48,173 results match your criteria Brown Syndrome


Iliac Stent Migration to the Right Ventricular Outflow Tract.

Circ Cardiovasc Imaging 2018 Dec;11(12):e008520

Department of Radiology (M.T.C., M.L.S.), Brigham and Women's Hospital, Boston, MA.

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http://dx.doi.org/10.1161/CIRCIMAGING.118.008520DOI Listing
December 2018
1 Read

Management of non-missile penetrating spinal injury.

Neurosurg Rev 2018 Dec 18. Epub 2018 Dec 18.

Department of Neurosurgery, University of Utah School of Medicine, Salt Lake City, UT, USA.

Review of the literature with case illustration. Non-missile penetrating spinal injury (NPSI) represents a small subset of spinal cord injuries at tertiary trauma centers and is comprised mostly of knife violence. Strict guidelines for the management of penetrating spinal cord injury remain elusive given the variability of mechanisms, rarity of clinical experience, and paucity of prospective studies. Read More

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http://dx.doi.org/10.1007/s10143-018-01057-1DOI Listing
December 2018

Findings from aetiological investigation of Auditory Neuropathy Spectrum Disorder in children referred to cochlear implant programs.

Int J Pediatr Otorhinolaryngol 2019 Jan 11;116:79-83. Epub 2018 Oct 11.

Cochlear Implant Department, Great Ormond Street Hospital, London, United Kingdom. Electronic address:

Objectives: Auditory neuropathy spectrum disorder (ANSD) is an audiological diagnosis characterised by hearing dysfunction in the presence of intact outer hair cell function in the cochlea. ANSD is thought to account for 7-10% of all childhood permanent hearing impairment, and can result from a range of pathological processes. This paper describes the rationale, methods and findings from the aetiological investigation of ANSD. Read More

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http://dx.doi.org/10.1016/j.ijporl.2018.10.010DOI Listing
January 2019

Mutation screening of SLC52A3, C19orf12, and TARDBP in Iranian ALS patients.

Neurobiol Aging 2018 Nov 16. Epub 2018 Nov 16.

School of Biology, College of Science, University of Tehran, Tehran, Iran; Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran. Electronic address:

Mutations in the same gene are sometimes the cause of different clinically diagnosed neurologic disorders; this emphasizes interrelationships between various neurologic diseases. In this light, we screened SLC52A3, which is the cause of Brown-Vialetto-Van Laere syndrome, and C19orf12, which is the cause of neurodegeneration with brain iron accumulation in 60 Iranian amyotrophic lateral sclerosis (ALS) patients without mutations in the 2 most important ALS-causing genes, SOD1 and C9orf72. To the best of our knowledge, neither SLC52A3 nor C19orf12 has been mutation-screened previously in ALS cohorts. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2018.11.003DOI Listing
November 2018
1 Read

Brown adipose tissue thermogenesis in polycystic ovary syndrome.

Clin Endocrinol (Oxf) 2018 Dec 12. Epub 2018 Dec 12.

Department of Physiology, Monash University, Melbourne, Victoria, Australia.

Objective: Polycystic ovary syndrome (PCOS) is associated with increased obesity with a greater propensity to weight gain and a lack of sustainable lifestyle interventions. Altered brown adipose tissue (BAT) thermogenesis is a potential contributor to obesity in PCOS. BAT activity and modulation has not been studied in PCOS. Read More

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http://dx.doi.org/10.1111/cen.13913DOI Listing
December 2018
7 Reads

Addressing the empty pelvic syndrome following total pelvic exenteration: does mesh reconstruction help?

Colorectal Dis 2018 Dec 7. Epub 2018 Dec 7.

Department of Colorectal Surgery, Royal Prince Alfred Hospital, Sydney, Australia.

Aim: Perineal wound complications and pelvic abscesses remain a major source of morbidity after total pelvic exenteration. The void created in the pelvis after these multi-visceral resections leads to fluid accumulation and translocation of bowel within the pelvic cavity, which may increase the risk of pelvic abscess, perineal fluid discharge with perineal wound dehiscence and prolonged ileus. This study describes a novel technique using degradable synthetic mesh with overlying omentum to preclude small bowel and fill the empty space after total pelvic exenteration, and aimed to investigate the rate of pelvic abscess and perineal wound-related complications in this group. Read More

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http://dx.doi.org/10.1111/codi.14523DOI Listing
December 2018
2 Reads

Healthcare Providers' Perceived Communication Barriers to Offering Palliative Care to Patients With Heart Failure: An Integrative Review.

J Cardiovasc Nurs 2018 Dec 11. Epub 2018 Dec 11.

Marianne K. Schallmo, DNP, ANP-BC Clinical Assistant Professor of Nursing, School of Nursing, Purdue University Northwest, Hammond, Indiana. Sharon Dudley-Brown, PhD, FNP-BC, FAAN Associate Professor of Nursing, School of Nursing, University of Delaware, Newark. Patricia M. Davidson, PhD, MEd, BA, FAAN Dean of Nursing, School of Nursing, Johns Hopkins University, Baltimore, Maryland.

Context: Heart failure is a chronic complex syndrome that is common and burdensome. International clinical practice guidelines recommend that healthcare providers communicate palliative care options with patients with heart failure.

Objectives: The aim of this study was to conduct an integrative review to evaluate how healthcare providers perceived communication barriers to offering information to individuals in the palliative phase of heart failure. Read More

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http://dx.doi.org/10.1097/JCN.0000000000000556DOI Listing
December 2018

Effects of a high energy and low protein diet on hepatic and plasma characteristics and Cidea and Cidec mRNA expression in liver and adipose tissue of laying hens with fatty liver hemorrhagic syndrome.

Anim Sci J 2018 Dec 6. Epub 2018 Dec 6.

Jiangxi Provincial Key Laboratory for Animal Health, Institute of Animal Population Health, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang, China.

Cidea and Cidec are two members of Cell death-inducing DNA fragmentation factor-alpha-like effector family proteins, which could be involved in lipid or fat metabolism. To better understand the roles of Cidea and Cidec in fatty liver hemorrhagic syndrome (FLHS), 150 healthy 155-day-old Hyline Brown laying hens were randomly divided into control group (fed with basic diet) and experimental group (fed with high-energy low-protein [HELP] diet). Analysis of the liver by tissue sectioning and hematoxylin and eosin staining showed that the HELP diet induced micro-vesicular steatosis in laying hens. Read More

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http://dx.doi.org/10.1111/asj.13140DOI Listing
December 2018

A Renewable Source of Human Beige Adipocytes for Development of Therapies to Treat Metabolic Syndrome.

Cell Rep 2018 Dec;25(11):3215-3228.e9

Center for Molecular Medicine, Maine Medical Center Research Institute, 81 Research Drive, Scarborough, ME 04074, USA; School of Biomedical Sciences and Engineering, The University of Maine, Orono, ME 04469, USA; Tufts University School of Medicine, 145 Harrison Avenue, Boston, MA 02111, USA. Electronic address:

Molecular- and cellular-based therapies have the potential to reduce obesity-associated disease. In response to cold, beige adipocytes form in subcutaneous white adipose tissue and convert energy stored in metabolic substrates to heat, making them an attractive therapeutic target. We developed a robust method to generate a renewable source of human beige adipocytes from induced pluripotent stem cells (iPSCs). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22111247183180
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http://dx.doi.org/10.1016/j.celrep.2018.11.037DOI Listing
December 2018
2 Reads

Observational Study Examining the Association of Baseline Frailty and Postcardiac Surgery Delirium and Cognitive Change.

Anesth Analg 2018 Dec 11. Epub 2018 Dec 11.

Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland†Division of Medical Psychology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: Frailty is a geriatric syndrome thought to identify the most vulnerable older adults, and morbidity and mortality has been reported to be higher for frail patients after cardiac surgery compared to nonfrail patients. However, the cognitive consequences of frailty after cardiac surgery have not been well described. In this study, we examined the hypothesis that baseline frailty would be associated with postoperative delirium and cognitive change at 1 and 12 months after cardiac surgery. Read More

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http://dx.doi.org/10.1213/ANE.0000000000003967DOI Listing
December 2018
1 Read

Acute mesenteric ischaemia: A case of expedited diagnosis and management using point-of-care ultrasound.

Afr J Emerg Med 2018 Dec 2;8(4):164-166. Epub 2018 Oct 2.

Department of Emergency Medicine, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA.

Introduction: The term refers to a clinical syndrome of sudden onset, severe abdominal pain. The differential diagnosis for this presentation is broad, but most cases require emergent medical or surgical management. Especially in cases of ischaemic bowel, time to diagnosis can mean the difference between survival and death. Read More

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http://dx.doi.org/10.1016/j.afjem.2018.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277511PMC
December 2018
1 Read

First Complete Genome Sequence of a Hare Calicivirus Strain Isolated from .

Microbiol Resour Announc 2018 Dec 6;7(22). Epub 2018 Dec 6.

Avian and Rabbit Virology Immunology Parasitology Unit, Ploufragan-Plouzané-Niort Laboratory, French Agency for Food, Environmental and Occupational Health & Safety (Anses), Ploufragan, France.

The first full-genome sequence of a hare calicivirus (HaCV), recently characterized as a novel member of the , is described. This presumed nonpathogenic lagovirus is 7,433 nucleotides long, shows the same genomic organization as that of other lagoviruses, and has the highest nucleotide identity (79%) with pathogenic European brown hare syndrome viruses. Read More

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http://genomea.asm.org/lookup/doi/10.1128/MRA.01224-18
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http://dx.doi.org/10.1128/MRA.01224-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284081PMC
December 2018
5 Reads

Spinal cord injury without radiological abnormality (SCIWORA) manifested as self-limited brown-SEQUARD syndrome.

Trauma Case Rep 2018 Dec 26;18:28-30. Epub 2018 Nov 26.

Gadjah Mada University, Sardjito Hospital, Yogyakarta, Indonesia.

Introduction: Combination between SCIWORA and Brown-Sequard syndrome in a patient is a rare condition. In SCIWORA, there is usually a delay in neurologic deficits which can potentially lead to misdiagnosis. Therefore, the clinician should have a good understanding of the course of the disease to make a good diagnosis and treatment. Read More

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http://dx.doi.org/10.1016/j.tcr.2018.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260453PMC
December 2018

Minimal change disease: A case report.

Nursing 2018 Dec 10. Epub 2018 Dec 10.

At California State University, Chico, Fay Mitchell-Brown is an associate professor and Tiernan Veisze is a senior nursing student. Dr. Mitchell-Brown teaches pathophysiology and is a practicing critical care nurse.

Although minimal change disease (MCD) is a major cause of nephrotic syndrome in children, it's less common in adults. It develops from damage to the glomeruli with a loss of large amount of protein in the urine. Early recognition and treatment is the key to a good outcome. Read More

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http://dx.doi.org/10.1097/01.NURSE.0000549719.61573.cdDOI Listing
December 2018
1 Read

An interdomain bridge influences RNA binding of the human La protein.

J Biol Chem 2018 Dec 10. Epub 2018 Dec 10.

Biology, York University, Canada.

La proteins are RNA chaperones that perform various functions depending on distinct RNA-binding modes and their subcellular localization. In the nucleus, they help process UUU-3'OH-tailed nascent RNA polymerase III transcripts, such as pre-tRNAs, whereas in the cytoplasm they contribute to translation of poly(A)-tailed mRNAs. La accumulation in the nucleus and cytoplasm is controlled by several trafficking elements, including a canonical nuclear localization signal (NLS) in the extreme C terminus and a nuclear retention element (NRE) in the RNA recognition motif 2 (RRM2) domain. Read More

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http://dx.doi.org/10.1074/jbc.RA118.003995DOI Listing
December 2018
1 Read

Takotsubo syndrome: State-of-the-art review by an expert panel - Part 1.

Cardiovasc Revasc Med 2018 Nov 17. Epub 2018 Nov 17.

Section of Interventional Cardiology, MedStar Washington Hospital Center, Washington, DC, United States of America. Electronic address:

Takotsubo syndrome (TTS) is an acute cardiac condition independent of epicardial coronary obstruction that mimics acute coronary syndrome and is characterized by acute heart failure with reversible ventricular motion abnormalities. This consensus paper is the result of a multinational effort aiming to summarize the current state of the art on TTS. Experts in the field provide a thorough and detailed review of this syndrome. Read More

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http://dx.doi.org/10.1016/j.carrev.2018.11.015DOI Listing
November 2018

Whole genome variant association across 100 dogs identifies a frame shift mutation in DISHEVELLED 2 which contributes to Robinow-like syndrome in Bulldogs and related screw tail dog breeds.

PLoS Genet 2018 Dec 6;14(12):e1007850. Epub 2018 Dec 6.

Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, CA, United States of America.

Domestic dog breeds exhibit remarkable morphological variations that result from centuries of artificial selection and breeding. Identifying the genetic changes that contribute to these variations could provide critical insights into the molecular basis of tissue and organismal morphogenesis. Bulldogs, French Bulldogs and Boston Terriers share many morphological and disease-predisposition traits, including brachycephalic skull morphology, widely set eyes and short stature. Read More

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http://dx.plos.org/10.1371/journal.pgen.1007850
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http://dx.doi.org/10.1371/journal.pgen.1007850DOI Listing
December 2018
8 Reads

Total knee arthroplasty in a patient with nail-patella syndrome (NPS).

Knee 2018 Nov 29. Epub 2018 Nov 29.

Houston Methodist Othopedics & Sports Medicine, Houston, TX, United States of America. Electronic address:

Nail-patella syndrome (NPS) or hereditary onycho-osteodyaplasia is a rare genetic condition involving a mutation in the LMX1B gene affecting nails, elbows, knees, and pelvis. Due to the regulatory functions of the gene in many developmental processes through the body, patients with NPS experience wide-ranging musculoskeletal problems including patellar instability, fingernail anomalies, iliac exostoses/horns, and elbow abnormalities. The patellar changes often involve aplasia, hypoplasia, and chronic dislocation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09680160183094
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http://dx.doi.org/10.1016/j.knee.2018.11.014DOI Listing
November 2018
4 Reads

Novel Strategy of Ventral Dural Repair for Idiopathic Thoracic Spinal Cord Herniation: Report of Outcomes and Review of Techniques.

Oper Neurosurg (Hagerstown) 2018 Dec 4. Epub 2018 Dec 4.

Department of Neurosurgery, Cleveland Clinic, Cleveland, Ohio.

Background: Idiopathic ventral thoracic spinal cord herniation is a rare condition that usually presents with progressive myelopathy or Brown-Séquard syndrome. More than 100 cases have been reported with significant variance in surgical treatment strategies and likewise, significant variance in patient outcomes. Although laminectomy has often been used, to date, there is no consensus regarding the optimal surgical approach or strategy for ventral dural repair. Read More

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http://dx.doi.org/10.1093/ons/opy244DOI Listing
December 2018
2 Reads

Prenatal cell-free DNA screening test failures: a systematic review of failure rates, risks of Down syndrome, and impact of repeat testing.

Genet Med 2018 11 26;20(11):1312-1323. Epub 2018 Apr 26.

Department of Pathology and Laboratory Medicine, Women and Infants Hospital, Providence, Rhode Island, USA.

Purpose: We systematically reviewed the published literature on test failure rates for the sequencing of cell-free DNA (cfDNA) in maternal plasma to identify Down syndrome.

Methods: We searched peer-reviewed English publications with diagnostic results on all pregnancies that provided test failure rates. Data on the odds of failure in Down syndrome and euploid pregnancies and the impact of repeat testing were extracted. Read More

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http://dx.doi.org/10.1038/gim.2018.22DOI Listing
November 2018
1 Read

Low plasma haptoglobin is a risk factor for life-threatening childhood severe malarial anemia and not an exclusive consequence of hemolysis.

Sci Rep 2018 Dec 3;8(1):17527. Epub 2018 Dec 3.

Department of Paediatrics, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria.

Severe Malarial Anemia (SMA), a life-threatening childhood Plasmodium falciparum malaria syndrome requiring urgent blood transfusion, exhibits inflammatory and hemolytic pathology. Differentiating between hypo-haptoglobinemia due to hemolysis or that of genetic origin is key to understand SMA pathogenesis. We hypothesized that while malaria-induced hypo-haptoglobinemia should reverse at recovery, that of genetic etiology should not. Read More

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http://dx.doi.org/10.1038/s41598-018-35944-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277387PMC
December 2018
1 Read

Diagnosis and Management of Hip Abductor Insufficiency.

R I Med J (2013) 2018 Dec 3;101(10):46-50. Epub 2018 Dec 3.

Division of Sports Medicine, Department of Orthopaedic Surgery, Warren Alpert Medical School, Brown University.

Greater Trochanteric Pain Syndrome (GTPS) is a common cause of lateral hip pain, with an incidence of 1.8 per 1000 patients, most commonly occurring between the fourth and sixth decades of life. When GTPS fails to improve with conservative management, hip abductor insufficiency should be suspected. Read More

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December 2018
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POEMS syndrome: clinical update.

J Neurol 2018 Nov 29. Epub 2018 Nov 29.

Department of Neurology, Royal Free Hospital, Pond Street, London, NW3 2QG, UK.

POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M-protein, skin changes) is a rare paraneoplastic syndrome, caused by a plasma cell proliferative disorder, which is most commonly lambda restricted. The neurological hallmark, which forms one of the mandatory criteria for diagnosis, is a subacute onset demyelinating neuropathy, which can be rapidly disabling and painful. A number of multi-system features are also characteristic of this disorder, and certainly not restricted to those included in its acronym, which though limited, remains a useful and memorable name, helping distinguish POEMS syndrome from other paraproteinaemic neuropathies. Read More

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http://link.springer.com/10.1007/s00415-018-9110-6
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http://dx.doi.org/10.1007/s00415-018-9110-6DOI Listing
November 2018
3 Reads

Response of the popliteal artery to treadmill exercise and stress positioning in patients with and without exertional lower extremity symptoms.

J Vasc Surg 2018 Nov 26. Epub 2018 Nov 26.

Vascular Surgery Service, San Antonio Military Medical Center, Fort Sam Houston, Tex; Department of Surgery, Uniformed Services University, Bethesda, Md. Electronic address:

Objective: Functionally limiting exertional lower extremity pain and neurologic symptoms are commonly encountered in military and civilian settings. Exertional muscle compression of the popliteal artery (PA) and tibial nerve in the proximal calf (the "popliteal outlet") can be associated with these symptoms but is rarely investigated as a cause. Exertional ankle-brachial index (EABI) and dynamic PA ultrasound imaging may be suitable to screen for this syndrome of "functional" popliteal entrapment, but neither has been rigorously studied. Read More

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http://dx.doi.org/10.1016/j.jvs.2018.08.171DOI Listing
November 2018
1 Read

Deep brain stimulation for Gilles de la Tourette syndrome in children and youth: a meta-analysis with individual participant data.

Authors:

J Neurosurg Pediatr 2018 Oct 1:1-11. Epub 2018 Oct 1.

OBJECTIVEGilles de la Tourette syndrome (GTS) is a disorder characterized by motor and vocal tics. Although by definition the onset of GTS is before age 18 years, clinical trials of deep brain stimulation (DBS) have been conducted only in adults. Using individual participant data (IPD) meta-analysis methodology, the current study investigated the safety and efficacy of DBS as a treatment for GTS in children and youth. Read More

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http://dx.doi.org/10.3171/2018.7.PEDS18300DOI Listing
October 2018
1 Read

International Stakeholder Community of Pain Experts and Leaders Call for an Urgent Action on Forced Opioid Tapering.

Authors:
Beth D Darnall David Juurlink Robert D Kerns Sean Mackey Brent Van Dorsten Keith Humphreys Julio A Gonzalez-Sotomayor Andrea Furlan Adam J Gordon Debra B Gordon Diane E Hoffman Joel Katz Stefan G Kertesz Sally Satel Richard A Lawhern Kate M Nicholson Rosemary C Polomano Owen D Williamson Heath McAnally Ming-Chih Kao Stephan Schug Robert Twillman Terri A Lewis Richard L Stieg Kate Lorig Theresa Mallick-Searle Robert W West Sarah Gray Steven R Ariens Jennifer Sharpe Potter Penney Cowan Chad D Kollas Danial Laird Barby Ingle J Julian Grove Marian Wilson Kashelle Lockman Fiona Hodson Carol S Palackdharry Roger B Fillingim Jeffrey Fudin Jennifer Barnhouse Ajay Manhapra Steven R Henson Bruce Singer Marie Ljosenvoor Marlisa Griffith Jason N Doctor Kimeron Hardin Cathleen London Jon Mankowski Andrea Anderson Linda Ellsworth Lisa Davis Budzinski Becky Brandt Greg Harkootley Debbie Nickels Heck Mark J Zobrosky Celeste Cheek Megan Wilson Cynthia E Laux Geralyn Datz Justin Dunaway Eileen Schonfeld Melissa Cady Thérèse LeDantec-Boswell Meredith Craigie John Sturgeon Pamela Flood Melita Giummarra Jessica Whelan Beverly E Thorn Richard L Martin Michael E Schatman Maurice D Gregory Joshua Kirz Patti Robinson James G Marx Jessica R Stewart Phillip S Keck Scott E Hadland Jennifer L Murphy Mark A Lumley Kathleen S Brown Michael S Leong Mechele Fillman James W Broatch Aaron Perez Kristine Watford Kari Kruska Dokyoung Sophia You Stacy Ogbeide Amy Kukucka Susan Lawson James B Ray T Wade Martin James B Lakehomer Anne Burke Robert I Cohen Peter Grinspoon Marc S Rubenstein Stephani Sutherland Kristie Walters Travis Lovejoy

Pain Med 2018 Nov 29. Epub 2018 Nov 29.

Department of Psychiatry, Oregon Health & Science University, Portland, Oregon.

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/pm/pny228DOI Listing
November 2018
3 Reads
2.300 Impact Factor

Expression enhancement in brown adipose tissue of genes related to thermogenesis and mitochondrial dynamics after administration of pepsin egg white hydrolysate.

Food Funct 2018 Dec;9(12):6599-6607

Instituto de Investigación en Ciencias de la Alimentación (CIAL, CSIC-UAM), Madrid, Spain.

Nutritional compounds could be a safe and less expensive treatment for complications associated with obesity and metabolic syndrome (MetS). The aim of this study was to investigate the mechanism of action and the target tissues of a pepsin egg white hydrolysate (EWH) which had previously been demonstrated to improve some obesity-related disorders on a high-fat/high-glucose rat model. Wistar rats were used and divided into 3 groups: Control group (C), High-fat/high-glucose diet (MS) and high-fat/high-glucose diet + EWH (MSH). Read More

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http://dx.doi.org/10.1039/c8fo01754aDOI Listing
December 2018
1 Read

A rare case of Brown-Sequard syndrome caused by traumatic cervical epidural hematoma.

Surg Neurol Int 2018 23;9:213. Epub 2018 Oct 23.

Department of Neurosurgery, Riverside University Health System, Riverside, California, USA.

Background: Brown-Sequard syndrome (BSS) is a well-known entity that is most commonly caused by a penetrating injury to the spinal cord (e.g., stab wound or gunshot wound). Read More

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http://www.surgicalneurologyint.com/text.asp?2018/9/1/213/24
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http://dx.doi.org/10.4103/sni.sni_142_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213806PMC
October 2018
3 Reads

An avian influenza virus H6N1 outbreak in commercial layers: case report and reproduction of the disease.

Avian Pathol 2018 Nov 28:1-35. Epub 2018 Nov 28.

a GD - Animal Health , Arnsbergstraat 7, 7418 EZ , Deventer , the Netherlands.

An outbreak of low pathogenic avian influenza (LPAI) subtype H6N1 (intravenous pathogenicity index = 0.11) infection occurred in four productive brown layer flocks on three farms in the Netherlands within a period of two months. The farms were located at a maximum distance of 4. Read More

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http://dx.doi.org/10.1080/03079457.2018.1551612DOI Listing
November 2018
1 Read

Examination of Current Treatments and Symptom Management Strategies Used by Patients With Mal De Debarquement Syndrome.

Front Neurol 2018 12;9:943. Epub 2018 Nov 12.

School of Science and Health, Western Sydney University, Sydney, NSW, Australia.

Mal de Debarquement Syndrome (MdDS) is a neurological disorder which affects the vestibular system pathways, manifesting as a constant sensation of movement in the form of rocking, bobbing, or swaying. The mechanism of MdDS is poorly understood and there is a lack of awareness amongst medical professionals about the condition. This study aimed to examine treatments and symptom management strategies used by MdDS patients and evaluate their self-reported effectiveness. Read More

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https://www.frontiersin.org/article/10.3389/fneur.2018.00943
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http://dx.doi.org/10.3389/fneur.2018.00943DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240763PMC
November 2018
5 Reads

Overcoming species barriers: an outbreak of Lagovirus europaeus GI.2/RHDV2 in an isolated population of mountain hares (Lepus timidus).

BMC Vet Res 2018 Nov 26;14(1):367. Epub 2018 Nov 26.

Department of Pathology and Wildlife Diseases, National Veterinary Institute (SVA), 751 89, Uppsala, Sweden.

Background: Prior to 2010, the lagoviruses that cause rabbit hemorrhagic disease (RHD) in European rabbits (Oryctolagus cuniculus) and European brown hare syndrome (EBHS) in hares (Lepus spp.) were generally genus-specific. However, in 2010, rabbit hemorrhagic disease virus 2 (RHDV2), also known as Lagovirus europaeus GI. Read More

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https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-
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http://dx.doi.org/10.1186/s12917-018-1694-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258167PMC
November 2018
4 Reads

Prolonged intake of desloratadine: mesenteric lymphatic vessel dysfunction and development of obesity/metabolic syndrome.

Am J Physiol Gastrointest Liver Physiol 2018 Nov 26. Epub 2018 Nov 26.

Department of Medical Physiology, Texas A&M University Health Science Center College of Medicine, United States.

This study aimed to establish mechanistic links between the prolonged intake of desloratadine, a common H1 receptor blocker (i.e. antihistamine), and development of obesity and metabolic syndrome. Read More

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https://www.physiology.org/doi/10.1152/ajpgi.00321.2018
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http://dx.doi.org/10.1152/ajpgi.00321.2018DOI Listing
November 2018
7 Reads

Pregnancy after Aortic Root Replacement in Marfan's Syndrome: A Case Series and Review of the Literature.

AJP Rep 2018 Oct 18;8(4):e234-e240. Epub 2018 Oct 18.

Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.

 We sought to characterize pregnancy-related aortic complications in women with Marfan's syndrome who had prior aortic root replacement.  This is a retrospective case series study and literature review of women with Marfan's syndrome with pregnancy after aortic root replacement. We surveyed women with Marfan's syndrome who had successful pregnancy after aortic root replacement using the Marfan Foundation Website and from two large tertiary care Marfan's clinics. Read More

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http://dx.doi.org/10.1055/s-0038-1675347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193806PMC
October 2018
1 Read

Quantum Error Correction Decoheres Noise.

Phys Rev Lett 2018 Nov;121(19):190501

Institute for Quantum Computing and Department of Physics and Astronomy, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada.

Typical studies of quantum error correction assume probabilistic Pauli noise, largely because it is relatively easy to analyze and simulate. Consequently, the effective logical noise due to physically realistic coherent errors is relatively unknown. Here, we prove that encoding a system in a stabilizer code and measuring error syndromes decoheres errors, that is, causes coherent errors to converge toward probabilistic Pauli errors, even when no recovery operations are applied. Read More

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http://dx.doi.org/10.1103/PhysRevLett.121.190501DOI Listing
November 2018
2 Reads

Neonatal abstinence syndrome.

Nat Rev Dis Primers 2018 Nov 22;4(1):47. Epub 2018 Nov 22.

Department of Obstetrics and Gynecology, University of North Carolina, Carrboro, NC, USA.

Neonatal abstinence syndrome refers to the signs and symptoms attributed to the cessation of prenatal exposure (via placental transfer) to various substances. This Primer focuses on neonatal abstinence syndrome caused by opioid use during pregnancy - neonatal opioid withdrawal syndrome (NOWS). As the global prevalence of opioid use has alarmingly increased, so has the incidence of NOWS. Read More

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http://dx.doi.org/10.1038/s41572-018-0045-0DOI Listing
November 2018

Optimal cut-off for obesity and markers of metabolic syndrome for Ethiopian adults.

Nutr J 2018 Nov 22;17(1):109. Epub 2018 Nov 22.

Human Nutrition Unit, Faculty of public Health, Jimma University, PO.BOX: 378, Jimma, Southwest, Ethiopia.

Background: Metabolic syndrome (MetS) is defined as the presence of central obesity plus any two of the following markers: high triglycerides (> 150 mg/dl), low high density lipoprotein (HDL) cholesterol < 40 mg/dl in men and < 50 mg/dl in women, hypertension (blood pressure > 130/85 mmHg or use of antihypertensive medication), high fasting blood glucose (> 100 mg/dl or use of treatment for diabetes mellitus). Since recently, metabolic syndrome and obesity have become emerging problems of both low and middle income countries, although they have been the leading cause of morbidity and mortality in high income countries for the past decades. It has been indicated that the international anthropometric cut-off for detecting obesity is not appropriate for Ethiopians. Read More

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http://dx.doi.org/10.1186/s12937-018-0416-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251157PMC
November 2018
5 Reads

Inter-tissue communication in cancer cachexia.

Nat Rev Endocrinol 2018 Dec;15(1):9-20

Cancer Research Group, Departament de Bioquímica i Biomedicina Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.

Cachexia is a systemic condition that occurs during many neoplastic diseases, such as cancer. Cachexia in cancer is characterized by loss of body weight and muscle and by adipose tissue wasting and systemic inflammation. Cancer cachexia is often associated with anorexia and increased energy expenditure. Read More

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http://dx.doi.org/10.1038/s41574-018-0123-0DOI Listing
December 2018
3 Reads

Nausea in the peri-traumatic period is associated with prospective risk for PTSD symptom development.

Neuropsychopharmacology 2018 Nov 21. Epub 2018 Nov 21.

Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.

While nausea often develops following exposure to trauma, little is known regarding the relationship between peri-traumatic nausea and prospective risk for developing posttraumatic stress disorder (PTSD). We examined the association between peri-traumatic nausea and PTSD symptom development in three independent cohorts. Participants were recruited from (1) the Emergency Departments (ED) at Grady Memorial Hospital (GMH) in Atlanta, GA, (2) from multiple other ED sites in the TRYUMPH Research Network, and (3) from the ED during evaluation for suspected acute coronary syndrome in the REACH cohort. Read More

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http://dx.doi.org/10.1038/s41386-018-0276-5DOI Listing
November 2018
4 Reads

Evidence-based update on the surgical treatment of pediatric tibial shaft fractures.

Curr Opin Pediatr 2018 Nov 15. Epub 2018 Nov 15.

Pediatric Orthopaedic Surgery Service, Hospital for Special Surgery, Weill Cornell Medical College, New York, New York, USA.

Purpose Of Review: To describe surgical treatment options for pediatric tibial shaft fractures which are the third most common pediatric long bone fracture. Management of these injuries is dictated by fracture location, fracture pattern, associated injuries, skeletal maturity, and other patient-specific factors. Although most pediatric tibial shaft fractures can be treated nonoperatively, this review provides an update on surgical treatment options when operative intervention is indicated. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000704DOI Listing
November 2018
3 Reads

Self-reported infertility, metabolic dysfunction, and cardiovascular events: a cross-sectional analysis among U.S. women.

Fertil Steril 2018 Nov 17. Epub 2018 Nov 17.

Maternal & Child Health Program, Department of Family Science, School of Public Health, University of Maryland, College Park, Maryland.

Objective: To explore associations between infertility and metabolic syndrome, and cardiovascular events. Infertility is increasingly a public health issue, with emerging links to chronic disease. Existing literature on infertility focuses primarily on known causes, which likely excludes a substantial number of women for whom there is no known cause or formal diagnosis. Read More

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http://dx.doi.org/10.1016/j.fertnstert.2018.10.009DOI Listing
November 2018
2 Reads

No effect of unacylated ghrelin administration on subcutaneous PC3 xenograft growth or metabolic parameters in a Rag1-/- mouse model of metabolic dysfunction.

PLoS One 2018 20;13(11):e0198495. Epub 2018 Nov 20.

Ghrelin Research Group, Translational Research Institute - Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.

Ghrelin is a peptide hormone which, when acylated, regulates appetite, energy balance and a range of other biological processes. Ghrelin predominately circulates in its unacylated form (unacylated ghrelin; UAG). UAG has a number of functions independent of acylated ghrelin, including modulation of metabolic parameters and cancer progression. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198495PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245673PMC
November 2018
7 Reads

Duodenal Schwannoma as a Rare Association With Membranous Nephropathy: A Case Report.

Am J Kidney Dis 2018 Nov 16. Epub 2018 Nov 16.

Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, HI.

Membranous nephropathy (MN) associated with malignancies is a well-known entity. However, its association with benign neoplasm is not broadly recognized. A 69-year-old man with recurrent nephrotic syndrome presented with pedal edema and proteinuria of 5 months' duration. Read More

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http://dx.doi.org/10.1053/j.ajkd.2018.09.003DOI Listing
November 2018
6 Reads

Microbleeds and Cerebral Amyloid Angiopathy in the Brains of People with Down Syndrome with Alzheimer's Disease.

J Alzheimers Dis 2018 Nov 15. Epub 2018 Nov 15.

Sanders Brown Center on Aging, University of Kentucky, Lexington, KY, USA.

Cerebrovascular pathology is a significant mediator in Alzheimer's disease (AD) in the general population. In people with Down syndrome (DS), the contribution of vascular pathology to dementia may play a similar role in age of onset and/or the rate of progression of AD. In the current study, we explored the extent of microbleeds (MBs) and the link between cerebral amyloid angiopathy (CAA) and MBs in the frontal cortex (FCTX) and occipital cortex (OCTX) in an autopsy series from individuals with DS (<40 years), DS with AD pathology (DSAD), sporadic AD, and control cases (2-83 years). Read More

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http://dx.doi.org/10.3233/JAD-180589DOI Listing
November 2018
3 Reads

Analyses of LMNA-negative juvenile progeroid cases confirms biallelic POLR3A mutations in Wiedemann-Rautenstrauch-like syndrome and expands the phenotypic spectrum of PYCR1 mutations.

Hum Genet 2018 Dec 19;137(11-12):921-939. Epub 2018 Nov 19.

Warren Alpert Medical School of Brown University, Providence, RI, USA.

Juvenile segmental progeroid syndromes are rare, heterogeneous disorders characterized by signs of premature aging affecting more than one tissue or organ starting in childhood. Hutchinson-Gilford progeria syndrome (HGPS), caused by a recurrent de novo synonymous LMNA mutation resulting in aberrant splicing and generation of a mutant product called progerin, is a prototypical example of such disorders. Here, we performed a joint collaborative study using massively parallel sequencing and targeted Sanger sequencing, aimed at delineating the underlying genetic cause of 14 previously undiagnosed, clinically heterogeneous, non-LMNA-associated juvenile progeroid patients. Read More

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http://dx.doi.org/10.1007/s00439-018-1957-1DOI Listing
December 2018
3 Reads
4.824 Impact Factor

Knock-in of the R394W mutation causes MDS and cooperates with to drive aggressive myeloid neoplasms in mice.

Oncotarget 2018 Oct 19;9(82):35313-35326. Epub 2018 Oct 19.

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Wilms tumor 1 (WT1) is a zinc finger transcriptional regulator, and has been implicated as both a tumor suppressor and oncogene in various malignancies. Mutations in the DNA-binding domain of the gene are described in 10-15% of normal-karyotype AML (NK-AML) in pediatric and adult patients. Similar mutations have been reported in adult patients with myelodysplastic syndrome (MDS). Read More

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http://www.oncotarget.com/fulltext/26238
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http://dx.doi.org/10.18632/oncotarget.26238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219680PMC
October 2018
3 Reads
6.359 Impact Factor

Retinal astrocytoma in a young male with PTEN hamartoma tumor syndrome.

J AAPOS 2018 Nov 14. Epub 2018 Nov 14.

Division of Ophthalmology, Warren Alpert Medical School, Brown University, Providence, Rhode Island.

We present the novel finding of retinal astrocytoma in a 15-year-old boy with phosphatase and tensin homologue hamartoma tumor syndrome, confirmed by genetic testing. Read More

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http://dx.doi.org/10.1016/j.jaapos.2018.07.357DOI Listing
November 2018
2 Reads

Poractant Alfa Versus Beractant for Neonatal Respiratory Distress Syndrome: A Retrospective Cost Analysis.

J Pediatr Pharmacol Ther 2018 Sep-Oct;23(5):367-371

Objectives: The objectives of this study were to determine the average medication cost per patient of poractant alfa and beractant, and to compare the outcomes of treatment with these agents.

Methods: We conducted a retrospective, observational, cohort study of patients who received surfactant, before and after an institutional formulary change from beractant to poractant alfa. The primary outcome was the average medication cost per case. Read More

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http://www.jppt.org/doi/10.5863/1551-6776-23.5.367
Publisher Site
http://dx.doi.org/10.5863/1551-6776-23.5.367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6213622PMC
November 2018
6 Reads

Uncoupling protein-1 deficiency promotes brown adipose tissue inflammation and ER stress.

PLoS One 2018 14;13(11):e0205726. Epub 2018 Nov 14.

Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.

Inflammation and endoplasmic reticulum (ER) stress are hallmarks of metabolic syndrome. While these metabolic derangements have been well-investigated in white adipose tissue, their existence and etiology in brown adipose tissue (BAT) are poorly understood. Here, we aimed to investigate ER homeostasis and the inflammatory status and of BAT lacking uncoupling protein-1 (UCP1), a protein required for BAT thermogenesis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205726PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6235278PMC
November 2018
7 Reads

Molecular identification of Betacoronavirus in bats from Sardinia (Italy): first detection and phylogeny.

Virus Genes 2018 Nov 13. Epub 2018 Nov 13.

Department of Veterinary Medicine, University of Sassari, Via Vienna 2, 07100, Sassari, Italy.

Bats may be natural reservoirs for a large variety of emerging viruses, including mammalian coronaviruses (CoV). The recent emergence of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) in humans, with evidence that these viruses may have their ancestry in bats, highlights the importance of virus surveillance in bat populations. Here, we report the identification and molecular characterization of a bat β-Coronavirus, detected during a viral survey carried out on different bat species in the island of Sardinia (Italy). Read More

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http://dx.doi.org/10.1007/s11262-018-1614-8DOI Listing
November 2018
1 Read