13,582 results match your criteria Bronchiectasis


Inhaled antibiotics therapy for stable non-cystic fibrosis bronchiectasis: a meta-analysis.

Ther Adv Respir Dis 2020 Jan-Dec;14:1753466620936866

Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital, China Medical University, Shenyang, 110001, China.

Background: The optimum antibiotic therapy for non-cystic fibrosis bronchiectasis (NCFB) has yet to be determined. A meta-analysis was conducted to evaluate the efficacy and safety of inhaled antibiotics in adults with stable NCFB.

Methods: PubMed, EMBASE, MEDLINE and the Cochrane Central Register of Controlled Trials were searched through November 2019. Read More

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http://dx.doi.org/10.1177/1753466620936866DOI Listing

Angiographic Findings and Outcomes of Bronchial Artery Embolization in Patients with Pulmonary Tuberculosis.

Eurasian J Med 2020 Jun 2;52(2):126-131. Epub 2020 Jun 2.

Department of Radiology, Health Sciences University, Tepecik Educational and Research Hospital, Izmir, Turkey.

Objective: We aimed to evaluate the angiographic findings and outcomes of bronchial artery embolization in tuberculosis patients and to compare them with those of non-tuberculosis patients.

Materials And Methods: Patients who underwent bronchial artery embolization in a single interventional radiology department with hemoptysis were reviewed. A total of 89 patients (66 males and 23 females; mean age 52. Read More

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http://dx.doi.org/10.5152/eurasianjmed.2020.19221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311123PMC

[Bronchiectasis - a review].

Laeknabladid 2020 Jul;106(7):352-361

Department of Radiology Karolinska University Hospital Stockholm, Sweden.

Bronchiectasis is a disease that is characterized by permanent bronchial dilation. This can be localized or diffuse in the lungs. The disease can occur at any age and causes cough, sputum production and repeated infections. Read More

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http://dx.doi.org/10.17992/lbl.2020.0708.592DOI Listing

Counting the cost of bronchiectasis.

Respirology 2020 Jun 30. Epub 2020 Jun 30.

Scottish Centre for Respiratory Research, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.

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http://dx.doi.org/10.1111/resp.13888DOI Listing

A predictive model and scoring system combining clinical and CT characteristics for the diagnosis of COVID-19.

Eur Radiol 2020 Jul 1. Epub 2020 Jul 1.

Department of Radiology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, No. 197, Ruijin Er Road, Shanghai, 200025, China.

Objectives: To develop a predictive model and scoring system to enhance the diagnostic efficiency for coronavirus disease 2019 (COVID-19).

Methods: From January 19 to February 6, 2020, 88 confirmed COVID-19 patients presenting with pneumonia and 80 non-COVID-19 patients suffering from pneumonia of other origins were retrospectively enrolled. Clinical data and laboratory results were collected. Read More

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http://dx.doi.org/10.1007/s00330-020-07022-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326621PMC

Etiology of Community-Acquired Pneumonia Requiring Hospital Admission in Adults with and Without Cancers: A Single-Center Retrospective Study in China.

Infect Drug Resist 2020 8;13:1607-1617. Epub 2020 Jun 8.

Department of Pulmonary and Critical Care Medicine, The Second Affiliated Hospital of Air Force Medical University, Xi'an, People's Republic of China.

Background: The etiology and distribution of community-acquired pneumonia (CAP) vary periodically and geographically. The clinical evaluation of CAP among patients with cancers remains unknown.

Patients And Methods: This retrospective hospital-based study on adult CAP was conducted in Tang Du Hospital, China, from September 2018 to August 2019. Read More

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http://dx.doi.org/10.2147/IDR.S251564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294101PMC

Serum Krebs von den Lungen-6 level in the disease progression and treatment of Mycobacterium avium complex lung disease.

Respirology 2020 Jun 29. Epub 2020 Jun 29.

Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.

Background And Objective: The lack of useful biomarkers reflecting the disease state limits the management of Mycobacterium avium complex lung disease (MAC-LD). We clarified the associations between serum KL-6 level, disease progression and treatment response.

Methods: Resected lung tissues from MAC-LD patients were immunostained for KL-6. Read More

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http://dx.doi.org/10.1111/resp.13886DOI Listing

[Non - tuberculous mycobacteriosis of the lungs - diagnostic possibilities in the practice of the pulmonologist].

Ter Arkh 2019 Nov 15;91(11):26-31. Epub 2019 Nov 15.

Central TB Research Institute.

Aim Of The Study: Show the possibilities of diagnosing non - tuberculous mycobacteriosis of the lungs (NTML) in the practice of the pulmonologist.

Materials And Methods: A survey of 90 patients with a confirmed diagnosis of non - tuberculous mycobacteriosis of the lungs (NTML) was presented. The diagnosis of pulmonary mycobacteriosis was established in accordance with the criteria proposed in 2007 by the American Thoracic Society and the American Society of Infectious Diseases (ATS/IDRS). Read More

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http://dx.doi.org/10.26442/00403660.2019.11.000306DOI Listing
November 2019

First Case of Brucella Pneumonia in a Lung Transplant Patient: Case Report and Review of the Literature.

Cureus 2020 Jun 21;12(6):e8733. Epub 2020 Jun 21.

Organ Transplant, King Faisal Specialist Hospital and Research Centre, Riyadh, SAU.

Brucella is one of the most common zoonotic diseases worldwide. It is endemic in the Mediterranean basin. Brucella pneumonia is a rare complication of brucellosis that can present with a variety of clinical and radiological manifestations. Read More

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http://dx.doi.org/10.7759/cureus.8733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308817PMC

Effects of Controlled Voluntary Increase in the Ventilatory Demand on Respiratory System Resistance in Healthy and Non-Cystic Fibrosis Bronchiectasis Subjects: A Cross-Sectional Study.

Arch Bronconeumol 2020 Jun 24. Epub 2020 Jun 24.

Department of Health Sciences, Graduate Program in Functional Performance, Ribeirão Preto Medical School, Ribeirão Preto, São Paulo, Brazil. Electronic address:

Introduction: Bronchiectasis patients may present a reduced functional capacity due to an increase in the ventilatory demand during exercise.

Objective: To evaluate the effects of controlled voluntary hyperinflation and increased respiratory rate on the mechanics of the respiratory system, simulating what happens during exercise, in bronchiectasis and healthy subjects.

Methods: Bronchiectasis (n=30) and healthy (n=16) subjects were evaluated by impulse oscillometry (IOS) during a baseline condition, and in controlled conditions with baseline (b) tidal volume (V) and hyperinflation (H), with respiratory rates at 30(R30) and 40(R40) bpm, in a random order. Read More

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http://dx.doi.org/10.1016/j.arbres.2020.04.008DOI Listing

Does PDT have potential in the treatment of COVID 19 patients?

Photodiagnosis Photodyn Ther 2020 Jun 24:101889. Epub 2020 Jun 24.

The Yorkshire Laser Centre, Goole & District Hospital, Goole, DN14 6RX, UK.

The corona virus pandemic has ignited a proliferation of research aimed at prevention of spread, early diagnosis and treatment. Coincidentally, in recent years the Yorkshire Laser Centre has been engaged in developing the methodology of applying PDT in chronic bronchiectasis. Our methodology is based on Methylene Blue (MB) mediated PDT used topically within the airway. Read More

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http://dx.doi.org/10.1016/j.pdpdt.2020.101889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313506PMC

Radiologic Characteristics of Non-tuberculous Mycobacteria Infection in Patients with Bronchiectasis.

Lung 2020 Jun 26. Epub 2020 Jun 26.

B. Rappaport Faculty of Medicine, Technion- Israel Institute of Technology, Haifa, Israel.

Introduction: Non-tuberculous mycobacteria pulmonary disease (NTM-pd) commonly complicates bronchiectasis. However, clinical and radiological features of NTM-pd and bronchiectasis are very similar. We aimed to develop a radiologic prediction tool for bronchiectasis to identify NTM-pd. Read More

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http://dx.doi.org/10.1007/s00408-020-00371-0DOI Listing

The Remaining Barriers to Normalcy in CF: Advances in Assessment of CF Lung Disease.

Pediatr Pulmonol 2020 Jun 26. Epub 2020 Jun 26.

Division of Pediatric Pulmonology, Allergy, and Sleep Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Despite early diagnosis of cystic fibrosis (CF) through newborn screening, a substantial proportion of infants and young children with CF still demonstrate physiologic and structural evidence of lung disease progression, such as obstructive airway disease and bronchiectasis. The growing availability of highly effective CF transmembrane conductance regulatory modulator therapy to the vast majority of people with CF has led to the potential to alter the natural history of CF lung disease, but in order to assess the full impact of these therapies on CF lung disease and to help guide treatment, sensitive measures of early and mild disease are needed. Chest imaging using computed tomography or magnetic resonance imaging is one approach, but technologic barriers and/or concern about exposure to ionizing radiation may limit its use. Read More

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http://dx.doi.org/10.1002/ppul.24929DOI Listing

Recurrent hypertrophic pulmonary osteoarthropathy in an adult with bronchiectasis.

Respirol Case Rep 2020 Aug 23;8(6):e00602. Epub 2020 Jun 23.

Department of Respiratory Medicine Middlemore Hospital, Counties Manukau DHB Auckland New Zealand.

Hypertrophic pulmonary osteoarthropathy (HPOA) is a well-documented complication of pulmonary malignancy and cystic fibrosis (CF). However, HPOA associated with exacerbations of non-CF bronchiectasis has only been reported once previously in an adolescent. We describe a case of an adult patient with bronchiectasis and HPOA, whose joint symptoms flared during pulmonary exacerbations and improved with treatment of each exacerbation. Read More

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http://dx.doi.org/10.1002/rcr2.602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308669PMC

Meta-analysis of chest CT features of patients with COVID-19 pneumonia.

J Med Virol 2020 Jun 24. Epub 2020 Jun 24.

Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Objectives: To perform a meta-analysis regarding the chest CT manifestations of COVID-19 pneumonia patients.

Methods: PubMed, Embase and Cochrane Library databases were searched from December 1st 2019 until May 1st, 2020 using the keywords of 'COVID-19 virus', 'the 2019 novel coronavirus', 'novel coronavirus' and 'COVID-19'. Studies that evaluated the CT manifestations of common and severe COVID-19 pneumonia were included. Read More

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http://dx.doi.org/10.1002/jmv.26218DOI Listing

Validation of the Korean Version of the Bronchiectasis Health Questionnaire.

Tuberc Respir Dis (Seoul) 2020 Jul 29;83(3):228-233. Epub 2020 Apr 29.

Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Background: The Bronchiectasis Health Questionnaire (BHQ) is a simple and repeatable, self-reporting health status questionnaire for bronchiectasis. We have translated the original version of the BHQ into Korean using a standardized methodology. The purpose of this study was to assess the validity of the Korean version of the BHQ (K-BHQ) with Korean patients. Read More

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http://dx.doi.org/10.4046/trd.2020.0025DOI Listing

[Clinical characteristics of patients with antisynthetase syndrome and interstitial pulmonary disease].

Zhonghua Yi Xue Za Zhi 2020 Jun;100(24):1861-1865

Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital/Institute of Respiratory Medicine, Chinese Academy of Medical Sciences/National Clinical Research Center for Respiratory Diseases, Beijing 100029, China.

To provide reference for clinicians in diagnosis and treatment of antisynthetase syndrome with interstitial pulmonary disease (ASS-ILD) by analyzing the clinical features, imaging features and pulmonary function changes of ASS-ILD patients. A total of 92 patients with ASS-ILD diagnosed in the Respiratory Center of China-Japan Friendship Hospital from January 2015 to May 2018 were included, clinical manifestations, high-resolution computed tomography (HRCT), pulmonary function test, treatment and outcome were retrospectively analyzed. The average age of the 92 patients was (58. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20191120-02521DOI Listing

Clinical features related to hospital expenses for non-cystic fibrosis bronchiectasis in China.

J Int Med Res 2020 Jun;48(6):300060520931616

Department of Respiratory Medicine, Kunming General Hospital of Chengdu Military Command, Kunming, Yunnan, China All authors contributed equally to this paper.

Objective: Bronchiectasis is a common chronic airway disease. We investigated the economic burden and associated factors of bronchiectasis in China.

Methods: In this multicenter retrospective cohort study, we reviewed medical records of patients admitted to 18 tertiary hospitals during 2010 to 2014 with a bronchiectasis-related diagnosis. Read More

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http://dx.doi.org/10.1177/0300060520932116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309388PMC

Alpha-1 Antitrypsin Deficiency and Pulmonary Morbidity in Patients with Primary Immunodeficiency Disease: A Single-Center Experience.

Can Respir J 2020 27;2020:4019608. Epub 2020 May 27.

Department of Medicine A, Hematology, Oncology and Pneumology, University Hospital Muenster, Muenster, Germany.

Background: Alpha-1 antitrypsin deficiency (AATD) is of importance in the pathogenesis of pulmonary emphysema, chronic obstructive pulmonary diseases (COPD), and bronchiectasis. Various pulmonary disorders are a typical feature of primary immunodeficiency disease (PID). This includes recurrent pulmonary infections, immunodysregulation, and autoinflammatory diseases. Read More

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http://dx.doi.org/10.1155/2020/4019608DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273390PMC

Current and future management of non-tuberculous mycobacterial pulmonary disease (NTM-PD) in the UK.

BMJ Open Respir Res 2020 Jun;7(1)

North Central London TB Service, Whittington Health NHS Foundation Trust, London, UK.

A rising number of non-tuberculous mycobacterial (NTM) isolates are being identified in UK clinical practice. There are many uncertainties around the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD), including its epidemiology, diagnosis, treatment and prevention. Regional variations in how patients with NTM-PD are managed reflects the lack of standardised pathways in the UK. Read More

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http://dx.doi.org/10.1136/bmjresp-2020-000591DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311041PMC

"Management of Community-Acquired Pneumonia in Immunocompromised Adults: A Consensus Statement Regarding Initial Strategies".

Chest 2020 Jun 16. Epub 2020 Jun 16.

Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Background: Community-acquired pneumonia (CAP) guidelines have improved the management and outcomes of patients with CAP, primarily by standardization of initial empiric therapy. But current society-published guidelines exclude immunocompromised patients.

Research Question: There is no concensus regarding the initial management of immunocompromised patients with suspected CAP. Read More

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http://dx.doi.org/10.1016/j.chest.2020.05.598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297164PMC
June 2020
7.483 Impact Factor

CT imaging features of COVID-19 pneumonia: initial experience from Turkey.

Diagn Interv Radiol 2020 Jun 19. Epub 2020 Jun 19.

Department of Radiology, Ege University Faculty of Medicine, Izmir, Turkey.

Purpose: We aimed to demonstrate the computed tomography (CT) findings observed at the initial presentation of coronavirus disease 2019 (COVID-19) pneumonia and reveal the most frequent infiltration and distribution patterns of the disease.

Methods: One hundred and eighty-five patients (87 men, 98 women; mean age, 48.7 years), who underwent RT-PCR sampling and high-resolution CT examination in our hospital between March 15, 2020, and April 15, 2020, and got a definitive diagnosis of COVID-19 disease via initial or follow-up RT-PCR test, were included in the study. Read More

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http://dx.doi.org/10.5152/dir.2020.20307DOI Listing

[Allergic bronchopulmonary aspergillosis].

Rev Med Suisse 2020 Jun;16(698):1250-1255

Service de pneumologie, Département de médecine, RHNE site de Pourtalès, 2000 Neuchâtel.

Allergic bronchopulmonary aspergillosis (ABPA) is a specific complex immunological response to the spores of Aspergillus fumigatus (Af) colonizing the bronchi of asthmatic or cystic fibrosis patients. Recurrent episodes of bronchial obstruction and inflammation, as well as mucoid impaction cause bronchiectasis, pulmonary infiltrates and fibrotic alterations of the lung parenchyma, resulting in significant morbidity and mortality. The pathogenesis of ABPA remains incompletely understood, so it is not clear why certain colonized subjects develop hypersensitivity to Af, and why some sensitized patients develop ABPA and others do not. Read More

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Extracorporeal Membrane Oxygenation and Lung Transplantation: Initial Experience at a Single Brazilian Center.

Clinics (Sao Paulo) 2020 30;75:e1698. Epub 2020 Apr 30.

Programa de Transplante Pulmonar, Hospital Israelita Albert Einstein, Sao Paulo, SP, BR.

Objective: To report initial experience from the use of extracorporeal membrane oxygenation (ECMO) in patients who received lung transplantation.

Methods: Retrospective study of a single tertiary center in the Brazilian state of São Paulo, a national reference in lung transplantation, based on the prospective collection of data from electronic medical records. The period analyzed extended from January 2009 (beginning of the program) until December 2018. Read More

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http://dx.doi.org/10.6061/clinics/2020/e1698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196780PMC

Characterization of the severity of dyspnea in patients with bronchiectasis: correlation with clinical, functional, and tomographic aspects.

J Bras Pneumol 2020 15;46(5):e20190162. Epub 2020 Jun 15.

. Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo (SP) Brasil.

Objective: To characterize a population of patients with bronchiectasis, correlating clinical, radiological, and functional aspects with the severity of dyspnea.

Methods: This was a cross-sectional study involving adult patients with HRCT-confirmed bronchiectasis, categorized according to the severity of dyspnea (as being mildly or severely symptomatic, on the basis of the modified Medical Research Council scale). We correlated the severity of dyspnea with clinical parameters, functional parameters (spirometry values, lung volumes, and DLCO), and CT parameters. Read More

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http://dx.doi.org/10.36416/1806-3756/e20190162DOI Listing

The radiological diagnosis of bronchiectasis: what's in a name?

Eur Respir Rev 2020 Jun 17;29(156). Epub 2020 Jun 17.

Dept of Paediatric Pulmonology and Allergology, Erasmus Medical Centre (MC)-Sophia Children's Hospital, Rotterdam, The Netherlands.

Diagnosis of bronchiectasis is usually made using chest computed tomography (CT) scan, the current gold standard method. A bronchiectatic airway can show abnormal widening and thickening of its airway wall. In addition, it can show an irregular wall and lack of tapering, and/or can be visible in the periphery of the lung. Read More

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http://dx.doi.org/10.1183/16000617.0120-2019DOI Listing

CFTR targeted therapies: recent advances in cystic fibrosis and possibilities in other diseases of the airways.

Eur Respir Rev 2020 Jun 16;29(156). Epub 2020 Jun 16.

Dept of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.

Cystic fibrosis transmembrane conductance regulator (CFTR) is an ion transporter that regulates mucus hydration, viscosity and acidity of the airway epithelial surface. Genetic defects in impair regulation of mucus homeostasis, causing severe defects of mucociliary clearance as seen in cystic fibrosis. Recent work has established that CFTR dysfunction can be acquired in chronic obstructive pulmonary disease (COPD) and may also contribute to other diseases that share clinical features of cystic fibrosis, such as asthma, allergic bronchopulmonary aspergillosis and bronchiectasis. Read More

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http://dx.doi.org/10.1183/16000617.0068-2019DOI Listing

Changes in respiratory symptoms during 48 weeks treatment with ARD-3150 (inhaled liposomal ciprofloxacin) in bronchiectasis: results from the ORBIT-3 and -4 studies.

Eur Respir J 2020 Jun 18. Epub 2020 Jun 18.

Aradigm Corporation, Hayward, CA, USA.

Introduction: It is not known if inhaled antibiotics improve respiratory symptoms in patients with bronchiectasis. In the recent phase-3 ORBIT trials, 48-weeks treatment with ARD-3150 (inhaled liposomal ciprofloxacin) did not significantly improve symptoms using the prespecified method of analysis comparing baseline symptoms to those after 48 weeks, when patients had been off treatment for 28 days. This method of analysis does not take account of possible improvements in symptoms while on active treatment. Read More

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http://dx.doi.org/10.1183/13993003.00110-2020DOI Listing

Heterozygous IKKβ Activation Loop Mutation Results in a Complex Immunodeficiency Syndrome.

J Allergy Clin Immunol 2020 Jun 15. Epub 2020 Jun 15.

National Jewish Health, Immunodeficiency Diagnosis and Treatment Program, Department of Pediatrics, 1400 Jackson Street, Denver, CO, 80206, USA.

We identified in an adult with ectodermal dysplasia and immunodeficiency a germline, gain-of-function mutation, K171R, in IKBKB. The K171R mouse immunologic phenotype parallels human, suggesting IKBKB K171R underlies a novel immunodeficiency syndrome. Read More

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http://dx.doi.org/10.1016/j.jaci.2020.06.007DOI Listing

HTLV-I induces lesions in the pulmonary system: A systematic review.

Life Sci 2020 Jun 15;256:117979. Epub 2020 Jun 15.

Center for Tropical Medicine, Federal University of Pará, Belém, PA, Brazil; Center for Biological and Health Sciences, State University of Pará, Belém, PA, Brazil; Evandro Chagas Institute, Ministry of Health, Ananindeua, Belém, PA, Brazil. Electronic address:

This study analyzed the relationship between infection by human T-cell lymphotropic virus type 1 (HTLV-1) and changes in the pulmonary system. Cohort and case-control study models that analyzed a causal association between HTLV-1 and changes in the pulmonary system were considered. There were no restrictions on language and publication period. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117979DOI Listing

Factors associated with long-term haemoptysis recurrence after transarterial embolisation for haemoptysis.

Int J Tuberc Lung Dis 2020 Jun;24(6):606-611

Department of Interventional Radiology, The Third Affiliated Hospital of Soochow University, Changzhou, China.

To assess factors associated with long-term haemoptysis recurrence after transarterial embolisation (TAE) for haemoptysis due to bronchiectasis. Patients with haemoptysis due to bronchiectasis who underwent TAE between May 2010 and May 2019 were included in this retrospective study. Long-term haemoptysis recurrence was defined as the expectoration of >10 mL/day of fresh blood (for at least 1 day) 1 month after TAE. Read More

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http://dx.doi.org/10.5588/ijtld.19.0490DOI Listing

Of tuberculosis and non-tuberculous mycobacterial infections - a comparative analysis of epidemiology, diagnosis and treatment.

J Biomed Sci 2020 Jun 17;27(1):74. Epub 2020 Jun 17.

Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, United States.

Pulmonary diseases due to mycobacteria cause significant morbidity and mortality to human health. In addition to tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), recent epidemiological studies have shown the emergence of non-tuberculous mycobacteria (NTM) species in causing lung diseases in humans. Although more than 170 NTM species are present in various environmental niches, only a handful, primarily Mycobacterium avium complex and M. Read More

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http://dx.doi.org/10.1186/s12929-020-00667-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297667PMC

How does comorbid bronchiectasis affect asthmatic patients? A meta-analysis.

J Asthma 2020 Jun 19:1-13. Epub 2020 Jun 19.

Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Department of Pulmonary and Critical Care Medicine Shanghai, CN 200025 021-34186000.

Objective: Asthma and bronchiectasis are known to be two distinct diseases with different etiology, pathophysiology, management and prognosis. However, a high prevalence of bronchiectasis has been reported in patients with severe asthma. Thus, it is of great importance to identify the impact of bronchiectasis on asthmatic patients. Read More

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http://dx.doi.org/10.1080/02770903.2020.1784194DOI Listing

Age- and sex-related characteristics of the increasing trend of nontuberculous mycobacteria pulmonary disease in a tertiary hospital in South Korea from 2006 to 2016.

Korean J Intern Med 2020 Jun 19. Epub 2020 Jun 19.

Division of Pulmonology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background/aims: The incidence rate of nontuberculous mycobacterial pulmonary disease (NTM-PD) is increasing worldwide. However, data regarding the age- and sex-specific epidemiology of NTM-PD are limited. This study aimed to investigate the long-term epidemiologic trends of NTM-PD within the recent 11- year period in a tertiary referral hospital in Korea. Read More

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http://dx.doi.org/10.3904/kjim.2019.395DOI Listing

Pediatric Patient With Ulcerative Colitis-Associated Bronchiectasis.

ACG Case Rep J 2020 Apr 7;7(4):e00365. Epub 2020 Apr 7.

Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH.

We report a unique case of ulcerative colitis-associated bronchiectasis in a pediatric patient 6 years after colectomy. The patient presented with a chronic cough and had a computed tomography demonstrating bronchiectasis. She was treated with sputum expectoration (airway clearance) via chest physiotherapy and pulse-dose steroids with a prolonged oral taper. Read More

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http://dx.doi.org/10.14309/crj.0000000000000365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224709PMC

Whole exome sequencing identifies compound heterozygous variants of gene in monozygotic twin patients with common variable immunodeficiency.

SAGE Open Med 2020 22;8:2050312120922652. Epub 2020 May 22.

Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.

Objectives: A pair of female Malay monozygotic twins who presented with recurrent upper respiratory tract infections, hepatosplenomegaly, bronchiectasis and bicytopenia were recruited in this study. Both patients were suspected with primary immunodeficiency diseases. However, the definite diagnosis was not clear due to complex disease phenotypes. Read More

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http://dx.doi.org/10.1177/2050312120922652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249565PMC

Changing clinical characteristics of non-cystic fibrosis bronchiectasis in children.

BMC Pulm Med 2020 Jun 16;20(1):172. Epub 2020 Jun 16.

Division of Pediatric Pulmonology, Marmara University, School of Medicine, Istanbul, Turkey.

Background: The prevalence of non-cystic fibrosis (CF) bronchiectasis is increasing in both developed and developing countries in recent years. Although the main features remain similar, etiologies seem to change. Our aim was to evaluate the clinical and laboratory characteristics of our recent non-CF bronchiectasis patients and to compare these with our historical cohort in 2001. Read More

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http://dx.doi.org/10.1186/s12890-020-01214-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298950PMC

The impact of adjuvant surgical treatment of nontuberculous mycobacterial pulmonary disease on prognosis and outcome.

Respir Res 2020 Jun 16;21(1):153. Epub 2020 Jun 16.

Department of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center, 5-1-1 Toneyama Toyonaka, Osaka, Japan.

Background: Lung resection in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) has been reported to be associated with favorable outcomes. However, little is known regarding the risk and prognostic factors for refractory and recurrent cases. We aimed to evaluate the overall impact and benefit of adjuvant lung surgery by comparing NTM-PD patients who underwent adjuvant lung resection with those treated exclusively with antibiotics. Read More

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http://dx.doi.org/10.1186/s12931-020-01420-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298848PMC

Anxiety and depression in bronchiectasis: Response to pulmonary rehabilitation and minimal clinically important difference of the Hospital Anxiety and Depression Scale.

Chron Respir Dis 2020 Jan-Dec;17:1479973120933292

Harefield Respiratory Research Group, Royal Brompton and Harefield NHS Foundation Trust, Harefield, UK.

The aims of the study were to evaluate the responsiveness of Hospital Anxiety and Depression Scale-Anxiety (HADS-A) subscale and HADS-Depression (HADS-D) subscale to pulmonary rehabilitation (PR) in patients with bronchiectasis compared to a matched group of patients with chronic obstructive pulmonary disease (COPD) and provide estimates of the minimal clinically important difference (MCID) of HADS-A and HADS-D in bronchiectasis. Patients with bronchiectasis and at least mild anxiety or depression (HADS-A ≥ 8 or/and HADS-D ≥ 8), as well as a propensity score-matched control group of patients with COPD, underwent an 8-week outpatient PR programme (two supervised sessions per week). Within- and between-group changes were calculated in response to PR. Read More

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http://dx.doi.org/10.1177/1479973120933292DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301664PMC

Risk Factor Evaluation for Methicillin-Resistant and in Community-Acquired Pneumonia.

Authors:
Paul O Lewis

Ann Pharmacother 2020 Jun 16:1060028020935106. Epub 2020 Jun 16.

Johnson City Medical Center, Johnson City, TN, USA.

The 2019 community-acquired pneumonia guidelines recommend using recent respiratory cultures and locally validated epidemiology plus risk factor assessment to determine empirical coverage of methicillin-resistant (MRSA) and . To develop a methodology for evaluating local epidemiology and validating local risk factors for and MRSA. This multicenter, retrospective cohort evaluated adult patients admitted for pneumonia. Read More

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http://dx.doi.org/10.1177/1060028020935106DOI Listing

Impact at school age of early chronic methicillin-sensitive Staphylococcus aureus infection in children with cystic fibrosis.

Pediatr Pulmonol 2020 Jun 16. Epub 2020 Jun 16.

Bordeaux University Hospital, Pellegrin-Enfants Hospital, Pediatric CF-Center (CRCM), Clinical Investigation Centre (CIC 1401), Imaging Department, Bordeaux, France.

Background: Bacterial infection early in life may increase structural lung lesions in children with cystic fibrosis (CF).

Methods: A 9-year monocentric (Bordeaux University Hospital, France) retrospective study in children with CF to evaluate the impact of the early onset (at one year of age, Y1) of chronic Meticillin-Sensitive Staphylococcus aureus (MSSA) infection on the severity of bronchiectasis and Bhalla score on CT-scan, clinical status, lung function tests, and serum IgG at the age of six years (Y6).

Results: 37 children were included: 10 had contracted chronic MSSA infection at Y1 and 27 at a later date. Read More

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http://dx.doi.org/10.1002/ppul.24906DOI Listing

Consensus Document on the Diagnosis and Treatment of Chronic Bronchial Infection in Chronic Obstructive Pulmonary Disease.

Arch Bronconeumol 2020 Jun 12. Epub 2020 Jun 12.

Servicio de Neumología, Hospital Universitari i Politècnic La Fe, Valencia, España.

Although the chronic presence of microorganisms in the airways of patients with stable chronic obstructive pulmonary disease (COPD) confers a poor outcome, no recommendations have been established in disease management guidelines on how to diagnose and treat these cases. In order to guide professionals, the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) has prepared a document which aims to answer questions on the clinical management of COPD patients in whom microorganisms are occasionally or habitually isolated. Since the available scientific evidence is too heterogeneous to use in the creation of a clinical practice guideline, we have drawn up a document based on existing scientific literature and clinical experience, addressing the definition of different clinical situations and their diagnosis and management. Read More

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http://dx.doi.org/10.1016/j.arbres.2020.04.023DOI Listing

The fungal airway microbiome in cystic fibrosis and non-cystic fibrosis bronchiectasis.

J Cyst Fibros 2020 Jun 13. Epub 2020 Jun 13.

National Heart and Lung Institute, Imperial College, London SW3 6LY, UK.

Background: The prevalence of fungal disease in cystic fibrosis (CF) and non-CF bronchiectasis is increasing and the clinical spectrum is widening. Poor sensitivity and a lack of standard diagnostic criteria renders interpretation of culture results challenging. In order to develop effective management strategies, a more accurate and comprehensive understanding of the airways fungal microbiome is required. Read More

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http://dx.doi.org/10.1016/j.jcf.2020.05.013DOI Listing

Characterization of clinical and genetic spectrum of Chinese patients with cystic fibrosis.

Orphanet J Rare Dis 2020 Jun 15;15(1):150. Epub 2020 Jun 15.

McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100005, China.

Background: Cystic fibrosis (CF) is a rare autosomal recessive disorder caused by biallelic mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The clinical features and mutation spectrum of CF have been well characterized in Caucasians, while limited studies were conducted in Chinese patients.

Subjects And Methods: A total of 20 individuals from 19 families were diagnosed with CF in this study. Read More

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http://dx.doi.org/10.1186/s13023-020-01393-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294671PMC

Real-life experience with high-frequency chest wall oscillation vest therapy in adults with non-cystic fibrosis bronchiectasis.

Ther Adv Respir Dis 2020 Jan-Dec;14:1753466620932508

RespirTech, A Philips Company, St. Paul, MN, USA.

Background: High frequency chest wall oscillation (HFCWO) has long been used for airway clearance for patients with cystic fibrosis. Only limited research has evaluated this therapy in adult patients with non-cystic fibrosis bronchiectasis (NCFB).

Methods: Data from 2596 patients from a registry of adult bronchiectasis patients using HFCWO therapy was used to evaluate hospitalization patterns before and after initiation of HFCWO therapy, as well as antibiotic use and self-reported metrics of quality of life. Read More

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http://dx.doi.org/10.1177/1753466620932508DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297124PMC

Recognizing genetic disease: A key aspect of pediatric pulmonary care.

Pediatr Pulmonol 2020 Jul;55(7):1794-1809

Pulmonary Division, Massachusetts General Hospital for Children, Boston, Massachusetts.

Advancement in technology has improved recognition of genetic etiologies of disease, which has impacted diagnosis and management of rare disease patients in the pediatric pulmonary clinic. This review provides an overview of genetic conditions that are likely to present with pulmonary features and require extensive care by the pediatric pulmonologist. Increased familiarity with these conditions allows for improved care of these patients by reducing time to diagnosis, tailoring management, and prompting further investigation into these disorders. Read More

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http://dx.doi.org/10.1002/ppul.24706DOI Listing

Visuomotor reaction time and dynamic balance in children with cystic fibrosis and non-cystic fibrosis bronchiectasis: A case-control study.

Pediatr Pulmonol 2020 Jun 13. Epub 2020 Jun 13.

Faculty of Medicine, Department of Pediatric Chest Diseases, Hacettepe University, Ankara, Turkey.

Objective: Extrapulmonary involvement such as balance and reaction time is unclear in cystic fibrosis (CF) patients. The aim of this study was to evaluate visuomotor reaction time (VMRT) and dynamic balance in children with CF and non-CF bronchiectasis compared to healthy children.

Design/methods: Demographic and clinical characteristics were recorded. Read More

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http://dx.doi.org/10.1002/ppul.24903DOI Listing

Tracking of Infused Mesenchymal Stem Cells in Injured Pulmonary Tissue in -Deficient Mice.

Cells 2020 Jun 10;9(6). Epub 2020 Jun 10.

Division for Allergy, Pneumology and Cystic Fibrosis, Department for Children and Adolescents, University Hospital, Goethe-University, 60596 Frankfurt am Main, Germany.

Pulmonary failure is the main cause of morbidity and mortality in the human chromosomal instability syndrome Ataxia-telangiectasia (A-T). Major phenotypes include recurrent respiratory tract infections and bronchiectasis, aspiration, respiratory muscle abnormalities, interstitial lung disease, and pulmonary fibrosis. At present, no effective pulmonary therapy for A-T exists. Read More

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http://dx.doi.org/10.3390/cells9061444DOI Listing