12,649 results match your criteria Bronchiectasis Imaging


Health Perception and Behaviors in Adults With Bronchiectasis.

Respir Care 2018 Dec 11. Epub 2018 Dec 11.

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, China.

Background: Bronchiectasis is a chronic debilitating suppurative disease that significantly impacts quality of life. Clinical outcomes like exacerbations, are usually physician centered; however, the patients' experience, health-related behaviors, and expectations have frequently been neglected. In addition, patients' health perceptions may be influenced by their culture. Read More

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December 2018

Coronary-to-bronchial artery fistula in a patient with angina.

J Cardiol Cases 2013 Feb 5;7(2):e45-e47. Epub 2012 Dec 5.

UO Cardiologia Adulti, Fondazione Toscana Gabriele Monasterio, Massa, Italy.

Coronary-to-bronchial artery fistulae are the most common found in adulthood and have often been associated with bronchiectasis and other abnormalities of pulmonary parenchyma. In this study we describe an unusual case in which circumflex coronary artery-to-left bronchial artery fistula was associated with the presence of extensive aneurysmatic dilatation of thoracic arteries. <: This report deals with the case of a coronary-to-bronchial artery fistula (CAF) as the cause of atypical angina in a patient with normal coronary arteries. Read More

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February 2013

Allergic bronchopulmonary aspergillosis successfully treated with mepolizumab: Case report and review of the literature.

Respir Med Case Rep 2019 24;26:59-62. Epub 2018 Nov 24.

Department of Respiratory Medicine, Saitama Cardiovascular and Respiratory Center, Japan.

A 56-year-old woman was referred to our hospital for recurrent asthma of 20 years duration. She was diagnosed as having allergic bronchopulmonary aspergillosis on the basis of clinical symptoms, peripheral blood eosinophilia, elevated total serum immunoglobulin E value, positive results of specific IgE and precipitating antibodies against sp., central bronchiectasis, and mucoid impaction. Read More

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November 2018

The association between computed tomography scan findings of pulmonary infection caused by atypical mycobacteria and bacillus count in sputum samples.

Int J Mycobacteriol 2018 Oct-Dec;7(4):355-357

Pediatric Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: The use of imaging techniques is important for prompt diagnosis and treatment of atypical mycobacterial infections; it also reduces the burden of these infections. The purpose of the present study was to determine the association between computed tomography (CT) scan findings of pulmonary infection caused by atypical mycobacteria and bacillus count in sputum samples.

Methods: This cross-sectional, observational, comparative study included 50 consecutive patients with pulmonary infection caused by atypical mycobacteria, who were hospitalized in Masih-Daneshvari Hospital of Tehran, Iran during 2012-2017. Read More

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December 2018

Traction bronchiectasis on high-resolution computed tomography may predict fatal acute eosinophilic pneumonia.

Respir Investig 2018 Oct 24. Epub 2018 Oct 24.

Department of Respiratory Medicine, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama 710-8602, Japan.

Background: Most patients with acute eosinophilic pneumonia (AEP) show rapid improvement. However, some cases of AEP prove fatal. The aims of this study were to determine the clinical, radiographic, and pathologic characteristics of patients in whom AEP has a fatal outcome and to identify predictors of a poor prognosis. Read More

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October 2018

New Insights Into the Epidemiology of Bronchiectasis.

Authors:
James D Chalmers

Chest 2018 Dec;154(6):1272-1273

Scottish Centre for Respiratory Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland. Electronic address:

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December 2018

[Respiratory manifestations in primary immunodeficiencies].

Authors:
Zoltán Nyul

Orv Hetil 2018 Dec;159(49):2043-2049

Klinikai Központ, Gyermekgyógyászati Klinika, Pécsi Tudományegyetem, Általános Orvostudományi Kar Pécs, József Attila u. 7., 7623.

The respiratory infections are the most common presentations and leading cause of morbidity and mortality in primary immunodeficiencies. The pathogen or spectrum of pathogens may be characteristic for the underlying primary immunodeficiency, and that knowledge plays an important role in the empirical treatment or prevention of the infections, or, conversely, the identification of an unusual pathogen may raise the suspicion on an immunodeficiency. Apart from the acute respiratory infections, chronic lung diseases are also common complications. Read More

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December 2018

Loss of ARHGEF1 causes a human primary antibody deficiency.

J Clin Invest 2018 Dec 6. Epub 2018 Dec 6.

ARHGEF1 is a RhoA-specific guanine nucleotide exchange factor expressed in hematopoietic cells. We used whole-exome sequencing to identify compound heterozygous mutations in ARHGEF1, resulting in the loss of ARHGEF1 protein expression in two primary-antibody-deficient siblings presenting with recurrent severe respiratory tract infections and bronchiectasis. Both ARHGEF1-deficient patients showed an abnormal B cell immunophenotype, with a deficiency in marginal-zone and memory B cells and an increased frequency of transitional B cells. Read More

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December 2018

[Individualised treatment of patients with bronchoectasis].

Ugeskr Laeger 2018 Dec;180(49)

Bronchiectasis is characterised by chronic cough, airway inflammation, infection and bronchial dilatation. The disease may lead to impaired lung function and premature death. An underlying inflammatory disease or immunodeficiency may be present, but 40% of the cases are idiopathic. Read More

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December 2018

Mucolytic Agents and Statins Use is Associated with a Lower Risk of Acute Exacerbations in Patients with Bronchiectasis-Chronic Obstructive Pulmonary Disease Overlap.

J Clin Med 2018 Dec 4;7(12). Epub 2018 Dec 4.

Department of Family Medicine, Taipei Veterans General Hospital, Taipei 11217, Taiwan.

Background: Bronchiectasis-chronic obstructive pulmonary disease (COPD) overlap (BCO) is a neglected area of trials, and it is not covered by guidelines for clinical practice.

Methods: Using the National Health Insurance Research Database of Taiwan, COPD patients with or without bronchiectasis from 2000 to 2009 were enrolled as the BCO and COPD alone cohorts, respectively. Patients followed for <28 days, diagnosed with COPD who were not prescribed with COPD medications, and those diagnosed with bronchiectasis who did not receive a chest X-ray or computed tomography were excluded. Read More

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December 2018

Surgical management of non-cystic fibrosis bronchiectasis.

J Thorac Dis 2018 Oct;10(Suppl 28):S3436-S3445

Section of Chest Surgery, Fukujuji Hospital, Tokyo, Japan.

Non-cystic fibrosis bronchiectasis (bronchiectasis) is an abnormal dilatation of the bronchi and bronchioles, resulting from a prolonged recurrent infectious process due to various causes and predisposing factors. This disease has several etiologies and affects a heterogeneous population of patients. The most important viewpoint for the surgical management of bronchiectasis is to select appropriate candidates for surgery and conduct suitable anatomic lung resections at the right time under appropriate conditions. Read More

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October 2018
1 Read

Medical management of bronchiectasis.

Authors:
Anne E O'Donnell

J Thorac Dis 2018 Oct;10(Suppl 28):S3428-S3435

Division of Pulmonary, Critical Care and Sleep Medicine, Georgetown University Medical Center, Washington, DC, USA.

The medical management of bronchiectasis includes confirming the diagnosis of the disease, evaluating the patient for possible underlying etiologies and then properly assessing the patient for appropriate therapies. Patients with bronchiectasis are heterogeneous and a personalized approach to each patient is needed in order to properly formulate an optimal management plan. Read More

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October 2018

Bronchiectasis after bronchial thermoplasty.

J Thorac Dis 2018 Oct;10(10):E721-E726

Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.

Bronchial thermoplasty (BT) is used in the treatment of severe refractory asthma. It has been found to be beneficial to long-term improvements in the rate of asthma exacerbation, quality of life questionnaire answers (AQLQ), hospitalization, and emergency room visits. Atelectasis and lung abscess as direct complication of BT, but not bronchiectasis, have been reported previously. Read More

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October 2018

CT findings in pulmonary alveolar proteinosis: serial changes and prognostic implications.

J Thorac Dis 2018 Oct;10(10):5774-5783

Department of Radiology, Samsung Medical Center, Seoul, Korea.

Background: Pulmonary alveolar proteinosis (PAP) is a rare disease of unknown origin, characterized by impaired surfactant metabolism. In some patients, residual disease is observed after treatment; notably, this may progress to end-stage pulmonary fibrosis. This study was performed to evaluate changes in lung abnormalities on serial CT scans performed on the lungs of patients diagnosed with PAP, as well as to identify factors that can be used to predict clinical improvement in PAP. Read More

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October 2018

HTLV-1 is rare in Far North Queensland despite a significant burden of classically associated diseases.

Pathology 2018 Nov 28. Epub 2018 Nov 28.

Department of Medicine, Cairns Hospital, Cairns, Qld, Australia; The Kirby Institute, University of New South Wales, Kensington, NSW, Australia.

Human T-lymphotropic virus type 1 (HTLV-1) is hyperendemic amongst Indigenous Australians living in Central Australia. The epidemiology of the disease is poorly defined in other parts of Australia, despite a high prevalence of classically associated conditions. All HTLV-1 serology tests requested through public health facilities in Far North Queensland (FNQ) from January 1999 to December 2016 were reviewed. Read More

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November 2018

The patient profile of individuals with Alpha-1 antitrypsine gene mutations at a referral center in Brazil.

J Bras Pneumol 2018 Sep-Oct;44(5):383-389

. Pulmonology Division, Instituto do Coração, Hospital das Clínicas, School of Medicine, Universidade de São Paulo, São Paulo (SP) Brazil.

Objective: The clinical, functional, radiological and genotypic descriptions of patients with an alpha-1 antitrypsin (A1AT) gene mutation in a referral center for COPD in Brazil.

Methods: A cross-sectional study of patients with an A1AT gene mutation compatible with deficiency. We evaluated the A1AT dosage and genotypic, demographic, clinical, tomographic, and functional characteristics of these patients. Read More

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November 2017

Pulmonary high-resolution computed tomography findings in patients with synovitis, acne, pustulosis, hyperostosis and osteitis syndrome.

PLoS One 2018 5;13(12):e0206858. Epub 2018 Dec 5.

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Objective: To characterize the high-resolution computed tomography (HRCT) pulmonary abnormalities in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome.

Methods: Pulmonary HRCT images were reconstructed from whole-spine computed tomography (CT) images of 67 patients with SAPHO syndrome. HRCT images of 58 healthy controls were also obtained and reviewed. Read More

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December 2018

Bronchiectasis and asthma: a dangerous liaison?

Curr Opin Allergy Clin Immunol 2018 Dec 3. Epub 2018 Dec 3.

Respiratory Medicine Unit, A.O.U. 'Policlinico-Vittorio Emanuele', Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.

Purpose Of Review: To explore the latest insight of the literature on the asthma/bronchiectasis phenotype providing an updated overview about epidemiological, clinical and biological evidence linking these two conditions.

Recent Findings: An increasing body of literature has shown that the association of asthma and bronchiectasis is a frequent phenomenon leading to a more severe disease with frequent exacerbations. The mechanisms by which the two diseases are linked are still not well established but they share several clinical and immunological features and many comorbidities. Read More

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December 2018

Recurrence of allergic bronchopulmonary aspergillosis after adjunctive surgery for aspergilloma: a case report with long-term follow-up.

BMC Pulm Med 2018 Dec 4;18(1):185. Epub 2018 Dec 4.

Department of Pulmonary Medicine, Eiju General Hospital, 2-23-16 Higashi Ueno, Taito-ku, Tokyo, 110-8645, Japan.

Background: Coexistence of aspergilloma and allergic bronchopulmonary aspergillosis (ABPA) has rarely been reported. Although the treatment for ABPA includes administration of corticosteroids and antifungal agents, little is known about the treatment for coexisting aspergilloma and ABPA. Furthermore, the impact of surgical resection for aspergilloma on ABPA is not fully understood. Read More

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December 2018
1 Read

pneumonia with hemoptysis: A case report.

Respir Med Case Rep 2019 9;26:31-34. Epub 2018 Nov 9.

Department of Pulmonary Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

, which colonizes upper respiratory and digestive tracts, is a leading cause of respiratory diseases in many host species. Here, we describe a case of pneumonia with hemoptysis. A 72-year-old female diagnosed with bronchiectasis with a 36-year history presented with a worsened infiltrative and granular shadow in the lower right lobe and lingular segment. Read More

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November 2018
1 Read

Relative risk of all-cause mortality in patients with nontuberculous mycobacterial lung disease in a US managed care population.

Respir Med 2018 Dec 22;145:80-88. Epub 2018 Oct 22.

Pulmonary Branch/NHLBI, National Institutes of Health, Bethesda, MD, USA.

Rationale: The risk of all-cause mortality of nontuberculous mycobacterial lung disease (NTMLD) in the United States (US) population is not well established.

Objectives: This study aims to assess the public health burden of NTMLD in the US by comparing the relative risk of all-cause mortality in the NTMLD population with an age- and sex-matched cohort from the general population.

Methods: Patients with physician claims for NTMLD (ICD-9 0. Read More

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December 2018
2 Reads

Quality control for multiple breath washout tests in multicentre bronchiectasis studies: Experiences from the BRONCH-UK clinimetrics study.

Respir Med 2018 Dec 1;145:206-211. Epub 2018 Nov 1.

The Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, UK.

Introduction: Multiple Breath Washout (MBW) to measure Lung Clearance Index (LCI) is increasingly being used as a secondary endpoint in multicentre bronchiectasis studies. LCI data quality control or "over-reading" is resource intensive and the impact is unclear.

Objectives: To assess the proportion of MBW tests deemed unacceptable with over-reading, and to assess the change in LCI (number of turnovers), LCI coefficient of variation (CV%) and tidal volume (VT) CV% results after over-reading. Read More

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December 2018
1 Read

A comprehensive approach to lung function in bronchiectasis.

Respir Med 2018 Dec 2;145:120-129. Epub 2018 Nov 2.

Department of Pathophysiology and Transplantation, University of Milan, Internal Medicine Department, Respiratory Unit and Cystic Fibrosis Adult Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy; School of Medicine, University of Milan Bicocca, Respiratory Unit, AO San Gerardo, Monza, Italy. Electronic address:

Background: International guidelines recommend simple spirometry for bronchiectasis patients. However, pulmonary pathophysiology of bronchiectasis is very complex and still poorly understood. Our objective was to characterize lung function in bronchiectasis and identify specific functional sub-groups. Read More

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December 2018

Paediatric and adult bronchiectasis: Monitoring, cross-infection, role of multidisciplinary teams and self-management plans.

Respirology 2018 Nov 30. Epub 2018 Nov 30.

Child Health Division, Menzies School of Health Research, Darwin, NT, Australia.

Bronchiectasis is a chronic lung disease associated with structurally abnormal bronchi, clinically manifested by a persistent wet/productive cough, airway infections and recurrent exacerbations. Early identification and treatment of acute exacerbations is an integral part of monitoring and annual review, in both adults and children, to minimize further damage due to infection and inflammation. Common modalities used to monitor disease progression include clinical signs and symptoms, frequency of exacerbations and/or number of hospital admissions, lung function (forced expiratory volume in 1 s (FEV )% predicted), imaging (radiological severity of disease) and sputum microbiology (chronic infection with Pseudomonas aeruginosa). Read More

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November 2018
3 Reads

The European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) ERS Clinical Research Collaboration.

Eur Respir J 2018 Nov 29;52(5). Epub 2018 Nov 29.

Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Respiratory Unit and Adult Cystic Fibrosis Center, Dept of Pathophysiology and Transplantation, University of Milan, Milan, Italy.

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November 2018
1 Read

Pulmonary vascular pruning in smokers with bronchiectasis.

ERJ Open Res 2018 Oct 23;4(4). Epub 2018 Nov 23.

Dept of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

There are few studies looking at the pulmonary circulation in subjects with bronchiectasis. We aimed to evaluate the intraparenchymal pulmonary vascular structure, using noncontrast chest computed tomography (CT), and its clinical implications in smokers with radiographic bronchiectasis. Visual bronchiectasis scoring and quantitative assessment of the intraparenchymal pulmonary vasculature were performed on CT scans from 486 smokers. Read More

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October 2018
5 Reads

Randomised controlled trial of cognitive behavioural therapy in COPD.

ERJ Open Res 2018 Oct 23;4(4). Epub 2018 Nov 23.

Institute of Cellular Medicine, Medical School, Newcastle University, Newcastle upon Tyne, UK.

Anxiety is an important comorbidity in chronic obstructive pulmonary disease (COPD). We investigated if cognitive behavioural therapy (CBT), delivered by respiratory nurses, reduced symptoms of anxiety and was cost-effective. Patients with COPD and anxiety were randomised to CBT or self-help leaflets. Read More

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October 2018
3 Reads

Paediatric and adult bronchiectasis: Vaccination in prevention and management.

Respirology 2018 Nov 26. Epub 2018 Nov 26.

School of Medicine, Griffith University, Gold Coast, QLD, Australia.

Bronchiectasis has received increased attention recently, including an emphasis on preventing infective exacerbations that are associated with disease progression and lung function decline. While there are several bacteria and viruses associated with bronchiectasis, licensed vaccines are only currently available for Streptococcus pneumoniae, Haemophilus influenzae (H. influenzae protein D as a conjugate in a pneumococcal vaccine), Mycobacterium tuberculosis, Bordetella pertussis and influenza virus. Read More

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November 2018
5 Reads

[Features distinguishing ornithosis from avian acute hypersensitivity pneumonitis - a retrospective analysis].

Rev Mal Respir 2018 Nov 22. Epub 2018 Nov 22.

Service des maladies infectieuses et de réanimation médicale, CHU de Rennes, 35043 Rennes, France; Inserm-CIC-1414, faculté de médecine, IFR 140, université de Rennes I, 35033 Rennes, France.

Introduction: The aim of our study was to compare the features at diagnosis in patients with ornithosis to patients with avian acute hypersensitivity pneumonitis (HP). Clinical, biological and radiological differences could potentially help clinicians to distinguish these diseases.

Methods: We conducted a retrospective study on patients admitted from 2000 to 2016 in three hospitals. Read More

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November 2018
1 Read

Atypical Mycobacteria in Bronchiectasis. When do we Treat it?

Arch Bronconeumol 2018 Nov 21. Epub 2018 Nov 21.

Hospital Universitari Vall d'Hebron (HUVH), Institut de Recerca Vall d'Hebron (VHIR), Barcelona, España; Servicio de Neumología, Hospital Universitari Vall d'Hebron (HUVH), CIBER, Barcelona, España. Electronic address:

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November 2018

Heterogeneity and complexity in bronchiectasis: A pending challenge.

Arch Bronconeumol 2018 Nov 20. Epub 2018 Nov 20.

Institut Respiratori, Hospital Clinic, University Barcelona, IDIBAPS, CIBERES, Barcelona, España.

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November 2018

COPD Assessment Test (CAT) is a Valid and Simple Tool to Measure the Impact of Bronchiectasis on Affected Patients.

COPD 2018 Nov 23:1-8. Epub 2018 Nov 23.

a Postgraduate Program in Rehabilitation Sciences , Universidade Nove de Julho - UNINOVE , São Paulo , Brazil.

The COPD assessment test (CAT) is a short questionnaire developed to help patients and clinicians to assess the impact of symptoms in routine clinical practice. We aimed to validate and to test the reproducibility of CAT in patients with bronchiectasis and correlate with the severity of dyspnea, aerobic and functional capacity, and physical activity in daily life. This is a cross-sectional study, patients with bronchiectasis underwent spirometry, cardiopulmonary exercise test (CPET), incremental shuttle walk test (ISWT), Saint George`s Respiratory Questionnaire (SGRQ), and received pedometer. Read More

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November 2018
2 Reads

Bronchiectasis in severe asthma: a distinct phenotype?

Curr Opin Pulm Med 2019 Jan;25(1):71-78

Cystic Fibrosis and primary immunodeficiencies Unit, Institut de Recerca Vall d'Hebron (VHIR).

Purpose Of Review: The presence of bronchiectasis has been described in about 30% of severe asthma patients. The coexistence of these two respiratory conditions poses new challenges from both clinical and research perspectives. We will review the available literature on this topic to discuss the existance of a specific clinical phenotype of asthma. Read More

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January 2019
5 Reads

Management of Non-Cystic Fibrosis Bronchiectasis.

Consult Pharm 2018 Nov;33(11):658-666

The purpose of this report is to describe the case of a 43-year-old male with asthma who was hospitalized for an exacerbation of non-cystic fibrosis bronchiectasis (NCFB), a chronic lung disease that is characterized by dilation of the airways, persistent cough, chronic sputum production, and recurrent respiratory infections. He was treated with oral and inhaled antibiotics, inhaled bronchodilators, and aggressive airway-clearance techniques including nebulized 7% sodium chloride, flutter valve, and high-frequency chest wall oscillation. Community pharmacy, nursing facility pharmacy, consultant pharmacy practice. Read More

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November 2018
1 Read

Surgical Treatment of Pulmonary Nontuberculous Mycobacterial Infections.

Authors:
John D Mitchell

Thorac Surg Clin 2019 Feb;29(1):77-83

Section of General Thoracic Surgery, Division of Cardiothoracic Surgery, University of Colorado School of Medicine, Academic Office 1, Room 6602, C-310, 12631 East 17th Avenue, Aurora, CO 80045, USA. Electronic address:

Adjuvant surgical resection in the setting of pulmonary nontuberculous mycobacterial (NTM) infection removes focal parenchymal disease thought to serve as a poorly perfused "reservoir" for organisms, thus resistant to standard antimicrobial therapy. Removal of these areas of damaged lung is felt to enhance the effectiveness of the medical treatment. In general, these operations are associated with low morbidity and mortality, although resections that are more extensive carry higher risk. Read More

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February 2019
5 Reads

Microscopic polyangiitis secondary to Mycobacterium abscessus in a patient with bronchiectasis: a case report.

BMC Pulm Med 2018 Nov 19;18(1):170. Epub 2018 Nov 19.

Centre for Experimental Medicine, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland.

Background: Non-Tuberculous Mycobacterial-pulmonary disease (NTM-PD) is increasing in incidence and prevalence. Mycobacterium abscessus (M.abscessus) is a rapid growing multi-resistant NTM associated with severe NTM-PD requiring prolonged antibiotic therapy. Read More

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November 2018
5 Reads

[The start of the Hungarian lung transplantation program and the first results].

Orv Hetil 2018 Nov;159(46):1859-1868

Mellkassebészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest.

The first lung transplantation in Hungary was performed on 12th of December, 2015. It was a joint effort of the National Institute of Oncology and the Semmelweis University. Hereby we summarise the results and experiences from the first three years. Read More

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November 2018
1 Read

Bronchial artery embolization in treatment of hemoptysis: Treatment efficacy and complications at a tertiary care chest centre.

Med J Armed Forces India 2018 Oct 28;74(4):352-357. Epub 2017 Oct 28.

Associate Professor, Dept of Community Medicine & Epidemiologist, Armed Forces Medical College, Pune 411040, India.

Background: Hemoptysis is one of the most alarming condition to both the patients suffering from it and the treating physicians. It is caused due to varied etiologies. One of the emergent and at times life-saving treatment option is by minimally invasive interventional radiological technique of Bronchial Atery Embolization (BAE). Read More

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October 2018
4 Reads

An Unusual Case of Acute Cholecystitis with Amyloidosis: A Case Report and Literature Review.

Intern Med 2018 Nov 19. Epub 2018 Nov 19.

Department of Gastroenterology, Kyoto City Hospital, Japan.

We present an extremely rare case of amyloid A (AA) deposition in the gallbladder and review the literature on similar cases. The patient was a 76-year-old man who had been diagnosed with mild bronchiectasis three years previously, who was admitted to the hospital with right upper quadrant pain and fever. Computed tomography revealed swelling and wall thickening of the gallbladder with a small gallstone. Read More

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November 2018
4 Reads

Clinical Features of anti-MDA5 Antibody-positive Rapidly Progressive Interstitial Lung Disease without Signs of Dermatomyositis: A Case Series.

Intern Med 2018 Nov 19. Epub 2018 Nov 19.

Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan.

Anti-melanoma differentiation-associated gene 5 (anti-MDA5) antibody is associated with rapidly progressive interstitial lung disease (RP-ILD) in patients with clinically amyopathic dermatomyositis (CADM) or dermatomyositis (DM). We herein report three Japanese cases of anti-MDA5 antibody-positive RP-ILD without signs of CADM or DM. High-resolution computed tomography revealed patchy or subpleural distribution of consolidations and/or ground-glass opacities accompanied by traction bronchiectasis. Read More

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November 2018
4 Reads

: Shapeshifter of the Mycobacterial World.

Front Microbiol 2018 1;9:2642. Epub 2018 Nov 1.

Department of Medicine, The University of New Mexico School of Medicine, Albuquerque, NM, United States.

In this review we will focus on unique aspects of () which we feel earn it the designation of "shapeshifter of the mycobacterial world." We will review its emergence as a distinct species, the recognition and description of subspecies which are only now being clearly defined in terms of pathogenicity, its ability to exist in different forms favoring a saprophytic lifestyle or one more suitable to invasion of mammalian hosts, as well as current challenges in terms of antimicrobial therapy and future directions for research. One can see in the various phases of , a species transitioning from a free living saprophyte to a host-adapted pathogen. Read More

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November 2018
4 Reads

Bronchiectasis.

Nat Rev Dis Primers 2018 Nov 15;4(1):45. Epub 2018 Nov 15.

Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL, USA.

Bronchiectasis refers to abnormal dilatation of the bronchi. Airway dilatation can lead to failure of mucus clearance and increased risk of infection. Pathophysiological mechanisms of bronchiectasis include persistent bacterial infections, dysregulated immune responses, impaired mucociliary clearance and airway obstruction. Read More

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November 2018
7 Reads

Bronchiectasis.

Authors:

Nat Rev Dis Primers 2018 Nov 15;4(1):46. Epub 2018 Nov 15.

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November 2018

Emerging Concepts and Therapies for Mucoobstructive Lung Disease.

Ann Am Thorac Soc 2018 Nov;15(Supplement_3):S216-S226

4 Marsico Lung Institute, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina.

A spectrum of intrapulmonary airway diseases, for example, cigarette smoke-induced bronchitis, cystic fibrosis, primary ciliary dyskinesia, and non-cystic fibrosis bronchiectasis, can be categorized as "mucoobstructive" airway diseases. A common theme for these diseases appears to be the failure to properly regulate mucus concentration, producing mucus hyperconcentration that slows mucus transport and, importantly, generates plaque/plug adhesion to airway surfaces. These mucus plaques/plugs generate long diffusion distances for oxygen, producing hypoxic niches within adherent airway mucus and subjacent epithelia. Read More

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November 2018
7 Reads

Airway Epithelial Differentiation and Mucociliary Clearance.

Ann Am Thorac Soc 2018 Nov;15(Supplement_3):S143-S148

Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

The lung is continuously exposed to particles, toxicants, and microbial pathogens that are cleared by a complex mechanical, innate, and acquired immune system. Mucociliary clearance, mediated by the actions of diverse conducting airway and submucosal gland epithelial cells, plays a critical role in a multilayered defense system by secreting fluids, electrolytes, antimicrobial and antiinflammatory proteins, and mucus onto airway surfaces. The mucociliary escalator removes particles and pathogens by the mechanical actions of cilia and cough. Read More

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November 2018
16 Reads

: A potential pulmonary pathogen isolated from multiple patients with bronchiectasis in the United States including the first case of clinical disease in a patient with Cystic Fibrosis.

J Clin Microbiol 2018 Nov 14. Epub 2018 Nov 14.

Mycobacteria/Nocardia Research Laboratory, Department of Microbiology, The University of Texas Health Science Center at Tyler, Tyler, TX, USA.

We characterize three respiratory isolates of the recently described species recovered in Texas, Louisiana, and Massachusetts, including the first case of disease in a patient with underlying cystic fibrosis. The three isolates had a 100% match to NE-TNMC-100812 by complete 16S rRNA, - region V, and 65 gene sequencing. Core genomic comparisons between one isolate and the type strain revealed an average nucleotide identity of 99. Read More

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November 2018

Persistent eosinophilia in rheumatoid arthritis: a prospective observational study.

Rheumatol Int 2018 Nov 13. Epub 2018 Nov 13.

Department of Clinical Immunology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605006, India.

Eosinophilia is an uncommon manifestation in Rheumatoid arthritis (RA), and there is a paucity of data regarding the relationship of eosinophilia with disease-related factors. We prospectively evaluated the clinical and disease-specific characteristics of RA patients with eosinophilia. Consecutive patients with RA with an absolute eosinophil count ≥ 500/mm without an apparent cause for eosinophilia, were investigated for parasitic infestation. Read More

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November 2018
4 Reads
1.630 Impact Factor

The Immune Mechanisms of Lung Parenchymal Damage in Tuberculosis and the Role of Host-Directed Therapy.

Front Microbiol 2018 30;9:2603. Epub 2018 Oct 30.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.

Impaired lung function is common in people with a history of tuberculosis. Host-directed therapy added to tuberculosis treatment may reduce lung damage and result in improved lung function. An understanding of the pathogenesis of pulmonary damage in TB is fundamental to successfully predicting which interventions could be beneficial. Read More

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October 2018
7 Reads

Characterization of Microbiota in Bronchiectasis Patients with Different Disease Severities.

J Clin Med 2018 Nov 9;7(11). Epub 2018 Nov 9.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine Seoul National University Bundang Hospital, 82 Gumi-ro, 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707, Korea.

The applications of the 16S rRNA gene pyrosequencing has expanded our knowledge of the respiratory tract microbiome originally obtained using conventional, culture-based methods. In this study, we employed DNA-based molecular techniques for examining the sputum microbiome in bronchiectasis patients, in relation to disease severity. Of the sixty-three study subjects, forty-two had mild and twenty-one had moderate or severe bronchiectasis, which was classified by calculating the FACED score, based on the FEV₁ (forced expiratory volume in 1 s, %) (F, 0⁻2 points), age (A, 0⁻2 points), chronic colonization by (C, 0⁻1 point), radiographic extension (E, 0⁻1 point), and dyspnoea (D, 0⁻1 point). Read More

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November 2018
3 Reads