12,797 results match your criteria Bronchiectasis


Bronchiectasis phenotypes.

Curr Opin Pulm Med 2019 Mar 18. Epub 2019 Mar 18.

Pneumology Department, Hospital Universitari Vall d' Hebron (HUVH), Institut de Recerca Vall d'Hebron (VHIR), Barcelona, Spain.

Purpose Of Review: Bronchiectasis is a chronic respiratory disease with heterogeneous clinical manifestations and outcomes. Identifying clinical phenotypes could help in managing bronchiectasis patients and hopefully improve disease prognosis by adopting personalized treatment. We review the current literature on clinical phenotypes of bronchiectasis and try to highlight priorities for future research. Read More

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http://dx.doi.org/10.1097/MCP.0000000000000569DOI Listing

Severe uncontrolled asthma with bronchiectasis: a pilot study of an emerging phenotype that responds to mepolizumab.

J Asthma Allergy 2019 5;12:83-90. Epub 2019 Mar 5.

Department of Medical and Surgical Sciences, Institute of Respiratory Diseases, University of Foggia, Foggia, Italy,

Background: Asthma and bronchiectasis are different conditions that frequently coexist. The prevalence of bronchiectasis rises considerably in subjects with severe asthma (25%-51%).

Objective: We evaluated the clinical and biological efficacy of mepolizumab on our pilot population of severe uncontrolled asthmatics with bronchiectasis not related to other pathologies. Read More

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http://dx.doi.org/10.2147/JAA.S196200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407514PMC

Spectrum of pulmonary aspergillosis in Hyper IgE syndrome with autosomal dominant STAT3 deficiency.

J Allergy Clin Immunol Pract 2019 Mar 13. Epub 2019 Mar 13.

Service de Maladies Infectieuses et Tropicales, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris (APHP), Université Paris Descartes, Paris, France; Institut Pasteur, CNRS, Centre National de Référence Mycoses Invasives et Antifongiques, Unité de Mycologie Moléculaire, UMR 2000, Paris,France. Electronic address:

Background: Autosomal dominant signal transducer and activator of transcription 3 (STAT3) deficiency predisposes to recurrent bacterial pneumonia, complicated by bronchiectasis and cavitations. Aspergillosis is a major cause of morbidity in these patients. However, its diagnosis, classification, and treatment are challenging. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.02.041DOI Listing

A systematic review of pharmacotherapeutic clinical trial end-points for bronchiectasis in adults.

Eur Respir Rev 2019 Mar 14;28(151). Epub 2019 Mar 14.

School of Medicine, University of Dundee, Dundee, UK

Bronchiectasis is an increasing clinical problem, but multiple recent clinical trials have failed to reach their primary end-point. Difficulties in achieving "positive" bronchiectasis trials is reflected in a lack of agreement from trialists and regulators on what are the optimal end-points.To evaluate the use of end-points in bronchiectasis trials, we conducted a systematic review of published bronchiectasis trials from 2008 to 2018 and extracted end-points used, definitions, methods of analysis and responsiveness. Read More

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http://err.ersjournals.com/lookup/doi/10.1183/16000617.0108-
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http://dx.doi.org/10.1183/16000617.0108-2018DOI Listing
March 2019
5 Reads

[Bullous pneumonia secondary to Elizabethkingia meningoseptica, its clinical and radiological evolution].

Arch Argent Pediatr 2019 Apr;117(2):e150-e154

Servicio de Neumonología, Hospital de Pediatría "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires, Argentina.

Elizabethkingia meningoseptica is an opportunistic pathogen with a high mortality and an increasing incidence in the intensive care units. We present a 4-year-old patient with a history of atresia of the biliary tract and a liver transplant at 11 months of age, who was admitted for acute respiratory infection with hypoxemia. During the hospitalization, she required mechanical ventilation. Read More

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http://dx.doi.org/10.5546/aap.2019.e150DOI Listing
April 2019
1 Read

Comparison of clinical characteristics of patients with Mycobacterium avium complex disease by gender.

Epidemiol Infect 2019 Jan;147:e108

The First Department of Internal Medicine,Shinshu University School of Medicine,Matsumoto, Nagano,Japan.

The clinical characteristics of male patients with pulmonary Mycobacterium avium complex disease have not been clearly defined. We aimed to clarify the clinical characteristics of male patients with pulmonary Mycobacterium avium complex disease compared with female patients.We retrospectively reviewed the medical records of patients with pulmonary Mycobacterium avium complex disease who visited the outpatient clinic of the Shinshu University Hospital between 2003 and 2016 and compared the clinical characteristics of male and female patients. Read More

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http://dx.doi.org/10.1017/S0950268819000293DOI Listing
January 2019
1 Read

Investigating the role of circulating CXCR5-expressing CD8+ T-cells as a biomarker for bacterial infection in subjects with pneumonia.

Respir Res 2019 Mar 12;20(1):54. Epub 2019 Mar 12.

Clinical Immunology Laboratory, the First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, China.

Background: Recently, lymphoid follicle-confined and circulating CD8+ T-cells expressing the C-X-C chemokine receptor type 5 (CXCR5) were described, which was involved in anti-virus immune response. However, the dynamics and role of circulating CXCR5-expressing CD8+ T-cells during bacterial infection is unknown. So, we asked whether CXCR5+ CD8+ T cells were also generated during bacterial infections in lower respiratory tract. Read More

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http://dx.doi.org/10.1186/s12931-019-1011-4DOI Listing
March 2019
1 Read

Quantitative and semi-quantitative computed tomography analysis of interstitial lung disease associated with systemic sclerosis: A longitudinal evaluation of pulmonary parenchyma and vessels.

PLoS One 2019 12;14(3):e0213444. Epub 2019 Mar 12.

Institute of Radiology, Pole of Imaging, Laboratory and Infectivology Sciences, Diagnostic Imaging Area, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.

Objectives: To evaluate interstitial lung disease associated with systemic sclerosis (SSc-ILD) and its changes during treatment by using quantitative analysis (QA) compared to semi-quantitative analysis (semiQA) of chest computed tomography (CT) scans. To assess the prognostic value of QA in predicting functional changes.

Materials And Methods: We retrospectively selected 35 consecutive patients with SSc-ILD with complete pulmonary functional evaluation, Doppler-echocardiography, immunological tests, and chest CT scan at both baseline and follow-up after immunosuppressive therapy. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0213444PLOS
March 2019
1 Read

Common alternative diagnoses among a pediatric hospital-based cohort evaluated for tuberculosis in Karachi, Pakistan: The need for facilitated referral in tuberculosis clinics.

Int J Mycobacteriol 2019 Jan-Mar;8(1):42-47

Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, Pakistan; Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London WCIE 7HT, England, UK.

Background: Children evaluated for tuberculosis (TB) are often diagnosed with miscellaneous conditions that mimic TB. Knowledge of differentials informs policy on service provision through liaison with referral centers offering definitive diagnosis and treatment for common alternative disorders.

Methods: We reviewed medical records of children who were offered diagnostic testing for TB (culture or Xpert MTB/RIF) at a tertiary care hospital in Karachi, Pakistan to identify common alternative diagnoses among children who are evaluated for TB. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_8_19DOI Listing
March 2019
1 Read

[Azithromycine and chronic bronchial diseases: For which patients? For which benefits? With what modalities?]

Authors:
P Pronost C Tromeur

Rev Med Interne 2019 Mar 8. Epub 2019 Mar 8.

Département de médecine interne et pneumologie, hôpital de la Cavale-Blanche, CHRU de Brest, boulevard Tanguy-Prigent, 29200 Brest, France; Groupe d'étude de la thrombose de Bretagne Occidentale, équipe d'accueil 3878, CHRU de Brest, 29200 Brest, France; Centre d'investigation clinique, Inserm 1412, université de Bretagne Occidentale, 29200 Brest, France.

Azithromycin is a macrolide widely used in chronic bronchial diseases due to its anti-inflammatory properties. This treatment is prescribed to patients with bronchiectasis, asthma and severe chronic obstructive pulmonary disease who present more than 3 exacerbations per year or a deterioration of respiratory function despite an optimal treatment. Macrolides decrease the number of exacerbation but azythromycine must be prescribed carefully. Read More

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http://dx.doi.org/10.1016/j.revmed.2019.02.005DOI Listing
March 2019
2 Reads

Evaluation and management of Idiopathic Pulmonary Fibrosis.

Authors:
Tomoo Kishaba

Respir Investig 2019 Mar 7. Epub 2019 Mar 7.

Department of Respiratory Medicine, Okinawa Chubu Hospital, Miyazato 281, Uruma City, Okinawa 〒904-2293, Japan. Electronic address:

Idiopathic Pulmonary Fibrosis (IPF) is a most common progressive interstitial lung disease (ILD) of unknown etiology, although majority of patients are elderly male smokers. The main pathogenesis is aberrant recovery of epithelial injury and collagen deposition. Fibrotic nonspecific interstitial pneumonia, connective tissue disease (CTD) especially rheumatoid arthritis (RA) associated ILD, and chronic hypersensitivity pneumonia(CHP) are important differential diagnosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22125345183026
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http://dx.doi.org/10.1016/j.resinv.2019.02.003DOI Listing
March 2019
5 Reads

Safety and efficacy of transcatheter embolization in patients with massive hemoptysis due to intercostal pulmonary venous shunts.

Radiol Med 2019 Mar 9. Epub 2019 Mar 9.

First College of Clinical Medical Science, China Three Gorges University, Yichang, 443003, China.

Purpose: Bronchial hemoptysis induced by intercostal pulmonary venous shunt (IPVS) is clinically rare. Pulmonary lesions on pleural surface may facilitate opening of vascular network. This retrospective study investigated safety and efficacy of embolization agents with small-particle embolization treating patients with massive hemoptysis due to IPVS. Read More

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http://dx.doi.org/10.1007/s11547-019-01020-0DOI Listing
March 2019
1 Read

Ambient carbon monoxide and increased risk of daily hospital outpatient visits for respiratory diseases in Dongguan, China.

Sci Total Environ 2019 Feb 22;668:254-260. Epub 2019 Feb 22.

School of Public Health, Southern Medical University, Guangzhou 510515, China; Guangdong Provincial Institute of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, China. Electronic address:

Background: The toxicity of high-concentration carbon monoxide (CO) on human health has previously been documented. However, the epidemiological evidence on the association between acute exposure to ambient CO and respiratory diseases is relatively lacking and controversial.

Objectives: To examine the short-term association between ambient CO and hospital outpatient visits for respiratory diseases in Dongguan, China. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.02.333DOI Listing
February 2019
1 Read

Why chronic cough in children is different.

Pulm Pharmacol Ther 2019 Mar 6. Epub 2019 Mar 6.

Paediatric Asthma and Cough Centre, University and Research Hospitals, Gruppo Ospedaliero San Donato, Bergamo, Italy.

Recently, there have been robust changes in our knowledge of the neurophysiology of cough and novel clinical etiologies. Specifically, cough hypersensitivity in adults and protracted bacterial bronchitis (PBB) in children have been increasingly investigated, and differences between chronic cough in children and adults have been widely reported. In young children, postinfectious cough, bronchiectasis, airway malacia, PBB, and asthma appear to be the main causes of cough; however, by adolescence, the causes of cough are more likely to become those common in adults, namely, gastroesophageal reflux, asthma, and upper airway syndrome. Read More

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http://dx.doi.org/10.1016/j.pupt.2019.03.001DOI Listing
March 2019
5 Reads

Ciprofloxacin Dry Powder for Inhalation: Inspiratory Flow in Patients with Non-cystic Fibrosis Bronchiectasis.

J Aerosol Med Pulm Drug Deliv 2019 Mar 8. Epub 2019 Mar 8.

3 Chrestos Concept GmbH & Co. KG, Essen, Germany.

Background: As non-cystic fibrosis bronchiectasis (NCFB) progresses, patients suffer irreversible lung damage and deterioration in lung function. This study explored whether inhalational parameters (peak inspiratory flow [PIF, primary endpoint], inspiratory volume and time [secondary endpoints]) represent barriers to complete dosing in patients with poor lung function who are using Ciprofloxacin dry powder for inhalation (DPI) (a drug-device combination of the T-326 inhaler device and a Ciprofloxacin dry powder formulation).

Methods: This open-label, multicenter study generated inspiratory flow rate data from patients with NCFB using the breath-actuated T-326 dry powder inhaler. Read More

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http://dx.doi.org/10.1089/jamp.2018.1464DOI Listing
March 2019
1 Read

Chronic Bacterial Infection Prevalence, Risk Factors, and Characteristics: A Bronchiectasis Population-Based Prospective Study.

J Clin Med 2019 Mar 6;8(3). Epub 2019 Mar 6.

Pulmonology Department, Centro Hospitalar S. João, 4200-319 Porto, Portugal.

Background: Few data are available on chronic bacterial infections (CBI) in bronchiectasis patients. Given that CBI seems to trigger longer hospital stays, worse outcomes, and morbimortality, this study was undertaken to assess CBI prevalence, characteristics, and risk factors in outpatients with bronchiectasis.

Methods: A total of 186 patients followed in a bronchiectasis tertiary referral centre in Portugal were included. Read More

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http://dx.doi.org/10.3390/jcm8030315DOI Listing
March 2019
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Pulmonary function and respiratory health after successful treatment of drug-resistant tuberculosis.

Int J Infect Dis 2019 Mar 4. Epub 2019 Mar 4.

Division of Infectious Diseases Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA.

Background: Post-treatment morbidity among subjects withdrug-resistant tuberculosis (DR-TB) is unclear.

Methods: A cross-sectionalstudyof cavitary DR-TB subjects with an outcome of cure from Tbilisi, Georgia. Participants had a chest x-ray (CXR), St. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.02.039DOI Listing
March 2019
2 Reads

Under- and over-diagnosis of COPD: a global perspective.

Breathe (Sheff) 2019 Mar;15(1):24-35

Population Health Research Institute, Division of Respirology, Dept of Medicine, McMaster University, Hamilton, ON, Canada.

Globally, chronic obstructive pulmonary disease (COPD) is the fourth major cause of mortality and morbidity and projected to rise to third within a decade as our efforts to prevent, identify, diagnose and treat patients at a global population level have been insufficient. The European Respiratory Society and American Thoracic Society, along with the Global Initiative for Chronic Obstructive Lung Disease (GOLD) strategy document, have highlighted key pathological risk factors and suggested clinical treatment strategies in order to reduce the mortality and morbidity associated with COPD. This review focuses solely on issues related to the under- and over-diagnosis of COPD across the main geographical regions of the world and highlights some of the associated risk factors. Read More

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http://dx.doi.org/10.1183/20734735.0346-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395975PMC
March 2019
1 Read

Prevalence and clinical implications of chronic rhinosinusitis in people with bronchiectasis: a systematic review.

J Allergy Clin Immunol Pract 2019 Mar 2. Epub 2019 Mar 2.

Department of Physiotherapy, School of Primary and Allied Health Care, Monash University, McMahons Road, Frankston, 3199; Institute for Breathing and Sleep, Austin Health, 145 Studley Road, Heidelberg, 3084; Physiotherapy, Rehabilitation, Nutrition and Sport, La Trobe University, Plenty Road and Kingsbury Drive, Bundoora, 3086. Electronic address:

Background: Chronic rhinosinusitis (CRS) is an extrapulmonary manifestation in some individuals with bronchiectasis, but the prevalence of CRS in this population and its clinical impact has not been systematically reviewed.

Objective: To systematically review the prevalence of CRS in bronchiectasis and identify its clinical implications.

Methods: Four databases were searched from inception to August 2018 for studies reporting prevalence and/or clinical impact of CRS in individuals with bronchiectasis. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.02.026DOI Listing
March 2019
1 Read

Vitamin D and disease severity in bronchiectasis.

Respir Med 2019 Mar 24;148:1-5. Epub 2019 Jan 24.

Respiratory Medicine, AOU "Policlinico - Vittorio Emanuele", University of Catania, Catania, Italy.

Background: Bronchiectasis is a complex respiratory disease characterised by permanent dilatation of bronchi. Vitamin D plays a role in infective disease by modulating the inflammation. Patients affected by bronchiectasis are frequently Vitamin D deficient and it correlates with lung function decline. Read More

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http://dx.doi.org/10.1016/j.rmed.2019.01.009DOI Listing
March 2019
1 Read

Imaging Findings of Pulmonary Nocardiosis Mimicking Bronchiectasis.

J Coll Physicians Surg Pak 2019 Mar;29(3):278-280

Department of Respiratory Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Nocardia species usually cause opportunistic infections, and the frequency of these infections is increasing owing to the growing population of immunocompromised hosts. However, Nocardia may sometimes causes an infectious disease in immunocompetent hosts. Herein, we report two cases of pulmonary nocardiasis in immunocompetent individuals, whose chest computed tomography (CT) findings mimicked bronchiectasis. Read More

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http://dx.doi.org/10.29271/jcpsp.2019.03.278DOI Listing
March 2019
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Biofilm Formations in Pediatric Respiratory Tract Infection : Part 1: Biofilm Structure, Role of Innate Immunity in Protection Against and Response to Biofilm, Methods of Biofilm Detection, Pediatric Respiratory Tract Diseases Associated with Mucosal Biofilm Formation.

Authors:
Daniel L Hamilos

Curr Infect Dis Rep 2019 Feb 28;21(2). Epub 2019 Feb 28.

Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, 55 Fruit Street, Bulfinch-422, Boston, MA, 02114, USA.

Purpose Of Review: Biofilm represents an organized structure of microorganisms within an extracellular matrix attached to a surface. While the importance of biofilm in prosthetic heart valve and catheter-related infections has been known since the 1980s, the role of mucosal biofilm in human disease pathogenesis has only recently been elucidated. It is now clear that mucosal biofilm is present in both healthy and pathologic states. Read More

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http://link.springer.com/10.1007/s11908-019-0658-9
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http://dx.doi.org/10.1007/s11908-019-0658-9DOI Listing
February 2019
4 Reads

The significant global economic burden of bronchiectasis: a pending matter.

Eur Respir J 2019 Feb 28;53(2). Epub 2019 Feb 28.

Pneumology Dept, University and Politechnic La Fe Hospital, Valencia, Spain.

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http://dx.doi.org/10.1183/13993003.02392-2018DOI Listing
February 2019
1 Read

The economic burden of bronchiectasis - known and unknown: a systematic review.

BMC Pulm Med 2019 Feb 28;19(1):54. Epub 2019 Feb 28.

Scottish Centre for Respiratory Research, University of Dundee, Dundee, UK.

Background: The increasing prevalence and recognition of bronchiectasis in clinical practice necessitates a better understanding of the economic disease burden to improve the management and achieve better clinical and economic outcomes. This study aimed to assess the economic burden of bronchiectasis based on a review of published literature.

Methods: A systematic literature review was conducted using MEDLINE, Embase, EconLit and Cochrane databases to identify publications (1 January 2001 to 31 December 2016) on the economic burden of bronchiectasis in adults. Read More

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http://dx.doi.org/10.1186/s12890-019-0818-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393984PMC
February 2019
1 Read

Healthcare professionals' views of palliative care for American war veterans with non-malignant respiratory disease living in a rural area: a qualitative study.

BMC Palliat Care 2019 Feb 27;18(1):22. Epub 2019 Feb 27.

Pulmonary and MICU, Boise VA Medical Centre, Boise, USA.

Background: Chronic lung diseases, such as COPD, are a growing health concern within the veteran population. Palliative care programs have mainly focused on the needs of people with malignant disease in the past, however the majority of those worldwide needing palliative care have a non-malignant diagnosis. Additionally, palliative care provision can often be fragmented and varied dependent upon a patient's geographical location. Read More

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http://dx.doi.org/10.1186/s12904-019-0408-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394001PMC
February 2019

Proceedings of the 3rd BEAT-PCD Conference and 4th PCD Training School.

BMC Proc 2018 18;12(Suppl 16):64. Epub 2018 Dec 18.

Danish PCD & Child Centre, CF Centre Copenhagen, Paediatric Pulmonary Service, ERN Accredited, Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Denmark.

Primary ciliary dyskinesia (PCD) is a chronic suppurative airways disease that is usually recessively inherited and has marked clinical phenotypic heterogeneity. Classic symptoms include neonatal respiratory distress, chronic rhinitis since early childhood, chronic otitis media, recurrent airway infections leading to bronchiectasis, chronic sinusitis, laterality defects with and without congenital heart disease including abnormal situs in approximately 50% of the cases, and male infertility. Lung function deteriorates progressively from childhood throughout life. Read More

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http://dx.doi.org/10.1186/s12919-018-0161-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297936PMC
December 2018
1 Read

Pathophysiology, causes and genetics of paediatric and adult bronchiectasis.

Respirology 2019 Feb 25. Epub 2019 Feb 25.

Department of Respiratory Biology, University of Cambridge, Cambridge, UK.

Bronchiectasis has historically been considered to be irreversible dilatation of the airways, but with modern imaging techniques it has been proposed that 'irreversible' be dropped from the definition. The upper limit of normal for the ratio of airway to arterial development increases with age, and a developmental perspective is essential. Bronchiectasis (and persistent bacterial bronchitis, PBB) is a descriptive term and not a diagnosis, and should be the start not the end of the patient's diagnostic journey. Read More

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http://dx.doi.org/10.1111/resp.13509DOI Listing
February 2019
4 Reads

Cough of more than two weeks - Time to think beyond pulmonary TB.

Indian J Tuberc 2019 Jan 7;66(1):44-48. Epub 2017 Jun 7.

Medical Officer and Statistician, Base Hospital, New Delhi, India.

Background: Cough of more than two weeks has become sine quo non with pulmonary tuberculosis (PTB) in a developing country like India. The causes may be different in patients reporting to respiratory OPD vis a vis general OPD.

Aims And Objectives: To study the prevalence of PTB and causes of cough other than PTB among respiratory OPD attendees with cough of more than two weeks duration. Read More

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http://dx.doi.org/10.1016/j.ijtb.2017.05.007DOI Listing
January 2019
2 Reads

Increased susceptibility of airway epithelial cells from ataxia-telangiectasia to S. pneumoniae infection due to oxidative damage and impaired innate immunity.

Sci Rep 2019 Feb 22;9(1):2627. Epub 2019 Feb 22.

Neuroscience & Infectious Disease Group, The University of Queensland Centre for Clinical Research, Herston, Queensland, Australia.

Respiratory disease is a major cause of morbidity and mortality in patients with ataxia-telangiectasia (A-T) who are prone to recurrent sinopulmonary infections, bronchiectasis, pulmonary fibrosis, and pulmonary failure. Upper airway infections are common in patients and S. pneumoniae is associated with these infections. Read More

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http://dx.doi.org/10.1038/s41598-019-38901-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385340PMC
February 2019
2 Reads

Lung disease in STAT3-Hyper-IgE-Syndrome requires intense therapy.

Allergy 2019 Feb 21. Epub 2019 Feb 21.

Environmental Medicine, UNIKA-T, Technical University of Munich and HelmholtzZentrum Munich, Munich/Augsburg, Germany.

Background: Pulmonary complications are responsible for high morbidity and mortality rates in patients with the rare immunodeficiency disorder STAT3 hyper-IgE syndrome (STAT3-HIES). The aim of this study was to expand knowledge about lung disease in STAT3-HIES.

Methods: The course of pulmonary disease, radiological and histopathological interrelations, therapeutic management, and the outcome of 14 STAT3-HIES patients were assessed. Read More

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http://dx.doi.org/10.1111/all.13753DOI Listing
February 2019
1 Read
6.028 Impact Factor

Primary ciliary dyskinesia among Arabs: Where do we go from here?

Paediatr Respir Rev 2018 Sep 15. Epub 2018 Sep 15.

Medical Research Center, Research Affairs, Hamad Medical Corporation, PO Box 3050, Doha, Qatar; Pediatric Pulmonology, Sidra Medicine, PO Box 2699, Doha, Qatar. Electronic address:

Primary ciliary dyskinesia (PCD), also known as immotile-cilia syndrome, is a rare genetic disease that is inherited in an autosomal recessive manner. Several studies have explored certain aspects of PCD in the Arab world, yet much is still lacking in terms of identifying the different characteristics of this disease. In this paper, we aim to briefly cover those studies published about PCD in Arab countries, as well as to provide recommendations and guidelines for future studies. Read More

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http://dx.doi.org/10.1016/j.prrv.2018.09.002DOI Listing
September 2018
2 Reads
2.196 Impact Factor

Prognostic significance of crazy paving ground grass opacities in non-HIV Pneumocystis jirovecii pneumonia: an observational cohort study.

BMC Pulm Med 2019 Feb 21;19(1):47. Epub 2019 Feb 21.

Department of Respiratory Medicine, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki, Okayama, 710-0052, Japan.

Background: In patients with non-HIV Pneumocystis jirovecii pneumonia (PjP), computed tomography imaging reveals ground grass opacities (GGO). Previous reports show that some patients with non-HIV PjP exhibit GGO with crazy paving. However, there have been no studies on the association between crazy paving GGO and non-HIV PjP clinical outcomes. Read More

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http://dx.doi.org/10.1186/s12890-019-0813-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385404PMC
February 2019
2 Reads

National Survey on the Management of Adult Bronchiectasis in Belgium.

COPD 2019 Feb 21:1-3. Epub 2019 Feb 21.

a Department of Respiratory Medicine , University Hospitals Leuven , Leuven , Belgium.

The increasing prevalence and incidence of bronchiectasis leads to a substantial health care burden. Quality standards for the management of bronchiectasis were formulated by the British Thoracic Society following publication of guidelines in 2010. They can be used as a benchmark for quality of care. Read More

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http://dx.doi.org/10.1080/15412555.2019.1566895DOI Listing
February 2019

Severe asthma and bronchiectasis.

J Asthma 2019 Feb 20:1-5. Epub 2019 Feb 20.

a Department of Pneumology , Hospital Universitario Central de Asturias , Oviedo , Spain.

Objective: The aim of our study was to determine the tomographic findings and prevalence of bronchiectasis in our population of patients with severe asthma, and to identify factors associated with the presence of bronchiectasis in these patients.

Materials And Methods: We retrospectively collected data from the medical histories of patients referred to the asthma unit of our hospital, with a diagnosis of severe asthma between 2015 and 2017. Patients with ABPA, cystic fibrosis, immunodeficiency or systemic disease were excluded. Read More

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http://dx.doi.org/10.1080/02770903.2019.1579832DOI Listing
February 2019
1 Read

Successful control of exacerbation of Allergic Bronchopulmonary Aspergillosis due to Aspergillus terreus in a cystic fibrosis patient with short-term adjunctive therapy with voriconazole: A case report.

J Mycol Med 2019 Feb 16. Epub 2019 Feb 16.

Invasive Fungi Research Center (IFRC)/ Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

A 12-year-old boy with cystic fibrosis (CF) and a history of glucocorticoid-dependent allergic bronchopulmonary aspergillosis (ABPA) was referred to our hospital. The ABPA was diagnosed when he was 8 years old and he had been treated with several course of oral glucocorticoids for recurrent exacerbations. He was readmitted when aged 12 with a history of worsening shortness of breath and chest tightness. Read More

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http://dx.doi.org/10.1016/j.mycmed.2019.02.001DOI Listing
February 2019
1 Read

Paediatric and adult bronchiectasis: Diagnosis, disease burden and prognosis.

Respirology 2019 Feb 19. Epub 2019 Feb 19.

Division of Pulmonary Medicine, Department of Medicine, University of Alberta, Edmonton, AB, Canada.

Bronchiectasis is a chronic, debilitating disease with increasing worldwide prevalence and burden. Accurate and early diagnosis is essential for both its management and prognosis. This review will discuss the diagnosis of bronchiectasis, the international burden of the disease and its current prognosis. Read More

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http://dx.doi.org/10.1111/resp.13495DOI Listing
February 2019
1 Read

Targeting IL-17 attenuates hypoxia-induced pulmonary hypertension through downregulation of β-catenin.

Thorax 2019 Feb 18. Epub 2019 Feb 18.

Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Capital Medical University, Beijing, China.

Background: The role of interleukin 17 (IL-17) in hypoxic pulmonary hypertension (HPH) remains unclear. This study is designed to explore whether IL-17 is a potential target for HPH treatment.

Methods: Clinic samples from the lung tissue and serum were obtained from qualified patients. Read More

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http://dx.doi.org/10.1136/thoraxjnl-2018-211846DOI Listing
February 2019
2 Reads

Help, hinder, hide and harm: what can we learn from the interactions between and during respiratory infections?

Thorax 2019 Feb 18. Epub 2019 Feb 18.

Departments of Pediatrics and Microbiology, University of Washington, Seattle, Washington, USA.

Recent studies of human respiratory secretions using culture-independent techniques have found a surprisingly diverse array of microbes. Interactions among these community members can profoundly impact microbial survival, persistence and antibiotic susceptibility and, consequently, disease progression. Studies of polymicrobial interactions in the human microbiota have shown that the taxonomic and structural compositions, and resulting behaviours, of microbial communities differ substantially from those of the individual constituent species and in ways of clinical importance. Read More

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http://dx.doi.org/10.1136/thoraxjnl-2018-212616DOI Listing
February 2019
1 Read

Effect of airway clearance techniques in patients experiencing an acute exacerbation of bronchiectasis: a systematic review.

Physiother Theory Pract 2019 Feb 18:1-16. Epub 2019 Feb 18.

a Faculty of Health Sciences and Medicine , Bond University , Robina , QLD , Australia.

Background: Airway clearance techniques (ACTs) are recommended for people with bronchiectasis both in stable state and during an acute exacerbation. Research has previously investigated ACTs for individuals in a stable state, but the safety and efficacy of ACTs during an acute exacerbation has not been reviewed.

Methods: A systematic review was completed for studies of ACTs undertaken in adults and children experiencing an acute exacerbation of bronchiectasis. Read More

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http://dx.doi.org/10.1080/09593985.2019.1579286DOI Listing
February 2019
3 Reads

Surgical Treatment of Bronchiectasis: 5 Years of Experience at a Single Institution.

J Laparoendosc Adv Surg Tech A 2019 Feb 15. Epub 2019 Feb 15.

Department of Thoracic Surgery, The Second Hospital Affiliated to Harbin Medical University, Harbin, China.

Objective: The aim of this retrospective study was to present our surgical experience in patients with bronchiectasis who underwent thoracoscopy and to compare the results with those of patients who underwent thoracotomy.

Methods: We analyzed the medical records of patients who underwent lung resection to treat bronchiectasis through video-assisted thoracoscopic surgery (VATS) or open lung resection between November 2012 and November 2017.

Results: In total, 99 patients were enrolled. Read More

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https://www.liebertpub.com/doi/10.1089/lap.2018.0694
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http://dx.doi.org/10.1089/lap.2018.0694DOI Listing
February 2019
3 Reads

Allergic bronchopulmonary aspergillosis presumably unmasked by PD-1 inhibition.

BMJ Case Rep 2019 Feb 13;12(2). Epub 2019 Feb 13.

Pulmonary and Critical Care, Tower Health System, West Reading, Pennsylvania, USA.

Programmed cell death-1 (PD-1) inhibitors stimulate immune recognition of tumour cells in cancer patients, but have significant autoimmune side effects including pneumonitis. We report the case of a patient with asthma and mild eosinophilia who developed unusual pulmonary side effect of bronchiectasis, severe eosinophilia (absolute eosinophil count: 3200 c/mm) and elevated IgE levels (7050 IU/mL; normal: <164 IU/mL) 4 months into therapy with the PD-1 inhibitor pembrolizumab. Aspergillus fumigatus IgG was elevated at 15. Read More

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http://dx.doi.org/10.1136/bcr-2018-227814DOI Listing
February 2019
2 Reads

CT evaluation of hyperattenuating mucus to diagnose allergic bronchopulmonary aspergillosis in the special condition of cystic fibrosis.

J Cyst Fibros 2019 Feb 12. Epub 2019 Feb 12.

CHU de Bordeaux, Service d'Imagerie Thoracique et Cardiovasculaire, Service des Maladies Respiratoires, Service d'Exploration Fonctionnelle Respiratoire, Unité de Pneumologie pédiatrique, Service de Parasitologie-Mycologie, CIC 1401, F-33600 Pessac, France; Univ. Bordeaux, Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, CIC 1401, F-33000 Bordeaux, France; Inserm, Centre de Recherche Cardio-Thoracique de Bordeaux, U1045, CIC 1401, F-33000 Bordeaux, France. Electronic address:

Background: Mucus plugging (MP), central bronchiectasis (CB), and consolidation/atelectasia (CA) are conventional CT signs to diagnose allergic bronchopulmonary aspergillosis (ABPA) in cystic fibrosis (CF). Hyperattenuating mucus (HAM) has recently been described and may improve diagnostic accuracy. The goal of our study was to compare HAM versus conventional CT signs to diagnose ABPA in CF. Read More

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http://dx.doi.org/10.1016/j.jcf.2019.02.002DOI Listing
February 2019
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New insights into immunological responses to infection in bronchiectasis.

Eur Respir J 2019 Feb 7;53(2). Epub 2019 Feb 7.

Royal Brompton and Harefield NHS Foundation Trust and Imperial College, London, UK.

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http://erj.ersjournals.com/lookup/doi/10.1183/13993003.02395
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http://dx.doi.org/10.1183/13993003.02395-2018DOI Listing
February 2019
4 Reads

Single-breath washout and association with structural lung disease in children with cystic fibrosis.

Pediatr Pulmonol 2019 Feb 13. Epub 2019 Feb 13.

Respiratory Medicine, Royal Children's Hospital, Melbourne, Victoria, Australia.

Background: In children with cystic fibrosis (CF) lung clearance index (LCI) from multiple-breath washout (MBW) correlates with structural lung disease. As a shorter test, single-breath washout (SBW) represents an attractive alternative to assess the ventilation distribution, however, data for the correlation with lung imaging are lacking.

Methods: We assessed correlations between phase III slope (SIII) of double-tracer gas SBW, nitrogen MBW indices (LCI and moment ratios for overall ventilation distribution, Scond, and Sacin for conductive and mainly acinar ventilation, respectively) and structural lung disease assessed by chest computed tomography (CT) in children with CF. Read More

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http://dx.doi.org/10.1002/ppul.24271DOI Listing
February 2019
2 Reads

Thymic neoplasms patients complicated with bronchiectasis: Case series in a Chinese hospital and literature review.

Thorac Cancer 2019 Feb 13. Epub 2019 Feb 13.

Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Background: Bronchiectasis is a rare complication in patients with thymic neoplasm. The aim of this study was to investigate the clinical and radiological manifestations, laboratory tests, pathologic features, and outcome of treatment of bronchiectasis in patients with thymic neoplasm.

Methods: From January 2000 to January 2018, 20 patients with a diagnosis of thymic neoplasm and bronchiectasis were hospitalized at the Peking Union Medical College Hospital. Read More

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http://dx.doi.org/10.1111/1759-7714.13000DOI Listing
February 2019
4 Reads
1.126 Impact Factor

Not All Strokes Are Strokes An Example of Diagnostic Confirmation Bias.

Eur J Case Rep Intern Med 2019 8;6(1):001006. Epub 2019 Jan 8.

West Middlesex University Hospital, London, United Kingdom.

A 72-year-old woman presented with a complex partial seizure and right hemiparesis, after a four-week history of cognitive decline, apraxia and speech disturbance. She previously had chronic lymphocytic leukaemia (CLL) and had finished chemotherapy one year prior to presentation. She was receiving monthly intravenous immunoglobulins for bronchiectasis. Read More

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http://dx.doi.org/10.12890/2019_001006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372046PMC
January 2019
4 Reads

Bronchoscopy to assess patients with hemoptysis: which is the optimal timing?

BMC Pulm Med 2019 Feb 11;19(1):36. Epub 2019 Feb 11.

Clinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical, Experimental Sciences, University of Sassari, Sassari, Italy.

Background: Bronchoscopy plays a key role to diagnose the etiology, to localize the site, and to identify the sources of the bleeding in patients with hemoptysis, but the ideal timing of an endoscopic examination is still unclear.

Methods: We performed a secondary analysis of an observational and multicenter study, aimed at evaluating the epidemiology of hemoptysis in Italy and the diagnostic yield of the most frequently prescribed examinations. The aim of the study was to evaluate whether an early bronchoscopy (i. Read More

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https://bmcpulmmed.biomedcentral.com/articles/10.1186/s12890
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http://dx.doi.org/10.1186/s12890-019-0795-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6371580PMC
February 2019
8 Reads

Contemporary Concise Review 2018: Bronchiectasis.

Respirology 2019 Apr 11;24(4):382-389. Epub 2019 Feb 11.

School of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD, Australia.

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http://dx.doi.org/10.1111/resp.13502DOI Listing
April 2019
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Correction to: Hospital organizational context and delivery of evidence-based stroke care: a cross-sectional study.

Implement Sci 2019 Feb 8;14(1):13. Epub 2019 Feb 8.

Stroke and Ageing Research, Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Level 3, Hudson Institute Building, 27-31 Wright Street, Clayton, VIC, 3168, Australia.

Following publication of the original article [1], the authors reported an error in one of the authors' names. In this Correction the incorrect and correct author name are shown. The original article has been corrected. Read More

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http://dx.doi.org/10.1186/s13012-019-0862-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367782PMC
February 2019
2 Reads

Comparison of different conditions for DNA extraction in sputum - a pilot study.

Multidiscip Respir Med 2019 31;14. Epub 2019 Jan 31.

1University of Milan, Department of Pathophysiology and Transplantation, Via Francesco Sforza 35, 20122 Milan, Italy.

Background: The analysis of microbiome in respiratory samples is a topic of great interest in chronic respiratory diseases. The method used to prepare sputum samples for microbiome analysis is very heterogeneous. The selection of the most suitable methodology for DNA extraction is fundamental to have the most representative data. Read More

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http://dx.doi.org/10.1186/s40248-018-0166-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357456PMC
January 2019
1 Read