39,382 results match your criteria Bronchitis


Genetic effects of welding fumes on the development of respiratory system diseases.

Comput Biol Med 2019 Apr 8;108:142-149. Epub 2019 Apr 8.

Bone Biology Division, Garvan Institute of Medical Research, Darlinghurst, NSW, Australia; Discipline of Pathology, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Australia. Electronic address:

Background: The welding process releases potentially hazardous gases and fumes, mainly composed of metallic oxides, fluorides and silicates. Long term welding fume (WF) inhalation is a recognized health issue that carries a risk of developing chronic health problems, particularly respiratory system diseases (RSDs). Aside from general airway irritation, WF exposure may drive direct cellular responses in the respiratory system which increase risk of RSD, but these are not well understood. Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.04.004DOI Listing

Effects of the routine multiple vaccinations on the expression of innate immune molecules and induction of histone modification in ovarian cells of layer chicks.

Poult Sci 2019 Apr 19. Epub 2019 Apr 19.

Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima 739-8528, Japan.

The aim of this study was to determine whether vaccination affects the expression of Toll-like receptors (TLRs), cytokines, and avian β-defensins (AvBDs) in the chick ovary with or without lipopolysaccharide (LPS) stimulation. White Leghorn female chicks were administered vaccines for infectious bronchitis, Marek's disease, Newcastle disease, and infectious bursal disease during the first 14 D after hatching and ovarian tissues were collected on day 21. Control chicks received water or dilution buffer in place of vaccine. Read More

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https://academic.oup.com/ps/advance-article/doi/10.3382/ps/p
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http://dx.doi.org/10.3382/ps/pez214DOI Listing
April 2019
7 Reads

Efficacy and safety of namilumab, a human monoclonal antibody against granulocyte-macrophage colony-stimulating factor (GM-CSF) ligand in patients with rheumatoid arthritis (RA) with either an inadequate response to background methotrexate therapy or an inadequate response or intolerance to an anti-TNF (tumour necrosis factor) biologic therapy: a randomized, controlled trial.

Arthritis Res Ther 2019 Apr 18;21(1):101. Epub 2019 Apr 18.

Takeda Development Centre, London, UK.

Background: Namilumab (AMG203), an immunoglobulin G1 monoclonal antibody that binds with high affinity to granulocyte-macrophage colony-stimulating factor (GM-CSF), was evaluated in a phase II randomized, double-blind, placebo-controlled study to investigate the efficacy and safety in patients with rheumatoid arthritis (RA) with an inadequate response to methotrexate (MTX-IR) or anti-tumour necrosis factor therapy (TNF-IR).

Methods: Subcutaneous namilumab (20, 80, or 150 mg) or placebo was administered at baseline and weeks 2, 6, and 10 in patients on stable background methotrexate therapy who were with MTX-IR or TNF-IR. Primary endpoint was mean change from baseline in the 28-joint Disease Activity Score, C-reactive protein version (DAS28-CRP) at week 12 comparing each of the three doses of namilumab to placebo. Read More

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http://dx.doi.org/10.1186/s13075-019-1879-xDOI Listing

Validation of a Clinical Instrument for Measuring the Severity of Acute Bronchitis in Children - The BSS-ped.

Open Respir Med J 2018 19;12:81-82. Epub 2018 Dec 19.

Clinic for Paediatrics, Evangelic Hospital Hamm, Hamm, Germany.

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http://dx.doi.org/10.2174/1874306401812010081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425065PMC
December 2018
1 Read

Fine particulate matter (PM) enhances airway hyperresponsiveness (AHR) by inducing necroptosis in BALB/c mice.

Environ Toxicol Pharmacol 2019 Mar 12;68:155-163. Epub 2019 Mar 12.

Department of Respiratory and Critical Care Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, 050000, China. Electronic address:

Objective: To observe the effects of prolonged exposure to high concentrations of PM on the trachea and lungs of mice and to determine whether the damages to the trachea and lung are induced by necroptosis.

Methods: Six- to eight-week-old female Balb/C mice of PM group were restrained in an animal restraining device using a nose-only "PM online enrichment system" for 8 weeks, in Shijiazhuang, Hebei, China. Anti -Fas group was exposed to PM inhalation and anti-Fas treatment via intranasal instillation. Read More

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http://dx.doi.org/10.1016/j.etap.2019.03.013DOI Listing
March 2019
1 Read

Plastic bronchitis: Three cases caused by influenza B virus Yamagata lineage.

Pediatr Int 2019 Apr 14. Epub 2019 Apr 14.

Department of Emergency and Critical Care Medicine, Seirei Hamamatsu General Hospital, Hamamatsu City, Shizuoka, Japan.

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ped.13799
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http://dx.doi.org/10.1111/ped.13799DOI Listing
April 2019
2 Reads

Perspectives in veterinary medicine: Description and classification of bronchiolar disorders in cats.

J Vet Intern Med 2019 Apr 13. Epub 2019 Apr 13.

Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan.

This Perspectives in Veterinary Medicine article seeks to define, describe putative causes, and discuss key diagnostic tests for primary and secondary bronchiolar disorders to propose a classification scheme in cats with support from a literature review and case examples. The small airways (bronchioles with inner diameters <2 mm), located at the transitional zone between larger conducting airways and the pulmonary acinus, have been overlooked as major contributors to clinical syndromes of respiratory disease in cats. Because the trigger for many bronchiolar disorders is environmental and humans live in a shared environment with similar susceptibility, understanding these diseases in pet cats has relevance to One Health. Read More

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http://dx.doi.org/10.1111/jvim.15473DOI Listing
April 2019
1 Read

Comparative safety of abatacept in rheumatoid arthritis with COPD: A real-world population-based observational study.

Semin Arthritis Rheum 2019 Mar 16. Epub 2019 Mar 16.

Centre for Clinical Epidemiology, Lady Davis Institute - Jewish General Hospital, 3755 Cote Ste-Catherine, H-461, Montreal, Québec H3T 1E2, Canada; Division of Respiratory Medicine, Jewish General Hospital, Montreal, Québec, Canada.

Objective: The ASSURE randomized trial of abatacept safety in rheumatoid arthritis (RA) reported more frequent respiratory adverse events with abatacept among the subgroup of 54 patients with chronic obstructive pulmonary disease (COPD), leading to a label warning. We assessed the risk of adverse respiratory events associated with abatacept, compared with other biologic DMARDs (bDMARDs), among patients with RA and COPD in a real-world observational setting.

Methods: We formed a prevalent new-user cohort of patients with RA and COPD treated with bDMARDs within the US-based MarketScan databases from 2007 to 2014. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00490172193002
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http://dx.doi.org/10.1016/j.semarthrit.2019.03.007DOI Listing
March 2019
2 Reads

Indoor cannabis smoke and children's health.

Prev Med Rep 2019 Jun 16;14:100853. Epub 2019 Mar 16.

Center for Behavioral Epidemiology and Community Health (C-BEACH), Graduate School of Public Health, San Diego State University, San Diego, CA, USA.

Cannabis use is increasing and cannabis is typically consumed by smoking. This study explored how indoor secondhand cannabis smoke (SCS) was associated with child health. As part of a larger trial, air particle monitors were placed in 298 homes of families with at least one cigarette smoker and one child under 14 years old in San Diego County, California. Read More

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http://dx.doi.org/10.1016/j.pmedr.2019.100853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441784PMC
June 2019
4 Reads

Evaluation of uncomplicated acute respiratory tract infection management in veterans: A national utilization review.

Infect Control Hosp Epidemiol 2019 Apr;40(4):438-446

Center for Medication Safety (VAMedSAFE),Hines Veterans Affairs Medical Center,Chicago, Illinois.

Background: Antibiotics are overprescribed for acute respiratory tract infections (ARIs). Guidelines provide criteria to determine which patients should receive antibiotics. We assessed congruence between documentation of ARI diagnostic and treatment practices with guideline recommendations, treatment appropriateness, and outcomes. Read More

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http://dx.doi.org/10.1017/ice.2019.16DOI Listing
April 2019
1 Read

A two-year prospective study of small poultry flocks in Ontario, Canada, part 1: prevalence of viral and bacterial pathogens.

J Vet Diagn Invest 2019 Apr 11:1040638719843577. Epub 2019 Apr 11.

Departments of Pathobiology (Brochu, Lillie, Susta).

In Ontario, within the past few years, there has been a marked increase in the number of non-commercial poultry flocks (referred to as "small flocks"). Small poultry flocks may act as a reservoir of avian and zoonotic pathogens, given the flocks' limited access to veterinary services, inadequate biosecurity practices, and increased risk of contact with wild birds. Despite these potential risks, there is a scarcity of data concerning the prevalence of poultry and zoonotic pathogens among these flocks. Read More

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http://dx.doi.org/10.1177/1040638719843577DOI Listing
April 2019
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Infections and pathology of free-roaming backyard chickens on St. Kitts, West Indies.

J Vet Diagn Invest 2019 Apr 11:1040638719843638. Epub 2019 Apr 11.

Departments of Biomedical Sciences (Bolfa, Callanan, Ketzis, Marchi, Cheng, Huynh, Lavinder, Boey).

Free-roaming chickens on Caribbean islands are important sentinels for local avian diseases and those introduced by birds migrating through the Americas. We studied 81 apparently healthy unvaccinated free-roaming chickens from 9 parishes on St. Kitts, an eastern Caribbean island. Read More

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http://journals.sagepub.com/doi/10.1177/1040638719843638
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http://dx.doi.org/10.1177/1040638719843638DOI Listing
April 2019
2 Reads

Surveillance for Avibacterium paragallinarum in autopsy cases of birds from small chicken flocks using a real-time PCR assay.

J Vet Diagn Invest 2019 Apr 11:1040638719844297. Epub 2019 Apr 11.

California Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, University of California-Davis, Davis, CA.

Infectious coryza is a severe respiratory disease of chickens associated with large economic losses in affected commercial flocks. The fastidious causative pathogen, Avibacterium paragallinarum, is difficult to recover and identify, resulting in delayed diagnosis and enhanced spread of the agent. Small poultry flocks are increasingly common in rural and suburban environments. Read More

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http://dx.doi.org/10.1177/1040638719844297DOI Listing
April 2019
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A two-year prospective study of small poultry flocks in Ontario, Canada, part 2: causes of morbidity and mortality.

J Vet Diagn Invest 2019 Apr 11:1040638719843575. Epub 2019 Apr 11.

Departments of Pathobiology (Brochu, Lillie, Susta).

Non-commercial poultry flocks (referred to as "small flocks") have become increasingly popular in Canada. Despite this popularity, little is known about the main causes of morbidity and mortality (health status) in these flocks. We assessed the baseline prevalence of infectious and non-infectious diseases among Ontario's small poultry flocks by conducting a prospective surveillance study over a 2-y period. Read More

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http://dx.doi.org/10.1177/1040638719843575DOI Listing
April 2019
2 Reads

Adenovirus type 5 community-acquired pneumonia in an immunocompetent patient.

BMJ Case Rep 2019 Apr 8;12(4). Epub 2019 Apr 8.

Department of Microbiology, Tokyo Medical University, Tokyo, Japan.

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http://dx.doi.org/10.1136/bcr-2018-228914DOI Listing
April 2019
1 Read

Mucociliary Clearance in Former Tobacco Smokers with Both Chronic Obstructive Pulmonary Disease and Chronic Bronchitis and the Effect of Roflumilast.

J Aerosol Med Pulm Drug Deliv 2019 Apr 8. Epub 2019 Apr 8.

1 Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: Little is known of the repeatability and reliability of mucociliary clearance (MCC) in former tobacco smokers who have both chronic obstructive pulmonary disease (COPD) and chronic bronchitis (CB). Less is known of the effect of roflumilast, a selective inhibitor of PDE4, on MCC in these patients.

Methods: Former tobacco smokers with COPD and CB were treated for 4 weeks with either roflumilast, or placebo, in a randomized, crossover trial. Read More

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http://dx.doi.org/10.1089/jamp.2018.1459DOI Listing
April 2019
1 Read

HL301 in the treatment of acute bronchitis: a phase 2b, randomized, double-blind, placebocontrolled, multicenter study.

Korean J Intern Med 2019 Apr 9. Epub 2019 Apr 9.

Department of Internal Medicine, Chung-Ang University College of Medicine, Seoul, Korea.

Background/aims: There is insufficient quality data to recommend the use of herbs for the treatment of acute bronchitis. Small number of randomized trials of plant extracts for this purpose were determined to be low quality and there are concerns for the safety. HL301 is a combined product of seven medicinal plants. Read More

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http://kjim.org/journal/view.php?doi=10.3904/kjim.2018.181
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http://dx.doi.org/10.3904/kjim.2018.181DOI Listing
April 2019
2 Reads

Identifying Alpha-1 Antitrypsin Deficiency Based on Computed Tomography Evidence of Emphysema.

Cureus 2019 Jan 28;11(1):e3971. Epub 2019 Jan 28.

Internal Medicine, Jersey Shore University Medical Center, Neptune City, USA.

Introduction Chronic obstructive pulmonary disease (COPD) is most commonly caused by smoking tobacco or cigarettes. However, alpha-1 antitrypsin deficiency (AATD) is the only genetic disorder known to cause COPD and these patients often present with emphysema earlier in life and with more severe disease. Additionally, AATD patients are often misdiagnosed with other lung disorders, and the diagnosis is often delayed for up to a decade. Read More

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https://www.cureus.com/articles/17149-identifying-alpha-1-an
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http://dx.doi.org/10.7759/cureus.3971DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438683PMC
January 2019
2 Reads

Riociguat for treatment of pulmonary hypertension in COPD - a translational study.

Eur Respir J 2019 Apr 7. Epub 2019 Apr 7.

Excellence Cluster Cardiopulmonary System, University of Giessen and Marburg Lung Center (UGMLC), member of the German Center for Lung Research (DZL), Justus-Liebig-University, Giessen, Germany

Chronic obstructive pulmonary disease (COPD) which comprises the phenotypes of chronic bronchitis and emphysema is often associated with pulmonary hypertension (PH). However, currently no approved therapy exists for PH-COPD. Signalling of the nitric oxide/cyclic guanoside monophosphate (NO-cGMP) axis plays an important role in PH and COPD. Read More

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http://dx.doi.org/10.1183/13993003.02445-2018DOI Listing
April 2019
4 Reads

Chronic Obstructive Pulmonary Disease: Evaluation and Management.

Med Clin North Am 2019 May 14;103(3):453-461. Epub 2019 Mar 14.

Department of Thoracic Medicine and Surgery, Lewis Katz School of Medicine at Temple University, 3401 North Broad Street, 7th Floor Parkinson Pavilion, Philadelphia, PA 19140, USA.

Chronic obstructive pulmonary disease (COPD) is a leading cause of death nationally and worldwide. Cigarette smoking is the most common risk factor in the development of COPD. Disease course is variable with some patients having a high degree of obstruction and minimal symptoms, whereas others with better lung function have a greater symptoms burden. Read More

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http://dx.doi.org/10.1016/j.mcna.2018.12.005DOI Listing
May 2019
2 Reads

Perspectives on Wnt signal pathway in the pathogenesis and therapeutics in chronic obstructive pulmonary disease.

J Pharmacol Exp Ther 2019 Apr 5. Epub 2019 Apr 5.

Brown University

Chronic obstructive pulmonary disease (COPD) is a chronic lung disease with progressive airflow limitation and lung function decline. The pathogenic mechanisms for this disease include oxidative stress, inflammatory responses, disturbed protease/anti-protease equilibrium, apoptosis/proliferation imbalance, senescence, autophagy, metabolic reprogramming, and mitochondrial dysfunction. Wnt signaling pathway is an evolutionarily conserved signaling pathway, which is abnormal in COPD, including chronic bronchitis and pulmonary emphysema. Read More

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http://dx.doi.org/10.1124/jpet.118.256222DOI Listing
April 2019
1 Read

Antibiotic prescription among outpatients in a prefecture of Japan, 2012-2013: a retrospective claims database study.

BMJ Open 2019 Apr 3;9(4):e026251. Epub 2019 Apr 3.

Division of General Internal Medicine, Jichi Medical University Hospital, Shimotsuke, Tochigi, Japan.

Objectives: To investigate oral antibiotic prescribing patterns and identify factors associated with antibiotic prescriptions, with the aim of guiding future interventions to reduce inappropriate prescribing.

Design: Retrospective cohort study.

Setting: Database of public health insurance claims in Kumamoto prefecture (Japan). Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026251DOI Listing
April 2019
2 Reads

Morphology and Function of the Lymphatic Vasculature in Patients With a Fontan Circulation.

Circ Cardiovasc Imaging 2019 Apr;12(4):e008074

Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Denmark (S.M., N.T., B.K., V.H.).

Background: The Fontan procedure has revolutionized the treatment of univentricular hearts. However, it is associated with severe complications such as protein-losing enteropathy, plastic bronchitis, and peripheral edema that may involve the lymphatic circulation. We aimed to assess lymphatic function and morphology in patients with a univentricular circulation. Read More

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http://dx.doi.org/10.1161/CIRCIMAGING.118.008074DOI Listing
April 2019
2 Reads

Bronchiolitis Hospitalization in Southern Brazil from 2002 to 2012: A Count Time-series Approach.

Rev Soc Bras Med Trop 2019 Mar 28;52:e20180329. Epub 2019 Mar 28.

Programa de Pós-Graduação em Bioestatística, Departamento de Estatística, Universidade Estadual de Maringá, Maringá, PR, Brasil.

Introduction: Because the antibody neutralizing respiratory syncytial virus (anti-RSV) has a short period of immunization and high cost, the identification of regions and months of highest occurrence of bronchiolitis is very important.

Methods: An Autoregressive Conditional Poisson model was constructed for count data and compared to the standard time-series Poisson regression model.

Results: The metropolitan area of Paraná presented the highest average occurrence from May to July. Read More

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http://dx.doi.org/10.1590/0037-8682-0329-2018DOI Listing
March 2019
3 Reads

Quality of Community Pharmacy Practice in Antibiotic Self-Medication Encounters: A Simulated Patient Study in Upper Egypt.

Antibiotics (Basel) 2019 Apr 1;8(2). Epub 2019 Apr 1.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.

Antibiotic misuse, either by patients or healthcare professionals, is one of the major contributing factors to antimicrobial resistance. In many Middle Eastern countries including Egypt, there are no strict regulations regarding antibiotic dispensing by community pharmacies. In this study, we examined antibiotic dispensing patterns in Egyptian community pharmacies. Read More

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http://dx.doi.org/10.3390/antibiotics8020035DOI Listing
April 2019
3 Reads

MRI Evaluation of Lymphatic Abnormalities in the Neck and Thorax after Fontan Surgery: Relationship with Outcome.

Radiology 2019 Apr 2:180877. Epub 2019 Apr 2.

From the Department of Radiology (D.M.B., D.S.) and Division of Cardiology (A.G.D., E.M.P., R.E.M., J.A.J., H.G., M.L.O., M.A.F., M.A.H., S.L.P., K.K.W., D.J.G., J.R., A.C.G., M.J.G., J.J.R., Y.D.), Children's Hospital of Philadelphia, 34th and Civic Center Blvd, Philadelphia, PA 19104; and University of Pennsylvania School of Medicine, Philadelphia, PA (D.M.B., A.G.D., H.G., M.L.O., M.A.F., M.A.H., S.L.P., K.K.W., D.S., D.J.G., J.R., A.C.G., M.J.G., J.J.R., Y.D.).

Background The Fontan operation is performed for surgical palliation of single ventricle physiology. This operation is usually preceded by a superior cavopulmonary connection (SCPC); lymphatic abnormalities after SCPC may be demonstrated at MRI and prior to the Fontan operation. Purpose To determine if the degree of neck and thoracic lymphatic abnormalities at T2-weighted MRI in patients after superior cavopulmonary connection (SCPC) correlated with surgical outcomes from the Fontan procedure. Read More

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http://dx.doi.org/10.1148/radiol.2019180877DOI Listing
April 2019
3 Reads

Purulent bronchitis in 1917 and pandemic influenza in 1918.

Lancet Infect Dis 2019 Apr 27;19(4):360-361. Epub 2019 Mar 27.

Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, USA.

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http://dx.doi.org/10.1016/S1473-3099(19)30114-8DOI Listing
April 2019
2 Reads

Baloxavir: A Novel Single-Dose Oral Antiviral for the Treatment of Influenza.

Sr Care Pharm 2019 Apr;34(4):243-252

To review the pharmacology, pharmacokinetics, pharmacodynamics, clinical efficacy, tolerability, dosing, and administration of baloxavir marboxil (BXM), as well as its place in the treatment of influenza.
A search of PubMed and Google Scholar using the terms "baloxavir" and "S-033188" was performed. The manufacturer's website was also reviewed to further identify relevant information. Read More

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http://dx.doi.org/10.4140/TCP.n.2019.243.DOI Listing
April 2019
1 Read

Indian Consensus on Diagnosis of Cough at Primary Care Setting.

J Assoc Physicians India 2019 Jan;67(1):92-98

Consultant Chest Physician, Rakshit Hospital, Chennai, Tamil Nadu.

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January 2019
3 Reads

Respiratory Morbidity of Roadside Shopkeepers Exposed to Traffic-related Air Pollution in Bhopal, India.

J Health Pollut 2019 Mar 7;9(21):190305. Epub 2019 Mar 7.

Department of Epidemiology, National Institute for Research in Environmental Health, Kamla Nehru Hospital Building, Gandhi Medical College Campus, Bhopal, India.

Background: Traffic-related air pollution (TRAP) is a major source of ambient air pollution in urban areas. Shopkeepers of heavily trafficked roadside shops are persistently exposed to high levels of TRAP.

Objectives: To estimate the prevalence of respiratory morbidity in shopkeepers of shops in heavily trafficked roadside areas in Bhopal city (India) and to determine any association with long term exposure to TRAP. Read More

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http://dx.doi.org/10.5696/2156-9614-9.21.190305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421956PMC
March 2019
4 Reads

[From acute cough to chronic cough in adults: Overview on a common reason for consultation].

Presse Med 2019 Mar 26. Epub 2019 Mar 26.

CHU de Toulouse, hôpital Larrey, service de pneumologie, pôle des voies respiratoires, 31059 Toulouse, France.

Cough is divided into two categories: acute cough lasting less than 3 weeks, and chronic cough lasting more than 8 weeks. Acute cough is usually triggered by a viral infection of the upper airways. Evidence of treatment effectiveness is low and management of acute cough is complex in clinical practice. Read More

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http://dx.doi.org/10.1016/j.lpm.2019.02.009DOI Listing
March 2019
2 Reads

Understanding the importance of key risk factors in predicting chronic bronchitic symptoms using a machine learning approach.

BMC Med Res Methodol 2019 Mar 29;19(1):70. Epub 2019 Mar 29.

Department of Preventive Medicine, University of Southern California, 2001 N. Soto Street, MC-9234, Los Angeles, CA, 90089, USA.

Background: Chronic respiratory symptoms involving bronchitis, cough and phlegm in children are underappreciated but pose a significant public health burden. Efforts for prevention and management could be supported by an understanding of the relative importance of determinants, including environmental exposures. Thus, we aim to develop a prediction model for bronchitic symptoms. Read More

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http://dx.doi.org/10.1186/s12874-019-0708-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441159PMC
March 2019
3 Reads

New lignans, sesquiterpenes and other constituents from twigs and leaves of Rhododendron micranthum.

Fitoterapia 2019 Mar 25;135:15-21. Epub 2019 Mar 25.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, People's Republic of China. Electronic address:

Rhododendron micranthum is used traditionally as a remedy for the treatment of chronic bronchitis in China. To clarify the chemical basis and provide a reference for the rational use of this medicinal plant, a phytochemical study was carried out on the twigs and leaves of R. micranthum, which afforded eight new compounds (1-8) and eight known compounds (9-16). Read More

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http://dx.doi.org/10.1016/j.fitote.2019.03.025DOI Listing
March 2019
1 Read
2.216 Impact Factor

Change in inhaled corticosteroid treatment and COPD exacerbations: an analysis of real-world data from the KOLD/KOCOSS cohorts.

Respir Res 2019 Mar 28;20(1):62. Epub 2019 Mar 28.

Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Background: This cohort study of patients with chronic obstructive pulmonary disease (COPD) was performed to evaluate the status of inhaled corticosteroid (ICS) prescriptions following the 2017 revision of the Global Initiative for Chronic Obstructive Lung Disease guidelines.

Methods: A total of 1144 patients from the Korean Obstructive Lung Disease and Korea Chronic Obstructive Pulmonary Disorders Subgroup Study cohorts, with final follow-up visits completed between 2017 and 2018, were analyzed. Features indicative of ICS usage were as follows: a history of asthma, blood eosinophils of ≥300 cells/μl, or ≥ 2 exacerbations in the year prior to enrollment. Read More

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http://dx.doi.org/10.1186/s12931-019-1029-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437901PMC
March 2019
1 Read

Clostridium difficile-associated diarrhea following the therapy with antibiotic and proton pump inhibitors in a 77-year-old man with several comorbidities: A case report.

Medicine (Baltimore) 2019 Mar;98(13):e15004

Department of Pharmacy.

Rationale: Clostridium difficile-associated diarrhea (CDAD) remains a persistent challenge, with substantially increased incidence and severity. The rising burden of CDAD requires urgent identification of preventable risk factors.

Patients Concerns: A 77-year-old man with the symptoms of abdominal pain and watery diarrhea was readmitted to the hospital, who received cephalosporins and proton pump inhibitors (PPIs) during the initial hospitalization for 12 days until discharge. Read More

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http://dx.doi.org/10.1097/MD.0000000000015004DOI Listing
March 2019
1 Read

Use of delayed antibiotic prescription in primary care: a cross-sectional study.

BMC Fam Pract 2019 Mar 26;20(1):45. Epub 2019 Mar 26.

Iberoamerican Cochrane Center, Biomedical Research Institute Sant Pau (IIB Sant Pau), Barcelona, Spain.

Background: One of several strategies developed to reduce inappropriate antibiotic use in situations where the indication is not clear is delayed antibiotic prescription (DAP), defined as an antibiotic prescription issued for the patient to take only in case of feeling worse or not feeling better several days after the visit. We conducted a survey to identify DAP use in Spanish primary care settings.

Methods: We surveyed 23 healthcare centers located in 4 autonomous regions where a randomized controlled trial (RCT) on DAP was underway. Read More

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http://dx.doi.org/10.1186/s12875-019-0934-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434640PMC
March 2019
1 Read

The Effects of Liver Transplantation in Children with Niemann-Pick Disease Type B.

Liver Transpl 2019 Mar 26. Epub 2019 Mar 26.

Department of Liver Surgery, Ren Ji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, P. R. China.

We evaluated the effects of liver transplantation in children with Niemann-Pick disease (NPD) type B. From October 2006 to October 2018, 7 of 1512 children that received liver transplantation at Ren Ji Hospital were diagnosed as NPD type B. The median age at diagnosis is 12-month (6-14 months) with initial presentations of hepatosplenomegaly, growth retardation, repeated pneumonia and diarrhea. Read More

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http://dx.doi.org/10.1002/lt.25457DOI Listing
March 2019
2 Reads

Bronchoalveolar lavage fluid lymphocytosis in 104 dogs (2006-2016).

J Vet Intern Med 2019 Mar 26. Epub 2019 Mar 26.

Department of Pathology, Microbiology and Immunology, University of California School of Veterinary Medicine, Davis, California.

Background: Bronchoalveolar lavage (BAL) fluid cytology and culture are used to characterize respiratory diseases in dogs. Little is known about disorders associated with increased numbers of lymphocytes in BAL fluid.

Objective: To evaluate duration of clinical signs and detection of specific respiratory diagnoses in dogs with BAL lymphocytosis. Read More

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http://dx.doi.org/10.1111/jvim.15489DOI Listing
March 2019
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Genetic Advances in COPD: Insights from COPDGene.

Am J Respir Crit Care Med 2019 Mar 25. Epub 2019 Mar 25.

Brigham and Women's Hospital, Channing Division of Network Medicine, Boston, Massachusetts, United States.

Chronic obstructive pulmonary disease (COPD) is a common and progressive disease that is influenced by both genetic and environmental factors. For many years, knowledge of the genetic basis of COPD was limited to Mendelian syndromes, such as alpha-1 antitrypsin deficiency and cutis laxa, caused by rare genetic variants. Fortunately, over the past decade, the proliferation of genome-wide association studies (GWAS), the accessibility of whole genome sequencing, and the development of novel methods for analyzing genetic variation data have led to a substantial increase in our understanding of genetic variants that play a role in COPD susceptibility and COPD-related phenotypes. Read More

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http://dx.doi.org/10.1164/rccm.201808-1455SODOI Listing
March 2019
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Idiopathic Hypereosinophilic Syndrome in an Elderly Female: A Case Report.

Am J Case Rep 2019 Mar 23;20:381-384. Epub 2019 Mar 23.

Department of Pulmonary, Critical Care and Sleep Medicine, University of Colorado, Denver, CO, USA.

BACKGROUND Hypereosinophilic syndrome (HES) is defined as hypereosinophilia with eosinophil mediated organ damage or dysfunction, provided that other causes of organ damage have been excluded. CASE REPORT An 83-year-old female presented with worsening dyspnea for 3 weeks. She was initially diagnosed with bronchitis and prescribed oral antibiotics along with prednisone taper. Read More

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http://dx.doi.org/10.12659/AJCR.912747DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441311PMC
March 2019
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Glycosylation of the viral attachment protein of avian coronavirus is essential for host cell and receptor binding.

J Biol Chem 2019 Mar 22. Epub 2019 Mar 22.

Utrecht University, Netherlands.

Avian coronaviruses, including infectious bronchitis virus (IBV), are important respiratory pathogens of poultry. The heavily glycosylated IBV spike protein is responsible for binding to host tissues. Glycosylation sites in the spike protein are highly conserved across viral genotypes, suggesting an important role for this modification in the virus life cycle. Read More

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http://dx.doi.org/10.1074/jbc.RA119.007532DOI Listing
March 2019
2 Reads

Identifying Predictors of Pressurized Submarine Escape Training (PSET) Attrition.

Mil Med 2019 Mar;184(Supplement_1):476-487

Naval Submarine Medical Research Laboratory, Trout Avenue, Naval Submarine Base New London, Groton, CT.

Pressurized Submarine Escape Training (PSET) physically prepares submariners to safely escape a submarine at depth. Failure to complete PSET is not a submarine service disqualification. Serious medical incidents are rare, but the safety record tradeoff has been low throughput. Read More

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http://dx.doi.org/10.1093/milmed/usy377DOI Listing
March 2019
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Tracheoscopic Findings and Their Impact on Respiratory Symptoms in Children with Esophageal Atresia.

Eur J Pediatr Surg 2019 Mar 21. Epub 2019 Mar 21.

Division of Pediatric Surgery, Universitat zu Koln Medizinische Fakultat, Koln, Nordrhein-Westfalen, Germany.

Introduction:  Esophageal atresia (EA) is often accompanied by tracheobronchial malformations leading to stridor, recurrent bronchitis, and occasionally to life-threatening obstructive apnea after surgical repair. The aim of this study was to identify the presence of tracheomalacia in patients with EA and tracheoesophageal fistula (TEF) pre- and postoperatively and to find endoscopic correlates leading to clinical airway symptoms.

Methods:  In a cohort of 362 patients with EA-TEF who underwent 595 tracheoscopies at the Children's Hospital of Cologne between January 1983 and December 2002, impaired tracheal lumen, localization of TEF, tracheal pulsations, and corresponding clinical symptoms were retrospectively analyzed. Read More

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http://dx.doi.org/10.1055/s-0039-1683871DOI Listing
March 2019
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Fuzzy logic and hospital admission due to respiratory diseases using estimated values by mathematical model.

Cien Saude Colet 2019 Mar;24(3):1083-1090

Departamento de Energia, Faculdade de Engenharia de Guaratinguetá (FEG), UNESP. Av. Ariberto Pereira da Cunha 333, Pedregulho. 12516-410 Guaratinguetá SP Brasil.

Hospitalizations due to respiratory diseases generate financial costs for the Health System in addition to social costs. Objective of this study was to develop and validate a fuzzy linguistic model for prediction of hospitalization due to respiratory diseases. We constructed a fuzzy model for prediction of hospitalizations due to pneumonia, bronchitis, bronchiolitis and asthma second exposure to fine particulate matter (PM2. Read More

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http://dx.doi.org/10.1590/1413-81232018243.08172017DOI Listing
March 2019
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Rates of Chronic Medical Conditions in 1991 Gulf War Veterans Compared to the General Population.

Int J Environ Res Public Health 2019 Mar 16;16(6). Epub 2019 Mar 16.

Department of Environmental Health, Boston University School of Public Health, Boston, MA 02118, USA.

Prevalence of nine chronic medical conditions in the population-based Ft. Devens Cohort (FDC) of GW veterans were compared with the population-based 2013⁻2014 National Health and Nutrition Examination Survey (NHANES) cohort. Excess prevalence was calculated as the difference in prevalence estimates from the Ft. Read More

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http://dx.doi.org/10.3390/ijerph16060949DOI Listing
March 2019
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Applications of CRISPR systems in respiratory health: Entering a new 'red pen' era in genome editing.

Respirology 2019 Mar 18. Epub 2019 Mar 18.

Faculty of Science, School of Human Sciences and School of Agriculture and Environment, The University of Western Australia, Perth, WA, Australia.

Respiratory diseases, such as influenza infection, acute tracheal bronchitis, pneumonia, tuberculosis, chronic obstructive pulmonary disease, asthma, lung cancer and nasopharyngeal carcinoma, continue to significantly impact human health. Diseases of the lung and respiratory tract are influenced by environmental conditions and socio-economic factors; however, many of these serious respiratory disorders are also rooted in genetic or epigenetic causes. Clustered regularly interspaced palindromic repeats (CRISPR) and CRISPR-associated (Cas) proteins, isolated from the immune system of prokaryotes, provide a tool to manipulate gene sequences and gene expression with significant implications for respiratory research. Read More

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http://dx.doi.org/10.1111/resp.13527DOI Listing
March 2019
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Clinical phenotypes of COPD and health-related quality of life: a cross-sectional study.

Int J Chron Obstruct Pulmon Dis 2019;14:565-573. Epub 2019 Mar 1.

Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia,

Introduction: The Spanish COPD guideline (GesEPOC) classifies COPD into four clinical phenotypes based on the exacerbation frequency and dominant clinical manifestations. In this study, we compared the disease-specific health-related quality of life (HRQoL) of patients with different clinical phenotypes.

Methods: This was a cross-sectional study of patients with COPD attending the respiratory medicine clinic of University of Malaya Medical Centre from 1 June 2017 to 31 May 2018. Read More

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https://www.dovepress.com/clinical-phenotypes-of-copd-and-he
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http://dx.doi.org/10.2147/COPD.S196109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402617PMC
March 2019
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Update on the clinical development of gefapixant, a P2X3 receptor antagonist for the treatment of refractory chronic cough.

Pulm Pharmacol Ther 2019 Mar 14. Epub 2019 Mar 14.

Merck & Co., Inc., 2000 Galloping Hill Road, Kenilworth, NJ, 07033, USA. Electronic address:

Chronic cough, or cough lasting >8 weeks, is often associated with underlying medical conditions (ie, asthma, gastroesophageal reflux disease, nonasthmatic eosinophilic bronchitis, and upper-airway cough syndrome). In some patients with chronic cough, treatment of these underlying conditions does not resolve the cough (refractory chronic cough [RCC]), or none of these conditions are present (unexplained chronic cough [UCC]). Despite appropriate medical evaluation, patients with RCC or UCC frequently experience cough persisting for many years, as there are currently no targeted pharmacological approaches approved for the treatment of these conditions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10945539183026
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http://dx.doi.org/10.1016/j.pupt.2019.03.006DOI Listing
March 2019
3 Reads