54,723 results match your criteria Brown Syndrome


Multisystem Inflammatory Syndrome in an Adolescent Following SARS-CoV-2 Exposure Despite Three Doses of a COVID-19 Vaccine.

R I Med J (2013) 2022 Jun 1;105(5):41-45. Epub 2022 Jun 1.

Division of Pediatric Rheumatology, Department of Pediatrics, Warren Alpert Medical School of Brown University, Providence, RI.

The multisystem inflammatory syndrome in children (MIS-C) is a known complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the pediatric population. Recent studies have demonstrated high efficacy of a two-dose vaccine series in preventing MIS-C among adolescents. To date, such studies have only included children exposed to SARS-CoV-2 prior to the emergence of the Omicron variant (B. Read More

View Article and Full-Text PDF

An epidemiologic analysis of the association between eyelid disorders and ocular motility disorders in pediatric age.

Sci Rep 2022 May 25;12(1):8840. Epub 2022 May 25.

Ophthalmology Unit, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Aim of the study was to assess: (a) the prevalence and type of strabismus, ptosis and eyelid dynamic disorders features, (b) the prevalence of refractive errors, amblyopia and, (c) their association with ocular/systemic syndromes in a cohort of patients. This is a retrospective observational multicenter cohort study. Patients with coexisting ocular motility disorders, comitant and incomitant strabismus, ptosis and dynamic eyelid disorders who have never undergone surgery were enrolled throughout a 3-years a study period. Read More

View Article and Full-Text PDF

Risk of Hematologic Cancer in Patients With Undifferentiated Pruritus.

JAMA Dermatol 2022 May 25. Epub 2022 May 25.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Importance: Although pruritus is common in patients with hematologic cancers, it is unknown whether patients with undifferentiated pruritus have higher risk of developing hematologic cancer. Furthermore, it is unclear whether serum lactate dehydrogenase (LDH) level, commonly ordered for cancer workup, has diagnostic utility in patients with pruritus.

Objective: To assess the risk of hematologic cancer and the diagnostic utility of LDH level in patients with undifferentiated pruritus. Read More

View Article and Full-Text PDF

Non-ocular risk factors in Turkish children with strabismus and amblyopia.

Turk J Pediatr 2022 ;64(2):341-349

Department of Ophthalmology, Sakarya University Medical Education and Research Hospital, Sakarya, Turkey.

Background: To evaluate non-ocular risk factors including family history, febrile seizure, history of trauma, neurological diseases, and prematurity in Turkish children with strabismus and amblyopia.

Methods: The records of patients diagnosed with strabismus and/or amblyopia below 18 years old, were recruited. The current mean age, sex, types and subtypes of strabismus and amblyopia, family history, history of trauma, and febrile seizure were investigated. Read More

View Article and Full-Text PDF

Etiology-based strabismus classification scheme for pediatricians.

Turk J Pediatr 2022 ;64(2):332-340

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL.

Background: Pediatricians are regularly involved in the initial examination of children presenting with strabismus, a common ocular condition occurring in 3% of children. The objective of this review was to gain insight into pediatric residents, fellows and attendings` understanding of strabismus, and to propose an etiology-based strabismus classification scheme to aid this understanding.

Methods: A survey was conducted in a single Department of Pediatrics in a university academic institution in order to assess the degree of understanding of the classification, etiology and nomenclature of strabismus. Read More

View Article and Full-Text PDF

Genetic analysis assists diagnosis of clinical systemic disease in children with excessive hyperopia.

BMC Pediatr 2022 May 24;22(1):305. Epub 2022 May 24.

Eye Center of Xiangya Hospital, Hunan Key Laboratory of Ophthalmology, Central South University, Changsha, Hunan Province, China.

Background: A thorough examination (especially those including visual functional evaluation) is very important in children's eye-development during clinical practice, when they encountered with unusual excessive hyperopia especially accompanied with other possible complications. Genetic testing would be beneficial for early differential diagnosis as blood sampling is more convenient than all other structural imaging capture tests or functional tests which need children to cooperate well. Thus genetic testing helps us to filter other possible multi-systemic diseases in children patients with eye disorder. Read More

View Article and Full-Text PDF

Miller Fisher syndrome after COVID-19 vaccination: Case report and review of literature.

Medicine (Baltimore) 2022 May 20;101(20):e29333. Epub 2022 May 20.

Hamad Medical Corporation, Doha, Qatar.

Rationale: Miller Fisher syndrome (MFS) is a rare variant of Guillain-Barre syndrome, classically diagnosed based on the clinical triad of ataxia, areflexia, and ophthalmoplegia. MFS is usually preceded by viral infections and febrile illness; however, only a few cases have been reported after vaccinations.

Patient Concerns: A 53-year-old hypertensive male presented with a 2-day history of progressive ascending paralysis of the lower limbs along with diplopia and ataxia, 8 days after the first dose of the Sinovac-Coronavac coronavirus disease 2019 (COVID-19) vaccination, with no prior history of any predisposing infections or triggers. Read More

View Article and Full-Text PDF

A multisystem, cardio-renal investigation of post-COVID-19 illness.

Nat Med 2022 May 23. Epub 2022 May 23.

Department of Cardiology, University Hospital Crosshouse, Kilmarnock, UK.

The pathophysiology and trajectory of post-Coronavirus Disease 2019 (COVID-19) syndrome is uncertain. To clarify multisystem involvement, we undertook a prospective cohort study including patients who had been hospitalized with COVID-19 (ClinicalTrials.gov ID NCT04403607 ). Read More

View Article and Full-Text PDF

Cutaneous Toxicities Associated with Immune Checkpoint Inhibitors: an Observational, Pharmacovigilance Study.

J Invest Dermatol 2022 May 18. Epub 2022 May 18.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, Baltimore, MD. Electronic address:

Cutaneous immune-related adverse events (cirAEs) are the most prevalent complication to arise from immunotherapy and cause significant morbidity. We aimed to determine the spectrum, timing, clinical features, and outcomes of cirAEs by conducting an observational pharmacovigilance study using VigiBase, the World Health Organization's global database of individual case safety reports from over 130 member countries (ClinicalTrials.gov, number NCT04898751). Read More

View Article and Full-Text PDF

Treatment initiation and utilization patterns of pharmacotherapies for early-onset idiopathic restless legs syndrome.

Sleep Med 2022 May 13;96:70-78. Epub 2022 May 13.

Department of Pharmaceutical Outcomes & Policy, University of Florida, College of Pharmacy, 1225 Center Drive, Gainesville, FL, 32610-0496, USA; Center for Drug Evaluation & Safety, Department of Pharmaceutical Outcomes & Policy, University of Florida, College of Pharmacy, 1225 Center Drive, Gainesville, FL, 32610-0496, USA. Electronic address:

Objective/background: Restless legs syndrome (RLS) is a complex condition associated with circadian rhythm that disrupts sleep and can cause multisystemic consequences. This study assesses pharmacotherapy treatment initiation, estimates annual treatment prevalence, and assesses treatment patterns for early-onset idiopathic RLS.

Methods: We used the MarketScan Commercial Claims Database from 2012 to 2019 to conduct a new user retrospective cohort study. Read More

View Article and Full-Text PDF

A Case of Recurrent Acute Pancreatitis Secondary to Hypertriglyceridemia.

Cureus 2022 Apr 17;14(4):e24223. Epub 2022 Apr 17.

Hospital Medicine, Franciscan Health, Lafayette, USA.

Hypertriglyceridemia is known to be the third most common etiology of acute pancreatitis. Triglyceride levels above 1,000 mg/dL are associated with an increased risk of acute pancreatitis. We present the case of a 22-year-old female, a known case of hypertriglyceridemia, who developed sudden onset severe epigastric abdominal pain. Read More

View Article and Full-Text PDF

Effect of bilateral inferior oblique partial myectomy on V pattern exotropia with inferior oblique overaction.

BMC Ophthalmol 2022 May 21;22(1):230. Epub 2022 May 21.

Department of Ophthalmology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, China.

Purpose: To compare the effect of bilateral inferior oblique partial myectomy on V-pattern exotropia patients with bilateral symmetric inferior oblique overaction (IOOA) and asymmetric IOOA.

Methods: This was a retrospective study including 53 V-pattern exotropia patients with bilateral IOOA of all grades who underwent bilateral inferior oblique partial myectomy. Success was defined as the elimination of the IOOA and the collapse of the V pattern at the final follow-up. Read More

View Article and Full-Text PDF

Surgical outcomes of unilateral lateral rectus recession versus recess-resect in children with convergence insufficiency type intermittent exotropia.

Sci Rep 2022 May 21;12(1):8591. Epub 2022 May 21.

Department of Ophthalmology, Kangnam Sacred Heart Hospital, Hallym University College of Medicine, 665 Shiheongdae-ro, Seoul, 07442, South Korea.

To determine the efficacy of unilateral lateral rectus recession (ULR) for convergence insufficiency-type intermittent exotropia (CI-type IXT), we compared surgical outcomes following ULR and recess‒resect (RR) procedures for CI-type IXT. In this retrospective study, medical records of 57 children who underwent ULR (n = 30) or RR (n = 27) for CI-type IXT of less than 25 PD at distance with a postoperative follow-up of 6 months or more were reviewed. Surgical success was defined as an alignment between 10 PD exodeviation and 5 PD esodeviation at distance and near fixation. Read More

View Article and Full-Text PDF

The relationship of antipsychotic treatment with reduced brown adipose tissue activity in patients with schizophrenia.

Psychoneuroendocrinology 2022 Apr 25;142:105775. Epub 2022 Apr 25.

Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan; Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taiwan; Psychiatric Research Center, Taipei Medical University Hospital, 250 Wu-Hsing Street, 110 Taipei, Taiwan. Electronic address:

Background: Antipsychotic drug (APD) treatment has been associated with metabolic abnormalities. Brown adipose tissue (BAT) is the main site of adaptive thermogenesis and secretes various metabolism-improving factors known as batokines. We explored the association of BAT activity with APD treatment and metabolic abnormalities in patients with schizophrenia by measuring the blood levels of bone morphogenetic protein 8b (BMP8b), a batokine secreted by mature BAT. Read More

View Article and Full-Text PDF

Brown Syndrome Secondary to SARS-CoV-2.

J Neuroophthalmol 2022 May 20. Epub 2022 May 20.

Department of Neuroopthalmology, Hospital Doctor Elías Santana, Calle Duarte, Santo Domingo, Dominican Republic.

View Article and Full-Text PDF

A Case of Opsoclonus-Myoclonus-Ataxia With Neuronal Intermediate Filament IgG Detected in Cerebrospinal Fluid.

J Neuroophthalmol 2022 Jun;42(2):278-281

Department of Neurology (MM, JCR, SJF, LJB, SLG), New York University Grossman School of Medicine, New York, New York; Department of Neurology (AM, MDM), Mayo Clinic, Rochester, MN; and Departments of Radiology (JH), Ophthalmology (JCR, LJB, SLG), and Department of Population Health (LJB), New York University Grossman School of Medicine, New York, New York.

Abstract: A 62-year-old man presented with headache, fever, and malaise. He was diagnosed with Anaplasma phagocytophilum, confirmed by serum polymerase chain reaction, and started on oral doxycycline. After 5 days of treatment, the patient began to experience gait imbalance with frequent falls, as well as myoclonus, and confusion. Read More

View Article and Full-Text PDF

Insights into new therapeutic approaches for the treatment and management of polycystic ovary syndrome: An updated review.

Curr Pharm Des 2022 May 18. Epub 2022 May 18.

Departments of Endocrinology and Clinical Research, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir India.

Background: Polycystic ovary syndrome (PCOS) is a long-term, highly prevalent, complex heterogeneous, polygenic endocrine disorder characterized by both metabolic and reproductive disorders. It affects 6-23% of reproductive age women globally.

Objective: This review aims to facilitate an understanding of novel PCOS management approaches and highlights the results from relevant interventional studies from animal and human studies. Read More

View Article and Full-Text PDF

Association between hypertension and osteoarthritis: A systematic review and meta-analysis of observational studies.

J Orthop Translat 2022 Jan 12;32:12-20. Epub 2021 Jun 12.

Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong.

Objective: Literature examining the relationship between elevated blood pressure and osteoarthritis (OA) has yielded conflicting results. This study aimed to systematically review the relationship between hypertension and OA in both load-bearing and non-load-bearing joints.

Methods: A systematic literature search was performed on Embase, Emcare, MEDLINE and Ovid Nursing Database. Read More

View Article and Full-Text PDF
January 2022

Localization of macroscopically undetectable intramedullary hematoma by intraoperative epidural motor evoked potential.

Clin Neurophysiol Pract 2022 22;7:129-134. Epub 2022 Apr 22.

Department of Neurosurgery, University of Szeged, Hungary.

Introduction: Intramedullary hematoma is an uncommon, serious neurological disease, representing a diagnostic challenge. The preferred treatment is surgical. In most of the cases the lesion can be identified macroscopically. Read More

View Article and Full-Text PDF

Delayed recognition of Type II decompression sickness in a diver with chronic atrial fibrillation.

Undersea Hyperb Med 2022 Second Quarter;49(2):563-568

Duke University, Department of Anesthesiology, Division of Hyperbaric Medicine and Environmental Physiology, Durham, North Carolina U.S.

Introduction: This case report describes an initially overlooked Type II decompression sickness (DCS) occurrence that was confused with a cerebral vascular accident in a patient with chronic atrial fibrillation (AF). The purpose of this case report is to reinforce the maxim that DCS needs to be suspected anytime a scuba diver experiences signs or symptoms compatible with DCS after completing a scuba dive.

Methods: A 71-year-old scuba diver with a history of AF and who was taking warfarin made four dives, all with maximum depths less than 60 fsw (20 msw) over a 10-hour interval. Read More

View Article and Full-Text PDF

Real-World Use of Tisagenlecleucel in Infant Acute Lymphoblastic Leukemia.

Blood Adv 2022 May 17. Epub 2022 May 17.

Stanford University, Palo Alto, California, United States.

Infants with B-cell acute lymphoblastic leukemia (B-ALL) have poor outcomes due to chemotherapy resistance leading to high relapse rates. Tisagenlecleucel, a CD19-directed chimeric antigen receptor T-cell (CART) therapy, is FDA approved for relapsed or refractory (R/R) B-ALL in patients ≤25 years; however, the safety and efficacy of this therapy in young patients is largely unknown since children <3 years of age were excluded from licensing studies. We retrospectively evaluated data from the Pediatric Real-World CAR Consortium to examine outcomes of patients with infant B-ALL who received tisagenlecleucel between 2017 and 2020 (n=14). Read More

View Article and Full-Text PDF

Impact of adverse childhood experiences on the symptom severity of different mental disorders: a cross-diagnostic study.

Gen Psychiatr 2022 22;35(2):e100741. Epub 2022 Apr 22.

Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Adverse childhood experiences have a significant impact on different mental disorders.

Objective: To compare differences in adverse childhood experiences among those with different mental disorders and their relationships in a cross-disorder manner.

Methods: The study included 1513 individuals aged ≥18 years : 339 patients with substance use disorders, 125 patients with schizophrenia, 342 patients with depression, 136 patients with bipolar disorder, 431 patients with obsessive-compulsive disorder (OCD), and 140 healthy controls. Read More

View Article and Full-Text PDF

Irisin reduces inflammatory signaling pathways in inflammation-mediated metabolic syndrome.

Mol Cell Endocrinol 2022 May 13;552:111676. Epub 2022 May 13.

Department of Plastic Surgery, Department of Surgery, Rhode Island Hospital, Warren Alpert School of Medicine, 593 Eddy St. Providence, RI, 02903, USA. Electronic address:

Irisin is an exercise induced myokine first shown to induce the browning of white adipose tissue (WAT) which increases energy expenditure, improves glucose tolerance, and reduces insulin resistance. Among irisin's involvement in lipid homeostasis, osteoblast proliferation, and muscle growth, it also acts as a mediator of many inflammatory pathways throughout the body. This review aims to describe the role of irisin in inflammatory processes and understand how targeting irisin can alter the inflammatory response in metabolic syndrome (MetS). Read More

View Article and Full-Text PDF

Transhemispheric remodeling the motor cortex promotes forelimb recovery after mouse spinal cord injury.

JCI Insight 2022 May 12. Epub 2022 May 12.

Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, United States of America.

Understanding the reorganization of neural circuits spared after spinal cord injury in the motor cortex and spinal cord would provide insight for developing therapeutics. Using optogenetic mapping we demonstrate a transhemispheric recruitment of neural circuits in the contralateral cortical M1/M2 area to improve the impaired forelimb function after a cervical 5 right-sided hemisection in mice, a model mimicking the human Brown-Séquard syndrome. This cortical reorganization can be elicited by a selective cortical optogenetic neuromodulation paradigm. Read More

View Article and Full-Text PDF

Delta spike P681R mutation enhances SARS-CoV-2 fitness over Alpha variant.

Cell Rep 2022 May 29;39(7):110829. Epub 2022 Apr 29.

Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX, USA; Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX, USA; World Reference Center for Emerging Viruses and Arboviruses, University of Texas Medical Branch, Galveston, TX, USA. Electronic address:

We report that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta spike mutation P681R plays a key role in the Alpha-to-Delta variant replacement during the coronavirus disease 2019 (COVID-19) pandemic. Delta SARS-CoV-2 efficiently outcompetes the Alpha variant in human lung epithelial cells and primary human airway tissues. The Delta spike mutation P681R is located at a furin cleavage site that separates the spike 1 (S1) and S2 subunits. Read More

View Article and Full-Text PDF

Anatomical Safe Zones for Arthroscopic Snapping Scapula Surgery: Quantitative Anatomy of the Superomedial Scapula and Associated Neurovascular Structures and the Effects of Arm Positioning on Safety.

J Shoulder Elbow Surg 2022 May 9. Epub 2022 May 9.

Steadman Philippon Research Institute, Vail, CO, USA; The Steadman Clinic, Vail, CO, USA. Electronic address:

Background: Neurovascular anatomy has not been previously quantified for the arthroscopic snapping scapula approach with the patient in the most frequent patient position (chicken wing). The purposes of this study are to 1) determine anatomical relationships of the superomedial scapula and neurovascular structures at risk during arthroscopic surgical treatment of snapping scapula syndrome (SSS), 2) compare these measurements between the arm in neutral and "chicken wing" positions, and 3) to establish safe zones for arthroscopic treatment of SSS.

Methods: Eight fresh-frozen cadaveric hemi-torsos (mean age, 55. Read More

View Article and Full-Text PDF

Comparison of image-based quantification methods in evaluating fixation stability using a remote eye tracker in abnormal phoria.

J Int Med Res 2022 May;50(5):3000605221098183

Department of Optometry, Kangwon National University, Samcheok, South Korea.

Objective: This study was performed to establish a quantitative evaluation and comparison of fixation stability, as measured by an eye tracker, using image-based areas determined by the bivariate contour ellipse area (BCEA), kernel density estimation (KDE), and Scanpath methods.

Methods: This prospective cross-sectional study included 45 and 20 participants with abnormal and normal phoria, respectively. Eye movements were recorded using a remote eye tracker and were plotted using RStudio software. Read More

View Article and Full-Text PDF

mutations in intellectual disability and epilepsy: A report of 2 cases and literature review.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Feb;47(2):265-270

Department of Pediatrics, Xiangya Hospital, Central South University; Research Center of Children Intellectual Disability of Hunan Province, Changsha 410008, China.

More than 100 genes located on the X chromosome have been found to be associated with X-linked intellectual disability (XLID) to date, and is a pathogenic gene for XLID. In addition to intellectual disability, patients with gene mutation can also have other neurological symptoms, such as epilepsy, abnormal behavior, and hypotonia, as well as abnormalities of other systems. Two children with intellectual disability and epilepsy caused by gene mutation were treated in the Department of Pediatrics, Xiangya Hospital, Central South University from March 8, 2017 to June 20, 2020. Read More

View Article and Full-Text PDF
February 2022

Evaluation of mRNA-1273 Covid-19 Vaccine in Children 6 to 11 Years of Age.

N Engl J Med 2022 May 11;386(21):2011-2023. Epub 2022 May 11.

From the Vanderbilt Vaccine Research Program, Department of Pediatrics, Vanderbilt University Medical Center (C.B.C.), and Meharry Medical College (V.B.) - both in Nashville; the Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta and the Department of Pediatrics, Emory University School of Medicine - both in Atlanta (E.A.); the Department of Pediatrics, Yale School of Medicine, the Department of Epidemiology of Microbial Diseases, Yale School of Public Health, and the Yale Institute for Global Health - all in New Haven, CT (I.Y.); the Medical University of South Carolina (A.M.A.) and Coastal Pediatric Associates (R.A.C.) - both in Charleston; Boca Raton Clinical Research Global, Edinburg (I.M.B.), Tekton Research, Austin (P.P.), Highland Woods Health, The Woodlands (C.Y.), Texas Health Care, Privia Medical Group-North Texas, Fort Worth, and Forest Lane Pediatrics, Dallas (R.B.) - all in Texas; Capitol Medical Group, Chevy Chase (D.F.), and the Department of Pediatrics, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore (J.D.C.) - both in Maryland; Privia Medical Group, Arlington, VA (D.F., C.Y.); Velocity Clinical Research, Banning, CA (J.K.); Javara, Winston-Salem (C.Y., R.B.), and the Department of Surgery, Duke University Medical Center, Durham (D.C.M.) - both in North Carolina; Quality Clinical Research, Omaha, NE (M.D.); and Moderna, Cambridge, MA (J.E.T., X.Z., W.D., H.Z., D.R.S., K.H., B.G., K.S., R.M., R.P., R.D., J.M.M., S.S.G.).

Background: Vaccination of children to prevent coronavirus disease 2019 (Covid-19) is an urgent public health need. The safety, immunogenicity, and efficacy of the mRNA-1273 vaccine in children 6 to 11 years of age are unknown.

Methods: Part 1 of this ongoing phase 2-3 trial was open label for dose selection; part 2 was an observer-blinded, placebo-controlled expansion evaluation of the selected dose. Read More

View Article and Full-Text PDF