Search Our Scientific Publications & Authors

Lung Cancer 2020 Apr 30;145:132-139. Epub 2020 Apr 30.

Department of Imaging, Dana Farber Cancer Institute, 450 Brookline Ave, Boston, MA, 02215, USA; Department of Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

Objective: Investigate the spectrum of radiographic patterns of radiation pneumonitis (RP) in lung cancer patients and identify imaging markers for high-grade RP and RP-related death.

Methods: Eighty-two patients with lung cancer treated with conventional chest radiotherapy who had symptomatic RP were identified from the radiation oncology database. The imaging features of RP were studied for association with high-grade RP (Grade ≥3) and RP-related death (Grade 5). Read More

Arch Acad Emerg Med 2020 18;8(1):e55. Epub 2020 Apr 18.

Department of Radiology, Shohada-E-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: Computed tomography (CT) imaging has quickly found its place as a beneficial tool in the detection of coronavirus disease 2019 (COVID-19). To date, only a few studies have reported the distribution of lung lesions by segment. This study aimed to evaluate the lobar and segmental distribution of COVID-19 pneumonia based on patients' chest CT scan. Read More

Clin Imaging 2020 May 15. Epub 2020 May 15.

GE Healthcare, Hangzhou 310000, China.

Purpose: To analyze clinical and thin-section computed tomographic (CT) data from the patients with coronavirus disease (COVID-19) to predict the development of pulmonary fibrosis after hospital discharge.

Materials And Methods: Fifty-nine patients (31 males, 28 females; mean age: 41 years, range: 25 to 70 years) with confirmed COVID-19 infection performed follow-up thin-section CT of the thorax. After 31. Read More

J Thorac Dis 2020 Apr;12(4):1588-1594

Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, China.

Kartagener syndrome (KS) is an autosomal recessive disorder characterized by situs inversus, paranasal sinusitis and bronchiectasis. We report the successful use of double lung transplant (DLTx) to treat end-stage KS. A 49-year-old Han woman was admitted to Renmin Hospital (Wuhan University, China) in September 2017 with a ≥15 year history of chronic productive cough that had worsened during the past year. Read More

Eur J Radiol 2020 Apr 23;128:108988. Epub 2020 Apr 23.

The Perlelman School of Medicine at the University of Pennsylvania, Department of Radiology, Silverstein 1, 3400 Spruce St., Philadelphia, PA, 19104, USA. Electronic address:

Purpose: Human metapneumovirus has been increasingly identified as a cause of lower respiratory tract infection in adults worldwide. The CT imaging features of human metapneumovirus in adults have not been characterized. The purpose of this paper is to determine the imaging features of human metapneumovirus and to compare them with features of other viruses. Read More

Indian J Pediatr 2020 May 8. Epub 2020 May 8.

Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, 110029, India.

Primary immunodeficiency disorders (PIDD) are a group of disorders presenting with recurrent infections. The authors retrospectively reviewed the imaging records of 24 proven cases of PIDD and correlated the imaging findings with the type of defect. Final diagnoses were categorized in four groups; Group I (humoral immunodeficiency), Group 2 (cell mediated immunodeficiency), Group 3 (phagocytic disorders) and Group 4 (others). Read More

Eur Radiol 2020 May 4. Epub 2020 May 4.

Department of Radiology, Nanjing First Hospital, Nanjing Medical University, No.68, Changle Road, Nanjing, 210006, China.

Objectives: To characterize and interpret the CT imaging signs of the 2019 novel coronavirus (COVID-19) pneumonia in China.

Materials And Methods: The CT images of 130 patients diagnosed as COVID-19 pneumonia from several hospitals in China were collected and their imaging features were analyzed and interpreted in detail.

Results: Among the 130 patients, we can see (1) distribution: 14 cases with unilateral lung disease and 116 cases with bilateral disease, the distribution was mainly lobular core (99 cases) and subpleural (102 cases); (2) number: 9 cases with single lesion, 113 cases with multiple lesions, and 8 cases with diffuse distribution; (3) density: 70 cases of pure ground glass opacity (GGO), and 60 cases of GGO with consolidation; (4) accompanying signs: vascular thickening (100 cases), "parallel pleura sign" (98 cases), "paving stone sign" (100 cases), "halo sign" (18 cases), "reversed halo sign" (6 cases), pleural effusion (2 cases), and pneumonocele (2 cases). Read More

Cureus 2020 Mar 30;12(3):e7474. Epub 2020 Mar 30.

Internal Medicine, Cooper University Hospital, Camden, USA.

Inflammatory bowel disease (IBD) is an umbrella term encompassing intestinal conditions Crohn's disease and ulcerative colitis (UC), characterized by inflammation of intestinal wall, differing in location, depth, pathophysiology, and sequela. Extraintestinal manifestations (EIM) of IBD commonly affect the skin, joints, eyes, and in rare instances, the lungs. Pulmonary involvement affects the large and small airways, serosal surface, and vasculature leading to a range of pathology, including bronchiectasis, pleural effusions, and necrobiotic nodules. Read More

Thorax 2020 Apr 28. Epub 2020 Apr 28.

Interstitial Lung Disease Unit, Department of Respiratory Medicine, Royal Brompton and Harefield NHS Foundation Trust, London, UK.

Aims: Patients with idiopathic pulmonary fibrosis (IPF) receiving antifibrotic medication and patients with non-IPF fibrosing lung disease often demonstrate rates of annualised forced vital capacity (FVC) decline within the range of measurement variation (5.0%-9.9%). Read More

Transpl Infect Dis 2020 Apr 23:e13285. Epub 2020 Apr 23.

Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Objective: To compare the chest CT patterns of acute graft-versus-host disease (aGVHD) and infections within 100 days after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in pediatric recipients to help hematologist make definitive diagnosis as early as possible.

Methods: A total of 143 pediatric recipients from January 2015 to June 2019 who were diagnosed pulmonary aGVHD or infections within 100 days after allo-HSCT were enrolled in this study. Two observers evaluated the extent and distribution (unilateral, bilateral) of the CT patterns. Read More

Can Assoc Radiol J 2020 Apr 20:846537120918834. Epub 2020 Apr 20.

Department of Radiology, Dezhou People's Hospital, Dezhou, Shandong, China.

Purpose: To explore the clinical and dynamic computed tomography features of coronavirus disease 2019.

Methods: We enrolled 24 patients with coronavirus disease 2019 treated at a regional center in Dezhou, China, from January 22 to February 5, 2020, and analyzed data retrospectively.

Results: Nineteen cases had close contact with people with coronavirus disease 2019, and five patients denied a travel history in Wuhan City or contact with patients having coronavirus disease 2019. Read More

Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 2020 Feb;38(2):140-144

Occupational Poisoning Department of Xuzhou Tumor Hospital. Xuzhou 221005, China.

To investigate the CT features of lung injury induced by paraquat poisoning and its relationship with prognosis, and to provide reference for the judgment of the condition and prognosis of paraquat poisoning. 146 cases of paraquat poisoning patients were treated in the Third People's Hospital of Xuzhou City from January 2013 to April 2016. The cases were divided into mild group, moderate-severe group and fulminant group according to the concentration of paraquat in urine. Read More

Zhonghua Yi Xue Za Zhi 2020 Apr;100(13):1007-1011

Department of Radiology, the Affiliated Infectious Diseases Hospital of Soochow University, the Fifth People's Hospital of Suzhou, Suzhou 215000, China.

To explore the CT imaging features of the 2019 novel coronavirus (2019-nCoV) infection in order to summarize the imaging characteristics of the disease and improve the ability of imaging diagnosis and early diagnosis of the disease. From January 13, 2020 to January 31, 2020, a total of 33 patients with 2019-nCoV infection diagnosed and treated by Suzhou Fifth People's Hospital were analyzed retrospectively, including 20 males and 13 females, with an average age of (50±12) years, ranging from 20 to 70 years old. There were 3 cases of mild type, 27 cases of common type and 3 cases of severe type. Read More

BMC Pediatr 2020 Apr 13;20(1):158. Epub 2020 Apr 13.

Department of Clinical Sciences and Community Health, University of Milan and Audiology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza, 35, Milan, Italy.

Background: Recurrent bacterial infections of the respiratory tract are one of the major clinical features of the primary ciliary dyskinesia (PCD), a rare genetic disease due to malfunctioning of motile cilia. Chronic infections and persistent inflammation of the respiratory system result in progressive lung disease. Aim of the study was to highlight the main factors associated with clinical, functional and anatomical deterioration in PCD patients. Read More

J Am Coll Radiol 2020 Mar 25. Epub 2020 Mar 25.

Department of Radiology, Tianjin Union Medical Center, Tianjin, China. Electronic address:

Purpose: To date, considerable knowledge gaps remain regarding the chest CT imaging features of Coronavirus Disease 2019 (COVID-19). We performed a systematic review and meta-analysis of results from published studies to date to provide a summary of evidence on detection of COVID-19 by chest CT and the expected CT imaging manifestations.

Methods: Studies were identified by searching PubMed database for articles published between December 2019 and February 2020. Read More

J Clin Med 2020 Apr 7;9(4). Epub 2020 Apr 7.

Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8523, Japan.

Background And Objective: Pre-existing interstitial lung disease (ILD) in lung cancer patients is considered a risk factor for anti-cancer drug-induced pneumonia; however, a method for evaluating ILD, including mild cases, has not yet been established. We aimed to elucidate whether the quantitative high-resolution computed tomography fibrosis score (HFS) is correlated with the risk of anti-cancer drug-induced pneumonia in lung cancer patients, even in those with mild pre-existing ILD.

Methods: The retrospective single-institute study cohort comprised 214 lung cancer patients who underwent chemotherapy between April 2013 and March 2016. Read More

Arch Iran Med 2020 04 1;23(4):272-276. Epub 2020 Apr 1.

Department of Respiratory Medicine, Zhoupu Hospital affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, China. No. 1500 Zhouyuan Road, Pudong new District, Shanghai 201318, China.

Background: In December 2019, an outbreak of a novel coronavirus disease (COVID-19; previously known as 2019-nCoV) was reported in Wuhan, Hubei province, China, which has subsequently affected more than 200 countries worldwide including Europe, North America, Oceania, Africa and other places. The number of infected people is rapidly increasing, while the diagnostic method of COVID-19 is only by nucleic acid testing.

Objective: To explain the epidemiological characteristics, clinical features, imaging manifestations and to judge diagnostic value of COVID-19 by analyzing the clinical data of COVID-19 suspected and confirmed patients in a non-outbreak, Shanghai, China. Read More

Pediatr Pulmonol 2020 Apr 8. Epub 2020 Apr 8.

Department of Pediatrics, Section of Pulmonology and Sleep Medicine, The Breathing Institute, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado.

Introduction: Mucolipidosis type II (MLII) is a lysosomal storage disease causing systemic deposition of mucopolysaccharides. We describe imaging and bronchoscopy findings not previously reported in the literature in a child with MLII.

Case: A 9-year-old with MLII s/p hematopoietic stem-cell transplant (HSCT), bronchiectasis, and aspiration presented with recurrent respiratory illnesses. Read More

Respir Med 2020 May 27;166:105940. Epub 2020 Mar 27.

Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, University of Texas Medical Branch (UTMB), Galveston, TX, USA. Electronic address:

Bronchiectasis is a complex, chronic respiratory condition, characterized by frequent cough and exertional dyspnea due to a range of conditions that include inherited mucociliary defects, inhalational airway injury, immunodeficiency states and prior respiratory infections. For years, bronchiectasis was classified as either being caused by cystic fibrosis or non-cystic fibrosis. Non-cystic fibrosis bronchiectasis, once considered an orphan disease, is more prevalent worldwide in part due to greater availability of chest computed tomographic imaging. Read More

Am J Respir Crit Care Med 2020 Apr 3. Epub 2020 Apr 3.

Cincinnati Children's Hospital Medical Center, Pediatrics & Radiology, Cincinnati, Ohio, United States;

Case Rep Pulmonol 2020 27;2020:8903809. Epub 2020 Feb 27.

Department of Internal Medicine, SUNY Downstate Medical Center, USA.

Bronchiectasis is characterized by permanent destruction of the airways that presents with productive cough, as well as bronchial wall thickening and luminal dilatation on computed tomographic (CT) scan of the chest; it is associated with high mortality. Accumulating data suggests higher rates of bronchiectasis among the HIV-positive population. This case series involves 14 patients with bronchiectasis and HIV followed at two major urban institutions from 1999 to 2018. Read More

AJR Am J Roentgenol 2020 Mar 14:1-7. Epub 2020 Mar 14.

Department of Radiology, Keck School of Medicine, University of Southern California, 1500 San Pablo St, Los Angeles, CA 90033.

Available information on CT features of the 2019 novel coronavirus disease (COVID-19) is scattered in different publications, and a cohesive literature review has yet to be compiled. This article includes a systematic literature search of PubMed, Embase (Elsevier), Google Scholar, and the World Health Organization database. Known features of COVID-19 on initial CT include bilateral multilobar ground-glass opacification (GGO) with a peripheral or posterior distribution, mainly in the lower lobes and less frequently within the right middle lobe. Read More

Respirol Case Rep 2020 Apr 8;8(3):e00539. Epub 2020 Mar 8.

Department of Respiratory Medicine Shinjuku Tsurukame Clinic Shibuya Japan.

Gene expression profiles of patients with progressive sarcoidosis, most of whom had evidence of fibrosis on imaging, have been reported to be similar to those of patients with inflammatory hypersensitivity pneumonitis, while expression profiles in progressive sarcoidosis did not resemble those of idiopathic pulmonary fibrosis. However, it is not known whether specific parenchymal features discerned on computed tomography (CT) imaging can predict development of fibrosis in pulmonary fibrosis. We herein describe a rare case of pulmonary sarcoidosis with honeycomb lung-like structures developing as a result of concentration of traction bronchiectasis distally, predominantly in both lower lung fields, which developed through shrinkage of consolidations comprising a "central-peripheral band" detected in a woman in her 60s, with non-caseating epithelioid granuloma. Read More

Magn Reson Imaging 2020 Jun 29;69:16-21. Epub 2020 Feb 29.

Division of Thoracic Imaging and Intervention, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States of America. Electronic address:

Purpose: Computed tomography (CT) imaging is the standard to assess interstitial lung disease. Magnetic resonance (MR) is potentially advantageous due to superior tissue characterization and better assessment of blood flow dynamics. This study aimed to evaluate idiopathic pulmonary fibrosis (IPF) using prototype 4D Stack of Stars GRE (StarVIBE) MR and compare it to CT. Read More

AJR Am J Roentgenol 2020 05 3;214(5):1072-1077. Epub 2020 Mar 3.

Department of Radiology, The Second Xiangya Hospital, Central South University, No. 139 Middle Remin Rd, Changsha, Hunan, 410011, P.R. China.

The increasing number of cases of confirmed coronavirus disease (COVID-19) in China is striking. The purpose of this study was to investigate the relation between chest CT findings and the clinical conditions of COVID-19 pneumonia. Data on 101 cases of COVID-19 pneumonia were retrospectively collected from four institutions in Hunan, China. Read More

Thorax 2020 Mar 26;75(3):269-278. Epub 2020 Feb 26.

Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK.

Background: Post-tuberculosis lung damage (PTLD) is a recognised consequence of pulmonary TB (pTB). However, little is known about its prevalence, patterns and associated outcomes, especially in sub-Saharan Africa and HIV-positive adults.

Methods: Adult (≥15 years) survivors of a first episode of pTB in Blantyre, Malawi, completed the St George's Respiratory Questionnaire, 6-minute walk test, spirometry and high-resolution CT (HRCT) chest imaging at TB treatment completion. Read More

J Microbiol Immunol Infect 2020 Feb 13. Epub 2020 Feb 13.

Division of Pediatric Pulmonology, Department of Pediatrics, Chang Gung Memorial Hospital at Linkou, and Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background: Primary immunodeficiency (PID) accompanying with recurrent respiratory infections is thought to have a devastating effect on lung function. However, the associations between the airway structural abnormalities on chest computed tomography (CT), severity of dyspnea, and deterioration of pulmonary function test (PFT) have not been fully addressed.

Methods: Children diagnosed with PID in a tertiary referred center in northern Taiwan were enrolled. Read More

J Clin Immunol 2020 Apr 19;40(3):503-514. Epub 2020 Feb 19.

Translational Immunology Research Program, University of Helsinki, Helsinki, Finland.

Hypomorphic IL2RG mutations may lead to milder phenotypes than X-SCID, named variably as atypical X-SCID or X-CID. We report an 11-year-old boy with a novel c. 172C>T;p. Read More

Eur Radiol 2020 May 10;30(5):2722-2730. Epub 2020 Feb 10.

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Objectives: To investigate CT imaging features associated with poor clinical outcome after corticosteroid treatment in patients diagnosed with cryptogenic organizing pneumonia (COP) and connective tissue disease-related organizing pneumonia (CTD-OP) and to assess the difference in CT findings and treatment responses between COP and CTD-OP.

Methods: Chest CT images from 166 patients (COP, 131; CTD-OP, 35) with pathologically proven organizing pneumonia were reviewed by two thoracic radiologists. The type, distribution pattern, and extent of parenchymal abnormalities, along with other associated imaging features, were assessed for each patient. Read More

Rofo 2020 Feb 6. Epub 2020 Feb 6.

Radiology, Eberhard-Karls-University Tübingen, Tübingen, Germany.

Purpose:  In cystic fibrosis (CF) the phenotypic expression of complaints varies widely. Genotypes with sufficient pancreatic function (PS) exhibit milder lung disease compared to CF patients with insufficient pancreatic function (PI). The purpose of this study was to evaluate structural lung disease (SLD) in CF patients with differing pancreatic status but similar results on pulmonary function testing using a pulmonary magnetic resonance imaging score (MR-CF score). Read More

Eur Radiol 2020 May 5;30(5):2703-2711. Epub 2020 Feb 5.

Biomedical Imaging Group Rotterdam, Department of Radiology and Nuclear Medicine, Erasmus MC, room NA-2611, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.

Purpose: To estimate airway tapering in control subjects and to assess the usability of tapering as a bronchiectasis biomarker in paediatric populations.

Methods: Airway tapering values were semi-automatically quantified in 156 children with control CTs collected in the Normal Chest CT Study Group. Airway tapering as a biomarker for bronchiectasis was assessed on spirometer-guided inspiratory CTs from 12 patients with bronchiectasis and 12 age- and sex-matched controls. Read More

Curr Med Imaging Rev 2019;15(8):796-801

Pulmonary Diseases Department, VERSA Hospital, Nevsehir, Turkey.

Background: Mounier Kuhn Syndrome (MKS) is a rare congenital anomaly characterized by abnormal dilatation of the trachea and main bronchi. The aim of this study is to discuss tracheal volume measurement in MKS, and the pathologies accompanying MKS, especially pulmonary artery enlargement.

Materials And Methods: 38 patients, 18 of whom were diagnosed with MKS and 20 as control group, were included in the study. Read More

S D Med 2019 Nov;72(11):518-520

Division of Pulmonary, Critical Care, Sleep and Allergy, University of Nebraska Medical Center, Omaha, Nebraska.

Swyer-James-Macleod syndrome is a rare radiologic entity with radiolucent lung fields which could include the entire lung, a lobe or a subsegment. The pathogenesis is unclear but is thought to be related to childhood pulmonary viral and non-viral infections with subsequent vascular and alveolar distortion. It usually presents incidentally in asymptomatic patients on imaging, but could present with recurrent pulmonary infections, shortness of breath, cough, hemoptysis or bronchiectasis. Read More

ERJ Open Res 2019 Oct 2;5(4). Epub 2019 Dec 2.

Dept of Respiratory Medicine, Royal Adelaide Hospital, Adelaide, Australia.

The human T-cell leukaemia virus type 1 (HTLV-1) is associated with pulmonary inflammation. Indigenous Australians in central Australia have a very high prevalence of HTLV-1 infection and we hypothesised that this might contribute to high rates of bronchiectasis in this population. 80 Indigenous adults with confirmed bronchiectasis, each matched by age, sex and language to two controls without bronchiectasis, were recruited. Read More

Respir Res 2020 Jan 6;21(1). Epub 2020 Jan 6.

Department of Medical and Surgical Sciences & Neurosciences, University of Siena, Siena, Italy.

Background: Serum chitotriosidase is a promising biomarker that has shown high specificity and sensitivity in patients with sarcoidosis. The aim of this study was to investigate correlations between serum chitotriosidase, clinical phenotypes, disease localizations and different radiological lung involvement and to identify clinical features associated with over-expression of chitotriosidase in a large cohort of sarcoidosis patients.

Methods: Chitotriosidase activity was evaluated in a population of 694 consecutive patients (males 39%, age 55. Read More

Pediatr Rep 2019 Dec 2;11(4):8250. Epub 2019 Dec 2.

Department of Pediatrics, Divisions of Pediatric Cardiology and Pulmonology, University Hospital Liège.

We report the case of an 8-years-old girl with recurrent pulmonary infections and wheezing since infancy, in whom asthma and immunoglobulin-G deficiency were diagnosed at the age of 7 months. Since then, the patient was treated for asthma without any satisfactory control of the disease. Cardiomegaly was finally diagnosed radiologically that led to cardiac assessment. Read More

J Bras Pneumol 2020 20;46(2):e20190024. Epub 2019 Dec 20.

. Laboratório de Pesquisa em Imagens Médicas - LABIMED - Departamento de Radiologia, Pavilhão Pereira Filho, Irmandade Santa Casa de Misericórdia de Porto Alegre, Porto Alegre (RS) Brasil.

Objective: To determine the CT findings of multiple cavitary lung lesions that allow the differentiation between benign and malignant etiologies.

Methods: We reviewed CT scans, including patients with two or more cavitary lung lesions. We evaluated the number of cavitary lesions, their location, cavity wall thickness, and additional findings, correlating the variables with the diagnosis of a benign or malignant lesion. Read More

N Z Vet J 2020 Jul 29;68(4):231-237. Epub 2020 Jan 29.

The Animal Hospital at Murdoch University, Murdoch, WA, Australia.

A 2-year-old Rottweiler dog from Perth (WA, Australia) was referred for assessment of a chronic productive cough and weight loss. Severely enlarged bilateral superficial cervical lymph nodes and severely enlarged abdominal organs were present. The body condition score was poor and there was moderate muscle wasting. Read More

Pediatr Pulmonol 2020 02 17;55(2):407-417. Epub 2019 Dec 17.

Department of Paediatrics, University Malaya, Kuala Lumpur, Malaysia.

Introduction: Respiratory tract infections in children can result in respiratory sequelae. We aimed to determine the prevalence of, and factors associated with persistent respiratory sequelae 1 year after admission for a lower respiratory tract infection (LRTI).

Methodology: This prospective cohort study involved children 1 month to 5-years-old admitted with an LRTI. Read More

Zhonghua Jie He He Hu Xi Za Zhi 2019 Dec;42(12):901-906

Tuberculosis Diagnosis and Treatment Center, Shanghai Pulmonary Hospital, Tongji University, Shanghai Key Lab of Tuberculosis, Shanghai 200433, China.

To investigate the clinical characteristics and drug susceptibility test (DST) of patients infected with different nontuberculous mycobacteria (NTM). The patients with nontuberculous mycobacterial lung disease (NMLD) in Shanghai Pulmonary Hospital from March 2014 to March 2015 were studied retrospectively by analyzing the clinical characteristics, radiological features and DST results. A total of 201 NMLD patients [male 108, age(58±15) yrs] were enrolled into this study including 48 cases of [male 13, age (52±16) yrs],46 cases of [male 46, age (57±16) yrs], 92 cases of [male 43, age (61±13) yrs], and 15 cases of [male 6, age (67±10) yrs]. Read More

Respir Res 2019 Dec 3;20(1):271. Epub 2019 Dec 3.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, 101 Daehak-Ro Jongno-Gu, Seoul, 03080, Republic of Korea.

Background: All-cause mortality risk and causes of death in bronchiectasis patients have not been fully investigated. The aim of this study was to compare the mortality risk and causes of death between individuals with bronchiectasis and those without bronchiectasis.

Methods: Patients with or without bronchiectasis determined based on chest computed tomography (CT) at one centre between 2005 and 2016 were enrolled. Read More

Drugs Aging 2020 01;37(1):11-18

Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties, University of Palermo, Piazza delle Cliniche, 2, 90100, Palermo, Italy.

The increase in life expectancy together with better care of rheumatoid arthritis (RA) has led to higher proportions of elderly individuals with RA. This has challenged the treatment of the disease in older aged patients, usually characterized by comorbid conditions and polypharmacy. Overall, the lung involvement in RA is present in up to 80% of patients, depending on the assessment tools used, and interstitial abnormalities are among the most common; when present, interstitial lung disease (ILD) worsens the prognosis of RA, and is the second most common cause of mortality. Read More

Clin Respir J 2020 Feb 5;14(2):140-147. Epub 2019 Dec 5.

Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Introduction: The characteristics of Allergic Bronchopulmonary Aspergillosis (ABPA) based on its radiological classification is still unclear.

Objectives: To investigate the clinical significances of ABPA patients with central bronchiectasis (ABPA-CB) by different radiological classifications of mucus plugs.

Methods: ABPA-CB patients from a pulmonary hospital between 2008 and 2015 were retrospectively included and analysed. Read More

Am J Respir Crit Care Med 2020 Mar;201(6):688-696

Telethon Kids Institute and.

Recent data show that species are prevalent respiratory infections in children with cystic fibrosis (CF). The biological significance of these infections is unknown. We aimed to evaluate longitudinal associations between infections and lung disease in young children with CF. Read More

Eur Ann Otorhinolaryngol Head Neck Dis 2020 Mar 14;137(2):135-137. Epub 2019 Nov 14.

Service de pneumologie, pôle de pathologie thoracique, hôpitaux universitaires de Strasbourg, 1, place de l'Hôpital, 67000 Strasbourg, France; Service ORL-CCF, hôpital de Hautepierre, hôpitaux universitaire de Strasbourg, 1, avenue Molière, 67098 Strasbourg cedex, France. Electronic address:

Introduction: We report a case of an exceptional syndromic association of apparently congenital rhinobronchial dystrophy associated with congenital anosmia and common variable immunodeficiency in a twelve-year-old girl.

Case Summary: This young girl, born in 2000, consulted for the first time in 2012 for recurrent respiratory tract infections, refractory to all forms of treatment, starting in early childhood, associated with congenital anosmia and severe atrophic rhinitis as well as common variable immunodeficiency. The laboratory work-up essentially revealed IgG4 deficiency and imaging demonstrated bronchiectasis (lingula), multiple tracheobronchial diverticula, atrophic rhinitis and congenital anosmia with agenesis of the olfactory bulbs and sulci. Read More

Zhonghua Jie He He Hu Xi Za Zhi 2019 Nov;42(11):852-857

Department of Respiratory and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Beijing 100730, China.

To analyze the clinical,imaging and pathological features of Pleuroparenehymal fibroelastosis (PPFE). The clinieal data of a patient diagnosed as PPFE admitted in department of Respiratory and Critical Care Medicine,Beijing Hospital in April 2017 were reported and the related literatures were reviewed.With "pleuroparenehymal fibroelastosis" as the search terms, and the search time before October 1st 2017 for Wanfangdata, China National Knowledge Infrastructure(CNKI), and PubMed. Read More