161,735 results match your criteria British journal of psychology London England : 1953[Journal]


Moderate-intensity exercise and high-intensity interval training affect insulin sensitivity similarly in obese adults.

J Clin Endocrinol Metab 2020 Jun 3. Epub 2020 Jun 3.

Substrate Metabolism Laboratory, School of Kinesiology, University of Michigan, USA.

Objective: We compared the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on insulin sensitivity and other important metabolic adaptations in adults with obesity.

Methods: Thirty-one inactive adults with obesity (age: 31±6 years, BMI: 33±3 kg/m2) completed 12 weeks (4 sessions/week) of either HIIT (10x1-minute at 90%HRmax, 1-minute active recovery; n=16) or MICT (45 minutes at 70%HRmax; n=15). To assess the direct effects of exercise independent of weight/fat loss, participants were required to maintain body mass. Read More

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http://dx.doi.org/10.1210/clinem/dgaa345DOI Listing

Digest.

J Sport Exerc Psychol 2020 Jun 3:1-4. Epub 2020 Jun 3.

California State University, Fullerton, USA.

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http://dx.doi.org/10.1123/jsep.2020-0091DOI Listing

The association between obesity and poor outcome after COVID-19 indicates a potential therapeutic role for montelukast.

Med Hypotheses 2020 May 27;143:109883. Epub 2020 May 27.

President British Obesity and Metabolic Surgery Society, Visiting Professor University of Chester, CEO Phoenix Health, United Kingdom. Electronic address:

It is widely believed that infection with the SARS-CoV-2 virus triggers a disproportionate immune response which causes a devastating systemic injury, particularly in individuals with obesity, itself a chronic, multi-organ inflammatory disease. Immune cells accumulate in visceral adipose tissue and together with paracrine adipocytes release a wide range of biologically active cytokines (including IL-1β, IL5, IL6 and IL8) that can result in both local, pulmonary and systemic inflammation. A more intense 'cytokine storm' is postulated as the mechanism behind the extreme immune response seen in severe COVID-19. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.109883DOI Listing

Multiple Sequence Variants in STAC3 Affect Interactions with Ca1.1 and Excitation-Contraction Coupling.

Structure 2020 May 27. Epub 2020 May 27.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address:

STAC3 is a soluble protein essential for skeletal muscle excitation-contraction (EC) coupling. Through its tandem SH3 domains, it interacts with the cytosolic II-III loop of the skeletal muscle voltage-gated calcium channel. STAC3 is the target for a mutation (W284S) that causes Native American myopathy, but multiple other sequence variants have been reported. Read More

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http://dx.doi.org/10.1016/j.str.2020.05.005DOI Listing

Exercise Electrocardiography and Computed Tomography Coronary Angiography for Patients With Suspected Stable Angina Pectoris: A Post Hoc Analysis of the Randomized SCOT-HEART Trial.

JAMA Cardiol 2020 Jun 3. Epub 2020 Jun 3.

British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.

Importance: Recent European guidance supports a diminished role for exercise electrocardiography (ECG) in the assessment of suspected stable angina.

Objective: To evaluate the utility of exercise ECG in contemporary practice and assess the value of combined functional and anatomical testing.

Design, Setting, And Participants: This is a post hoc analysis of the Scottish Computed Tomography of the Heart (SCOT-HEART) open-label randomized clinical trial, conducted in 12 cardiology chest pain clinics across Scotland for patients with suspected angina secondary to coronary heart disease. Read More

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http://dx.doi.org/10.1001/jamacardio.2020.1567DOI Listing

HIV-1 variants are archived throughout infection and persist in the reservoir.

PLoS Pathog 2020 Jun 3;16(6):e1008378. Epub 2020 Jun 3.

Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America.

The HIV-1 reservoir consists of latently infected cells that persist despite antiretroviral therapy (ART). Elucidating the proviral genetic composition of the reservoir, particularly in the context of pre-therapy viral diversity, is therefore important to understanding reservoir formation and the persistence of latently infected cells. Here we investigate reservoir proviral variants from 13 Zambian acutely-infected individuals with additional pre-therapy sampling for a unique comparison to the ART-naïve quasispecies. Read More

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http://dx.doi.org/10.1371/journal.ppat.1008378DOI Listing

Examining the impact of the Respect in Sport Parent Program on the psychosocial experiences of minor hockey athletes.

J Sports Sci 2020 Jun 3:1-11. Epub 2020 Jun 3.

Faculty of Kinesiology and Physical Education, University of Toronto , Toronto, Canada.

Models of positive youth development suggest that athletes may be influenced by parent education programmes; however, there is little research examining the impact of such programmes on athlete outcomes. This study examined the impact of the Respect in Sport Parent Program on athlete outcomes among minor hockey players over three years. This study consisted of cross-sectional and longitudinal online surveys measuring athletes' positive and negative developmental experiences, prosocial and antisocial behaviours, parental support and pressure, and sport enjoyment and commitment. Read More

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http://dx.doi.org/10.1080/02640414.2020.1767839DOI Listing

Documenting change with the Canadian Occupational Performance Measure for children with cerebral palsy.

Dev Med Child Neurol 2020 Jun 3. Epub 2020 Jun 3.

Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.

Aim: To assess the Canadian Occupational Performance Measure's (COPM) ability to document change over 3 years in children with cerebral palsy (CP).

Method: This was a prospective study with ambulatory children with CP, aged 2 to 6 years. Caregivers set one to three COPM goals which were rescored annually over 3 years. Read More

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http://dx.doi.org/10.1111/dmcn.14569DOI Listing

Mitochondrial ion channels as targets for cardioprotection.

J Cell Mol Med 2020 Jun 3. Epub 2020 Jun 3.

Department of Biomedical Sciences, University of Padova, Padova, Italy.

Acute myocardial infarction (AMI) and the heart failure (HF) that often result remain the leading causes of death and disability worldwide. As such, new therapeutic targets need to be discovered to protect the myocardium against acute ischaemia/reperfusion (I/R) injury in order to reduce myocardial infarct (MI) size, preserve left ventricular function and prevent the onset of HF. Mitochondrial dysfunction during acute I/R injury is a critical determinant of cell death following AMI, and therefore, ion channels in the inner mitochondrial membrane, which are known to influence cell death and survival, provide potential therapeutic targets for cardioprotection. Read More

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http://dx.doi.org/10.1111/jcmm.15341DOI Listing

Ammonia Thermal Treatment toward Topological Defects in Porous Carbon for Enhanced Carbon Dioxide Electroreduction.

Adv Mater 2020 Jun 3:e2001300. Epub 2020 Jun 3.

Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, P. R. China.

Topological defects, with an asymmetric local electronic redistribution, are expected to locally tune the intrinsic catalytic activity of carbon materials. However, it is still challenging to deliberately create high-density homogeneous topological defects in carbon networks due to the high formation energy. Toward this end, an efficient NH thermal-treatment strategy is presented for thoroughly removing pyrrolic-N and pyridinic-N dopants from N-enriched porous carbon particles, to create high-density topological defects. Read More

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http://dx.doi.org/10.1002/adma.202001300DOI Listing

Evaluation of a Novel Protocol for Assessment and Treatment of Alcohol Withdrawal Syndrome in Psychiatric Inpatients.

Am J Addict 2020 Jun 3. Epub 2020 Jun 3.

Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.

Background And Objectives: Despite the high incidence of alcohol withdrawal syndrome (AWS) in psychiatric inpatients, standardized methods for assessing and treating AWS have been studied only once before in this population. We evaluated a novel AWS assessment and treatment protocol designed for psychiatric inpatients.

Methods: This retrospective cohort study evaluated outcomes before and after implementation of the protocol. Read More

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http://dx.doi.org/10.1111/ajad.13058DOI Listing

The evolution of virtual reality in shoulder and elbow surgery.

JSES Int 2020 Jun 7;4(2):215-223. Epub 2020 May 7.

Department of Orthopaedics, University of British Columbia, Vancouver, BC, Canada.

Virtual Reality (VR) in orthopedic surgery has significantly increased in popularity in the areas of preoperative planning, intraoperative usage, and for education and training; however, its utilization lags behind other surgical disciplines and industries. The use of VR in orthopedics is largely focused on education and is currently endorsed by North American and European training committees. The use of VR in shoulder and elbow surgery has varying levels of evidence, from I to IV, and typically involves educational randomized controlled trials. Read More

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http://dx.doi.org/10.1016/j.jseint.2020.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256885PMC

How the World's Children Hear: A Narrative Review of School Hearing Screening Programs Globally.

OTO Open 2020 Apr-Jun;4(2):2473974X20923580. Epub 2020 May 19.

Department of Head and Neck Surgery and Communication Sciences, School of Medicine, Duke University, Durham, North Carolina, USA.

Objective: School hearing screening may mitigate the effects of childhood hearing loss through early identification and intervention. This study provides an overview of existing school hearing screening programs around the world, identifies gaps in the literature, and develops priorities for future research.

Data Sources: A structured search of the PubMed, Embase, and Cochrane Library databases. Read More

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http://dx.doi.org/10.1177/2473974X20923580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238315PMC

Impact of an Open Access Nationwide Treatment Model on Hepatitis C Virus Antiviral Drug Resistance.

Hepatol Commun 2020 Jun 6;4(6):904-915. Epub 2020 Apr 6.

Storr Liver Centre The Westmead Institute for Medical Research The University of Sydney and Westmead Hospital Sydney Australia.

Direct acting antivirals (DAAs) have revolutionized hepatitis C virus (HCV) treatment, but drug resistance could undermine proposed global elimination targets. Real-world studies are needed to inform the impact of widespread DAA treatment on antiviral resistance in the community. The prevalence and range of posttreatment resistance-associated substitutions (RASs) was determined in Australian patients with open access to DAAs through a wide range of prescribers. Read More

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http://dx.doi.org/10.1002/hep4.1496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262285PMC

An Epoxide Intermediate in Glycosidase Catalysis.

ACS Cent Sci 2020 May 16;6(5):760-770. Epub 2020 Apr 16.

School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria 3010, Australia.

Retaining glycoside hydrolases cleave their substrates through stereochemical retention at the anomeric position. Typically, this involves two-step mechanisms using either an enzymatic nucleophile via a covalent glycosyl enzyme intermediate or neighboring-group participation by a substrate-borne 2-acetamido neighboring group via an oxazoline intermediate; no enzymatic mechanism with participation of the sugar 2-hydroxyl has been reported. Here, we detail structural, computational, and kinetic evidence for neighboring-group participation by a mannose 2-hydroxyl in glycoside hydrolase family 99 -α-1,2-mannanases. Read More

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http://dx.doi.org/10.1021/acscentsci.0c00111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256955PMC

A Shut-and-Open Case: An Epoxide Intermediate Spotted in the Reaction Coordinate of a Family of Glycoside Hydrolases.

Authors:
David J Vocadlo

ACS Cent Sci 2020 May 6;6(5):619-621. Epub 2020 May 6.

Department of Chemistry and Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada.

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http://dx.doi.org/10.1021/acscentsci.0c00482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256941PMC

High Burden of Cardiac Disease in Pregnancy at a National Referral Hospital in Western Kenya.

Glob Heart 2020 Feb 7;15(1):10. Epub 2020 Feb 7.

Directorate of Reproductive Health, Moi Teaching and Referral Hospital, Eldoret, KE.

Background: Cardiac disease is a leading cause of non-obstetric maternal death worldwide, but little is known about its burden in sub-Saharan Africa.

Objectives And Methods: We conducted a retrospective case-control study of pregnant women admitted to a national referral hospital in western Kenya between 2011-2016. Its purpose was to define the burden and spectrum of cardiac disease in pregnancy and assess the utility of the CARPREG I and modified WHO (mWHO) clinical risk prediction tools in this population. Read More

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http://dx.doi.org/10.5334/gh.404DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218778PMC
February 2020

Post-exertional increase in first-phase ejection fraction in recreational marathon runners.

JRSM Cardiovasc Dis 2020 Jan-Dec;9:2048004020926366. Epub 2020 May 18.

Department of Clinical Pharmacology, King's College London, British Heart Foundation Centre, London, UK.

Objectives: Running a marathon has been equivocally associated with acute changes in cardiac performance. First-phase ejection fraction is a novel integrated echocardiographic measure of left ventricular contractility and systo-diastolic coupling which has never been studied in the context of physical activity. The aim of this study was to assess first-phase ejection fraction following recreational marathon running along with standard echocardiographic indices of systolic and diastolic function. Read More

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http://dx.doi.org/10.1177/2048004020926366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238440PMC

Nice guideline on thyroid disease: where does it take us with liothyronine?

Authors:
Graham P Leese

Thyroid Res 2020 23;13. Epub 2020 May 23.

Ward 5 Ninewells Hospital, Dundee, DD1 9SY UK.

The new NICE guidelines on thyroid disease and its management do not recommend the routine use of liothyronine, but do not completely rule it out either. Guidelines from the British and European Thyroid Associations are open to a "trial of liothyronine" on an individual basis. Some patients do not feel well on L-thyroxine despite a serum TSH in the reference range. Read More

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http://dx.doi.org/10.1186/s13044-020-00081-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245024PMC

Impact of Recurrence Score on type and duration of chemotherapy in breast cancer.

Curr Oncol 2020 Apr 1;27(2):e86-e92. Epub 2020 May 1.

Medical Oncology, BC.

Background: The use of Oncotype dx (Genomic Health, Redwood City, CA, U.S.A. Read More

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http://dx.doi.org/10.3747/co.27.5635DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253753PMC

A catalyst for transforming health systems and person-centred care: Canadian national position statement on patient-reported outcomes.

Curr Oncol 2020 Apr 1;27(2):90-99. Epub 2020 May 1.

Alberta: Department of Oncology, University of Calgary, Calgary (Barbera, Bebb, Cheung); University of Calgary, Calgary (Crump, Temple); Departments of Surgery and Oncology, University of Calgary, Calgary (McKinnon); Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary (Pink, Santana); University of Calgary and Tom Baker Cancer Centre, Calgary (Robinson); Faculty of Nursing, University of Calgary, Calgary (Sinclair).

Background: Patient-reported outcomes (pros) are essential to capture the patient's perspective and to influence care. Although pros and pro measures are known to have many important benefits, they are not consistently being used and there is there no Canadian pros oversight. The Position Statement presented here is the first step toward supporting the implementation of pros in the Canadian health care setting. Read More

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http://dx.doi.org/10.3747/co.27.6399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253746PMC

Treatment of non-small-cell lung cancer after progression on nivolumab or pembrolizumab.

Curr Oncol 2020 Apr 1;27(2):76-82. Epub 2020 May 1.

BC Cancer-Victoria, Victoria, BC.

Background: Although PD-1 antibodies (PD1 Ab) are the standard of care for advanced non-small-cell lung cancer (ansclc), most patients will progress. We compared survival outcomes for patients with ansclc who received systemic therapy (st) after progression and for those who did not. Additionally, clinical characteristics that predicted receipt of st after PD1 Ab failure were evaluated. Read More

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http://dx.doi.org/10.3747/co.27.5495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253749PMC

Impact of COVID-19 on Canadian medical oncologists and cancer care: Canadian Association of Medical Oncologists survey report.

Curr Oncol 2020 Apr 1;27(2):71-74. Epub 2020 May 1.

Dalhousie University, Halifax, NS.

Background: The covid-19 pandemic has presented unprecedented professional and personal challenges for the oncology community. Under the auspices of the Canadian Association of Medical Oncologists, we conducted an online national survey to better understand the impact of the pandemic on the medical oncology community in Canada.

Methods: An English-language multiple-choice survey, including questions about demographics, covid-19 risk, use of personal protective equipment (ppe), personal challenges, and chemotherapy management was distributed to Canadian medical oncologists. Read More

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http://dx.doi.org/10.3747/co.27.6643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253737PMC

Bridging Barriers to Cervical Cancer Screening in Transgender Men: A Scoping Review.

Am J Mens Health 2020 May-Jun;14(3):1557988320925691

School of Nursing, University of British Columbia, Vancouver, BC, Canada.

Estimates of high-risk human papillomavirus (HPV) infection and susceptibility to HPV-related cancer in transgender men (TM) are comparable to prevalence rates found in cisgender women. Regular and thorough screening for cervical cancer is equally as crucial for TM as for cisgender women; however, despite continued risk for cervical cancer in TM and associated recommendations for screening, studies indicate disparities in rates of cervical cancer screening (CCS) in TM compared to cisgender women. The current scoping review explores TM's knowledge and experiences of CCS and barriers to screening uptake in this population. Read More

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http://dx.doi.org/10.1177/1557988320925691DOI Listing

Surgical cancellation rates due to peri-operative hypertension: implementation of multidisciplinary guidelines across primary and secondary care.

Anaesthesia 2020 Jun 2. Epub 2020 Jun 2.

Imperial College Healthcare NHS Trust, London, UK.

Patients with uncontrolled hypertension are at increased risk of complications during general anaesthesia but the number of patients whose surgery is delayed or cancelled due to hypertension remains unknown. Prospective, regional multicentre service evaluations were performed on consecutive patients undergoing elective surgery before and after the publication of new guidelines from the Association of Anaesthetists and the British Hypertensive Society. The aim was to quantify the number of operations cancelled due to hypertension alone and to assess impact of the guidelines on cancellation rates. Read More

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http://dx.doi.org/10.1111/anae.15084DOI Listing

Free Radical Chemistry of Phosphasilenes.

Angew Chem Int Ed Engl 2020 Jun 2. Epub 2020 Jun 2.

Simon Fraser University, Chemistry, 8888 University Drive, V5A 1S6, Burnaby, CANADA.

Understanding the characteristics of radicals formed from silicon-containing heavy analogues of alkenes is of great importance for their application in radical polymerization. Bulky and electronic substituent effects in such compounds as phosphasilenes not only stabilize the Si=P double bond, but also influence the structure and species of the formed radicals. Herein we report our first investigations of radicals derived from phosphasilenes with Mes (2,4,6-trimethylphenyl), Tip (2,4,6-triisopropylphenyl), Dur (2,3,5,6-tetramethylphenyl) and NMe 2 (dimethylamino) substituents on the P atom, using muon spin spectroscopy and DFT calculations. Read More

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http://dx.doi.org/10.1002/anie.202006289DOI Listing

COVID-19 and sex workers: human rights, the struggle for safety and minimum income.

Can J Public Health 2020 Jun 2. Epub 2020 Jun 2.

Sex Workers United Against Violence Society, 334 Alexander St, Vancouver, BC, V6A 1C3, Canada.

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http://dx.doi.org/10.17269/s41997-020-00350-1DOI Listing

Trehalose Inhibits Aβ Generation and Plaque Formation in Alzheimer's Disease.

Mol Neurobiol 2020 Jun 2. Epub 2020 Jun 2.

Chongqing City Key Lab of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.

Alzheimer's disease (AD) is the most common neurodegenerative disease, and there has been no disease-modifying treatment for AD. Recent studies suggest that trehalose may have beneficial effect on neurodegenerative diseases through regulating autophagy and facilitating aggregated protein clearance. However, the effects of trehalose on AD-related neuropathologies are still unknown. Read More

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http://dx.doi.org/10.1007/s12035-020-01942-1DOI Listing

#ItsNotInYourHead: A Social Media Campaign to Disseminate Information on Provoked Vestibulodynia.

Arch Sex Behav 2020 Jun 2. Epub 2020 Jun 2.

Women's Health Research Institute, Vancouver, BC, Canada.

Provoked Vestibulodynia (PVD) is a type of localized vulvodynia (or pain in the vulva). The estimated prevalence of this condition is about 12% of the general population and approximately 20% of women under the age of 19. Many women who live with PVD suffer in silence for years before receiving a diagnosis. Read More

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http://dx.doi.org/10.1007/s10508-020-01731-wDOI Listing

Coronavirus surveillance of wildlife in the Lao People's Democratic Republic detects viral RNA in rodents.

Arch Virol 2020 Jun 1. Epub 2020 Jun 1.

Metabiota Inc., Nanaimo, BC, Canada.

Coronaviruses can become zoonotic, as in the case of COVID-19, and hunting, sale, and consumption of wild animals in Southeast Asia increases the risk for such incidents. We sampled and tested rodents (851) and other mammals and found betacoronavirus RNA in 12 rodents. The sequences belong to two separate genetic clusters and are closely related to those of known rodent coronaviruses detected in the region and distantly related to those of human coronaviruses OC43 and HKU1. Read More

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http://dx.doi.org/10.1007/s00705-020-04683-7DOI Listing

When Home is Not a Safe Place: Impacts of Social Distancing Directives on Women Living with HIV.

AIDS Behav 2020 Jun 2. Epub 2020 Jun 2.

Faculty of Health Sciences, Burnaby, Canada, Simon Fraser University, Blusson Hall, 8888 University Drive, Burnaby, B.C, V5A 1S6, Canada.

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http://dx.doi.org/10.1007/s10461-020-02941-yDOI Listing

Effect of canal curvature location on the cyclic fatigue resistance of reciprocating files.

Clin Oral Investig 2020 Jun 2. Epub 2020 Jun 2.

Division of Endodontics, Faculty of Dentistry, The University of British Columbia (UBC), 2199 Wesbrook Mall, Vancouver, V6T1Z3, Canada.

Objectives: To determine the effect of the location of the canal curvature on the fatigue resistance of WaveOne (WO), WaveOne Gold (WOG), Reciproc (Rec), and Reciproc Blue (RecB) files, and to examine the phase transformation behaviors of the reciprocating file systems.

Material And Methods: The instruments were subjected to fatigue testing in five artificial canals with a curvature of 60° angle and a 3-mm radius. The location of the curvature was unique for each canal. Read More

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http://dx.doi.org/10.1007/s00784-020-03348-8DOI Listing

A Facile and Novel Approach to Manufacture Paclitaxel-Loaded Proliposome Tablet Formulations of Micro or Nano Vesicles for Nebulization.

Pharm Res 2020 Jun 2;37(6):116. Epub 2020 Jun 2.

School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston, PR1 2HE, UK.

Purpose: The aim of this study was to develop novel paclitaxel-loaded proliposome tablet formulations for pulmonary drug delivery.

Method: Proliposome powder formulations (i.e. Read More

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http://dx.doi.org/10.1007/s11095-020-02840-wDOI Listing

The Human Leukocyte Antigen Locus and Rheumatic Heart Disease Susceptibility in South Asians and Europeans.

Sci Rep 2020 Jun 2;10(1):9004. Epub 2020 Jun 2.

The Wellcome Centre for Human Genetics, University of Oxford, Oxford, Oxfordshire, OX3 7BN, UK.

Rheumatic heart disease (RHD), an autoinflammatory heart disease, was recently declared a global health priority by the World Health Organization. Here we report a genome-wide association study (GWAS) of RHD susceptibility in 1,163 South Asians (672 cases; 491 controls) recruited in India and Fiji. We analysed directly obtained and imputed genotypes, and followed-up associated loci in 1,459 Europeans (150 cases; 1,309 controls) from the UK Biobank study. Read More

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http://dx.doi.org/10.1038/s41598-020-65855-8DOI Listing

Evaluating the ASTHMAXcel Mobile Application Regarding Asthma Knowledge and Clinical Outcomes.

Respir Care 2020 Jun 2. Epub 2020 Jun 2.

Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York.

Background: We sought to longitudinally assess the efficacy of the patient-facing ASTHMAXcel mobile application in improving asthma knowledge and outcomes in adults with asthma.

Methods: ASTHMAXcel is a novel smartphone application consistent with the National Asthma Education and Prevention Program, Global Initiative for Asthma, and British Thoracic Society/Scottish Intercollegiate Guidelines Network guidelines. The intervention was provided for 1-time use at baseline only. Read More

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http://dx.doi.org/10.4187/respcare.07550DOI Listing

Master Sculptor at Work: Enteropathogenic Escherichia coli Infection Uniquely Modifies Mitochondrial Proteolysis during Its Control of Human Cell Death.

mSystems 2020 Jun 2;5(3). Epub 2020 Jun 2.

Department of Microbiology & Immunology, University of British Columbia, Vancouver, Canada

Enteropathogenic (EPEC) causes severe diarrheal disease and is present globally. EPEC virulence requires a bacterial type III secretion system to inject >20 effector proteins into human intestinal cells. Three effectors travel to mitochondria and modulate apoptosis; however, the mechanisms by which effectors control apoptosis from within mitochondria are unknown. Read More

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http://dx.doi.org/10.1128/mSystems.00283-20DOI Listing

ABN News.

Pract Neurol 2020 May;20(3):270

Department of Neurology, Manchester Centre for Clinical Neuroscience, Greater Manchester, UK

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http://dx.doi.org/10.1136/practneurol-2020-002608DOI Listing

Reflecting on success in trauma research: experiences from the SGCNS and SIR studies.

BMJ Mil Health 2020 Jun 2. Epub 2020 Jun 2.

Applied Physiology Department, Institute of Naval Medicine, Gosport, Hampshire, UK.

The inclusion of British Service Personnel (SP) lacking capacity into research studies from the point of injury through to medium-term rehabilitation had not previously been undertaken until work to support operations in Afghanistan (2001-2014). The Surgeon General's Casualty Nutrition Study and the Steroids and Immunity from Injury through to Rehabilitation Study sought to address the nutrition, endocrine and immune responses in a military patient cohort. A fundamental part of research is to feedback to patients, their relatives and ward staff on data collection and outcomes, and how future research may be improved to better support both injured SP and trauma patients in the UK. Read More

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http://dx.doi.org/10.1136/bmjmilitary-2020-001467DOI Listing

Distance travelled by military recruits during basic training is a significant risk factor for lower limb overuse injury.

BMJ Mil Health 2020 Jun 2. Epub 2020 Jun 2.

Department of Aerospace Engineering, Texas A&M University, College Station, Texas, USA

Introduction: Military initial training results in a high incidence of lower limb overuse injuries (stress fractures and medial tibial stress syndrome). This study aimed to determine whether the distance travelled by recruits, both on and off duty, was a risk factor for overuse injury.

Methods: 14 male airborne infantry recruits from three training platoons carried global positioning system receivers throughout the first 19 weeks of basic military training. Read More

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http://dx.doi.org/10.1136/bmjmilitary-2020-001445DOI Listing

Ionoregulatory aspects of the hypoxia-induced osmorespiratory compromise in the euryhaline Atlantic killifish (): the effects of salinity.

J Exp Biol 2020 Jun 2. Epub 2020 Jun 2.

Department of Zoology, The University of British Columbia, Vancouver, BC, V6T 1Z4, Canada.

The osmorespiratory compromise is a physiological trade-off between the characteristics of the gill that promote respiratory gas-exchange and those that limit passive fluxes of ions and water with the environment. In hypoxia, changes in gill blood flow patterns and functional surface area that increase gas transfer can promote an exacerbation in ion and water fluxes. Our goal was to determine whether the osmorespiratory compromise is flexible, depending on environmental salinity (fresh, isosmotic and sea water) and oxygen levels (hypoxia) in euryhaline killifish, Plasma ion concentrations were minimally affected by hypoxia, indicating a maintenance of osmoregulatory homeostasis. Read More

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http://dx.doi.org/10.1242/jeb.216309DOI Listing

Medial temporal lobe cortical changes in response to exercise interventions in people with early psychosis: A randomized controlled trial.

Schizophr Res 2020 May 30. Epub 2020 May 30.

Department of Radiology, University of British Columbia, Canada. Electronic address:

Objective: Individuals with early psychosis may have prefrontal-limbic cortical deficits, which are associated with symptom severity and cognitive impairment. This study investigated the impact of an exercise intervention on fronto-temporal cortical plasticity in female participants with early psychosis.

Methods: In a cohort of 51 female participants with early psychosis from Hong Kong, we investigated the effects of a 12-week, moderate intensity aerobic or Hatha yoga exercise trial (yoga (N = 21), aerobic (N = 18) or waitlist group (N = 12)) on cortical grey matter. Read More

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http://dx.doi.org/10.1016/j.schres.2020.05.043DOI Listing

Microstructural examination and corrosion behavior of selective laser melted and conventionally manufactured Ti6Al4V for dental applications.

Mater Sci Eng C Mater Biol Appl 2020 Aug 19;113:110980. Epub 2020 Apr 19.

School of Engineering and Technology, Central Michigan University, Mount Pleasant, MI, United States. Electronic address:

The selective laser melting of Ti6Al4V would induce definite changes in the microstructure that may affect its corrosion properties. Microstructural examination showed the formation of relatively thin beta (β) lamella in selective laser melted (SLM) Ti6Al4V compared to wrought Ti6Al4V. X-ray diffraction analysis (XRD) analysis confirmed the presence of alpha and beta phases in both SLM and wrought Ti6Al4V. Read More

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http://dx.doi.org/10.1016/j.msec.2020.110980DOI Listing

A relational ethic of rural home support on two Gulf Island communities, 1978-2018.

J Aging Stud 2020 Jun 7;53:100847. Epub 2020 May 7.

Health & Society Program, Department of Social Science, York University, 704A Ross Building South, 4700 Keele St., Toronto, ON M3J 1P3, Canada. Electronic address:

Since their widespread establishment in the 1970s, home support services across Canada have been subject to shifting state logics, policies, and funding models. The impacts and responses of local actors differ across historical, socio-cultural, and geographical settings. This paper traces the development and evolution of a small home support society on two rural islands off the coast of British Columbia, Canada. Read More

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http://dx.doi.org/10.1016/j.jaging.2020.100847DOI Listing

Performing in a different place: the use of a prodigy to the Dublin Philosophical Society.

Authors:
Paddy Holt

Br J Hist Sci 2020 Jun 3:1-18. Epub 2020 Jun 3.

School of History and Philosophy of Science, the University of Sydney, Carslaw Building F07, Darlington, NSW2006, Australia. Email:

From 8 February until at least 19 April 1686, the Dublin Philosophical Society was occupied with a prodigiously talented young girl whose name was never recorded. She was less than eleven years of age, but still much older than the society itself, which had begun meeting less than three years previously. Although one of many wonders engaging the curiosity of the nascent society, this girl served a surprising range of purposes, so that accompanying her anonymity was a curious malleability. Read More

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http://dx.doi.org/10.1017/S0007087420000205DOI Listing

Care transition from hospital to home: cancer patients' perspective.

BMC Res Notes 2020 Jun 1;13(1):267. Epub 2020 Jun 1.

Regional University of the Northwest of the State of Rio Grande do Sul, Ijuí, RS, Brazil.

Objectives: The present database contains information on sociodemographic and clinical data as well as data from the Care Transition Measure (CTM 15-Brazil) of cancer patients undergoing clinical or surgical treatment. Data collection was carried out 7 to 30 days after patients' hospital discharge from June to August 2019. Understanding these data can contribute to improving quality of care transitions and avoiding hospital readmissions. Read More

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http://dx.doi.org/10.1186/s13104-020-05099-xDOI Listing

Short-term effects of Lumacaftor/Ivacaftor (Orkambi™) on exertional symptoms, exercise performance, and ventilatory responses in adults with cystic fibrosis.

Respir Res 2020 Jun 1;21(1):135. Epub 2020 Jun 1.

Clinician-Scientist, UBC Centre for Heart Lung Innovation, Providence Health Care Research Institute, University of British Columbia, St. Paul's Hospital, #166 - 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada.

Rationale: Lumacaftor/ivacaftor (LUM/IVA) modestly improves lung function following 1 month of treatment but it is unknown if this translates into improvements in exercise endurance and exertional symptoms.

Methods: Adult CF participants completed a symptom-limited constant load cycling test with simultaneous assessments of dyspnea and leg discomfort ratings pre- and 1 month post-initiation of LUM/IVA.

Results: Endurance time, exertional dyspnea and leg discomfort ratings at submaximal exercise did not change significantly. Read More

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http://dx.doi.org/10.1186/s12931-020-01406-zDOI Listing

PET/CT of breast cancer regional nodal recurrences: an evaluation of contouring atlases.

Radiat Oncol 2020 Jun 1;15(1):136. Epub 2020 Jun 1.

Department of Radiation Oncology, BC Cancer, Vancouver Centre, Vancouver, British Columbia, Canada.

Background: To validate the Radiation Therapy Oncology Group (RTOG) and European Society for Radiotherapy and Oncology (ESTRO) breast cancer nodal clinical target volumes (CTVs) and to investigate the Radiotherapy Comparative Effectiveness Consortium (RADCOMP) Posterior Neck volume in relation to regional nodal recurrences (RNR).

Methods: From a population-based database, 69 patients were identified who developed RNR after curative treatment for breast cancer. RNRs were detected with 18-fluorodeoxyglucose-positron emission tomography-computed tomography (PET/CT). Read More

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http://dx.doi.org/10.1186/s13014-020-01576-6DOI Listing