39,048 results match your criteria Bronchitis
Environ Epidemiol 2018 Jun;2(2)
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Background: Bronchitic symptoms in children pose a significant clinical and public health burden. Exposures to criteria air pollutants affect bronchitic symptoms, especially in children with asthma. Less is known about near-roadway exposures. Read More
Biomed Res Int 2018 4;2018:1252897. Epub 2018 Nov 4.
School of Dentistry, College of Oral Medicine, Taipei Medical University, 250 Wu-Hsing Street, Taipei, Taiwan.
The effect of comorbidity on lung cancer patients' survival has been widely reported. The aim of this study was to investigate the effects of comorbidity on the establishment of the diagnosis of lung cancer and survival in lung cancer patients in Taiwan by using a nationwide population-based study design. This study collected various comorbidity patients and analyzed data regarding the lung cancer diagnosis and survival during a 16-year follow-up period (1995-2010). Read More
Infect Drug Resist 2018 8;11:2199-2205. Epub 2018 Nov 8.
Department of Health Sciences, Medical School, University of Catanzaro "Magna Græcia", Catanzaro, Italy,
Purpose: The overuse, misuse, and underuse of antimicrobial agents often lead to the spread of antibiotic-resistant microorganisms. The aim of our study was to describe the pattern of antibiotic prescriptions for acute respiratory tract infections (RTIs) among the adult population and the factors associated with antibiotic prescribing.
Patients And Methods: The study involved patients who visited a general practitioner with suspected acute RTI. Read More
Expert Rev Respir Med 2018 Dec 6. Epub 2018 Dec 6.
b Division of Pulmonology, Department of Internal Medicine, Charlotte Maxeke Johannesburg Academic Hospital and Faculty of Health Sciences , University of the Witwatersrand , Johannesburg , South Africa .
Introduction: Lower respiratory tract infections (LRTIs) are the leading infectious disease cause of death in the world and the fifth overall cause of death. From an epidemiological point of view, most consider pneumonia, influenza, bronchitis (including acute exacerbations in chronic obstructive pulmonary disease [AECOPD]), and bronchiolitis to be the most important LRTIs. Areas covered: This review will describe the epidemiology of LRTIs in adults focusing on community-acquired pneumonia, influenza, and AECOPD, utilizing data from the more recent literature. Read More
Avian Pathol 2018 Dec 6:1-27. Epub 2018 Dec 6.
c 138 Hartford Road, Huntingdon, Cambridgeshire , PE29 1XQ , UK .
In an initial study in SPF chickens, a heterologous virus neutralising (VN) antibody response to IBV variants Q1, Variant 2 (Var 2), D388/QX (D388), D274 and Arkansas (DPI) was observed using a vaccination programme incorporating two different live-attenuated IBV vaccines, followed by boosting with an inactivated vaccine containing IBV Massachusetts (Mass) antigen. Therefore, a more detailed study was undertaken in SPF layer-type chickens previously primed with IBV Mass and 793B live-attenuated vaccines. The efficacy of single or repeated vaccination with a multivalent inactivated vaccine containing IBV antigen was determined against challenge with 5 virulent IBVs: Mass (M41), 793B (4/91), D388, Q1 and Var 2. Read More
Open Respir Med J 2018 26;12:50-66. Epub 2018 Oct 26.
Clinic for Paediatrics, Evangelic Hospital Hamm, Hamm, Germany.
Background: There are no validated standardised clinical procedures for severity measurement of acute bronchitis in children. The "BSS-ped", a short version of the physician-rated assessment scale BSS (Bronchitis Severity Scale), can fill this gap, if it is valid.
Objective: To examine the scale´s validity. Read More
Saudi J Biol Sci 2018 Nov 3;25(7):1302-1307. Epub 2018 Apr 3.
Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
This study was conducted on 100 one-day-old broiler chicks to evaluate the effect of Poulvac vaccine in reduction of clinical signs and complications after concurrent infectious bronchitis virus (variant 02) and virulent O78 challenges. The birds were evaluated for clinical signs, mortality for 7 days post-infection, PM lesion score, average body weight and serological evaluation. Re-isolation and RT-PCR for the challenging infectious bronchitis virus (IBV) variant 02 were conducted thereafter. Read More
Am J Case Rep 2018 Dec 3;19:1434-1436. Epub 2018 Dec 3.
Department of Internal Medicine, Wayne State University, Rochester Hills, MI, USA.
BACKGROUND Lymphatic circulation in the thorax enters the systemic blood flow at the subclavian vein. Instances where diversion occurs leads to complications such as pleural effusion. A rare complication of lymphatic diversion results in fluid accumulation in the bronchial tree, causing plastic bronchitis. Read More
Crit Care Nurse 2018 Dec;38(6):e5-e12
Christine Peyton is a clinical nurse specialist at the Heart Institute at Children's Hospital Colorado, Aurora, Colorado.
Protein-losing enteropathy and plastic bronchitis remain challenging to treat despite recent treatment advances. Protein-losing enteropathy and plastic bronchitis have been diagnosed in patients with cardiomyopathy, constrictive pericarditis, and congestive heart failure. This article focuses on patients with protein-losing enteropathy or plastic bronchitis following the Fontan procedure. Read More
Zhonghua Er Ke Za Zhi 2018 Dec;56(12):929-932
Department of Pediatric Emergency Medicine, Children's Hospital of Fudan University, Shanghai 201102, China.
To survey the conduction and evaluate the effectiveness of extracorporeal membrane oxygenation (ECMO) therapy in pediatric intensive care unit (PICU) in China mainland. In a questionnaire-based survey, we retrospectively reviewed the application of ECMO in children's hospital and general hospital in China mainland to summarize and analyze the categories of diseases and prognosis of children treated with ECMO therapy. By December 31, 2017, a total of 23 hospitals using ECMO, including 22 tertiary referral hospitals and 1 secondary hospital, among which 16 were children's hospitals and 7 were general hospitals. Read More
Clin Transl Med 2018 Dec 5;7(1):39. Epub 2018 Dec 5.
School of Medicine, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, Australia.
Chronic exposure to household indoor smoke and outdoor air pollution is a major contributor to global morbidity and mortality. The majority of these deaths occur in low and middle-income countries. Children, women, the elderly and people with underlying chronic conditions are most affected. Read More
Int J Biometeorol 2018 Nov 29. Epub 2018 Nov 29.
Postgraduate Program of Meteorology, College of Meteorology, Federal University of Pelotas, Av. Idelfonso Simões Lopes, 2751, Arco-Íris, Pelotas, 96060290, Brazil.
The southern Brazilian city of Canoas, situated in the metropolitan region of Porto Alegre, is subject to several annual meteorological phenomena, such as cold fronts and squall lines. Here, we assess the relationship between meteorological conditions and outpatient consultations for asthma or bronchitis in children from Canoas City. Data from outpatient consultations of children (below 9 years), between January/2005 and September/2008, were combined with daily meteorological data from 12UTC (morning) and 18UTC (afternoon). Read More
Immunopharmacol Immunotoxicol 2018 Nov 29:1-9. Epub 2018 Nov 29.
c Chemical Injuries Research Center, Systems Biology and Poisonings Institute , Baqiyatallah University of Medical Sciences , Tehran , Iran.
Sulfur mustard (SM) is a toxic agent which causes severe abnormalities in an airway system such as necrosis and inflammation, oxidative stress, chronic bronchitis, shortness of breath, and chronic obstructive pulmonary disease. Although possible mechanisms of SM toxicity have been extensively considered, there is still need to find an appropriate clinical treatment to decrease chronic lung injuries caused by SM. Due to extensive progresses and achievement in tissue repairing through stem cells therapy, the importance of cell therapy for the treatment of lung injuries has been increased. Read More
Avian Pathol 2018 Nov 28:1-35. Epub 2018 Nov 28.
a GD - Animal Health , Arnsbergstraat 7, 7418 EZ , Deventer , the Netherlands.
An outbreak of low pathogenic avian influenza (LPAI) subtype H6N1 (intravenous pathogenicity index = 0.11) infection occurred in four productive brown layer flocks on three farms in the Netherlands within a period of two months. The farms were located at a maximum distance of 4. Read More
Occup Environ Med 2018 Nov 27. Epub 2018 Nov 27.
Service Hospitalier Universitaire Pneumologie Physiologie, Pôle Thorax et Vaisseaux, Grenoble, France.
Introduction: The current definition of chronic obstructive pulmonary disease (COPD) associates persistent airflow limitation and chronic respiratory symptoms. Agricultural work has been associated with an increased risk of developing COPD, but the prevalence and definition of the disease vary greatly between studies. This meta-analysis aimed to assess the association between agricultural work and COPD using the most widely used definitions of the disease. Read More
Poult Sci 2018 Nov 23. Epub 2018 Nov 23.
Southern Poultry Research Group, Inc., Watkinsville, GA 30677, USA.
This 42-day study evaluated the effects of dietary supplementation with β-1,3-glucan (Aleta™) on the vaccination response to Newcastle disease virus (NDV), avian infectious bronchitis virus (IBV), and infectious bursal disease (IBD) in a non-challenged environment. This trial included 600 chicks (all vaccinated with IBD at the hatchery) which were assigned to 1 of 3 treatments: vaccination (NDV, IBV), no vaccination, or vaccination combined with feed supplemented with Aleta (100 g/MT of feed). The vaccination with Aleta treatment group showed a trend for improved FCR that was not statistically significant. Read More
Poult Sci 2018 Nov 24. Epub 2018 Nov 24.
Guangdong Laboratory Animals Monitoring Institute, Guangzhou 510640, China.
Using Luminex xMAP (x = analyte, MAP = multi-analyte profiling) technology, a serological method for the simultaneous detection of antibodies to Newcastle disease virus (NDV) and avian influenza virus (AIV) was established. Nano-magnetic beads coated with purified NDV protein and AIV nucleoprotein were incubated with serum samples. Using biotinylated rabbit anti-chicken IgY and streptavidin-R-phycoerythrin, the optical signals measured by a Luminex 200 detection system indicated the quantification of NDV or AIV antibodies in the serum. Read More
Antiinflamm Antiallergy Agents Med Chem 2018 Nov 26. Epub 2018 Nov 26.
Medical Laboratory Department, University College - Turabah, Taif University. Saudi Arabia.
Background: Chronic inflammation is a critical health issue and implicated in several chronic health problems such as tumors, auto-immune disorder, hypertension or diabetes. However, Juniperus procera is one of the famous ancient plants that been traditionally used to treat several diseases such as hyperglycemia, hepatitis, jaundice, bronchitis, and pneumonia.
Objective: Current study is an attempt to investigate the anti-inflammatory effect of juniperus procera extract on rats exposed to cytotoxicity caused experimentally by streptozotocin injections. Read More
Vet Microbiol 2018 Dec 24;227:20-28. Epub 2018 Oct 24.
Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China. Electronic address:
TW-like IBV isolates have appeared frequently in recent years in mainland China. In this study, we compared the TW-like IBV GD strain and the predominant QX-like SD strain in terms of serology and pathogenicity to 3-week-old specific-pathogen-free chickens. Both strains could cause severe respiratory distress and renal lesions, with a mortality rate were approximately 20%. Read More
Acta Virol 2018 ;62(4):374-378
Infectious bronchitis virus (IBV), a major pathogen of the domestic fowl, exhibits extensive antigenic variation. IBV is a member of the Coronaviridae family and the genus Gammacoronavirus. A new infectious bronchitis virus serotype can emerge from only very few amino acid changes within the major peplomer glycoprotein, namely in its S1 part forming the virion spike. Read More
Am J Emerg Med 2018 Nov 17. Epub 2018 Nov 17.
Northwell North Shore University Hospital, Department of Emergency Medicine, 300 Community Dr, Manhasset, NY 11030, United States of America. Electronic address:
Objective: We studied the impact four new urgent care centers (UCCs) had on a hospital emergency department (ED) in terms of overall census and proportion of low acuity diagnoses from 2009 to 2016. We hypothesized that low acuity medical problems frequently seen in UCCs would decrease in the ED population. Since Medicaid was not accepted at these UCCs, we also studied the Medicaid vs non-Medicaid discharged populations to see if there were some differences related to access to urgent care. Read More
Med Sci Monit 2018 Nov 24;24:8481-8488. Epub 2018 Nov 24.
Department of Anesthesiology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu, China (mainland).
BACKGROUND This study was conducted to evaluate the effects of astragaloside IV and budesonide on bronchitis in rats and to explore the mechanism involved. MATERIAL AND METHODS Eighty Sprague-Dawley (SD) rats were randomly divided into 5 groups, including a Bronchitis model group (BM), a Budesonide group (BG), an Astragaloside IV group (AG), an Astragaloside IV combined with Budesonide group (CG), and a blank control group (BC). Lung tissue was stained with hematoxylin and eosin (H&E). Read More
BMC Med Res Methodol 2018 Nov 22;18(1):149. Epub 2018 Nov 22.
Instituto Nacional de Salud Pública, Centro de Investigación en Salud Poblacional, Cuernavaca, Morelos, Mexico.
Background: Bronchiolitis is a common respiratory disorder in children. Although there are specific ICD-9-CM diagnosis codes for bronchiolitis, the illness is often coded using broader diagnosis codes. This creates the potential for subject misclassification if researchers rely on specific diagnosis codes when assembling retrospective cohorts. Read More
Viruses 2018 Nov 19;10(11). Epub 2018 Nov 19.
Reseach Institute for Veterinary Science, College of Veterinary Medicine, BK21 for Veterinary Science, Seoul 08826, Korea.
We established a cold-adapted infectious bronchitis virus (BP-caKII) by passaging a field virus through specific pathogen-free embryonated eggs 20 times at 32 °C. We characterized its growth kinetics and pathogenicity in embryonated eggs, and its tropism and persistence in different tissues from chickens; then, we evaluated pathogenicity by using a new premature reproductive tract pathogenicity model. Furthermore, we determined the complete genomic sequence of BP-caKII to understand the genetic changes related to cold adaptation. Read More
Expert Opin Pharmacother 2018 Nov 21:1-3. Epub 2018 Nov 21.
f Department of Surgery-Thoracic Surgery , Grigore T Popa University of Medicine and Pharmacy , Iasi , Romania.
Introduction: For patients with chronic obstructive pulmonary disease (COPD), one of the main goals in its management is to reduce the number of disease exacerbations. Roflumilast is an anti-inflammatory compound used in patients with advanced COPD and chronic bronchitis in order to fulfill this objective. However, this is not always easily achieved due to the heterogeneity of the population. Read More
Clin Infect Dis 2018 Nov 19. Epub 2018 Nov 19.
Novavax, Gaithersburg, MD. USA.
Background: Respiratory syncytial virus (RSV) is an important but under-recognized cause of serious respiratory illness in adults. Recent comparative data on RSV and influenza infection in hospitalized adults may increase awareness of RSV disease burden in adults.
Methods: Hospitalized adults ≥60 years old testing positive for RSV or influenza by multiplex RT-PCR or viral culture between 01/01/2011 and 06/30/2015 were identified from Kaiser Permanente Southern California electronic medical records. Read More
Respir Med Case Rep 2019 3;26:9-10. Epub 2018 Nov 3.
SRxA Strategic Pharmaceutical Advisors, 1750 Tysons Boulevard, Suite 1500, McLean, VA 22102, USA.
We read with interest the recent case reports in this journal on the apparent beneficial effects of long-term, high-dose guaifenesin in patients with chronic respiratory disease. This prompted us to review our own patient database as we also recommend daily guaifenesin to patients who report problems with mucociliary clearance. In our rural primary care practice, we currently have over 20 patients who have taken guaifenesin daily, for more than 3 years as an adjuvant to their prescribed medications for either chronic obstructive pulmonary disease (COPD) and/or stable chronic bronchitis. Read More
Viruses 2018 Nov 15;10(11). Epub 2018 Nov 15.
Faculty of Veterinary Medicine, University of Calgary, Health Research Innovation Center, 3330 Hospital Drive NW, Calgary, AB T2N 4N1, Canada.
The in ovo delivery of cytosine-guanosine (CpG) oligodeoxynucleotides (ODNs) protects chickens against many bacterial and viral infections, by activating the toll-like receptor (TLR)21 signaling pathway. Although the delivery of CpG ODNs in ovo at embryo day (ED) 18 has been shown to reduce infectious bronchitis virus (IBV) loads in embryonic chicken lungs pre-hatch, whether in ovo delivered CpG ODNs are capable of protecting chickens against a post-hatch challenge is unknown. Thus, our objectives were to determine the protective effect of the in ovo delivery of CpG ODNs at ED 18 against IBV infection encountered post-hatch and, then, to investigate the mechanisms of protection. Read More
ERJ Open Res 2018 Oct 12;4(4). Epub 2018 Nov 12.
Dept of Medicine, National Jewish Health, Denver, CO, USA.
Low socioeconomic status has been associated with chronic obstructive pulmonary disease (COPD) but little is known about its impact on disease progression. We assessed the association of income to symptoms, pulmonary disease severity and progression in smokers with and without COPD. The COPDGene cohort of 4826 smokers who reported annual income in phase 2 was analysed. Read More
BMC Vet Res 2018 Nov 15;14(1):347. Epub 2018 Nov 15.
Guangdong Laboratory Animals Monitoring Institute and Guangdong Provincial Key Laboratory of Laboratory Animals, Guangzhou, 510633, China.
Background: Chicken anemia virus (CAV), avian reovirus (ARV), infectious bursal disease virus (IBDV), Marek's disease virus (MDV) and reticuloendotheliosis virus (REV) all cause immunosuppressive disease in birds through vertical or horizontal transmission. Mixed infections with these immunosuppressive pathogens lead to atypical clinical signs and obstruct accurate diagnoses and epidemiological investigations. Therefore, it is essential to develop a high-throughput assay for the simultaneous detection of these immunosuppressive viruses with high specificity and sensitivity. Read More
Biochimie 2018 Nov 13;157:111-122. Epub 2018 Nov 13.
Department of Chemistry, Faculty of Experimental Sciences, University of Huelva, Campus El Carmen, Research Center on Health and Environment (RENSMA), 21007, Huelva, Spain. Electronic address:
The high prevalence of lung cancer (LC) has triggered the search of biomarkers for early diagnosis of this disease. For this purpose the study of metabolic changes related to the development of lung cancer could provide interesting information about its early diagnosis. In this sense, chronic obstructive pulmonary disease (COPD), a disease associated with tumor development, is a comorbidity that increases the risk of onset and progression of lung neoplasia and has also to be considered in the study of pathology related to lung cancer. Read More
Ann Am Thorac Soc 2018 Nov;15(Supplement_3):S216-S226
4 Marsico Lung Institute, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina.
A spectrum of intrapulmonary airway diseases, for example, cigarette smoke-induced bronchitis, cystic fibrosis, primary ciliary dyskinesia, and non-cystic fibrosis bronchiectasis, can be categorized as "mucoobstructive" airway diseases. A common theme for these diseases appears to be the failure to properly regulate mucus concentration, producing mucus hyperconcentration that slows mucus transport and, importantly, generates plaque/plug adhesion to airway surfaces. These mucus plaques/plugs generate long diffusion distances for oxygen, producing hypoxic niches within adherent airway mucus and subjacent epithelia. Read More
South Asian J Cancer 2018 Oct-Dec;7(4):267-269
Department of Radiation Oncology, Cancer Research Institute, SRHU, Dehradun, Uttarakhand, India.
Purpose: The aim of the study was to evaluate the short-term clinical, endoscopic response, and acute toxicities in endobronchial cancer treated with high-dose-rate endobronchial brachytherapy (HDR-EB).
Materials And Methods: Thirty patients of advanced endobronchial cancers were treated with HDR-EB. Brachytherapy was delivered at a depth of 1 cm from the source axis at weeks 1, 2, and 3 with 7 Gy per fraction. Read More
Rev Mal Respir 2018 Nov 11. Epub 2018 Nov 11.
Université Cheikh Anta Diop, faculté de médecine service de pneumologie de Fann, Dakar, Sénégal. Electronic address:
Introduction: Bronchial mould infection or plastic bronchitis is a rare condition, encountered at any age, but with a predilection for childhood. The clinical diagnosis is made easy by the demonstration of solid, branched expectorations. However, the aetiology is not easy to determine and investigation does not often lead to a pathological diagnosis. Read More
JMM Case Rep 2018 Sep 10;5(9):e005133. Epub 2018 Jan 10.
Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Introduction: are Gram-positive partially acid-fast bacilli capable of inducing a wide range of infections in patients with immunodeficiency, AIDS, cancer, lupus erythematous and diabetes. was first isolated in 2001 from a patient with chronic bronchitis. Since then, there have been reports on the clinical significance of this organism in patients with bronchitis, brain abscess and lung diseases. Read More
J Clin Med 2018 Nov 9;7(11). Epub 2018 Nov 9.
Department of Pediatrics, Hsinchu MacKay Memorial Hospital, Hsinchu 30071, Taiwan.
Children are susceptible to a variety of respiratory infections. Wheezing is a common sign presented by children with respiratory infections. Asthma, bronchiolitis, and bronchitis are common causes of childhood wheezing disease (CWD) and are regarded as overlapping disease spectra. Read More
Med Sci Monit 2018 Nov 13;24:8160-8171. Epub 2018 Nov 13.
Spinal Surgery Department, Tianjin Hospital, Tianjin, China (mainland).
BACKGROUND Baclofen is approved by the US FDA to treat spasticity, but its sustained use may cause drug addiction. The objective of this study was to compare the efficacy and safety of botulinum toxin type A versus baclofen in spasticity. MATERIAL AND METHODS A total of 336 patients who had spasticity caused by spinal cord injury were enrolled in a randomized (in 1: 1: 1: ratio) for placebo, controlled trial. Read More
Lymphology 2018 ;51(3):97-101
Department of Radiology, Division of Vascular and Interventional Radiology, University of Michigan Health System, Ann Arbor, Michigan, USA.
Plastic bronchitis is a poorly understood and uncommon diagnosis, arising from multiple etiologies. Traditional treatment consists of steroids and vasodilators, with thoracic duct embolization emerging as a new procedural therapy. Herein, abnormal lymphatic vessels were noted on lymphangiography in an adult patient with debilitating plastic bronchitis, but anterograde lymphatic access was not feasible due to the patient's morbid obesity and non-visualization of retroperitoneal lymphatics. Read More
J Chromatogr B Analyt Technol Biomed Life Sci 2018 Nov 6;1104:11-17. Epub 2018 Nov 6.
Liaoning University of Traditional Chinese Medicine, Dalian 116600, PR China. Electronic address:
Leontopodium leontopodioides (Willd.) Beauv. is used therapeutically to prevent numerous diseases. Read More
Rev Mal Respir 2018 Nov 8. Epub 2018 Nov 8.
Département d'enseignement et de recherche en médecine générale, faculté de médecine, université Nice-Sophia-Antipolis, 06107 Nice, France.
Introduction: This qualitative study aimed to explore the real life experience of the patients with chronic obstructive pulmonary disease (COPD) at the time they receive the diagnosis.
Methods: Data were collected using face to face interviews in general practice as well as focus groups in a pulmonary rehabilitation centre.
Results: Thirty-four patients participated in the study. Read More
Clin Exp Allergy 2018 Nov 11. Epub 2018 Nov 11.
State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
Background: The pathogenesis and pathophysiology of eosinophilia-related chronic cough such as non-asthmatic eosinophilic bronchitis and cough variant asthma are still not clear.
Objective: This study is to examine the potential role of traffic-related air pollution (TRAP) in eosinophilic inflammation and cough responses.
Methods: Non-sensitized guinea pigs were exposed to TRAP in an urban traffic tunnel or kept in a filtered air environment for 7 or 14 days. Read More
Multidiscip Respir Med 2018 2;13:40. Epub 2018 Nov 2.
2Preventive Medicine Department, Hospital Universitario Infanta Cristina, Parla, Madrid, Spain.
Fifteen years after its licensure, this revision assesses the role of cefditoren facing the current pharmacoepidemiology of resistances in respiratory human-adapted pathogens (, , and ). In the era of post- pneumococcal conjugate vaccines and in an environment of increasing diffusion of the I gene among isolates, published studies on the cefditoren in vitro microbiological activity, pharmacokinetic/pharmcodynamic (PK/PD) activity and clinical efficacy are reviewed. Based on published data, an overall analysis is performed for PK/PD susceptibility interpretation. Read More
Pediatr Infect Dis J 2018 Dec;37(12):1248-1254
Medical and Clinical Pharmacy Policy, Anthem, Inc, Chicago, Illinois.
Background: Antibiotics are commonly prescribed for children with acute respiratory infections (ARIs). This study describes the distribution of ARI diagnoses and specifically quantifies antibiotic dispensing for bronchitis and upper respiratory infection (URI) by treatment setting and specialty.
Methods: This retrospective, observational cross-sectional study used data from the HealthCore Integrated Research Environment containing claims from 14 commercial health plans for 2012 to 2014. Read More
Osong Public Health Res Perspect 2018 Oct;9(5):248-254
Department of Biostatistics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Objectives: To investigate the chronological patterns of diseases in Northern Gyeonggi-do province, South Korea, and compare these with national data.
Methods: A National Health Insurance cohort based on the National Health Information Database (NHID Cohort 2002-2013) was used to perform a retrospective, population-based study (46,605,433 of the target population, of which 1,025,340 were randomly sampled) to identify disease patterns from 2002 to 2013. Common diseases including malaria, cancer (uterine cervix, urinary bladder, colon), diabetes mellitus, psychiatric disorders, hypertension, intracranial hemorrhage, bronchitis/bronchiolitis, peptic ulcer, and end stage renal disease were evaluated. Read More
Environ Res 2018 Oct 27;169:1-6. Epub 2018 Oct 27.
Univ Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000 Rennes, France; Department of Epidemiology and Public Health, University Hospital, F-35033 Rennes, France. Electronic address:
Background: The AIRBAg study was designed to assess the prevalence of chronic obstructive pulmonary disease (COPD) in dairy farmers and to define its associated risk factors.
Methods: Between March 2012 and February 2017 randomly selected dairy farmers in the French region of Brittany were asked to complete a self-administered questionnaire and undergo an occupational health check-up with electronic mini-spirometry and standard spirometry. Those having one or more of the following features: chronic cough, chronic bronchitis, wheezing, dyspnea and/or a ratio FEV/FEV < 80% were then referred to a pulmonologist for further check-up including spirometry with a reversibility test. Read More
Daru 2018 Dec 3;26(2):199-207. Epub 2018 Nov 3.
Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran.
Background: Fluoroquinolones (FQs) are compounds of major interest with broad antimicrobial activities against community and hospital-acquired infections such as respiratory tract infections (nosocomial pneumonia, chronic bronchitis and tuberculosis), skin and soft tissue infections, bone and joint infections, intra-abdominal infections and sexually transmitted diseases. This broad range of activities along with favorable pharmacokinetic and low toxicity introduced this class of compounds as important antimicrobial chemotherapy agents. The rapid increase in prevalence of FQs resistant microbes in environment motivated medicinal chemists to discover new quinolone-based compounds with potent activities against Gram-positive bacteria. Read More
Transbound Emerg Dis 2018 Nov 3. Epub 2018 Nov 3.
Department of Virology, Animal & Plant Health Agency-Weybridge, Woodham Lane, New Haw, , Addlestone, Surrey, KT15 3NB, United Kingdom.
A detailed veterinary and laboratory investigation revealed an unusual case of concurrent avian avulavirus type 1 (AAvV-1, formerly called avian paramyxovirus type 1)) and low pathogenicity avian influenza (LPAI) virus infections of chickens during March 2010 in a mixed poultry and livestock farm in Great Britain. Respiratory signs and daily mortality of 5-6 birds in a broiler flock 8-weeks of age prompted submission of two carcasses to an Animal and Plant Health Agency (APHA) regional laboratory. Infectious bronchitis virus infection was suspected initially and virus isolation in SPF embryonated fowls' eggs was attempted at APHA-Weybridge. Read More
Dig Dis Sci 2018 Nov 2. Epub 2018 Nov 2.
Takeda Development Center Americas, Inc, Deerfield, IL, USA.
Background: In gastroesophageal reflux disease (GERD), the frequency of heartburn symptoms and erosive esophagitis (EE) increases with age in children and adolescents. Proton pump inhibitor, dexlansoprazole, is approved for healing EE of all grades, maintenance of healed EE, relief of heartburn, and treatment of symptomatic non-erosive GERD in patients ≥ 12 years.
Aim: To assess safety and efficacy of dexlansoprazole dual delayed-release capsule in healing of EE and maintenance of healed EE in adolescents. Read More
Turk J Med Sci 2018 Oct 31;48(5):945-951. Epub 2018 Oct 31.
Background/aim: This study performed typing of chronic obstructive pulmonary disease (COPD) using high-resolution computed tomography (HRCT) to determine the association with smoking, matrix metalloproteinases, and common comorbidities. Materials and methods: The study enrolled 94 hospitalized patients. Participants were divided into a group of 69 current and former smokers (group A) and a group of 25 that had never smoked (group B). Read More