251 results match your criteria Broad Ligament Disorders


Recurrent and metastatic female adnexal tumor of probable Wolffian origin: A case report and review of the literature.

Medicine (Baltimore) 2021 Apr;100(13):e25377

Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University.

Rationale: Female adnexal tumors of probable Wolffian origin (FATWOs) are rare gynecologic neoplasms arising from the mesonephric duct remnants. Less than 90 cases have been reported in the English literature. Although most cases of FATWO are considered benign, recurrence and metastasis may occur in very few cases during the course of the disease. Read More

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The subjective knee value is a valid single-item survey to assess knee function in common knee disorders.

Arch Orthop Trauma Surg 2021 Feb 1. Epub 2021 Feb 1.

Center for Musculoskeletal Surgery, Campus Mitte, Charité-Universitaetsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.

Introduction: The patient's perspective plays a key role in judging the effect of knee disorders on physical function. We have introduced the Subjective Knee Value (SKV) to simplify the evaluation of individual's knee function by providing one simple question. The purpose of this prospective study was to validate the SKV with accepted multiple-item knee surveys across patients with orthopaedic knee disorders. Read More

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February 2021

Clinicopathologic features and clinical outcomes of intravenous leiomyomatosis of the uterus: A case series.

Medicine (Baltimore) 2021 Jan;100(1):e24228

Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University.

Rationale: Intravenous leiomyomatosis (IVL) is a rare and special type of smooth muscle tumor originating in the uterus. It is classified as a benign disease according to its histological features but shows the behavioral characteristics of a malignant tumor. It is easily misdiagnosed and recurrent. Read More

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January 2021

Primary broad ligament adenocarcinoma.

Autops Case Rep 2020 Sep 2;10(4):e2020176. Epub 2020 Sep 2.

Postgraduate Institute of Medical Education and Research (PGIMER), Department of Pathology. Chandigarh, India.

Primary broad ligament carcinoma is a very rare occurrence with 28 reported cases worldwide, to date. The epidemiology, treatment strategy and prognosis are still uncertain because of the scarcity of cases. Currently, all broad ligament carcinomas are managed similar to epithelial ovarian cancer. Read More

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September 2020

Strangulated internal hernia due to defect in broad ligament: a case report.

J Surg Case Rep 2020 Nov 30;2020(11):rjaa487. Epub 2020 Nov 30.

Grandview Medical Center, Department of Surgery, Dayton, OH, USA.

Small bowel obstruction is a relatively common disease process accounting for up to 16 percent of surgical admissions and more than 300,000 operations annually in the United States. Approximately 5-8 percent of small bowel obstructions can be attributed to internal hernias. A slightly lower percentage, roughly 4-7 percent, of these internal hernias are noted to originate from a defect in the broad ligament of the uterus. Read More

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November 2020

Neck subcutaneous nodule as first metastasis from broad ligament leiomyosarcoma: a case report and review of literature.

BMC Surg 2020 Nov 25;20(1):297. Epub 2020 Nov 25.

Department of Medical, Oral and Biotechnological Sciences, University G. D'Annunzio, Chieti-Pescara, Via dei Vestini, 66100, Chieti, Italy.

Background: Leiomyosarcoma usually develops in the myometrium and is characterized by a high recurrence rate, frequent hematogenous dissemination, and poor prognosis. Metastasis is usually to lungs, liver, and bone, and occasionally to the brain, but seldom to the head and neck region. Primary leiomyosarcoma very rarely arises in the broad ligament. Read More

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November 2020

Recurrence hernia in the broad ligament of the uterus: a case report.

Surg Case Rep 2020 Nov 16;6(1):288. Epub 2020 Nov 16.

Department of Surgery, Saiseikai Sanjo Hospital, Sanjo, Japan.

Background: Bowel herniation through a defect in the broad ligament of the uterus is a rare disease and few cases of recurrence have been reported. We report herein a recurrence case of a patient with broad ligament hernia (BLH), along with a review of the literature.

Case Presentation: A 53-year-old woman complaining of abdominal pain was transported to our hospital. Read More

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November 2020

Effects of Nano-Sulfides on Learning and Memory Abilities and Expression of Related Genes in Cyclic Adenosine Monophosphate-cAMP Response Element Binding-Brain-Derived Neurotrophic Factor Pathway in Rats.

J Nanosci Nanotechnol 2021 Feb;21(2):1142-1147

Department of Neurological Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou City, 325027, Zhejiang Province, China.

In recent years, with the rapid development of nano-biotechnology and biomedicine, people have provided new ideas and methods for disease diagnosis and treatment. Nano-sulfides with unique two-dimensional structures and special physicochemical properties have begun to be applied to biology and medical field. Relevant research results show that nano-sulfides have good effects in tumor photothermal treatment, multimodal imaging, antitumor drug delivery, biosensors and tissue engineering, showing their potential application value. Read More

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February 2021

Broad ligament Extraintestinal Gastrointestinal Stromal Tumor (EGIST): Case report and brief overview of EGIST.

Gynecol Oncol Rep 2020 Aug 12;33:100622. Epub 2020 Aug 12.

525 East 68th St, Weill Cornell Medical College of Cornell University, New York, NY 10165, USA.

•Highly suspicious pelvic mass may require preoperative biopsy for diagnosis.•Neoadjuvant imatinib lowers EGIST tumor burden in extensive disease preoperatively.•EGIST resection aims at complete surgical resection and negative margins. Read More

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Imaging of the Acromioclavicular Joint: Anatomy, Function, Pathologic Features, and Treatment.

Radiographics 2020 Sep-Oct;40(5):1355-1382. Epub 2020 Aug 7.

From the Institute of Radiology, St. Luke's Medical Center Global City, Department of Radiology, Philippine Orthopedic Center, Maria Clara St, Santa Mesa Heights, Quezon City, Metro Manila, Philippines 1100 (D.V.F.); Division of Musculoskeletal Radiology, Laboratorio Delboni Auriemo, DASA, São Paulo, Brazil (P.K.G.); Department of Musculoskeletal Radiology, Ayudas Diagnósticas Sura, Medellín, Colombia (C.M.G.); Department of Radiology, Clínica Internacional, Lima, Peru (D.F.U.); and Department of Radiology, UCSD Health System, San Diego, Calif (M.N.P.).

The acromioclavicular joint is an important component of the shoulder girdle; it links the axial skeleton with the upper limb. This joint, a planar diarthrodial articulation between the clavicle and the acromion, contains a meniscus-like fibrous disk that is prone to degeneration. The acromioclavicular capsule and ligaments stabilize the joint in the horizontal direction, while the coracoclavicular ligament complex provides vertical stability. Read More

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Criteria for risk stratification of vulvar and vaginal smooth muscle tumors: a follow-up study with application to leiomyoma variants, smooth muscle tumors of uncertain malignant potential, and leiomyosarcomas.

Hum Pathol 2020 09 17;103:83-94. Epub 2020 Jul 17.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA. Electronic address:

Data have shown that uterine diagnostic criteria are universal for smooth muscle tumors (SMTs) originating in the ovary, vulva, vagina, broad ligament, and other supportive connective tissue and that uterine criteria outperform site-specific criteria for vulvar and vaginal SMTs. Classic benign and malignant spindled SMTs were well represented in our recent study comparing uterine and site-specific criteria in vulvovaginal SMTs, but leiomyoma variants and smooth muscle tumors of uncertain malignant potential (STUMPs) were relatively few. Therefore, we evaluated additional leiomyoma variants, STUMPs, and leiomyosarcomas from 17 patients (10 vaginal and 7 vulvar). Read More

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September 2020

Recurrent broad ligament leiomyosarcoma with pancreatic and thigh metastasis: a case report.

BMC Surg 2020 Jun 29;20(1):143. Epub 2020 Jun 29.

School of Medicine, Nankai University, Tianjin, 300071, China.

Background: Leiomyosarcoma (LMS) is an uncommon mesenchymal neoplasm, which infrequently metastasizes to pancreas and thigh. Clinical presentation and imaging findings of metastatic broad ligament LMS are often nonspecific. Complete excision plays an important role in treatment of patients with localized LMS. Read More

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CHEK2 Mutation in Patient with Multiple Endocrine Glands Tumors. Case Report.

Int J Environ Res Public Health 2020 06 18;17(12). Epub 2020 Jun 18.

Department of Gynecological Endocrinology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.

Background: Many studies show the occurrence of several multiple endocrine neoplasia syndromes caused by different mutations, for example, in MEN1 and RET genes. Nevertheless, there are less common mutations causing multiple endocrine glands tumors. Examples of such mutations are CHEK2 gene mutations, causing breast, kidney, gastric, colorectal, prostate, lung, ovarian, and thyroid cancers. Read More

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Malignant extra-ovarian endometriosis: A case series of ten patients and review of the literature.

Aust N Z J Obstet Gynaecol 2020 08 25;60(4):585-591. Epub 2020 May 25.

Epworth Freemasons Victoria Parade, Melbourne, Victoria, Australia.

Background: The malignant transformation of endometriosis within the ovary is a recognised condition. There is less literature surrounding the malignant transformation of extra-ovarian endometriosis (MEOE).

Aims: We report our experience with MEOE in ten patients and present a review of the literature regarding this rare malignancy. Read More

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Novel p.G1344E mutation in is associated with ectopia lentis.

Br J Ophthalmol 2021 Mar 13;105(3):341-347. Epub 2020 May 13.

Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Background: Ectopia lentis refers to dislocation or subluxation of the crystalline lens. Fibrillin-1, encoded by , is an important microfibrillar structural component that is specifically required for the suspensory ligament of the lens. mutations may cause abnormal structure of microfibrils and has been associated with a broad spectrum of clinical phenotypes. Read More

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Novel molecular cues for dental defects in hypophosphatasia.

Exp Cell Res 2020 07 22;392(2):112026. Epub 2020 Apr 22.

Bernhard-Heine-Center for Locomotion Research, University of Würzburg, Würzburg, Germany. Electronic address:

Mineralization disorders with a broad range of etiological factors represent a huge challenge in dental diagnosis and therapy. Hypophosphatasia (HPP) belongs to the rare diseases affecting predominantly mineralized tissues, bones and teeth, and occurs due to mutations in the ALPL gene, which encodes tissue-nonspecific alkaline phosphatase (TNAP). Here we analyzed stem cells from bone marrow (BMSCs), dental pulp (DPSCs) and periodontal ligament (PDLSCs) in the absence and presence of efficient TNAP inhibitors. Read More

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Symptoms in Dilating Venous Disease.

Curr Cardiol Rev 2020 ;16(3):164-172

Department of Cardiology, Istinye University Liv Hospital, Istanbul, Turkey.

Lower extremity venous diseases or insufficiency include clinically deteriorating conditions with morphological and functional alterations of the venous system, including venous hypertension, vascular wall structural abnormality, and venous valvar incompetency in association with an inflammatory process. In fact, the same pathophysiological processes are the main underlying mechanisms of other venous insufficiencies in different vascular territories such as Peripheral Varicose Vein (PVV), varicocele, Pelvic Varicosities or Congestion Syndrome (PCS) and Hemorrhoidal Disease (HD). Regarding the anatomical continuity of lower extremity venous system, urogenital system (pampiniform plexus in male and broad ligament and ovarian veins in female) and anorectal venous system, it is reasonable to expect common symptoms such as pain, burning sensation, pruritis, swelling, which arise directly from the involved tissue itself. Read More

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September 2020

An update on human periapical cyst-mesenchymal stem cells and their potential applications in regenerative medicine.

Mol Biol Rep 2020 Mar 6;47(3):2381-2389. Epub 2020 Feb 6.

Laboratory of Cancer Biology and Molecular Immunology, Faculty of Sciences-I, Lebanese University, Beirut, Lebanon.

The broad clinical applications of Mesenchymal Stem Cells (MSCs) in the regenerative medicine field is attributed to their ability to self-renew and differentiate into multiple cellular lineages. Nowadays, MSCs can be derived from a variety of adult and fetal tissues including bone marrow, adipose tissue, umbilical cord and placenta. The difficulties associated with the isolation of MSCs from certain tissues such as bone marrow promoted the search for alternative tissues which are easily accessible. Read More

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Complicated Allen-Masters syndrome.

Tech Coloproctol 2019 Dec 12;23(12):1187-1188. Epub 2019 Nov 12.

Division of General Surgery, Ospedali Riuniti Marche Nord, Pesaro, Italy.

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December 2019

Female adnexal tumors of probable Wolffian origin: morphological, immunohistochemical, and molecular analysis of 15 cases.

Mod Pathol 2020 04 7;33(4):734-747. Epub 2019 Oct 7.

Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.

Female adnexal tumors of probable Wolffian origin are rare and present a diagnostic challenge due to their morphological and immunohistochemical overlap with more common ovarian and broad ligament entities. We evaluated the morphological, immunohistochemical, and molecular features of 15 tumors of probable Wolffian origin. Patients ranged from 32 to 69 (mean 47) years and tumors from 1. Read More

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Volumetric Cone Beam Computed Tomography for the Assessment of Oral Manifestations in Systemic Sclerosis: Data from an EUSTAR Cohort.

J Clin Med 2019 Oct 4;8(10). Epub 2019 Oct 4.

Grigore T. Popa University of Medicine and Pharmacy, School of Medicine, Department of Rheumatology, Iasi 700115, Romania.

Background Oral health issues are commonly reported in systemic sclerosis (SSc), comprising a broad spectrum of manifestations, e.g., reduced mouth opening, periodontal disease, increased periodontal ligament (PDL) space width, and mandibular resorption. Read More

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October 2019

Performance of PROMIS Computer Adaptive Testing As Compared With Established Instruments for Multiple-Ligament Knee Injuries.

Orthop J Sports Med 2019 Sep 5;7(9):2325967119867419. Epub 2019 Sep 5.

Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Background: The Patient-Reported Outcomes Measurement Information System (PROMIS) computer adaptive testing (CAT) is a patient-reported outcome metric that has been validated for anterior cruciate ligament (ACL) injuries, ACL reconstructions, and meniscal injuries. Thus far, the system has not been validated for multiligament knee injuries. The Multiligament Quality of Life (MLQOL) questionnaire is a validated, disease-specific patient-reported outcome instrument for this population that can serve as a gold standard for validation of the newer PROMIS. Read More

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September 2019

En bloc resection of the external iliac vein along with broad ligament leiomyosarcoma: A case report.

Case Rep Womens Health 2019 Jul 27;23:e00131. Epub 2019 Jun 27.

Birmingham Cancer Research UK Cancer Centre, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B15 2TT, UK.

Outcomes following the excision of the external iliac vein during gynaecological oncology surgery are poorly documented. This is because most gynaecological oncologists consider tumours with vascular involvement inoperable. We describe a patient whose right external iliac vein was transected during the removal of a large broad ligament leiomyosarcoma invading the right external iliac vein. Read More

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High-grade endometrial stromal sarcoma: a retrospective study of factors influencing prognosis.

Cancer Manag Res 2019 17;11:831-837. Epub 2019 Jan 17.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China,

Objectives: The aim of this study was to evaluate the factors associated with progress-free survival (PFS) and overall survival (OS) in patients with high-grade endometrial stromal sarcoma (HG-ESS).

Patients And Methods: A total of 40 patients were enrolled in this study at the Peking Union Medical College Hospital, Beijing, China, from 2006 to 2016. The study retrospectively analyzed clinical and pathological data, and associations of these variables with PFS and OS were evaluated. Read More

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January 2019

Ulnar focal cortical indentation: a progressive, deforming variant of focal fibrocartilaginous dysplasia.

Pediatr Radiol 2019 02 15;49(2):187-195. Epub 2018 Nov 15.

Department of Musculoskeletal Radiology,, Temple University Hospital, 3401 N. Broad St., Philadelphia, PA, 19104, USA.

Background: Focal fibrocartilaginous dysplasia is a rare growth disturbance of bone resulting in deformity. In the ulna, focal fibrocartilaginous dysplasia is particularly rare, and the characteristic fibroligamentous tether can result in progressive deformity with progressive dislocation of the radial head. The fibroligamentous tether is similar in appearance and function to the Vickers ligament seen in Madelung deformity. Read More

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February 2019

Fibroblast growth factor-2 inhibits CD40-mediated periodontal inflammation.

J Cell Physiol 2019 05 28;234(5):7149-7160. Epub 2018 Oct 28.

Department of Periodontology, Osaka University Graduate School of Dentistry, Osaka, Japan.

Fibroblast growth factor-2 (FGF-2) stimulates periodontal regeneration by a broad spectrum of effects on periodontal ligament (PDL) cells, such as proliferation, migration, and production of extracellular matrix. A critical factor in the success of periodontal regeneration is the rapid resolution of inflammatory responses in the tissue. We explored an anti-inflammatory effect of FGF-2 during periodontal regeneration and healing. Read More

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Pancreaticoduodenectomy for the Management of Pancreatic or Duodenal Metastases from Primary Sarcoma.

Anticancer Res 2018 Jul;38(7):4041-4046

Department of Academic Surgery, The Royal Marsden Hospital, London, U.K.

Background/aim: Sarcomas are rare and heterogeneous solid tumours of mesenchymal origin and frequently have an aggressive course. The mainstay of management for localized disease is surgical excision. Following excision there is approximately 30-50% risk of developing distant metastases. Read More

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A robust method for RNA extraction and purification from a single adult mouse tendon.

PeerJ 2018 24;6:e4664. Epub 2018 Apr 24.

Center for Regenerative Medicine, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

Background: Mechanistic understanding of tendon molecular and cellular biology is crucial toward furthering our abilities to design new therapies for tendon and ligament injuries and disease. Recent transcriptomic and epigenomic studies in the field have harnessed the power of mouse genetics to reveal new insights into tendon biology. However, many mouse studies pool tendon tissues or use amplification methods to perform RNA analysis, which can significantly increase the experimental costs and limit the ability to detect changes in expression of low copy transcripts. Read More

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