48,410 results match your criteria Brown Syndrome


Response to Letter to the Editor.

Tremor Other Hyperkinet Mov (N Y) 2019 6;9:630. Epub 2019 Feb 6.

Department of Neurology, Butler Hospital, Warren Alpert Medical School of Brown University, Providence, RI, US.

In Response To: Walker RH. Reply to: Tardive dyskinesia-like syndrome due to drugs that do not block dopamine receptors: rare or non-existent: literature review. Tremor Other Hyperkinet Mov. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7916/0rjw-cv10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377913PMC
February 2019

First Report of Sudden Death Syndrome of Soybean in Wisconsin.

Plant Dis 2007 Sep;91(9):1201

Department of Plant Pathology, University of Wisconsin, Madison.

In August of 2006, soybean (Glycine max (L.) Merr.) plants collected from Columbia, Dane, Green Lake, Walworth, Jefferson, and Waushara counties in southern Wisconsin exhibited symptoms typical of sudden death syndrome (SDS) caused by Fusarium virguliforme O'Donnell & Aoki [synonym F. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1094/PDIS-91-9-1201BDOI Listing
September 2007

How do genes that escape from X-chromosome inactivation contribute to Turner syndrome?

Am J Med Genet C Semin Med Genet 2019 Feb 19. Epub 2019 Feb 19.

Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.

X-chromosome inactivation generally results in dosage equivalence for expression of X-linked genes between 46,XY males and 46,XX females. The 20-30% of genes that escape silencing are thus candidates for having a role in the phenotype of Turner syndrome. Understanding which genes escape from silencing, and how they avoid this chromosome-wide inactivation is therefore an important step toward understanding Turner Syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.c.31672DOI Listing
February 2019

Higher fat stores contribute to persistence of little brown bat populations with white-nose syndrome.

J Anim Ecol 2019 Feb 18. Epub 2019 Feb 18.

Department of Ecology and Evolutionary Biology, University of California, UC Santa Cruz, California.

The persistence of populations declining from novel stressors depends, in part, on their ability to respond by trait change via evolution or plasticity. White-nose syndrome (WNS) has caused rapid declines in several North America bat species by disrupting hibernation behaviour, leading to body fat depletion and starvation. However, some populations of Myotis lucifugus now persist with WNS by unknown mechanisms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1365-2656.12954DOI Listing
February 2019

Basic and translational neuro-ophthalmology of visually guided saccades: disorders of velocity.

Expert Rev Ophthalmol 2017 28;12(6):457-473. Epub 2017 Nov 28.

Dept. of Neurology, University Hospitals Cleveland Medical Center and Case Western Reserve University, Cleveland, Ohio, United States.

Introduction: Saccades are rapid, yoked eye movements in an effort to direct a target over fovea. The complex circuitry of saccadic eye movements has been exhaustively described. As a result clinicians can elegantly localize the pathology if it falls on the neuraxis responsible for saccades. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/17469899.2017.1395695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377082PMC
November 2017

Expanding the genetic and clinical spectrum of the NONO-associated X-linked intellectual disability syndrome.

Am J Med Genet A 2019 Feb 17. Epub 2019 Feb 17.

Division of Medical Genetics, University of Utah, Salt Lake City, Utah.

The NONO gene encodes a nuclear protein involved in RNA metabolism. Hemizygous loss-of-function NONO variants have been associated with syndromic intellectual disability and with left ventricular noncompaction (LVNC). A two-year-old boy presented to the University of Utah's Penelope Undiagnosed Disease Program with developmental delay, nonfamilial features, relative macrocephaly, and dilated cardiomyopathy with LVNC and Ebstein anomaly. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.a.61091DOI Listing
February 2019
1 Read

Hunting for a cause of painful diplopia.

Authors:
Benjamin Nham

Med J Aust 2019 Feb 18. Epub 2019 Feb 18.

Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, NSW.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5694/mja2.50042DOI Listing
February 2019
1 Read

Exposure to Cold Unmasks Potential Biomarkers of Fibromyalgia Syndrome Reflecting Insufficient Sympathetic Responses to Stress.

Clin J Pain 2019 Feb 12. Epub 2019 Feb 12.

Dept. Veterinary and Biomedical Sciences, University of Minnesota, St. Paul MN.

Objectives: Fibromyalgia syndrome (FMS) is a chronically painful condition whose symptoms are widely reported to be exacerbated by stress. We hypothesized that female patients with FMS differ from healthy female controls in their sympathetic responses, a fact that may unmask important biomarkers and factors that contribute to the etiology of FMS.

Methods: In a pilot study, blood pressure (BP), skin temperature, thermogenic activity, circulating glucose, and pain sensitivity of 13 patients and 11 controls at room temperature (24°C) were compared to that after exposure to cold (19°C). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/AJP.0000000000000695DOI Listing
February 2019
2 Reads

Serotonin Transporter Deficiency is Associated with Dysbiosis and Changes in Metabolic Function of the Mouse Intestinal Microbiome.

Sci Rep 2019 Feb 14;9(1):2138. Epub 2019 Feb 14.

Division of Gastroenterology & Hepatology, University of Illinois at Chicago, Chicago, USA.

Serotonin transporter (SERT) plays a critical role in regulating extracellular availability of serotonin (5-HT) in the gut and brain. Mice with deletion of SERT develop metabolic syndrome as they age. Changes in the gut microbiota are being increasingly implicated in Metabolic Syndrome and Diabetes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-38489-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375953PMC
February 2019
2 Reads

Phase I Trial of Inducible Caspase 9 T Cells in Adult Stem Cell Transplant Demonstrates Massive Clonotypic Proliferative Potential and Long-term Persistence of Transgenic T Cells.

Clin Cancer Res 2019 Feb 14. Epub 2019 Feb 14.

QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.

Inducible caspase 9 () is a cellular safety switch that can make T-cell therapy safer. The purpose of this phase I trial was to investigate the use of -transduced T-cell addback in adult patients undergoing haploidentical stem cell transplantation for high-risk hematologic malignancies. Patients undergoing myeloablative, CD34-selected haploidentical stem cell transplantation were treated with 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1158/1078-0432.CCR-18-3069DOI Listing
February 2019
1 Read

Sociodemographic patterns of urine sodium excretion and its association with hypertension in Chile: a cross-sectional analysis.

Public Health Nutr 2019 Feb 14:1-10. Epub 2019 Feb 14.

1BHF Glasgow Cardiovascular Research Centre,Institute of Cardiovascular and Medical Science,University of Glasgow,Glasgow G12 8TA,UK.

Objective: The aim of the study was to determine the main factors (sociodemographic, anthropometric, lifestyle and health status) associated with high Na excretion in a representative population of Chile.

Design: Na excretion (g/d), a valid marker of Na intake, was determined by urine analysis and Tanaka's formulas. Blood pressure was measured by trained staff and derived from the mean of three readings recorded after 15 min rest. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S1368980018003889DOI Listing
February 2019

Exercise, or exercise and diet for the management of polycystic ovary syndrome: a systematic review and meta-analysis.

Syst Rev 2019 Feb 12;8(1):51. Epub 2019 Feb 12.

Aston Medical Research Institute, Aston Medical School, Aston University, Birmingham, B4 7ET, UK.

Background: Typically, management of PCOS focuses on lifestyle changes (exercise and diet), aiming to alleviate symptoms, and lower the associated risk of type 2 diabetes and cardiovascular disease. Our objective was to analyse evidence on the effectiveness of exercise in the management of PCOS, when compared to (i) usual care, (ii) diet alone, and (iii) exercise combined with diet, and also exercise combined with diet, compared to (i) control or usual care and (ii) diet alone.

Methods: Relevant databases were searched (June 2017) with no time limit for trial inclusion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13643-019-0962-3DOI Listing
February 2019
1 Read

High Pancreatic Amylase Expression Promotes Adiposity in Obesity-Prone Carbohydrate-Sensitive Rats.

J Nutr 2019 Feb 8. Epub 2019 Feb 8.

UMR Physiologie de la Nutrition et du Comportement Alimentaire, AgroParisTech, INRA, Université Paris Saclay, Paris, France.

Background: We have reported large differences in adiposity (fat mass/body weight) gain between rats fed a low-fat, high-starch diet, leading to their classification into carbohydrate "sensitive" and "resistant" rats. In sensitive animals, fat accumulates in visceral adipose tissues, leading to the suggestion that this form of obesity could be responsible for rapid development of metabolic syndrome.

Objective: We investigated whether increased amylase secretion by the pancreas and accelerated starch degradation in the intestine could be responsible for this phenotype. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jn/nxy262DOI Listing
February 2019

Carotid-cavernous fistula(CCF) presenting as paroxysmal painful ophthalmoplegia.

BMC Ophthalmol 2019 Feb 11;19(1):48. Epub 2019 Feb 11.

Department of Neurology, Shandong Provincial Hospital affiliated to Shandong University, No 324, Jingwu Road, Huaiyin Zone, Jinan, Shandong Province, 250012, People's Republic of China.

Background: Painful ophthalmoplegia can be caused by various etiologies, and broad differential diagnosis is needed. Carotid-cavernous fistula (CCF) is a rare cause of painful ophthalmoplegia, and early diagnosis is quite difficult.

Case Presentation: Here, we present a case of paroxysmal painful ophthalmoplegia caused by CCF. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12886-019-1039-8DOI Listing
February 2019

A Regression Model for Prediction of Cesarean-Associated Blood Transfusion.

Am J Perinatol 2019 Feb 11. Epub 2019 Feb 11.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Women and Infants Hospital, Alpert Medical School of Brown University, Providence, Rhode Island.

Objective:  To develop a model to predict cesarean-associated red blood cell transfusion.

Study Design:  Secondary analysis of all cesarean deliveries in the Maternal-Fetal Medicine Units Network Cesarean Registry. Using a split-sample technique, the derivation group was used to identify associated factors and build predictive models, and the validation group was used to estimate classification errors and determine test characteristics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1678604DOI Listing
February 2019
1 Read

Hip muscle response to a fatiguing run in females with iliotibial band syndrome.

Hum Mov Sci 2019 Feb 8;64:181-190. Epub 2019 Feb 8.

Leon Root, MD Motion Analysis Laboratory, Hospital for Special Surgery, 510 East 73rd Street, New York, NY 10021, USA.

Impaired hip muscle function has often been cited as a contributing factor to the development of iliotibial band syndrome (ITBS), yet our full understanding of this relationship is not well established. The objective of this study was to examine the effect of fatigue on hip abductor muscle function in females with ITBS. Female runners, 20 healthy and 12 with a current diagnosis of ITBS, performed a treadmill run to fatigue. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.humov.2019.02.002DOI Listing
February 2019
2 Reads

Development of a core outcome set for amblyopia, strabismus and ocular motility disorders: a review to identify outcome measures.

BMC Ophthalmol 2019 Feb 8;19(1):47. Epub 2019 Feb 8.

Department of Health Services Research, University of Liverpool, Waterhouse Building Block B, 2nd Floor, 1-3 Brownlow Street, L69 3GL, Liverpool, UK.

Background: Core Outcome Sets (COS) are defined as the minimum sets of outcomes that should be measured and reported in all randomised controlled trials to facilitate combination and comparability of research. The aim of this review is to produce an item bank of previously reported outcome measures from published studies in amblyopia, strabismus and ocular motility disorders to initiate the development of COS.

Methods: A review was conducted to identify articles reporting outcome measures for amblyopia, strabismus and ocular motility disorders. Read More

View Article

Download full-text PDF

Source
https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
Publisher Site
http://dx.doi.org/10.1186/s12886-019-1055-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368710PMC
February 2019
4 Reads

Pioglitazone Therapy in Patients With Stroke and Prediabetes: A Post Hoc Analysis of the IRIS Randomized Clinical Trial.

JAMA Neurol 2019 Feb 7. Epub 2019 Feb 7.

Department of Medicine, Yale School of Medicine, New Haven, Connecticut.

Importance: In the Insulin Resistance Intervention After Stroke (IRIS) randomized clinical trial, pioglitazone, an insulin-sensitizing agent, reduced the risk for recurrent stroke or myocardial infarction (MI) among patients with insulin resistance. However, insulin resistance is not commonly measured in clinical practice.

Objective: To analyze the effects of pioglitazone in patients with good adherence as well as intention-to-treat effects of pioglitazone in patients with prediabetes in the IRIS trial. Read More

View Article

Download full-text PDF

Source
http://archneur.jamanetwork.com/article.aspx?doi=10.1001/jam
Publisher Site
http://dx.doi.org/10.1001/jamaneurol.2019.0079DOI Listing
February 2019
4 Reads

Dementia in Down syndrome: unique insights for Alzheimer disease research.

Nat Rev Neurol 2019 Feb 7. Epub 2019 Feb 7.

Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA.

Virtually all adults with Down syndrome (DS) show the neuropathological changes of Alzheimer disease (AD) by the age of 40 years. This association is partially due to overexpression of amyloid precursor protein, encoded by APP, as a result of the location of this gene on chromosome 21. Amyloid-β accumulates in the brain across the lifespan of people with DS, which provides a unique opportunity to understand the temporal progression of AD and the epigenetic factors that contribute to the age of dementia onset. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41582-018-0132-6DOI Listing
February 2019
1 Read

Abnormal Eye Movements in Parkinsonism and Movement Disorders.

J Mov Disord 2019 Jan 30;12(1):1-13. Epub 2019 Jan 30.

Department of Neurology, Korea University College of Medicine, Korea University Ansan Hospital, Ansan.

Abnormal eye movements are commonly observed in movement disorders. Ocular motility examination should include bedside evaluation and laboratory recording of ocular misalignment, involuntary eye movements, including nystagmus and saccadic intrusions/oscillations, triggered nystagmus, saccades, smooth pursuit (SP), and the vestibulo-ocular reflex. Patients with Parkinson's disease (PD) mostly show hypometric saccades, especially for the selfpaced saccades, and impaired SP. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.14802/jmd.18034DOI Listing
January 2019

Francisella tularensis Transmission by Solid Organ Transplantation, 2017.

Emerg Infect Dis 2019 Apr 17;25(4). Epub 2019 Apr 17.

In July 2017, fever and sepsis developed in 3 recipients of solid organs (1 heart and 2 kidneys) from a common donor in the United States; 1 of the kidney recipients died. Tularemia was suspected only after blood cultures from the surviving kidney recipient grew Francisella species. The organ donor, a middle-aged man from the southwestern United States, had been hospitalized for acute alcohol withdrawal syndrome, pneumonia, and multiorgan failure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3201/eid2504.181807DOI Listing
April 2019
1 Read

Oesophageal obstruction due to trichobezoars in two cats.

JFMS Open Rep 2019 Jan-Jun;5(1):2055116918823581. Epub 2019 Jan 14.

Animal Referral Hospital, Homebush, NSW, Australia.

Case Series Summary: This case series describes two cats diagnosed with oesophageal obstruction due to trichobezoars. Both cases presented for acute dyspnoea, with thoracic radiographs revealing changes consistent with oesophageal foreign material causing ventral displacement of the trachea. Endoscopic removal was unsuccessful and both cases required surgical intervention. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2055116918823581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350137PMC
January 2019
1 Read

The "Obsessive Paradox": The Complex Relationship Between Cognitive and Obsessive Dimensions in Schizophrenia.

J Nerv Ment Dis 2019 Jan 31. Epub 2019 Jan 31.

Department of Neuroscience, Psychiatric Unit, University of Parma, Parma, Italy.

The objective of the study was to investigate the relationship between cognitive functions and obsessive-compulsive dimension in schizophrenia and a possible moderating effect of schizophrenia symptom dimensions on this association. Sixty-one schizophrenia patients were administered the Positive and Negative Syndrome Scale, the Yale-Brown Obsessive-Compulsive Scale (YBOCS), and the Matrics Consensus Cognitive Battery. A U-shaped curve described a gradual transition from an inverse association to a positive relationship between YBOCS and processing speed scores, along a severity gradient of obsessive dimension. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/NMD.0000000000000932DOI Listing
January 2019
1 Read

[Brown's syndrome].

J Fr Ophtalmol 2019 Feb 31;42(2):189-197. Epub 2019 Jan 31.

Service d'ophtalmologie, CHU Secteur Nord Marseille, chemin des Bourrély, 13015 Marseille, France.

Brown's syndrome is related to an abnormality of the superior oblique muscle: it is manifested by an oculomotor disorder with active and passive limitation of elevation in adduction, the field of action of the inferior oblique muscle. The origin is congenital or acquired secondary to multiple causes - inflammatory-infectious, traumatic or iatrogenic. The clinical and paraclinical signs are suggestive. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jfo.2018.06.012DOI Listing
February 2019
1 Read

Acquired reversible Brown syndrome caused by focal abscess of superior oblique muscle.

J AAPOS 2019 Jan 30. Epub 2019 Jan 30.

Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

A 16-year-old boy with a history of relapsed acute myeloid leukemia and a right lower lobe lung abscess confirmed to be Aspergillus presented for a baseline eye examination prior to consideration of bone marrow transplantation. He noted double vision in up-and-left gaze, and his examination was consistent with an acquired right-sided Brown syndrome. Magnetic resonance imaging revealed a 4 mm rim-enhancing inflammatory focus in the right superior oblique muscle. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jaapos.2018.12.003DOI Listing
January 2019
1 Read

Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice.

Kidney Int 2019 Mar 30;95(3):590-610. Epub 2019 Jan 30.

Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado, USA; Denver VA Medical Center, Division of Nephrology, Department of Medicine, Denver, Colorado, USA. Electronic address:

Acute kidney injury (AKI) is a systemic disease associated with widespread effects on distant organs, including the heart. Normal cardiac function is dependent on constant ATP generation, and the preferred method of energy production is via oxidative phosphorylation. Following direct ischemic cardiac injury, the cardiac metabolome is characterized by inadequate oxidative phosphorylation, increased oxidative stress, and increased alternate energy utilization. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.kint.2018.10.020DOI Listing
March 2019
1 Read

Acute Respiratory Failure from Cement Exposure: A Case Report and Review of the Literature.

R I Med J (2013) 2019 Feb 1;102(1):55-57. Epub 2019 Feb 1.

Department of Emergency Medicine, and Division of Emergency Toxicology, Brown Emergency Medicine, 55 Claverick Street, Suite 100, Providence, RI.

Cement is widely used in construction. Acute exposures with immediate sequelae have been infrequently described. This case report describes a man who developed multifocal pneumonitis with acute respiratory distress syndrome (ARDs) and respiratory failure one day after cement dust exposure. Read More

View Article

Download full-text PDF

Source
February 2019
3 Reads

Examination of the Patient with Dizziness or Imbalance.

Med Clin North Am 2019 Mar 3;103(2):191-201. Epub 2018 Dec 3.

Department of Otolaryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Massachusetts Eye and Ear Balance and Vestibular Center, 250 Pond Street, Braintree, MA 02184, USA. Electronic address:

Dizziness and imbalance are common and challenging chief complaints carrying high morbidity, due to their association with falls, injuries, and loss of quality of life. The physical examination represents an opportunity to collect objective clinical data that facilitate an understanding of symptoms that might otherwise be enigmatic and ineffable. This review focuses on the examination techniques used routinely by physicians who provide specialized care for patients with dizziness and imbalance. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00257125183013
Publisher Site
http://dx.doi.org/10.1016/j.mcna.2018.10.008DOI Listing
March 2019
2 Reads

Cardiac Dysfunction Among People Living With HIV: A Systematic Review and Meta-Analysis.

JACC Heart Fail 2019 Feb;7(2):98-108

South African Medical Research Council and University of Cape Town, South Africa.

Objective: To synthesize existing epidemiological data on cardiac dysfunction in HIV.

Background: Data on the burden and risk of human immunodeficiency virus (HIV) infection-associated cardiac dysfunction have not been adequately synthesized. We performed meta-analyses of extant literature on the frequency of several subtypes of cardiac dysfunction among people living with HIV. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22131779183076
Publisher Site
http://dx.doi.org/10.1016/j.jchf.2018.10.006DOI Listing
February 2019
3 Reads

Antiviral Responses and Biological Concequences of Infection in Salmonid Erythrocytes.

Front Immunol 2018 16;9:3182. Epub 2019 Jan 16.

Department of Fish Health, Norwegian Veterinary Institute, Oslo, Norway.

Salmonid red blood cells are the main target cells for (PRV). Three genotypes of PRV (PRV-1,2,3) infect Atlantic salmon (), Chinook salmon (), Coho salmon (), rainbow trout () and brown trout (Salmo trutta), and can cause diseases like heart and skeletal muscle inflammation (HSMI), jaundice syndrome, erythrocyte inclusion body syndrome (EIBS) and proliferative darkening syndrome (PDS). Purified PRV administrated to fish has proven the causality for HSMI and EIBS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fimmu.2018.03182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343427PMC
January 2019

Pharmacomechanical Catheter-Directed Thrombolysis in Acute Femoral-Popliteal Deep Vein Thrombosis: Analysis from a Stratified Randomized Trial.

Thromb Haemost 2019 Jan 30. Epub 2019 Jan 30.

Department of Radiology, Washington University in St. Louis, St. Louis, Missouri, United States.

Background And Objectives:  The Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis (ATTRACT) trial reported that pharmacomechanical catheter-directed thrombolysis (PCDT) did not reduce post-thrombotic syndrome (PTS), but reduced moderate-to-severe PTS and the severity of PTS symptoms. In this analysis, we examine the effect of PCDT in patients with femoral-popliteal deep vein thrombosis (DVT) (without involvement of more proximal veins).

Patients And Methods:  Within the ATTRACT trial, 300 patients had DVT involving the femoral vein without involvement of the common femoral or iliac veins and were randomized to receive PCDT with anticoagulation or anticoagulation alone (no PCDT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0039-1677795DOI Listing
January 2019

Piscine Orthoreovirus 3 Is Not the Causative Pathogen of Proliferative Darkening Syndrome (PDS) of Brown Trout ().

Viruses 2019 Jan 28;11(2). Epub 2019 Jan 28.

Institute for Infectious Diseases and Zoonoses, Department for Veterinary Sciences, LMU Munich, 80539 Munich, Germany.

The proliferative darkening syndrome (PDS) is a lethal disease of brown trout () which occurs in several alpine Bavarian limestone rivers. Because mortality can reach 100%, PDS is a serious threat for affected fish populations. Recently, Kuehn and colleagues reported that a high throughput RNA sequencing approach identified a piscine orthoreovirus (PRV) as a causative agent of PDS. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/v11020112DOI Listing
January 2019

The Neuropsychological Syndrome of Agenesis of the Corpus Callosum.

J Int Neuropsychol Soc 2019 Jan 29:1-7. Epub 2019 Jan 29.

2California Institute of Technology,Division of Humanities and Social Sciences,Pasadena,California.

Background: Agenesis of the corpus callosum (AgCC) involves congenital absence of all or part of the corpus callosum. Because the disorder can only be firmly diagnosed via neuroradiology, it has a short research history, and only recently has the cognitive syndrome become clear.

Purpose: Our purpose is to review the primary deficits in AgCC that constitute the core syndrome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S135561771800111XDOI Listing
January 2019

Interactions between the cecal microbiota and non-alcoholic steatohepatitis using laying hens as the model.

Poult Sci 2019 Jan 24. Epub 2019 Jan 24.

State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, P. R. China.

The chronic liver disease has caused increasing numbers of deaths worldwide. Fatty liver hemorrhagic syndrome, one of the chronic liver diseases in laying hens, has great similarity to non-alcoholic fatty liver disease (NAFLD) in humans. It is characterized by the pathological accumulation of liver fat. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3382/ps/pey596DOI Listing
January 2019

Regulation of Adaptive Thermogenesis and Browning by Prebiotics and Postbiotics.

Front Physiol 2018 10;9:1908. Epub 2019 Jan 10.

CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Madrid, Spain.

Prebiotics are non-digestible food components able to modify host microbiota toward a healthy profile, concomitantly conferring general beneficial health effects. Numerous research works have provided wide evidence regarding the effects of prebiotics on the protection against different detrimental phenotypes related to cancer, immunity, and features of the metabolic syndrome, among others. Nonetheless, one topic less studied so far, but relevant, relates to the connection between prebiotics and energy metabolism regulation (and the prevention or treatment of obesity), especially by means of their impact on adaptive (non-shivering) thermogenesis in brown adipose tissue (BAT) and in the browning of white adipose tissue (WAT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3389/fphys.2018.01908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335971PMC
January 2019

Environmental Pollutants Effect on Brown Adipose Tissue.

Front Physiol 2018 9;9:1891. Epub 2019 Jan 9.

Department of Chemistry and Biology "A. Zambelli", University of Salerno, Fisciano, Italy.

Brown adipose tissue (BAT) with its thermogenic function due to the presence of the mitochondrial uncoupling protein 1 (UCP1), has been positively associated with improved resistance to obesity and metabolic diseases. During recent years, the potential influence of environmental pollutants on energetic homoeostasis and obesity development has drawn increased attention. The purpose of this review is to discuss how regulation of BAT function could be involved in the environmental pollutant effect on body energy metabolism. Read More

View Article

Download full-text PDF

Source
https://www.frontiersin.org/article/10.3389/fphys.2018.01891
Publisher Site
http://dx.doi.org/10.3389/fphys.2018.01891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333681PMC
January 2019
4 Reads

Sjögren's Syndrome: More Than Just Dry Eye.

Cornea 2019 Jan 22. Epub 2019 Jan 22.

Department of Health Services, Policy, and Practice, Center for Evidence Synthesis in Health, Brown University School of Public Health, Providence, RI.

Purpose: Sjögren's syndrome (SS) is a common autoimmune disease affecting about four million Americans. Although approximately 1 in 10 patients with clinically-significant aqueous deficient dry eye has underlying SS, widespread underappreciation of SS leads to significant underdiagnosis, delays in diagnosis, and consequent morbidity and mortality. The purpose of this article is to illustrate that in addition to dry eye, SS can cause serious, vision-threatening extraglandular ocular manifestations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/ICO.0000000000001865DOI Listing
January 2019
3 Reads

Zfp238 Regulates the Thermogenic Program in Cooperation with Foxo1.

iScience 2019 Jan 7;12:87-101. Epub 2019 Jan 7.

Navigation Medicine of Kidney and Metabolism, Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan.

Obesity has become an explicit public health concern because of its relevance to metabolic syndrome. Evidence points to the significance of beige adipocytes in regulating energy expenditure. Here, using yeast two-hybrid screening, we show that Zfp238 is a Foxo1 co-repressor and that adipose-tissue-specific ablation of Zfp238 (Adipo-Zfp238KO) in mice leads to obesity, decreased energy expenditure, and insulin resistance under normal chow diet. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.isci.2019.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6352565PMC
January 2019
2 Reads

ALG11-CDG syndrome: Expanding the phenotype.

Am J Med Genet A 2019 Mar 24;179(3):498-502. Epub 2019 Jan 24.

Clinical Genetics, Stanford Children's Health, Palo Alto, California.

ALG11-Congenital Disorder of Glycosylation (ALG11-CDG, also known as congenital disorder of glycosylation type Ip) is an inherited inborn error of metabolism due to abnormal protein and lipid glycosylation. We describe two unrelated patients with ALG11-CDG due to novel mutations, review the literature of previously described affected individuals, and further expand the clinical phenotype. Both affected individuals reported here had severe psychomotor disabilities and epilepsy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/ajmg.a.61046DOI Listing

Myeloid Sarcoma with Megakaryoblastic Differentiation Arising in the Conjunctiva.

Ocul Oncol Pathol 2019 Jan 22;5(1):28-35. Epub 2018 May 22.

Eyelid Experts, Palm Beach Gardens, Florida, USA.

An 87-year-old woman not known to have either a lymphoma or leukemia developed a left multinodular, fish-flesh superior epibulbar and forniceal mass. A biopsy disclosed a blastic tumor with scattered multinucleated immature megakaryoblasts. Immunophenotyping of bone marrow cells revealed strong positivity for CD7, CD31, CD43, CD45, CD61, and CD117; CD71, myeloperoxidase, and lysozyme were also positive in scattered cells. Read More

View Article

Download full-text PDF

Source
https://www.karger.com/Article/FullText/488057
Publisher Site
http://dx.doi.org/10.1159/000488057DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341420PMC
January 2019
4 Reads

Decreasing Inappropriate Use of Rasburicase to Promote Cost-Effective Care.

J Oncol Pract 2019 Feb 23;15(2):e178-e186. Epub 2019 Jan 23.

1 University of Texas Southwestern Medical Center, Dallas, TX.

Background:: Rasburicase is a recommended treatment of tumor lysis syndrome and patients at high-risk for developing tumor lysis syndrome. Unfortunately, it is expensive, and unnecessary use raises costs of care.

Methods:: Plan, Do, Study, Act methodology was used to decrease the inappropriate use of rasburicase. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1200/JOP.18.00528DOI Listing
February 2019

Neurological Involvement in Childhood Evans Syndrome.

J Clin Immunol 2019 Jan 22. Epub 2019 Jan 22.

Centre de Référence National des Cytopénies Autoimmunes de l'Enfant (CEREVANCE), University Hospital of Bordeaux, Bordeaux, France.

Purpose: Immune thrombocytopenic purpura (ITP) and autoimmune hemolytic anemia (AIHA) are associated in the definition of Evans syndrome (ES). The occurrence of neurological involvement in this population is poorly described and suggests an underlying primary immunodeficiency (PID). We aimed to describe the clinical manifestations, evolution, and PID profiles of these patients. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s10875-019-0594-3
Publisher Site
http://dx.doi.org/10.1007/s10875-019-0594-3DOI Listing
January 2019
4 Reads

A case of autonomous cortisol secretion in a patient with subclinical Cushing's syndrome, GNAS mutation, and paradoxical cortisol response to dexamethasone.

BMC Endocr Disord 2019 Jan 22;19(1):13. Epub 2019 Jan 22.

Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: Increased urinary free cortisol in response to the oral administration of dexamethasone is a paradoxical reaction mainly reported in patients with primary pigmented nodular adrenocortical disease. Here, we describe the first case of subclinical Cushing's syndrome represented by autonomous cortisol secretion and paradoxical response to oral dexamethasone administration, harboring an activating mutation in the α subunit of the stimulatory G protein (GNAS).

Case Presentation: A 65-year-old woman was diagnosed with subclinical Cushing's syndrome during an evaluation for bilateral adrenal masses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12902-019-0345-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343241PMC
January 2019
1 Read

Awareness of consequences in agenesis of the corpus callosum: Semantic analysis of responses.

Neuropsychology 2019 Feb 21;33(2):275-284. Epub 2019 Jan 21.

Graduate School of Psychology, Travis Research Institute, Fuller Theological Seminary.

Objective: Agenesis of the corpus callosum (AgCC) in individuals with general intelligence within the normal range results in a syndrome of mild to moderate deficiencies in cognitive, emotional, and social functioning that are still being explored. Anecdotal accounts from families suggest that these cognitive and psychosocial deficiencies affect the ability of these individuals to anticipate the consequences of their decisions and behaviors. This research was designed to clarify the nature of social and emotional cognition in AgCC with respect to imagination of the consequences of decisions by assessing responses from the Awareness of Consequences Scale (AOCS). Read More

View Article

Download full-text PDF

Source
http://doi.apa.org/getdoi.cfm?doi=10.1037/neu0000512
Publisher Site
http://dx.doi.org/10.1037/neu0000512DOI Listing
February 2019
4 Reads

Are excess carbohydrates the main link to diabetes & its complications in Asians?

Indian J Med Res 2018 Nov;148(5):531-538

Department of Foods Nutrition & Dietetics Research, Madras Diabetes Research Foundation, Chennai, India.

Dietary carbohydrates form the major source of energy in Asian diets. The carbohydrate quantity and quality play a vital function in the prevention and management of diabetes. High glycaemic index foods elicit higher glycaemic and insulinaemic responses and promote insulin resistance and type 2 diabetes (T2D) through beta-cell exhaustion. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijmr.IJMR_1698_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366262PMC
November 2018
4 Reads

Berberine is a potential therapeutic agent for metabolic syndrome via brown adipose tissue activation and metabolism regulation.

Am J Transl Res 2018 15;10(11):3322-3329. Epub 2018 Nov 15.

Department of Radiology, Southwest Hospital, Third Military Medical University (Army Medical University) Chongqing, PR China.

Berberine (BBR), an isoquinoline alkaloid that derived from the Chinese medicinal plant Coptis chinensis, has been identified with multiple pharmacological activities, including regulating glucose and cholesterol levels, anti-obesity effects and anti-diabetic effects. Due to its multiple activities, BBR and its metabolites have drawn great attention in biomedical research and clinical practices. After the recent re-discovery of brown adipose tissue (BAT) in adult humans, stimulating energy-dissipating via BAT activation and white-to-brown adipose tissue conversion have been regarded as potential therapeutic strategies for obesity and diabetes. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291723PMC
November 2018
4 Reads

Periorbital pigmentation: An alarming sign of metabolic syndrome.

J Cosmet Dermatol 2019 Jan 20. Epub 2019 Jan 20.

Skin Diseases Center, Nashik, India.

Periorbital pigmentation is a commonly encountered condition which presents clinically as bilateral round, oval or semicircular homogenous dark brown pigmented macules in the periocular region. It may influence quality of life of an individual with its strong psychological impact. We present a case of middle-aged female patient, who had periorbital pigmentation as a manifestation of acanthosis nigricans. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/jocd.12852
Publisher Site
http://dx.doi.org/10.1111/jocd.12852DOI Listing
January 2019
4 Reads

Infratentorial immature teratoma of congenital origin can be associated with a 20-year survival outcome: a case report and review of literature.

World J Surg Oncol 2019 Jan 19;17(1):22. Epub 2019 Jan 19.

Division of Neurological Surgery, Department of Surgery, King Abdulaziz University Hospital, P.O. Box 80215, Jeddah, 21589, Kingdom of Saudi Arabia.

Background: Congenital intracranial tumors are very rare and account for less than 2% of all childhood brain tumors. Teratomas constitute about one third to one half of these, predominantly located midline in the supratentorial region. Posterior fossa location rarely occurs and, based on the cases reported in the literature, commonly has a poor prognosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12957-019-1564-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339688PMC
January 2019
3 Reads
1.200 Impact Factor