur in a substantial portion of schizophrenia patients and have significant impacts on clinical course. This study was intended to investigate the relationships of OCS with pharmacological parameters of olanzapine, psychopathology, and quality of life. Totally 151 schizophrenia patients were recruited, and rated using Yale-Brown Obsessive-Compulsive scale (YBOCS), Positive and Negative Syndrome Scale (PANSS), Montgomery-Åsberg Depression Rating Scale (MADRS), and World Health Organization Questionnaire on Quality of Life: Short Form (WHOQOL-BREF). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.psychres.2019.03.007DOI Listing

Early impairments in the retina of rats fed with high fructose/high fat diet are associated with glucose metabolism deregulation but not dyslipidaemia.

Sci Rep 2019 Apr 12;9(1):5997. Epub 2019 Apr 12.

Eye and Nutrition Research Group, Centre des Sciences du Goût et de l'Alimentation, AgroSup Dijon, INRA, CNRS, Université Bourgogne Franche-Comté, Dijon, France.

Way of life changes such as high consumption of processed foods rich in fat and sugar and sedentary lifestyle are associated with the increasing prevalence of metabolic syndrome (MetS) that affects about 35% in the American population. MetS is the main risk factor for diabetes mellitus, which is associated with vascular changes in the retina. However, the early consequences of MetS in the retina are not well described. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-42528-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461688PMC
April 2019
1 Read

Non-specific chest pain and subsequent serious cardiovascular readmissions.

Int J Cardiol 2019 Apr 2. Epub 2019 Apr 2.

Keele Cardiovascular Research Group, Keele University, Stoke-on-Trent, UK; Royal Stoke University Hospital, Stoke-on-Trent, UK. Electronic address:

Background: The rates of readmission for serious cardiovascular events among patients admitted with a diagnosis of non-specific chest pain are unknown.

Methods: A national retrospective cohort study in the United States was undertaken to evaluate the rates, trends and predictors of readmission for serious cardiovascular events (acute coronary syndrome (ACS), pulmonary embolism (PE) and aortic dissection (AD)) after an inpatient episode with a primary diagnosis of non-specific chest pain.

Results: Among 1,172,430 patients with an index diagnosis of non-specific chest pain between 2010 and 2014, 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcard.2019.04.001DOI Listing
April 2019
2 Reads

Deciphering White Adipose Tissue Heterogeneity.

Biology (Basel) 2019 Apr 11;8(2). Epub 2019 Apr 11.

Department of Biomedical Sciences, Heritage College of Osteopathic Medicine, Ohio University, Athens, OH 45701, USA.

Adipose tissue not only stores energy, but also controls metabolism through secretion of hormones, cytokines, proteins, and microRNAs that affect the function of cells and tissues throughout the body. Adipose tissue is organized into discrete depots throughout the body, and these depots are differentially associated with insulin resistance and increased risk of metabolic disease. In addition to energy-dissipating brown and beige adipocytes, recent lineage tracing studies have demonstrated that individual adipose depots are composed of white adipocytes that are derived from distinct precursor populations, giving rise to distinct subpopulations of energy-storing white adipocytes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/biology8020023DOI Listing
April 2019
3 Reads

Detection of circulating extracellular mRNAs by modified small-RNA-sequencing analysis.

JCI Insight 2019 Apr 11;5. Epub 2019 Apr 11.

Extracellular mRNAs (ex-mRNAs) potentially supersede extracellular miRNAs (ex-miRNAs) and other RNA classes as biomarkers. We performed conventional small-RNA-sequencing (sRNA-seq) and sRNA-seq with T4 polynucleotide kinase (PNK) end-treatment of total exRNA isolated from serum and platelet-poor EDTA, ACD, and heparin plasma to study the effect on ex-mRNA capture. Compared to conventional sRNA-seq PNK-treatment increased the detection of informative ex-mRNAs reads up to 50-fold. Read More

View Article

Download full-text PDF

Source
http://insight.jci.org/articles/view/127317
Publisher Site
http://dx.doi.org/10.1172/jci.insight.127317DOI Listing
April 2019
6 Reads

Helical side chain chemistry of a peptoid-based SP-C analogue: Balancing structural rigidity and biomimicry.

Biopolymers 2019 Apr 10:e23277. Epub 2019 Apr 10.

Department of Bioengineering, Stanford University, Stanford, California.

Surfactant protein C (SP-C) is an important constituent of lung surfactant (LS) and, along with SP-B, is included in exogenous surfactant replacement therapies for treating respiratory distress syndrome (RDS). SP-C's biophysical activity depends upon the presence of a rigid C-terminal helix, of which the secondary structure is more crucial to functionality than precise side-chain chemistry. SP-C is highly sequence-conserved, suggesting that the β-branched, aliphatic side chains of the helix are also important. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bip.23277DOI Listing

Acute ethanol produces ataxia and induces Fmr1 expression via histone modifications in the rat cerebellum.

Alcohol Clin Exp Res 2019 Apr 10. Epub 2019 Apr 10.

Center for Alcohol Research in Epigenetics, Department of Psychiatry.

Background: The cerebellum is fundamental for motor coordination and therefore crucial in ethanol-induced ataxia. Ethanol contributes to cerebellar pathophysiology. Fragile-X Mental Retardation protein (FMRP) is a complex regulator of RNA and synaptic plasticity implicated in Fragile-X Tremor and Ataxia Syndrome, a phenotype featuring increased Fmr1 mRNA expression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/acer.14044DOI Listing
April 2019
2 Reads

Economic Impact of the 2015 MERS Outbreak on the Republic of Korea's Tourism-Related Industries.

Health Secur 2019 Apr 10. Epub 2019 Apr 10.

Clive M. Brown, MD, is Branch Chief, Quarantine and Border Health Services, Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, Atlanta, Georgia.

The 2015 Middle East respiratory syndrome (MERS) outbreak in the Republic of Korea (ROK) is an example of an infectious disease outbreak initiated by international travelers to a high-income country. This study was conducted to determine the economic impact of the MERS outbreak on the tourism and travel-related service sectors, including accommodation, food and beverage, and transportation, in the ROK. We projected monthly numbers of noncitizen arrivals and indices of services for 3 travel-related service sectors during and after the MERS outbreak (June 2015 to June 2016) using seasonal autoregressive integrated moving average models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/hs.2018.0115DOI Listing
April 2019
7 Reads

Differentiating SGBS adipocytes respond to PPARγ stimulation, irisin and BMP7 by functional browning and beige characteristics.

Sci Rep 2019 Apr 9;9(1):5823. Epub 2019 Apr 9.

Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Brown and beige adipocytes are enriched in mitochondria with uncoupling protein-1 (UCP1) to generate heat instead of ATP contributing to healthy energy balance. There are few human cellular models to reveal regulatory networks in adipocyte browning and key targets for enhancing thermogenesis in obesity. The Simpson-Golabi-Behmel syndrome (SGBS) preadipocyte line has been a useful tool to study human adipocyte biology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-42256-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456729PMC
April 2019
1 Read

Systemic Lupus Erythematosus and Pregnancy: A Brief Review.

J Obstet Gynaecol India 2019 Apr 12;69(2):104-109. Epub 2019 Mar 12.

The Department of Obstetrics and Gynecology, Nowrosjee Wadia Maternity Hospital, Mumbai, India.

Systemic lupus erythematosus is a chronic multisystemic autoimmune disease that predominantly affects young women of childbearing age group. There is a complex immunologic interplay during pregnancy in patients with systemic lupus erythematosus. The pregnancy has direct impact on the disease where an increased rate of flares is noted, and lupus leads to increased risk of hypertensive diseases of pregnancy, preterm birth as well as miscarriages, particularly those with antiphospholipid antibodies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13224-019-01212-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430271PMC
April 2019
2 Reads

Detection of Seoul virus in wild brown rats () from pig farms in Northern England.

Vet Rec 2019 Apr 5. Epub 2019 Apr 5.

HPRU EZI, Institute of Infection and Global Health (IGH), University of Liverpool School of Life Sciences, Neston, Cheshire, UK.

Introduction: Hantaviruses are maintained by mammalian hosts, such as rodents, and are shed in their excretions. Clinical disease can occur in humans from spillover infection. Brown rats ( are the globally distributed reservoir host of Seoul virus (SEOV). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/vr.105249DOI Listing
April 2019
1 Read

The role of cardiolipin concentration and acyl chain composition on mitochondrial inner membrane molecular organization and function.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Apr 2;1864(7):1039-1052. Epub 2019 Apr 2.

Department of Nutrition, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

Cardiolipin (CL) is a key phospholipid of the mitochondria. A loss of CL content and remodeling of CL's acyl chains is observed in several pathologies. Strong shifts in CL concentration and acyl chain composition would presumably disrupt mitochondrial inner membrane biophysical organization. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bbalip.2019.03.012DOI Listing
April 2019
2 Reads

Acute neurological syndrome complicating secondary hyperparathyroidism.

Proc (Bayl Univ Med Cent) 2018 Oct 24;31(4):534-536. Epub 2018 Sep 24.

Division of Nephrology, Department of Internal Medicine, Baylor University Medical CenterDallasTexas.

Longstanding severe hyperparathyroidism can lead to the formation of "brown tumors," benign but locally aggressive neoplasms. We present the case of a young woman with end-stage renal disease on hemodialysis with uncontrolled secondary hyperparathyroidism. The patient presented with progressive lower extremity weakness and back pain. Read More

View Article

Download full-text PDF

Source
https://www.tandfonline.com/doi/full/10.1080/08998280.2018.1
Publisher Site
http://dx.doi.org/10.1080/08998280.2018.1499004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413995PMC
October 2018
3 Reads

Immunosuppressive therapy for pediatric aplastic anemia: a North American Pediatric Aplastic Anemia Consortium study.

Haematologica 2019 Apr 4. Epub 2019 Apr 4.

Dana Farber/Boston Children's Cancer and Blood Disorders Center, Boston MA

Quality of response to immunosuppressive therapy and long-term outcomes for pediatric severe aplastic anemia remain incompletely characterized. Contemporary evidence to inform treatment of relapsed or refractory severe aplastic anemia are also limited for pediatric patients. The clinical features and outcomes for 314 children treated from 2002-2014 with immunosuppressive therapy for acquired severe aplastic anemia were analyzed retrospectively from 25 institutions in the North American Pediatric Aplastic Anemia Consortium. Read More

View Article

Download full-text PDF

Source
http://www.haematologica.org/lookup/doi/10.3324/haematol.201
Publisher Site
http://dx.doi.org/10.3324/haematol.2018.206540DOI Listing
April 2019
13 Reads

Impostor Syndrome and Medicine: Talented people believing 'I am a fraud'.

R I Med J (2013) 2019 Apr 1;102(3):7-8. Epub 2019 Apr 1.

Clinical Professor of Medical Science at Brown University; co-editor-in-chief, Rhode Island Medical Journal.

View Article

Download full-text PDF

Source
April 2019
1 Read

Benralizumab for -Negative Hypereosinophilic Syndrome.

N Engl J Med 2019 04;380(14):1336-1346

From the Laboratory of Parasitic Diseases (F.L.K., F.L., M.M., J.W., L.W., T.B., T.M., B.P., P.Y., P.K., A.D.K.) and Biostatistics Research Branch (M.P.F.), National Institute of Allergy and Infectious Diseases, the Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (H.A., S.K.), and the Laboratory of Pathology, National Cancer Institute (A.P., M.Q.), National Institutes of Health (NIH), and the Departments of Laboratory Medicine (J.H.E., X.S., I.M.) and Transfusion Medicine (S.R.P.), NIH Clinical Center, Bethesda, Washington Adventist Hospital, Takoma Park (T.M.), and MedImmune (N.L., R.K.) and AstraZeneca (P.N., M.G.), Gaithersburg - all in Maryland; the Department of Veteran Affairs, Tennessee Valley Healthcare System, Chattanooga (J.H.E.); and MedImmune, South San Francisco, CA (L.Y.).

Background: Hypereosinophilic syndrome is a group of diseases defined by marked eosinophilia in blood or tissue and eosinophil-related clinical manifestations. Benralizumab is a monoclonal antibody against interleukin-5 receptor α, which is expressed on human eosinophils.

Methods: In this randomized, double-blind, placebo-controlled, phase 2 trial, we administered a series of three monthly subcutaneous injections of either benralizumab (at a dose of 30 mg) or placebo in 20 symptomatic patients who had -negative hypereosinophilic syndrome and an absolute eosinophil count of at least 1000 cells per cubic millimeter; all the patients were receiving stable therapy (drugs or dietary changes) for this disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1056/NEJMoa1812185DOI Listing
April 2019
6 Reads
55.873 Impact Factor

Methods for type I interferon detection and their relevance for clinical utility and improved understanding of rheumatic diseases.

Clin Exp Rheumatol 2019 Mar 25. Epub 2019 Mar 25.

Department of Paediatrics, Division of Rheumatology, The University of British Columbia, and BC Children's Hospital Research Institute, Vancouver, Canada.

Type I interferons (IFN) are a class of inducible and protective cytokines best known for immune defence against viruses and intracellular bacteria. Inappropriate stimulation or defective negative regulation of type I IFN expression however can lead to persistent type I IFN activity with detrimental effects. This is particularly relevant for a class of monogenic autoinflammatory diseases ("type I interferonopathies"), along with many other complex rheumatic diseases such as systemic lupus erythematosus (SLE), dermatomyositis (DM), systemic sclerosis (SSc), rheumatoid arthritis (RA) and Sjögren's syndrome (SS). Read More

View Article

Download full-text PDF

Source
March 2019
7 Reads

Streptococcus pneumoniae - An Uncommon but Noteworthy Cause of Intrauterine Fetal Demise and Acute Necrotizing Funisitis.

Fetal Pediatr Pathol 2019 Apr 3:1-7. Epub 2019 Apr 3.

b Warren Alpert Medical School of Brown University , Providence , RI , USA.

Background: Streptococcus pneumoniae (S. pneumoniae) is an uncommon cause of amniotic fluid infection and intrauterine fetal demise.

Case Report: A 39-year-old G8P2052 presented with preterm premature rupture of membrane at 22 weeks gestation and had a spontaneous vaginal delivery of a neonate who soon expired. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15513815.2019.1587121DOI Listing
April 2019
1 Read

Thrombolysis for atlantoaxial dislocation mimicking acute ischemic stroke: Case report and review.

Am J Emerg Med 2019 Mar 27. Epub 2019 Mar 27.

Stroke Center and Department of Neurology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Taiwan; School of Medicine, Tzu Chi University, Hualien, Taiwan. Electronic address:

The frequency of stroke mimics among stroke patients has been reported to be up to 30%, and that in patients who receive thrombolytic therapy ranges between 1% and 16%. Atlantoaxial dislocation with myelopathy mimicking stroke is extremely rare. An 83-year-old man with a history of old cerebellar infarction presented to the emergency department with acute left hemiplegia after a chiropractic manipulation of the neck and back several hours before symptom onset. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ajem.2019.03.044DOI Listing
March 2019
2 Reads

Postpartum hormones oxytocin and prolactin cause pro-arrhythmic prolongation of cardiac repolarization in long QT syndrome type 2.

Europace 2019 Apr 1. Epub 2019 Apr 1.

Department of Cardiology and Angiology I, Heart Center University of Freiburg, Hugstetter Str. 55, Freiburg, Germany.

Aims: Women with long QT syndrome 2 (LQT2) have a particularly high postpartal risk for lethal arrhythmias. We aimed at investigating whether oxytocin and prolactin contribute to this risk by affecting repolarization.

Methods And Results: In female transgenic LQT2 rabbits (HERG-G628S, loss of IKr), hormone effects on QT/action potential duration (APD) were assessed (0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/europace/euz037DOI Listing
April 2019
2 Reads

Riboflavin Treatment in Genetically Proven Brown-Vialetto-Van Laere Syndrome.

J Pediatr Neurosci 2018 Oct-Dec;13(4):471-473

Department of Pediatric Neurosciences, Bai Jerbai Wadia Hospital for Children, Acharya Donde Marg, Parel, Mumbai, Maharashtra, India.

Brown-Vialetto-Van Laere (BVVL) syndrome is a rare motor neuron disorder of childhood, which forms a continuous spectrum with Fazio-Londe syndrome. It is an autosomal-recessive inherited disease caused by mutations in intestinal riboflavin transporter genes. We describe a child with genetically proven BVVL syndrome where prompt treatment with riboflavin showed good results. Read More

View Article

Download full-text PDF

Source
http://www.pediatricneurosciences.com/text.asp?2018/13/4/471
Publisher Site
http://dx.doi.org/10.4103/JPN.JPN_131_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413615PMC
April 2019
2 Reads

Personality and burnout among primary care physicians: an international study.

Psychol Res Behav Manag 2019 18;12:169-177. Epub 2019 Mar 18.

Department of Family and Community Medicine, St. Michael's Hospital, Toronto, ON, Canada.

Purpose: Burnout is a syndrome comprised of three major dimensions, namely, emotional exhaustion, depersonalization, and reduced personal accomplishment. Its etiology appears to be multifactorial, involving work-related and personal factors including personality traits. Personality has been associated with burnout among various physician groups; however, this has not been studied well amongst primary care physicians. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/PRBM.S195633DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430002PMC
March 2019
4 Reads

Interactive and potentially independent roles of renin-angiotensin-aldosterone system blockade and the development of cardiorenal syndrome type 1 on in-hospital mortality among elderly patients admitted with acute decompensated congestive heart failure.

Int J Nephrol Renovasc Dis 2019 14;12:33-48. Epub 2019 Mar 14.

Department of Medicine, Section of Nephrology, University of Illinois at Chicago, Chicago, IL, USA.

Purpose: Cardiorenal syndrome type 1 (CRS1), defined as worsening renal function from acute decompensated congestive heart failure (ADCHF), is complicated by the fact that CRS1 limits the use of common therapeutic strategies, such as angiotensin converting-enzyme inhibitors (ACEIs) or angiotensin II-receptor blockers (A2RB). The present study examines retrospectively the role of ACEI/A2RB usage on in-hospital mortality among elderly ADCHF patients, in particular those who developed CRS1.

Methods: We retrospectively examined the effects of ACEI/A2RB usage and CRS1 development (in-hospital change in serum creatinine ≥0. Read More

View Article

Download full-text PDF

Source
https://www.dovepress.com/interactive-and-potentially-indepe
Publisher Site
http://dx.doi.org/10.2147/IJNRD.S185988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421894PMC
March 2019
6 Reads

Perception of prescription drug monitoring programs as a prevention tool in primary medical care.

Res Social Adm Pharm 2019 Mar 26. Epub 2019 Mar 26.

University of Florida, College of Medicine, Department of Obstetrics and Gynecology, Gainesville, FL, USA.

Background: Prescription drug monitoring programs (PDMPs) are primary prevention tools to reduce substance use disorders (SUD) and sequelae. Evidence regarding perceptions of PDMPs from different primary care providers, which may impact PDMP utilization for women, is unavailable.

Objective: To examine perceived PDMP effectiveness among obstetrician-gynecologists (OB/GYNs) compared to primary care physicians (PCPs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.sapharm.2019.03.012DOI Listing
March 2019
2 Reads

Case Report of gastroparesis healing: 16 years of a chronic syndrome resolved after proximal intercessory prayer.

Complement Ther Med 2019 Apr 9;43:289-294. Epub 2019 Mar 9.

Global Medical Research Institute, United States; Indiana University, Bloomington IN, United States. Electronic address:

A male infant at two weeks of age was hospitalized vomiting forcefully. He had a pyloromyotomy. He did not improve with medical therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ctim.2019.03.004DOI Listing
April 2019
1 Read

Anti-Obesity and Anti-Diabetic Effects of .

Mar Drugs 2019 Mar 29;17(4). Epub 2019 Mar 29.

Department of Marine Life Science, Jeju National University, Jeju 63243, Korea.

Obesity is associated with several health complications and can lead to the development of metabolic syndrome. Some of its deleterious consequences are related to insulin resistance, which adversely affects blood glucose regulation. At present, there is a growing concern regarding healthy food consumption, owing to awareness about obesity. Read More

View Article

Download full-text PDF

Source
https://www.mdpi.com/1660-3397/17/4/202
Publisher Site
http://dx.doi.org/10.3390/md17040202DOI Listing
March 2019
3 Reads

[Clinical analysis of 22 cases of syndrome caused by acute poisoning].

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2019 Feb;37(2):136-138

The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

To analyze the clinical characteristics, treatment and prognosis of rhabdomyolysis (RM) caused by acute poisoning.Summarize the clinical characteristics and treatment experience, pay attention to the complications and improve the quality of rescue. We collecte and summarize the clinical data, treatment and prognosis of 22 cases of RM caused by acute poisoning. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.1001-9391.2019.02.012DOI Listing
February 2019
1 Read

Thalamo-cortical network hyperconnectivity in preclinical progranulin mutation carriers.

Neuroimage Clin 2019 Mar 16;22:101751. Epub 2019 Mar 16.

University of California, Memory and Aging Center, Department of Neurology, San Francisco, United States; University of California, Department of Pathology, San Francisco, United States.

Mutations in progranulin (GRN) cause heterogeneous clinical syndromes, including behavioral variant frontotemporal dementia (bvFTD), primary progressive aphasia (PPA), corticobasal syndrome (CBS) and Alzheimer-type dementia (AD-type dementia). Human studies have shown that presymptomatic GRN carriers feature reduced connectivity in the salience network, a system targeted in bvFTD. Mice with homozygous deletion of GRN, in contrast, show thalamo-cortical hypersynchrony due to aberrant pruning of inhibitory synapses onto thalamo-cortical projection neurons. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nicl.2019.101751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438992PMC
March 2019
4 Reads

Dolutegravir-Based Antiretroviral Therapy for Patients Co-Infected with Tuberculosis and Hiv: A Multicenter, Noncomparative, Open-Label, Randomized Trial.

Clin Infect Dis 2019 Mar 28. Epub 2019 Mar 28.

ViiV Healthcare Ltd., Brentford, UK.

Background: Concurrent treatment of tuberculosis and HIV is challenging owing to drug interactions, overlapping toxicities, and immune reconstitution inflammatory syndrome (IRIS). The efficacy and safety of dolutegravir were assessed in adults with HIV and drug-susceptible tuberculosis.

Methods: INSPIRING (NCT02178592) is a non-comparative, active-control, randomised, open-label study in HIV-1-infected ART-naïve adults (CD4+ 50 cells/mm3). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciz256DOI Listing
March 2019
1 Read

[Laurine fatty acids, medium fatty acids and triglycerides, hyperlipidemia, resistance to insulin, prevention of atherosclerosis and ateromatosis.]

Klin Lab Diagn 2019 ;64(2):68-77

FGAOU VO "Northern (Arctic) Federal University, M.V. Lomonosov", Arkhangelsk.

Although the biochemistry of the positive effects of medium-chain fatty acids (FA) and triglycerides (TG) of the same name in vivo is not fully understood, food enriched with medium-chain LC and the same TG is effective in patients with type I diabetes, insulin resistance syndrome and in neurodegenerative pathology. Lauric C12 LC is half the FA in coconut oil. Residents of southeast Asia with constant use of coconut oil, have a low level of diseases of the cardiovascular system in the population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18821/0869-2084-2019-64-2-68-77DOI Listing
January 2019

Efficacy and Tolerability of Adjunctive Intravenous Sodium Nitroprusside Treatment for Outpatients With Schizophrenia: A Randomized Clinical Trial.

JAMA Psychiatry 2019 Mar 27. Epub 2019 Mar 27.

Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston.

Importance: Antipsychotic medications for the treatment of schizophrenia have limitations, and new treatments are needed. A prior pilot investigation suggested that adjunctive sodium nitroprusside (SNP) administered intravenously had rapid efficacy in the treatment of patients with schizophrenia.

Objective: To determine the efficacy and tolerability of intravenous SNP infused at a rate of 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamapsychiatry.2019.0151DOI Listing

Changes and Significance of SYP and GAP-43 Expression in the Hippocampus of CIH Rats.

Int J Med Sci 2019 29;16(3):394-402. Epub 2019 Jan 29.

Department of Neurology, Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Zunyi, Guizhou, China, 563003.

Synaptophysin (SYP) and growth-associated binding protein 43 (GAP-43) have been shown to be closely related to hippocampal synaptic plasticity in recent years. They are important molecular markers associated with synaptic plasticity. However, the role of SYP and GAP-43 in chronic intermittent hypoxic injury of the central nervous system needs to be further clarified. Read More

View Article

Download full-text PDF

Source
http://www.medsci.org/v16p0394.htm
Publisher Site
http://dx.doi.org/10.7150/ijms.28359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428973PMC
January 2019
3 Reads

Acquired Pediatric Brown Syndrome Secondary to Sinusitis.

J Pediatr Ophthalmol Strabismus 2019 Mar 25;56:e17-e19. Epub 2019 Mar 25.

Acquired pediatric Brown syndrome is rarely associated with sinusitis. Children may present with diplopia, elevation deficiency in adduction, and a head tilt or chin-up position. Magnetic resonance imaging can confirm the diagnosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3928/01913913-20190213-01DOI Listing
March 2019
1 Read

Phenotype and Variant Spectrum in the LAMB3 Form of Amelogenesis Imperfecta.

J Dent Res 2019 Mar 24:22034519835205. Epub 2019 Mar 24.

7 School of Dentistry, University of Leeds, Leeds, UK.

Amelogenesis imperfecta (AI) is a heterogeneous group of inherited disorders characterized by abnormal formation of dental enamel, either in isolation or as part of a syndrome. Heterozygous variants in laminin subunit beta 3 ( LAMB3) cause AI with dominant inheritance in the absence of other cosegregating clinical features. In contrast, biallelic loss-of-function variants in LAMB3 cause recessive junctional epidermolysis bullosa, characterized by life-threatening skin fragility. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0022034519835205DOI Listing

Challenges in the treatment of parathyroid carcinoma: a case report.

Hormones (Athens) 2019 Mar 23. Epub 2019 Mar 23.

Endocrinology, Department of Clinical and Experimental Medicine, Garibaldi-Nesima Hospital, University of Catania, Via Palermo 636, 95122, Catania, Italy.

Introduction: Parathyroid carcinoma (PC) is a rare neoplasm with a high rate of recurrence and an indolent course. It is frequently functional, causing nearly 1% of the cases of primary hyperparathyroidism (HPT), and in some cases, it may be complicated by brown tumors, mimicking bone metastases. Synchronous parathyroid and papillary thyroid carcinomas are rare. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s42000-019-00104-wDOI Listing
March 2019
2 Reads

Prevalence of ophthalmic disorders among hearing-impaired school children in Guntur district of Andhra Pradesh.

Indian J Ophthalmol 2019 Apr;67(4):530-535

Gullapalli Pratibha Rao International Centre for Advancement in Rural Eye Care (GPR-ICARE), L V Prasad Eye Institute, Hyderabad, Andhra Pradesh, India.

Purpose: To estimate the prevalence, causes, and risk factors for visual impairment (VI) among children of school for hearing-impaired (HI) in Guntur district of Andhra Pradesh, India.

Methods: Children between 6 and 16 years of age available in all the 12 special schools for HI were examined. Visual acuity (VA) testing, ocular motility, and examination of anterior and posterior segment for all children were done. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijo.IJO_995_18DOI Listing
April 2019
4 Reads

Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome.

Autophagy 2019 Mar 22:1-17. Epub 2019 Mar 22.

a State Key Laboratory of Membrane Biology, Institute of Zoology , Chinese Academy of Sciences , Beijing , China.

There is overwhelming evidence for an association between impaired mitochondrial function and metabolic syndrome. Mitophagy, a process that selectively removes damaged mitochondria via a specialized form of autophagy, is essential for mitochondrial quality control (mitochondrial QC) and metabolic homeostasis. We thus addressed the potential role of defective mitophagy in the pathogenesis of metabolic disorders. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15548627.2019.1596482DOI Listing
March 2019
4 Reads
11.753 Impact Factor