39,217 results match your criteria Bronchitis


Second-hand smoke exposure in adulthood and lower respiratory health during 20 year follow up in the European Community Respiratory Health Survey.

Respir Res 2019 Feb 14;20(1):33. Epub 2019 Feb 14.

Institute of Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.

Background: Early life exposure to tobacco smoke has been extensively studied but the role of second-hand smoke (SHS) for new-onset respiratory symptoms and lung function decline in adulthood has not been widely investigated in longitudinal studies. Our aim is to investigate the associations of exposure to SHS in adults with respiratory symptoms, respiratory conditions and lung function over 20 years.

Methods: We used information from 3011 adults from 26 centres in 12 countries who participated in the European Community Respiratory Health Surveys I-III and were never or former smokers at all three surveys. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-019-0996-zDOI Listing
February 2019
1 Read

Acid diterpenes from Copaiba oleoresin (Copaifera langsdorffii): Chemical and plasma stability and intestinal permeability using Caco-2 cells.

J Ethnopharmacol 2019 Feb 11;235:183-189. Epub 2019 Feb 11.

São Paulo State University (UNESP), School of Pharmaceutical Sciences, Araraquara, SP ZIP 14801-902, Brazil. Electronic address:

Ethnopharmacological Relevance: Copaiba oleoresin has been used in folk medicine in the treatment of bronchitis, syphilis, skin diseases and ulcers due to its anti-inflammatory and antiseptic activities, but there is no information about major compounds oral absorption to support the traditional use.

Aim Of Study: Considering the potential of copalic (CA) and kaurenoic acid (KA) - major biological activity (in vitro) diterpenes found in the oleoresin, this study aimed to evaluate the intestinal permeability of CA and KA using Caco-2 cells model as predictive test for oral drug absorption.

Materials And Methods: Chemical stability at pH 1. Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.017DOI Listing
February 2019

Immunoprofiling of peripheral blood from infectious bronchitis virus vaccinated MHC-B chicken lines - Monocyte MHC-II expression as a potential correlate of protection.

Dev Comp Immunol 2019 Feb 11. Epub 2019 Feb 11.

Department of Animal Science, Aarhus University, Blichers Allé 20, 8830, Tjele, Denmark. Electronic address:

Vaccination programs are implemented in poultry farms to limit outbreaks and spread of infectious bronchitis virus (IBV), which is a substantial economic burden in the poultry industry. Immune correlates, used to predict vaccine efficacy, have proved difficult to find for IBV-vaccine-induced protection. To find correlates of IBV-vaccine-induced protection, hence, we employed a flow cytometric assay to quantify peripheral leucocyte subsets and expression of cell surface markers of six different non-vaccinated and vaccinated Major Histocompatibility Complex (MHC) haplotypes. Read More

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http://dx.doi.org/10.1016/j.dci.2019.02.004DOI Listing
February 2019

Prevalence and characteristics of acute respiratory virus infections in pediatric cancer patients.

J Med Virol 2019 Feb 14. Epub 2019 Feb 14.

Department of Experimental Pathology, Immunology and Microbiology.

Background: Pediatric cancer patients have a higher risk of morbidity and mortality due to respiratory viral infections than do other patient populations.

Objectives: To investigate the causative viruses of respiratory infections and their burden among pediatric cancer patients in Lebanon.

Study Design: Nasopharyngeal swabs along with clinical and demographic data were collected from pediatric cancer patients presenting febrile episodes with upper respiratory tract symptoms. Read More

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http://doi.wiley.com/10.1002/jmv.25432
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http://dx.doi.org/10.1002/jmv.25432DOI Listing
February 2019
1 Read

Genetic and antigenic heterogeneity of infectious bronchitis virus in South America: implications for control programs.

Avian Pathol 2019 Feb 14:1-28. Epub 2019 Feb 14.

a Sección Genética Evolutiva, Instituto de Biología, Facultad de Ciencias , Universidad de la República , Iguá 4225, 11400 Montevideo , Uruguay.

Infectious bronchitis virus (IBV) is a persistent sanitary problem for the South American poultry industry despite extensive vaccination. The IBV single-stranded RNA genome has high rates of mutation and recombination that generate a notorious virus variability. Since most IBV vaccines are type-specific, there is a need for a constant surveillance of the circulating lineages and knowledge about their genetic and antigenic properties. Read More

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https://www.tandfonline.com/doi/full/10.1080/03079457.2019.1
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http://dx.doi.org/10.1080/03079457.2019.1583315DOI Listing
February 2019
1 Read

The Effect of Chronic Exposure to Flour Dust on Pulmonary Functions.

Int J Occup Saf Ergon 2019 Feb 14:1-19. Epub 2019 Feb 14.

e Vice-chancellery of Health , Lorestan University of Medical Sciences , Lorestan , Iran.

Purpose: This study aimed to examine the effect of chronic exposure to flour dust on the pulmonary symptoms and pulmonary indices of mill workers.

Materials And Methods: This cohort study was conducted on 67 mill workers and 53 controls from 2014 to 2016. Demographic information was collected through interviews, and pulmonary indices; and flour dust exposure was measured by spirometry, and NIOSH 0500 and NIOSH 0600 methods. Read More

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http://dx.doi.org/10.1080/10803548.2019.1582853DOI Listing
February 2019

Phosphodiesterases As Therapeutic Targets for Respiratory Diseases.

Pharmacol Ther 2019 Feb 10. Epub 2019 Feb 10.

Department of Molecular Pharmacology, University of Groningen, The Netherlands;; Groningen Research Institute for Asthma and COPD, GRIAC, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) and asthma, affect millions of people all over the world. Cyclic adenosine monophosphate (cAMP) which is one of the most important second messengers, plays a vital role in relaxing airway smooth muscles and suppressing inflammation. Given its vast role in regulating intracellular responses, cAMP provides an attractive pharmaceutical target in the treatment of chronic respiratory diseases. Read More

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http://dx.doi.org/10.1016/j.pharmthera.2019.02.002DOI Listing
February 2019

Bringing Light to Chronic Obstructive Pulmonary Disease Pathogenesis and Resilience.

Authors:
Rubin M Tuder

Ann Am Thorac Soc 2018 Dec;15(Supplement_4):S227-S233

Program in Translational Lung Research and Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado.

The pathogenesis of chronic obstructive pulmonary disease remains elusive; investigators in the field have struggled to decipher the cellular and molecular processes underlying chronic bronchitis and emphysema. Studies in the past 20 years have underscored that the tissue destruction, notably in emphysema, involves a multitude of injurious stresses, with progressive engagement of endogenous destructive processes triggered by decades of exposure to cigarette smoke and/or pollutants. These lead to an aged lung, with evidence of macromolecular damage that is unlikely to repair. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201808-583MGDOI Listing
December 2018
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Functional Studies of Single-Nucleotide Polymorphisms Suggest Heterogeneity in Chronic Obstructive Pulmonary Disease due to Susceptibility of Different Cell Types.

Ann Am Thorac Soc 2018 Dec;15(Supplement_4):S285

2 Brigham and Women's Hospital, Boston Massachusetts.

Chronic obstructive pulmonary disease (COPD) is a syndrome that comprises several lung pathologies, but subphenotyping the various disease subtypes has not been successful. We found that a single-nucleotide polymorphism (SNP) within the proline-rich domain of transformation-related protein 53 (TP53) that modifies Pro72 to Arg is associated with twofold increased risk for chronic bronchitis in the Lovelace Smokers and COPDGene cohorts. This association is pronounced for those who report either wood smoke, dust, or fumes exposure. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201806-437MGDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6322001PMC
December 2018

Generation of Alpha-1 Antitrypsin Knockout and PI*ZZ Ferrets Using Crispr/Cas9. A Genetic Model of Emphysema.

Ann Am Thorac Soc 2018 Dec;15(Supplement_4):S292-S293

1 Department of Anatomy and Cell Biology and.

Rationale: The most prevalent genetic cause of chronic obstructive pulmonary disease is alpha-1 antitrypsin (A1AT) deficiency, a disorder that has yet to be widely modeled in animals because of species-specific differences between rodents and humans.

Objectives: To address these challenges, we engineered two A1AT ferret models using zygote gene editing to test the hypothesis that unopposed protease activity within the lung leads to emphysema and bronchitis.

Methods: Guide RNAs targeting exon 2 (for knockout) and exon 5 (for Z-allele mutation, Pi*Z) of the ferret A1AT gene were injected into ferret zygotes with Cas9 mRNA. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201806-429MGDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321996PMC
December 2018

Risk of COPD due to indoor air pollution from biomass cooking fuel: a systematic review and meta-analysis.

Int J Environ Health Res 2019 Feb 13:1-14. Epub 2019 Feb 13.

b Department of Pulmonary, Critical Care and Sleep Medicine , Safdarjang Hospital and VMMC College, Guru Gobind Singh Indraprastha University , New Delhi , India.

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of mortality in developing nations. In this meta-analysis, we aimed to determine the association between indoor air pollution and risk of COPD. Database searches were conducted using indoor air pollution, biomass and COPD related terms to identify relevant articles. Read More

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http://dx.doi.org/10.1080/09603123.2019.1575951DOI Listing
February 2019

Development of a recombinant Newcastle disease virus-vectored vaccine for infectious bronchitis virus variant strains circulating in Egypt.

Vet Res 2019 Feb 11;50(1):12. Epub 2019 Feb 11.

Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, MD, USA.

Infectious bronchitis virus (IBV) causes a major disease problem for the poultry industry worldwide. The currently used live-attenuated vaccines have the tendency to mutate and/or recombine with circulating field strains resulting in the emergence of vaccine-derived variant viruses. In order to circumvent these issues, and to develop a vaccine that is more relevant to Egypt and its neighboring countries, a recombinant avirulent Newcastle disease virus (rNDV) strain LaSota was constructed to express the codon-optimized S glycoprotein of the Egyptian IBV variant strain IBV/Ck/EG/CU/4/2014 belonging to GI-23 lineage, that is prevalent in Egypt and in the Middle East. Read More

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https://veterinaryresearch.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13567-019-0631-5DOI Listing
February 2019
7 Reads

The 3D8 single chain variable fragment protein suppress infectious bronchitis virus transmission in the transgenic chickens.

Res Vet Sci 2019 Jan 23;123:293-297. Epub 2019 Jan 23.

Animal Biotechnology Division, National Institute of Animal Science, Rural Development Administration, 1500, Wanju-gun 441-706, Republic of Korea. Electronic address:

Infectious bronchitis (IB) generated by the infectious bronchitis virus (IBV) causes economic difficulties for livestock farmers. The 3D8 single chain variable fragment (scFv) protein is a recombinant antibody with nuclease activity that shows antiviral effects against various DNA and RNA viruses in mice and chickens. In this experiment, 3D8 scFv G transgenic chickens produced by crossing 3D8 scFv G transgenic rooster and wild type hens were screened by genomic PCR and immunohistochemistry analysis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00345288183164
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http://dx.doi.org/10.1016/j.rvsc.2019.01.025DOI Listing
January 2019
5 Reads

Investigation of Safety Profile of Four Species and of Kaurenoic Acid by /Microsome Test.

Evid Based Complement Alternat Med 2019 10;2019:7631531. Epub 2019 Jan 10.

Laboratory of Research in Applied Microbiology (LAPEMA), University of Franca, Avenida Dr. Armando Salles de Oliveira 201, 14404-600 Franca, SP, Brazil.

Trees of the genus are native to the tropical regions of Latin America and Western Africa. sp is widely used as a popular medicine and it has various ethnopharmacological indications, including gonorrhea, bronchitis, asthma, skin ulcers, ulcers, sore throat, uterine infections, general inflammations, cancer, and leishmanioses. Kaurenoic acid is a naturally occurring diterpene found in and has been used as an anti-inflammatory, treatment of ulcer, leishmaniasis, and cancer. Read More

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http://dx.doi.org/10.1155/2019/7631531DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348810PMC
January 2019
1 Read

Health-related quality of life varies in different respiratory disorders: a multi-case control population based study.

BMC Pulm Med 2019 Feb 7;19(1):32. Epub 2019 Feb 7.

Unit of Epidemiology and Medical Statistics, Department of Diagnostics and Public Health, University of Verona, c/o Istituti Biologici II, Strada Le Grazie 8, 37134, Verona, Italy.

Background And Objective: Health-related quality of life (HRQL) in respiratory diseases has been generally investigated in clinical settings, focusing on a single disorder. In this study on a general population sample, we assessed the relationship between HRQL and several respiratory diseases studied simultaneously (COPD, current (CA) and past (PA) asthma, allergic (AR) and non-allergic (NAR) rhinitis and chronic bronchitis (CB).

Methods: Controls (n = 328) and cases of NAR (n = 95), AR (n = 163), CB (n = 48), CA (n = 224), PA (n = 126) and COPD (n = 28) were recruited in the centre of Verona in the frame of the Italian multi-case control GEIRD (Gene Environment Interactions in Respiratory Diseases) study; HRQL was measured through the SF-36 questionnaire. Read More

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http://dx.doi.org/10.1186/s12890-019-0796-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367788PMC
February 2019
1 Read

Srolo Bzhtang, a traditional Tibetan medicine formula, inhibits cigarette smoke induced airway inflammation and muc5ac hypersecretion via suppressing IL-13/STAT6 signaling pathway in rats.

J Ethnopharmacol 2019 Feb 4. Epub 2019 Feb 4.

Research Center for High Altitude Medicine, Qinghai University, Xining 810001, China; Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province, Xining 810001, China. Electronic address:

Ethnopharmacological Relevance: Srolo Bzhtang (SBT), a traditional Tibetan medicine formula, was first documented in the ancient Tibetan medical work Four Medical Tantras (rGyud-bzhi) in the eighth century AD. It has been widely used to treat lung "phlegm-heat" syndromes such as chronic bronchitis and chronic obstructive pulmonary disease (COPD).

Objective: The aim of this study was to evaluate the potential influences of SBT on airway inflammation and mucus secretion and to reveal the underlying mechanism in a rat model of cigarette smoke (CS)-induced chronic bronchitis (CB). Read More

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http://dx.doi.org/10.1016/j.jep.2019.02.006DOI Listing
February 2019
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Spontaneous Rectus Sheath Hematoma: An Uncommon Cause of Acute Abdominal Pain.

Am J Case Rep 2019 Feb 7;20:163-166. Epub 2019 Feb 7.

Department of Internal Medicine, United Health Services Hospitals, Wilson Medical Center, Johnson City, NY, USA.

BACKGROUND A clinical condition that is often misdiagnosed, rectus sheath hematoma (RSH) is usually seen in the context of blunt abdominal trauma and/or anticoagulation therapy, rarely occurring spontaneously. We present a case of spontaneous rectus sheath hematoma (SRSH) without obvious risk factors and review the literature regarding diagnosis modalities and management. The aim of this case presentation is to highlight this rare clinical condition and emphasize the role of the physical exam in determining the appropriate treatment approach. Read More

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http://dx.doi.org/10.12659/AJCR.913246DOI Listing
February 2019
1 Read

Hydrogen sulfide donor NaHS causes bronchitis with enhanced respiratory secretion in rats.

J Toxicol Sci 2019 ;44(2):107-112

Department of Forensic Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University.

Inhalation of toxic gases is dangerous to humans; experiments using toxic gases themselves are also hazardous to researchers. Gas-releasing molecules are widely used as alternatives to toxic gases, but their impacts on the whole body remain to be examined. To investigate responses during hydrogen sulfide (HS) poisoning, rats (Sprague-Dawley, male, 8-week-old) were intraperitoneally (i. Read More

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http://dx.doi.org/10.2131/jts.44.107DOI Listing
January 2019
1 Read

Prospective observational study in patients with obstructive lung disease: NOVELTY design.

ERJ Open Res 2019 Feb 1;5(1). Epub 2019 Feb 1.

School of Biological Sciences, University of Manchester, Manchester, UK.

Asthma and chronic obstructive pulmonary disease (COPD) have overlapping clinical features and share pathobiological mechanisms but are often considered distinct disorders. Prospective, observational studies across asthma, COPD and asthma-COPD overlap are limited. NOVELTY is a global, prospective observational 3-year study enrolling ∼12 000 patients ≥12 years of age from primary and specialist clinical practices in 19 countries (ClinicalTrials. Read More

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http://dx.doi.org/10.1183/23120541.00036-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355976PMC
February 2019
2 Reads

Idiopathic chronic productive cough and response to open-label macrolide therapy: An observational study.

Respirology 2019 Feb 5. Epub 2019 Feb 5.

The Asthma Centre, Nottingham NIHR Biomedical Research Centre, University of Nottingham, Nottingham City Hospital, Nottingham, UK.

Background And Objective: Adult patients with chronic productive cough of unknown cause are commonly seen in respiratory clinics. We have previously described a subgroup of these patients who have a short-lived response to standard antibiotic treatment but a prolonged response to 3 months of low-dose azithromycin therapy.

Methods: This observational study describes the physiological, radiological and pathological features of this patient cohort along with their response to a 12-week open-label trial of 250 mg azithromycin thrice weekly. Read More

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http://dx.doi.org/10.1111/resp.13483DOI Listing
February 2019
1 Read

Effect of Pullet Vaccination on Development and Longevity of Immunity.

Viruses 2019 Feb 2;11(2). Epub 2019 Feb 2.

Poultry Diagnostic and Research Center, Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.

Avian respiratory disease causes significant economic losses in commercial poultry. Because of the need to protect long-lived poultry against respiratory tract pathogens from an early age, vaccination programs for pullets typically involve serial administration of a variety of vaccines, including infectious bronchitis virus (IBV), Newcastle disease virus (NDV), and infectious laryngotracheitis virus (ILTV). Often the interval between vaccinations is only a matter of weeks, yet it is unknown whether the development of immunity and protection against challenge when vaccines are given in short succession occurs in these birds, something known as viral interference. Read More

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http://www.mdpi.com/1999-4915/11/2/135
Publisher Site
http://dx.doi.org/10.3390/v11020135DOI Listing
February 2019
8 Reads

Near-Complete Genome Sequence of Infectious Bronchitis Virus Strain VFAR-047 (GI-16 Lineage), Isolated in Peru.

Microbiol Resour Announc 2019 Jan 31;8(5). Epub 2019 Jan 31.

Laboratorios de Investigación y Desarrollo, FARVET, Chincha Alta, Ica, Peru.

Here, we report the near-complete genome sequence of the infectious bronchitis virus (IBV) strain VFAR-047, isolated in Peru in 2014. This strain was classified into GI lineage 16 (GI-16) based on both the genome and Spike 1 (S1) sequence analysis. Furthermore, four potential recombination events with other GI-16 and GI-11 strains were identified. Read More

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http://dx.doi.org/10.1128/MRA.01555-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357641PMC
January 2019
1 Read

Mucus Hydration in Subjects with Stable Chronic Bronchitis: A Comparison of Spontaneous and Induced Sputum.

COPD 2019 Feb 4:1-9. Epub 2019 Feb 4.

c Marsico Lung Institute/Cystic Fibrosis Research Center, University of North Carolina at Chapel Hill , Chapel Hill , North Carolina , USA.

Mucus hydration is important in mucus clearance and lung health. This study sought to test the relative utility of spontaneous sputum (SS) versus the reasonably noninvasive induced sputum (IS) samples for measurement of mucus hydration. SS and IS samples were collected over a 2-day study interval. Read More

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http://dx.doi.org/10.1080/15412555.2019.1566892DOI Listing
February 2019
1 Read

Overdiagnosis of COPD in subjects with unobstructed spirometry - a BOLD analysis.

Chest 2019 Jan 31. Epub 2019 Jan 31.

Respiratory Epidemiology and Public Health, Imperial College, London, United Kingdom.

Background: There are several reports on underdiagnosis of COPD, while little is known about COPD overdiagnosis and overtreatment. We describe the overdiagnosis and the prevalence of spirometrically defined false positive COPD, as well as their relationship with overtreatment across 23 population samples in 20 countries participating in the BOLD Study between 2003-2012.

Methods: A false positive diagnosis of COPD was considered when participants reported a doctor's diagnosis of COPD, but post-bronchodilator spirometry was unobstructed (FEV/FVC>LLN). Read More

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http://dx.doi.org/10.1016/j.chest.2019.01.015DOI Listing
January 2019
1 Read

Pelargonium sidoides radix extract EPs 7630 reduces rhinovirus infection through modulation of viral binding proteins on human bronchial epithelial cells.

PLoS One 2019 1;14(2):e0210702. Epub 2019 Feb 1.

Pulmonary Cell Research & Pneumology, Department Biomedicine & Department of Internal Medicine, University & University Hospital Basel, Basel, Switzerland.

Bronchial epithelial cells are the first target cell for rhinovirus infection. The course of viral infections in patients with acute bronchitis, asthma and COPD can be improved by oral application of Pelargonium sidoides radix extract; however, the mechanism is not well understood. This study investigated the in vitro effect of Pelargonium sidoides radix extract (EPs 7630) on the expression of virus binding cell membrane and host defence supporting proteins on primary human bronchial epithelial cells (hBEC). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210702PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358071PMC
February 2019
1 Read

Current views on metabolic syndrome.

Vnitr Lek 2019 ;64(12):1156-1159

The theory of metabolic syndrome originated 30 years ago. Several definitions try to explain the frequent common incidence of the risk factors for atherosclerosis. At first the syndrome of insulin resistance was involved. Read More

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January 2019
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[Acute Respiratory Tract Infections/Acute Bronchitis].

Dtsch Med Wochenschr 2019 Feb 31;144(3):185-188. Epub 2019 Jan 31.

Klinik für Pneumologie, Universitätsmedizin Essen - Ruhrlandklinik, Westdeutsches Lungenzentrum am Universitätsklinikum Essen.

Respiratory tract infections and acute bronchitis are one of the major indications for which antibiotics are prescribed. As most of respiratory tract infections are caused by viruses and antibiotic therapy is rarely indicated. Reasons for the unnecessary prescription of antibiotics in this patient population are false expectations regarding the course and duration of common cold symptoms and especially coughing. Read More

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http://dx.doi.org/10.1055/a-0655-8058DOI Listing
February 2019
1 Read

Neutrophil elastase inhibitory effects of pentacyclic triterpenoids from Eriobotrya japonica (loquat leaves).

J Ethnopharmacol 2019 Jan 28. Epub 2019 Jan 28.

School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:

Ethnopharmacological Relevance: Eriobotrya japonica, a traditional herbal medicine in China and Japan, has long been used to treat chronic bronchitis and coughs.

Aim Of The Study: Pentacyclic triterpenoids (PTs), especially ursolic acid (UA), have been found as reversibly and competitively human neutrophil elastase (HNE) inhibitors. However, the limited solubility and poor bioavailability of PTs hinder their clinical use. Read More

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http://dx.doi.org/10.1016/j.jep.2019.01.037DOI Listing
January 2019
1 Read

THE EFFECT OF VIBRO-ACOUSTIC STIMULATION ON CELL DYNAMICS OF INFLAMMATION IN RATS AND THE POSSIBILITIES FOR VIBROACOUSTIC SOUND THERAPY IN COMPLEX TREATMENT OF BRONCHITIS IN CHILDREN.

Georgian Med News 2018 Dec(285):107-111

Kharkiv Medical Academy of Postgraduate Education; Kharkiv National Medical University, Ukraine.

One of the methods of physiotherapy used in the complex treatment of various diseases is vibroacoustic exposure (VAE), however, the anti-inflammatory effect of this factor has not been studied insufficiently. The purpose of this research was to study the effect of VAE on the cellular dynamics of the inflammation focus. The experimental study was performed on 72 male Wistar rats weighing 180-200 g. Read More

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December 2018
1 Read

Occupational exposures and incidence of chronic bronchitis and related symptoms over two decades: the European Community Respiratory Health Survey.

Occup Environ Med 2019 Jan 30. Epub 2019 Jan 30.

Barcelona Institute of Global Health (ISGlobal), Barcelona, Spain.

Objectives: Chronic bronchitis (CB) is an important chronic obstructive pulmonary disease (COPD)-related phenotype, with distinct clinical features and prognostic implications. Occupational exposures have been previously associated with increased risk of CB but few studies have examined this association prospectively using objective exposure assessment. We examined the effect of occupational exposures on CB incidence in the European Community Respiratory Health Survey. Read More

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http://dx.doi.org/10.1136/oemed-2018-105274DOI Listing
January 2019
1 Read

Effect of experimental Ornithobacterium rhinotracheale infection along with live infectious bronchitis vaccination in broiler chickens.

Poult Sci 2019 Jan;98(1):105-111

Department of Animal Production, College of Food and Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia.

Ornithobacterium rhinotracheale (ORT), a bacterium causing respiratory tract infection, has led to a significant problem in the intensive poultry production in Egypt. Polymerase chain reaction-amplified 784-bp specific ORT DNA fragments were found in 7 ORT isolates from lungs, air sacs, and tracheas of commercial broilers or layers in Egypt in 2015. The objective of this study was to investigate the role of the live variant IBV 4/91 with ORT infection. Read More

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http://dx.doi.org/10.3382/ps/pey324DOI Listing
January 2019
1 Read

Among All Miners, Coal Miners Demonstrate A Disproportionately High Prevalence of Obstructive Spirometric Abnormality and Chronic Bronchitis.

J Occup Environ Med 2019 Jan 17. Epub 2019 Jan 17.

University of New Mexico School of Medicine, Albuquerque, NM, USA (AS, XS, OM, NA, LSC); and Miners' Col Raton, NM, USA (AS, CP).

Objective: To compare the prevalence of chronic obstructive pulmonary disease (COPD) between miners extracting coal versus other minerals.

Methods: The study population was based on New Mexico miners, mostly Hispanic and American Indian, attending a rural community-based mobile screening clinic program between 1989 and 2014. We compared self-reported symptoms, lung diseases, and spirometric patterns between 1,353 coal miners and 4,140 non-coal miners. Read More

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http://dx.doi.org/10.1097/JOM.0000000000001547DOI Listing
January 2019
1 Read

Maternal levels of perfluoroalkyl substances (PFASs) during pregnancy and childhood allergy and asthma related outcomes and infections in the Norwegian Mother and Child (MoBa) cohort.

Environ Int 2019 Mar 23;124:462-472. Epub 2019 Jan 23.

Norwegian Institute of Public Health, Division of Infection Control and Environmental Health, Oslo, Norway. Electronic address:

Introduction: Prenatal exposure to perfluoroalkyl substances (PFASs) has been inconsistently associated with asthma and allergic diseases and increased number of infections in early childhood. We examined the association of PFASs measured in pregnancy with childhood asthma, allergies and common infectious diseases in a prospective pregnancy cohort followed to age 7 years.

Material And Methods: Six PFASs (out of 19 measured) with at least 80% of measurements above the limit of quantification (LOQ) in maternal plasma during pregnancy in two subcohorts of the Norwegian Mother and Child Cohort Study (MoBa) were analyzed in relation to health outcomes: perfluorooctane sulfonic acid (PFOS), acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), perfluoroundecanoic acid (PFUnDA), and perfluoroheptane sulfonic acid (PFHpS). Read More

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http://dx.doi.org/10.1016/j.envint.2018.12.041DOI Listing
March 2019
1 Read

Systemic markers of inflammation in smokers with symptoms despite preserved spirometry in SPIROMICS.

Chest 2019 Jan 23. Epub 2019 Jan 23.

University of California, San Francisco - San Francisco (USA).

Background: Chronic respiratory symptoms and exacerbation-like events are common among ever smokers without airflow limitation on spirometry. The pathobiology of respiratory disease in this subgroup remains poorly defined, but may be due to underlying inflammation that overlaps with COPD or asthma. We hypothesized that symptoms, exacerbations, and functional measures of disease severity among smokers with preserved spirometry would be associated with markers of systemic inflammation, similar to what is reported in bone fide COPD, rather than elevated type 2 inflammation which is often present in asthma. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00123692193003
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http://dx.doi.org/10.1016/j.chest.2018.12.022DOI Listing
January 2019
2 Reads

The relationship between ventilator-associated pneumonia and chronic obstructive pulmonary disease: what is the current evidence?

Eur J Clin Microbiol Infect Dis 2019 Jan 24. Epub 2019 Jan 24.

Vall d'Hebron Institute of Research (VHIR) & CIBERES, Instituto Salud Carlos III, Barcelona, Spain.

Chronic obstructive pulmonary disease (COPD) affects approximately 65 million people from which > 25% will require intensive care unit (ICU) admission. Ventilator-associated pneumonia (VAP) is the commonest ICU infection and results in increased morbidity/mortality and costs. The literature on the interaction between COPD and VAP is scarce and controversial. Read More

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http://dx.doi.org/10.1007/s10096-019-03486-2DOI Listing
January 2019
2 Reads

Factors associated with exacerbations among adults with asthma according to electronic health record data.

Asthma Res Pract 2019 18;5. Epub 2019 Jan 18.

1Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA.

Background: Asthma is a chronic inflammatory lung disease that affects 18.7 million U.S. Read More

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http://dx.doi.org/10.1186/s40733-019-0048-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339400PMC
January 2019
3 Reads

New onset erythematous nodules in an elderly woman.

Dermatol Online J 2018 Aug 15;24(8). Epub 2018 Aug 15.

Harvard Medical School, Boston, Massachusetts.

An 86-year- old woman with a history of recurrent bronchitis and giant cell arteritis presented for new onset, cyclic and migratory erythematous nodules associated with fatigue and weight loss. Although a systemic vasculitis was initially suspected, elevated inflammatory markers and symptoms persisted despite aggressive corticosteroid therapy. Excisional biopsy of one nodule showed dense suppurative and granulomatous inflammation that was rife with acid-fast bacilli. Read More

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August 2018
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Mucoactive Agents in the Therapy of Upper Respiratory Airways Infections: Fair to Describe Them Just as Mucoactive?

Clin Med Insights Ear Nose Throat 2019 9;12:1179550618821930. Epub 2019 Jan 9.

Pole Pharma Consulting, Breganzona, Switzerland.

Background: Upper and lower respiratory tract infections are common conditions for which medical advice is sought, and their management relies on the use of prescription and over-the-counter (OTC) medicines. Ambroxol, bromhexine, carbocysteine, erdosteine, -acetyl cysteine (NAC), and sobrerol are mucoactive agents for which clinical trials have been conducted, have been awarded well-established status by regulatory authorities, and are available as OTC or prescription products.

Objective: To briefly review the evidence-based efficacy and safety of these substances in the therapy of upper respiratory airways infections. Read More

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http://dx.doi.org/10.1177/1179550618821930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328955PMC
January 2019
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Prescriptive adherence to GINA guidelines and asthma control: An Italian cross sectional study in general practice.

Respir Med 2019 Jan 16;146:10-17. Epub 2018 Nov 16.

Pulmonary Environmental Epidemiology Unit, CNR Institute of Clinical Physiology, Via Trieste no. 41, 56126, Pisa, Italy; CNR Institute of Biomedicine and Molecular Immunology "A. Monroy", Via U. La Malfa no. 153, 90146, Palermo, Italy.

Background: Although general practitioners (GPs) are frequently the first healthcare professionals whom asthma patients refer to for their symptoms, few studies have explored the extent of adherence to guidelines for asthma management based on data provided directly by GPs. Aims of the present study were to assess drug prescriptions for asthma by GPs and to evaluate prescriptive adherence to GINA guidelines (GL) and its relationship with disease control in real life.

Methods: 995 asthmatic patients (45% males, mean age 43. Read More

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http://dx.doi.org/10.1016/j.rmed.2018.11.001DOI Listing
January 2019
4 Reads

Lycopene mitigates pulmonary emphysema induced by cigarette smoke in a murine model.

J Nutr Biochem 2018 Dec 21;65:93-100. Epub 2018 Dec 21.

Department of Biological Sciences, Laboratory of Experimental Pathophysiology, Federal University of Ouro Preto, Minas Gerais, Brazil. Electronic address:

Chronic obstructive pulmonary disease (COPD) is an inflammatory lung disease characterized by a non-fully reversible airflow limitation comprising chronic bronchitis and pulmonary emphysema both being induced by cigarette smoke (CS) exposure. Lycopene has shown antioxidant and anti-inflammatory properties that can prevent acute lung inflammation and emphysema. We hypothesized that administration with lycopene would repair lung damage in emphysema caused by CS exposure. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09552863183015
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http://dx.doi.org/10.1016/j.jnutbio.2018.12.008DOI Listing
December 2018
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Multiple Respiratory Microbiota Profiles Are Associated With Lower Airway Inflammation in Children With Protracted Bacterial Bronchitis.

Chest 2019 Jan 17. Epub 2019 Jan 17.

Child Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Australia; Department of Respiratory and Sleep Medicine, Queensland Children's Hospital and the Centre for Children's Health Research, Queensland University of Technology, Brisbane, Australia.

Background: Effective management of protracted bacterial bronchitis (PBB) is needed to prevent chronic disease (eg, bronchiectasis). Understanding the contributions of ongoing airway infection and inflammation is important to achieving optimal PBB treatments. The aim of this study was to compare BAL microbiota, bacterial biomass, and inflammatory markers in children with PBB and age-matched control patients. Read More

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http://dx.doi.org/10.1016/j.chest.2019.01.002DOI Listing
January 2019
3 Reads

Rhinoviruses and Their Receptors.

Chest 2019 Jan 17. Epub 2019 Jan 17.

Department of Pediatrics, University of Wisconsin-Madison, Madison, WI.

Human rhinoviruses (RVs) are picornaviruses that can cause a variety of upper and lower respiratory tract illnesses, including the common cold, bronchitis, pneumonia, and exacerbations of chronic respiratory diseases such as asthma. There are currently > 160 known types of RVs classified into three species (A, B, and C) that use three different cellular membrane glycoproteins expressed in the respiratory epithelium to enter the host cell. These viral receptors are intercellular adhesion molecule 1 (used by the majority of RV-A and all RV-B types), low-density lipoprotein receptor family members (used by 12 RV-A types), and cadherin-related family member 3 (CDHR3; used by RV-C). Read More

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http://dx.doi.org/10.1016/j.chest.2018.12.012DOI Listing
January 2019
8 Reads

Research Progress of Glycyrrhizic Acid on Antiviral Activity.

Mini Rev Med Chem 2019 Jan 18. Epub 2019 Jan 18.

State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, No.163 Xianlin Road, Nanjing 210023. China.

Glycyrrhizic acid (GA), a triterpene isolated from the roots and rhizomes of licorice, named Glycyrrhiza glabra, is the principal bioactive ingredient of anti-viral, anti-inflammatory and hepatoprotective effects. GA has been used in the clinical treatment of hepatitis, bronchitis, gastric ulcer, AIDS (acquired immunodeficiency syndrome), certain cancers and skin diseases. It has a direct effect on anti-HBV (hepatitis B virus) via affecting the HBsAg (hepatitis B surface antigen) to extracellular secretion, improving liver dysfunction in patients with chronic hepatitis B, and ultimately improving the immune status of HBV. Read More

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http://dx.doi.org/10.2174/1389557519666190119111125DOI Listing
January 2019
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The role of MMP-12 gene polymorphism - 82 A-to-G (rs2276109) in immunopathology of COPD in polish patients: a case control study.

BMC Med Genet 2019 Jan 18;20(1):19. Epub 2019 Jan 18.

Second Department of Internal Medicine of Collegium Medicum, Jagiellonian University in Cracow, Skawińska street 8, 31-066, Kraków, Poland.

Background: Major symptoms of chronic obstructive pulmonary disease (COPD) are chronic bronchitis and emphysema leading from lung tissue destruction, that is an effect of an imbalance between metalloproteinases (MMPs) and their tissue inhibitors activity. As potential factor involved in this COPD pathogenesis, MMP-12 is considered. We investigated the role of genetic polymorphism and protein level of MMP-12 in the COPD development among Poles. Read More

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http://dx.doi.org/10.1186/s12881-019-0751-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339316PMC
January 2019
2 Reads

Household incense burning and children's respiratory health: A cohort study in Hong Kong.

Pediatr Pulmonol 2019 Jan 16. Epub 2019 Jan 16.

Jockey Club School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong SAR, China.

Background: Incense burning is an important source of indoor air pollution in many Asian regions. We investigated the associations between household incense burning and lung function, lung function growth and respiratory diseases and symptoms in primary school children in Hong Kong.

Methods: A total of 4041 children (mean age: 9. Read More

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http://dx.doi.org/10.1002/ppul.24251DOI Listing
January 2019
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Procalcitonin to guide antibiotic decision making.

Curr Opin Infect Dis 2019 Jan 14. Epub 2019 Jan 14.

Department of Internal Medicine, Kantonsspital Aarau, Aarau.

Purpose Of Review: There is convincing evidence linking antibiotic-stewardship efforts which include the infection marker procalcitonin (PCT) to more rational use of antibiotics with improvements in side-effects and clinical outcomes. This is particularly true in the setting of respiratory infection and sepsis. Yet, some recent trials have shown no benefit of PCT-guided care. Read More

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http://dx.doi.org/10.1097/QCO.0000000000000522DOI Listing
January 2019
19 Reads

Catechin rich butanol fraction extracted from Acacia catechu L. (a thirst quencher) exhibits immunostimulatory potential.

J Food Drug Anal 2019 Jan 2;27(1):195-207. Epub 2018 Jul 2.

School of Biosciences, Mahatma Gandhi University, Priyadarshini Hills, Kottayam, 686560, Kerala, India. Electronic address:

Acacia catechu L., (Fabaceae) named as "catechu" is a plant, the decoction of heartwood of which is daily consumed as thirst quencher by a good percentage of the population in South India. The plant is mainly distributed in India and other Asian countries. Read More

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http://dx.doi.org/10.1016/j.jfda.2018.06.010DOI Listing
January 2019
4 Reads

Outpatient Antibiotic Prescribing for Acute Respiratory Infections During Influenza Seasons.

JAMA Netw Open 2018 Jun 1;1(2):e180243. Epub 2018 Jun 1.

Centers for Disease Control and Prevention, Atlanta, Georgia.

Importance: Acute respiratory infections (ARIs) are the syndrome for which antibiotics are most commonly prescribed; viruses for which antibiotics are ineffective cause most ARIs.

Objectives: To characterize antibiotic prescribing among outpatients with ARI during influenza season and to identify targets for reducing inappropriate antibiotic prescribing for common ARI diagnoses, including among outpatients with laboratory-confirmed influenza.

Design, Setting, And Participants: Cohort study enrolling outpatients aged 6 months or older with ARI evaluated at outpatient clinics associated with 5 US Influenza Vaccine Effectiveness Network sites during the 2013-2014 and 2014-2015 influenza seasons. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2018.0243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6324415PMC
June 2018
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Impact of Matrix Metalloproteinase 9 on COPD Development in Polish Patients: Genetic Polymorphism, Protein Level, and Their Relationship with Lung Function.

Biomed Res Int 2018 10;2018:6417415. Epub 2018 Dec 10.

Institute of Physiotherapy, Faculty of Physical Education and Physiotherapy, Opole University of Technology, Opole, Poland.

Chronic obstructive pulmonary disease (COPD) is characterized by a decline of lung function and symptoms such as chronic bronchitis and emphysema leading from lung tissue destruction. Increased activity of matrix metalloproteinases (MMPs) and an imbalance between MMPs and their tissue inhibitors (TIMPs) are considered as factors influencing the pathogenesis of COPD. We investigated the role of genetic polymorphism and expression level of MMP-9 and concentration of its complexes with TIMPs in the development of COPD among Polish patients. Read More

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http://dx.doi.org/10.1155/2018/6417415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311264PMC
December 2018
2 Reads