46,555 results match your criteria Bronchi


Gene Expression Profiling Revealed 2 Types of Bronchial Basal Cell Hyperplasia and Squamous Metaplasia With Different Progression Potentials.

Appl Immunohistochem Mol Morphol 2019 Mar 20. Epub 2019 Mar 20.

Tomsk National Research Medical Center.

The premalignant process preceding squamous cell lung cancer is not inevitable; it can stop at any of the bronchial lesions: basal cell hyperplasia (BCH), squamous metaplasia (SM), and dysplasia and then progress or regress. At present, the mechanisms underlying the progression of the bronchial lesions remain undefined. Previously, we hypothesized that bronchial lesions that presented individually or combined with each other in the bronchi of lung cancer patients mirror the different "scenarios" of the premalignant process: individual BCH-the stoppage at the stage of hyperplasia, BCH plus SM-the progression of hyperplasia to metaplasia, and SM plus dysplasia-the progression of metaplasia to dysplasia. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000762DOI Listing

Long-term management and outcomes of tracheobronchial stent by flexible bronchoscopy in infants < 5 kg: a 13-year single-center experience.

J Chin Med Assoc 2019 Mar 11. Epub 2019 Mar 11.

Department of Pediatrics, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Background: Tracheobronchial (TB) lumen narrowing may require prolonged positive-pressure ventilation, endotracheal tube intubation or even surgical interventions. Therapeutic flexible bronchoscopy (TFB) of balloon-expandable metallic stent (BEMS) placement and subsequent forceps, laser and balloon dilatation management might be less invasive and helpful. This study aimed to analyse the placement, follow-up management with TFB and long-term outcomes in small infants with BEMS. Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000048DOI Listing
March 2019
1 Read

Involvement of epigenetic modification in epithelial immune responses during respiratory syncytial virus infection.

Microb Pathog 2019 Mar 16;130:186-189. Epub 2019 Mar 16.

From Department of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China.

The epithelial cells of bronchi (BECs) act as a protective wall against potential pathogens and foreign particles that controls many aspects of respiratory immune response. The BECs act as not only a physical protecting wall of the airways but also as a significant part of both the innate and adaptive immune responses. Many kind of epithelium-associated communicating pathways which are triggered by genetic and environmental causating agents get involved in development of respiratory tract abnormalities. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.03.019DOI Listing

Pharmacological characterization of the interaction between tiotropium bromide and olodaterol on human bronchi and small airways.

Pulm Pharmacol Ther 2019 Mar 12. Epub 2019 Mar 12.

Unit of Pharmacology, Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

Combining a long-acting β-agonist (LABA) with a long-acting muscarinic antagonist (LAMA) is the cornerstone to treat patients with chronic obstructive pulmonary disease (COPD). In this study we have characterized the interaction between the LAMA, tiotropium bromide, and the LABA, olodaterol, on the contractile tone of human medium bronchi and small airways. The response to a combination of tiotropium bromide and olodaterol was assessed at sub-maximal contractile tone induced by carbachol. Read More

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http://dx.doi.org/10.1016/j.pupt.2019.03.004DOI Listing
March 2019
1 Read

Risk factors for lower respiratory tract infection in children with tracheobronchial foreign body aspiration.

Medicine (Baltimore) 2019 Mar;98(10):e14655

Department of Otolaryngology Head and Neck Surgery, West China Hospital, Sichuan University.

The aim of this study was to determine the risk factors for lower respiratory tract infection (LRTI) in children caused by tracheobronchial foreign body aspiration (TFBA).A total of 351 patients were retrospectively reviewed; all patients were diagnosed with TFBA at West China Hospital of Sichuan University from 2015 to 2017. Univariate analyses and multivariate analysis were used. Read More

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http://dx.doi.org/10.1097/MD.0000000000014655DOI Listing

Recent fluorescence-based optical imaging for video-assisted thoracoscopic surgery segmentectomy.

Ann Transl Med 2019 Jan;7(2):32

Department of Thoracic Surgical Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.

Background: The importance of fluorescence-based optical imaging in various fields of surgery is increasing. This is a prospective cohort study aimed to investigate the feasibility and efficacy of indocyanine-green fluorescence (ICGF)-based navigation for near-infrared (NIR) thoracoscopic segmentectomy.

Methods: ICGF-based video-assisted thoracoscopic surgery (VATS) segmentectomy was performed in 149 patients. Read More

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http://atm.amegroups.com/article/view/23489/22599
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http://dx.doi.org/10.21037/atm.2019.01.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381273PMC
January 2019
1 Read

Improving Clinical Outcomes and Quality of Life with Massage Therapy in Youth and Young Adults with Cystic Fibrosis: a Pilot Study.

Int J Ther Massage Bodywork 2019 Mar 4;12(1):4-15. Epub 2019 Mar 4.

Patient Services, Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Background: Cystic Fibrosis (CF) is an autosomal recessive disorder of exocrine glands characterized by abnormal production of thick mucus, primarily in bronchi of the lungs. Individuals experience recurrent respiratory infections, increased work of breathing, cough and musculoskeletal changes with pain. Previous research found that massage therapy (MT) decreased pain, muscle tightness, and anxiety in individuals with CF, but did not use valid/reliable measurements of quality of life (QOL). Read More

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March 2019
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Medial approach for subcarinal lymphadenectomy during thoracoscopic esophagectomy in the prone position.

Langenbecks Arch Surg 2019 Mar 7. Epub 2019 Mar 7.

Division of Gastrointestinal Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.

Purpose: In esophageal squamous cell carcinoma (ESCC), lymph nodes (LNs) around the subcarina and main bronchi are thought to be highly involved. Therefore, complete dissection of these LNs with preservation of the pulmonary branches of the vagus nerves, which control important pulmonary functions, is recommended. The aim of this retrospective study was to investigate the feasibility of reliable method for lymphadenectomy around the subcarina and main bronchi, named the medial approach, during thoracoscopic esophagectomy in the prone position (TEP). Read More

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http://dx.doi.org/10.1007/s00423-019-01772-3DOI Listing

[Effects of 3-methyladenine on airway inflammation, airway hyperresponsiveness and mucus secretion in asthmatic mice].

Zhonghua Jie He He Hu Xi Za Zhi 2019 Mar;42(3):185-192

Department of Respiratory Medicine, Third People's Hospital, Chengdu 610000, China.

To investigate the effects of 3-methyladenine on airway inflammation, airway hyperresponsiveness and mucus secretion in asthmatic mice, and to explore its mechanism. C57BL/6J female mice were randomly divided into normal control group (PBS), OVA group(OVA), OVA with 3-methyladenine group (OVA+3-MA), and OVA with 4-phenylbutyrate group (OVA+4-PBA). OVA group, OVA+3-MA group and OVA+4-PBA groups were all sensitized and challenged with OVA to establish asthmatic models, while PBS group was given PBS as a control. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2019.03.008DOI Listing
March 2019
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Changes in topographical relation between the ductus arteriosus and left subclavian artery in human embryos: a study using serial sagittal sections.

Folia Morphol (Warsz) 2019 Mar 5. Epub 2019 Mar 5.

Department of Anatomy and Human embryology, Institute of Embryology, Faculty of Medicine, Complutense University, Madrid, Spain.

At birth, the ductus arteriosus (DA) merges with the aortic arch in the slightly caudal side of the origin of the left subclavian artery (SCA). Since the SCA (seventh segmental arteries) were fixed on a level of the seventh cervical-first thoracic vertebral bodies, the confluence of DA should migrate caudally. We aimed to describe timing and sequence of the topographical change using serial sagittal sections of 36 human embryos and fetuses (CRL 8-64 mm; 5-10 weeks) those made easy evaluation of the vertebral levels possible in a few section. Read More

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http://dx.doi.org/10.5603/FM.a2019.0028DOI Listing

[PECULIARITIES OF STRUCTURAL CHANGES IN RAT LUNGS IN APPLICATION OF DIFFERENT METHODS OF REHYDRATION AFTER GENERAL DEHYDRATION].

Georgian Med News 2019 Jan(286):106-111

I. Horbachevsky Ternopil State Medical University of Ministry of Healthcare of Ukraine, Ternopil, Ukraine.

Dehydration of the organism leads to the disturbances in homeostasis and structural changes in the lungs. Inadequate rehydration can also lead to the undesirable consequences. Experiments were carried out on rats, which modeled general dehydration and its correction: with metered potable water consumption, with water consumption without restrictions and correction by using a physiological solution. Read More

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January 2019

Primary salivary gland-type tumors of the lung: A systematic review and pooled analysis.

Lung India 2019 Mar-Apr;36(2):118-122

Department of Cancer Surgery, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Introduction: Primary salivary gland-type tumors of the lung (PSGTTL) are rare intrathoracic malignant neoplasms. Their description in literature is largely limited to a few case series and case reports. A systematic review and pooled analysis of the previously reported cases of PSGTTL is presented here. Read More

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http://dx.doi.org/10.4103/lungindia.lungindia_284_18DOI Listing
March 2019
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A retrospective study comparing the ultrathin versus conventional bronchoscope for performing radial endobronchial ultrasound in the evaluation of peripheral pulmonary lesions.

Lung India 2019 Mar-Apr;36(2):102-107

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background: Few studies have reported on the utility of ultrathin bronchoscopes (UTBs) for performing radial probe endobronchial ultrasound (EBUS). Herein, we describe our experience with UTB and conventional bronchoscope (CB) for performing radial EBUS.

Materials And Methods: This was a retrospective study comparing the diagnostic yield of a prototype UTB (external diameter 3 mm, working channel diameter 1. Read More

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http://dx.doi.org/10.4103/lungindia.lungindia_115_18DOI Listing

Vitamin D and disease severity in bronchiectasis.

Respir Med 2019 Mar 24;148:1-5. Epub 2019 Jan 24.

Respiratory Medicine, AOU "Policlinico - Vittorio Emanuele", University of Catania, Catania, Italy.

Background: Bronchiectasis is a complex respiratory disease characterised by permanent dilatation of bronchi. Vitamin D plays a role in infective disease by modulating the inflammation. Patients affected by bronchiectasis are frequently Vitamin D deficient and it correlates with lung function decline. Read More

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http://dx.doi.org/10.1016/j.rmed.2019.01.009DOI Listing
March 2019
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Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches.

Immunity 2019 Mar 26;50(3):707-722.e6. Epub 2019 Feb 26.

Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA 94143, USA; Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

Type 2 lymphocytes promote both physiologic tissue remodeling and allergic pathology, yet their physical tissue niches are poorly described. Here, we used quantitative imaging to define the tissue niches of group 2 innate lymphoid cells (ILC2s), which are critical instigators of type 2 immunity. We identified a dominant adventitial niche around lung bronchi and larger vessels in multiple tissues, where ILC2s localized with subsets of dendritic and regulatory T cells. Read More

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http://dx.doi.org/10.1016/j.immuni.2019.02.002DOI Listing

Magnetic aerosol drug targeting in lung cancer therapy using permanent magnet.

Drug Deliv 2019 Dec;26(1):120-128

a Department of Mechanical and Manufacturing Engineering , University of Calgary , Calgary , Alberta , Canada.

Primary bronchial cancer accounts for almost 20% of all cancer death worldwide. One of the emerging techniques with tremendous power for lung cancer therapy is magnetic aerosol drug targeting (MADT). The use of a permanent magnet for effective drug delivery in a desired location throughout the lung requires extensive optimization, but it has not been addressed yet. Read More

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http://dx.doi.org/10.1080/10717544.2018.1561765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394297PMC
December 2019
1 Read

3D-printed, externally-implanted, bioresorbable airway splints for severe tracheobronchomalacia.

Laryngoscope 2019 Feb 22. Epub 2019 Feb 22.

Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan.

Objectives/hypothesis: To report the clinical safety and efficacy of three-dimensional (3D)-printed, patient-specific, bioresorbable airway splints in a cohort of critically ill children with severe tracheobronchomalacia.

Study Design: Case series.

Methods: From 2012 to 2018, 15 subjects received 29 splints on their trachea, right and/or left mainstem bronchi. Read More

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http://dx.doi.org/10.1002/lary.27863DOI Listing
February 2019
3 Reads

[Bronchial thermoplasty in the management of severe asthma : retrospective analysis of 10 cases treated at academic hospital of Liège].

Rev Med Liege 2019 Feb;74(2):74-81

Service de Pneumologie, CHU de Liège, Belgique.

As treating severe forms of asthma represents a medical and economical challenge, research for new therapies in this area is extensive and expansive. Recently, bronchial thermoplasty (BT) - ie. bronchoscopic procedure delivering a thermic form of energy through radiofrequency to the bronchi, in order to interfere with the components of the smooth muscle layer - arose as a promising technique. Read More

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February 2019

Stereotactic body radiotherapy for centrally located stage I non-small cell lung cancer.

Transl Lung Cancer Res 2019 Feb;8(1):58-69

Department of Radiation Oncology, University of Toronto, Toronto, Canada.

Stereotactic body radiotherapy (SBRT) has become the standard of care for the treatment of early stage non-small cell lung cancer in high risk or medically inoperable patients. It is very well tolerated when given to peripherally located tumors and is associated with high rates of local control. Centrally located tumors represent a bigger challenge as they are closer to a number of critical structures, namely the major bronchi, esophagus, large vessels and brachial plexus, that can be damaged by the high ablative doses of SBRT needed for optimal tumor control. Read More

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http://dx.doi.org/10.21037/tlcr.2018.10.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351397PMC
February 2019
1 Read

Cellular Senescence in the Lung Across the Age Spectrum.

Am J Physiol Lung Cell Mol Physiol 2019 Feb 20. Epub 2019 Feb 20.

Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, United States.

Cellular senescence results in cell cycle arrest with secretion of cytokines, chemokines, growth factors and remodeling proteins (senescence associated secretory phenotype; SASP) that have autocrine and paracrine effects on the tissue microenvironment. SASP can promote remodeling, inflammation, infectious susceptibility, angiogenesis and proliferation, while hindering tissue repair and regeneration. While the role of senescence and contributions of senescent cells are increasingly recognized in the context of aging and a variety of disease states, relatively less is known regarding the portfolio and influences of senescent cells in normal lung growth and aging per se, or in the induction or progression of lung diseases across the age spectrum such as bronchopulmonary dysplasia, asthma, COPD, or pulmonary fibrosis. Read More

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http://dx.doi.org/10.1152/ajplung.00424.2018DOI Listing
February 2019
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Identification of whole blood mRNA and microRNA biomarkers of tissue damage and immune function resulting from amphetamine exposure or heat stroke in adult male rats.

PLoS One 2019 19;14(2):e0210273. Epub 2019 Feb 19.

Division of Neurotoxicology, NCTR/U.S. Food and Drug Administration, Jefferson, Arkansas, United States of America.

This work extends the understanding of how toxic exposures to amphetamine (AMPH) adversely affect the immune system and lead to tissue damage. Importantly, it determines which effects of AMPH are and are not due to pronounced hyperthermia. Whole blood messenger RNA (mRNA) and whole blood and serum microRNA (miRNA) transcripts were identified in adult male Sprague-Dawley rats after exposure to toxic AMPH under normothermic conditions, AMPH when it produces pronounced hyperthermia, or environmentally-induced hyperthermia (EIH). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210273PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380594PMC
February 2019
2 Reads

A case report and review of literature of Dieulafoy's disease of bronchus: A rare life-threatening pathologic vascular condition.

Medicine (Baltimore) 2019 Feb;98(7):e14471

Department of Respiratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine.

Rationale: Dieulafoy's lesions are characterized by the presence of a dysplastic artery in the submucosa, most frequently associated with gastrointestinal hemorrhage. They are rarely identified in the bronchial submucosa and can cause massive or fatal hemoptysis PATIENT CONCERNS:: The patient was a 62-year-old male farmer with intermittent hemoptysis of approximately 2 years duration and a definite diagnosis could not be established.

Diagnosis: A thorax-computed tomography at our hospital revealed that the bronchus of left lower lobe was narrowed with associated local atelectasis, and lung cancer was suspected. Read More

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http://dx.doi.org/10.1097/MD.0000000000014471DOI Listing
February 2019
2 Reads

Wine cup stoma anastomosis after extended sleeve lobectomy for central-type squamous cell lung cancer.

J Cardiothorac Surg 2019 Feb 12;14(1):36. Epub 2019 Feb 12.

Department of Chest Surgery, Fukushima Medical University School of Medicine, Fukushima, 960-1295, Japan.

Background: Extended sleeve lobectomy is rarely applied to pulmonary surgery for primary lung cancer to avoid a pneumonectomy. As there is a size discrepancy between main bronchus and peripheral bronchus, ingenuity to improve anastomosis is required in the bronchoplasty. We report herein a case in which successful reconstruction of extended sleeve lobectomy with bronchial wall flap. Read More

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http://dx.doi.org/10.1186/s13019-019-0857-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373146PMC
February 2019
1 Read

Secondary resection tracheal was facilitated in robot-assisted left pneumonectomy.

J Thorac Dis 2018 Dec;10(12):7005-7008

Department of Thoracic Surgery, Tangdu Hospital, Air Force Medical University, Xi'an 710038, China.

The purpose of the essay is to introduce a new procedure in term of robot-assisted left pneumonectomy. The "secondary resection tracheal" technique is that, the left bronchi, which was 3-4 cm apart from trachea carina was disserted firstly, as the distal bronchi stump was lifted, with more space and vision being explored, the artery was pinned down easily, chipped and cut accurately. As far as the program goes down, it is more privileged but one point where it was capable of avoiding or decreasing the risk of ripping the left artery. Read More

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http://jtd.amegroups.com/article/view/26046/19484
Publisher Site
http://dx.doi.org/10.21037/jtd.2018.11.136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344697PMC
December 2018
3 Reads

Feasibility of low-dose CT with spectral shaping and third-generation iterative reconstruction in evaluating interstitial lung diseases associated with connective tissue disease: an intra-individual comparison study.

Eur Radiol 2019 Feb 8. Epub 2019 Feb 8.

Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, No.1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China.

Objectives: To investigate the feasibility of low-dose CT (LDCT) with tin filtration and third-generation iterative reconstruction (IR) in evaluating interstitial lung diseases associated with connective tissue disease (CTD-ILD).

Methods: Fifty-three consecutive adult patients with CTD-ILD underwent regular-dose chest CT (RDCT) at 110 kVp followed by LDCT with tin-filtered 100 kVp. RDCT was reconstructed with filtered back projection (FBP) and advanced modeled iterative reconstruction (ADMIRE); LDCT was reconstructed with ADMIRE. Read More

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http://dx.doi.org/10.1007/s00330-018-5969-yDOI Listing
February 2019
1 Read

Detection of Bovine Respiratory Syncytial Virus, and by Immunohistochemical Method in Naturally-infected Cattle.

J Vet Res 2018 Dec 31;62(4):439-445. Epub 2018 Dec 31.

Department of Pathology, Faculty of Veterinary Medicine, Van Yuzuncu Yil University, 65090, Van, Turkey.

Introduction: The aim of this study was to determine the predisposing effect of bovine respiratory syncytial virus (BRSV) on spp. infection in naturally-induced pneumonia in cattle by immunohistochemical labelling.

Material And Methods: Lungs of cattle slaughtered in the slaughterhouse were examined macroscopically, and 100 pneumonic samples were taken. Read More

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http://dx.doi.org/10.2478/jvetres-2018-0070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364159PMC
December 2018

An anatomical study of the right bronchial tree using multi-detector computed tomography.

Surg Radiol Anat 2019 Mar 6;41(3):335-338. Epub 2019 Feb 6.

Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong University, 324#, Jingwu Road, Jinan, 250021, Shandong, China.

Purpose: The aims were to study the pattern of right bronchial tree with multi-detector CT.

Methods: 238 patients were enrolled. The three-dimensional bronchial tree images were acquired using the post-processing technique of CT. Read More

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http://dx.doi.org/10.1007/s00276-019-02199-7DOI Listing
March 2019
2 Reads

Post-infective bronchiectasis by measles prior infection - A case report.

Respir Med Case Rep 2019 18;26:203-205. Epub 2019 Jan 18.

Pneumology B Unit, University Hospital Center of Coimbra, Coimbra, Portugal.

Bronchiectasis (BE) refers to an abnormal and irreversible dilatation of the bronchi. Post-infectious etiology still remains an important and frequent cause. Associated the anti-vaccine movement, measles resurfaces and with all the outcomes that comes from the disease. Read More

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http://dx.doi.org/10.1016/j.rmcr.2019.01.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350261PMC
January 2019
9 Reads

Radial probe endobronchial ultrasound assisted conventional transbronchial needle aspiration in the diagnosis of solitary peribronchial pulmonary lesion located in the segmental bronchi.

J Cancer 2019 1;10(3):634-642. Epub 2019 Jan 1.

3rd Surgery Department, "AHEPA" University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.

The diagnosis of peribronchial pulmonary lesions located in the tertiary bronchi, also known as segmental bronchi, as well as, the 4th order and 5th order segmental bronchi is very difficult. Histopathological specimens cannot be easily obtained by endobronchial biopsies (EBBX) due to the patent but small segmental bronchial lumen. The aim of the present study was to evaluate the diagnostic accuracy and safety of the novel technique with radial probe endobronchial ultrasound (R-EBUS) assisted conventional transbronchial needle aspiration (C-TBNA) in the diagnosis of solitary peribronchial pulmonary lesions located in segmental bronchi from 3th to 5th order. Read More

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http://dx.doi.org/10.7150/jca.28755DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360410PMC
January 2019
4 Reads

Radiation-induced thoracic necrosis with a pulmonary cutaneous fistula repaired using a free omental flap: a case report.

BMC Surg 2019 Feb 2;19(1):14. Epub 2019 Feb 2.

Department of Plastic Surgery, National Defense Medical College, 3-2 Namiki Tokorozawa, Saitama, 359-0042, Japan.

Background: Chest wall necrosis can manifest as a late effect of radiation therapy for breast cancer. Only two cases of fistulas communicating with the respiratory tract as a result of radiation-induced necrosis of the lungs or bronchi have been reported. To the best of our knowledge, we report the first case of a pulmonary cutaneous fistula arising as a late effect of radiation therapy for breast cancer, which was successfully repaired using a free omental graft. Read More

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https://bmcsurg.biomedcentral.com/articles/10.1186/s12893-01
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http://dx.doi.org/10.1186/s12893-019-0479-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360029PMC
February 2019
6 Reads

[Experimental study on the pathological changes in lung of abdominal compartment syndrome model rabbits].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2019 Jan;31(1):112-114

Department of Oncology, the Affiliated Hospital of Datong University, Datong 037005, Shanxi, China. Corresponding author: Wang Hongye, Email:

Objective: To investigate the secondary pathological changes in lung of abdominal compartment syndrome (ACS).

Methods: Twenty-five healthy adult clean New Zealand rabbits were randomly divided into control group (n = 5) and experimental group (n = 20) according to the random number table method. The experimental group was subdivided into two subgroups according to the observation time: 24 hours and 48 hours, with 10 rabbits in each subgroup. Read More

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http://dx.doi.org/10.3760/cma.j.issn.2095-4352.2019.01.022DOI Listing
January 2019
1 Read

The effect of single pretreatment with salbutamol on recovery of bronchoalveolar lavage fluid in horses with suspected or confirmed severe equine asthma.

J Vet Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Internal Diseases with Clinic for Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland.

Background: Bronchoalveolar lavage (BAL) is a method for the recovery of respiratory secretion from the lower airways.

Objectives: To investigate if the administration of a single dose of a bronchodilatator in horses with a suspected or confirmed severe equine asthma could improve recovery of bronchoalveolar lavage fluid (BALF).

Animals: Twenty-eight horses with severe equine asthma. Read More

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http://dx.doi.org/10.1111/jvim.15359DOI Listing
February 2019
1 Read

Inadequate steroid injection after esophageal ESD might cause mural necrosis.

Endosc Int Open 2019 Feb 17;7(2):E115-E121. Epub 2019 Jan 17.

Division of Research and Development for Minimally Invasive Treatment, Cancer Center, Keio University School of Medicine, Tokyo, Japan.

 Locoregional triamcinolone acetonide (TAC) injection is increasingly used for prevention of stricture after extensive endoscopic submucosal dissection (ESD) for superficial esophageal neoplasia. However, the safety of intramural TAC injection has not been elucidated. The aim of this study was to assess the clinical courses and histopathological changes after TAC injection into the muscle layer in a porcine model. Read More

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http://dx.doi.org/10.1055/a-0781-2333DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336468PMC
February 2019
2 Reads

Bronchial angiolipoma successfully treated by sleeve resection of the right bronchus intermedius: a case report.

BMC Surg 2019 Jan 31;19(1):13. Epub 2019 Jan 31.

Department of Thoracic Surgery, Iwate Prefectural Central Hospital, Ueda 1-4-1, Morioka, 020-0066, Japan.

Background: Angiolipoma is a rare, benign tumor that primarily develops in the limbs and trunk. The occurrence of angiolipoma in the lungs is extremely rare; to date, only two cases of primary bronchial angiolipoma have been reported. Here, we report a case of angiolipoma of the right bronchus intermedius that was successfully treated with sleeve resection and reconstructive surgery. Read More

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http://dx.doi.org/10.1186/s12893-019-0481-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357366PMC
January 2019

Percutaneous Bronchial Embolization to Treat Intractable Bronchobiliary Fistula.

Cardiovasc Intervent Radiol 2019 Jan 25. Epub 2019 Jan 25.

Department of Radiology, Center for Liver Cancer, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10408, Republic of Korea.

Sixty-four-year-old female who underwent hemi-hepatectomy for intrahepatic cholangiocarcinoma a year ago presented with biliary sputum, cough and fever. Cross-sectional imaging showed a recurred tumor involving right diaphragmatic area and an abscess formation in liver dome with adjacent right lower lobe of lung. Percutaneous transhepatic biliary drainage and percutaneous drainage of lung abscess were performed. Read More

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http://link.springer.com/10.1007/s00270-019-02166-0
Publisher Site
http://dx.doi.org/10.1007/s00270-019-02166-0DOI Listing
January 2019
6 Reads

Can we prevent recurrences in the endoscopic treatment of endobronchial hamartomas?

Tuberk Toraks 2018 Dec;66(4):312-316

Clinic of Interventional Pulmonology, Ankara Ataturk Chest Diseases and Chest Surgery Training and Research Hospital, Ankara, Turkey.

Introduction: Recently, treatment of endobronchial hamartomas with interventional bronchoscopic methods has become possible. Although there are several reports of therapeutic benefits, the protocol of administration varies between centers and high recurrence rates continue to be a problem. In this study, we aimed to show that cryotherapy applied to the root of the bronchial wall after removal of the intraluminal portion of endobronchial hamartoma with interventional bronchoscopic methods can prevent recurrences. Read More

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http://dx.doi.org/10.5578/tt.67434DOI Listing
December 2018

Micro-scale to Meso-scale Analysis of Parenchymal Tethering: The Effect of Heterogeneous Alveolar Pressures on the Pulmonary Mechanics of Compliant Airways.

J Appl Physiol (1985) 2019 Jan 24. Epub 2019 Jan 24.

Biomedical Engineering, Tulane University, United States.

In the healthy lung, bronchi are tethered open by the surrounding parenchyma; for a uniform distribution of these peri-bronchial structures, the solution is well known. An open question remains regarding the effect of a distributed set of collapsed alveoli, as can occur in disease. Here we address this question by developing and analyzing micro-scale finite-element models of systems of heterogeneously inflated alveoli to determine the range and extent of parenchymal tethering effects on a neighboring collapsible airway. Read More

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http://dx.doi.org/10.1152/japplphysiol.00178.2018DOI Listing
January 2019
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A Multiscale Ray-Shooting Model for Termination Detection of Tree-Like Structures in Biomedical Images.

IEEE Trans Med Imaging 2019 Jan 15. Epub 2019 Jan 15.

Digital reconstruction (tracing) of tree-like structures, such as neurons, retinal blood vessels and bronchi, from volumetric images and 2D images is very important to biomedical research. Many existing reconstruction algorithms rely on a set of good seed points. 2D or 3D terminations are good candidates for such seed points. Read More

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http://dx.doi.org/10.1109/TMI.2019.2893117DOI Listing
January 2019
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Correlation of the modified Medical Research Council dyspnea scale with airway structure assessed by three-dimensional CT in patients with chronic obstructive pulmonary disease.

Respir Med 2019 Jan 12;146:76-80. Epub 2018 Dec 12.

Second Division, Department of Internal Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, 431-3192, Japan.

Background: Dyspnea is a common symptom in chronic obstructive pulmonary disease (COPD). The modified Medical Research Council (mMRC) dyspnea scale is a widely used questionnaire to assess dyspnea. However, the relationship of the mMRC dyspnea scale with morphological airway structures in COPD remains unclear. Read More

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http://dx.doi.org/10.1016/j.rmed.2018.11.020DOI Listing
January 2019
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Generation of lung organoids from human pluripotent stem cells in vitro.

Nat Protoc 2019 Feb;14(2):518-540

Program in Cell and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI, USA.

The lung epithelium is derived from the endodermal germ layer, which undergoes a complex series of endoderm-mesoderm-mediated signaling events to generate the final arborized network of conducting airways (bronchi, bronchioles) and gas-exchanging units (alveoli). These stages include endoderm induction, anterior-posterior and dorsal-ventral patterning, lung specification, lung budding, branching morphogenesis, and, finally, maturation. Here we describe a protocol that recapitulates several of these milestones in order to differentiate human pluripotent stem cells (hPSCs) into ventral-anterior foregut spheroids and further into two distinct types of organoids: human lung organoids and bud tip progenitor organoids. Read More

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http://dx.doi.org/10.1038/s41596-018-0104-8DOI Listing
February 2019
2 Reads

Sex differences of brain and their implications for personalized therapy.

Pharmacol Res 2019 Mar 16;141:429-442. Epub 2019 Jan 16.

Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123 Brescia, Italy; Interdipartimental University Center of Research "Adaption and Regeneration of Tissues and Organs-(ARTO)", University of Brescia, 25123 Brescia, Italy.

Nowadays, it is known that the sex differences regard many organs, e.g., liver, vessels, pancreas, lungs, bronchi and also the brain. Read More

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http://dx.doi.org/10.1016/j.phrs.2019.01.030DOI Listing
March 2019
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Combined airway and esophageal stents implantation for malignant tracheobronchial and esophageal disease: A STROBE-compliant article.

Medicine (Baltimore) 2019 Jan;98(3):e14169

Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University.

We aimed to evaluate the safety and efficacy of combined airway and esophageal stents under fluoroscopy guidance and local anesthesia for patients with malignant tracheobronchial and esophageal disease. This retrospective analysis included 35 consecutive patients underwent combined stenting from March 2012 to August 2016. All patients underwent chest computed tomography scans before stenting and during follow-up. Read More

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http://dx.doi.org/10.1097/MD.0000000000014169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6370007PMC
January 2019
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Mouse Models Reveal Role of T-Cytotoxic and T-Reg Cells in Immune Response to Influenza: Implications for Vaccine Design.

Viruses 2019 Jan 11;11(1). Epub 2019 Jan 11.

Burnett School of Biomedical Sciences, University of Central Florida Medical School, Orlando, FL 32816, USA.

Immunopathologic examination of the lungs of mouse models of experimental influenza virus infection provides new insights into the immune response in this disease. First, there is rapidly developing perivascular and peribronchial infiltration of the lung with T-cells. This is followed by invasion of T-cells into the bronchiolar epithelium, and separation of epithelial cells from each other and from the basement membrane leading to defoliation of the bronchial epithelium. Read More

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http://www.mdpi.com/1999-4915/11/1/52
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http://dx.doi.org/10.3390/v11010052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6356589PMC
January 2019
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Residual airway foreign bodies in children who underwent rigid bronchoscopy.

Int J Pediatr Otorhinolaryngol 2019 Mar 7;118:170-176. Epub 2019 Jan 7.

Department of Cardiothoracic Surgery, Children's Hospital, Zhejiang University School of Medicine, China. Electronic address:

Objective: To analyze the causes of residual airway foreign bodies in children who underwent rigid bronchoscopy in order to improve the success rate of primary surgery.

Methods: Clinical data from 1130 children with airway foreign bodies, including 736 males and 394 females aged 0.42-14 years, who underwent rigid bronchoscopy in our hospital from January 2015 to May 2018 were retrospectively collected and analyzed by cluster sampling. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876193000
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http://dx.doi.org/10.1016/j.ijporl.2019.01.007DOI Listing
March 2019
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miR-145-5p is associated with smoke-related chronic obstructive pulmonary disease via targeting KLF5.

Chem Biol Interact 2019 Feb 9;300:82-90. Epub 2019 Jan 9.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, China.

Increasing evidence illustrate that dysregulation of microRNAs (miRNAs) is involved in the pathogenesis of chronic obstructive pulmonary disease (COPD), which is mainly resulted from cigarette smoke (CS) exposure. However, the role of miR-145-5p in CS-mediated COPD remains largely unknown. Thus, the aim of this study was to investigate the expression level of miR-145-5p in 31 human lung tissues samples, and to explore its regulatory role in the apoptosis and inflammation of human bronchial epithelial cells (HBECs) following CS extract (CSE) exposure. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.01.011DOI Listing
February 2019
2 Reads

Palatal rhinosporidiosis: an unusual case report and review of the literature.

J Korean Assoc Oral Maxillofac Surg 2018 Dec 28;44(6):293-297. Epub 2018 Dec 28.

Department of Oral and Maxillofacial Pathology, Institute of Dental Sciences, Rohilkhand University, Bareilly, India.

Rhinosporidiosis is a chronic, granulomatous, mucocutaneous infection caused by Rhinosporidium seeberi . The infection is non-contagious and sporadic in humans. The site most commonly affected is the mucous membrane of the nose and nasopharynx, followed by the oropharynx, trachea, bronchi, ear, eye, and genitourinary tract. Read More

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http://dx.doi.org/10.5125/jkaoms.2018.44.6.293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327010PMC
December 2018
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[Clinical analysis of 5 cases of endobronchial hamartoma].

Zhonghua Jie He He Hu Xi Za Zhi 2019 Jan;42(1):15-19

Department of Respiratory and Critical Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China.

To analyze the clinical manifestations of patients with endobronchial hamartoma(EH),and therefore to improve understanding of the disease. Data were retrospectively reviewed to describe the clinical characteristics, diagnosis procedures and prognosis of EH, including 5 patients in Beijing Anzhen Hospital, Capital Medical University from Jun 2007 to Feb 2018 and another 159 patients from Chinese and English literatures published after Jan 2000. The five patients, 4 males and 1 female, aged from 46 to 69 years[mean (56±7) years], were diagnosed with EH in our hospital. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1001-0939.2019.01.006DOI Listing
January 2019
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Case of Solitary Peritoneal Metastasis From Atypical Bronchopulmonary Carcinoid on 18F-FDG PET/CT.

Clin Nucl Med 2019 Mar;44(3):e154-e157

Department of Histopathology, HCG Cancer Centre, Bangalore, India.

Atypical lung carcinoids frequently metastasize to mediastinal nodes, liver, bone, lungs, and brain and rarely to ovaries, pancreas, subcutaneous, and skin. Solitary peritoneal metastasis is extremely rare and unreported previously. We present a case of a 36-year-old woman with cough, hemoptysis, dyspnea with detection of lung mass, and incidental detection of pelvic mass. Read More

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http://dx.doi.org/10.1097/RLU.0000000000002441DOI Listing
March 2019
4 Reads