47,586 results match your criteria Bronchi


Oxidative and nitrosative stress involvement in the pathogenesis of obstructive lung diseases of increasing severity.

Curr Med Chem 2020 Jun 4. Epub 2020 Jun 4.

Dipartimento di Scienze Cliniche e Biologiche, AOU, San Luigi, Orbassano, Università di Torino, Torino. Italy.

The imbalance between increased oxidative agents and antioxidant defence mechanisms is central in the pathogenesis of obstructive lung diseases such as asthma and COPD. In these patients, there are increased levels of reactive oxygen species. Superoxide anions (O2 - ), hydrogen peroxide (H2O2) and hydroxyl radicals (. Read More

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http://dx.doi.org/10.2174/0929867327666200604165451DOI Listing

Video-assisted thoracoscopic right upper lobectomy in a patient with a displaced bronchus and vascular abnormalities.

Asian J Endosc Surg 2020 Jun 3. Epub 2020 Jun 3.

Department of Thoracic Surgery, Center Hospital of the National Center for Global Health and Medicine, Tokyo, Japan.

Bronchial abnormalities are rare, and they are infrequently associated with pulmonary vascular abnormalities. It is important to identify such abnormal anatomical structures before lobectomy of the lung under thoracoscopy. There have been only three reports on video-assisted thoracoscopic lobectomy in patients with anomalous bronchi and vascular abnormalities to date. Read More

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http://dx.doi.org/10.1111/ases.12819DOI Listing

Two-Way: A Novel Method for Identifying the Anatomy During Uniportal Thoracoscopic Segmentectomy.

Ann Thorac Surg 2020 May 31. Epub 2020 May 31.

Department of Thoracic Surgery, the Third Affiliated Hospital of Kunming Medical University, Kunming, 650105, China.

Owing to the fact that the segmental bronchi and vessels are commonly variable and complicated, it is difficult to correctly identify them. Misidentification of the segmental anatomy could result in the failure of segmentectomy and conversion to the other surgical procedures (such as bisegmentectomy or lobectomy). As a result, we summarized a novel method to identify the target segmental vessels and bronchi by exposing the adjacent segmental anatomy during uniportal video-assisted thoracoscopic (VATS) segmentectomy, which could help to reduce the chance of misidentification. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.04.041DOI Listing

Bile in bronchi: A case report.

Respir Med Case Rep 2020 20;30:101075. Epub 2020 May 20.

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, People's Republic of China.

Background: The biliary bronchial fistula is rare and difficult to treat. Here we report a 49-year-old woman diagnosed with biliary bronchial fistula due to cough with yellow-green sputum.

Case Presentation: this is a typical case of the biliary bronchial fistula with typical symptoms. Read More

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http://dx.doi.org/10.1016/j.rmcr.2020.101075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260606PMC

Stenotrophomonas maltophilia Infection in a Patient with Acute Exacerbation of Chronic Obstructive Pulmonary Disease (COPD): A Colonizer or True Infection?

Am J Case Rep 2020 Jun 2;21:e924577. Epub 2020 Jun 2.

Department of Internal Medicine, Reading Hospital, Tower Health System, Reading, PA, USA.

BACKGROUND This article describes a finding of sputum culture positive for Stenotrophomonas maltophilia in an elderly woman with past medical history of chronic obstructive pulmonary disease (COPD) and hypertension, presenting with acute hypoxemic hypercapnic respiratory failure secondary to COPD exacerbation from bronchitis/bronchopneumonia. CASE REPORT Computed tomography (CT) of the chest showed secretions in the lower lobe bronchi and small scattered clustered nodules consistent with bronchitis/mild bronchopneumonia without evidence of pulmonary embolism. A sputum culture was positive for Stenotrophomonas maltophilia. Read More

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http://dx.doi.org/10.12659/AJCR.924577DOI Listing

Bruton's tyrosine kinase inhibition effectively protects against human IgE-mediated anaphylaxis.

J Clin Invest 2020 Jun 2. Epub 2020 Jun 2.

Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, United States of America.

No known therapies can prevent anaphylaxis. Bruton's tyrosine kinase (BTK) is an enzyme thought to be essential for high-affinity IgE receptor (FcεRI) signaling in human cells. We tested the hypothesis that FDA-approved BTK inhibitors (BTKi's) would prevent IgE-mediated responses including anaphylaxis. Read More

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http://dx.doi.org/10.1172/JCI138448DOI Listing

Single Y-shaped tracheal self-expandable metallic stent for emergent carinal stenosis combined with stenosis of the right main and intermediate bronchi.

Medicine (Baltimore) 2020 May;99(22):e20498

Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, No. 1, East Jianshe Rd, Zhengzhou, Henan Province.

To explore the outcome of placing a single Y-shaped tracheal self-expandable metallic stent (SEMS) to treat emergent carinal stenosis combined with stenosis of the right main and intermediate bronchi.The clinical and imaging data of 10 patients (8 males, 2 females) with carinal stenosis combined with stenosis of the right main and intermediate bronchi were retrospectively analyzed. There were 4 patients with esophageal cancer and 6 patients with lung cancer. Read More

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http://dx.doi.org/10.1097/MD.0000000000020498DOI Listing

Traction Bronchiectasis/Bronchiolectasis is Associated with Interstitial Lung Abnormality Mortality.

Eur J Radiol 2020 May 18;129:109073. Epub 2020 May 18.

Center for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

Purpose: To investigate if the presence and severity of traction bronchiectasis/bronchiolectasis are associated with poorer survival in subjects with ILA.

Method: The study included 3,594 subjects (378 subjects with ILA and 3,216 subjects without ILA) in AGES-Reykjavik Study. Chest CT scans of 378 subjects with ILA were evaluated for traction bronchiectasis/bronchiolectasis, defined as dilatation of bronchi/bronchioles within areas demonstrating ILA. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109073DOI Listing

Quantitative CT-based structural alterations of segmental airways in cement dust-exposed subjects.

Respir Res 2020 May 29;21(1):133. Epub 2020 May 29.

School of Mechanical Engineering, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, South Korea.

Background: Dust exposure has been reported as a risk factor of pulmonary disease, leading to alterations of segmental airways and parenchymal lungs. This study aims to investigate alterations of quantitative computed tomography (QCT)-based airway structural and functional metrics due to cement-dust exposure.

Methods: To reduce confounding factors, subjects with normal spirometry without fibrosis, asthma and pneumonia histories were only selected, and a propensity score matching was applied to match age, sex, height, smoking status, and pack-years. Read More

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http://dx.doi.org/10.1186/s12931-020-01399-9DOI Listing

Molecular Detection of SARS-CoV-2 Infection in FFPE Samples and Histopathologic Findings in Fatal SARS-CoV-2 Cases.

Am J Clin Pathol 2020 May 26. Epub 2020 May 26.

Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH.

Objectives: To report methods and findings of 2 autopsies with molecular evaluation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) positive individuals.

Methods: Postmortem examination was completed following Centers for Disease Control and Prevention public guidelines. Numerous formalin-fixed paraffin-embedded (FFPE) tissue types from each case were surveyed for SARS-CoV-2 RNA by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Read More

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http://dx.doi.org/10.1093/ajcp/aqaa091DOI Listing

The pulmonary sequalae in discharged patients with COVID-19: a short-term observational study.

Respir Res 2020 May 24;21(1):125. Epub 2020 May 24.

Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue No.1277, Wuhan, 430022, China.

Background: A cluster of patients with coronavirus disease 2019 (COVID-19) pneumonia were discharged from hospitals in Wuhan, China. We aimed to determine the cumulative percentage of complete radiological resolution at each time point, to explore the relevant affecting factors, and to describe the chest CT findings at different time points after hospital discharge.

Methods: Patients with COVID-19 pneumonia confirmed by RT-PCR who were discharged consecutively from the hospital between 5 February 2020 and 10 March 2020 and who underwent serial chest CT scans on schedule were enrolled. Read More

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http://dx.doi.org/10.1186/s12931-020-01385-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245637PMC

[Effect of acupuncture and moxibustion at "Feishu"Dazhui"and "Fengmen"on the expression of CC chemokine ligand 1 and CC chemokine receptor 8 in lung tissue of rats with asthma].

Zhen Ci Yan Jiu 2020 May;45(5):363-7

The Third Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450008, China.

Objective: To investigate the protein expression of CC chemokine ligand 1 (CCL1) and CC chemokine receptor 8 (CCR8) in the lung tissue of rats and the mechanism of acupuncture and moxibustion at "Feishu"(BL13), "Dazhui" (GV14) and "Fengmen"(BL12) in the treatment of asthma.

Methods: Sprague-Dawley rats were randomly divided into blank, model, acupuncture and moxibustion groups,=10 in each group. Ovalbumin sensitization via intraperitoneal injection was performed to establish a model of asthma. Read More

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http://dx.doi.org/10.13702/j.1000-0607.190394DOI Listing

Neonatal pulmonary sequestration (PS) with rhabdomyomas-like hyperplasia: A case report.

Medicine (Baltimore) 2020 May;99(20):e20052

Children's Hospital of Capital Medical University, Beijing, China.

Introduction: Pulmonary sequestration (PS) is a rare pulmonary congenital malformation characterized by disconnection with the tracheobronchial tree or the pulmonary arterial blood supply thus impeding the connection to the arterial blood supply from systemic circulation, ultimately resulting in a non-functional lung.

Patient Concerns: A 73-day-old boy with rhabdomyomatoid hyperplasia was hospitalized for cough and fever 2 months after birth.

Diagnoses: Routine B-ultrasound revealed a cystic malformation in the right lung. Read More

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http://dx.doi.org/10.1097/MD.0000000000020052DOI Listing

Early manifestation of ARDS in COVID-19 infection in a 51- year-old man affected by Mounier-Kuhn Syndrome.

Heart Lung 2020 May 16. Epub 2020 May 16.

Nephrology and Urology Research Center, Baqiyatallah University of Medical Sciences, Tehran.

We present the first patient of a 51-year-old man with fever, dyspnea and deterioration of his chronic coughs, who was referred to the Mounier-Kuhn syndrome (MKS). Chest computed tomography (CT) scan revealed increased diameter of his trachea (39 mm), right (30 mm) and left (26 mm) main bronchi, because of MKS. Then, COIVD-19 infection was eventually confirmed by RT-PCR. Read More

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http://dx.doi.org/10.1016/j.hrtlng.2020.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229908PMC

Targeted lung denervation in sheep: durability of denervation and long-term histologic effects on bronchial wall and peribronchial structures.

Respir Res 2020 May 18;21(1):117. Epub 2020 May 18.

Nuvaira, Inc, Suite 105 3750 Annapolis Lane North, Minneapolis, MN, 55447, USA.

Background: Targeted lung denervation (TLD), a novel bronchoscopic procedure which attenuates pulmonary nerve input to the lung to reduce the clinical consequences of neural hyperactivity, may be an important emerging treatment for COPD. While procedural safety and impact on clinical outcomes have recently been reported, the mechanism of action has not been reported. We explored the long-term pathologic and histopathologic effects in a sheep model of ablation of bronchial branches of the vagus nerve using a novel dual-cooled radiofrequency ablation catheter. Read More

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http://dx.doi.org/10.1186/s12931-020-01383-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236341PMC

First report of the use of mucosal swabs of the palatine tonsillar crypt for detection of in naturally infected calves.

N Z Vet J 2020 May 18:1-7. Epub 2020 May 18.

Diagnostic and Surveillance Services, Biosecurity New Zealand, NZ Ministry for Primary Industries, 66 Ward Street PO Box 40742, New Zealand.

Aims: To compare detection by real-time PCR of DNA from on mucosal swabs taken from the palatine tonsillar crypt and the mainstem bronchi of clinically asymptomatic calves after slaughter.

Methods: We compared the sensitivity of mucosal swabs taken from two sites: the palatine tonsillar crypt and the mainstem bronchi. Paired samples were taken post-mortem at slaughter from 55 clinically well calves from an infected herd and were tested by real-time PCR for the presence of -specific DNA. Read More

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http://dx.doi.org/10.1080/00480169.2020.1765892DOI Listing

A case of congenital bronchial atresia patient with subclinical infection who underwent lung resection.

Respir Med Case Rep 2020 6;30:101076. Epub 2020 May 6.

Department of Respiratory Medicine, Tokyo Saiseikai Central Hospital, Japan.

Congenital bronchial atresia, CBA, is rare and has often asymptomatic benign condition. The CBA condition usually arose during the formation of bronchi, but the CBA patients are able to live well into adulthood. This case highlights a potential surgical intervention for a CBA patient with subclinical infection. Read More

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http://dx.doi.org/10.1016/j.rmcr.2020.101076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218211PMC

Secondary Carina and Lobar Bronchi Stenting in Patients with Advanced Lung Cancer: Is It Worth the Effort? A Clinical Experience.

Ann Thorac Cardiovasc Surg 2020 May 18. Epub 2020 May 18.

Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo, Italy.

Background: The lobar airway stenting remains an endoscopic procedure not well standardized in patients with locally advanced lung cancer disease. The goal of this study was to evaluate technical feasibility, clinical outcome, and complications of different stents in patients with malignant lesions involving lobar bronchi, primary and secondary carina.

Methods: Between November 2008 and October 2013, we retrospectively analyzed 146 patients with benign and malignant tracheobronchial stenosis who underwent airway stent insertion below main carina and main bronchi. Read More

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http://dx.doi.org/10.5761/atcs.oa.19-00040DOI Listing

Ectopic origin of bronchial arteries: still a potential pitfall in embolization.

Surg Radiol Anat 2020 May 15. Epub 2020 May 15.

Department of Internal Medicine, Fuji City General Hospital, 50 Takashimacho, Fuji-shi, Shizuoka, 417-8567, Japan.

Purpose: To evaluate the influence of ectopic origin of bronchial arteries (BAs) on bronchial artery embolization (BAE) for hemoptysis.

Methods: CT and angiography images of 50 consecutive sessions in 39 patients (aged 26-93 years; mean, 70.6 years) who underwent BAE for hemoptysis from April 2010 to December 2019 were reviewed. Read More

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http://dx.doi.org/10.1007/s00276-020-02495-7DOI Listing

Psittacid herpesvirus 3 infection in rose-ringed parakeets in southern Brazil.

J Vet Diagn Invest 2020 May;32(3):409-412

Departments of Preventive Veterinary Medicine (Murer, Ribeiro, Cargnelutti, Lovato) and Pathology (Kommers), Virology Section (Flores), Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil.

We diagnosed disease caused by psittacid herpesvirus 3 (PsHV-3), a novel psittacid pathogen, in rose-ringed parakeets () housed in an exotic psittacine breeding colony in southern Brazil. The disease affected several adult birds. Clinical signs included apathy, tachypnea, and wheezing. Read More

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http://dx.doi.org/10.1177/1040638720913075DOI Listing

[Dynamic changes of chest CT imaging in patients with COVID-19].

Zhejiang Da Xue Xue Bao Yi Xue Ban 2020 May;49(2):191-197

Radiology Department, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.

Objective: To analyze the dynamic changes of chest CT images of patients with coronavirus disease 2019 (COVID-19).

Methods: Fifty-two cases of COVID-19 were admitted in the First Affiliated Hospital of Zhejiang University School of Medicine. The consecutive chest CT scans were followed up for all patients with an average of 4 scans performed per patient during the hospitalization. Read More

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Could nasal nitric oxide help to mitigate the severity of COVID-19?

Microbes Infect 2020 May 6. Epub 2020 May 6.

Center for Molecular and Clinical Immunology, Chang Gung University, Taoyuan, Taiwan; Chang Gung Immunology Consortium, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Department of Biomedical Sciences, University of the Pacific, Arthur Dugoni School of Dentistry, San Francisco, CA, USA; University of Paris, Paris, France. Electronic address:

The nasal cavity and turbinates play important physiological functions by filtering, warming and humidifying inhaled air. Paranasal sinuses continually produce nitric oxide (NO), a reactive oxygen species that diffuses to the bronchi and lungs to produce bronchodilatory and vasodilatory effects. Studies indicate that NO may also help to reduce respiratory tract infection by inactivating viruses and inhibiting their replication in epithelial cells. Read More

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http://dx.doi.org/10.1016/j.micinf.2020.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200356PMC
May 2020
2.861 Impact Factor

Maldevelopment of intrapulmonary bronchial cartilage in congenital diaphragmatic hernia.

Pediatr Pulmonol 2020 May 5. Epub 2020 May 5.

Department of Pathology and Applied Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine (KPUM), Kyoto, Japan.

Background: Pulmonary hypoplasia is an important cause of morbidity and mortality in infants with congenital diaphragmatic hernia (CDH). This study aimed to verify our hypothesis that the abnormal development of bronchial cartilage as well as alveolar immaturity, might play a central role in hypoplasia of the lung in human CDH.

Method: We retrospectively analyzed autopsied lungs from 10 CDH cases and compared with nine age-matched controls to assess the bronchial cartilage and alveolar maturity using morphological techniques. Read More

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http://dx.doi.org/10.1002/ppul.24799DOI Listing

A diver's dilemma - a case report on bronchopulmonary sequestration.

BMC Pulm Med 2020 May 4;20(1):121. Epub 2020 May 4.

Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore, Singapore.

Background: An asymptomatic SCUBA (Self-contained underwater breathing apparatus) diver was discovered to have an intralobar bronchopulmonary sequestration during routine pre-course screening. This is the first reported case of a diver who, having previously completed several recreational and military diving courses, was subsequently diagnosed with a congenital lung condition, possibly contraindicating diving. Presently, there is no available literature providing guidance on the diving fitness of patients with such a condition. Read More

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http://dx.doi.org/10.1186/s12890-020-1159-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199314PMC

Characterization of ABC Transporters in EpiAirway™, a Cellular Model of Normal Human Bronchial Epithelium.

Int J Mol Sci 2020 Apr 30;21(9). Epub 2020 Apr 30.

Laboratory of General Pathology, Department of Medicine and Surgery, University of Parma, Via Volturno, 39, 43125 Parma, Italy.

The ATP-binding cassette (ABC) transporters P-glycoprotein (MDR1/), multidrug resistance-associated protein 1 (MRP1/), and breast cancer resistance protein (BCRP/) play a crucial role in the translocation of a broad range of drugs; data about their expression and activity in lung tissue are controversial. Here, we address their expression, localization and function in EpiAirway™, a three-dimensional (3D)-model of human airways; Calu-3 cells, a representative in vitro model of bronchial epithelium, are used for comparison. Transporter expression has been evaluated with RT-qPCR and Western blot, the localization with immunocytochemistry, and the activity by measuring the apical-to-basolateral and basolateral-to-apical fluxes of specific substrates in the presence of inhibitors. Read More

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http://dx.doi.org/10.3390/ijms21093190DOI Listing

Towards a Quantitative Mechanistic Understanding of Localized Pulmonary Tissue Retention-A Combined In Vivo/In Silico Approach Based on Four Model Drugs.

Pharmaceutics 2020 Apr 29;12(5). Epub 2020 Apr 29.

Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.

Increasing affinity to lung tissue is an important strategy to achieve pulmonary retention and to prolong the duration of effect in the lung. As the lung is a very heterogeneous organ, differences in structure and blood flow may influence local pulmonary disposition. Here, a novel lung preparation technique was employed to investigate regional lung distribution of four drugs (salmeterol, fluticasone propionate, linezolid, and indomethacin) after intravenous administration in rats. Read More

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http://dx.doi.org/10.3390/pharmaceutics12050408DOI Listing

Inhaled aerosol dose distribution between proximal bronchi and lung periphery.

Eur J Pharm Biopharm 2020 Apr 30. Epub 2020 Apr 30.

Imperial College London, United Kingdom. Electronic address:

Modern inhaled drug discovery programs assess dose delivery to proximal and distal airways using rudimentary imaging indices, where relative deposition is estimated by generically defined 'central' and 'peripheral' lung regions. Utilizing recent data linking the proximal airway topology to a characteristic pattern of aerosol lung deposition, we provide a direct measure of dose distribution between the proximal bronchi and the distal lung. We analyzed scintigraphic lung images of twelve asthma patients following inhalation of 1. Read More

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http://dx.doi.org/10.1016/j.ejpb.2020.04.019DOI Listing

Necrotizing Tracheobronchitis Caused by Aspergillus fumigatus in a Cow.

J Comp Pathol 2020 Apr 15;176:165-169. Epub 2020 Apr 15.

Animal Pathology Laboratory, Santa Catarina State University, Av. Luís de Camões, Conta Dinheiro, Lages, Brazil. Electronic address:

This report describes a case of tracheobronchitis caused by Aspergillus fumigatus in a cow. A 4-year-old Jersey cow was submitted for necropsy examination. Grossly, the mucosa of the trachea and bronchi was diffusely reddened and was covered by a moderate amount of yellow, caseous material, sometimes with small foci of grey 'cotton-like' appearance, suggestive of filamentous fungus. Read More

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http://dx.doi.org/10.1016/j.jcpa.2020.03.005DOI Listing

Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin.

Am J Physiol Lung Cell Mol Physiol 2020 Jun 29;318(6):L1270-L1279. Epub 2020 Apr 29.

Department of Medical Biochemistry, University of Gothenburg, Gothenburg, Sweden.

The organization of the normal airway mucus system differs in small experimental animals from that in humans and large mammals. To address normal murine airway mucociliary clearance, Alcian blue-stained mucus transport was measured ex vivo on tracheal tissues of naïve C57BL/6, , , and EGFP-tagged Muc5b reporter mice. Close to the larynx with a few submucosal glands, the mucus appeared as thick bundles. Read More

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http://dx.doi.org/10.1152/ajplung.00485.2019DOI Listing

An atypical complicated left-sided bronchopleural fistula presenting more than seven months after lobectomy.

Respir Med Case Rep 2020 19;30:101056. Epub 2020 Apr 19.

University of Central Florida, School of Medicine, 6850 Lake Nona Blvd, Orlando, FL, 32827, USA.

Background: Bronchopleural fistulas (BPF) are abnormal sinus tracts connecting the bronchi and pleural cavity and form after surgical resection of a lung lobe. It is a complication with potentially disastrous sequelae including, failure of the bronchial stump to heal, ischemia of the affected area, and/or infection of the stump. Bronchopleural fistulas caused by surgical intervention most commonly present on the right side and within 7-12 days post-operatively, i. Read More

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http://dx.doi.org/10.1016/j.rmcr.2020.101056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183224PMC

Retrievable covered metallic segmented Y airway stent for gastrorespiratory fistula of carina or main bronchi.

J Thorac Cardiovasc Surg 2020 Mar 19. Epub 2020 Mar 19.

Department of Interventional Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Radiology, Ruijin Hospital Luwan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:

Objective: To evaluate the feasibility of new retrievable covered metallic segmented Y airway stents modified with 3-dimensional (3D) printing for gastrorespiratory fistula involving carina or main bronchi.

Methods: We designed a new retrievable covered metallic segmented Y airway stent to fit the anatomical characteristics of the carina region in individual patients. All stents were individually customized based on a 3D-printed mold. Read More

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http://dx.doi.org/10.1016/j.jtcvs.2020.03.019DOI Listing

Intravenous Enzyme Replacement Therapy in Mucopolysaccharidoses: Clinical Effectiveness and Limitations.

Int J Mol Sci 2020 Apr 23;21(8). Epub 2020 Apr 23.

Division of Metabolic Disease, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.

The aim of this review is to summarize the evidence on efficacy, effectiveness and safety of intravenous enzyme replacement therapy (ERT) available for mucopolysaccharidoses (MPSs) I, II, IVA, VI and VII, gained in phase III clinical trials and in observational post-approval studies. Post-marketing data are sometimes conflicting or controversial, possibly depending on disease severity, differently involved organs, age at starting treatment, and development of anti-drug antibodies (ADAs). There is general agreement that ERT is effective in reducing urinary glycosaminoglycans and liver and spleen volume, while heart and joints outcomes are variable in different studies. Read More

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http://dx.doi.org/10.3390/ijms21082975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215308PMC

Gender and Regional Differences in Lung Cancer Mortality in Brazil.

Asian Pac J Cancer Prev 2020 Apr 1;21(4):919-926. Epub 2020 Apr 1.

Federal University of Rio Grande do Norte, Department of Collective Health, Natal, Brazil.

Background And Objective: This was a population-based ecological with data of deaths from the Mortality Information System. The objective of this study was to analyze the temporal trends of mortality induced by bronchi and lung cancer in Brazil and its geographical regions between 2001 and 2015 and secondly to calculate predictions for 2016-2030.

Material And Methods: The mortality trends were analyzed by the Joinpoint regression and calculation of predictions was used the Nordpred software. Read More

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http://dx.doi.org/10.31557/APJCP.2020.21.4.919DOI Listing

Respiratory motion-resolved four-dimensional zero echo time (4D ZTE) lung MRI using retrospective soft gating: feasibility and image quality compared with 3D ZTE.

Eur Radiol 2020 Apr 24. Epub 2020 Apr 24.

Applied Science Lab, GE Healthcare, Menlo Park, CA, USA.

Objectives: To evaluate the feasibility and image quality of respiratory motion-resolved 4D zero echo time (ZTE) lung MRI compared with that of 3D ZTE.

Methods: Our institutional review board approved this study. Twenty-one patients underwent lung scans using 3D ZTE and 4D ZTE sequences via prospective and retrospective soft gating techniques, respectively. Read More

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http://dx.doi.org/10.1007/s00330-020-06890-xDOI Listing

Successful treatment of pyopneumothorax with bronchopleural fistula using endobronchial Watanabe spigots.

Respirol Case Rep 2020 Jul 18;8(5):e00562. Epub 2020 Apr 18.

Division of Respiratory Medicine, Department of Internal Medicine Sarawak General Hospital Kuching Sarawak Malaysia.

Bronchopleural fistula (BPF) can complicate necrotizing pneumonia. Surgery would be indicated in patients who fail conservative management, yet this group is often of poor pulmonary function and general condition. Bronchial occlusion with endobronchial Watanabe spigots (EWS) can be a potential alternative treatment when the culprit bronchi can be isolated. Read More

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http://dx.doi.org/10.1002/rcr2.562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165361PMC

Case report of endoprosthesis -Y implantation in severe respiratory failure in the MPSII patient; comparison with literature data.

BMC Pulm Med 2020 Apr 20;20(1):99. Epub 2020 Apr 20.

Clinical Department of Metabolic Diseases, University Hospital, Krakow, Poland.

Background: The tracheobronchomalacia is a life-threatening complication of mucopolysaccharidosis (MPS) without known effective, optimal treatment. The severe expiratory collapse of the trachea and bronchi is one of causes of the high rate of deaths in the course of airway impairment in MPSII patients.

Case Presentation: Due to the adynamic tracheobronchomalacia despite of enzymatic treatment (ERT) in our MPSII patient, a life-saving tracheal bifurcated type-Y endoprosthesis (a self-expanding, metal stent for the prosthesis of tracheal and bronchial stenosis) was implanted. Read More

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http://dx.doi.org/10.1186/s12890-020-1143-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7171830PMC

Application of preoperative embolization during surgery for the destroyed lung.

Ann Palliat Med 2020 Apr 18. Epub 2020 Apr 18.

Department of Radiology, Shanghai Pulmonary Hospital, Tongji University, School of Medicine, Shanghai 200433, China.

Background: The destroyed lung has been a challenge in the clinical practice of thoracic surgery, and severe adhesions and massive bleeding during surgery are the main obstacles faced by surgeons. This study aimed to investigate the efficacy of the preoperative embolization of blood vessels in adhesions during surgery for the destroyed lung.

Methods: A total of 7 patients underwent preoperative embolization for lung resection of destroyed lungs between June 2016 and February 2019. Read More

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http://dx.doi.org/10.21037/apm.2020.04.02DOI Listing

Predicting Pathological Invasiveness of Lung Adenocarcinoma Manifesting as GGO-Predominant Nodules: A Combined Prediction Model Generated From DECT.

Acad Radiol 2020 Apr 14. Epub 2020 Apr 14.

Department of Radiology, The Third Affiliated Hospital of Soochow University, No.185, Juqian Street, Changzhou 213003, Jiangsu, China. Electronic address:

Rationale And Objectives: To evaluate qualitative and quantitative indicators generated from Dual-energy computed tomography (DECT) for preoperatively differentiating between invasive adenocarcinoma (IAC) and preinvasive or minimally invasive adenocarcinoma (MIA) lesions manifesting as ground-glass opacity-predominant (GGO-predominant) nodules.

Materials And Methods: We retrospectively enrolled 143 cases of completely resected GGO-predominant lung adenocarcinoma with DECT examinations between December 2017 and July 2019. Qualitative and quantitative parameters of GGO-predominant nodules were compared after grouping nodules into IAC and preinvasive-MIA groups. Read More

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http://dx.doi.org/10.1016/j.acra.2020.03.007DOI Listing

Intrapulmonary airway smooth muscle is hyperreactive with a distinct proteome in asthma.

Eur Respir J 2020 Apr 16. Epub 2020 Apr 16.

Department of Medicine, McGill University, Montreal, Quebec, Canada.

Constriction of airways during asthmatic exacerbation is the result of airway smooth muscle (ASM) contraction. Although it is generally accepted that ASM is hypercontractile in asthma, this has not been unambiguously demonstrated. Whether airway hyperresponsiveness is the result of increased ASM mass alone or also increased contractile force generation per unit of muscle directly determines the potential avenues for treatment. Read More

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http://dx.doi.org/10.1183/13993003.02178-2019DOI Listing

Role of epoxyeicosatrienoic acids in the lung.

Prostaglandins Other Lipid Mediat 2020 Apr 12;149:106451. Epub 2020 Apr 12.

Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ap. Postal 70-228, Ciudad de México, México. Electronic address:

Epoxyeicosatrienoic acids (EETs) are synthetized from arachidonic acid by the action of members of the CYP2C and CYP2J subfamilies of cytochrome P450 (CYPs). The effects of EETs on cardiovascular function, the nervous system, the kidney and metabolic disease have been reviewed. In the lungs, the presence of these CYPs and EETs has been documented. Read More

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http://dx.doi.org/10.1016/j.prostaglandins.2020.106451DOI Listing

The bronchial tree of the human embryo: an analysis of variations in the bronchial segments.

J Anat 2020 Apr 13. Epub 2020 Apr 13.

Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

A classical study has revealed the general growth of the bronchial tree and its variations up to Carnegie stage (CS) 19. In the present study, we extended the morphological analysis CS by CS until the end of the embryonic period (CS23). A total of 48 samples between CS15 and CS23 belonging to the Kyoto Collection were used to acquire imaging data by performing phase-contrast X-ray computed tomography. Read More

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http://dx.doi.org/10.1111/joa.13199DOI Listing

CYP2A13 Acts as the Main Metabolic CYP450s Enzyme for Activating Leonurine in Human Bronchial Epithelial Cells.

Med Sci Monit 2020 Apr 14;26:e922149. Epub 2020 Apr 14.

School of Nursing, Nanjing Medical University, Nanjing, Jiangsu, China (mainland).

BACKGROUND Leonurine is an active component of the traditional Chinese medicine Leonurus japonicus. This study aimed to investigate the effects of overexpressed CYP450s on the metabolic activity of leonurine. MATERIAL AND METHODS BEAS-2B cells stably expressing CYP1A1, 1A2, 2A13, 2B6, and 3A4 were constructed. Read More

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http://dx.doi.org/10.12659/MSM.922149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7174896PMC

Improved Early Recognition of Coronavirus Disease-2019 (COVID-19): Single-Center Data from a Shanghai Screening Hospital.

Arch Iran Med 2020 04 1;23(4):272-276. Epub 2020 Apr 1.

Department of Respiratory Medicine, Zhoupu Hospital affiliated to Shanghai University of Medicine and Health Sciences, Shanghai, China. No. 1500 Zhouyuan Road, Pudong new District, Shanghai 201318, China.

Background: In December 2019, an outbreak of a novel coronavirus disease (COVID-19; previously known as 2019-nCoV) was reported in Wuhan, Hubei province, China, which has subsequently affected more than 200 countries worldwide including Europe, North America, Oceania, Africa and other places. The number of infected people is rapidly increasing, while the diagnostic method of COVID-19 is only by nucleic acid testing.

Objective: To explain the epidemiological characteristics, clinical features, imaging manifestations and to judge diagnostic value of COVID-19 by analyzing the clinical data of COVID-19 suspected and confirmed patients in a non-outbreak, Shanghai, China. Read More

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http://dx.doi.org/10.34172/aim.2020.10DOI Listing

The Heart, Bronchi, and Bronchial Vessels Commentary on The Heart, Bronchi, and Bronchial Vessels.

Acad Med 2020 Apr 7. Epub 2020 Apr 7.

R.B. Gunderman is chancellor's professor, Indiana University School of Medicine, Indianapolis, Indiana; email:

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http://dx.doi.org/10.1097/ACM.0000000000003380DOI Listing

Radiography and computed tomography of the heart and lower respiratory tract in toco toucans (Ramphastos toco).

Anat Histol Embryol 2020 Apr 7. Epub 2020 Apr 7.

Department of Animal Reproduction and Veterinary Radiology, School of Veterinary Medicine and Animal Science, São Paulo State University (Unesp), Botucatu, Brazil.

This study aimed to evaluate normal features of the heart and lower respiratory tract in toco toucans by means of radiography and helical computed tomography (CT) scanner. Fifteen healthy adult toco toucans (Ramphastos toco), 10 females and 5 males, average body mass of 650 g were studied. CT examination as well as right lateral and ventrodorsal radiographic examinations of the coelomic cavity were performed under chemical restraint. Read More

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http://dx.doi.org/10.1111/ahe.12559DOI Listing

Bronchoscopic Treatment of Airway Obstructions With a Novel Electrosurgical Device.

J Bronchology Interv Pulmonol 2020 Apr 6. Epub 2020 Apr 6.

Department of Medicine, Division of Pulmonary and Critical Care, University of California, San Francisco.

Objectives: Airway obstructions (AOs) in the central airway or lobar bronchi develop due to malignant or benign disease. Because of the morbidity and mortality associated with AO, it is important to develop additional therapeutic ablative techniques. CoreCath2. Read More

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http://dx.doi.org/10.1097/LBR.0000000000000675DOI Listing