264 results match your criteria Broad Ligament Disorders


Rare giant female adnexal tumor of probable Wolffian origin: a case report.

J Surg Case Rep 2022 May 27;2022(5):rjac243. Epub 2022 May 27.

Department of Surgery, General Hospital, Sarajevo 71 000, Bosnia and Herzegovina.

Female adnexal tumors of probable Wolffian origin (FATWOs) are extremely rare tumors, with only around 100 cases published worldwide. FATWOs are most frequently found in the broad ligament, but these can also appear in the mesosalpinx, Fallopian tube, ovary, paravaginal region or peritoneum. We present a case of a 68-year-old female with a history of painless abdominal distension and frequent urination, with palpable big abdominal mass. Read More

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Multi-photonic Adjunctive Therapy for the Management of Periodontitis: Recent Advances and New Treatment Approach.

Adv Exp Med Biol 2022 ;1373:341-352

Department of Experimental and Clinical Medicine, Research Unit of Histology & Embryology, University of Florence, Florence, Italy.

The efficacy of photonic therapy adjunctive to conventional root cleansing procedures for the treatment of chronic periodontitis is matter of controversy. The meta-analyses of the clinical data available in the literature have failed to reach univocal conclusions because of broad variability among the applied photonic treatments, different in terms of light-emitting devices (laser or LED), wavelengths, irradiation power and modes, clinical indications, disease grading, follow-up times, and results assessment. Hovever, this complexity can also favour a different interpretation, which assigns a specific role to each photonic treatments in order to improve the outcome of the conventional treatments, in terms of reduction of periodontopathogenic bacteria and local inflammation, and increased regeneration of alveolar bone, periodontal ligament and gingiva. Read More

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Comparison of conventional ligatures and a vessel sealing device for haemostasis during open ovariohysterectomy in rabbits.

N Z Vet J 2022 Jun 13:1-7. Epub 2022 Jun 13.

Centre Hospitalier Vétérinaire Saint Martin, Bellevue, France.

Aims: To compare surgical times and rates of intra-operative and post-operative complications for open ovariohysterectomy (OVH) in female rabbits using conventional ligatures or a vessel sealing device (VSD) for haemostasis.

Methods: Female pet rabbits (n = 23) presented for OVH for either desexing or treatment of reproductive disorders were randomly assigned to a conventional ligatures (CL) group (n = 12) or a LigaSure 5-mm (LS5) group (n = 11). In the CL group, the ovarian pedicles were ligated with a single surgeon's knot. Read More

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Bowel Obstruction Caused by Broad Ligament Hernia Successfully Repaired by Laparoscopy in an Elderly Patient: A Case Report.

Cureus 2022 Mar 16;14(3):e23237. Epub 2022 Mar 16.

Department of Radiology, Al-Adan Hospital, Kuwait, KWT.

The most common causes of small bowel obstruction (SBO) are adhesions, Crohn's disease, neoplasms, and hernias. Internal hernias are rare, and they occur when the small bowel herniates through a defect in the abdominal cavity. The occurrence of internal hernias due to a broad ligament defect is very rare and accounts for 4%-7% of cases of internal hernia. Read More

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Management recommendations for pancreatic manifestations of von Hippel-Lindau disease.

Cancer 2022 02 4;128(3):435-446. Epub 2021 Nov 4.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Von Hippel-Lindau disease (VHL) is a multineoplasm inherited disease manifesting with hemangioblastoma of the central nervous system and retina, adrenal pheochromocytoma, renal cell carcinoma, pancreatic neuroendocrine tumors and cysts, and neoplasms/cysts of the ear, broad ligament, and testicles. During 2018-2020, the VHL Alliance gathered several committees of experts in the various clinical manifestations of VHL to review the literature, gather the available evidence on VHL, and develop recommendations for patient management. The current report details the results of the discussion of a group of experts in the pancreatic manifestations of VHL along with their proposed recommendations for the clinical surveillance and management of patients with VHL. Read More

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February 2022

Primary uterine broad ligament ependymoma with CHEK2 p.H371Y germline mutation: A CARE-compliant case report uterine broad ligament ependymoma.

J Obstet Gynaecol Res 2022 Jan 30;48(1):266-270. Epub 2021 Oct 30.

Department of Oncology, The First Hospital of Jilin University, Jilin, China.

Ependymomas arise from ependymal cells lining the ventricles and central canal of the spinal cord and can occur throughout the whole neuraxis. The lesion rarely occurs in extracranial or extraspinal regions, particularly in the uterine broad ligament. Thus, for the pathogenesis of nonsacral extra-central nervous system (CNS) ependymomas remains elusive. Read More

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January 2022

Umbilical Cord Mesenchymal Stem Cell Therapy for Regenerative Treatment of Rheumatoid Arthritis: Opportunities and Challenges.

Drug Des Devel Ther 2021 15;15:3927-3936. Epub 2021 Sep 15.

Faculty of Health Sciences, University of Macau, Macau, People's Republic of China.

Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology with a high rate of disability. Traditional treatments for RA remain a challenging issue. For example, nonsteroidal anti-inflammatory drugs (NSAIDs) have no therapeutic effects on joint destruction, and the prominent side effects include gastrointestinal symptoms. Read More

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January 2022

Covid no-related surgical emergencies during Covid-19 time. Case report: broad ligament internal hernia with associated small bowel necrosis.

Cir Esp (Engl Ed) 2021 Aug-Sep;99(7):547-549. Epub 2021 Feb 6.

Departamento de Cirugía General y Visceral, Centro Hospitalario de Luxemburgo, Luxembourg, Luxembourg.

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Intravenous leiomyomatosis: Case series and review of the literature.

Int J Surg Case Rep 2021 Aug 31;85:106257. Epub 2021 Jul 31.

Department of Gynaecological Surgery, Hospital de Sion, Avenue du Grand-Champsec 80, 1951 Sion, Switzerland; Department of Obstetrics and Gynecology, Hôpitaux Universitaires de Genève (HUG), Rue Gabrielle-Perret-Gentil 4, 1205 Genève, Switzerland.

Introduction: Intravenous leiomyomatosis (ILV) is a rare pathology, part of leiomyoma beyond the uterus (LBU), characterized by benign smooth muscle cell tumor outside of the uterus and mainly affecting premenopausal woman with a medical history of leiomyoma or gynecologic surgical treatment. The treatment depends on the localization of the tumor, age of the patient, initial size, symptoms and the suitability for surgery but should always aims in toto surgical resection.

Case Presentation: Retrospective case series and review of literature. Read More

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Recurrent and metastatic female adnexal tumor of probable Wolffian origin: A case report and review of the literature.

Medicine (Baltimore) 2021 Apr;100(13):e25377

Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University.

Rationale: Female adnexal tumors of probable Wolffian origin (FATWOs) are rare gynecologic neoplasms arising from the mesonephric duct remnants. Less than 90 cases have been reported in the English literature. Although most cases of FATWO are considered benign, recurrence and metastasis may occur in very few cases during the course of the disease. Read More

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Comprehensive characterization of Alu-mediated breakpoints in germline VHL gene deletions and rearrangements in patients from 71 VHL families.

Hum Mutat 2021 05 19;42(5):520-529. Epub 2021 Mar 19.

Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Von Hippel-Lindau (VHL) is a hereditary multisystem disorder caused by germline alterations in the VHL gene. VHL patients are at risk for benign as well as malignant lesions in multiple organs including kidney, adrenal, pancreas, the central nervous system, retina, endolymphatic sac of the ear, epididymis, and broad ligament. An estimated 30%-35% of all families with VHL inherit a germline deletion of one, two, or all three exons. Read More

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The subjective knee value is a valid single-item survey to assess knee function in common knee disorders.

Arch Orthop Trauma Surg 2021 Feb 1. Epub 2021 Feb 1.

Center for Musculoskeletal Surgery, Campus Mitte, Charité-Universitaetsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.

Introduction: The patient's perspective plays a key role in judging the effect of knee disorders on physical function. We have introduced the Subjective Knee Value (SKV) to simplify the evaluation of individual's knee function by providing one simple question. The purpose of this prospective study was to validate the SKV with accepted multiple-item knee surveys across patients with orthopaedic knee disorders. Read More

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February 2021

Clinicopathologic features and clinical outcomes of intravenous leiomyomatosis of the uterus: A case series.

Medicine (Baltimore) 2021 Jan;100(1):e24228

Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University.

Rationale: Intravenous leiomyomatosis (IVL) is a rare and special type of smooth muscle tumor originating in the uterus. It is classified as a benign disease according to its histological features but shows the behavioral characteristics of a malignant tumor. It is easily misdiagnosed and recurrent. Read More

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January 2021

Discovery of an endometrioid cancer lymph node metastasis without primary tumor in a context of Lynch syndrome.

J Gynecol Obstet Hum Reprod 2021 Mar 6;50(3):102060. Epub 2021 Jan 6.

Department of Gynaecological and Breast Oncological Surgery, European Georges-Pompidou Hospital, APHP. Centre, France; Paris University, Faculty of Medicine, Paris, France; INSERM UMR-S 1147, Université de Paris, Centre Universitaire des Saints-Pères, Paris, France.

Introduction: Lynch syndrome is a hereditary predisposition to cancers, including colo-rectal and endometrial cancers in women. Prophylactic surgery including hysterectomy and bilateral salpingo-oophorectomy is recommended once the parental project is completed in case of identified mutation.

Case Presentation: We describe the case of a 50-year-old patient with Lynch syndrome and identified MSH6 mutation who underwent a prophylactic hysterectomy with bilateral salpingo-oophorectomy. Read More

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Hereditary ovarian tumour syndromes: current update on genetics and imaging.

Clin Radiol 2021 Apr 19;76(4):313.e15-313.e26. Epub 2021 Jan 19.

Department of Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holocombe Blvd, Houston, TX 77030, USA. Electronic address:

Hereditary ovarian tumour syndromes are a diverse group of hereditary syndromes characterised by the development of specific histotypes of ovarian neoplasms. While BRCA syndromes are exclusively associated with high-grade serous carcinomas, patients with Lynch syndrome show a preponderance of endometrioid subtype of ovarian and endometrial carcinomas. Distinct non-epithelial phenotypes, such as sex cord stromal tumours with annular tubules, Sertoli-Leydig cell tumours, and small cell carcinoma of the hypercalcaemic type occur in patients with Peutz-Jeghers, DICER1, and rhabdoid tumour predisposition syndromes, respectively. Read More

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Primary broad ligament adenocarcinoma.

Autops Case Rep 2020 Sep 2;10(4):e2020176. Epub 2020 Sep 2.

Postgraduate Institute of Medical Education and Research (PGIMER), Department of Pathology. Chandigarh, India.

Primary broad ligament carcinoma is a very rare occurrence with 28 reported cases worldwide, to date. The epidemiology, treatment strategy and prognosis are still uncertain because of the scarcity of cases. Currently, all broad ligament carcinomas are managed similar to epithelial ovarian cancer. Read More

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September 2020

Strangulated internal hernia due to defect in broad ligament: a case report.

J Surg Case Rep 2020 Nov 30;2020(11):rjaa487. Epub 2020 Nov 30.

Grandview Medical Center, Department of Surgery, Dayton, OH, USA.

Small bowel obstruction is a relatively common disease process accounting for up to 16 percent of surgical admissions and more than 300,000 operations annually in the United States. Approximately 5-8 percent of small bowel obstructions can be attributed to internal hernias. A slightly lower percentage, roughly 4-7 percent, of these internal hernias are noted to originate from a defect in the broad ligament of the uterus. Read More

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November 2020

Neck subcutaneous nodule as first metastasis from broad ligament leiomyosarcoma: a case report and review of literature.

BMC Surg 2020 Nov 25;20(1):297. Epub 2020 Nov 25.

Department of Medical, Oral and Biotechnological Sciences, University G. D'Annunzio, Chieti-Pescara, Via dei Vestini, 66100, Chieti, Italy.

Background: Leiomyosarcoma usually develops in the myometrium and is characterized by a high recurrence rate, frequent hematogenous dissemination, and poor prognosis. Metastasis is usually to lungs, liver, and bone, and occasionally to the brain, but seldom to the head and neck region. Primary leiomyosarcoma very rarely arises in the broad ligament. Read More

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November 2020

Recurrence hernia in the broad ligament of the uterus: a case report.

Surg Case Rep 2020 Nov 16;6(1):288. Epub 2020 Nov 16.

Department of Surgery, Saiseikai Sanjo Hospital, Sanjo, Japan.

Background: Bowel herniation through a defect in the broad ligament of the uterus is a rare disease and few cases of recurrence have been reported. We report herein a recurrence case of a patient with broad ligament hernia (BLH), along with a review of the literature.

Case Presentation: A 53-year-old woman complaining of abdominal pain was transported to our hospital. Read More

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November 2020

Molecular analysis of a uterine broad ligament leiomyoma in a patient with CLOVES syndrome.

Pathol Res Pract 2020 Dec 9;216(12):153285. Epub 2020 Nov 9.

Pathology Department, University Hospital of Saint-Etienne, France.

Overgrowth syndromes are characterized by a global or regional excess growth of various tissue types, especially of mesenchymal nature. The CLOVES (Congenital Lipomatous asymmetric Overgrowth of the trunk with lymphatic, capillary, venous, and combined-type Vascular malformations, Epidermal naevi, Scoliosis/Skeletal and spinal anomalies) syndrome is characterized by an asymmetric growth excess associated with PIK3CA mutations, found in mosaic, affecting the lesional, but not the normal tissues. Herein, we report the case of a patient affected by CLOVES syndrome, harboring a 13 cm leiomyoma of the uterine broad ligament. Read More

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December 2020

Effects of Nano-Sulfides on Learning and Memory Abilities and Expression of Related Genes in Cyclic Adenosine Monophosphate-cAMP Response Element Binding-Brain-Derived Neurotrophic Factor Pathway in Rats.

J Nanosci Nanotechnol 2021 02;21(2):1142-1147

Department of Neurological Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou City, 325027, Zhejiang Province, China.

In recent years, with the rapid development of nano-biotechnology and biomedicine, people have provided new ideas and methods for disease diagnosis and treatment. Nano-sulfides with unique two-dimensional structures and special physicochemical properties have begun to be applied to biology and medical field. Relevant research results show that nano-sulfides have good effects in tumor photothermal treatment, multimodal imaging, antitumor drug delivery, biosensors and tissue engineering, showing their potential application value. Read More

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February 2021

Broad ligament Extraintestinal Gastrointestinal Stromal Tumor (EGIST): Case report and brief overview of EGIST.

Gynecol Oncol Rep 2020 Aug 12;33:100622. Epub 2020 Aug 12.

525 East 68th St, Weill Cornell Medical College of Cornell University, New York, NY 10165, USA.

•Highly suspicious pelvic mass may require preoperative biopsy for diagnosis.•Neoadjuvant imatinib lowers EGIST tumor burden in extensive disease preoperatively.•EGIST resection aims at complete surgical resection and negative margins. Read More

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Imaging of the Acromioclavicular Joint: Anatomy, Function, Pathologic Features, and Treatment.

Radiographics 2020 Sep-Oct;40(5):1355-1382. Epub 2020 Aug 7.

From the Institute of Radiology, St. Luke's Medical Center Global City, Department of Radiology, Philippine Orthopedic Center, Maria Clara St, Santa Mesa Heights, Quezon City, Metro Manila, Philippines 1100 (D.V.F.); Division of Musculoskeletal Radiology, Laboratorio Delboni Auriemo, DASA, São Paulo, Brazil (P.K.G.); Department of Musculoskeletal Radiology, Ayudas Diagnósticas Sura, Medellín, Colombia (C.M.G.); Department of Radiology, Clínica Internacional, Lima, Peru (D.F.U.); and Department of Radiology, UCSD Health System, San Diego, Calif (M.N.P.).

The acromioclavicular joint is an important component of the shoulder girdle; it links the axial skeleton with the upper limb. This joint, a planar diarthrodial articulation between the clavicle and the acromion, contains a meniscus-like fibrous disk that is prone to degeneration. The acromioclavicular capsule and ligaments stabilize the joint in the horizontal direction, while the coracoclavicular ligament complex provides vertical stability. Read More

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Criteria for risk stratification of vulvar and vaginal smooth muscle tumors: a follow-up study with application to leiomyoma variants, smooth muscle tumors of uncertain malignant potential, and leiomyosarcomas.

Hum Pathol 2020 09 17;103:83-94. Epub 2020 Jul 17.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA. Electronic address:

Data have shown that uterine diagnostic criteria are universal for smooth muscle tumors (SMTs) originating in the ovary, vulva, vagina, broad ligament, and other supportive connective tissue and that uterine criteria outperform site-specific criteria for vulvar and vaginal SMTs. Classic benign and malignant spindled SMTs were well represented in our recent study comparing uterine and site-specific criteria in vulvovaginal SMTs, but leiomyoma variants and smooth muscle tumors of uncertain malignant potential (STUMPs) were relatively few. Therefore, we evaluated additional leiomyoma variants, STUMPs, and leiomyosarcomas from 17 patients (10 vaginal and 7 vulvar). Read More

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September 2020

Recurrent broad ligament leiomyosarcoma with pancreatic and thigh metastasis: a case report.

BMC Surg 2020 Jun 29;20(1):143. Epub 2020 Jun 29.

School of Medicine, Nankai University, Tianjin, 300071, China.

Background: Leiomyosarcoma (LMS) is an uncommon mesenchymal neoplasm, which infrequently metastasizes to pancreas and thigh. Clinical presentation and imaging findings of metastatic broad ligament LMS are often nonspecific. Complete excision plays an important role in treatment of patients with localized LMS. Read More

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CHEK2 Mutation in Patient with Multiple Endocrine Glands Tumors. Case Report.

Int J Environ Res Public Health 2020 06 18;17(12). Epub 2020 Jun 18.

Department of Gynecological Endocrinology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.

Background: Many studies show the occurrence of several multiple endocrine neoplasia syndromes caused by different mutations, for example, in MEN1 and RET genes. Nevertheless, there are less common mutations causing multiple endocrine glands tumors. Examples of such mutations are CHEK2 gene mutations, causing breast, kidney, gastric, colorectal, prostate, lung, ovarian, and thyroid cancers. Read More

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Malignant extra-ovarian endometriosis: A case series of ten patients and review of the literature.

Aust N Z J Obstet Gynaecol 2020 08 25;60(4):585-591. Epub 2020 May 25.

Epworth Freemasons Victoria Parade, Melbourne, Victoria, Australia.

Background: The malignant transformation of endometriosis within the ovary is a recognised condition. There is less literature surrounding the malignant transformation of extra-ovarian endometriosis (MEOE).

Aims: We report our experience with MEOE in ten patients and present a review of the literature regarding this rare malignancy. Read More

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Novel p.G1344E mutation in is associated with ectopia lentis.

Br J Ophthalmol 2021 03 13;105(3):341-347. Epub 2020 May 13.

Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Background: Ectopia lentis refers to dislocation or subluxation of the crystalline lens. Fibrillin-1, encoded by , is an important microfibrillar structural component that is specifically required for the suspensory ligament of the lens. mutations may cause abnormal structure of microfibrils and has been associated with a broad spectrum of clinical phenotypes. Read More

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Novel molecular cues for dental defects in hypophosphatasia.

Exp Cell Res 2020 07 22;392(2):112026. Epub 2020 Apr 22.

Bernhard-Heine-Center for Locomotion Research, University of Würzburg, Würzburg, Germany. Electronic address:

Mineralization disorders with a broad range of etiological factors represent a huge challenge in dental diagnosis and therapy. Hypophosphatasia (HPP) belongs to the rare diseases affecting predominantly mineralized tissues, bones and teeth, and occurs due to mutations in the ALPL gene, which encodes tissue-nonspecific alkaline phosphatase (TNAP). Here we analyzed stem cells from bone marrow (BMSCs), dental pulp (DPSCs) and periodontal ligament (PDLSCs) in the absence and presence of efficient TNAP inhibitors. Read More

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