223,523 results match your criteria Broad Ligament Disorders


Occurrence and levels of micropollutants across environmental and engineered compartments in Austria.

J Environ Manage 2018 Dec 3;232:636-653. Epub 2018 Dec 3.

Institute for Water Quality and Resource Management, TU Wien, Karlsplatz 13/226, 1040, Vienna, Austria.

Occurrence and concentration of a broad spectrum of micropollutants are investigated in Austrian river catchments, namely polycyclic aromatic hydrocarbons (PAHs), polybrominated diphenyl ethers (PBDEs), organotin compounds, perfluoroalkyl acids (PFAAs) and metals. The parallel analysis across multiple environmental and engineered compartments sheds light on the ratio of dissolved and particulate transport and on differences in concentration levels between point and diffuse emission pathways. It is found that some PAHs and organotins are present in rivers, groundwater and bulk deposition at higher concentrations than in municipal wastewater effluents. Read More

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December 2018
1 Read

Epigenetics and meditation.

Authors:
Perla Kaliman

Curr Opin Psychol 2018 Nov 22;28:76-80. Epub 2018 Nov 22.

Faculty of Health Sciences, Universitat Oberta de Catalunya, Av. Tibidabo, 39-43, 08035, Barcelona, Spain; Honorary Fellow, Center for Healthy Minds, University of Wisconsin-Madison, United States. Electronic address:

In the last decade, epigenetics has taken center stage to explain the relationships between stress exposure, health and behavior. Acquired or inherited epigenetic changes modulate gene expression states without modifying the DNA sequence itself, they can be long-lasting, yet, they are potentially reversible. Several studies have explored whether meditation-based interventions can influence gene expression profiles towards healthier directions, identifying candidate genes and biological pathways that seem to be sensitive to contemplative practices. Read More

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November 2018
3 Reads

An affinity peptide exerts antiviral activity by strongly binding nervous necrosis virus to block viral entry.

Fish Shellfish Immunol 2018 Dec 3. Epub 2018 Dec 3.

State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory of Improved Variety Reproduction in Aquatic Economic Animals, School of Life Sciences, Sun Yat-sen University, Guangzhou, China. Electronic address:

Nervous necrosis virus (NNV) causes viral nervous necrosis (VNN), a disease that leads to almost 100% mortality among larvae and juvenile fish, severely affecting the aquaculture industry. VNN vaccines based on inactivated viruses or virus-like particles (VLPs) are unsuitable for fish fry with immature adaptive immune systems. Here, we applied an anti-NNV strategy based on affinity peptides (AFPs). Read More

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December 2018
1 Read

Biased perspectives on formyl peptide receptors.

Biochim Biophys Acta Mol Cell Res 2018 Dec 3. Epub 2018 Dec 3.

Institute of Medical Biochemistry, Center for Molecular Biology of Inflammation, University of Muenster, Von-Esmarch-Str. 56, D-48149 Muenster, Germany; Cluster of Excellence "Cells in Motion", University of Muenster, D-48149 Muenster, Germany. Electronic address:

The innate immune system is the first line of defense against pathogenic threats. For the early pathogen recognition and activation of cell protective mechanisms, germline-encoded pattern recognition receptors (PRRs) detect characteristic and evolutionary conserved pathogen-associated molecular patterns (PAMPs). PRRs are therefore key elements in the innate immune response; in addition, they sense danger-associated molecular patterns (DAMPs) that are released by host cell molecules under pathophysiological conditions. Read More

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December 2018
2 Reads

Physiological Models of Human Neuronal Development and Disease.

Neuron 2018 Dec;100(5):1025-1027

Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address:

Human neural network development occurs at stages inaccessible to longitudinal monitoring. By transplanting human neurons to the adult mouse brain, recent studies explore human neural circuit formation in realistic cellular and physiological environments, establishing new models for human neurodevelopmental disorders. Read More

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December 2018

Multi-light responsive quantum dot sensitized hybrid micromotors with dual-mode propulsion.

Angew Chem Int Ed Engl 2018 Dec 6. Epub 2018 Dec 6.

University of Alcalá, Analytical Chemistry and Chem. Ing., Ctra Madrid-Barcelona km 33,600, 28871, Alcalá de Henares, SPAIN.

CdS quantum dots/C60 tubular micromotors with chemical/multi-light-controlled propulsion and "on-the-fly" acceleration capabilities are described. "In-situ" growth of CdS quantum dots on the outer fullerene layer impart them with light-responsive properties in connection to inner Pt, Pd or MnO2 layers. This is the first time that visible-light is used to drive bubble propelled tubular micromotors. Read More

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December 2018

Immunogenic particles with a broad antigenic spectrum stimulate cytolytic T cells and offer increased protection against EBV infection ex vivo and in mice.

PLoS Pathog 2018 Dec 6;14(12):e1007464. Epub 2018 Dec 6.

German Cancer Research Center (DKFZ) Unit F100, Heidelberg, Germany.

The ubiquitous Epstein-Barr virus (EBV) is the primary cause of infectious mononucleosis and is etiologically linked to the development of several malignancies and autoimmune diseases. EBV has a multifaceted life cycle that comprises virus lytic replication and latency programs. Considering EBV infection holistically, we rationalized that prophylactic EBV vaccines should ideally prime the immune system against lytic and latent proteins. Read More

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December 2018

A comparison of maternal and newborn health services costs in Sindh Pakistan.

PLoS One 2018 6;13(12):e0208299. Epub 2018 Dec 6.

Division of Women & Child Health, Aga Khan University, Karachi, Pakistan.

Pakistani women suffer the highest rate of maternal mortality in South Asia. A lack of comprehensive knowledge about maternal and newborn health (MNH) services costs impedes policy decisions to maximize the benefit from existing, as well as emerging, MNH interventions in Pakistan. We compared MNH service costs at different levels of care. Read More

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December 2018
2 Reads

Human bone marrow contains high levels of extracellular vesicles with a tissue-specific subtype distribution.

PLoS One 2018 6;13(12):e0207950. Epub 2018 Dec 6.

Gynecological Endocrinology and Reproductive Medicine, Medical University Innsbruck, Innsbruck, Austria.

Introduction: Extracellular vesicles (EV) are shed from a broad variety of cells and play an important role in activation of coagulation, cell to cell interaction and transport of membrane components. They are usually measured as circulating EV in peripheral blood (PB) and other body fluids. However, little is known about the distribution, presence and impact of EV and their subpopulations in bone marrow (BM). Read More

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December 2018

Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA-stem.

J Clin Invest 2018 Dec 6. Epub 2018 Dec 6.

Both natural influenza infection and current seasonal influenza vaccines primarily induce neutralising antibody responses against highly diverse epitopes within the "head" of the viral hemagglutinin (HA) protein. There is increasing interest on redirecting immunity towards the more conserved HA-stem or stalk as a means to broaden protective antibody responses. Here we examined HA-stem-specific B cell and T-follicular helper (Tfh) cell responses in the context of influenza infection and immunisation in mouse and monkey models. Read More

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December 2018

The MJA-Lancet Countdown on health and climate change: Australian policy inaction threatens lives.

Med J Aust 2018 Dec;209(11):474

School of Public Health, University of Sydney, Sydney, NSW.

Climate plays an important role in human health and it is well established that climate change can have very significant impacts in this regard. In partnership with The Lancet and the MJA, we present the inaugural Australian Countdown assessment of progress on climate change and health. This comprehensive assessment examines 41 indicators across five broad sections: climate change impacts, exposures and vulnerability; adaptation, planning and resilience for health; mitigation actions and health co-benefits; economics and finance; and public and political engagement. Read More

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December 2018
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Selectivity map for molecular beam epitaxy of advanced III-V quantum nanowire networks.

Nano Lett 2018 Dec 6. Epub 2018 Dec 6.

Selective area growth is a promising technique to enable fabrication of scalable III-V nanowire networks required to test proposals for Majorana-based quantum computing devices. However, the contours of the growth parameter window resulting in selective growth remain undefined. Herein, we present a set of experimental techniques which unambiguously establish the parameter space window resulting in selective III-V nanowire networks growth by molecular beam epitaxy. Read More

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December 2018
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Chlorogenic acid-mediated chemical defense of plants against insect herbivores.

Plant Biol (Stuttg) 2018 Dec 6. Epub 2018 Dec 6.

National Institute of Plant Genome Research (NIPGR), Aruna Asaf Ali Marg, New Delhi, 110067, India.

Chlorogenic acid is one of the most abundant beneficial polyphenols in plants and is well known as nutritional anti-oxidant in plant based foods. Apart from its dietary antioxidant activity, it has been proven to be an efficient defense molecule against a broad range of insect herbivores. In the last two decades, several reports have shown the effectiveness of chlorogenic acid for insect's growth deterrence. Read More

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December 2018
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Metal-Organic Framework Derived Hierarchical Co/C@V2O3 Hollow Spheres as a Thin, Lightweight and High-Efficiency Electromagnetic Wave Absorber.

Chemistry 2018 Dec 6. Epub 2018 Dec 6.

Zhejiang University, School of Materials Science and Engineering, 38 Zheda Road, 310027, Hangzhou, CHINA.

Developing high-efficiency electromagnetic (EM) wave absorbing materials with light weight, thin thickness and wide absorption bandwidth is highly desirable for ever-developing electronic and telecommunication devices. Herein, hierarchical metal-organic framework (MOF)-derived Co/C@V2O3 hollow spheres were designed and synthesized through a facile hydrothermal, precipitation and pyrolysis method. The composite exhibits both excellent impedance matching and light weight due to the rational combination of hollow V2O3 spheres and porous Co/C. Read More

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December 2018

Living Messages from Chemistry Icons: Legacies with Contemporary Relevance.

Chem Rec 2018 Dec 6. Epub 2018 Dec 6.

International Organization for Chemical Sciences in Development, 61 rue de Bruxelles, B-5000, Namur, Belgium.

Beyond individual scientific virtuosity and creativity that leading figures in chemistry have displayed, they have sometimes conveyed wider messages of significance beyond their own professional specialization. They include insights into broader aspects of science, society or the ways of the world. On the other hand, the words, attitudes and actions of eminent chemists from former times have not always presented good models for others to follow, whether judged by their own contemporary or our present standards. Read More

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December 2018
2 Reads

Polygenic risk score identifies associations between sleep duration and diseases determined from an electronic medical record biobank.

Sleep 2018 Dec 5. Epub 2018 Dec 5.

Center for Genomic Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA USA.

Study Objectives: We aimed to detect cross-sectional phenotype and polygenic risk score (PRS) associations between sleep duration and prevalent diseases using the Partners Biobank, a hospital-based cohort study linking electronic medical record (EMR) with genetic information.

Methods: Disease prevalence was determined from EMR, and sleep duration was self-reported. A PRS for sleep duration was derived using 78 previously associated SNPs from GWAS for self-reported sleep duration. Read More

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December 2018

Recent developments in endovascular interventions to sustain vascular access patency in haemodialysis patients.

Nephrol Dial Transplant 2018 Dec 5. Epub 2018 Dec 5.

Department of Nephrology, Patras University Hospital, Patras, Greece.

There is amassed evidence regarding the use of endovascular procedures for the treatment of vascular access stenosis and thrombosis. A review was conducted based on available randomized trials, cohort studies and retrospective analyses published after 2000 on endovascular treatment of dysfunctional and thrombosed vascular access, with an aim to illustrate the available device and procedural options. The use of paclitaxel-coated balloons, cutting balloons and covered stents is described in the field of vascular access stenosis. Read More

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December 2018

Accurate and efficient estimation of small p-values with the cross-entropy method: applications in genomic data analysis.

Bioinformatics 2018 Dec 6. Epub 2018 Dec 6.

Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA.

Motivation: Small p-values are often required to be accurately estimated in large-scale genomic studies for the adjustment of multiple hypothesis tests and the ranking of genomic features based on their statistical significance. For those complicated test statistics whose cumulative distribution functions are analytically intractable, existing methods usually do not work well with small p-values due to lack of accuracy or computational restrictions. We propose a general approach for accurately and efficiently estimating small p-values for a broad range of complicated test statistics based on the principle of the cross-entropy method and Markov chain Monte Carlo sampling techniques. Read More

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December 2018
1 Read

Concurrent Developmental Course of Sleep Problems and Emotional/behavioral Problems in Childhood and Adolescence as Reflected by the Dysregulation Profile.

Sleep 2018 Dec 6. Epub 2018 Dec 6.

Centre and Discipline of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, The University of Western Australia, Perth, WA, Australia.

Objectives: Longitudinal data on the course and relationship of concurrent psychopathology in youth are scarce but are of need for better practical patient care and prevention. This study explores the course of (and relationships over time) between sleep problems and concurrent dimensional difficulties relating to anxiety/depression, attention deficiency and aggressive behaviors in childhood and adolescence. The latter three may jointly form a broad syndrome, the dysregulation profile. Read More

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December 2018

Annotation of the Giardia proteome through structure-based homology and machine learning.

Gigascience 2018 Dec 6. Epub 2018 Dec 6.

Walter & Eliza Hall Institute of Medical Research, Melbourne, Australia.

Background: Large-scale computational prediction of protein structures represents a cost-effective alternative to empirical structure determination with particular promise for non-model organisms and neglected pathogens. Conventional sequence-based tools are insufficient to annotate the genomes of such divergent biological systems. Conversely, protein structure tolerates substantial variation in primary amino acid sequence, and is thus a robust indicator of biochemical function. Read More

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December 2018
2 Reads

New CRISPR-Cas9 vectors for genetic modifications of Bacillus species.

FEMS Microbiol Lett 2018 Dec 6. Epub 2018 Dec 6.

Institut für Industrielle Genetik, Universität Stuttgart, Allmandring 31, 70569 Stuttgart, Germany.

Genetic manipulation is a fundamental procedure for the study of gene and operon functions and new characteristics acquisition. Modern CRISPR-Cas technology allows genome editing more precise and increases the efficiency of transferring mutations in a variety of hard to manipulate organisms. Here, we describe new CRISPR-Cas vectors for genetic modifications in bacillary species. Read More

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December 2018
1 Read

Histones Predate the Split Between Bacteria and Archaea.

Bioinformatics 2018 Dec 6. Epub 2018 Dec 6.

Department of Protein Evolution, Max Planck Institute for Developmental Biology, Tübingen, Germany.

Motivation: Histones form octameric complexes called nucleosomes, which organize the genomic DNA of eukaryotes into chromatin. Each nucleosome comprises two copies each of the histones H2A, H2B, H3, and H4, which share a common ancestry. Although histones were initially thought to be a eukaryotic innovation, the subsequent identification of archaeal homologs led to the notion that histones emerged before the divergence of archaea and eukaryotes. Read More

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December 2018
6 Reads

Visible-light induced decarboxylative C2-alkylation of benzothiazoles with carboxylic acids under metal-free conditions.

Org Biomol Chem 2018 Dec 6. Epub 2018 Dec 6.

Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China. and State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China.

An effective protocol of photoredox catalyzed C2-alkylation of benzothiazoles with aliphatic carboxylic acids was disclosed. In the presence of an acridinium salt as a photocatalyst and air as an oxidant, a wide range of secondary or tertiary aliphatic carboxylic acids were employed as alkylation reagents, providing the desired products in good to excellent yields under mild reaction conditions with a broad substrate scope. Read More

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December 2018

Social behaviour and making attachments: a report from the fifth 'Young Microbiologists Symposium on Microbe Signalling, Organisation and Pathogenesis'.

Microbiology 2018 Dec 6. Epub 2018 Dec 6.

1​Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.

The fifth Young Microbiologists Symposium was held in Queen's University Belfast, Northern Ireland, in late August 2018. The symposium, focused on 'Microbe signalling, organization and pathogenesis', attracted 121 microbiologists from 15 countries. The meeting allowed junior scientists to present their work to a broad audience, and was supported by the European Molecular Biology Organization, the Federation of European Microbiological Societies, the Society of Applied Microbiology, the Biochemical Society and the Microbiology Society. Read More

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December 2018
2 Reads

Impaired Hypoxic Pulmonary Vasoconstriction in a Mouse Model of Leigh Syndrome.

Am J Physiol Lung Cell Mol Physiol 2018 Dec 6. Epub 2018 Dec 6.

Department of Anesthesia, Massachusetts General Hospital, United States.

Hypoxic pulmonary vasoconstriction (HPV) is a physiological vasomotor response that maintains systemic oxygenation by matching perfusion to ventilation during alveolar hypoxia. Although mitochondria appear to play an essential role in HPV, the impact of mitochondrial dysfunction on HPV remains incompletely defined. Mice lacking the mitochondrial complex I (CI) subunit Ndufs4 (Ndufs4-/-) develop a fatal progressive encephalopathy and serve as a model for Leigh syndrome, the most common mitochondrial disease in children. Read More

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December 2018

Heritable phytohormone profiles of poplar genotypes vary in resistance to a galling aphid.

Mol Plant Microbe Interact 2018 Dec 6. Epub 2018 Dec 6.

University of Toledo College of Natural Sciences and Mathematics, 385199, Department of Environmental Sciences, Toledo, Ohio, United States.

Insect galls are highly specialized structures arising from atypical development of plant tissue induced by insects. Galls provide the insect enhanced nutrition and protection against natural enemies and environmental stresses. Galls are essentially plant organs formed by an intimate biochemical interaction between the gall-inducing insect and its host-plant. Read More

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December 2018
2 Reads

Bio-statistical options for Quantitative diet analysis.

J Agric Food Chem 2018 Dec 6. Epub 2018 Dec 6.

Sufficient statistics knowledge is crucial for right scheming of a research plan. The elucidations of results are interpretive only if appropriate statistical methods are applied. Statistical strategies are a particular approach to demonstrate complicated information in broad and explicable conclusions. Read More

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December 2018

Cytometric Micro-Bead Magnetic Suspension Array for High-Throughput Ultra-Sensitive Detection of Aflatoxin B1.

Anal Chem 2018 Dec 6. Epub 2018 Dec 6.

High-throughput and low-cost detection of mycotoxins in complex matrices is becoming increasingly urgent but still challenged for ultra-sensitive analyses. Here we reported a green and practical cytometric micro-bead magnetic suspension array (CBMSA) strategy for rapid and economical detection of aflatoxin B1 (AFB1) in multiple batches of lotus seeds samples. The protocol included the fabrication of the suspension array chips by immobilizing the biotin-modified bovine serum albumin-AFB1 (antigen) onto the surface of streptavidin-coated magnetic micro-beads in a multi-wells array, the indirect immuno-competition of antigen and target of AFB1 in lotus seed samples with the specific antibodies, the rapid magnetic separation regardless complex pretreatment steps, and the ultra-sensitive fluorescence detection of fluorescein isothiocyanate labeled goat anti-mouse immunoglobulin G (FITC-IgG) probes. Read More

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December 2018
2 Reads

Proteins regulating microvesicle biogenesis and multidrug resistance in cancer.

Authors:
J Taylor M Bebawy

Proteomics 2018 Dec 6:e1800165. Epub 2018 Dec 6.

Discipline of Pharmacy, Graduate School of Health, The University of Technology Sydney, Sydney, Australia.

Microvesicles (MV) are emerging as important mediators of intercellular communication. These signalling vectors are implicated in physiological processes ranging from vascular homeostasis to inflammation. They also play an important role in the cancer pathology and progression. Read More

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December 2018
1 Read

Directed Evolution Empowered Redesign of Natural Proteins for the Sustainable Production of Chemicals and Pharmaceuticals.

Angew Chem Int Ed Engl 2018 Dec 6. Epub 2018 Dec 6.

ABBt-Institute of Biotechnology, RWTH Aachen University and DWI Leibniz Institute for, Interactive Materials, Worringer Weg 3, 52074, Aachen, Germany.

Directed evolution has advanced into a standard industrial "tool" to tailor naturally occurring proteins for a variety of biotechnological applications, thus enabling product valorization and bringing societal benefits across industrial sectors. Examples are sustainable enzymatic production processes for chemicals, pharmaceuticals, or applications in the food, feed, and laundry industries. In essence, directed evolution has contributed to sustainable industrial processes that fuel the transition from a fossil-based economy to a biobased economy utilizing renewable resources. Read More

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December 2018

miR-342-5p as a potential regulator of HER2 breast cancer cell growth.

Microrna 2018 Dec 6. Epub 2018 Dec 6.

Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, The Norwegian Radium Hospital, Oslo. Norway.

HER2 positive breast cancers (BC) have aggressive behavior and poor prognosis. Previously, we have identified miR-342-5p as an upstream regulator of HER2 signaling, as well as inhibitor of HER2 positive BC cell line growth. Here, we aimed to further investigate the molecular mechanisms behind miR-342-5p-induced HER2 pathway deregulation. Read More

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December 2018
1 Read

Synthesis of Amides by Mild Palladium-Catalyzed Aminocarbonylation of Arylsilanes with Amines Enabled by Copper(II) Fluoride.

J Org Chem 2018 Dec 6. Epub 2018 Dec 6.

A general Pd-catalyzed synthesis of amides by oxidative aminocarbonylation of arylsilanes under mild conditions has been accomplished for the first time. The reaction is promoted by a commercially available copper(II) fluoride, which acts as a dual silane activator and mild oxidant, enabling highly efficient aminocarbonylation of versatile arylsilanes at atmospheric CO pressure. The reaction is tolerant of a wide range of arylsilanes and various sensitive halide functional groups, as well as a broad scope of amines are compatible with this oxidative process using cheap CO. Read More

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December 2018
2 Reads

Improvements in Lipid Suppression for 1H NMR-based Metabolomics: Applications to Solution-state and HR-MAS NMR-natural and in vivo samples.

Magn Reson Chem 2018 Dec 5. Epub 2018 Dec 5.

Environmental NMR Centre, Dept. of Physical and Environmental Sciences, University of Toronto, Scarborough, 1265 Military Trail, Toronto, ON, Canada, M1C 1A4.

Proton NMR spectra of intact biological samples often show strong contributions from lipids which overlap with signals of interest from small metabolites. Pioneering work by Diserens et al. demonstrated that the relative differences in diffusivity and relaxation of lipids verses small metabolites could be exploited to suppress lipid signals, in HR-MAS NMR spectroscopy. Read More

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December 2018
1 Read

VII. MATERNAL SECURE BASE SCRIPT KNOWLEDGE AND JUDGMENTS OF MOTHER-CHILD INTERACTIONS.

Monogr Soc Res Child Dev 2018 Dec;83(4):106-120

Previous studies have shown that mothers with high script scores are better at providing secure base support in naturalistic settings. In the current study, we examine whether maternal script knowledge guides mothers' expectations and judgments of mother-child interactions, providing a bridge between their knowledge and behavior. Forty mothers were asked to use a new Parental Secure Base Q-set designed to characterize a typical mother-child play day at a park. Read More

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December 2018
1 Read

Hepatocyte Nuclear Factor 4 alpha (HNF4α) Activation is Essential for Termination of Liver Regeneration.

Hepatology 2018 Dec 5. Epub 2018 Dec 5.

Department of Pharmacology, Toxicology and Therapeutics.

Hepatocyte Nuclear Factor 4 alpha (HNF4α) is critical for hepatic differentiation. Recent studies have highlighted its role in inhibition of hepatocyte proliferation and tumor suppression. However, the role of HNF4α in liver regeneration is not known. Read More

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December 2018
1 Read

Phase I/II study of dasatinib and exploratory genomic analysis in relapsed or refractory non-Hodgkin lymphoma.

Br J Haematol 2018 Dec 5. Epub 2018 Dec 5.

Division of Oncology & Hematology, University of Nebraska Medical Center, Omaha, NE, USA.

Relapsed or refractory non-Hodgkin lymphomas (NHLs) often carry poor prognosis and pose management challenges. We evaluated the safety and efficacy of dasatinib, a broad-spectrum multi-kinase inhibitor in relapsed/refractory NHL with correlative genomic analysis in a Phase I/II trial. The study included 33 patients with various sub-types of NHL who had received at least one prior therapy. Read More

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December 2018
5 Reads

Multilevel diffusion tensor imaging classification technique for characterizing neurobehavioral disorders.

Brain Imaging Behav 2018 Dec 5. Epub 2018 Dec 5.

Institute for Biological and Medical Engineering, Schools of Engineering, Biology and Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

This proposed novel method consists of three levels of analyses of diffusion tensor imaging data: 1) voxel level analysis of fractional anisotropy of white matter tracks, 2) connection level analysis, based on fiber tracks between specific brain regions, and 3) network level analysis, based connections among multiple brain regions. Machine-learning techniques of (Fisher score) feature selection, (Support Vector Machine) pattern classification, and (Leave-one-out) cross-validation are performed, for recognition of the neural connectivity patterns for diagnostic purposes. For validation proposes, this multilevel approach achieved an average classification accuracy of 90% between Alzheimer's disease and healthy controls, 83% between Alzheimer's disease and mild cognitive impairment, and 83% between mild cognitive impairment and healthy controls. Read More

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December 2018
2 Reads

Computational Analyses Connect Small-Molecule Sensitivity to Cellular Features Using Large Panels of Cancer Cell Lines.

Methods Mol Biol 2019 ;1888:233-254

Chemical Biology and Therapeutics Science Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.

We recently pioneered several analyses of small-molecule sensitivity data collected from large-scale perturbation of hundreds of cancer cell lines with hundreds of small molecules, with cell viability measured as a readout of compound sensitivity. We performed these studies using cancer cell lines previously annotated with cellular, genomic, and basal gene-expression features. By combining small-molecule sensitivity data with these other datasets, we identified new candidate biomarkers of sensitivity, gained insights into small-molecule mechanisms of action, and proposed candidate hypotheses for cancer dependencies (including candidate combination therapies). Read More

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January 2019
1 Read

Opioid Use is Associated with Higher Severity-Adjusted Episode Costs in Patients with Conservatively Managed Degenerative Joint Disease of the Back and Neck.

Pharmacoeconomics 2018 Dec 6. Epub 2018 Dec 6.

Clinical Data Services and Analytics, UnitedHealthcare, 9700 Health Care Lane, Minnetonka, MN, 55343, USA.

Background: Opioid use and misuse are urgent health issues. Previous studies suggest that opioid use increases healthcare resource use but severity adjustment is lacking.

Objective: The objective of this study was to evaluate the severity-adjusted cost difference between opioid users and non-users among patients with conservatively managed degenerative joint disease of the spine within a large commercial health plan population in the United States. Read More

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December 2018
1 Read

Divergent evolution of rice blast resistance Pi54 locus in the genus Oryza.

Rice (N Y) 2018 Dec 5;11(1):63. Epub 2018 Dec 5.

Graduate School of Life Sciences, Tohoku University, Sendai, 980-8577, Japan.

Background: The rice blast resistance gene Pi54 was cloned from Oryza sativa ssp. indica cv. Tetep, which conferred broad-spectrum resistance against Magnaporthe oryzae. Read More

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December 2018
2 Reads

Rapid identification of specific DNA aptamers precisely targeting CD33 positive leukemia cells through a paired cell-based approach.

Biomater Sci 2018 Dec 6. Epub 2018 Dec 6.

Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310058, P.R. China and Department of Toxicology, School of Medicine and Public Health, Zhejiang University, Hangzhou 310058, P.R. China.

Aptamers are short single-stranded DNA or RNA molecules, which have recently been developed for potential broad applications such as clinical therapeutics, diagnosis and tumor-targeted drug delivery. However, the selection of specific aptamers is often unsatisfactory using the classical protein or cell-based SELEX. Herein, we modified the paired cell line approach to identify aptamers targeting leukemia cells expressing the CD33 antigen. Read More

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December 2018

The Effect of Vitamin E and Metallothionein on the Antioxidant Capacities of Cadmium-Damaged Liver in Grass Carp .

Biomed Res Int 2018 4;2018:7935396. Epub 2018 Nov 4.

Department of Aquaculture, College of Animal Science & Technology, Sichuan Agricultural University, WenJiang 611130, Sichuan, China.

Cadmium (Cd) causes a broad spectrum of toxicological effects to animals. Aquatic animals were more likely to accumulate Cd than terrestrial animals because of the living environment. Clearance of Cd in aquatic animals has become an important part of aquatic food safety. Read More

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November 2018

Synergistic interaction between the agonism of cebranopadol at nociceptin/orphanin FQ and classical opioid receptors in the rat spinal nerve ligation model.

Pharmacol Res Perspect 2018 Dec 28;6(6):e00444. Epub 2018 Nov 28.

Translational Science and Intelligence Grünenthal GmbH Aachen Germany.

Cebranopadol (trans-6'-fluoro-4',9'-dihydro--dimethyl-4-phenyl-spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-amine) is a novel analgesic nociceptin/orphanin FQ opioid peptide (NOP) and classical opioid receptor (MOP, DOP, and KOP) agonist with highly efficacious and potent activity in a broad range of rodent models of nociceptive, inflammatory, and neuropathic pain as well as limited opioid-type side effects such as respiratory depression. This study was designed to explore contribution and interaction of NOP and classical opioid receptor agonist components to cebranopadol analgesia in the rat spinal nerve ligation (SNL) model. Assessing antihypersensitive activity in SNL rats intraperitoneal (IP) administration of cebranopadol resulted in ED values of 3. Read More

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December 2018
1 Read