46,434 results match your criteria Bronchi


Generation of lung organoids from human pluripotent stem cells in vitro.

Nat Protoc 2019 Jan 21. Epub 2019 Jan 21.

Program in Cell and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI, USA.

The lung epithelium is derived from the endodermal germ layer, which undergoes a complex series of endoderm-mesoderm-mediated signaling events to generate the final arborized network of conducting airways (bronchi, bronchioles) and gas-exchanging units (alveoli). These stages include endoderm induction, anterior-posterior and dorsal-ventral patterning, lung specification, lung budding, branching morphogenesis, and, finally, maturation. Here we describe a protocol that recapitulates several of these milestones in order to differentiate human pluripotent stem cells (hPSCs) into ventral-anterior foregut spheroids and further into two distinct types of organoids: human lung organoids and bud tip progenitor organoids. Read More

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http://dx.doi.org/10.1038/s41596-018-0104-8DOI Listing
January 2019

Sex differences of brain and their implications for personalized therapy.

Pharmacol Res 2019 Jan 16. Epub 2019 Jan 16.

Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123 Brescia, Italy; Interdipartimental University Center of Research "Adaption and Regeneration of Tissues and Organs-(ARTO)", University of Brescia, 25123 Brescia, Italy.

Nowadays, it is known that the sex differences regard many organs, e.g., liver, vessels, pancreas, lungs, bronchi and also the brain. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.030DOI Listing
January 2019

Mouse Models Reveal Role of T-Cytotoxic and T-Reg Cells in Immune Response to Influenza: Implications for Vaccine Design.

Viruses 2019 Jan 11;11(1). Epub 2019 Jan 11.

Burnett School of Biomedical Sciences, University of Central Florida Medical School, Orlando, FL 32816, USA.

Immunopathologic examination of the lungs of mouse models of experimental influenza virus infection provides new insights into the immune response in this disease. First, there is rapidly developing perivascular and peribronchial infiltration of the lung with T-cells. This is followed by invasion of T-cells into the bronchiolar epithelium, and separation of epithelial cells from each other and from the basement membrane leading to defoliation of the bronchial epithelium. Read More

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http://www.mdpi.com/1999-4915/11/1/52
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http://dx.doi.org/10.3390/v11010052DOI Listing
January 2019
3 Reads

Residual airway foreign bodies in children who underwent rigid bronchoscopy.

Int J Pediatr Otorhinolaryngol 2019 Jan 7;118:170-176. Epub 2019 Jan 7.

Department of Cardiothoracic Surgery, Children's Hospital, Zhejiang University School of Medicine, China. Electronic address:

Objective: To analyze the causes of residual airway foreign bodies in children who underwent rigid bronchoscopy in order to improve the success rate of primary surgery.

Methods: Clinical data from 1130 children with airway foreign bodies, including 736 males and 394 females aged 0.42-14 years, who underwent rigid bronchoscopy in our hospital from January 2015 to May 2018 were retrospectively collected and analyzed by cluster sampling. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876193000
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http://dx.doi.org/10.1016/j.ijporl.2019.01.007DOI Listing
January 2019
3 Reads

Palatal rhinosporidiosis: an unusual case report and review of the literature.

J Korean Assoc Oral Maxillofac Surg 2018 Dec 28;44(6):293-297. Epub 2018 Dec 28.

Department of Oral and Maxillofacial Pathology, Institute of Dental Sciences, Rohilkhand University, Bareilly, India.

Rhinosporidiosis is a chronic, granulomatous, mucocutaneous infection caused by Rhinosporidium seeberi . The infection is non-contagious and sporadic in humans. The site most commonly affected is the mucous membrane of the nose and nasopharynx, followed by the oropharynx, trachea, bronchi, ear, eye, and genitourinary tract. Read More

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http://dx.doi.org/10.5125/jkaoms.2018.44.6.293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327010PMC
December 2018

[Clinical analysis of 5 cases of endobronchial hamartoma].

Zhonghua Jie He He Hu Xi Za Zhi 2019 Jan;42(1):15-19

Department of Respiratory and Critical Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China.

To analyze the clinical manifestations of patients with endobronchial hamartoma(EH),and therefore to improve understanding of the disease. Data were retrospectively reviewed to describe the clinical characteristics, diagnosis procedures and prognosis of EH, including 5 patients in Beijing Anzhen Hospital, Capital Medical University from Jun 2007 to Feb 2018 and another 159 patients from Chinese and English literatures published after Jan 2000. The five patients, 4 males and 1 female, aged from 46 to 69 years[mean (56±7) years], were diagnosed with EH in our hospital. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2019.01.006DOI Listing
January 2019

First Evaluation of the Next Generation Endobronchial Ultrasound System in preclinical models.

Ann Thorac Surg 2019 Jan 2. Epub 2019 Jan 2.

Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Ontario, Canada. Electronic address:

Background: The next-generation convex probe endobronchial ultrasound (CP-EBUS) was developed to improve the ease of operation and the acquisition of EBUS skills for new trainees. The aim of this study was to evaluate the changes in the prototype next-generation CP-EBUS compared to the current CP-EBUS.

Methods: The prototype next-generation CP-EBUS, with a decreased forward oblique view, more flexible angulation range, smaller ultrasound probe, and sharper needle angle, was compared with the current CP-EBUS. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00034975183186
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http://dx.doi.org/10.1016/j.athoracsur.2018.11.068DOI Listing
January 2019
2 Reads

In vitro anti-inflammatory effects of AZD8999, a novel bifunctional muscarinic acetylcholine receptor antagonist /β2-adrenoceptor agonist (MABA) compound in neutrophils from COPD patients.

PLoS One 2019 4;14(1):e0210188. Epub 2019 Jan 4.

CIBERES, Health Institute Carlos III, Valencia, Spain.

Recent evidence indicates that AZD8999 (LAS190792), a novel muscarinic acetylcholine receptor antagonist and β2-adrenoceptor agonist (MABA) in development for chronic respiratory diseases, induces potent and sustained relaxant effects in human bronchi by adressing both muscarinic acetylcholine receptors and β2-adrenoceptor. However, the anti-inflammatory effects of the AZD8999 monotherapy or in combination with corticosteroids are unknown. This study investigates the anti-inflammatory effects of AZD8999 in monotherapy and combined with fluticasone propionate in neutrophils from healthy and chronic obstructive pulmonary disease (COPD) patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210188PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319735PMC
January 2019
1 Read

A specific laryngeal finding in dogs with bronchial vegetal foreign bodies: a retrospective study of 63 cases.

J Vet Med Sci 2018 Dec 28. Epub 2018 Dec 28.

Department of Veterinary Medicine, University of Perugia.

Grass awns commonly cause respiratory disease in dogs; when located in the trachea or bronchi, they cause severe bronchial inflammation and sepsis. The interplay of cough, bronchoconstriction, and mucus secretion can result in a less effective expulsive cough phase, especially when the causal factor persists. The bronchial exudate could consequently become trapped in the upper respiratory tracts of dogs with bronchial vegetal foreign bodies. Read More

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http://dx.doi.org/10.1292/jvms.18-0293DOI Listing
December 2018

The anatomic substrate of irreversible airway obstruction and barotrauma in a case of hurricane-triggered fatal status asthmaticus during puerperium: Lessons from an autopsy.

Respir Med Case Rep 2019 21;26:136-141. Epub 2018 Dec 21.

Arkadi M. Rywlin M.D. Department of Pathology and Laboratory Medicine, Mount Sinai Medical Center, Miami Beach, FL, USA.

Non-fully reversible airway obstruction in fatal asthma is often seen in association with profound structural changes of the bronchial wall, termed airway remodeling. Evidence suggests that heavy precipitation events can trigger epidemics of severe asthma. We present a case of fatal asthma in a young woman with no prior near-fatal exacerbations and postulate that the patient's extensive airway remodeling and puerperal state (susceptibility factors), in combination with a massive allergen challenge during a hurricane landfall (triggering factor), played a central role in her death. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22130071183038
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http://dx.doi.org/10.1016/j.rmcr.2018.12.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6306954PMC
December 2018
3 Reads

Influence of omalizumab therapy on airway remodeling assessed with high-resolution computed tomography (HRCT) in severe allergic asthma patients.

Adv Respir Med 2018 Dec 30. Epub 2018 Dec 30.

II Chair of Internal Medicine, Faculty of Medicine, Department of Pulmonology, Jagiellonian University Medical College, Skawińska 8, 31-066 Kraków, Poland.

Introduction: Airway remodeling is an important factor in persistent obstruction in severe asthma. High resolution computed tomography (HRCT) is an effective method of detecting changes in airway structure. Our aim was to use HRCT to assess changes in airway remodeling in patients with severe allergic asthma who are treated with omalizumab. Read More

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http://dx.doi.org/10.5603/ARM.a2018.0046DOI Listing
December 2018
1 Read

Diagnosis, Classification, and Management of Pediatric Tracheobronchomalacia: A Review.

JAMA Otolaryngol Head Neck Surg 2018 Dec 27. Epub 2018 Dec 27.

Department of Surgery, Boston Children's Hospital, Boston, Massachusetts.

Importance: Tracheobronchomalacia (TBM) describes an increased collapsibility of the trachea and bronchi that is greatest on forced expiration. A broad term, TBM encompasses intrinsic tracheal weakness, some forms of tracheal deformation, and extrinsic compression. Tracheobronchomalacia is the most common congenital tracheal anomaly, affecting 1 in 2100 children. Read More

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http://archotol.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaoto.2018.3276DOI Listing
December 2018
4 Reads

Continuous quantitative measurement of the main bronchial dimensions and lung density in the lateral position by four-dimensional dynamic-ventilation CT in smokers and COPD patients.

Int J Chron Obstruct Pulmon Dis 2018 27;13:3845-3856. Epub 2018 Nov 27.

Department of Radiology, Shiga University of Medical Science, Otsu, Shiga 520-2192, Japan.

Purpose: The purpose of this study was to measure changes in lung density and airway dimension in smokers in the lateral position using four-dimensional dynamic-ventilation computed tomography (CT) during free breathing and to evaluate their correlations with spirometric values.

Materials And Methods: Preoperative pleural adhesion assessments included dynamic-ventilation CT of 42 smokers (including 22 patients with COPD) in the lateral position, with the unoperated lung beneath (dependent lung). The scanned lungs' mean lung density (MLD) and the bilateral main bronchi's luminal areas (Ai) were measured automatically (13-18 continuous image frames, 0. Read More

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http://dx.doi.org/10.2147/COPD.S178836DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267741PMC
November 2018

Insertion of a Dumon Y-stent via a permanent tracheostoma without using a rigid bronchoscope.

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Division of General Thoracic Surgery, Department of Surgery, Shiga University of Medical Science, Otsu, Japan.

A 63-year-old man who had received a permanent tracheostoma after oesophageal cancer surgery developed fistulas in the left and right main bronchi and suffered repeated aspiration pneumonia. Placing an indwelling Dumon Y-stent using a rigid bronchoscope is an option to treat fistula and stenosis at the tracheal bifurcation, but in some cases, it may be difficult to use a rigid bronchoscope in patients with a permanent tracheostoma. In this study, we report placing a Dumon Y-stent in a patient with a permanent tracheostoma using a specially modified stent and forceps instead of a rigid bronchoscope. Read More

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http://dx.doi.org/10.1136/bcr-2018-226500DOI Listing
November 2018
1 Read

CHAC1 Is Differentially Expressed in Normal and Cystic Fibrosis Bronchial Epithelial Cells and Regulates the Inflammatory Response Induced by .

Front Immunol 2018 29;9:2823. Epub 2018 Nov 29.

Sorbonne Université, Inserm, Centre de recherche Saint-Antoine (CRSA), Paris, France.

In cystic fibrosis (CF), () colonizes the lungs, leading to chronic inflammation of the bronchial epithelium. ChaC glutathione-specific γ-glutamylcyclotransferase 1 () mRNA is differentially expressed in primary human airway epithelial cells from bronchi (hAECBs) from patients with CF and healthy patients at baseline and upon infection with . CHAC1 degrades glutathione and is associated with ER stress and apoptosis pathways. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282009PMC
November 2018

Effects of cellular differentiation in human primary bronchial epithelial cells: Metabolism of 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone.

Toxicol In Vitro 2019 Mar 13;55:185-194. Epub 2018 Dec 13.

Division of Genetic and Molecular Toxicology, Division of Biochemical Toxicology, National Center for Toxicological Research, U.S Food and Drug Administration, Jefferson, AR 72079, United States. Electronic address:

Many of the toxicants in tobacco smoke undergo biotransformation in the lungs of smokers, both to reactive and to detoxified derivatives. Human air-liquid-interface (ALI) airway tissue models have emerged as an advanced in vitro model for evaluating the toxicity of inhaled substances; however, the metabolic potential of these cultures has not been evaluated extensively. In this study, we compared the metabolic activities of an ALI tissue model to the undifferentiated normal human primary bronchial epithelial (NHBE) cells from which it was derived. Read More

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http://dx.doi.org/10.1016/j.tiv.2018.12.006DOI Listing
March 2019
12 Reads

Does Adenovirus and Coxsackie B Virus Infection Play a Role in Tracheobronchopathia Osteochondroplastica (TO).

Clin Lab 2018 Oct;64(11)

Background: Tracheobronchopathia osteochondroplastica (TO) is a rare benign disease. We report a case of TO. Methods: Chest CT scan and bronchoscope with biopsy was performed for diagnosis and blood tests explored for the latent etiology. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2018.180618DOI Listing
October 2018

Z scores of the fetal trachea and bronchial dimension.

Prenat Diagn 2019 Jan 27;39(1):33-37. Epub 2018 Dec 27.

Department of Ultrasound Diagnosis, The Second Xiangya Hospital of Central South University, Changsha, China.

Objective: To develop Z scores for the trachea and main bronchi in normal fetuses.

Methods: This was a prospective cross-sectional study in 823 normal singleton fetuses. The tracheal diameter immediately proximal to the bifurcation and the left and right main bronchial diameters were measured from their inner to inner edge in the coronal view. Read More

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http://dx.doi.org/10.1002/pd.5394DOI Listing
January 2019
1 Read

Effects of smoking on the lower respiratory tract microbiome in mice.

Respir Res 2018 Dec 14;19(1):253. Epub 2018 Dec 14.

The Center of Experimental Teaching Management, Chongqing Medical University, Chongqing, 401331, China.

Background: Recent studies break with traditional opinion that the lower respiratory tract is sterile, and increasingly focus on the lung microbiome and disease. Smoking, as an important etiology of inflammatory lung disease, was considered as a factor influencing lung microbiome variations in our study, and we aimed to study the effect of smoking on inflammation and microbial diversity and community.

Methods: Forty male mice were selected and randomly divided into a smoking and a non-smoking group. Read More

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https://respiratory-research.biomedcentral.com/articles/10.1
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http://dx.doi.org/10.1186/s12931-018-0959-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295055PMC
December 2018
14 Reads

Comparative study of primary pulmonary cryptococcosis with multiple nodules or masses by CT and pathology.

Exp Ther Med 2018 Dec 17;16(6):4437-4444. Epub 2018 Sep 17.

Department of Respiratory Disease, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, P.R. China.

The manifestations of pulmonary cryptococcosis with multiple nodules or masses on computed tomography (CT) are diverse and difficult to differentiate from those of lung cancer and pulmonary tuberculosis. The present study compared the multislice spiral CT signs with pathological results and used the pathological results to explain the CT signs with the aim of improving the accuracy of the diagnosis of this disease. A retrospective analysis of 20 patients with primary pulmonary cryptococcosis with multiple nodules or masses was performed. Read More

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http://dx.doi.org/10.3892/etm.2018.6745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257807PMC
December 2018

[The computed tomography angiography features of Dieulafoy disease of the bronchus].

Zhonghua Jie He He Hu Xi Za Zhi 2018 Dec;41(12):949-953

Department of Radiology, Peking University People's Hospital, Beijing 100044, China.

To summarize the computed tomography angiography(CTA) features of Dieulafoy disease of the bronchus. The clinical, imaging and pathological data of Dieulafoy disease of the bronchus diagnosed in our hospital from July 4, 2010 to June 20, 2016 were retrospectively analyzed, and the CTA imaging features of the abnormal bronchial arteries were summarized. There were 6 cases of bronchial Dieulafoy disease, 5 males and 1 female, with an average age of (55±15) years. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2018.12.010DOI Listing
December 2018
1 Read

Impact of stainless-steel welding fumes on proteins and non-coding RNAs regulating DNA damage response in the respiratory tract of Sprague-Dawley rats.

J Toxicol Environ Health A 2018 Dec 3:1-15. Epub 2018 Dec 3.

a Department of Biochemistry and Biotechnology, Faculty of Science , Annamalai University , Annamalainagar , TN , India.

Substantial evidence has established the negative impact of inhalation exposure to welding fumes on respiratory functions. The aim of the present study was to investigate the effect of welding fume inhalation on expression of molecules that function as sensors, transducers and effectors of DNA damage response (DDR) in the respiratory tract of male Sprague-Dawley rats. Animals were exposed to 50 mg/m stainless steel welding fumes for 1 h/d for 4, 8, and 12 weeks, respectively. Read More

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http://dx.doi.org/10.1080/15287394.2018.1550027DOI Listing
December 2018
1 Read

Surgical management of non-cystic fibrosis bronchiectasis.

J Thorac Dis 2018 Oct;10(Suppl 28):S3436-S3445

Section of Chest Surgery, Fukujuji Hospital, Tokyo, Japan.

Non-cystic fibrosis bronchiectasis (bronchiectasis) is an abnormal dilatation of the bronchi and bronchioles, resulting from a prolonged recurrent infectious process due to various causes and predisposing factors. This disease has several etiologies and affects a heterogeneous population of patients. The most important viewpoint for the surgical management of bronchiectasis is to select appropriate candidates for surgery and conduct suitable anatomic lung resections at the right time under appropriate conditions. Read More

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http://dx.doi.org/10.21037/jtd.2018.08.128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6218362PMC
October 2018
1 Read

Follow-up outcomes of chronic obstructive pulmonary disease patients who underwent dilatation and curettage with the Karakoca resector balloon: A 188-case series over 5 years.

Medicine (Baltimore) 2018 Nov;97(48):e13400

Medical Park Gaziosmanpaşa Hospital, Istanbul, Turkey.

We previously reported satisfactory results with the Karakoca resector balloon in 10 patients with stage IV chronic obstructive pulmonary disease (COPD) who did not respond to medical treatment. In this article, we present the outcomes of the Karakoca resector balloon dilatation and curettage technique in a larger case series (n = 188).A total of 188 COPD patients [mean age (SD): 69. Read More

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http://Insights.ovid.com/crossref?an=00005792-201811300-0005
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http://dx.doi.org/10.1097/MD.0000000000013400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283145PMC
November 2018
6 Reads

Paediatric and adult bronchiectasis: Monitoring, cross-infection, role of multidisciplinary teams and self-management plans.

Respirology 2019 Feb 30;24(2):115-126. Epub 2018 Nov 30.

Child Health Division, Menzies School of Health Research, Darwin, NT, Australia.

Bronchiectasis is a chronic lung disease associated with structurally abnormal bronchi, clinically manifested by a persistent wet/productive cough, airway infections and recurrent exacerbations. Early identification and treatment of acute exacerbations is an integral part of monitoring and annual review, in both adults and children, to minimize further damage due to infection and inflammation. Common modalities used to monitor disease progression include clinical signs and symptoms, frequency of exacerbations and/or number of hospital admissions, lung function (forced expiratory volume in 1 s (FEV )% predicted), imaging (radiological severity of disease) and sputum microbiology (chronic infection with Pseudomonas aeruginosa). Read More

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http://dx.doi.org/10.1111/resp.13451DOI Listing
February 2019
8 Reads

Competence in bronchial thermoplasty.

Panminerva Med 2018 Nov 27. Epub 2018 Nov 27.

Università degli Studi di Firenze, SOD Pneumologia Interventistica AOUC, Florence, Italy.

Bronchial thermoplasty (BT) is an innovative non-pharmacological endoscopic treatment for patients with severe persistent asthma based on controlled heat release with a device called AlairTM Catheter (Boston Scientific, Natick, MA, USA). The Alair system is the first device that work by delivering radiofrequency or thermal energy to selectively reduce the amount of airway smooth muscle (ASM) in bronchi. Literature showed significant improvement in clinical outcomes such as symptom control, severe exacerbation rate, hospitalization, quality of life, and number of working or school days lost for asthma. Read More

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http://dx.doi.org/10.23736/S0031-0808.18.03582-6DOI Listing
November 2018
10 Reads

Cast of the Right Bronchial Tree.

N Engl J Med 2018 Nov;379(22):2151

University of California, San Francisco, San Francisco, CA

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http://www.nejm.org/doi/10.1056/NEJMicm1806493
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http://dx.doi.org/10.1056/NEJMicm1806493DOI Listing
November 2018
31 Reads

Comprehensive study of pulmonary hilam with its clinical correlation.

Ann Anat 2018 Nov 20;222:61-69. Epub 2018 Nov 20.

Department of Anatomy, Calcutta National Medical College, 32, Gorachand Road, Kolkata, 700014, West Bengal, India. Electronic address:

Introduction: Awareness of pulmonary hilar variations is essential for lobectomy of lung.

Materials And Methods: We studied 54 left and 49 right hilum of formalin fixed adult cadaveric lungs. Morphologic and mophometric details were recorded and variations were noted. Read More

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http://dx.doi.org/10.1016/j.aanat.2018.10.012DOI Listing
November 2018

High-Resolution Chest Computed Tomography Imaging of the Lungs: Impact of 1024 Matrix Reconstruction and Photon-Counting Detector Computed Tomography.

Invest Radiol 2018 Nov 19. Epub 2018 Nov 19.

Siemens Healthineers, Malvern, PA.

Objectives: The aim of this study was to evaluate if a high-resolution photon-counting detector computed tomography (PCD-CT) system with a 1024×1024 matrix reconstruction can improve the visualization of fine structures in the lungs compared with conventional high-resolution CT (HRCT).

Materials And Methods: Twenty-two adult patients referred for clinical chest HRCT (mean CTDI vol, 13.58 mGy) underwent additional dose-matched PCD-CT (mean volume CT dose index, 13. Read More

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http://dx.doi.org/10.1097/RLI.0000000000000524DOI Listing
November 2018
11 Reads

Delivery of pDNA Polyplexes to Bronchial and Alveolar Epithelial Cells Using a Mesh Nebulizer.

Pharm Res 2018 Nov 15;36(1):14. Epub 2018 Nov 15.

Respiratory Technology, Woolcock Institute of Medical Research and Discipline of Pharmacology, Sydney Medical School, Sydney University, 431 Glebe Point Road, Glebe, Camperdown, NSW, 2037, Australia.

Purpose: In this study, a cell penetrating peptide was used as an uptake enhancer for pDNA delivery to the lungs.

Methods: Polyplexes were prepared between pDNA and CPP. Intracellular delivery of pDNA was assessed in both alveolar (A549) and bronchial (Calu-3) epithelial cells. Read More

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http://link.springer.com/10.1007/s11095-018-2542-y
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http://dx.doi.org/10.1007/s11095-018-2542-yDOI Listing
November 2018
6 Reads

Expiratory reactance abnormalities in patients with expiratory dynamic airway collapse: a new application of impulse oscillometry.

ERJ Open Res 2018 Oct 12;4(4). Epub 2018 Nov 12.

Dept of Thoracic Medicine, Royal Brisbane and Women's Hospital, Herston, Australia.

Expiratory dynamic airways collapse (EDAC) is a condition that affects the central airways; it is not well characterised physiologically, with relatively few studies. We sought to characterise impulse oscillometry (IOS) features of EDAC in patients with normal spirometry. Expiratory data were hypothesised to be the most revealing. Read More

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http://openres.ersjournals.com/lookup/doi/10.1183/23120541.0
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http://dx.doi.org/10.1183/23120541.00080-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230814PMC
October 2018
3 Reads

Bronchiectasis.

Nat Rev Dis Primers 2018 Nov 15;4(1):45. Epub 2018 Nov 15.

Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL, USA.

Bronchiectasis refers to abnormal dilatation of the bronchi. Airway dilatation can lead to failure of mucus clearance and increased risk of infection. Pathophysiological mechanisms of bronchiectasis include persistent bacterial infections, dysregulated immune responses, impaired mucociliary clearance and airway obstruction. Read More

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http://www.nature.com/articles/s41572-018-0042-3
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http://dx.doi.org/10.1038/s41572-018-0042-3DOI Listing
November 2018
13 Reads

Enzyme replacement therapy: efficacy and limitations.

Ital J Pediatr 2018 Nov 16;44(Suppl 2):120. Epub 2018 Nov 16.

UOS Malattie Metaboliche Rare, Clinica Pediatrica dell'Università Milano Bicocca, Fondazione MBBM, ATS Monza e Brianza, Via Pergolesi 33, 20900, Monza, Italy.

Enzyme replacement therapy (ERT) is available for mucopolysaccharidosis (MPS) I, MPS II, MPS VI, and MPS IVA. The efficacy of ERT has been evaluated in clinical trials and in many post-marketing studies with a long-term follow-up for MPS I, MPS II, and MPS VI. While ERT is effective in reducing urinary glycosaminoglycans (GAGs) and liver and spleen volume, cartilaginous organs such as the trachea and bronchi, bones and eyes are poorly impacted by ERT probably due to limited penetration in the specific tissue. Read More

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https://ijponline.biomedcentral.com/articles/10.1186/s13052-
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http://dx.doi.org/10.1186/s13052-018-0562-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6238252PMC
November 2018
5 Reads

[A case report of an adult with bronchial mould infection complicated by purulent pleurisy].

Authors:
Fbr Mbaye

Rev Mal Respir 2018 Nov 11. Epub 2018 Nov 11.

Université Cheikh Anta Diop, faculté de médecine service de pneumologie de Fann, Dakar, Sénégal. Electronic address:

Introduction: Bronchial mould infection or plastic bronchitis is a rare condition, encountered at any age, but with a predilection for childhood. The clinical diagnosis is made easy by the demonstration of solid, branched expectorations. However, the aetiology is not easy to determine and investigation does not often lead to a pathological diagnosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07618425183032
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http://dx.doi.org/10.1016/j.rmr.2018.02.013DOI Listing
November 2018
5 Reads

Overexpression of Forkhead box C1 attenuates oxidative stress, inflammation and apoptosis in chronic obstructive pulmonary disease.

Life Sci 2019 Jan 11;216:75-84. Epub 2018 Nov 11.

Department of Respiratory and Critical Care Medicine, Central Hospital Affiliated to Shenyang Medical College, Shenyang 110024, People's Republic of China.

Aim: Chronic obstructive pulmonary disease (COPD) is a disease caused by cigarette smoke, which has been emerging as a serious health problem worldwide. The aim of this study is to explore the mRNA expression profile of lung tissues from the COPD rats and to characterize the role of Forkhead box C1 (Foxc1) in COPD.

Main Methods: Wistar rats were exposed to cigarette smoke during 16 weeks for COPD model establishment. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00243205183072
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http://dx.doi.org/10.1016/j.lfs.2018.11.023DOI Listing
January 2019
6 Reads

Melanoma in the Bronchus.

N Engl J Med 2018 Nov;379(20):e36

Fox Chase Cancer Center, Philadelphia, PA

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http://dx.doi.org/10.1056/NEJMicm1805380DOI Listing
November 2018

Mast cell chymase impairs bronchial epithelium integrity by degrading cell junction molecules of epithelial cells.

Allergy 2018 Nov 14. Epub 2018 Nov 14.

The Faculty of Medicine, The University of Southampton, Southampton, UK.

Background: An increased degree of mast cell (MC) degranulation and damage to the epithelial lining are prominent features of bronchial asthma. In asthmatic airways, it seems likely that epithelial cells will be exposed to increased concentrations of proteases from MC, though their actions on the epithelium are still not very clear.

Methods: Bronchial rings from human lung tissue or 16HBE cell monolayer were incubated with MC chymase in different doses or various inhibitors. Read More

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http://dx.doi.org/10.1111/all.13666DOI Listing
November 2018
1 Read
6.030 Impact Factor

Microarray Profiling of TGF-β1-Induced Long Non-Coding RNA Expression Patterns in Human Lung Bronchial Epithelial BEAS-2B Cells.

Cell Physiol Biochem 2018 13;50(6):2071-2085. Epub 2018 Nov 13.

School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou,

Background/aims: TGF-β1 mediated radiation-induced bystander effects (RIBE) have been linked with malignant transformation and tumorigenesis. However, the underlying mechanisms are not fully understood.

Methods: To reveal new molecules of regulatory functions in this process, lncRNA microarray was performed to profile both lncRNA and mRNA expression patterns in human lung bronchial epithelial BEAS-2B cells treated with TGF-β1 at a concentration measured in the medium conditioned by directly irradiated BEAS-2B cells. Read More

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https://www.karger.com/Article/FullText/495052
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http://dx.doi.org/10.1159/000495052DOI Listing
December 2018
9 Reads
2.880 Impact Factor

Outcome differences between recanalized malignant central airway obstruction from endoluminal disease versus extrinsic compression.

Lasers Med Sci 2018 Nov 12. Epub 2018 Nov 12.

Department of Respiratory and Critical Care Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.

We compared the outcome of Nd:YAG laser therapy with stent placement for malignant central airway obstruction (CAO) at our center over a 10-year period. This is a retrospective review of patients undergoing Nd:YAG laser therapy or self-expanding metal stent (SEMS) placement for malignant CAO between November 2007 and October 2017. Seventy-two patients were recanalized for malignant CAO. Read More

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http://link.springer.com/10.1007/s10103-018-2684-5
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http://dx.doi.org/10.1007/s10103-018-2684-5DOI Listing
November 2018
6 Reads

Surgical treatment of bronchial rupture in blunt chest trauma: a review of literature.

J Thorac Dis 2018 Sep;10(9):5576-5583

Department of Surgery, Zuyderland Medical Center, Heerlen, The Netherlands.

Bronchial rupture by blunt chest trauma is rare. We present a case of bronchial injury after blunt chest trauma that was repaired surgically by primary reconstruction. We performed a review of literature to verify if primary reconstruction is suitable for the treatment of adult patients with blunt bronchial injury. Read More

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http://jtd.amegroups.com/article/view/23258/18359
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http://dx.doi.org/10.21037/jtd.2018.08.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196165PMC
September 2018
8 Reads

Application of the "continuous suture dividing and equal suture tightening" method in video-assisted thoracoscopic surgery sleeve lobectomy.

J Thorac Dis 2018 Sep;10(9):5199-5207

Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Background: The primary focus of video-assisted thoracoscopic surgery (VATS) sleeve lobectomy is bronchial anastomosis. Both interrupted suture and continuous suture cannot overcome entanglement of the suture threads. The present study used the "continuous suture dividing and equal suture tightening" method in VATS sleeve lobectomy for bronchial anastomosis and discussed the feasibility of this approach. Read More

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http://jtd.amegroups.com/article/view/23897/18320
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http://dx.doi.org/10.21037/jtd.2018.08.42DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196206PMC
September 2018
7 Reads

Invasive bronchial fibroblasts derived from asthmatic patients activate lung cancer A549 cells .

Oncol Lett 2018 Nov 19;16(5):6582-6588. Epub 2018 Sep 19.

Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Kraków, Poland.

Epidemiological data suggests that there are functional links between bronchial asthma and lung carcinogenesis. Bronchial fibroblasts serve a prominent role in the asthmatic process; however, their involvement in lung cancer progression remains unaddressed. To estimate the effect of the asthmatic microenvironment on the invasiveness of lung cancer cells, the present study compared the behavior of human non-small cell lung cancer A549 cells exposed to the signals from human bronchial fibroblasts (HBFs) derived from non-asthmatic donors (NA HBFs) and from asthmatic patients (AS HBFs). Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9462
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http://dx.doi.org/10.3892/ol.2018.9462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202494PMC
November 2018
5 Reads

Granulomatosis with Polyangiitis (Wegener's Granulomatosis): Evolving Concepts in Treatment.

Semin Respir Crit Care Med 2018 Aug 7;39(4):434-458. Epub 2018 Nov 7.

Division of Pulmonary, Critical Care Medicine, Allergy and Clinical Immunology, Department of Medicine, The David Geffen School of Medicine at UCLA, Los Angeles, California.

Granulomatosis with polyangiitis (GPA), formerly termed , is the most common of the pulmonary vasculitides. GPA typically involves the upper respiratory tract, lower respiratory tract (bronchi and lung), and kidney, with varying degrees of disseminated vasculitis. Cardinal histologic features include a necrotizing vasculitis involving small vessels, extensive "geographic" necrosis, and granulomatous inflammation. Read More

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http://dx.doi.org/10.1055/s-0038-1660874DOI Listing
August 2018
9 Reads

Angiostrongylosis in Cerdocyon thous (crab-eating fox) and Lycalopex gymnocercus (Pampas fox) in Southern Brazil.

Parasitology 2018 Nov 5:1-8. Epub 2018 Nov 5.

Department of Clinical Veterinary Pathology,Faculdade de Veterinária, Universidade Federal do Rio Grande do Sul (UFRGS),Av. Bento Gonçalves 9090,42505, Porto Alegre, RS 91540-000,Brazil.

The objective of this study was to identify species of Angiostrongylus spp. infecting wild carnivores in Southern Brazil, as well as to describe gross and histopathological findings associated with the infection. Necropsy was conducted in 16 wild carnivores parasitized by Angiostrongylus spp. Read More

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http://dx.doi.org/10.1017/S0031182018001865DOI Listing
November 2018
6 Reads

Volatile substance related deaths: a simple and safe autopsy procedure for sampling and preserving aliphatic hydrocarbons.

Clin Ter 2018 Sep-Oct;169(5):e231-e234

Section of Legal Medicine, SAIMLAL Department, "Sapienza" University of Rome, Rome.

Volatile substance abuse in order to "get high" is a widespread problem especially among adolescents and young-adults, with significant rates of morbidity and mortality. Despite the studies conducted on this topic, collection and preservation of volatile substances in forensic context is still a matter of debate: there are several scientific papers describing materials and procedures for volatile substance sampling while performing post mortem examinations and how they influence the development of the forensic case. Most of the proposed techniques involve the use of specific, and sometimes expensive, gas tight materials that are not always available. Read More

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http://dx.doi.org/10.7417/CT.2018.2084DOI Listing
January 2019

Airway Remodeling in Asthma: Evaluation in 5 Consecutive Bronchial Generations by Using High-Resolution Computed Tomography.

Respir Care 2018 Nov;63(11):1399-1406

Department of Radiology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shanxi, China.

Background: Airway remodeling is a characteristic structural change that occurs extensively in the airways of patients with asthma. The change can be evaluated by measuring airway dimensions by using high-resolution computed tomography. This study aimed to explore the variation trends of airway dimensions from the second- to sixth-generation bronchi in subjects with asthma. Read More

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http://rc.rcjournal.com/lookup/doi/10.4187/respcare.06050
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http://dx.doi.org/10.4187/respcare.06050DOI Listing
November 2018
5 Reads

The Association Between Bronchial Wall CT Attenuation and Spirometry in Patients with Bronchial Asthma.

Acad Radiol 2018 Oct 27. Epub 2018 Oct 27.

Department of Radiology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-Ku, Kawasaki, Kanagawa 216-8511, Japan.

Rationale And Objective: The purpose of this study was to evaluate the correlation between generation-based bronchial wall attenuation on thin-section computed tomography (CT) scans and airflow limitation in patients with bronchial asthma.

Materials And Methods: This study included 28 bronchial asthma patients (13 men, 15 women; age range, 23-89 years) who underwent both chest CT and spirometry. On CT, the mean values of peak wall attenuation, wall area percentage, and luminal area were measured in the segmental, subsegmental, and sub-subsegmental bronchi of the right B1 and B10 bronchi. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10766332183046
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http://dx.doi.org/10.1016/j.acra.2018.09.023DOI Listing
October 2018
14 Reads

Optimizing Lung Collapse With a Bronchial Blocker: It's Not What You Use, but How You Use It, Part II.

J Cardiothorac Vasc Anesth 2019 01 28;33(1):255. Epub 2018 Sep 28.

Department of Respirology and Thoracic Surgery, Institut Universitaire de Cardiologie et de Pneumologie de Quebec - Université Laval, Quebec City, Canada.

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http://dx.doi.org/10.1053/j.jvca.2018.09.025DOI Listing
January 2019
1 Read

Comparison of bronchoscopic and nonbronchoscopic bronchoalveolar lavage in healthy cats.

Am J Vet Res 2018 Nov;79(11):1209-1216

OBJECTIVE To compare bronchoalveolar lavage (BAL) accomplished by use of a bronchoscopic (B-BAL) and a nonbronchoscopic (NB-BAL) technique in healthy cats. ANIMALS 12 healthy cats. PROCEDURES Two BALs were performed in a randomized order 2 weeks apart in each cat. Read More

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http://dx.doi.org/10.2460/ajvr.79.11.1209DOI Listing
November 2018