147,912 results match your criteria British journal of psychology London England : 1953[Journal]


A Facial-Action Imposter: How Head Tilt Influences Perceptions of Dominance From a Neutral Face.

Psychol Sci 2019 Apr 22:956797619838762. Epub 2019 Apr 22.

Department of Psychology, The University of British Columbia.

Research on face perception tends to focus on facial morphology and the activation of facial muscles while ignoring any impact of head position. We raise questions about this approach by demonstrating that head movements can dramatically shift the appearance of the face to shape social judgments without engaging facial musculature. In five studies (total N = 1,517), we found that when eye gaze was directed forward, tilting one's head downward (compared with a neutral angle) increased perceptions of dominance, and this effect was due to the illusory appearance of lowered and V-shaped eyebrows caused by a downward head tilt. Read More

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http://dx.doi.org/10.1177/0956797619838762DOI Listing

Art-making to deepen our understanding of illness.

Authors:
Vivian Gu

CMAJ 2019 Feb;191(8):E233-E234

University of British Columbia, Vancouver, BC.

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http://dx.doi.org/10.1503/cmaj.181050DOI Listing
February 2019

Effects of Dexmedetomidine on Blood Glucose and Serum Potassium Levels in Children Undergoing General Anesthesia: A Secondary Analysis of Safety Endpoints During a Randomized Controlled Trial.

Anesth Analg 2019 Apr 16. Epub 2019 Apr 16.

From the Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada.

Background: Dexmedetomidine is a highly selective α2-adrenergic agonist, which is increasingly used in pediatric anesthesia and intensive care. Potential adverse effects that have not been rigorously evaluated in children include its effects on blood glucose and serum potassium concentrations, which are relevant due to the associations of derangements of both parameters with undesired outcomes. We investigated the effects of 3 different doses of dexmedetomidine on these outcomes in a randomized controlled trial in children undergoing elective surgery. Read More

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http://dx.doi.org/10.1213/ANE.0000000000004154DOI Listing
April 2019
1 Read

Retention following Two-Stage Collaborative Exams Depends on Timing and Student Performance.

CBE Life Sci Educ 2019 Jun;18(2):ar12

Carl Wieman Science Education Initiative, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.

Multistage collaborative exams are implemented to enhance learning and retention of course material. However, the effects of multistage collaborative exams on retention of course content are varied. These discrepancies may be due to a number of factors. Read More

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http://dx.doi.org/10.1187/cbe.17-07-0137DOI Listing

Everyday associations between older adults' physical activity, negative affect, and cortisol.

Health Psychol 2019 Apr 22. Epub 2019 Apr 22.

Department of Psychology, The University of British Columbia.

Objective: Experimental research has demonstrated that individuals with higher physical activity levels show reduced cortisol responses to psychosocial stress. The present study takes this research out of the lab and it extends these findings by investigating whether older adults' physical activity also moderates everyday-life within-person associations between momentary negative affect and concurrent salivary cortisol.

Methods: A sample of 162 older adults aged 60 to 87 years (M age = 71 years; 50% women; 57% Caucasian) completed affect assessments and provided concurrent salivary cortisol samples 4 times per day over 7 consecutive days. Read More

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http://dx.doi.org/10.1037/hea0000743DOI Listing

Identification of novel Adenosine Deaminase 2 gene variants and varied clinical phenotype in pediatric vasculitis.

Arthritis Rheumatol 2019 Apr 22. Epub 2019 Apr 22.

BC Children's Hospital Research Institute, BC Children's Hospital, Vancouver, BC, Canada.

Objectives: Individuals with deficiency of adenosine deaminase 2 (DADA2), a recently recognized autosomal recessive disease, present with various systemic vascular and inflammatory manifestations, often with early-onset age, or recurrent strokes. Their clinical features and histological findings overlap with those of childhood onset polyarteritis nodosa (PAN), a primary "idiopathic" systemic vasculitis. Despite similar clinical presentation, individuals with DADA2 may respond better to biologic therapy than traditional immunosuppression. Read More

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http://dx.doi.org/10.1002/art.40913DOI Listing

Moderate emotional reactions to stressful life events are associated with lowest risk of increased alcohol consumption: evidence from the Whitehall II study.

Eur J Public Health 2019 Apr 22. Epub 2019 Apr 22.

Department of Psychology, Claremont McKenna College, Claremont, CA, USA.

Background: Research investigating the associations between stress-related negative emotions and alcohol consumption often assumes a linear dose-response relationship. Based on the current theories of emotions, we questioned this assumption and hypothesized that both very low and very high levels of negative emotional response (NER) to stressful life events are related to increased alcohol consumption.

Methods: We used data from Phases 1 (1985-88) and 2 (1989-90) of the British Whitehall II study. Read More

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http://dx.doi.org/10.1093/eurpub/ckz066DOI Listing

Window to the Unknown: Using Storytelling to Identify Learning Needs for the Intrinsic Competencies Within an Online Needs Assessment.

AEM Educ Train 2019 Apr 6;3(2):179-187. Epub 2019 Jan 6.

Division of Emergency Medicine Department of Medicine McMaster University Hamilton ON.

Introduction: Needs assessments are important for developing online educational resources, but they frequently do not capture learning needs in the intrinsic physician competencies. Storytelling exercises, by promoting critical reflection and emphasizing values and context, may assist curriculum developers in identifying emergent knowledge gaps in these areas that are initially unknown to learners.

Methods: We developed an online curriculum for thrombosis and hemostasis based on an open-access online needs assessment comprised of a topic list, case scenarios, and storytelling exercise. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/aet2.10315
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http://dx.doi.org/10.1002/aet2.10315DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457385PMC

Coaching for Chaos: A Qualitative Study of Instructional Methods for Multipatient Management in the Emergency Department.

AEM Educ Train 2019 Apr 28;3(2):145-155. Epub 2018 Dec 28.

Simulation Research, Assessment, and Outcomes, Zamierowski Institute for Experiential Learning, and Department of Health Policy and Management University of Kansas Medical Center Kansas City KS.

Background: Busy environments, like the emergency department (ED), require teachers to develop instructional strategies for coaching trainees to function within these same environments. Few studies have documented the strategies used by emergency physician (EP)-teachers within these busy, chaotic environments, instead emphasizing teaching in more predictable environments such as the outpatient clinic, hospital wards, or operating room. The authors sought to discover what strategies EP-teachers were using and what trainees recalled experiencing when learning to handle these unpredictable, overcrowded, complex, multipatient environments. Read More

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http://dx.doi.org/10.1002/aet2.10312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457384PMC

Physical Conditions of Fast Glacier Flow: 3. Seasonally-Evolving Ice Deformation on Store Glacier, West Greenland.

J Geophys Res Earth Surf 2019 Jan 30;124(1):245-267. Epub 2019 Jan 30.

Scott Polar Research Institute University of Cambridge Cambridge UK.

Temporal variations in ice sheet flow directly impact the internal structure within ice sheets through englacial deformation. Large-scale changes in the vertical stratigraphy within ice sheets have been previously conducted on centennial to millennial timescales; however, intra-annual changes in the morphology of internal layers have yet to be explored. Over a period of 2 years, we use autonomous phase-sensitive radio-echo sounding to track the daily displacement of internal layers on Store Glacier, West Greenland, to millimeter accuracy. Read More

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http://dx.doi.org/10.1029/2018JF004821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472443PMC
January 2019

Anatomy of the Ediacaran rangeomorph .

Pap Palaeontol 2019 Feb 11;5(1):157-176. Epub 2018 Sep 11.

Department of Earth Sciences University of Cambridge Downing Street Cambridge CB2 3EQ UK.

The Ediacaran macrofossil Ford is perhaps the most iconic member of the Rangeomorpha: a group of seemingly sessile, frondose organisms that dominates late Ediacaran benthic, deep-marine fossil assemblages. Despite exhibiting broad palaeogeographical and stratigraphical ranges, there have been few morphological studies that consider the variation observed among populations of specimens derived from multiple global localities. We present an analysis of that evaluates specimens from the UK, Canada and Russia, representing the largest morphological study of this taxon to date. Read More

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http://dx.doi.org/10.1002/spp2.1234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472560PMC
February 2019

Correction to: Eosinophilic esophagitis.

Allergy Asthma Clin Immunol 2019 10;15:22. Epub 2019 Apr 10.

4Division of Allergy, Department of Pediatrics, IWK Health Centre, Dalhousie University, Halifax, NS Canada.

[This corrects the article DOI: 10.1186/s13223-018-0287-0.]. Read More

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http://dx.doi.org/10.1186/s13223-019-0336-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456987PMC

Traditional plant functional groups explain variation in economic but not size-related traits across the tundra biome.

Glob Ecol Biogeogr 2019 Jan 16;28(2):78-95. Epub 2018 Nov 16.

Environmental Biology, Department Institute of Environmental Sciences, CML, Leiden University Leiden The Netherlands.

Aim: Plant functional groups are widely used in community ecology and earth system modelling to describe trait variation within and across plant communities. However, this approach rests on the assumption that functional groups explain a large proportion of trait variation among species. We test whether four commonly used plant functional groups represent variation in six ecologically important plant traits. Read More

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http://dx.doi.org/10.1111/geb.12783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472633PMC
January 2019

Cr isotopic insights into ca. 1.9 Ga oxidative weathering of the continents using the Beaverlodge Lake paleosol, Northwest Territories, Canada.

Geobiology 2019 Apr 21. Epub 2019 Apr 21.

British Columbia Geological Survey, Stn Prov Govt, Victoria, BC, Canada.

The ca. 1.9 Ga Beaverlodge Lake paleosol was studied using redox-sensitive Cr isotopes in order to determine the isotopic response to paleoweathering of a rhyodacite parent rock 500 million years after the Great Oxidation Event. Read More

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http://dx.doi.org/10.1111/gbi.12342DOI Listing

Psychological wellbeing and use of alcohol and recreational drugs: results of the British HIV Association (BHIVA) national audit 2017.

HIV Med 2019 Apr 22. Epub 2019 Apr 22.

The James Cook University Hospital, Middlesbrough, UK.

Objectives: The aim of this national audit was to assess adherence of services providing HIV care in the UK to national standards and guidelines regarding psychological support and the assessment of alcohol and recreational drug use (including chemsex drugs) in people living with HIV (PLWH).

Methods: Participating sites completed a survey of their services' care pathways relating to psychological support and substance use. They performed a case-note review of up to 40 adult PLWH per service, reviewing sociodemographic and clinical information and assessment of psychological wellbeing, drug use and alcohol use. Read More

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http://dx.doi.org/10.1111/hiv.12744DOI Listing

CrossTalk proposal: Heart rate variability is a valid measure of cardiac autonomic responsiveness.

J Physiol 2019 Apr 21. Epub 2019 Apr 21.

Department of Cardiology and Pneumology, Heart Center - University of Göttingen Medical Center, Göttingen, Germany.

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http://dx.doi.org/10.1113/JP277500DOI Listing

Melanonychia striata: clarifying behind the Black Curtain. A review on clinical evaluation and management of the 21st century.

Int J Dermatol 2019 Apr 21. Epub 2019 Apr 21.

Departments of Pediatrics, Laboratory Medicine, and Pathology, The University of Alberta, Edmonton, Alberta, Canada.

Melanonychia striata is characterized by a tan, brown, or black longitudinal streak within the nail plate that runs from the proximal nail fold to the distal part of the nail plate. Melanonychia striata is due to increased activity of melanocytes or melanocytic hyperplasia in the nail matrix with subsequently increased melanin deposition in the nail plate. The most common cause of melanonychia striata associated with melanocytic activation is ethnic melanonychia which occurs in dark-skinned individuals. Read More

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http://dx.doi.org/10.1111/ijd.14464DOI Listing

CrossTalk opposing view: Heart rate variability as a measure of cardiac autonomic responsiveness is fundamentally flawed.

J Physiol 2019 Apr 21. Epub 2019 Apr 21.

Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.

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http://dx.doi.org/10.1113/JP277501DOI Listing

Rebuttal from Mark Boyett, Yanwen Wang and Alicia D'Souza.

J Physiol 2019 Apr 21. Epub 2019 Apr 21.

Division of Cardiovascular Sciences, University of Manchester, 46 Grafton Street, Manchester, M13 9NT, UK.

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http://dx.doi.org/10.1113/JP277963DOI Listing

Rebuttal from Marek Malik, Katerina Hnatkova, Heikki V. Huikuri, Federico Lombardi, Georg Schmidt and Markus Zabel.

J Physiol 2019 Apr 21. Epub 2019 Apr 21.

Department of Cardiology and Pneumology, Heart Center - University of Göttingen Medical Center, Göttingen, Germany.

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http://dx.doi.org/10.1113/JP277962DOI Listing

Beyond the borderline.

Lancet Psychiatry 2019 May;6(5):371-372

Cassel Hospital, Richmond, UK; co-President, British and Irish Group for the Study of Personality Disorder.

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http://dx.doi.org/10.1016/S2215-0366(19)30133-6DOI Listing

Use of personal mobile devices to record patient data by Canadian emergency physicians and residents.

CJEM 2019 Apr 22:1-5. Epub 2019 Apr 22.

†Emergency Department,Vancouver General Hospital,Vancouver Coastal Health,Vancouver,BC.

Objective: Use of personal mobile devices to record patient data appears to be increasing, but remains poorly studied. We sought to determine the extent and reasons that Canadian emergency physicians (EPs) and emergency medicine residents use personal mobile devices to record patient data in the emergency department (ED).

Methods: A national survey was distributed to Canadian EPs and residents between 27/02/17 and 23/03/17. Read More

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http://dx.doi.org/10.1017/cem.2019.29DOI Listing

Global REACH 2018.

Hypertension 2019 Apr 22:HYPERTENSIONAHA11912780. Epub 2019 Apr 22.

Centre for Heart, Lung & Vascular Health, Faculty of Health and Social Development, University of British Columbia-Okanagan, Kelowna, Canada (R.L.H., C.A.H., G.B.C., M.M.T., P.N.A.).

Excessive erythrocytosis (EE; hemoglobin concentration [Hb] ≥21 g/dL in adult males) is associated with increased cardiovascular risk in highlander Andeans. We sought to quantify shear stress and assess endothelial function via flow-mediated dilation (FMD) in male Andeans with and without EE. We hypothesized that FMD would be impaired in Andeans with EE after accounting for shear stress and that FMD would improve after isovolemic hemodilution. Read More

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http://dx.doi.org/10.1161/HYPERTENSIONAHA.119.12780DOI Listing

Taking Workplace Health Promotion Global: The Art of Cultural Integration.

Am J Health Promot 2019 May;33(4):629-631

2 International SOS, London, United Kingdom.

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http://dx.doi.org/10.1177/0890117119838101dDOI Listing

Spectroscopic observations on human pigmentation.

Photodermatol Photoimmunol Photomed 2019 Apr 21. Epub 2019 Apr 21.

Al Sabah Hospital, Kuwait.

Background: The main chromophores of human skin are melanins and hemoglobins along with carotenoids, bilirubin and other compounds. In an effort to study the spectral signatures of skin melanin we measured absorption spectra in a variety of situations, including a method to show early signs of re-pigmentation in vitiligo.

Methods: To measure skin in vivo, the essential component was a "Bifurcated Optical Fiber" with one end connected to the light source and the second end connected to the spectrometer while the common end was placed on the skin. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/phpp.12474
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http://dx.doi.org/10.1111/phpp.12474DOI Listing
April 2019
2 Reads

The Bayley-III scale may underestimate neurodevelopmental disability after cardiac surgery in infants†.

Eur J Cardiothorac Surg 2019 Apr 21. Epub 2019 Apr 21.

Department of Cardiothoracic Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Objectives: Neurodevelopmental disability is the most common complication among congenital heart surgery survivors. The Bayley scales are standardized instruments to assess neurodevelopment. The most recent edition (Bayley Scales of Infant and Toddler Development 3rd Edition, Bayley-III) yields better-than-expected scores in typically developing and high-risk infants than the second edition (Bayley Scales of Infant Development 2nd Edition, BSID-II). Read More

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http://dx.doi.org/10.1093/ejcts/ezz123DOI Listing

New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances.

Am J Clin Nutr 2019 Apr 21. Epub 2019 Apr 21.

Monell Chemical Senses Center, Philadelphia, PA.

Background: Individual differences in human perception of sweetness are partly due to genetics; however, which genes are associated with the perception and the consumption of sweet substances remains unclear.

Objective: The aim of this study was to verify previous reported associations within genes involved in the peripheral receptor systems (i.e. Read More

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https://academic.oup.com/ajcn/advance-article/doi/10.1093/aj
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http://dx.doi.org/10.1093/ajcn/nqz043DOI Listing
April 2019
2 Reads

Getting your research funded (and other tips for early career cardiovascular investigators).

Authors:
Metin Avkiran

Cardiovasc Res 2019 Apr 21. Epub 2019 Apr 21.

British Heart Foundation, Medical Directorate, Greater London House, 180 Hampstead Road, London NW1 7AW, UK.

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http://dx.doi.org/10.1093/cvr/cvz080DOI Listing

Could implementation of mifepristone address Canada's urban-rural abortion access disparity: a mixed-methods implementation study protocol.

BMJ Open 2019 Apr 20;9(4):e028443. Epub 2019 Apr 20.

Department of Family & Community Medicine, University of Toronto, Toronto, Ontario, Canada.

Introduction: In January 2017, mifepristone-induced medical abortion was made available in Canada. In this study, we will seek to (1) understand facilitators and barriers to the implementation of mifepristone across Canada, (2) assess the impact of a 'community of practice' clinical and health service support platform and (3) engage in and assess the impact of integrated knowledge translation (iKT) activities aimed to improve health policy, systems and service delivery issues to enhance patient access to mifepristone.

Methods And Analysis: This prospective mixed-methods implementation study will involve a national sample of physicians and pharmacists recruited via an online training programme, professional networks and a purpose-built community of practice website. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-028443DOI Listing

Role of the Deployed Aeromedical Response Team Squadron (DARTS) on Operation RUMAN.

Authors:
Rebecca Woolley

J R Army Med Corps 2019 Apr 20. Epub 2019 Apr 20.

Royal Air Force Brize Norton, Oxfordshire, UK

In September 2017, the British Government called on the military to deliver aid and provide assistance to British Overseas Territories in the Caribbean affected by the devastating category 5 Hurricane, Irma.1 The military and humanitarian operation, named Op RUMAN, saw British military personnel from all services deploy at short notice to assess damage, reinstate vital infrastructure and help islanders get back on their feet as quickly as possible. Members of the Deployed Aeromedical Response Team Squadron (DARTS) were among the first troops deployed to the region. Read More

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http://dx.doi.org/10.1136/jramc-2018-001141DOI Listing

Mind the gap: observation windows to define periods of event ascertainment as a quality control method for longitudinal electronic health record data.

Ann Epidemiol 2019 Mar 4. Epub 2019 Mar 4.

Johns Hopkins University, Baltimore, MD.

Purpose: Use of electronic health records (EHRs) in health research may lead to the false assumption of complete event ascertainment. We estimated "observation windows" (OWs), defined as periods within which the assumption of complete ascertainment of events is more likely to hold, as a quality control approach to reducing the likelihood of this false assumption. We demonstrated the impact of OWs on estimating the rates of type II diabetes mellitus (diabetes) from HIV clinical cohorts. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10472797183054
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http://dx.doi.org/10.1016/j.annepidem.2019.01.015DOI Listing
March 2019
1 Read

1-Year Impact on Medical Practice and Clinical Outcomes of FFR: The ADVANCE Registry.

JACC Cardiovasc Imaging 2019 Mar 17. Epub 2019 Mar 17.

Department of Radiology, Providence Health Care, St. Paul's Hospital, University of British Columbia, Vancouver, Canada.

Objectives: The 1-year data from the international ADVANCE (Assessing Diagnostic Value of Non-invasive FFR in Coronary Care) Registry of patients undergoing coronary computed tomography angiography (CTA) was used to evaluate the relationship of fractional flow reserve derived from coronary CTA (FFR) with downstream care and clinical outcomes.

Background: Guidelines for management of chest pain using noninvasive imaging pathways are based on short- to intermediate-term outcomes.

Methods: Patients (N = 5,083) evaluated for clinically suspected coronary artery disease and in whom atherosclerosis was identified by coronary CTA were prospectively enrolled at 38 international sites from July 15, 2015, to October 20, 2017. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1936878X193022
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http://dx.doi.org/10.1016/j.jcmg.2019.03.003DOI Listing
March 2019
1 Read

Automatic weaning based on individual solid feed intake: Effects on behavior and performance of dairy calves.

J Dairy Sci 2019 Apr 17. Epub 2019 Apr 17.

Animal Welfare Program, Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC, Canada V6T 1Z4. Electronic address:

Calves are typically weaned from milk to solids once they reach a predetermined age or when they are consuming a predetermined intake of solids. The first aim of this study was to compare feeding behavior and performance of calves weaned based on age versus starter intake. The latter method can result in considerable variation in the age at which calves are weaned, so a secondary aim was to compare calves that weaned early or late when weaned based on starter intake. Read More

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http://dx.doi.org/10.3168/jds.2018-15830DOI Listing

A multi-scale data fusion framework for bone age assessment with convolutional neural networks.

Comput Biol Med 2019 Mar 19;108:161-173. Epub 2019 Mar 19.

Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, BC, Canada.

Bone age assessment (BAA) has various clinical applications such as diagnosis of endocrine disorders and prediction of final adult height for adolescents. Recent studies indicate that deep learning techniques have great potential in developing automated BAA methods with significant advantages over the conventional methods based on handcrafted features. In this paper, we propose a multi-scale data fusion framework for bone age assessment with X-ray images based on non-subsampled contourlet transform (NSCT) and convolutional neural networks (CNNs). Read More

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http://dx.doi.org/10.1016/j.compbiomed.2019.03.015DOI Listing
March 2019
1.240 Impact Factor

Heparanase protects the heart against chemical or ischemia/reperfusion injury.

J Mol Cell Cardiol 2019 Apr 17. Epub 2019 Apr 17.

Faculty of Pharmaceutical Sciences, University of British Columbia, 2405 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada. Electronic address:

Although cancer cells use heparanase for tumor metastasis, favourable effects of heparanase have been reported in the management of Alzheimer's disease and diabetes. Indeed, we previously established a protective function for heparanase in the acutely diabetic heart, where it conferred cardiomyocyte resistance to oxidative stress and apoptosis by provoking changes in gene expression. In this study, we tested if overexpression of heparanase can protect the heart against chemically induced or ischemia/reperfusion (I/R) injury. Read More

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http://dx.doi.org/10.1016/j.yjmcc.2019.04.008DOI Listing

Similarity attracts: The role of personality in similarity perceptions and children's attitudes towards refugees.

Br J Dev Psychol 2019 Apr 19. Epub 2019 Apr 19.

Department of Social Psychology, University of Amsterdam, The Netherlands.

Previous research has shown that children's intergroup similarity judgements are based not only on ethnicity but also on other dimensions such as sports interest. The present research investigates the role of personality in perceived similarity between ingroup children and refugee outgroup children. A study was conducted among 9- to 12-year-old children (N = 124) at two elementary schools in the Netherlands. Read More

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http://dx.doi.org/10.1111/bjdp.12285DOI Listing
April 2019
2 Reads

Atomistic and experimental study on thermal conductivity of bulk and porous cerium dioxide.

Sci Rep 2019 Apr 19;9(1):6326. Epub 2019 Apr 19.

Department of Mechanical Engineering, University of Saskatchewan, Saskatoon, Canada.

Cerium dioxide (CeO) is a surrogate material for traditional nuclear fuels and an essential material for a wide variety of industrial applications both in its bulk and nanometer length scale. Despite this fact, the underlying physics of thermal conductivity (k), a crucial design parameter in industrial applications, has not received enough attention. In this article, a systematic investigation of the phonon transport properties was performed using ab initio calculations unified with the Boltzmann transport equation. Read More

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http://dx.doi.org/10.1038/s41598-019-42807-5DOI Listing

Pregnane X receptor activation triggers rapid ATP release in primed macrophages that mediates NLRP3 inflammasome activation.

J Pharmacol Exp Ther 2019 Apr 19. Epub 2019 Apr 19.

University of Calgary;

The pregnane X receptor (PXR) is a ligand-activated nuclear receptor that acts as a xenobiotic sensor, responding to compounds of foreign origin, including pharmaceutical compounds, environmental contaminants and natural products, to induce transcriptional events that regulate drug detoxification and efflux pathways. As such, the PXR is thought to play a key role in the protecting the host from xenobiotic exposure. More recently, the PXR has been reported to regulate the expression of innate immune receptors in the intestine and modulate inflammasome activation in the vasculature. Read More

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http://jpet.aspetjournals.org/lookup/doi/10.1124/jpet.118.25
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http://dx.doi.org/10.1124/jpet.118.255679DOI Listing
April 2019
2 Reads

Flavonol biosynthesis genes and their use in a synthetic biology approach to engineering the plant antidiabetic metabolite montbretin A.

Plant Physiol 2019 Apr 19. Epub 2019 Apr 19.

University of British Columbia CITY: Vancouver STATE: British Columbia POSTAL_CODE: V6T1Z4 Canada [CA]

The plant metabolite montbretin A (MbA) and its simpler precursor mini-MbA are being developed as new drugs against Type-2 diabetes. The only known source for these complex acylated flavonol glycosides is the ornamental plant montbretia (Crocosmia x crocosmiiflora). MbA occurs in small amounts in below-ground storage organs, called corms. Read More

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http://dx.doi.org/10.1104/pp.19.00254DOI Listing

Experiences of trauma-sensitive yoga among inner city youth: A mixed-methods feasibility study.

Complement Ther Clin Pract 2019 May 29;35:62-71. Epub 2019 Jan 29.

Foundry, Vancouver, BC, Canada; Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; Department of Occupational Science and Occupational Therapy, Vancouver, BC, Canada; University of British Columbia, Vancouver, BC, Canada; Centre for Health Evaluation and Outcome Sciences, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.ctcp.2019.01.010DOI Listing

Long-term neurobehavioural symptom reporting following mild, moderate, severe, and penetrating traumatic brain injury in U.S. military service members.

Neuropsychol Rehabil 2019 Apr 19:1-24. Epub 2019 Apr 19.

a Defense and Veterans Brain Injury Center, Walter Reed National Military Medical Center , Bethesda , MD , USA.

The purpose of this study was to examine long-term neurobehavioural symptom reporting following mild, moderate, severe, or penetrating TBI in U.S. military service members and veterans (SMV). Read More

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http://dx.doi.org/10.1080/09602011.2019.1604385DOI Listing

Distribution and Phylogeny of Erythrocytic Necrosis Virus (ENV) in Salmon Suggests Marine Origin.

Viruses 2019 Apr 18;11(4). Epub 2019 Apr 18.

Department of Earth, Ocean and Atmospheric Sciences, University of British Columbia, 2207 Main Mall, Vancouver, BC V6T 1Z4, Canada.

Viral erythrocytic necrosis (VEN) affects over 20 species of marine and anadromous fishes in the North Atlantic and North Pacific Oceans. However, the distribution and strain variation of its viral causative agent, erythrocytic necrosis virus (ENV), has not been well characterized within Pacific salmon. Here, metatranscriptomic sequencing of Chinook salmon revealed that ENV infecting salmon was closely related to ENV from Pacific herring, with inferred amino-acid sequences from Chinook salmon being 99% identical to those reported for herring. Read More

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https://www.mdpi.com/1999-4915/11/4/358
Publisher Site
http://dx.doi.org/10.3390/v11040358DOI Listing
April 2019
1 Read

Sensitivity Enhancement of Silicon-on-Insulator CMOS MEMS Thermal Hot-Film Flow Sensors by Minimizing Membrane Conductive Heat Losses.

Sensors (Basel) 2019 Apr 18;19(8). Epub 2019 Apr 18.

Engineering Department, University of Cambridge, Cambridge CB3 0FA, UK.

Minimizing conductive heat losses in Micro-Electro-Mechanical-Systems (MEMS) thermal (hot-film) flow sensors is the key to minimize the sensors' power consumption and maximize their sensitivity. Through a comprehensive review of literature on MEMS thermal (calorimetric, time of flight, hot-film/hot-film) flow sensors published during the last two decades, we establish that for curtailing conductive heat losses in the sensors, researchers have either used low thermal conductivity substrate materials or, as a more effective solution, created low thermal conductivity membranes under the heaters/hot-films. However, no systematic experimental study exists that investigates the effect of membrane shape, membrane size, heater/hot-film length and M e m b r a n e (size) to H e a t e r (hot-film length) () on sensors' conductive heat losses. Read More

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http://dx.doi.org/10.3390/s19081860DOI Listing

Bioaccessibility estimates by gastric SBRC method to determine relationships to bioavailability of nickel in ultramafic soils.

Sci Total Environ 2019 Apr 6;673:685-693. Epub 2019 Apr 6.

School of Environmental Sciences, University of Guelph, Guelph, ON, Canada.

Frameworks for human health risk assessment often include the opportunity to correct the estimate of exposure for bioavailability, which could be predicted from bioaccessibility. Lead and As are the only metallic elements for which bioavailability and bioaccessibility have been correlated across a spectrum of mineralogy and particle types. The objective of the present study is to correlate in vivo bioavailability with ex vivo bioaccessibility for elevated Ni in soils of ultramafic origin and explore attribution of any variation in this correlation to mineralogical characterization of the Ni. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.04.059DOI Listing

Instance-of-object-kind representations.

Cognition 2019 Apr 16;189:209-220. Epub 2019 Apr 16.

Department of Psychology, University of British Columbia, Canada.

We naturally think and talk about the objects we encounter as instances of one or another kind of object (e.g. as a dog). Read More

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http://dx.doi.org/10.1016/j.cognition.2019.04.002DOI Listing

First Real-World Safety Analysis of Preschool Peanut Oral Immunotherapy.

J Allergy Clin Immunol Pract 2019 Apr 17. Epub 2019 Apr 17.

British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Division of Allergy and Immunology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.

Background: In 2017, a clinical trial of 37 subjects demonstrated that preschool peanut oral immunotherapy (P-OIT) was safe, with predominantly mild symptoms reported and only 1 moderate reaction requiring epinephrine.

Objectives: We sought to examine whether these findings would be applicable in a real-world setting.

Methods: As part of a Canada-wide quality improvement project, academic and community allergists administered P-OIT to preschool-age children who had (1) skin prick test wheal diameter greater than or equal to 3 mm or specific IgE level greater than or equal to 0. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.04.010DOI Listing
April 2019
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Real-world treatment of stage III NSCLC: the role of trimodality treatment in the era of immunotherapy.

J Thorac Oncol 2019 Apr 16. Epub 2019 Apr 16.

University of British Columbia, 2329 West Mall, Vancouver, BC, Canada V6T 1Z4; Department of Medical Oncology, BC Cancer, 600 W 10th Avenue, Vancouver, BC, Canada V5Z 4E6. Electronic address:

Introduction: Curative intent treatment of stage III NSCLC is variable and influenced by both patient and disease characteristics. We performed a real-world analysis of curative therapies in stage III NSCLC, and explored the impact of known prognostic factors on outcome.

Methods: A retrospective review was completed of all patients with stage III NSCLC between January 2005 and December 2012. Read More

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http://dx.doi.org/10.1016/j.jtho.2019.04.005DOI Listing

Intermittent hypoxia impairs uterine artery function in pregnant mice.

J Physiol 2019 Apr 19. Epub 2019 Apr 19.

Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, Canada.

Key Points: Obstructive sleep apnoea (OSA) is a chronic condition characterized by intermittent hypoxia that induces oxidative stress and inflammation leading to cardiovascular disease. Women can develop OSA during late pregnancy, which is associated with adverse maternal and fetal outcomes. However, the effects of OSA throughout pregnancy on fetoplacental outcomes are unknown. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1113/JP277775
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http://dx.doi.org/10.1113/JP277775DOI Listing
April 2019
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Epigenetic regulator G9a provides glucose as a sweet key to stress resistance.

PLoS Biol 2019 Apr 19;17(4):e3000236. Epub 2019 Apr 19.

Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, The University of British Columbia, Vancouver, British Columbia, Canada.

The ability to adapt to acute and chronic stress is important for organisms to thrive in evolutionary niches and for cells to survive in adverse conditions. The regulatory networks that control stress responses are evolutionarily conserved, and many factors that selectively activate stress responses have been identified. Less well understood are mechanisms that guard against unnecessary induction of cytoprotective factors and that connect stress responses with cellular metabolism to control energy expenditure during stress. Read More

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http://dx.plos.org/10.1371/journal.pbio.3000236
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http://dx.doi.org/10.1371/journal.pbio.3000236DOI Listing
April 2019
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Response to Letter to the Editor.

Authors:
Nigel S B Rawson

J Popul Ther Clin Pharmacol 2019 Jan 22;26(1):e20-e21. Epub 2019 Jan 22.

Eastlake Research Group, Oakville, Ontario; Canadian Health Policy Institute, Toronto; Ontario; Fraser Institute, Vancouver, British Columbi.

Author's response to comments from Dr Lexchin's Letter to the Editor regarding our article. Read More

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http://jptcp.com/index.php/jptcp/article/view/394
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http://dx.doi.org/10.22374/1710-6222.26.1.2DOI Listing
January 2019
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