14,225 results match your criteria Bronchiectasis


3 Tesla MRI in diagnosis and follow up of children with pneumonia.

Clin Imaging 2021 Jun 1;79:213-218. Epub 2021 Jun 1.

Ondokuz Mayis University Faculty of Medicine, Department of Biostatistics and Medical Informatics, Samsun, Turkey.

Purpose: To investigate the utilization of 3-Tesla (3 T) magnetic resonance imaging (MRI) in detection of pulmonary abnormalities in children with pneumonia.

Materials And Methods: Forty-seven children with pneumonia prospectively underwent 3 T thoracic MRI and posteroanterior (PA) chest radiography (CR). Of these, 15 patients also underwent contrast-enhanced thorax computed tomography (CT) or high-resolution CT (HRCT). Read More

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Feasibility of shortening intravenous antibiotic therapy based on bacterial load- a proof of concept randomised controlled trial.

Eur Respir J 2021 Jun 10. Epub 2021 Jun 10.

MRC Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh, UK.

Introduction: There is lack of evidence to guide duration of intravenous antibiotics for bronchiectasis exacerbations.

Aims: To assess whether it is feasible based on bacterial load to shorten intravenous antibiotics during exacerbations and whether 14 days treatment is superior.

Method: We recruited participants requiring intravenous antibiotics for exacerbations. Read More

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Excessive Mucous Production in COPD Patients is Similar Regardless of the Presence of Bronchiectasis in the COPDGene Cohort.

Chronic Obstr Pulm Dis 2021 Jun 10. Epub 2021 Jun 10.

HealthPartners Institute, Bloomington, Minnesota, United States.

Purpose: To assess whether the presence or absence of bronchiectasis has an impact on the patient reported symptoms of COPD patients.

Methods: The study included subjects from the COPDGene Cohort with available high resolution chest tomography (HRCT) reporting the presence or absence of bronchiectasis (BE+/BE-) and survey data reporting the presence or absence of chronic bronchitis symptoms (CB+/CB-). Patient symptoms based on the St. Read More

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Pulmonary Hypertension in Patients with Common Variable Immunodeficiency.

J Clin Immunol 2021 Jun 10. Epub 2021 Jun 10.

Assistance Publique - Hôpitaux de Paris (AP-HP), Department of Respiratory and Intensive Care Medicine, Pulmonary Hypertension National Referral Center, Hôpital Bicêtre, Le Kremlin-Bicêtre, France.

Purpose: Common variable immunodeficiency (CVID) is known to cause infectious, inflammatory, and autoimmune manifestations. Pulmonary hypertension (PH) is an unusual complication of CVID with largely unknown characteristics and mechanisms.

Methods: We report the clinical, functional, hemodynamics, radiologic and histologic characteristics, and outcomes of CVID-associated PH patients from the French PH Network. Read More

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A review of physiotherapy practice for people with bronchiectasis.

ERJ Open Res 2021 Apr 7;7(2). Epub 2021 Jun 7.

Cabrini Health, Malvern, Australia.

https://bit.ly/2U3c99H. Read More

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Anxiety and depression as possible criteria in the treatment of bronchiectasis.

Turk Gogus Kalp Damar Cerrahisi Derg 2021 Apr 26;29(2):233-238. Epub 2021 Apr 26.

Department of Thoracic Surgery, Akdeniz University Faculty of Medicine, Antalya, Turkey.

Background: The aim of this study was to investigate the effect of bronchiectasis operation on anxiety and depression.

Methods: Between August 2014 and March 2019, a total of 167 patients with bronchiectasis (107 males, 60 females; mean age: 43.5±13. Read More

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Mepolizumab effectiveness in patients with severe eosinophilic asthma and co-presence of bronchiectasis: A real-world retrospective pilot study.

Respir Med 2021 Jun 1;185:106491. Epub 2021 Jun 1.

Respiratory Medicine Unit, "Policlinico-Vittorio Emanuele San Marco" University Hospital, Via S. Sofia, 78, 95123, Catania, Italy; Department of Clinical and Experimental Medicine, Section of Respiratory Medicine, University of Catania, Via Santa Sofia 78, 95123, Catania, Italy. Electronic address:

Background: The association of bronchiectasis (BE) in patients with severe eosinophilic asthma (SEA) is quite frequent. Mepolizumab is a well-recognized treatment for SEA; we aim to evaluate its effectiveness in SEA patients with and without BE in real-life.

Methods: We performed a single-center retrospective pilot study, including patients with SEA treated with mepolizumab for one year. Read More

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Post- infectious bronchiolitis obliterans in children: Clinical and radiological evaluation and long- term results.

Heart Lung 2021 Jun 4;50(5):660-666. Epub 2021 Jun 4.

Division of Pediatric Pulmonology, Faculty of Medicine, Bezmialem Vakif University, İstanbul, Turkey.

Background And Objective: This study aims to evaluate clinical and radiological findings and treatment outcomes of the patients with PIBO.

Methods: One hundred fourteen children were enrolled. Initial demographic and clinical findings were evaluated. Read More

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Pulmonary Biofilm-Based Chronic Infections and Inhaled Treatment Strategies.

Int J Pharm 2021 Jun 2:120768. Epub 2021 Jun 2.

Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, Texas, 78712, USA. Electronic address:

Certain pulmonary diseases, such as cystic fibrosis (CF), non-CF bronchiectasis, chronic obstructive pulmonary disease, and ventilator-associated pneumonia, are usually accompanied by respiratory tract infections due to the physiological alteration of the lung immunological defenses. Recurrent infections may lead to chronic infection through the formation of biofilms. Chronic biofilm-based infections are challenging to treat using antimicrobial agents. Read More

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Home-based pulmonary rehabilitation in people with bronchiectasis: a randomised controlled trial.

ERJ Open Res 2021 Apr 31;7(2). Epub 2021 May 31.

Postgraduate Program in Rehabilitation Sciences, Universidade Nove de Julho, Sao Paulo-SP, Brazil.

Aim: To investigate the short- and long-term effects of home-based pulmonary rehabilitation (HBPR) on functional capacity, quality of life, peripheral muscle strength, dyspnoea and daily physical activity in people with bronchiectasis.

Methods: Randomised controlled trial with 63 participants with bronchiectasis. The HBPR group performed three sessions per week for 8 weeks (aerobic exercise: step training for 20 min; resistance training: exercises for quadriceps, hamstrings, deltoids and biceps brachii using elastic bands). Read More

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pneumonia with bronchiectasis required prolonged voriconazole treatment.

Respirol Case Rep 2021 Jun 25;9(6):e00783. Epub 2021 May 25.

Department of Respiratory Medicine Toho University Omori Medical Center Tokyo Japan.

is a black fungus that rarely causes respiratory infection. We report a case of . pneumonia with bronchiectasis that relapsed after 11 months of voriconazole (VRCZ) treatment in a rheumatoid arthritis (RA) patient with bronchiectasis. Read More

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Multiple nodular opacities only involving the right middle pulmonary lobe: Unusual manifestation of tuberculosis.

Clin Case Rep 2021 May 1;9(5):e04086. Epub 2021 Apr 1.

Department of Respiratory Medicine Koseiren Takaoka Hospital Takaoka Japan.

Bronchoscopy should be actively performed to differentiate pulmonary tuberculosis in patients with lesions in the middle lobe, which are unaccompanied by bronchiectasis or present without obvious lesions in other lobes. Read More

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Contribution of F-FDG PET/CT in the Differential Diagnosis of Pulmonary Hamartomas and Pulmonary Carcinoids

Mol Imaging Radionucl Ther 2021 06;30(2):101-106

University of Health Sciences Turkey, Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Clinic of Pathology, Ankara, Turkey

Objectives: This study aimed to evaluate fluorine-fluorodeoxyglucose (F-FDG) positron emission tomography/computed tomography (PET/CT) findings in the differential diagnosis of pulmonary carcinoids and pulmonary hamartomas.

Methods: F-FDG PET/CT findings of 34 patients with pulmonary carcinoids (12 atypical, 22 typical) and 32 patients with pulmonary hamartomas were retrospectively evaluated. Both mean diameter and mean maximum standardized uptake value (SUV) of hamartomas and carcinoids were compared by Mann-Whitney U and Kruskall-Wallis H tests. Read More

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New Perspectives in the Diagnosis and Management of Allergic Fungal Airway Disease.

J Asthma Allergy 2021 25;14:557-573. Epub 2021 May 25.

Institute for Lung Health, Department of Respiratory Sciences, College of Life Sciences, University of Leicester, and Allergy and Respiratory Medicine Service, NIHR Biomedical Research Centre: Respiratory, University Hospitals of Leicester NHS Trust, Leicester, UK.

Allergy to airway-colonising, thermotolerant, filamentous fungi represents a distinct eosinophilic endotype of often severe lung disease. This endotype, which particularly affects adult asthma, but also complicates other airway diseases and sometimes occurs de novo, has a heterogeneous presentation ranging from severe eosinophilic asthma to lobar collapse. Its hallmark is lung damage, characterised by fixed airflow obstruction (FAO), bronchiectasis and lung fibrosis. Read More

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Best Practices: Imaging Strategies for Reduced-Dose Chest CT in the Management of Cystic Fibrosis-Related Lung Disease.

AJR Am J Roentgenol 2021 Jun 2:1-10. Epub 2021 Jun 2.

Department of Radiology, Cork University Hospital, Wilton, Cork T12 DC4A, Ireland.

Cystic fibrosis (CF) is a multisystemic life-limiting disorder. The leading cause of morbidity in CF is chronic pulmonary disease. Chest CT is the reference standard for detection of bronchiectasis. Read More

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Increased Incidence and Associated Risk Factors of Aspergillosis in Patients with Bronchiectasis.

J Pers Med 2021 May 17;11(5). Epub 2021 May 17.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul 07441, Korea.

There are insufficient data regarding the relationship between non-cystic fibrosis bronchiectasis and incident aspergillosis. We performed a population-based, matched cohort study using data from the Korean National Health Insurance database between 2003 and 2013. The incidence of aspergillosis was 50/100,000 person-years in the bronchiectasis cohort and 11/100,000 person-years in the matched cohort (subdistribution hazard ratio, 4. Read More

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Proteases, Mucus, and Mucosal Immunity in Chronic Lung Disease.

Int J Mol Sci 2021 May 9;22(9). Epub 2021 May 9.

Airway Innate Immunity Research (AiiR) Group, Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast BT9 7BL, UK.

Dysregulated protease activity has long been implicated in the pathogenesis of chronic lung diseases and especially in conditions that display mucus obstruction, such as chronic obstructive pulmonary disease, cystic fibrosis, and non-cystic fibrosis bronchiectasis. However, our appreciation of the roles of proteases in various aspects of such diseases continues to grow. Patients with muco-obstructive lung disease experience progressive spirals of inflammation, mucostasis, airway infection and lung function decline. Read More

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The Role of Hydrogen Sulfide in Respiratory Diseases.

Biomolecules 2021 May 1;11(5). Epub 2021 May 1.

Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng 475004, China.

Respiratory diseases are leading causes of death and disability around the globe, with a diverse range of health problems. Treatment of respiratory diseases and infections has been verified to be thought-provoking because of the increasing incidence and mortality rate. Hydrogen sulfide (HS) is one of the recognized gaseous transmitters involved in an extensive range of cellular functions, and physiological and pathological processes in a variety of diseases, including respiratory diseases. Read More

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Effectiveness of low-dose intravenous immunoglobulin therapy in minor primary antibody deficiencies: a two-year real-life experience.

Clin Exp Immunol 2021 Jun 1. Epub 2021 Jun 1.

Immunoallergology Unit, Careggi University Hospital, Florence, Italy.

Primary Antibody Deficiencies (PAD) are the most prevalent group of Primary Immunodeficiencies (PID) in adults and Immunoglobulin Replacement Therapy (IRT) is the mainstay therapy to improve clinical outcomes. IRT is, however, expensive and, in minor PAD, clear recommendations about IRT are lacking. We conducted a retrospective real-life study to assess the effectiveness of low-dose IRT in minor PAD on 143 patients fulfilling European Society for Immunodeficiencies (ESID) diagnostic criteria for IgG subclass deficiency (IgGSD) or Unclassified Antibody Deficiency (UAD). Read More

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Automated antimicrobial susceptibility testing of slow-growing Pseudomonas aeruginosa strains in the presence of tetrazolium salt WST-1.

J Microbiol Methods 2021 Jul 27;186:106252. Epub 2021 May 27.

bioMérieux, La Balme-les-Grottes, France. Electronic address:

Slow growing, mucoid isolates of Pseudomonas aeruginosa require adaptation of the protocol used for automated antimicrobial susceptibility testing (AST). In the present study we used a water soluble tetrazolium salt WST-1 (4-[3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate) in combination with menadione for possibly improving AST of slow growing and biofilm-forming P. aeruginosa isolates from cystic fibrosis (CF) patients. Read More

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Novel STAT3 gain-of-function variant with hypogammaglobulinemia and recurrent infection phenotype.

Clin Exp Immunol 2021 May 29. Epub 2021 May 29.

Primary Immunodeficiency Clinical Unit and Laboratory, Department of Dermatology, Venereology and Dermatooncology, Semmelweis University, Budapest, Hungary.

Signal transducer and activator of transcription 3 (STAT3) gain-of-function (GOF) syndrome is an early-onset monogenic inborn error of immunity characterized by multi-organ autoimmune disorders, growth failure and lymphoproliferation. We describe that STAT3 GOF syndrome may be presented with hypogammaglobulinemia and recurrent severe upper and lower respiratory tract infections. In addition, the patient had lymphoproliferation, short stature and interstitial lung disease. Read More

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Nontuberculous mycobacterial pulmonary disease and associated risk factors in China: A prospective surveillance study.

J Infect 2021 May 25. Epub 2021 May 25.

Department of Clinical Laboratory, Henan Provincial Infectious Diseases Hospital, Zhengzhou, China.

Background: We aimed to address the knowledge gap that exists regarding the epidemiological, demographic, and clinical characteristics of nontuberculous mycobacterial pulmonary diseases (NTM-PDs) among smear-positive patients with symptoms suggestive of pulmonary tuberculosis (PTB) in China.

Methods: Prospective and national surveillance of NTM-PD was performed from 17 hospitals within the China Nontuberculous Mycobacteria Surveillance Study (CNTMS). Patients were eligible for inclusion if they had positive smears during hospitalization. Read More

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Allergic Broncho-Pulmonary Aspergillosis.

Pediatr Ann 2021 May 1;50(5):e214-e221. Epub 2021 May 1.

Allergic broncho-pulmonary aspergillosis (ABPA) is an immunologically mediated lung disease that usually occurs in people with a diagnosis of asthma or cystic fibrosis. It is a noninvasive lung disease caused by colonization of the airways with . In people who are susceptible, leads to an exaggerated immune response and ultimately pulmonary inflammation and lung damage. Read More

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Bronchial Brushing and Diagnosis of Pulmonary Nontuberculous Mycobacteria Infection.

Respiration 2021 May 27:1-9. Epub 2021 May 27.

Department of Respiratory Medicine, Toho University Omori Medical Center, Tokyo, Japan.

Background: The optimal bronchoscopy procedure for diagnosis of pulmonary nontuberculous mycobacteria (NTM) infection is unclear.

Objective: This study investigated the usefulness of bronchial brushing in bronchoscopy for diagnosis of pulmonary NTM infection in patients with suspected NTM lung disease and nodular bronchiectasis on chest computed tomography (CT) images.

Methods: Bronchoscopy was prospectively performed for 69 patients with clinically suspected pulmonary NTM infection on chest CT from December 2017 through December 2019. Read More

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Allergic fungal airways disease (AFAD): an under-recognised asthma endotype.

Mycopathologia 2021 May 27. Epub 2021 May 27.

Department of Respiratory Sciences, Institute for Lung Health, University of Leicester, University Road, Leicester, LE1 7RH, UK.

The term allergic fungal airways disease has a liberal definition based on IgE sensitisation to thermotolerant fungi and evidence of fungal-related lung damage. It arose from a body of work looking into the role of fungi in asthma. Historically fungi were considered a rare complication of asthma, exemplified by allergic bronchopulmonary aspergillosis; however, there is a significant proportion of individuals with Aspergillus fumigatus sensitisation who do not meet these criteria, who are at high risk for the development of lung damage. Read More

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Nonsurgical management of dynamic pneumatocele via endobronchial administration of fibrin sealant.

Pediatr Pulmonol 2021 May 25. Epub 2021 May 25.

Division of Pulmonary Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.

A 12-year-old male was admitted to the Medical Intensive Care Unit for respiratory failure requiring temporary tracheostomy secondary to an extensive necrotizing methicillin-resistant Staphylococcus aureus pneumonia. Imaging revealed destructive bronchiectasis and multifocal lung abscesses, more advanced in the right lung. He was discharged home after 42-day hospital admission. Read More

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Serum albumin is a predictor of respiratory hospitalization in patients with bronchiectasis.

Chron Respir Dis 2021 Jan-Dec;18:14799731211017548

Division of Pulmonology and Allergy, Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Republic of Korea.

We evaluated serum albumin as an index for predicting respiratory hospitalization in patients with bronchiectasis. We retrospectively reviewed the medical records of 177 patients with bronchiectasis, categorized them into low and normal albumin groups, and compared their clinical characteristics. The prediction of respiratory hospitalization by factors such as serum albumin level, bronchiectasis severity index (BSI), and FACED score (an acronym derived from five variables of forced expiratory volume in 1 s; FEV, age, chronic colonization of , extent of bronchiectasis, and dyspnea) was assessed. Read More

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Interesting case of allergic broncho pulmonary aspergillosis (ABPA) with high-attenuation mucus (HAM).

BMJ Case Rep 2021 May 24;14(5). Epub 2021 May 24.

Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

A 25-year-old man, who was taking treatment for his poorly controlled asthma, presented with symptoms of cough with expectoration, gradually progressive shortness of breath, fever on and off and diffuse wheeze for 2 years. Chest X-ray revealed hyperinflation of lung field with dense opacification at right upper lobe. High-resolution CT chest showed bilateral patchy consolidation, central bronchiectasis and high-attenuation mucus (HAM) impaction. Read More

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Pseudomonas aeruginosa infection, but not mono or dual-combination CFTR modulator therapy affects circulating regulatory T cells in an adult population with cystic fibrosis.

J Cyst Fibros 2021 May 21. Epub 2021 May 21.

Department of Pulmonary Medicine, University Hospital Essen- Ruhrlandklinik, Essen, Germany.

Background: Chronic infection and an exaggerated inflammatory response are key drivers of the pathogenesis of cystic fibrosis (CF), especially CF lung disease. An imbalance of pro- and anti-inflammatory mediators, including dysregulated Th2/Th17 cells and impairment of regulatory T cells (Tregs), maintain CF inflammation. CF transmembrane conductance regulator (CFTR) modulator therapy might influence these immune cell abnormalities. Read More

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