36,527 results match your criteria British journal of medical & surgical urology[Journal]


Depression in Neurodegenerative Diseases: Common Mechanisms and Current Treatment Options.

Neurosci Biobehav Rev 2019 Apr 14. Epub 2019 Apr 14.

Island Medical Program, University of British Columbia, Victoria, BC, Canada; Division of Medical Sciences, University of Victoria, Victoria, BC, Canada. Electronic address:

Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major cause of disability worldwide. This neurological condition is commonly associated with neurodegenerative diseases such as Alzheimer's Disease (AD), Parkinson's Disease (PD) and Huntington's Disease (HD), and has a significant impact on the increasing burden of these neuropathologies. Over the past decades, some of the pathophysiological and molecular mechanisms that contribute to these diseases have been elucidated and these findings indicate that, despite presenting distinct features, there are several similarities between the neurobiological alterations that lead to MDD and neurodegeneration in AD, PD and HD. Read More

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http://dx.doi.org/10.1016/j.neubiorev.2019.04.002DOI Listing

On Histologic Variability of HPV-associated Endocervical Adenocarcinomas.

Am J Surg Pathol 2019 Apr 15. Epub 2019 Apr 15.

Department of Pathology, University of British Columbia, Royal Columbian Hospital, Vancouver, BC, Canada.

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http://dx.doi.org/10.1097/PAS.0000000000001259DOI Listing

Children under 10 years of age were more affected by the 2018/19 influenza A(H1N1)pdm09 epidemic in Canada: ‎possible cohort effect following the 2009 influenza pandemic.

Euro Surveill 2019 Apr;24(15)

University of Toronto, Toronto, Canada.

IntroductionFindings from the community-based Canadian Sentinel Practitioner Surveillance Network (SPSN) suggest children were more affected by the 2018/19 influenza A(H1N1)pdm09 epidemic.AimTo compare the age distribution of A(H1N1)pdm09 cases in 2018/19 to prior seasonal influenza epidemics in Canada.MethodsThe age distribution of unvaccinated influenza A(H1N1)pdm09 cases and test-negative controls were compared across A(H1N1)pdm09-dominant epidemics in 2018/19, 2015/16 and 2013/14 and with the general population of SPSN provinces. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2019.24.15.1900104DOI Listing
April 2019
2 Reads

Medical Information Commons to Support Learning Healthcare Systems: Examples From Canada.

J Law Med Ethics 2019 Mar;47(1):97-105

Tania Bubela, Ph.D., J.D., F.C.A.H.S., is an expert in health and intellectual property law and policy, combining her training in genetics (Ph.D. Biology, University of Sydney) and law (Gold medalist, University of Alberta). She is the Dean of Faculty of Health Sciences at Simon Fraser University (Burnaby, British Columbia), developing sector-leading policies, processes, practices, and infrastructure to support excellence in interdisciplinary education, research, and engagement that will improve health, health equity, and well-being. Shelagh K. Genuis, Ph.D., is the project manager for the Genome Canada's Precision Medicine Policy Network, based in the Faculty of Medicine and Dentistry at the University of Alberta, Alberta. Naveed Z. Janjua, M.D., Ph.D., is a Senior Scientist at the BC Centre for Disease Control and Clinical Associate Professor at School of Population and Public Health, University of British Columbia. Mel Krajden, M.D., F.R.C.P.C., is the Director of BC's Public Health Laboratory and the Medical Head, Hepatitis at the British Columbia Centre for Disease Control. He is also a Professor of Pathology and Laboratory Medicine at the University of British Columbia. He has extensive clinical trials expertise and is a Co-investigator/Mentor on the CIHR funded National Research Training Program (CanHepC). Nicole Mittmann, Ph.D., is the Chief Research Officer at CCO. She is an Assistant Professor at the University of Toronto in the Department of Pharmacology and Toxicology and an Associate Scientist at Sunnybrook Health Sciences Centre. Katerina Podolak is the Group Manager for Data Acquisition and Disclosure at Cancer Care Ontario, working with data partners to bring data into CCO, and health system partners who want access to CCO data. Katerina has extensive experience with information management in the hospital setting, as well as Ontario's Ministry of Health and Long-term Care. Larry Svenson, Ph.D., F.R.S.P.H., is the Provincial Health Analytics Officer and Executive Director for Analytics and Performance Reporting at Alberta Health. He is also an Associate Professor with the Division of Preventive Medicine at the University of Alberta and an Adjunct Professor with the School of Public Health at the University of Alberta and the Cumming School of Medicine at the University of Calgary.

We explore how principles predicting the success of a medical information commons (MIC) advantaged or disadvantaged three MIC initiatives in three Canadian provinces. Our MIC case examples demonstrate that practices and policies to promote access to and use of health information can help improve individual healthcare and inform a learning health system. MICs were constrained by heterogenous health information protection laws across jurisdictions and risk-averse institutional cultures. Read More

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http://dx.doi.org/10.1177/1073110519840488DOI Listing

A consensus redefinition of transfusion-related acute lung injury.

Transfusion 2019 Apr 16. Epub 2019 Apr 16.

Department of Pathology, University British Columbia, Vancouver, British Columbia, Canada.

Background: Transfusion-related acute lung injury (TRALI) is a serious complication of blood transfusion and is among the leading causes of transfusion-related morbidity and mortality in most developed countries. In the past decade, the pathophysiology of this potentially life-threatening syndrome has been increasingly elucidated, large cohort studies have identified associated patient conditions and transfusion risk factors, and preventive strategies have been successfully implemented. These new insights provide a rationale for updating the 2004 consensus definition of TRALI. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/trf.15311
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http://dx.doi.org/10.1111/trf.15311DOI Listing
April 2019
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Entrustment Ratings in Internal Medicine Training: Capturing Meaningful Supervision Decisions or Just Another Rating?

J Gen Intern Med 2019 Apr 16. Epub 2019 Apr 16.

Northern Medical Program, University of Northern British Columbia, Prince George, Canada.

The implementation of Entrustable Professional Activities has led to the simultaneous development of assessment based on a supervisor's entrustment of a learner to perform these activities without supervision. While entrustment may be intuitive when we consider the direct observation of a procedural task, the current implementation of rating scales for internal medicine's non-procedural tasks, based on entrustability, may not translate into meaningful learner assessment. In these Perspectives, we outline a number of potential concerns with ad hoc entrustability assessments in internal medicine post-graduate training: differences in the scope of procedural vs. Read More

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http://dx.doi.org/10.1007/s11606-019-04878-yDOI Listing

[From symptom to diagnosis-symptom checkers re-evaluated : Are symptom checkers finally sufficient and accurate to use? An update from the ENT perspective].

HNO 2019 Apr 16. Epub 2019 Apr 16.

Symptoma GmbH, Neuhofen 5, 4864, Attersee am Attersee, Österreich.

Background: Every seventh diagnosis is a misdiagnosis. Each year, 1.5 million lives could be saved worldwide with the correct diagnosis. Read More

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http://dx.doi.org/10.1007/s00106-019-0666-yDOI Listing

Long-term prognostic utility of computed tomography coronary angiography in older populations.

Eur Heart J Cardiovasc Imaging 2019 Apr 16. Epub 2019 Apr 16.

Department of Radiology, New York-Presbyterian Hospital and Weill Cornell Medicine, New York, NY, USA.

Aims: The long-term prognostic value of coronary computed tomography angiography (CCTA)-identified coronary artery disease (CAD) has not been evaluated in elderly patients (≥70 years). We compared the ability of coronary CCTA to predict 5-year mortality in older vs. younger populations. Read More

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http://dx.doi.org/10.1093/ehjci/jez067DOI Listing

Multi-platform discovery of haplotype-resolved structural variation in human genomes.

Nat Commun 2019 Apr 16;10(1):1784. Epub 2019 Apr 16.

The Jackson Laboratory for Genomic Medicine, Farmington, CT, 06032, USA.

The incomplete identification of structural variants (SVs) from whole-genome sequencing data limits studies of human genetic diversity and disease association. Here, we apply a suite of long-read, short-read, strand-specific sequencing technologies, optical mapping, and variant discovery algorithms to comprehensively analyze three trios to define the full spectrum of human genetic variation in a haplotype-resolved manner. We identify 818,054 indel variants (<50 bp) and 27,622 SVs (≥50 bp) per genome. Read More

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http://www.nature.com/articles/s41467-018-08148-z
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http://dx.doi.org/10.1038/s41467-018-08148-zDOI Listing
April 2019
1 Read

Romaine Amiel: a French surgeon in the British Army during the Napoleonic Wars.

J R Army Med Corps 2019 Apr 16. Epub 2019 Apr 16.

Academic Clinical Fellow, Academic Department of Military General Practice, Birmingham, UK

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http://dx.doi.org/10.1136/jramc-2019-001223DOI Listing

Provisional Validation of a Pediatric Early Warning Score for Resource-Limited Settings.

Pediatrics 2019 Apr 16. Epub 2019 Apr 16.

Department of Pediatrics, School of Medicine, Yale University, New Haven, Connecticut.

Background And Objectives: The use of Pediatric Early Warning Scores is becoming widespread to identify and rapidly respond to patients with deteriorating conditions. The ability of Pediatric Early Warning Scores to identify children at high risk of deterioration or death has not, however, been established in resource-limited settings.

Methods: We developed the Pediatric Early Warning Score for Resource-Limited Settings (PEWS-RL) on the basis of expert opinion and existing scores. Read More

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http://dx.doi.org/10.1542/peds.2018-3657DOI Listing

The 'Scientific' phrenologist - Bernard Hollander (1864-1934).

Authors:
David F McEniery

J Med Biogr 2019 Apr 16:967772019840170. Epub 2019 Apr 16.

The University of Queensland, Brisbane, Australia.

Bernard Hollander (1864-1934), a Viennese-born British physician, scientist, and author, was best known for his late 19th century and early 20th century revival of a 'Scientific Phrenology'. Hollander, motivated by the advances in cerebral localisation and neuroscience that appeared to justify Franz Joseph Gall's (1758-1828) initial interests in craniology, hoped to use this new framework to substantively improve the lot of his patients and his community. Ridiculed and derided by his colleagues while maintaining a measure of public prominence, Hollander discussed contemporary issues including notions of human nature, mental illness, education, development, women's rights, and sociobiology. Read More

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http://dx.doi.org/10.1177/0967772019840170DOI Listing

An observational cohort study of exercise and education for people with chronic obstructive pulmonary disease not meeting criteria for formal pulmonary rehabilitation programmes.

Chron Respir Dis 2019 Jan-Dec;16:1479973119838283

1 National Heart and Lung Institute, Imperial College London, London, UK.

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality. Pulmonary rehabilitation (PR) is offered to patients with functional breathlessness. However, access to PR is limited. Read More

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http://dx.doi.org/10.1177/1479973119838283DOI Listing

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy.

N Engl J Med 2019 Apr 14. Epub 2019 Apr 14.

From the George Institute for Global Health, University of New South Wales Sydney (V.P., M.J.J., B.N., S. Bompoint), the Royal North Shore Hospital (V.P.), Concord Repatriation General Hospital (M.J.J.), and the Charles Perkins Centre, University of Sydney (B.N.), Sydney, and the Kolling Institute of Medical Research, Sydney Medical School, University of Sydney, Royal North Shore Hospital, St. Leonards, NSW (C.P.) - all in Australia; Imperial College London (B.N.) and the Department of Renal Medicine, UCL Medical School (D.C.W.) - both in London; the Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands (H.J.L.H., D.Z.); the Nephrology Division, NYU School of Medicine and NYU Langone Medical Center, New York (D.M.C.); Baim Institute for Clinical Research (D.M.C., C.P.C., B.M.B.), the Cardiovascular Division (C.P.C.) and the Renal Division and Department of Medicine (B.M.B), Brigham and Women's Hospital, and Harvard Medical School (B.M.B.) - all in Boston; Janssen Research and Development, Raritan, NJ (R.E., S. Bull, G.C., P.-L.C., Y.Y., G.M.); Indiana University School of Medicine and Veterans Affairs Medical Center, Indianapolis (R.A.); the Department of Medicine, University of Chicago Medicine, Chicago (G.B.); the Division of Biostatistics, Department of Population Health Sciences, University of Utah, Salt Lake City (T.G.); the Division of Nephrology, University of British Columbia, Vancouver (A.L.), and the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto (B.Z.) - all in Canada; the Renal Division, Peking University First Hospital, Beijing (H.Z.); and the Stanford Center for Clinical Research, Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.).

Background: Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium-glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes.

Methods: In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1811744
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http://dx.doi.org/10.1056/NEJMoa1811744DOI Listing
April 2019
1 Read

Assigning Medical Students Learning Goals: Do They Do It, and What Happens When They Don't?

Teach Learn Med 2019 Apr 16:1-8. Epub 2019 Apr 16.

a Wilson Centre , University Health Network ; Faculty of Medicine , University of Toronto , Toronto , Ontario , Canada.

Theory: Medical curricula now include more time for trainees to manage their studying independently, yet evidence suggests that time is not well spent without guidance. Social-cognitivist models of self-regulated learning suggest value when guiding learners to set goals related to their performance processes (actions producing outcomes) versus their performance outcomes (products of performance).

Hypotheses: We expected participants oriented to set process goals would demonstrate better suturing skill retention compared with participants oriented to set outcome goals. Read More

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http://dx.doi.org/10.1080/10401334.2019.1600520DOI Listing
April 2019
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Review article: A primer for clinical researchers in the emergency department: Part IX. How to conduct a systematic review in the field of emergency medicine.

Emerg Med Australas 2019 Apr 15. Epub 2019 Apr 15.

Cochrane Hypertension Group, Department of Anesthesiology, Pharmacology, and Therapeutics, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.

In this series we address important topics for emergency clinicians who either participate in research as part of their work, or use the knowledge generated by research studies. Emergency clinicians are routinely in the position of applying new evidence in clinical practice. With an ever-increasing volume of evidence generated, this can be problematic when studies are conducted in different settings, and include different patient groups, different interventions and different outcomes. Read More

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http://dx.doi.org/10.1111/1742-6723.13298DOI Listing

The spatial correspondence and genetic influence of interhemispheric connectivity with white matter microstructure.

Nat Neurosci 2019 Apr 15. Epub 2019 Apr 15.

Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom.

Microscopic features (that is, microstructure) of axons affect neural circuit activity through characteristics such as conduction speed. To what extent axonal microstructure in white matter relates to functional connectivity (synchrony) between brain regions is largely unknown. Using MRI data in 11,354 subjects, we constructed multivariate models that predict functional connectivity of pairs of brain regions from the microstructural signature of white matter pathways that connect them. Read More

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http://www.nature.com/articles/s41593-019-0379-2
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http://dx.doi.org/10.1038/s41593-019-0379-2DOI Listing
April 2019
1 Read

Ancient genomes indicate population replacement in Early Neolithic Britain.

Nat Ecol Evol 2019 Apr 15. Epub 2019 Apr 15.

Department of Earth Sciences, Natural History Museum, London, UK.

The roles of migration, admixture and acculturation in the European transition to farming have been debated for over 100 years. Genome-wide ancient DNA studies indicate predominantly Aegean ancestry for continental Neolithic farmers, but also variable admixture with local Mesolithic hunter-gatherers. Neolithic cultures first appear in Britain circa 4000 BC, a millennium after they appeared in adjacent areas of continental Europe. Read More

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http://www.nature.com/articles/s41559-019-0871-9
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http://dx.doi.org/10.1038/s41559-019-0871-9DOI Listing
April 2019
4 Reads

Genome-wide association and transcriptome studies identify target genes and risk loci for breast cancer.

Authors:
Manuel A Ferreira Eric R Gamazon Fares Al-Ejeh Kristiina Aittomäki Irene L Andrulis Hoda Anton-Culver Adalgeir Arason Volker Arndt Kristan J Aronson Banu K Arun Ella Asseryanis Jacopo Azzollini Judith Balmaña Daniel R Barnes Daniel Barrowdale Matthias W Beckmann Sabine Behrens Javier Benitez Marina Bermisheva Katarzyna Białkowska Carl Blomqvist Natalia V Bogdanova Stig E Bojesen Manjeet K Bolla Ake Borg Hiltrud Brauch Hermann Brenner Annegien Broeks Barbara Burwinkel Trinidad Caldés Maria A Caligo Daniele Campa Ian Campbell Federico Canzian Jonathan Carter Brian D Carter Jose E Castelao Jenny Chang-Claude Stephen J Chanock Hans Christiansen Wendy K Chung Kathleen B M Claes Christine L Clarke Fergus J Couch Angela Cox Simon S Cross Kamila Czene Mary B Daly Miguel de la Hoya Joe Dennis Peter Devilee Orland Diez Thilo Dörk Alison M Dunning Miriam Dwek Diana M Eccles Bent Ejlertsen Carolina Ellberg Christoph Engel Mikael Eriksson Peter A Fasching Olivia Fletcher Henrik Flyger Eitan Friedman Debra Frost Marike Gabrielson Manuela Gago-Dominguez Patricia A Ganz Susan M Gapstur Judy Garber Montserrat García-Closas José A García-Sáenz Mia M Gaudet Graham G Giles Gord Glendon Andrew K Godwin Mark S Goldberg David E Goldgar Anna González-Neira Mark H Greene Jacek Gronwald Pascal Guénel Christopher A Haiman Per Hall Ute Hamann Wei He Jane Heyworth Frans B L Hogervorst Antoinette Hollestelle Robert N Hoover John L Hopper Peter J Hulick Keith Humphreys Evgeny N Imyanitov Claudine Isaacs Milena Jakimovska Anna Jakubowska Paul A James Ramunas Janavicius Rachel C Jankowitz Esther M John Nichola Johnson Vijai Joseph Beth Y Karlan Elza Khusnutdinova Johanna I Kiiski Yon-Dschun Ko Michael E Jones Irene Konstantopoulou Vessela N Kristensen Yael Laitman Diether Lambrechts Conxi Lazaro Goska Leslie Jenny Lester Fabienne Lesueur Sara Lindström Jirong Long Jennifer T Loud Jan Lubiński Enes Makalic Arto Mannermaa Mehdi Manoochehri Sara Margolin Tabea Maurer Dimitrios Mavroudis Lesley McGuffog Alfons Meindl Usha Menon Kyriaki Michailidou Austin Miller Marco Montagna Fernando Moreno Lidia Moserle Anna Marie Mulligan Katherine L Nathanson Susan L Neuhausen Heli Nevanlinna Ines Nevelsteen Finn C Nielsen Liene Nikitina-Zake Robert L Nussbaum Kenneth Offit Edith Olah Olufunmilayo I Olopade Håkan Olsson Ana Osorio Janos Papp Tjoung-Won Park-Simon Michael T Parsons Inge Sokilde Pedersen Ana Peixoto Paolo Peterlongo Paul D P Pharoah Dijana Plaseska-Karanfilska Bruce Poppe Nadege Presneau Paolo Radice Johanna Rantala Gad Rennert Harvey A Risch Emmanouil Saloustros Kristin Sanden Elinor J Sawyer Marjanka K Schmidt Rita K Schmutzler Priyanka Sharma Xiao-Ou Shu Jacques Simard Christian F Singer Penny Soucy Melissa C Southey John J Spinelli Amanda B Spurdle Jennifer Stone Anthony J Swerdlow William J Tapper Jack A Taylor Manuel R Teixeira Mary Beth Terry Alex Teulé Mads Thomassen Kathrin Thöne Darcy L Thull Marc Tischkowitz Amanda E Toland Diana Torres Thérèse Truong Nadine Tung Celine M Vachon Christi J van Asperen Ans M W van den Ouweland Elizabeth J van Rensburg Ana Vega Alessandra Viel Qin Wang Barbara Wappenschmidt Jeffrey N Weitzel Camilla Wendt Robert Winqvist Xiaohong R Yang Drakoulis Yannoukakos Argyrios Ziogas Peter Kraft Antonis C Antoniou Wei Zheng Douglas F Easton Roger L Milne Jonathan Beesley Georgia Chenevix-Trench

Nat Commun 2019 Apr 15;10(1):1741. Epub 2019 Apr 15.

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.

Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several with a known immune function. Read More

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http://dx.doi.org/10.1038/s41467-018-08053-5DOI Listing

Low-dose agalsidase beta treatment in male pediatric patients with Fabry disease: A 5-year randomized controlled trial.

Mol Genet Metab 2019 Apr 3. Epub 2019 Apr 3.

Department of Pediatric Metabolic Diseases, Emma Children's Hospital and Amsterdam Lysosome Center "Sphinx", Academic Medical Center, University Hospital of Amsterdam, Amsterdam, the Netherlands.

Background: Fabry disease is a rare, X-linked, lifelong progressive lysosomal storage disorder. Severely deficient α-galactosidase A activity in males is associated with the classic phenotype with early-onset, multisystem manifestations evolving to vital organ complications during adulthood. We assessed the ability of 2 low-dose agalsidase beta regimens to lower skin, plasma, and urine globotriaosylceramide (GL-3) levels, and influence clinical manifestations in male pediatric Fabry patients. Read More

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http://dx.doi.org/10.1016/j.ymgme.2019.03.010DOI Listing

Proteases and their inhibitors as prognostic factors for high-grade serous ovarian cancer.

Pathol Res Pract 2019 Mar 2. Epub 2019 Mar 2.

Laval University Cancer Research Center and Research Center of the Centre Hospitalier Universitaire (CHU) de Québec, Ville de Québec, QC, G1R 3S3, Canada.

Ovarian carcinoma is one of the most lethal malignancies, but only very few prognostic biomarkers are known. The degradome, comprising proteases, protease non-proteolytic homologues and inhibitors, have been involved in the prognosis of many cancer types, including ovarian carcinoma. The prognostic significance of the whole degradome family has not been specifically studied in high-grade serous ovarian cancer. Read More

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http://dx.doi.org/10.1016/j.prp.2019.02.019DOI Listing
March 2019
2 Reads

The Hidden Cost of Modern Medical Interventions: How Medical Advances Have Shaped the Prevalence of Human Fungal Disease.

Pathogens 2019 Apr 4;8(2). Epub 2019 Apr 4.

Institute of Immunology & Immunotherapy, Institute of Microbiology & Infection, University of Birmingham, Birmingham B15 2TT, UK.

Life expectancy in the West is the highest it has ever been, due to the introduction of better hygiene practices and sophisticated medical interventions for cancer, autoimmunity and infectious disease. With these modern advances, a rise in the prevalence of opportunistic infections has also been observed. These include several fungal infections, which present a particular clinical challenge due to the lack of fungal vaccines, limited diagnostics and increasing antifungal drug resistance. Read More

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http://dx.doi.org/10.3390/pathogens8020045DOI Listing

Duration of Oxaliplatin-Containing Adjuvant Therapy for Stage III Colon Cancer: ASCO Clinical Practice Guideline.

J Clin Oncol 2019 Apr 15:JCO1900281. Epub 2019 Apr 15.

15 St Michael's Hospital, Toronto, Ontario, Canada.

Purpose: To develop recommendations for duration of adjuvant chemotherapy with a fluoropyrimidine and oxaliplatin for patients with completely resected stage III colon cancer based on the results of trials of 3 months compared with 6 months of treatment.

Methods: ASCO convened an Expert Panel and conducted a systematic review of relevant studies. The guideline recommendations were based on the review of evidence by the Expert Panel. Read More

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http://dx.doi.org/10.1200/JCO.19.00281DOI Listing

Toward Completion of the Human Proteome Parts List: Progress Uncovering Proteins That Are Missing or Have Unknown Function and Developing Analytical Methods.

J Proteome Res 2018 Dec;17(12):4023-4030

Institute for Systems Biology, Departments of Computational Medicine & Bioinformatics, Internal Medicine, and Human Genetics & School of Public Health, University of Michigan.

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http://dx.doi.org/10.1021/acs.jproteome.8b00885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288998PMC
December 2018

Personality-obesity associations are driven by narrow traits: A meta-analysis.

Obes Rev 2019 Apr 15. Epub 2019 Apr 15.

Institute of Psychology, University of Tartu, Tartu, Estonia.

Obesity has inconsistent associations with broad personality domains, possibly because the links pertain to only some facets of these domains. Collating published and unpublished studies (N = 14 848), we meta-analysed the associations between body mass index (BMI) and Five-Factor Model personality domains as well as 30 Five-Factor Model personality facets. At the domain level, BMI had a positive association with Neuroticism and a negative association with Conscientiousness domains. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/obr.12856
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http://dx.doi.org/10.1111/obr.12856DOI Listing
April 2019
1 Read

Neuroimaging biomarkers for clinical trials in atypical parkinsonian disorders: Proposal for a Neuroimaging Biomarker Utility System.

Alzheimers Dement (Amst) 2019 Dec 2;11:301-309. Epub 2019 Apr 2.

Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.

Introduction: Therapeutic strategies targeting protein aggregations are ready for clinical trials in atypical parkinsonian disorders. Therefore, there is an urgent need for neuroimaging biomarkers to help with the early detection of neurodegenerative processes, the early differentiation of the underlying pathology, and the objective assessment of disease progression. However, there currently is not yet a consensus in the field on how to describe utility of biomarkers for clinical trials in atypical parkinsonian disorders. Read More

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http://dx.doi.org/10.1016/j.dadm.2019.01.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446052PMC
December 2019

Validation of Three-dimensional Electronic Portal Imaging Device-based PerFRACTION™ Software for Patient-Specific Quality Assurance.

J Med Phys 2019 Jan-Mar;44(1):16-20

Department of Medical Physics, BC Cancer Agency-Abbotsford Cancer Center, British Columbia, Canada.

Purpose: PerFRACTION™ is a three-dimensional (3D) electronic portal imaging device-based dosimetry software. To validate the software, three phantoms with different inserts (2D array, ionization chamber, and inhomogeneity materials) were constructed to evaluate point dose and fluence map.

Materials And Methods: Phantoms underwent independent computed tomography simulation for planning and received repetitive fractions of volumetric modulated arc therapy, simulating prostate treatment. Read More

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http://dx.doi.org/10.4103/jmp.JMP_76_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438053PMC

Link between insomnia and perinatal depressive symptoms: A meta-analysis.

J Sleep Res 2019 Apr 14:e12858. Epub 2019 Apr 14.

Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Evidence shows the possible link between insomnia and perinatal depressive symptoms. In order to find a convergent quantitative answer, we collected data via the search of Medline, EMBASE and reference tracking, which included nine studies (a total sample of 1,922 women). An aggregate effect size estimate (correlation coefficient) was generated using the comprehensive meta-analysis software. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/jsr.12858
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http://dx.doi.org/10.1111/jsr.12858DOI Listing
April 2019
1 Read

Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies.

Am J Clin Nutr 2019 Apr;109(4):1216-1223

Cardiovascular Health Research Unit.

Background: Saturated fatty acids (SFAs) of different chain lengths have unique metabolic and biological effects, and a small number of recent studies suggest that higher circulating concentrations of the very-long-chain SFAs (VLSFAs) arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) are associated with a lower risk of diabetes. Confirmation of these findings in a large and diverse population is needed.

Objective: We investigated the associations of circulating VLSFAs 20:0, 22:0, and 24:0 with incident type 2 diabetes in prospective studies. Read More

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http://dx.doi.org/10.1093/ajcn/nqz005DOI Listing
April 2019
6.770 Impact Factor

Autophagy and Cancer Research in Iran.

Autophagy 2019 Apr 14. Epub 2019 Apr 14.

b Autophagy Research Center, Health Policy Research Center, Institute of Health , Shiraz University of Medical Sciences ; Shiraz , Iran.

In August 2018, three events were held in Iran on clinical biochemistry, molecular biology, cancer/autophagy, laboratory management, and proteomics. On August 25-28 at the Isfahan University of Medical Sciences, the 15 National Biochemistry Congress and the 6 International Congress on Biochemistry and Molecular Biology were held, gathering together international professors from Canada, the USA, Germany, Australia, Italy, France, and Sweden, as well as Iran to discuss mainly the roles of autophagy in cancer therapy. On August 29, a one-day "Autophagy" symposium was held at the Shiraz University of Medical Sciences. Read More

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https://www.tandfonline.com/doi/full/10.1080/15548627.2019.1
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http://dx.doi.org/10.1080/15548627.2019.1606638DOI Listing
April 2019
1 Read

Associations between long-term adherence to healthy diet and recurrent depressive symptoms in Whitehall II Study.

Eur J Nutr 2019 Apr 13. Epub 2019 Apr 13.

Inserm, U1198, University of Montpellier, Ecole Pratique des Hautes Etudes, PSL Research University, Montpellier, 34095, France.

Purpose: We examined whether long-term adherence to three diet quality scores-the Alternative Healthy Eating Index-2010 (AHEI-2010), Dietary Approach to Stop Hypertension (DASH) and  transformed-Mediterranean Diet Score (tMDS), Alternative Healthy Eating Index-2010 (AHEI-2010) and Dietary Approach to Stop Hypertension (DASH) is associated with the risk of recurrent depressive symptoms.

Methods: Analyses were conducted on a sample of 4949 men and women from the Whitehall II study. Diet scores were calculated using data collected from food frequency questionnaires repeated over 11 years of exposure (1991/1993-2002/2004). Read More

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http://dx.doi.org/10.1007/s00394-019-01964-zDOI Listing

Childbirth and prevention of bipolar disorder: an opportunity for change.

Lancet Psychiatry 2019 Apr 10. Epub 2019 Apr 10.

Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.

The recent conceptualisation of bipolar disorder as a neuroprogressive illness has highlighted the potential importance of prevention and early intervention in high-risk populations. Undiagnosed bipolar disorder early in the disease course is associated with adverse clinical outcomes and impaired functioning for patients, which in turn has economic consequences. Despite the mounting evidence that childbirth is one of the most potent and specific triggers of manic symptoms, studies are not available on the effectiveness of targeted interventions in the prevention of bipolar disorder in women who have recently given birth. Read More

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http://dx.doi.org/10.1016/S2215-0366(19)30092-6DOI Listing

Prior Pacemaker Implantation and Clinical Outcomes in Patients With Heart Failure and Preserved Ejection Fraction.

JACC Heart Fail 2019 Apr 3. Epub 2019 Apr 3.

British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, Scotland, United Kingdom. Electronic address:

Objectives: This study examined the relationship between prior pacemaker implantation and clinical outcomes in patients with heart failure with preserved ejection fraction (HFpEF).

Background: Conventional right ventricular pacing causes electrical and mechanical left ventricular dys-synchrony and may worsen left ventricular systolic dysfunction and HF. Whether conventional pacing is also associated with worse outcomes in HFpEF is unknown. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22131779183091
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http://dx.doi.org/10.1016/j.jchf.2018.12.006DOI Listing
April 2019
8 Reads

Evaluating a New International Risk-Prediction Tool in IgA Nephropathy.

JAMA Intern Med 2019 Apr 13. Epub 2019 Apr 13.

Division of Nephrology, University of Toronto, Toronto, Ontario, Canada.

Importance: Although IgA nephropathy (IgAN) is the most common glomerulonephritis in the world, there is no validated tool to predict disease progression. This limits patient-specific risk stratification and treatment decisions, clinical trial recruitment, and biomarker validation.

Objective: To derive and externally validate a prediction model for disease progression in IgAN that can be applied at the time of kidney biopsy in multiple ethnic groups worldwide. Read More

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http://dx.doi.org/10.1001/jamainternmed.2019.0600DOI Listing
April 2019
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Demographic, medical, social-cognitive, and environmental correlates of meeting independent and combined physical activity guidelines in kidney cancer survivors.

Support Care Cancer 2019 Apr 12. Epub 2019 Apr 12.

Faculty of Kinesiology and Physical Education, University of Toronto, 55 Harbord Street, Toronto, ON, M5S 2W6, Canada.

Purpose: Guidelines for cancer survivors recommend both aerobic physical activity (PA) and strength training (ST). Few kidney cancer survivors (KCS) are meeting single-activity or combined guidelines; therefore, examining factors influencing PA participation is warranted. The purpose of this study is to examine demographic, medical, social-cognitive, and environmental correlates of meeting independent (i. Read More

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http://dx.doi.org/10.1007/s00520-019-04752-xDOI Listing
April 2019
2.364 Impact Factor

The incidence of pregnancy hypertension in India, Pakistan, Mozambique, and Nigeria: A prospective population-level analysis.

PLoS Med 2019 Apr 12;16(4):e1002783. Epub 2019 Apr 12.

School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.

Background: Most pregnancy hypertension estimates in less-developed countries are from cross-sectional hospital surveys and are considered overestimates. We estimated population-based rates by standardised methods in 27 intervention clusters of the Community-Level Interventions for Pre-eclampsia (CLIP) cluster randomised trials.

Methods And Findings: CLIP-eligible pregnant women identified in their homes or local primary health centres (2013-2017). Read More

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http://dx.doi.org/10.1371/journal.pmed.1002783DOI Listing
April 2019
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Trends in the Proportion of Female Speakers at Medical Conferences in the United States and in Canada, 2007 to 2017.

JAMA Netw Open 2019 Apr 5;2(4):e192103. Epub 2019 Apr 5.

Division of Endocrinology and Metabolism, Department of Medicine, University of Calgary, Calgary, Alberta, Canada.

Importance: Gender equity is a prominent issue in the medical profession. Representation of female physicians at academic meetings has been identified as an important component of gender equity; however, this topic has not been systematically assessed.

Objective: To determine the trend during the last decade in the proportion of speakers who were women at major academic medical conferences held in Canada and in the United States. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2019.2103DOI Listing

A novel gaze-supported multimodal human-computer interaction for ultrasound machines.

Int J Comput Assist Radiol Surg 2019 Apr 11. Epub 2019 Apr 11.

Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada.

Purpose: Conventional ultrasound (US) machines employ a physical control panel (PCP) as the primary user interface for machine control. This panel is adjacent to the main machine display that requires the operator's constant attention. The switch of attention to the control panel can lead to interruptions in the flow of the medical examination. Read More

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http://link.springer.com/10.1007/s11548-019-01964-8
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http://dx.doi.org/10.1007/s11548-019-01964-8DOI Listing
April 2019
2 Reads

Maternal proximity to extremely low frequency electromagnetic fields and risk of birth defects.

Eur J Epidemiol 2019 Apr 11. Epub 2019 Apr 11.

National Collaborating Centre for Environmental Health, British Columbia Centre for Disease Control, Vancouver, Canada.

Causes of birth defects are unclear, and the association with electromagnetic fields is inconclusive. We assessed the relationship between residential proximity to extremely low frequency electromagnetic fields from power grids and risk of birth defects. We analyzed a population-based sample of 2,164,246 infants born in Quebec, Canada between 1989 and 2016. Read More

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http://link.springer.com/10.1007/s10654-019-00518-1
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http://dx.doi.org/10.1007/s10654-019-00518-1DOI Listing
April 2019
2 Reads

Prognostic significance of hTERT (human telomerase reverse transcriptase) promoter region mutations C228T and C250T for overall survival in spinal chordomas.

Neuro Oncol 2019 Apr 12. Epub 2019 Apr 12.

Department of Neurosurgery, MD Anderson Cancer Center, The University of Texas, Houston, Texas.

Background: Spinal chordomas, a sub-type of primary spinal column malignancies (PSCM), are rare tumors with poor prognosis and limited understanding of the molecular drivers of neoplasia.

Methods: Study design was a retrospective review of prospectively collected data with cross-sectional survival. Archived paraffin embedded pathologic specimens were collected for 133 patients from 6 centers within Europe and North America between 1987 and 2012. Read More

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http://dx.doi.org/10.1093/neuonc/noz066DOI Listing

Effectiveness of Ledipasvir/Sofosbuvir and Sofosbuvir/Velpatasvir in People Who Inject Drugs and/or Those in Opioid Agonist Therapy.

Hepatol Commun 2019 Apr 10;3(4):478-492. Epub 2019 Jan 10.

British Columbia Centre for Disease Control Vancouver Canada.

We evaluated the effectiveness of ledipasvir/sofosbuvir (LDV/SOF) in treating hepatitis C virus (HCV) genotype 1 and SOF/velpatasvir (SOF/VEL) for all genotypes among people who inject drugs (PWID) and those not injecting drugs and who were on or off opioid agonist therapy (OAT). Study participants comprised a population-based cohort in British Columbia, Canada. The British Columbia Hepatitis Testers Cohort includes data on individuals tested for HCV from 1990 to 2016 that are integrated with medical visits, hospitalization, and prescription drug data. Read More

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http://doi.wiley.com/10.1002/hep4.1307
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http://dx.doi.org/10.1002/hep4.1307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442698PMC
April 2019
4 Reads

Maternal serum concentrations of perfluoroalkyl substances and birth size in British boys.

Int J Hyg Environ Health 2019 Apr 8. Epub 2019 Apr 8.

Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Rd NE, Atlanta, GA, 30322, United States; National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, Atlanta, GA, 30341, United States.

Per- and polyfluoroalkyl substances (PFAS) have been widely used in commercial and industrial manufacturing processes since the 1950s. Inverse associations between prenatal exposure to PFAS and birth size have been found in populations around the globe. This study examined the association of prenatal maternal serum concentrations of perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA) and birth size in British boys. Read More

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http://dx.doi.org/10.1016/j.ijheh.2019.03.008DOI Listing

Evaluation of ophthalmology clerkships across teaching sites at the University of British Columbia.

Can J Ophthalmol 2019 Apr 5;54(2):150-154. Epub 2018 Jun 5.

Department of Ophthalmology and Visual Sciences, Faculty of Medicine, University of British Columbia.

Objective: Clerkship at the University of British Columbia (UBC) Medical School encompasses a variety of models: traditional rotation-based clerkship; distributed rotation-based clerkship at sites across the province; and a longitudinal integrated community clerkship. The purpose of this study was to: (i) Evaluate the undergraduate ophthalmology clerkship experience at UBC to compare outcomes and experiences across the various sites and models; and (ii) Apply educational theories to evaluation outcomes in order to improve curriculum design for clerkship programs.

Design: Cross-sectional evaluation of the ophthalmology clerkship program at UBC. Read More

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http://dx.doi.org/10.1016/j.jcjo.2018.04.008DOI Listing

Silica nanoparticles trigger the vascular endothelial dysfunction and prethrombotic state via miR-451 directly regulating the IL6R signaling pathway.

Part Fibre Toxicol 2019 Apr 11;16(1):16. Epub 2019 Apr 11.

Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, 100069, People's Republic of China.

Background: Safety evaluation is a prerequisite for nanomaterials in a wide range of fields, including chemical industries, medicine or food sciences. Previously, we had demonstrated that SiNPs could trigger the thrombotic effects in vivo, but the underlying mechanisms remain unknown. This study was aimed to explore and verify the role of miR-451a on SiNPs-induced vascular endothelial dysfunction and pre-thrombotic state. Read More

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http://dx.doi.org/10.1186/s12989-019-0300-xDOI Listing

The aorta after coarctation repair - effects of calibre and curvature on arterial haemodynamics.

J Cardiovasc Magn Reson 2019 Apr 11;21(1):22. Epub 2019 Apr 11.

Centre for Translational Cardiovascular Imaging, Institute of Cardiovascular Science, University College London and Great Ormond Street Hospital for Children, London, WC1N 3JH, UK.

Background: Aortic shape has been proposed as an important determinant of adverse haemodynamics following coarctation repair. However, previous studies have not demonstrated a consistent relationship between shape and vascular load. In this study, 3D aortic shape was evaluated using principal component analysis (PCA), allowing investigation of the relationship between 3D shape and haemodynamics. Read More

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http://dx.doi.org/10.1186/s12968-019-0534-7DOI Listing

Improving life after stroke needs global efforts to implement evidence-based physical activity pathways.

Int J Stroke 2019 Apr 11:1747493019840930. Epub 2019 Apr 11.

13 Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

There is an urgent need to improve life after stroke across the world-especially in low-income countries-through methods that are effective, equitable and sustainable. This paper highlights physical activity (PA) as a prime candidate for implementation. PA reduces modifiable risk factors for first and recurrent stroke and improves function and activity during rehabilitation and following discharge. Read More

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http://dx.doi.org/10.1177/1747493019840930DOI Listing

Particle Depletion Does Not Remediate Acute Effects of Traffic-Related Air Pollution and Allergen: A Randomized, Double-Blinded Crossover Study.

Am J Respir Crit Care Med 2019 Apr 12. Epub 2019 Apr 12.

University of British Columbia, Medicine, Vancouver, British Columbia, Canada ;

Rationale: Diesel exhaust (DE), an established model of traffic-related air pollution, contributes significantly to the global burden of asthma and may augment the effects of allergen inhalation. Newer diesel particulate-filtering technologies may increase NO emissions, raising questions regarding their effectiveness in reducing harm from associated engine output.

Objectives: To assess the effects of diesel exhaust and allergen co-exposure on lung function, airway responsiveness, and circulating leukocytes, and determine whether diesel exhaust particle-depletion remediates these effects. Read More

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http://dx.doi.org/10.1164/rccm.201809-1657OCDOI Listing
April 2019
2 Reads

A 3D bioprinted hydrogel mesh loaded with all-trans retinoic acid for treatment of glioblastoma.

Eur J Pharmacol 2019 Apr 8. Epub 2019 Apr 8.

Laboratory for Innovations in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada; Center for Advanced Materials and Related Technologies (CAMTEC), University of Victoria, Victoria, BC V8P 5C2, Canada; Center for Biomedical Research, University of Victoria, Victoria, BC V8P 5C2, Canada. Electronic address:

Treatment of glioblastoma (GBM), as the most lethal type of brain tumor, still remains a major challenge despite the various therapeutic approaches developed over the recent decades. GBM is considered as one of the most therapy-resistant human tumors. Treatment with TMZ chemotherapy and radiotherapy in GBM patients has led to 30% of two-year survival rate (American Brain Tumor Association), representing a demanding field to develop more effective therapeutic strategies. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.04.007DOI Listing
April 2019
8 Reads
2.532 Impact Factor