Search Our Scientific Publications & Authors

Chron Respir Dis 2022 Jan-Dec;19:14799731221105517

Capital Medical University, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.

Background And Objective: Many bronchiectasis patients suffer dyspnea, decreased exercise tolerance, and low body mass index. Chest wall muscles play a special role in respiratory movement and make up parts of skeletal muscles. This study aimed to examine the chest wall muscle thickness and their relationship with disease severity in bronchiectasis. Read More

Invest Radiol 2022 May 6. Epub 2022 May 6.

From the Department of Radiology, Mayo Clinic, Rochester, MN.

Objective: The aim of this study was to evaluate the clinical impact of a higher spatial resolution, full field-of-view investigational photon-counting detector computed tomography (PCD-CT) on radiologist confidence in imaging findings and diagnosis of usual interstitial pneumonia (UIP) compared with conventional energy-integrating detector CT (EID-CT).

Materials And Methods: Patients suspected of interstitial lung disease were scanned on a PCD-CT system after informed consent and a clinically indicated EID-CT. In 2 sessions, 3 thoracic radiologists blinded to clinical history and scanner type evaluated CT images of the right and left lungs separately on EID- or PCD-CT, reviewing each lung once/session, rating confidence in imaging findings of reticulation, traction bronchiectasis, honeycombing, ground-glass opacities (GGOs), mosaic pattern, and lower lobe predominance (100-point scale: 0-33, likely absent; 34-66, indeterminate; 67-100, likely present). Read More

BMJ Open 2022 Jun 13;12(6):e059110. Epub 2022 Jun 13.

Instituto do Coração-Divisão de Pneumologia, Universidade de São Paulo Hospital das Clínicas, Sao Paulo, Brazil.

Objective: This study aimed to propose a simple, accessible and low-cost predictive clinical model to detect lung lesions due to COVID-19 infection.

Design: This prospective cohort study included COVID-19 survivors hospitalised between 30 March 2020 and 31 August 2020 followed-up 6 months after hospital discharge. The pulmonary function was assessed using the modified Medical Research Council (mMRC) dyspnoea scale, oximetry (SpO), spirometry (forced vital capacity (FVC)) and chest X-ray (CXR) during an in-person consultation. Read More

Expert Rev Respir Med 2022 Jun 16:1-9. Epub 2022 Jun 16.

Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, Haidian, China.

Background: Bronchiectasis was reported in 2%-40% of patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV), but there were no studies on the prevalence, risk factors and impact of AAV-associated bronchiectasis in Chinese patients.

Research Design And Methods: AAV patients were retrospectively enrolled. The clinical, laboratory and imaging features and the prognosis were analyzed and compared between those with and without bronchiectasis. Read More

Int J Clin Pract 2022 31;2022:8773204. Epub 2022 Jan 31.

Department of Thoracic Surgery, Inonu University School of Medicine, Malatya, Turkey.

Background: Bronchiectasis is still a challenging chronic lung disease in developing countries. Patients with bronchiectasis can also have pulmonary hypertension. There are sparse data on the prevalence of pulmonary hypertension in patients with bronchiectasis. Read More

BMC Pulm Med 2022 Jun 2;22(1):214. Epub 2022 Jun 2.

Department of Respiratory and Critical Medicine, University-Town Hospital of Chongqing Medical University, Chongqing, 401331, China.

Background: Massive hemoptysis is a common and fatal complication of bronchiectasis. However, the risk factors for massive hemoptysis in patients with bronchiectasis have not yet been reported. This study investigated the potential risk factors for massive hemoptysis in patients with bronchiectasis. Read More

Tomography 2022 04 20;8(3):1184-1195. Epub 2022 Apr 20.

Department of Medicine and Surgery (DiMec), University of Parma, 43126 Parma, Italy.

Prior studies variably reported residual chest CT abnormalities after COVID-19. This study evaluates the CT patterns of residual abnormalities in severe COVID-19 pneumonia survivors. All consecutive COVID-19 survivors who received a CT scan 5-7 months after severe pneumonia in two Italian hospitals (Reggio Emilia and Parma) were enrolled. Read More

Radiology 2022 May 31:212584. Epub 2022 May 31.

From the Ctr for Pulmonary Functional Imaging, Dept of Radiology (A.H., T. Hino, T. Hida, M.N., V.I.V., G.M.H., H. Hatabu), Pulmonary and Critical Care Division (R.K.P., A.A.M., G.R.W., G.M.H.), Dept of Radiology (R.S.J.E.), and Channing Division of Network Medicine (M.H.C., E.K.S.), Brigham and Women's Hospital and Harvard Medical School, Boston, Mass; Dept of Radiology, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan (A.H., M.Y., N.T.); Dept of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan (T. Hida, H. Honda, K.I.); Dept of Radiology, Kansai Medical University, Hirakata, Japan (O.H.); Dept of Radiology, Keio University School of Medicine, Tokyo, Japan (Y.Y., M.J.); Dept of Radiology, Hospital of the University of Pennsylvania, Philadelphia, Pa (T.A.); Dept of Radiology, Kansai Rosai Hospital, Amagasaki, Japan (T.J.); Dept of Environmental Health, Harvard TH Chan School of Public Health, Boston, Mass (D.C.C.); and Dept of Radiology, National Jewish Health, Denver, Colo (D.A.L.).

Background The clinical impact of interstitial lung abnormalities (ILAs) on poor prognosis has been reported in many studies, but risk stratification in ILA will contribute to clinical practice. Purpose To investigate the association of traction bronchiectasis/bronchiolectasis index (TBI) with mortality and clinical outcomes in individuals with ILA by using the COPDGene cohort. Materials and Methods This study was a secondary analysis of prospectively collected data. Read More

J Clin Tuberc Other Mycobact Dis 2022 Aug 18;28:100318. Epub 2022 May 18.

Department of Internal Medicine, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan.

A previously healthy 13-year-old Japanese girl with a BCG vaccination history and no tuberculosis (TB) exposure history presented to the hospital with mild dyspnea for 1 month and fever for 5 days. Computed tomography showed consolidation with a pleural effusion, obstructed left main bronchus with an air bronchogram, and traction bronchiectasis of the left upper lobe (Fig. 1A, B). Read More

J Cardiothorac Surg 2022 May 26;17(1):130. Epub 2022 May 26.

Department of Thoracic Surgery, Queen Elizabeth Hospital, University Hospitals Birmingham, UHB Hospitals NHS Foundation Trust, Mindelsohn Way, Edgbaston, Birmingham, B15 2TH, England, UK.

Background: Bronchopulmonary sequestration (BPS) is a malformation of the lungs resulting in lung tissue lacking direct communication to the tracheobronchial tree. Most cases demonstrate systemic arterial blood supply from the descending thoracic aorta, the abdominal aorta, celiac axis or splenic artery and venous drainage via the pulmonary veins with occasional drainage into azygos vein. BPS is considered a childhood disease and accounts for 0. Read More

Respir Care 2022 07 24;67(7):842-849. Epub 2022 May 24.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota.

Background: Residual volume (RV) is a derived lung compartment that correlates with air trapping in the context of air flow obstruction on spirometry. The significance of an isolated elevation in RV in the absence of other pulmonary function test (PFT) abnormalities is not well defined. We sought to assess the clinical and radiologic findings associated with isolated elevation in RV. Read More

J Clin Med 2022 Apr 27;11(9). Epub 2022 Apr 27.

Department of Respiratory Therapy, College of Medicine, Chang Gung University, Taoyuan 33353, Taiwan.

Diffuse alveolar damage (DAD) is the pathological hallmark of acute respiratory distress syndrome (ARDS). DAD is independently correlated with higher mortality compared with the absence of DAD. Traction bronchiectasis in areas of ground-glass opacity or consolidation is associated with the late fibroproliferative or fibrotic phase of DAD. Read More

Radiology 2022 May 10:220019. Epub 2022 May 10.

Department of Radiology, Monaldi Hospital, AO dei Colli, Naples, Italy.

Background COVID-19 pneumonia may lead to pulmonary fibrosis in the long term. Chest CT is useful to evaluate changes in the lung parenchyma over time. Purpose To illustrate the temporal change of lung abnormalities on chest CT associated with COVID-19 pneumonia over 1-year. Read More

Radiol Clin North Am 2022 May;60(3):399-408

Department of Radiology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

Mycobacterial species other than Mycobacterium tuberculosis and Mycobacterium leprae constitute nontuberculous mycobacteria (NTM). NTM infections are on the rise, particularly in the Western world. They cause a wide range of pulmonary and systemic manifestations. Read More

Rom J Ophthalmol 2022 Jan-Mar;66(1):97-100

Department of Oculoplastic and Orbital Surgery, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

We present the case of a 35-year-old female patient, pregnant in her third trimester, with no ophthalmologic history of interest and a medical history of IgA deficiency syndrome with bronchiectasis as the only symptomatology, who came to another center with clinical symptoms of ocular discomfort. She was initially diagnosed with anterior uveitis and treated with topical and periocular corticosteroids. Edema and palpebral erythema appeared a few days later and she was diagnosed with idiopathic orbital inflammation and was treated with intravenous (I. Read More

Cureus 2022 Apr 4;14(4):e23810. Epub 2022 Apr 4.

Internal Medicine, University of North Texas, Denton, USA.

Tracheomegaly is a medical condition where the tracheal diameter is greater than the upper limits of normal. Tracheomegaly can be classified as primary or secondary. Primary tracheomegaly is usually congenital. Read More

Respirol Case Rep 2022 Jun 1;10(6):e0954. Epub 2022 May 1.

Monash Lung and Sleep Monash Medical Centre Clayton Victoria Australia.

We present a 43-year-old woman, with a history of allergic bronchopulmonary aspergillosis and a chronic bronchocoele, who was admitted to hospital with an infection of the bronchocoele, progressing to a pulmonary abscess and polymicrobial empyema, following dental extraction and regular probiotic ingestion. Interval chest imaging following this procedure demonstrated worsening right upper lobe opacities and a right-sided pleural effusion. Bronchoscopies identified copious mucoid secretions and an infected bronchocoele with a right upper lobe airways impaction. Read More

Front Microbiol 2022 18;13:868435. Epub 2022 Apr 18.

Department of Thoracic Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Background: The prevalence of nontuberculous mycobacteria (NTM) in patients with chronic respiratory disease has increased. The implication of NTM in non- bronchiectasis remained controversial. This study investigated the impact of NTM in non- bronchiectasis in Taiwan. Read More

BMC Pulm Med 2022 Apr 29;22(1):172. Epub 2022 Apr 29.

Deparment of Pathology, West Virginia University, Morgantown, WV, USA.

Background: Cigarette smoking is a risk factor for interstitial lung abnormalities (ILAs) and interstitial lung diseases (ILDs). Investigation defining the relationships between ILAs/ILDs and clinical, radiographic, and pathologic findings in smokers have been incomplete. Employing a cohort undergoing surgical resection for lung nodules/masses, we (1) define the prevalence of ILAs/ILDs, (2) delineate their clinical, radiographic and pathologic predictors, and (3) determine their associations with mortality. Read More

Monaldi Arch Chest Dis 2022 Apr 22. Epub 2022 Apr 22.

Department of Pulmonary Medicine, Nizam's Institute of Medical Sciences, Hyderabad.

Bronchocele is an abnormal accumulation of mucus often with associated bronchial dilatation. It can be due to either increased production or impaired drainage of mucus in the airways. Diseases like chronic bronchitis, bronchial asthma, bronchiectasis are characterized by high mucus production and other atypical conditions are bronchorrhea and plastic bronchitis with different physical characteristics and compositions of mucus. Read More

Radiology 2022 Apr 19:212547. Epub 2022 Apr 19.

From the Department of Radiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, Box 1234, New York, NY 10029.

Background Bronchiectasis is associated with loss of lung function, substantial use of health care resources, and increased morbidity and mortality in people with cardiopulmonary diseases. Purpose To assess the frequency and severity of bronchiectasis and related clinical findings of participants in a low-dose CT (LDCT) screening program. Materials and Methods The Early Lung and Cardiac Action Program (ELCAP) bronchiectasis score (range, 0-42; higher values indicate more severe bronchiectasis) was developed to facilitate bronchiectasis assessment. Read More

Medicina (B Aires) 2022 ;82(2):297-299

Servicio de Cirugía Torácica, Hospital Británico de Buenos Aires, Argentina.

Lung tumorlets are rare neuroendocrine neoplasms of 0.5 cm or less in diameter that extend beyond the basement membrane. Although they are associated with bronchiectasis and fibrosis they tend to be asymptomatic and behave in a benign way, usually being diagnosed as incidental microscopic nests of neuroendocrine cells in lung tissue. Read More

J Cyst Fibros 2022 Apr 7. Epub 2022 Apr 7.

Department of Diagnostic and Interventional Radiology, Subdivision of Pulmonary Imaging, University Hospital Heidelberg, Im Neuenheimer Feld 420, 69120 Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Im Neuenheimer Feld 156, 69120 Heidelberg, Germany; Department of Diagnostic and Interventional Radiology with Nuclear Medicine, Thoraxklinik at University Hospital Heidelberg, Röntgenstr. 1, 69126 Heidelberg, Germany. Electronic address:

Background: Therapy with Elexacaftor/Tezacaftor/Ivacaftor (ETI) was recently approved for adult cystic fibrosis (CF) patients with at least one F508del mutation. However, its effects on structural and functional lung abnormalities and chronic rhinosinusitis have not been studied by imaging.

Methods: 19 adults with CF (mean age 31±9y, range 19-55y) underwent standardized chest magnetic resonance imaging (MRI), and nine also same-session sinonasal MRI, before (MRI1) and after (MRI2) at least one month (mean duration 5 ± 3mon) on ETI. Read More

Acta Otorrinolaringol Esp (Engl Ed) 2022 Mar-Apr;73(2):133-134

Hospital Universitario Virgen de la Victoria, Campus de Teatinos, Málaga, Spain.

COPD 2022 ;19(1):174-181

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Chronic obstructive pulmonary disease (COPD) has been regarded as a disease of smokers, but the prevalence of non-smoking COPD patients have been reported to be considerable. We investigated differences in clinical characteristics between smoking and non-smoking COPD patients. We used data from the Korea COPD Subgroup Study (KOCOSS) database, which is a multicenter cohort that recruits patients from 54 medical centres in Korea. Read More

Ther Adv Chronic Dis 2022 22;13:20406223221084831. Epub 2022 Mar 22.

Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jie Fang Ave., Wuhan 430030, Hubei, China.

Objective: This study aims to describe the imaging features of naïve asthma patients, defined as not receiving corticosteroids or other asthma medications for at least 1 month, and their association with therapeutic response, and to discover novel unbiased imaging phenotypes.

Methods: A total of 109 naïve asthma patients and 50 healthy controls were enrolled in this study. Clinical data and imaging indices of high-resolution computed tomography were collected. Read More

Infect Drug Resist 2022 21;15:1167-1174. Epub 2022 Mar 21.

Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, People's Republic of China.

Objective: To investigate the clinical features of pulmonary nocardiosis (PN) in patients with different underlying diseases.

Methods: Clinical, imaging, treatment and prognosis data from patients diagnosed with PN from July 2011 to June 2021 at the First Affiliated Hospital, Zhejiang University School of Medicine were collected and analyzed. According to different underlying diseases, patients were grouped into immunocompromised host (ICH) group and immunocompetent host (ICO) group, and clinical characteristics were compared between the two groups. Read More

Arch Bronconeumol 2022 Jun 25;58(6):510-512. Epub 2021 Apr 25.

Radiology Department, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC-FMUSP), University of São Paulo, São Paulo, Brazil.

Clin Imaging 2022 Mar 9. Epub 2022 Mar 9.

Division of Cardiothoracic Imaging, Department of Radiology, Columbia University Irving Medical Center, New York, NY, United States of America.

Background: Pneumonitis has been described as a side effect of immunotherapy as well as traditional chemotherapy. Although immune-related adverse event (IRAE) pneumonitis has been extensively characterized, the relationship between IRAE pneumonitis and pneumonitis secondary to chemotherapy is less clear. Here, we present the first analysis of radiographic features of pneumonitis secondary to immunotherapy compared to chemotherapy. Read More

J Rheumatol 2022 Mar 15. Epub 2022 Mar 15.

GM is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (grant number T32 AR055855). JAS is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (grant numbers R01 AR077607, P30 AR070253, and P30 AR072577) and the R. Bruce and Joan M. Mickey Research Scholar Fund. TJD is supported by the National Heart, Lung, and Blood Institute at the National Institutes of Health (NIH; grant nos. K23 HL119558 and R03 HL148484). The funders had no role in the decision to publish or in the preparation of this manuscript. The content is solely the responsibility of the authors and does not necessarily represent the official views of Harvard University, its affiliated academic healthcare centers, or the NIH. G. McDermott, MD, N. Shadick, MD, MPH, P.F. Dellaripa, MD, J.A. Sparks, MD, MMSc, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; R. Gill, MD, Department of Radiology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, Massachusetts; S. Gagne, MD, S. Byrne, MD, Department of Radiology, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; W. Huang, MSPH, X. Wang, MS, L.C. Prisco, BA, A. Zaccardelli, MS, L.W. Martin, BS, L. Masto, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, Massachusetts; V.L. Kronzer, MD, MSCI, Division of Rheumatology, Mayo Clinic, Rochester, Minnesota; T.J. Doyle, MD, MPH, Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA. JAS has received research support from BMS and has performed consultancy for AbbVie, Boehringer Ingelheim, BMS, Gilead, Inova Diagnostics, Janssen, Optum, and Pfizer unrelated to this work. NS reports research support from Mallinckrodt, BMS, Amgen, and Lilly, and has performed consultancy for BMS unrelated to this work. TJD reports grant funding and other support from MBS and Genentech, and personal fees from Boehringer Ingelheim and L.E.K. Consulting unrelated to this study. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. J.A. Sparks, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, Boston, MA 02115, USA. Email: Accepted for publication March 8, 2022.

Objective: To investigate demographic, lifestyle, and serologic risk factors for isolated rheumatoid arthritis (RA)-associated bronchiectasis (RA-BR) that is not a result of interstitial lung disease (ILD).

Methods: We performed a case-control study using patients with RA from the Mass General Brigham Biobank. We reviewed the records of all patients with RA meeting the 2010 American College of Rheumatology/European Alliance of Associations for Rheumatology criteria with computed tomography (CT) chest imaging to identify RA-BR cases and controls with RA and RA-related lung disease. Read More