49,555 results match your criteria Bronchi

Bronchial epithelia from adults and children: SARS-CoV-2 spread via syncytia formation and type III interferon infectivity restriction.

Proc Natl Acad Sci U S A 2022 Jul 24;119(28):e2202370119. Epub 2022 Jun 24.

UMR 5234, Microbiologie Fondamentale et Pathogénicité, CNRS, Université de Bordeaux, 33076 Bordeaux, France.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections initiate in the bronchi of the upper respiratory tract and are able to disseminate to the lower respiratory tract, where infections can cause an acute respiratory distress syndrome with a high degree of mortality in elderly patients. We used reconstituted primary bronchial epithelia from adult and child donors to follow the SARS-CoV-2 infection dynamics. We show that, in epithelia from adult donors, infections initiate in multiciliated cells and spread within 24 to 48 h throughout the whole epithelia. Read More

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Predictive risk score of respiratory complications in children with mediastinal tumors: A case-control study.

Cancer Med 2022 Jun 23. Epub 2022 Jun 23.

Department of Hematology/Oncology, Saitama Children's Medical Center, Saitama, Japan.

Background: The aim of this study was to examine risk factors of respiratory complications at the diagnosis and establish an algorithm of clinical management in children and adolescents with mediastinal tumors.

Methods: We retrospectively collected clinical information of all children and adolescents who presented with mediastinal tumors at Saitama Children's Medical Center from 1999 to 2019, including age, sex, pathological diagnosis, eight major clinical symptoms (cough, dyspnea, hypoxia, orthopnea, chest pain, wheeze, superior vena cava syndrome, and stridor), chest computed tomography (CT) findings (tumor location, mediastinal mass ratio, pleural fluid, pericardial effusion, and compression of trachea and bronchi), types of diagnostic procedure and anesthesia, respiratory complications (severe hypoxia, difficult ventilation, respiratory failure, and cardiopulmonary arrest), and clinical outcome. Subsequently, we calculated the risk score for predicting respiratory complications by combining clinical and radiological findings. Read More

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Treatment of a pneumatocele in a COVID-19 patient with endobronchial valves.

BMJ Case Rep 2022 Jun 21;15(6). Epub 2022 Jun 21.

Department of Cardio-thoracic Surgery, Oslo University Hospital, Oslo, Norway.

A man in his 40s was admitted to his local hospital 6 days after the first vague symptoms of COVID-19. His general condition deteriorated, and he was treated in the intensive care unit but did not require mechanical ventilation. During his recovery, he experienced a cough spell, after which his dyspnoea recurred and rapidly increased. Read More

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Awake intubation for thoracic aortic aneurysm causing esophageal stenosis with food residues and compression of the pulmonary artery and left bronchi: a case report.

JA Clin Rep 2022 Jun 21;8(1):46. Epub 2022 Jun 21.

Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, Midorigaoka-higashi 2-1-1-1, Asahikawa, Hokkaido, 078-8510, Japan.

Background: Anesthetic management of thoracic aortic aneurysms (TAAs) is sometimes difficult due to fatal complications, including hypovolemic shock secondary to aneurysm rupture. We report the successful management of an impending rupture of a TAA with associated esophageal stenosis and compression of the pulmonary artery and left bronchi.

Case Presentation: An 83-year-old woman, diagnosed with an impending rupture of the ascending TAA, was scheduled to undergo emergency total aortic arch replacement. Read More

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Single-port combined subsegment resection (RS3b + S1bi) with a rare branching segment pattern of the bronchi and vessels: case report and literature review.

Ann Transl Med 2022 May;10(10):613

Department of Thoracic Surgery, Ruijin Hospital North Campus, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Background: Video-assisted thoracoscopic surgery segmentectomy is increasingly being used to resect peripheral small lung cancer. However, to manage some lesions which locate between segment deep inside the parenchyma is still challenging. Generally, wedge resection and segmentectomy are optional for peripheral small lung cancer. Read More

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An assessment of branching asymmetry of the tracheobronchial tree.

Antonio F Miguel

Sci Rep 2022 Jun 16;12(1):10145. Epub 2022 Jun 16.

Institute of Earth Sciences and Department of Physics, School of Science and Technology, University of Evora, Rua Romao Ramalho 59, 7000-671, Évora, Portugal.

The tracheobronchial tree is commonly seen to have a systematic branching symmetry, despite being known to have an asymmetrical design. Branching asymmetry allows for uniform airflow and provides robustness against the morphogenesis-related size variability. Here, a constructal approach is used to tracheobronchial tree analysis, and a general model based on entropy generation during breathing process is provided, which holds with asymmetric characteristics of the tree, and the change for inhaling and exhaling air. Read More

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Inhalation Potential of Rifampicin-Loaded Novel Metal-Organic Frameworks for Improved Lung Delivery: Physicochemical Characterization, Aerosolization and Antimycobacterial Studies.

J Aerosol Med Pulm Drug Deliv 2022 Jun 16. Epub 2022 Jun 16.

Department of Pharmaceutics, ISF College of Pharmacy, Moga, Affiliated to I.K. Gujral Punjab Technical University, Jalandhar, Punjab, India.

The aim of the current study was to examine the potential of a rifampicin-loaded metal-organic framework ([email protected]) for management of tuberculosis. [email protected] was developed using a simple, economic, and environmentally friendly ultrasonication method. Furthermore, the developed metal-organic framework (MOF) formulations were subjected to physicochemical characterization analyses such as Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), powder X-ray diffractometry, thermogravimetric analysis, field emission-scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), and UV spectroscopy. Read More

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Tracheobronchitis in patients with diffuse wall thickening: Three case reports.

Clin Case Rep 2022 Jun 9;10(6):e5963. Epub 2022 Jun 9.

Department of Pathology Toyama Prefectural Central Hospital Toyama Japan.

We herein report the cases of three patients with chest symptoms or fever and diffuse wall thickening of the trachea and main bronchi on chest CT. They were diagnosed with various causes of inflammations of the trachea and main bronchi using bronchial or tracheal biopsy specimens and flexible bronchoscopy. Read More

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Foreign Body Aspiration Simulating Lung Cancer.

Arch Bronconeumol 2021 Aug;57(8):540

Pulmonology Department, Unidade Local de Saúde da Guarda E.P.E. - Hospital Sousa Martins, Portugal; Faculty of Medicine of the University of Beira Interior, Portugal.

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Core Microbiota in Central Lung Cancer With Streptococcal Enrichment as a Possible Diagnostic Marker.

Arch Bronconeumol 2021 Nov;57(11):681-689

Department of Microbiology, Ramón y Cajal Health Investigation Institute (IRYCIS), Ramón y Cajal University Hospital, Madrid, Spain; University Alfonso X El Sabio, Villanueva de la Cañada, Madrid, Spain.

Background: Dysbiosis in lung cancer has been underexplored. The aim of this study was to define the bacterial and fungal microbiota of the bronchi in central lung cancer and to compare it with that of the oral and intestinal compartments.

Methods: Twenty-five patients with central lung cancer and sixteen controls without antimicrobial intake during the previous month were recruited. Read More

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November 2021

Bronchial and Tracheal Mucosa-Associated Lymphoid Tissue Lymphoma.

Arch Bronconeumol 2021 Dec 1;57(12):767. Epub 2021 Dec 1.

Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Electronic address:

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December 2021

Tracheobronchial Laceration After Blunt Chest Trauma.

Arch Bronconeumol 2021 Jul 18;57(7):490. Epub 2021 May 18.

Servicio de Radiología, Área Clínica de Imagen Médica, Hospital Universitari i Politècnic La Fe, Valencia, Spain.

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Cigarette Smoke Extract Disturbs Mitochondria-Regulated Airway Epithelial Cell Responses to Pneumococci.

Cells 2022 May 28;11(11). Epub 2022 May 28.

Infection Immunology Group, Institute of Medical Microbiology, Infection Control and Prevention, Health Campus Immunology, Infectiology and Inflammation, Otto-von-Guericke University, 39120 Magdeburg, Germany.

Mitochondrial functionality is crucial for the execution of physiologic functions of metabolically active cells in the respiratory tract including airway epithelial cells (AECs). Cigarette smoke is known to impair mitochondrial function in AECs. However, the potential contribution of mitochondrial dysfunction in AECs to airway infection and airway epithelial barrier dysfunction is unknown. Read More

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Comparisons of the segments of left-sided double-lumen tracheobronchial tubes as industrial products.

BMC Anesthesiol 2022 Jun 8;22(1):177. Epub 2022 Jun 8.

Department of Anesthesia, Shonan Kamakura General Hospital, Kanagawa, 247-8533, Japan.

Background: Although there are at least seven manufacturers producing left-sided double-lumen tubes (DLTs), there have been few reports comparing the segments of these DLTs. In this study, we compared various segments of left-sided DLTs further.

Materials And Methods: We examined five manufacturers' left-sided DLTs: Mallinckrodt, Portex, Rüsch, Sheridan, and Daiken-medical. Read More

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Tracheobronchoplasty for tracheobronchomalacia.

J Vis Surg 2022 20;8. Epub 2022 Apr 20.

Department of Surgery, Lifespan Health System Hospitals, Warren Alpert Medical School, Brown University, Providence, RI, USA.

Tracheobronchoplasty (TBP) consists of splinting of the posterior membranous wall of the central airways with the goal of restoring a normal configuration and preventing excessive collapse in patients with tracheobronchomalacia (TBM). Despite some variation in technique, it consists of sewing a mesh on the posterior membranous wall of the trachea and both main stem bronchi. Traditionally performed through a right posterolateral thoracotomy, it should be reserved for cases of severe TBM. Read More

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KCa3.1 differentially regulates trachea and bronchi epithelial gene expression in a chronic-asthma mouse model.

Physiol Genomics 2022 Jun 6. Epub 2022 Jun 6.

Centro de Estudios Científicos, Valdivia, Los Rios, Chile.

Ion channels are potentially exploitable as pharmacological targets to treat asthma. This study evaluated the role of KCa3.1 channels, encoded by Kcnn4, in regulating the gene expression of mouse airway epithelium and the development of asthma traits. Read More

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[Annual review of bronchiectasis in 2021].

Zhonghua Jie He He Hu Xi Za Zhi 2022 Jun;45(6):592-597

Department of Respiratory and Critical Care Medicine, Institute of Respiratory Medicine, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China.

Bronchiectasis, a common chronic respiratory disease, is characterized by irreversible and abnormal bronchial dilatation due to multiple causes. In 2021, a series of significant research progress have been made in bronchiectasis, focusing on the mechanism, diagnosis, clinical phenotypes, treatment, comorbidities, . Several studies have shown that many mediators are involved in the pathogenesis of bronchiectasis, such as lipids, platelets, and respiratory microorganisms, providing new insights into the development of prevention and therapy targets of bronchiectasis. Read More

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[Chronic obstructive pulmonary disease. A chronic inflammatory disease].

Rev Med Liege 2022 May;77(5-6):295-301

Service de Pneumologie, CHU Liège, Belgique.

Chronic Obstructive Pulmonary Disease (COPD) is a disease caused by a chronic inflammatory response induced by the inhalation of cigarette smoke or toxic particles/gases in the airways. However, we actually know that COPD is a disease that does not only induce inflammation in lung parenchyma and bronchi, but also provokes systemic inflammation which plays a role in multiple comorbidities. Thereby, treatment of COPD should not only focus on the bronchi to relieve symptoms, improve respiratory function and reduce the rate of exacerbations, but must also be extended to the systemic effects of the disease. Read More

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Algebraic approximation of the distributed model for the pressure drop in the respiratory airways.

Adam G Polak

Int J Numer Method Biomed Eng 2022 Jun 1:e3632. Epub 2022 Jun 1.

Department of Electronic and Photonic Metrology, Faculty of Electronics, Photonics and Microsystems, Wrocław University of Science and Technology, Wrocław, Poland.

The complexity of the human respiratory system causes that one of the main methods of analyzing the dynamic pulmonary phenomena and interpreting experimental results are simulations of its computational models. Among the most compound elements of these models, apart from the bronchial tree structure, is the phenomenon of flow limitation in flexible bronchi, which causes them to collapse with increasing flow, thus their properties, such as resistance, compliance and inertance, are highly nonlinear and time-varying. Commonly, this phenomenon is ignored, or a distributed model for the airway pressure drop is applied, simulated with a modified numerical solver of this differential equation (ODE). Read More

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Lung ultrasound is non-inferior to bronchoscopy for confirmation of double-lumen endotracheal tube positioning: a randomized controlled noninferiority study.

BMC Anesthesiol 2022 May 30;22(1):168. Epub 2022 May 30.

Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Background: Appropriate placement of left-sided double-lumen endotracheal tubes (LDLTs) is paramount for optimal visualization of the operative field during thoracic surgeries that require single lung ventilation. Appropriate placement of LDLTs is therefore confirmed with fiberoptic bronchoscopy (FOB) rather than clinical assessment alone. Recent studies have demonstrated lung ultrasound (US) is superior to clinical assessment alone for confirming placement of LDLT, but no large trials have compared US to the gold standard of FOB. Read More

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Cell response analysis in SARS-CoV-2 infected bronchial organoids.

Commun Biol 2022 05 30;5(1):516. Epub 2022 May 30.

Center for iPS Cell Research and Application (CiRA), Kyoto University, Kyoto, 606-8507, Japan.

The development of an in vitro cell model that can be used to study severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) research is expected. Here we conducted infection experiments in bronchial organoids (BO) and an BO-derived air-liquid interface model (BO-ALI) using 8 SARS-CoV-2 variants. The infection efficiency in BO-ALI was more than 1,000 times higher than that in BO. Read More

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A Novel In Vivo Model of Laryngeal Papillomavirus-Associated Disease Using Papillomavirus.

Viruses 2022 05 8;14(5). Epub 2022 May 8.

Department of Surgery, University of Wisconsin-Madison, Madison, WI 53705, USA.

Recurrent respiratory papillomatosis (RRP), caused by laryngeal infection with low-risk human papillomaviruses, has devastating effects on vocal communication and quality of life. Factors in RRP onset, other than viral presence in the airway, are poorly understood. RRP research has been stalled by limited preclinical models. Read More

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BGZLS10-17 and BGPKM22 Exhibit Anti-Inflammatory Effect by Attenuation of NF-κB and MAPK Signaling in Human Bronchial Epithelial Cells.

Int J Mol Sci 2022 May 16;23(10). Epub 2022 May 16.

Laboratory for Molecular Microbiology, Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, 11042 Belgrade, Serbia.

Bronchial epithelial cells are exposed to environmental influences, microbiota, and pathogens and also serve as a powerful effector that initiate and propagate inflammation by the release of pro-inflammatory mediators. Recent studies suggested that lung microbiota differ between inflammatory lung diseases and healthy lungs implicating their contribution in the modulation of lung immunity. Lactic acid bacteria (LAB) are natural inhabitants of healthy human lungs and also possess immunomodulatory effects, but so far, there are no studies investigating their anti-inflammatory potential in respiratory cells. Read More

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Shell Disorder Models Detect That Omicron Has Harder Shells with Attenuation but Is Not a Descendant of the Wuhan-Hu-1 SARS-CoV-2.

Biomolecules 2022 Apr 25;12(5). Epub 2022 Apr 25.

Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.

Before the SARS-CoV-2 Omicron variant emergence, shell disorder models (SDM) suggested that an attenuated precursor from pangolins may have entered humans in 2017 or earlier. This was based on a shell disorder analysis of SARS-CoV-1/2 and pangolin-Cov-2017. The SDM suggests that Omicron is attenuated with almost identical N (inner shell) disorder as pangolin-CoV-2017 (N-PID (percentage of intrinsic disorder): 44. Read More

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New Insight in Histamine Functions.

Biomolecules 2022 Apr 19;12(5). Epub 2022 Apr 19.

Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology, University of Florence, Viale Gaetano Pieraccini, 6, 50139 Florence, Italy.

The first properties of histamine (HA) that were elucidated were vasodilation and contraction of smooth muscles in the gut after stimulating gastric acid secretion and constriction of the bronchial area during anaphylaxis [... Read More

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Acute airway obstruction by a mucus plug in a patient with a 12-year history of inserting a double cannula tracheostomy tube: A case report.

SAGE Open Med Case Rep 2022 20;10:2050313X221100874. Epub 2022 May 20.

Department of Family Medicine, Medical Center for the Entire Family, Keiju Medical Center, Nanao, Japan.

Acute airway obstruction long after tracheostomy has rarely been reported. An 81-year-old Japanese woman with a tracheostomy tube for 12 years developed a 2-day history of coughing-up sputum with difficulty, foreign body sensation, and mild dyspnea. Dyspnea worsened immediately after computed tomography, showing soft tissue opacity between the tip of the tracheostomy tube and the bronchi. Read More

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An Accessory Cardiac Bronchus Was Identified During Double-Lumen Tube Position Verification with Flexible Bronchoscopy.

J Cardiothorac Vasc Anesth 2022 Aug 7;36(8 Pt B):3431-3432. Epub 2022 May 7.

Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address:

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Quality over quantity: the importance of collecting relevant samples to understand complex diseases.

Eur Respir J 2022 May 26;59(5). Epub 2022 May 26.

University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, The Netherlands.

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