40,672 results match your criteria Bronchitis


Serum vitamin D is associated with improved lung function markers but not with prevalence of asthma, emphysema, and chronic bronchitis.

Sci Rep 2020 Jul 9;10(1):11542. Epub 2020 Jul 9.

Human Nutrition Department, College of Health Sciences, QU Health, Qatar University, P.O.Box 2713, Doha, Qatar.

Hypovitaminosis D has been linked to several non-bone diseases. Relation between 25-hydroxyvitamin D [25(OH)D] and lung function and lung diseases has received little attention at the global level. Cross-sectional data from three National Health and Nutrition Examination Surveys, 2007-2008, 2009-2010, and 2011-2012 were used to investigate the relationship between serum 25(OH)D concentrations and lung function makers [forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1)] and lung diseases (asthma, emphysema, and chronic bronchitis) with multivariate regression models (n = 11,983; men, 6,010; women, 5,973). Read More

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http://dx.doi.org/10.1038/s41598-020-67967-7DOI Listing

A review of Saurauia roxburghii Wall. (Actinidiacaea) as a traditional medicinal plant, its phytochemical study and therapeutic potential.

Mini Rev Med Chem 2020 Jul 9. Epub 2020 Jul 9.

Molecular Modeling Drug-design and Discovery Laboratory, Pharmacology Research Division, BCSIR Laboratories Chattogram, Bangladesh Council of Scientific and Industrial Research, Chattogram. Bangladesh.

Ethnopharmacological Relevance: Saurauia roxburghii Wall. is an interesting plant, found growing chiefly along the eastern and south-eastern countries of Asia. The various ethnic groups of these regions use the plant as a medication for relieving a wide spectrum of diseases and conditions, including indigestion, boils, fever, gout, piles, eczema, asthma, ulcers, bronchitis, epilepsy, and hepatitis B. Read More

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http://dx.doi.org/10.2174/1389557520666200709175138DOI Listing

Management of interstitial lung diseases: A consensus statement of the Indian Chest Society (ICS) and National College of Chest Physicians (NCCP).

Lung India 2020 Jul-Aug;37(4):359-378

Department of Medicine, University of Washington, Seattle, USA.

Background: Interstitial lung disease (ILD) is a complex and heterogeneous group of acute and chronic lung diseases of several known and unknown causes. While clinical practice guidelines (CPG) for idiopathic pulmonary fibrosis (IPF) have been recently updated, CPG for ILD other than IPF are needed.

Methods: A working group of multidisciplinary clinicians familiar with clinical management of ILD (pulmonologists, radiologist, pathologist, and rheumatologist) and three epidemiologists selected by the leaderships of Indian Chest Society and National College of Chest Physicians, India, posed questions to address the clinically relevant situation. Read More

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http://dx.doi.org/10.4103/lungindia.lungindia_275_20DOI Listing

The clinical efficacy of AG NPP709 (Synatura) in patients with chronic bronchitis type stable chronic obstructive pulmonary disease.

J Thorac Dis 2020 May;12(5):2435-2442

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Background: AG NPP709 (Synatura) has been demonstrated to be efficacious in decreasing cough and sputum in patients with acute upper respiratory infection and chronic inflammatory bronchitis. The aim of this study was to evaluate the efficacy of AG NPP709 in patients with chronic bronchitis type chronic obstructive pulmonary disease (COPD).

Methods: This was a prospective, open-label, single-arm clinical trial (NCT03623282). Read More

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http://dx.doi.org/10.21037/jtd.2020.03.61DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330415PMC

Respiratory diseases and allergy in farmers working with livestock: a EAACI position paper.

Clin Transl Allergy 2020 6;10:29. Epub 2020 Jul 6.

Formerly Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.

Farmers constitute a large professional group worldwide. In developed countries farms tend to become larger, with a concentration of farm operations. Animal farming has been associated with negative respiratory effects such as work-related asthma and rhinitis. Read More

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http://dx.doi.org/10.1186/s13601-020-00334-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7336421PMC

Pathogenic characteristics of a QX-like infectious bronchitis virus strain SD in chickens exposed at different ages and protective efficacy of combining live homologous and heterologous vaccination.

Vet Res 2020 Jul 8;51(1):86. Epub 2020 Jul 8.

Key Laboratory of Animal Epidemiology of the Ministry of Agriculture, College of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian, Beijing, 100193, China.

Continued reports of infections with infectious bronchitis virus (IBV) variants have occurred since its first isolation in the 1930s. Currently, QX-like IBVs are the predominant circulating genotype around the world. Here, the pathogenicity of QX-like IBV strain SD was characterized in chickens at different ages of exposure to the virus, and the protection efficacy of available vaccine combinations against IBV was evaluated. Read More

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http://dx.doi.org/10.1186/s13567-020-00811-yDOI Listing

Quantitative Assessment of Regional Mucociliary Clearance in Smokers with Mild-to-Moderate Chronic Obstructive Pulmonary Disease and Chronic Bronchitis from Planar Radionuclide Imaging.

J Aerosol Med Pulm Drug Deliv 2020 Jul 8. Epub 2020 Jul 8.

Active Biotech, Lund, Sweden.

Mucociliary clearance (MCC) rate from the lung has been shown to be reduced in chronic obstructive pulmonary disease (COPD). This study investigates the value of regional clearance measurements in assessing MCC in mild-to-moderate disease. Measurement of lung MCC using planar gamma camera imaging was performed in three groups: (i) healthy nonsmoking controls (NSCs) ( = 9), (ii) smoking controls (SCs) who were current smokers with normal lung function ( = 10), and (iii) current smokers with mild-to-moderate COPD and bronchitis ( = 15). Read More

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http://dx.doi.org/10.1089/jamp.2019.1551DOI Listing

Titanium Dioxide Nanoparticles Exaggerate Respiratory Syncytial Virus-Induced Airway Epithelial Barrier Dysfunction.

Am J Physiol Lung Cell Mol Physiol 2020 Jul 8. Epub 2020 Jul 8.

Pediatric Pulmonology, Cleveland Clinic Children's; Cleveland Clinic Foundation, United States.

RSV is the leading cause of lower respiratory tract infections in children worldwide. While most develop a mild, self-limiting illness, some develop severe acute lower respiratory infection and persistent airway disease. Exposure to ambient particulate matter has been linked to asthma, bronchitis, and viral infection in multiple epidemiologic studies. Read More

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http://dx.doi.org/10.1152/ajplung.00104.2020DOI Listing

Whole-genome, transcriptome, and methylome analyses provide insights into the evolution of platycoside biosynthesis in , a medicinal plant.

Hortic Res 2020 1;7:112. Epub 2020 Jul 1.

Genomics Division, National Institute of Agricultural Sciences (NAS), Jeonju, 54874 Korea.

Triterpenoid saponins (TSs) are common plant defense phytochemicals with potential pharmaceutical properties. (Campanulaceae) has been traditionally used to treat bronchitis and asthma in East Asia. The oleanane-type TSs, platycosides, are a major component of the root extract. Read More

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http://dx.doi.org/10.1038/s41438-020-0329-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327020PMC

Incidence risk of bronchopneumonia in newborn calves associated with intrauterine diselementosis.

Vet World 2020 May 29;13(5):987-995. Epub 2020 May 29.

Laboratory of Environmental Biogeochemistry, V.I. Vernadsky Institute of Geochemistry and Analytical Chemistry, Moscow, Russia.

Background And Aim: Macro- and micro-elements are required to ensure the normal course of biochemical processes in the development of an animal's body. Any excess, deficiency, or imbalance in chemical elements in an animal's body can cause the development of various latent or clinically expressed pathological conditions. Diselementosis in pregnant cows may lead to impaired embryo and fetal development, as well as reduced neonatal viability. Read More

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http://dx.doi.org/10.14202/vetworld.2020.987-995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311866PMC

Standardized Extract of Atractylodis Rhizoma Alba and Fructus Schisandrae Ameliorates Coughing and Increases Expectoration of Phlegm.

Molecules 2020 Jul 4;25(13). Epub 2020 Jul 4.

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 1, Gwanak-ro, Gwanak-gu, Seoul 08826, Korea.

Cough and phlegm frequently occur in respiratory diseases like upper respiratory tract infections, acute bronchitis, and chronic obstructive pulmonary diseases. To relieve these symptoms and diseases, various ingredients are being used despite the debates on their clinical efficacy. We aimed to investigate the effects of the extract CKD-497, composed of Atractylodis Rhizoma Alba and Fructus Schisandrae, in relieving cough and facilitating expectoration of phlegm. Read More

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http://dx.doi.org/10.3390/molecules25133064DOI Listing

Flexible Bronchoscopy in Evaluation of Persistent Wheezing in Children-Experiences from National Pediatric Center.

Medicina (Kaunas) 2020 Jul 2;56(7). Epub 2020 Jul 2.

Department of Pulmonology, Mother and Child Health Institute of Serbia, 11000 Belgrade, Serbia.

Persistent wheezing (PW) is defined as prolonged or recurrent episodes of wheezing despite regular treatment. Flexible bronchoscopy (FB) is recommended to determine the etiology of PW in children. This study aimed to determine the etiology of PW based on FB findings in a national pediatric center. Read More

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http://dx.doi.org/10.3390/medicina56070329DOI Listing

Prevalence of food allergen and aeroallergen sensitization among children in Sichuan province.

Medicine (Baltimore) 2020 Jul;99(27):e21055

Department of Laboratory Medicine, West China Second University Hospital, and Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education.

Food allergen and aeroallergen sensitization are common allergic diseases worldwide, with widely varying estimates of prevalence in children. Our study investigated the characteristics of ingestion and inhalation allergy among children from Sichuan province in Southwest China, so as to get public awareness of these disorders.A total of 1722 children between 0 and 14 years' old were enrolled in this study. Read More

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http://dx.doi.org/10.1097/MD.0000000000021055DOI Listing

Investigations and management of chronic cough: update from the European Respiratory Society Chronic Cough Taskforce 2020.

Pol Arch Intern Med 2020 Jul 6. Epub 2020 Jul 6.

Chronic cough affects approximately 10% of general population, is highest amongst people aged 50-60, and is twice as common in women than men. It is described to last 8 weeks or longer in adults and not treated effectively with most over-the-counter medications. This is a debilitating condition with physical, social, and psychological consequences. Read More

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http://dx.doi.org/10.20452/pamw.15484DOI Listing

Emerging infectious bronchitis virus (IBV) in Egypt: Evidence for an evolutionary advantage of a new S1 variant with a unique gene 3ab constellation.

Infect Genet Evol 2020 Jul 1:104433. Epub 2020 Jul 1.

Institute of Diagnostic Virology Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Germany. Electronic address:

Infectious bronchitis virus (IBV), a gamma-coronavirus, causes infectious bronchitis (IB), a major respiratory disease of chicken. Its high mutation rate in conjunction with recombination of the RNA genome constantly creates IBV variants that are difficult to control by currently available vaccines. In this study, we addressed the question whether small-scale holdings might harbor IBV variants that serve as a reservoir for newly emerging variants. Read More

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http://dx.doi.org/10.1016/j.meegid.2020.104433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327463PMC

Molecular Monitoring of D1466 Genotype of Avian Infectious Bronchitis Virus in Iran: A Retrospective Study in 2013-2017.

Arch Razi Inst 2020 Jun 1;75(2):163-168. Epub 2020 Jun 1.

Iranian Veterinary Organization, Tehran, Iran.

Infectious bronchitis is one of the most common diseases in the poultry industry in many countries, especially in the regions with a dense poultry farming industry. Gammacoronavirus is the etiologic agent of this disease, with the chickens and poultries as the natural reservoirs of the virus. Various strains of infectious bronchitis virus have been reported in poultry around the world. Read More

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http://dx.doi.org/10.22092/ari.2018.121512.1214DOI Listing

Molecular Detection of Avian Infectious Bronchitis Viruses in Live Bird Markets, Gilan Province.

Arch Razi Inst 2020 Jun 1;75(2):155-162. Epub 2020 Jun 1.

Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.

Coronaviruses (AvCoV) which include infectious bronchitis virus (IBV) and other bird coronaviruses belong to the genus gammacoronavirus, subfamily Coronavirinae. One of the most prominent representatives of gammacoronavirus genus is infectious bronchitis virus (IBV) which is a highly contagious viral pathogen of chickens causing considerable economic losses to the poultry industry. IBVs mostly affect the respiratory, urinary, and reproductive tracts leading to a substantial drop in production. Read More

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http://dx.doi.org/10.22092/ari.2018.122702.1226DOI Listing

Effects of different mating strategies in broiler breeder during peak and postpeak phase on subsequent broiler performance.

Poult Sci 2020 Jul 17;99(7):3501-3510. Epub 2020 Apr 17.

Department of Theriogenology, Faculty of Veterinary Science, University of Veterinary and Animal Sciences, Lahore, Pakistan.

Two experimental trials on commercial broiler (Ross-308) were conducted to evaluate the carryover effect of artificial insemination (AI) in parent flock (PF) kept in cages (C), and on floor (F) in comparison to natural mating (NM) in floored PF. A total of 900 broiler chicks were obtained from 38-week-old PF (peak production), representing C, F, and NM evenly during first trial, whereas in second trial, similar number of chicks were obtained from same PF during postpeak phase (55 wk of age). Subsequent effects of AI and NM in PF were evaluated by bacteriology, posthatch mortality, growth performance, immune response, and carcass traits on experimental birds (broiler). Read More

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http://dx.doi.org/10.1016/j.psj.2020.03.038DOI Listing

Effects of supplementing yeast fermentate in the feed or drinking water on stress susceptibility, plasma chemistry, cytokine levels, antioxidant status, and stress- and immune-related gene expression of broiler chickens.

Poult Sci 2020 Jul 18;99(7):3312-3318. Epub 2020 Apr 18.

Department of Poultry Science, Texas A&M University, College Station, TX, USA 77843. Electronic address:

This study aimed to elucidate the mechanism by which adding Saccharomyces cerevisiae-derived yeast fermentate to the feed (XPC) or drinking water reduces stress in poultry. Day-old male Cobb 500 broiler chicks were assigned to 1 of 3 treatments: stressed control (CS), stressed + XPC (1.25 kg/metric ton feed, day 0-43; XPC), or stressed + AviCare (160 mL/100 L drinking water, day 0-43; AVI). Read More

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http://dx.doi.org/10.1016/j.psj.2020.03.037DOI Listing

Smoking Behaviors in Survivors of Smoking-Related and Non-Smoking-Related Cancers.

JAMA Netw Open 2020 Jul 1;3(7):e209072. Epub 2020 Jul 1.

Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston.

Importance: The population of cancer survivors is rapidly growing in the US. Tobacco smoking is associated with many cancers; however, whether cigarette smoking behaviors among cancer survivors vary according to cancer type-that is, smoking-related cancers (SRCs) vs non-smoking-related cancers (NSRCs)-remains unclear.

Objectives: To examine cigarette smoking prevalence and behaviors (ie, continuing or quitting smoking) among cancer survivors and to compare them between survivors of SRCs and NSRCs. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.9072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333020PMC

Sputum Inflammometry to Manage Chronic Obstructive Pulmonary Disease Exacerbations: Beyond Guidelines.

Tuberc Respir Dis (Seoul) 2020 Jul 18;83(3):175-184. Epub 2020 Jun 18.

Firestone Institute for Respiratory Health, St. Joseph's Healthcare Hamilton and the Department of Medicine, McMaster University, Hamilton, ON, Canada.

Quantitative sputum cytometry facilitates in assessing the nature of bronchitis associated with exacerbations of chronic obstructive pulmonary disease (COPD). This is not assessed in most clinical trials that evaluate the effectiveness of strategies to prevent or to treat exacerbations. While up to a quarter of exacerbations may be associated with raised eosinophil numbers, the vast majority of exacerbations are associated with neutrophilic bronchitis that may indicate airway infections. Read More

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http://dx.doi.org/10.4046/trd.2020.0033DOI Listing

Obesity and Morbidity Risk in the U.S. Veteran.

Healthcare (Basel) 2020 Jun 29;8(3). Epub 2020 Jun 29.

School of Health Administration, Texas State University, San Marcos, TX 78666, USA.

The obesity epidemic in the United States has been well documented and serves as the basis for a number of health interventions across the nation. However, those who have served in the U.S. Read More

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http://dx.doi.org/10.3390/healthcare8030191DOI Listing

[Acute respiratory distress in a frail older patient: spontaneous tooth aspiration].

Ned Tijdschr Tandheelkd 2020 May;127(5):282-285

A 68-year-old man presented at the emergency room with acute difficulty breathing. On account of recent subarachnoidal haemorrhage the patient was a resident of a care facility, and was also being treated for acute bronchitis there. Radiographic imaging of the lungs revealed a tooth with crown and pontic to have been inhaled. Read More

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http://dx.doi.org/10.5177/ntvt.2020.05.19132DOI Listing

Reply to: Understanding the Role of Regulatory T Cells in Non-asthmatic Eosinophilic Bronchitis.

Lung 2020 Jun 30. Epub 2020 Jun 30.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, 151 Yanjiang Road, Guangzhou, 510120, Guangdong, China.

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http://dx.doi.org/10.1007/s00408-020-00373-yDOI Listing

Understanding the Role of Regulatory T Cells in Non-asthmatic Eosinophilic Bronchitis.

Authors:
Sachin Ananth

Lung 2020 Jun 30. Epub 2020 Jun 30.

Department of Respiratory Medicine, West Hertfordshire Hospital NHS Trust, Watford, WD18 0HB, UK.

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http://dx.doi.org/10.1007/s00408-020-00372-zDOI Listing

Effectiveness and Tolerability of LABA/LAMA Fixed-Dose Combinations Aclidinium/Formoterol, Glycopyrronium/Indacaterol and Umeclidinium/Vilanterol in the Treatment of COPD in Daily Practice - Results of the Non-Interventional DETECT Study.

Int J Chron Obstruct Pulmon Dis 2020 10;15:1335-1347. Epub 2020 Jun 10.

Insaf - Respiratory Research Institute GmbH, Wiesbaden, Germany.

Background: LABA (long-acting β2-agonists) and/or LAMA (long-acting muscarinic antagonists) represent the first treatment options for patients with symptomatic COPD. Although both display different mechanisms of activity, in combination they have a stronger broncho-dilating effect than monotherapy; hence, a combination of both LABA and LAMA is particularly recommended for patients whose symptoms cannot be sufficiently improved by a single active ingredient. To date, only few data have been collected regarding the therapeutic outcomes of approved LABA/LAMA fixed-dose combinations (FDCs) under everyday (real-life) conditions in non-clinical trial settings. Read More

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http://dx.doi.org/10.2147/COPD.S252354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293910PMC

Comparative Protective Efficacies of Novel Avian Paramyxovirus-Vectored Vaccines against Virulent Infectious Bronchitis Virus in Chickens.

Viruses 2020 Jun 28;12(7). Epub 2020 Jun 28.

Virginia-Maryland College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA.

Viral vectored vaccines are desirable alternatives for conventional infectious bronchitis virus (IBV) vaccines. We have recently shown that a recombinant Newcastle disease virus (rNDV) strain LaSota expressing the spike (S) protein of IBV strain Mass-41 (rLaSota/IBV-S) was a promising vaccine candidate for IBV. Here we evaluated a novel chimeric rNDV/avian paramyxovirus serotype 2 (rNDV/APMV-2) as a vaccine vector against IBV. Read More

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http://dx.doi.org/10.3390/v12070697DOI Listing

Role of Mucolytics in the Treatment of Chronic Bronchitis or COPD.

Am Fam Physician 2020 Jul;102(1):16-17

Fort Belvoir Community Hospital, For Belvoir, VA, USA.

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Social vulnerabilities of female waste pickers in Brasília, Brazil.

Arch Environ Occup Health 2020 Jun 30:1-8. Epub 2020 Jun 30.

Faculty of Ceilândia, Public Health, University of Brasília, Brasilia, Brazil.

Worldwide, waste pickers are exposed to adverse health effects resulting from hazards at work. This study aimed to identify possible gender disparities among waste pickers. A quantitative cross-sectional epidemiological study, using semi-structured data was conducted in 's dumpsite, Brasília, Brazil. Read More

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http://dx.doi.org/10.1080/19338244.2020.1787315DOI Listing

Establishment of a mouse model with all four clinical features of eosinophilic bronchitis.

Sci Rep 2020 Jun 29;10(1):10557. Epub 2020 Jun 29.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University (Guangzhou Medical University), No. 151 Yanjiang Road, Yuexiu District, Guangzhou, 510120, Guangdong, China.

Eosinophilic bronchitis (EB) is a clinical disease characterized by chronic cough, airway eosinophil infiltration, and responsive to steroid therapy but with the absence of airway hyperreactivity (AHR). This study established an EB mouse model with all the above features. First, 42 mice were divided into 7 groups to investigate the optimal time interval between cough and AHR detections. Read More

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http://dx.doi.org/10.1038/s41598-020-67475-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324364PMC

Prevalence and risk factors of small airway dysfunction, and association with smoking, in China: findings from a national cross-sectional study.

Lancet Respir Med 2020 Jun 26. Epub 2020 Jun 26.

Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China; WHO Collaborating Center for Tobacco Cessation and Respiratory Diseases Prevention, Beijing, China; National Clinical Research Center for Respiratory Diseases, Beijing, China; Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Beijing, China; Beijing Chao-Yang Hospital, Department of Respiratory Medicine, Capital Medical University, Beijing, China. Electronic address:

Background: Small airway dysfunction is a common but neglected respiratory abnormality. Little is known about its prevalence, risk factors, and prognostic factors in China or anywhere else in the world. We aimed to estimate the prevalence of small airway dysfunction using spirometry before and after bronchodilation, both overall and in specific population subgroups; assess its association with a range of lifestyle and environmental factors (particularly smoking); and estimate the burden of small airway dysfunction in China. Read More

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http://dx.doi.org/10.1016/S2213-2600(20)30155-7DOI Listing

[A clinical case of visceral toxocariasis as a cause of eosinophilic polyserositis].

Ter Arkh 2019 Nov 15;91(11):66-71. Epub 2019 Nov 15.

Nesterov Department of Faculty Therapy Pirogov Russian National Research Medical University.

The aim of the present report is to describe a clinical case of toxocariasis. 37-year - old man was admitted to Pirogov Municipal Clinical Hospital No.1 in Moscow. Read More

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http://dx.doi.org/10.26442/00403660.2019.11.000314DOI Listing
November 2019

[Non - tuberculous mycobacteriosis of the lungs - diagnostic possibilities in the practice of the pulmonologist].

Ter Arkh 2019 Nov 15;91(11):26-31. Epub 2019 Nov 15.

Central TB Research Institute.

Aim Of The Study: Show the possibilities of diagnosing non - tuberculous mycobacteriosis of the lungs (NTML) in the practice of the pulmonologist.

Materials And Methods: A survey of 90 patients with a confirmed diagnosis of non - tuberculous mycobacteriosis of the lungs (NTML) was presented. The diagnosis of pulmonary mycobacteriosis was established in accordance with the criteria proposed in 2007 by the American Thoracic Society and the American Society of Infectious Diseases (ATS/IDRS). Read More

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http://dx.doi.org/10.26442/00403660.2019.11.000306DOI Listing
November 2019

Exhaled carbon monoxide levels in infants and toddlers with episodic asthma.

Fukushima J Med Sci 2020 Jun 27. Epub 2020 Jun 27.

Department of Pediatrics, Fukushima Medical University.

Objective: There are few lung function tests available to evaluate bronchial asthma in infants and toddlers. The objective of this study was to test the hypothesis that the measurement of exhaled carbon monoxide (eCO) levels is applicable to evaluate infants and toddlers with stable asthma and during acute asthma attack.

Methods: A one-way valve breath sampling bag was developed to collect the exhaled air of infants and toddlers. Read More

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http://dx.doi.org/10.5387/fms.2019-02DOI Listing

Construction of a hybrid lung model by combining a real geometry of the upper airways and an idealized geometry of the lower airways.

Comput Methods Programs Biomed 2020 Jun 20;196:105613. Epub 2020 Jun 20.

Facultad de Enfermería, Universidad de Oviedo, Instituto Nacional de Silicosis and GRUBIPU-ISPA, Spain. Electronic address:

Background And Objective: Health care costs represent a substantial an increasing percentage of global expenditures. One key component is treatment of respiratory diseases, which account for one in twelve deaths in Europe. Computational simulations of lung airflow have potential to provide considerable cost reduction and improved outcomes. Read More

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http://dx.doi.org/10.1016/j.cmpb.2020.105613DOI Listing

A Prospective Safety and Feasibility Study of Metered CryoSpray (MCS) for Patients with Chronic Bronchitis in COPD.

Eur Respir J 2020 Jul 2. Epub 2020 Jul 2.

Royal Brompton Hospital, London, UK

Background: No currently approved intervention counteracts airway metaplasia and mucus hypersecretion of Chronic Bronchitis (CB) in COPD. Metered Cryospray (MCS) delivering liquid nitrogen (LN) to the tracheobronchial airways ablates abnormal epithelium and facilitates healthy mucosal regeneration. The objective of this study was to evaluate the feasibility, efficacy and safety of MCS in CB. Read More

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http://dx.doi.org/10.1183/13993003.00556-2020DOI Listing

Modeling Healthcare Costs Attributable to Secondhand Smoke Exposure at Home among South Korean Children.

Int J Environ Res Public Health 2020 Jun 23;17(12). Epub 2020 Jun 23.

College of Pharmacy, Ewha Womans University, Seoul 03760, Korea.

Children exposed to secondhand smoke (SHS) are at increased risk for disease. We sought to estimate the medical costs among Korean children who were exposed to SHS at home. A Markov model was developed, including five diseases (asthma, acute otitis media, acute bronchitis, pneumonia and sudden infant death syndrome) that were significantly associated with SHS in children based on a systematic review. Read More

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http://dx.doi.org/10.3390/ijerph17124496DOI Listing

Development and validation of a bronchoscopically defined bronchitis scoring tool in children.

Pediatr Pulmonol 2020 Jun 25. Epub 2020 Jun 25.

Department of Respiratory and Sleep Medicine, Queensland Children's Hospital, Brisbane, Queensland, Australia.

Introduction/aim: A validated tool for scoring bronchitis during flexible bronchoscopy (FB) is potentially useful for clinical practice and research. We aimed to develop a bronchoscopically defined bronchitis scoring system in children (BScore) based on our pilot study.

Methods: Children undergoing FB were prospectively enrolled. Read More

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http://dx.doi.org/10.1002/ppul.24924DOI Listing

A Functional Respiratory Imaging Approach to the Effect of an Oscillating Positive Expiratory Pressure Device in Chronic Obstructive Pulmonary Disease.

Int J Chron Obstruct Pulmon Dis 2020 4;15:1261-1268. Epub 2020 Jun 4.

Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Wilrijk, Belgium.

Purpose: Chronic obstructive pulmonary disease (COPD) patients are prone to suffer from chronic bronchitis, which ultimately affects their quality of life and overall prognosis. Oscillating positive expiratory pressure (oPEP) devices are designed to aid in the mucus clearance by generating positive pressure pulses in the airways. The main aim of this study was to analyze the impact of a specific oPEP device - Aerobika - on top of standard of care medication in COPD patients' lung dynamics and drug deposition. Read More

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http://dx.doi.org/10.2147/COPD.S242191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280059PMC

Nitric Oxide Production and Fc Receptor-Mediated Phagocytosis as Functional Readouts of Macrophage Activity upon Stimulation with Inactivated Poultry Vaccines In Vitro.

Vaccines (Basel) 2020 06 22;8(2). Epub 2020 Jun 22.

Department of Biomolecular Health Sciences, Division of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 1, 3584CL Utrecht, The Netherlands.

Vaccine batches must pass routine quality control to confirm that their ability to induce protection against disease is consistent with batches of proven efficacy from development studies. For poultry vaccines, these tests are often performed in laboratory chickens by vaccination-challenge trials or serological assays. The aim of this study was to investigate innate immune responses against inactivated poultry vaccines and identify candidate immune parameters for in vitro quality tests as alternatives for animal-based quality tests. Read More

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http://dx.doi.org/10.3390/vaccines8020332DOI Listing

Infectious Bronchitis Virus Evolution, Diagnosis and Control.

Vet Sci 2020 Jun 22;7(2). Epub 2020 Jun 22.

Department of Animal Medicine, Production and Health, University of Padua, Viale dell'Università, 16, 35020 Legnaro, Italy.

RNA viruses are characterized by high mutation and recombination rates, which allow a rapid adaptation to new environments. Most of the emerging diseases and host jumps are therefore sustained by these viruses. Rapid evolution may also hinder the understanding of molecular epidemiology, affect the sensitivity of diagnostic assays, limit the vaccine efficacy and favor episodes of immune escape, thus significantly complicating the control of even well-known pathogens. Read More

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http://dx.doi.org/10.3390/vetsci7020079DOI Listing

Limited Cross-Protection against Infectious Bronchitis Provided by Recombinant Infectious Bronchitis Viruses Expressing Heterologous Spike Glycoproteins.

Vaccines (Basel) 2020 Jun 22;8(2). Epub 2020 Jun 22.

The Pirbright Institute, Pirbright, Surrey GU24 0NF, UK.

infectious bronchitis virus (IBV) causes an economically important respiratory disease of poultry. Protective immunity is associated with the major structural protein, spike (S) glycoprotein, which induces neutralising antibodies and defines the serotype. Cross-protective immunity between serotypes is limited and can be difficult to predict. Read More

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http://dx.doi.org/10.3390/vaccines8020330DOI Listing

Biomarkers of Oxidative Stress and Inflammation in Chronic Airway Diseases.

Int J Mol Sci 2020 Jun 18;21(12). Epub 2020 Jun 18.

Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, 37134 Verona, Italy.

Introduction: The global burden of chronic airway diseases represents an important public health concern. The role of oxidative stress and inflammation in the pathogenesis of these diseases is well known. The aim of this study is to evaluate the behavior of both inflammatory and oxidative stress biomarkers in patients with chronic bronchitis, current asthma and past asthma in the frame of a population-based study. Read More

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http://dx.doi.org/10.3390/ijms21124339DOI Listing

How does one choose the appropriate pharmacotherapy for children with lower respiratory tract infections?

Expert Opin Pharmacother 2020 Jun 21:1-9. Epub 2020 Jun 21.

Università degli Studi di Milano , Milan, Italy.

Introduction: The definition of acute lower respiratory tract infection (LRTI) includes any infection involving the respiratory tract below the level of the larynx. In children, the most common acute LRTIs, and those with the greatest clinical relevance, are community-acquired pneumonia (CAP), bronchiolitis, bronchitis and tuberculosis (TB). The clinical relevance of LRTIs implies that they must be addressed with the most effective therapy. Read More

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http://dx.doi.org/10.1080/14656566.2020.1781091DOI Listing

Novel SARS-CoV-2/COVID-19: Origin, pathogenesis, genes and genetic variations, immune responses and phylogenetic analysis.

Gene Rep 2020 Sep 15;20:100752. Epub 2020 Jun 15.

Department of Breeding and Genetics, Cholistan University of Veterinary and Animal Sciences, Bahawalpur, Pakistan.

In this review, we focused on the origins of the novel coronavirus (SARS-CoV-2), origin, pathogenesis, immune responses, genes and genetic variations, phylogenetic analyses, and potential therapeutic strategies to summarize approaches for developing broadly effective preventions and vaccines to cope COVID-19. Towards the end of 2019, SARS-CoV-2 has emerged in association with the SARS, later was named COVID-19 caused an environment of chaos worldwide and infected a massive number of lives. Since these epidemics or pandemics had spread to 210 countries and territories around the world and 2 international conveyances with 6,467,229 confirmed cases, including, 382,766 deaths, as of June 03, 2020 (https://www. Read More

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http://dx.doi.org/10.1016/j.genrep.2020.100752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295489PMC
September 2020

Bioactivity-guided isolation of anti-inflammatory components from .

Food Sci Nutr 2020 Jun 22;8(6):2670-2679. Epub 2020 Apr 22.

Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods Guangdong Research Center for Engineering Technology in Bioactive Natural Products College of Food Science South China Agricultural University Guangzhou China.

() is a traditionally edible fruit that is good for treatment of biliary diseases, bronchitis, etc. It has obvious anti-inflammatory activity, but few studies focus on its anti-inflammatory active substance basis. The purpose of this study was to explore the material basis of anti-inflammatory activity of  , purify, and identify anti-inflammatory active monomers. Read More

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http://dx.doi.org/10.1002/fsn3.1553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7300070PMC

Study design and baseline characteristics of Shenzhen ageing-related disorder cohort in China.

BMJ Open 2020 Jun 21;10(6):e034317. Epub 2020 Jun 21.

Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Subject of Health Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, China

Purpose: The Shenzhen ageing-related disorder cohort was designed to detect the associations of lifestyle, environmental and genetic factors with major ageing-related disorders, especially neurological and mental disorders.

Participants: The cohort was a community-dwelling prospective study of 9411 elderly adults aged 60 to 92 years from 51 community health service centres in Luohu district of Shenzhen, China. The baseline data were collected between 2017 and 2018, including demographics and socioeconomics, lifestyles, medical history, family history of major non-communicable chronic disease, environmental exposures, clinical analysis of blood and urine, clinical imaging measurements, anthropometric measures and neurological function and mental health assessments. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-034317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307537PMC

Vaccination against coronaviruses in domestic animals.

Authors:
Ian R Tizard

Vaccine 2020 07 10;38(33):5123-5130. Epub 2020 Jun 10.

Department of Veterinary Pathobiology, Texas A&M University, College Station, TX 77843, United States. Electronic address:

The current pandemic of COVID-19 has set off an urgent search for an effective vaccine. This search may well benefit from the experiences of the animal health profession in the development and use of coronavirus vaccines in domestic animal species. These animal vaccines will in no way protect humans against COVID-19 but knowledge of the difficulties encountered in vaccinating animals may help avoid or minimize similar problems arising in humans. Read More

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http://dx.doi.org/10.1016/j.vaccine.2020.06.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284272PMC

Epidemiological characteristics of respiratory viruses in patients with acute respiratory infections during 2009-2018 in southern China.

Int J Infect Dis 2020 Jun 17. Epub 2020 Jun 17.

Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-sen University, Guangzhou, China; Research Center for Clinical Laboratory Standard, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China; Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. Electronic address:

Background: Acute respiratory infections (ARIs) remain a major public threat with high morbidity and mortality all over the world, and viruses are important pathogens that cause ARIs. This work is conducted to better understand the epidemiological characteristics of respiratory viruses circulating in southern China.

Methods: Totally 22,680 respiratory samples were collected from ARI patients from 18 hospitals in southern China during 2009-2018, and seven common respiratory viruses including Flu, RSV, PIV, hMPV, ADV, HCoV and HBoV were screened using in-house real-time PCR. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.06.051DOI Listing