15,008 results match your criteria Bronchiectasis


Risk factors of clinically significant complications in transbronchial lung cryobiopsy: A prospective multi-center study.

Respir Med 2022 Jun 21;200:106922. Epub 2022 Jun 21.

Center of Medicine and Clinical Research, Division of Respiratory Medicine, Kuopio University Hospital, POB 100, 70029, Kuopio, Finland.

Background: The use of a transbronchial lung cryobiopsy (TBLC) is increasing as a diagnostic method of interstitial lung diseases (ILD). This study aimed to evaluate risk factors associated with clinically significant complications of TBLC in ILD patients.

Methods: Patients referred to Kuopio or Tampere university hospitals, in Finland, for a suspected ILD were included. Read More

View Article and Full-Text PDF

Can deep learning improve image quality of low-dose CT: a prospective study in interstitial lung disease.

Eur Radiol 2022 Jun 24. Epub 2022 Jun 24.

Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China.

Objectives: To investigate whether deep learning reconstruction (DLR) could keep image quality and reduce radiation dose in interstitial lung disease (ILD) patients compared with HRCT reconstructed with hybrid iterative reconstruction (hybrid-IR).

Methods: Seventy ILD patients were prospectively enrolled and underwent HRCT (120 kVp, automatic tube current) and LDCT (120 kVp, 30 mAs) scans. HRCT images were reconstructed with hybrid-IR (Adaptive Iterative Dose Reduction 3-Dimensional [AIDR3D], standard-setting); LDCT images were reconstructed with DLR (Advanced Intelligence Clear-IQ Engine [AiCE], lung/bone, mild/standard/strong setting). Read More

View Article and Full-Text PDF

Exacerbation of Eosinophilic Granulomatosis With Polyangiitis After Administering Dupilumab for Severe Asthma and Eosinophilic Rhinosinusitis With Nasal Polyposis.

Cureus 2022 May 22;14(5):e25218. Epub 2022 May 22.

Respiratory Medicine, Japanese Red Cross Society Kyoto Daiichi Hospital, Kyoto, JPN.

Eosinophilic granulomatosis with polyangiitis (EGPA) refers to systemic vasculitis in patients with bronchial asthma and eosinophilic rhinosinusitis. Dupilumab has been approved for the treatment of asthma, eosinophilic rhinosinusitis, and atopic dermatitis. A man in his 50s with a history of asthma and eosinophilic rhinosinusitis with nasal polyposis developed high fever and dyspnea while undergoing dupilumab treatment. Read More

View Article and Full-Text PDF

A Stargardt disease-like phenotype in -related primary ciliary dyskinesia.

Authors:
Arif O Khan

Ophthalmic Genet 2022 Jun 23:1-3. Epub 2022 Jun 23.

Eye Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates.

Purpose: Ciliopathies are broadly classified as non-motile or motile (primary ciliary dyskinesia). Early-onset retinal dystrophy is common in non-motile ciliopathy, but retinal dystrophy is not considered a feature of primary ciliary dyskinesia. The subject of this report is woman referred as a case of Stargardt disease who in fact had retinal dystrophy apparently related to -related primary ciliary dyskinesia. Read More

View Article and Full-Text PDF

Deadly dust: Silicotuberculosis as a downplayed and overlooked fatal disease in Indonesia.

Ann Med Surg (Lond) 2022 Jun 17;78:103794. Epub 2022 May 17.

Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Airlangga - Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.

Background: Silicosis is one of the most common diseases among all occupational diseases. The main clinical focus on the silicosis complication will be tuberculosis.

Case Presentation: A 28-year-old male presented with complaints of chronic dry cough, weight loss, decreased appetite, and night sweats. Read More

View Article and Full-Text PDF

Allergic Bronchopulmonary Aspergillosis with an Atypical Mass-Like Presentation.

Case Rep Pulmonol 2022 13;2022:3627202. Epub 2022 Jun 13.

Imam Abdulrahman Bin Faisal University, King Fahd Hospital of the University, Respiratory Medicine Unit, Al Khobar, Saudi Arabia.

Allergic bronchopulmonary aspergillosis is an uncommon condition characterized by airway hypersensitivity to Aspergillus fumigatus, resulting in worsening asthma control and bronchiectasis progression. It is associated with various radiological features. Here, we describe a 53-year-old lady with atypical CT chest finding as soft tissue density masses in both lungs evaluated initially as a lung tumour. Read More

View Article and Full-Text PDF

Macrophage PD-1 associates with neutrophilia and reduced bacterial killing in early cystic fibrosis airway disease.

J Cyst Fibros 2022 Jun 19. Epub 2022 Jun 19.

Department of Pediatrics, Center for CF & Airways Disease Research, Children's Healthcare of Atlanta, IMPEDE-CF Program, Emory University School of Medicine, Atlanta, GA, United States of America. Electronic address:

Background: Macrophages are the major resident immune cells in human airways coordinating responses to infection and injury. In cystic fibrosis (CF), neutrophils are recruited to the airways shortly after birth, and actively exocytose damaging enzymes prior to chronic infection, suggesting a potential defect in macrophage immunomodulatory function. Signaling through the exhaustion marker programmed death protein 1 (PD-1) controls macrophage function in cancer, sepsis, and airway infection. Read More

View Article and Full-Text PDF

Emerging medicines to improve the basic defect in cystic fibrosis.

Expert Opin Emerg Drugs 2022 Jun 22. Epub 2022 Jun 22.

Université de Paris, Faculté de Médecine, Paris, France.

Introduction: Cystic fibrosis (CF) is a severe autosomal recessive disorder featuring exocrine pancreatic insufficiency and bronchiectasis. It is caused by mutations in the cystic fibrosis transmembrane conductance regulator gene () encoding the CFTR protein which is an anion channel. CF treatment has long been based only on intensive symptomatic treatment. Read More

View Article and Full-Text PDF

Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening.

Cell Death Dis 2022 Jun 21;13(6):559. Epub 2022 Jun 21.

Department of Pediatric Pulmonology and Immunology, West China Second University Hospital, Sichuan University, Chengdu, China.

Primary cilia dyskinesia (PCD) is a rare genetic disease caused by ciliary structural or functional defects. It causes severe outcomes in patients, including recurrent upper and lower airway infections, progressive lung failure, and randomization of heterotaxy. To date, although 50 genes have been shown to be responsible for PCD, the etiology remains elusive. Read More

View Article and Full-Text PDF

Genome sequencing reveals underdiagnosis of primary ciliary dyskinesia in bronchiectasis.

Eur Respir J 2022 Jun 21. Epub 2022 Jun 21.

Genetics and Genomic Medicine Department, University College London, UCL Great Ormond Street Institute of Child Health, London, UK.

Background: Bronchiectasis can result from infectious, genetic, immunological and allergic causes. 60-80% cases are idiopathic, but a well-recognised genetic cause is the motile ciliopathy, primary ciliary dyskinesia (PCD). Diagnosis of PCD has management implications including addressing co-morbidities, implementing genetic and fertility counselling and future access to PCD-specific treatments. Read More

View Article and Full-Text PDF

Task Force report: European Respiratory Society statement for defining respiratory exacerbations in children and adolescents with bronchiectasis for clinical trials.

Eur Respir J 2022 Jun 21. Epub 2022 Jun 21.

Pediatric Asthma and Cough Centre, Istituti Ospedalieri Bergamaschi, University and Research Hospitals, Bergamo, Italy.

Bronchiectasis is being diagnosed increasingly in children and adolescents. Recurrent respiratory exacerbations are common in children and adolescents with this chronic pulmonary disorder. Respiratory exacerbations are associated with an impaired quality-of-life, poorer long-term clinical outcomes and substantial costs to the family and health systems. Read More

View Article and Full-Text PDF

Childhood 'bronchitis' and respiratory outcomes in middle-age: a prospective cohort study from age 7 to 53 years.

BMJ Open Respir Res 2022 06;9(1)

Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.

Background: Chronic bronchitis in childhood is associated with a diagnosis of asthma and/or bronchiectasis a few years later, however, consequences into middle-age are unknown.

Objective: To investigate the relationship between childhood bronchitis and respiratory-related health outcomes in middle-age.

Design: Cohort study from age 7 to 53 years. Read More

View Article and Full-Text PDF

Chest wall muscle mass depletion is related to certain pulmonary functions and diseases in patients with bronchiectasis.

Chron Respir Dis 2022 Jan-Dec;19:14799731221105517

Capital Medical University, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.

Background And Objective: Many bronchiectasis patients suffer dyspnea, decreased exercise tolerance, and low body mass index. Chest wall muscles play a special role in respiratory movement and make up parts of skeletal muscles. This study aimed to examine the chest wall muscle thickness and their relationship with disease severity in bronchiectasis. Read More

View Article and Full-Text PDF

A novel therapeutic strategy to close bronchopleural fistula related to in elderly patients: two case reports and literature review.

Ann Transl Med 2022 May;10(10):615

Second Department of Geriatrics Respiratory Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial Geriatrics Institute, Guangzhou, China.

Background: () empyema complicated with bronchopleural fistula (BPF) remains a significant challenge in diagnosis and treatment and the clinical outcomes are often unsatisfactory, especially in elderly patients. There is a paucity data related to the management of the condition. This is the first well-documented report of the therapeutic experience with bronchoscopic closure of a bronchopleural fistula with empyema related to infection in the elderly patients. Read More

View Article and Full-Text PDF

Outcome of paediatric lobectomy by thoracotomy - a single centre, six-year experience.

J Pak Med Assoc 2022 May;72(5):947-949

Department of Surgery, Jinnah Postgraduate Medical Center, Karachi, Pakistan.

This short report highlights the patient outcome of lung resections for congenital and acquired lung lesions in children who presented to the Liaquat National Hospital, Karachi, from January 2013 to April 2019. Common indications were congenital pulmonary airway malformation (CPAM), congenital lobar emphysema (CLE), and bronchiectasis. Two patients died whereas, 21 were discharged home. Read More

View Article and Full-Text PDF

Prospectively evaluating maternal and fetal outcomes in the era of CFTR modulators: the MAYFLOWERS observational clinical trial study design.

BMJ Open Respir Res 2022 06;9(1)

Departments of Internal Medicine and Pediatrics, National Jewish Health, Denver, Colorado, USA

Introduction: Therapeutic advances have markedly increased life expectancy for those with cystic fibrosis (CF), resulting in a median predicted survival over 50 years. Consequently, people with CF (pwCF) are living through their reproductive years and the rate of pregnancy is rapidly rising. Despite the increased relevance of this topic, multicentre studies investigating the association between maternal health and choices made during pregnancy on maternal and fetal outcomes do not exist. Read More

View Article and Full-Text PDF

Delayed diagnosis of foreign body aspiration in children.

Arch Pediatr 2022 Jun 12. Epub 2022 Jun 12.

Hôpital des enfants de Toulouse, 330 Av. de Grande Bretagne, 31300, Toulouse.

Aims: To assess the diagnostic and therapeutic difficulties as well as the long-term complications of prolonged endobronchial foreign body retention.

Method: Between January 2000 and May 2021, 794 patients with suspected foreign body aspiration (FBA) were hospitalized in our department. A total of 12 patients with a delayed diagnosis of over 1 month were included. Read More

View Article and Full-Text PDF

Estimating the Clinical Impact of Photon-Counting-Detector CT in Diagnosing Usual Interstitial Pneumonia.

Invest Radiol 2022 May 6. Epub 2022 May 6.

From the Department of Radiology, Mayo Clinic, Rochester, MN.

Objective: The aim of this study was to evaluate the clinical impact of a higher spatial resolution, full field-of-view investigational photon-counting detector computed tomography (PCD-CT) on radiologist confidence in imaging findings and diagnosis of usual interstitial pneumonia (UIP) compared with conventional energy-integrating detector CT (EID-CT).

Materials And Methods: Patients suspected of interstitial lung disease were scanned on a PCD-CT system after informed consent and a clinically indicated EID-CT. In 2 sessions, 3 thoracic radiologists blinded to clinical history and scanner type evaluated CT images of the right and left lungs separately on EID- or PCD-CT, reviewing each lung once/session, rating confidence in imaging findings of reticulation, traction bronchiectasis, honeycombing, ground-glass opacities (GGOs), mosaic pattern, and lower lobe predominance (100-point scale: 0-33, likely absent; 34-66, indeterminate; 67-100, likely present). Read More

View Article and Full-Text PDF

Prolonged treatment with inhaled ampicillin in children with non-cystic fibrosis bronchiectasis.

Arch Bronconeumol 2021 Oct 13;57(10):662-664. Epub 2021 Aug 13.

Unidad de Neumología Pediátrica, Servicio de Pediatría, Hospital Universitario Virgen del Rocío, Sevilla, Spain. Electronic address:

View Article and Full-Text PDF
October 2021

Effects of Controlled Voluntary Increase in the Ventilatory Demand on Respiratory System Resistance in Healthy and Non-Cystic Fibrosis Bronchiectasis Subjects: A Cross-Sectional Study.

Arch Bronconeumol 2021 Aug;57(8):528-532

Department of Health Sciences, Graduate Program in Functional Performance, Ribeirão Preto Medical School, Ribeirão Preto, São Paulo, Brazil. Electronic address:

Introduction: Bronchiectasis patients may present a reduced functional capacity due to an increase in the ventilatory demand during exercise.

Objective: To evaluate the effects of controlled voluntary hyperinflation and increased respiratory rate on the mechanics of the respiratory system, simulating what happens during exercise, in bronchiectasis and healthy subjects.

Methods: Bronchiectasis (n=30) and healthy (n=16) subjects were evaluated by impulse oscillometry (IOS) during a baseline condition, and in controlled conditions with baseline (b) tidal volume (V) and hyperinflation (H), with respiratory rates at 30(R30) and 40(R40) bpm, in a random order. Read More

View Article and Full-Text PDF

Bronchiectasis and Eosinophils.

Arch Bronconeumol 2021 Nov;57(11):671-672

Servicio de Neumología, Hospital Universitario y Politécnico la Fe de Valencia, Spain. Electronic address:

View Article and Full-Text PDF
November 2021

Factors Associated With One-Year Mortality in Hospitalised Patients With Exacerbated Bronchiectasis.

Arch Bronconeumol 2022 May 13. Epub 2022 May 13.

Fundació Clínic per la Recerca Biomèdica (FCRB), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Biomedical Research Networking Center on Respiratory Diseases (CIBERES), Hospital Clínic of Barcelona, 08036 Barcelona, Spain; Institute of Respiratory Disease, Hospital Clínic of Barcelona, 08036 Barcelona, Spain. Electronic address:

View Article and Full-Text PDF

Chronic lung lesions in COVID-19 survivors: predictive clinical model.

BMJ Open 2022 Jun 13;12(6):e059110. Epub 2022 Jun 13.

Instituto do Coração-Divisão de Pneumologia, Universidade de São Paulo Hospital das Clínicas, Sao Paulo, Brazil.

Objective: This study aimed to propose a simple, accessible and low-cost predictive clinical model to detect lung lesions due to COVID-19 infection.

Design: This prospective cohort study included COVID-19 survivors hospitalised between 30 March 2020 and 31 August 2020 followed-up 6 months after hospital discharge. The pulmonary function was assessed using the modified Medical Research Council (mMRC) dyspnoea scale, oximetry (SpO), spirometry (forced vital capacity (FVC)) and chest X-ray (CXR) during an in-person consultation. Read More

View Article and Full-Text PDF

: insights from a bioinformatic perspective.

Crit Rev Microbiol 2022 Jun 13:1-16. Epub 2022 Jun 13.

Postgraduate Department of Botany, Ramananda College, Bishnupur, India.

is a nontuberculous mycobacterium, associated with broncho-pulmonary infections in individuals suffering from cystic fibrosis, bronchiectasis, and pulmonary diseases. The risk factors for transmission include biofilms, contaminated water resources, fomites, and infected individuals. is extensively resistant to antibiotics. Read More

View Article and Full-Text PDF

'The likes of me running and walking? No chance': Exploring the perceptions of adult patients with bronchiectasis towards exercise.

Chronic Illn 2022 Jun 12:17423953221108223. Epub 2022 Jun 12.

Respiratory Research Centre, Health Research Institute, 6249Edge Hill University, Ormskirk, UK.

To explore the views and experiences of adult patients with bronchiectasis towards exercise. Semi-structured interviews with ten patients with bronchiectasis were conducted to explore perceptions of exercise, potential barriers and facilitators of exercise. Inductive thematic analysis was used to identify key themes. Read More

View Article and Full-Text PDF

Inflammatory response in human lung cells stimulated with plasma from COPD patients.

Multidiscip Respir Med 2022 Jan 24;17:817. Epub 2022 May 24.

Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/Universidad de Sevilla, Seville.

Background: Chronic obstructive pulmonary disease (COPD) is a condition resulting from a persistent inflammatory state in the airways even after smoking cessation. Intriguingly, the reasons behind this persistence of the inflammatory influx without smoking exposure have not been fully unraveled. We aimed to explore the hypothesis that systemic inflammation in COPD patients influences lung cell inflammatory response. Read More

View Article and Full-Text PDF
January 2022

Clinical deterioration and lung function change in patients with concomitant asthma and bronchiectasis.

J Allergy Clin Immunol Pract 2022 Jun 8. Epub 2022 Jun 8.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Republic of Korea.

Background: Only limited data are available regarding the effects of bronchiectasis on the clinical course of asthma.

Objective: This study evaluated longitudinal clinical outcomes according to bronchiectasis status in patients with asthma.

Methods: This retrospective study included patients with asthma who underwent chest computed tomography and pulmonary function tests between January 2013 and December 2019. Read More

View Article and Full-Text PDF

Feasibility of a genotyping system for the diagnosis of alpha1 antitrypsin deficiency: a multinational cross-sectional analysis.

Respir Res 2022 Jun 10;23(1):152. Epub 2022 Jun 10.

CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.

Introduction: Currently, strategies for improving alpha1 antitrypsin deficiency (AATD) diagnosis are needed. Here we report the performance of a multinational multiplex-based genotyping test on dried blood spots and buccal swabs sent by post or courier and with web registration for subjects with suspected AATD in Argentina, Brazil, Chile, Colombia, Spain, and Turkey.

Methods: This was an observational, cross-sectional analysis of samples from patients with suspected AATD from March 2018 to January 2022. Read More

View Article and Full-Text PDF

Bronchiectasis in patients with antineutrophil cytoplasmic antibody-associated vasculitis: a case control study on clinical features and prognosis.

Expert Rev Respir Med 2022 Jun 16:1-9. Epub 2022 Jun 16.

Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, Haidian, China.

Background: Bronchiectasis was reported in 2%-40% of patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV), but there were no studies on the prevalence, risk factors and impact of AAV-associated bronchiectasis in Chinese patients.

Research Design And Methods: AAV patients were retrospectively enrolled. The clinical, laboratory and imaging features and the prognosis were analyzed and compared between those with and without bronchiectasis. Read More

View Article and Full-Text PDF

Chronic bronchiectasis complicated with benign jejuno-ileal pneumatosis intestinalis.

Respirol Case Rep 2022 Jul 7;10(7):e0985. Epub 2022 Jun 7.

Division of Chest Medicine, Department of Internal Medicine National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan Taiwan.

Patients with chronic bronchiectasis are susceptible to various respiratory complications. In this report, however, we describe a 53-year-old male with chronic bronchiectasis who developed extensive but asymptomatic jejuno-ileal pneumatosis intestinalis. The patient did not have preceding pneumothorax or pneumomediastinum, and he did not receive cytotoxic or immunosuppressive therapy. Read More

View Article and Full-Text PDF