163,163 results match your criteria British journal of hospital medicine London England : 2005[Journal]


Snare-tip soft coagulation is effective and efficient as a first-line modality for treating intraprocedural bleeding during Barrett's mucosectomy.

Endoscopy 2020 Jul 13. Epub 2020 Jul 13.

The University of Sydney Westmead Clinical School, Medicine, Westmead, Australia.

Background And Study Aims: Intraprocedural bleeding (IPB) during multi-band mucosectomy (MBM) for Barrett's neoplasia (BN) can obscure the endoscopic field. Current hemostatic devices may affect procedure continuity and technical success. Snare-tip soft coagulation (STSC) as a first-line therapy for primary hemostasis has not been studied in this setting. Read More

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http://dx.doi.org/10.1055/a-1218-6089DOI Listing

Nighttime aeration mode enhanced the microalgae-bacteria symbiosis (ABS) system stability and pollutants removal efficiencies.

Sci Total Environ 2020 Jun 30;743:140607. Epub 2020 Jun 30.

State Key Laboratory of Urban Water Resource and Environment (SKLUWRE), Harbin Institute of Technology, 73 Huanghe Road, Nangang District, Harbin 150090, PR China. Electronic address:

Utilizing external aeration to enhance the performance of microalgae-bacteria symbiosis (ABS) system has been extensively studied. However, inappropriate aeration damaged ABS system stability. A nighttime aeration mode (NA-ABS) in different aeration intensities (20, 50, 100 mL/min) was adopted to compare to continuous aeration microalgae-bacteria symbiosis (CA-ABS) mode and no-aerated mode on pollutants removal efficiencies and system stability. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2020.140607DOI Listing

Long-Term, Open-Label Extension Study of the Efficacy and Safety of Epicutaneous Immunotherapy for Peanut Allergy in Children: PEOPLE 3-Year Results.

J Allergy Clin Immunol 2020 Jul 10. Epub 2020 Jul 10.

DBV Technologies, Montrouge, France; Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Background: We previously reported the safety and efficacy of epicutaneous immunotherapy (EPIT™) for peanut allergy (250 μg, daily epicutaneous peanut protein; DBV712 250μg) in a 12-month randomized controlled study (PEPITES) of peanut-allergic children aged 4-11 years.

Objective: To assess interim safety and efficacy of an additional 2 years of EPIT from the ongoing (5-year treatment) open-label extension PEOPLE study.

Methods: Subjects who completed PEPITES were offered enrollment in PEOPLE. Read More

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http://dx.doi.org/10.1016/j.jaci.2020.06.028DOI Listing

The Static-99R Is Not Valid For Women: Predictive Validity in 739 Females Who Have Sexually Offended.

Sex Abuse 2020 Jul 13:1079063220940303. Epub 2020 Jul 13.

Simon Fraser University, Burnaby, British Columbia, Canada.

Although many instruments have been validated to assess risk of sexual recidivism among men, no similar tool exists for women who have sexually offended. As a result, some jurisdictions use male-based instruments to assess women despite the lack of validation research examining the predictive utility for this subgroup. This study examined the utility of the Static-99R in predicting sexual recidivism among women. Read More

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http://dx.doi.org/10.1177/1079063220940303DOI Listing

Occurrence, characterization, and ecological assessment of petroleum-related hydrocarbons in intertidal marine sediments of Burrard Inlet, Vancouver, British Columbia, Canada.

Mar Pollut Bull 2020 Aug 29;157:111304. Epub 2020 May 29.

Emergencies Science and Technology Section (ESTS), Environment & Climate Change Canada, Ottawa, ON, Canada.

Total petroleum hydrocarbons (TPH), n-alkanes, petroleum biomarkers, and polycyclic aromatic hydrocarbons (PAHs) were analyzed in the intertidal sediments of Burrard Inlet, Vancouver, British Columbia, Canada. Most of the sampling sites had low TPH (<40 μg/g). Only 10% of sampling sites, located nearby a harbour and densely populated areas, had relatively high TPH (<260 μg/g). Read More

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http://dx.doi.org/10.1016/j.marpolbul.2020.111304DOI Listing

Using Causal Diagrams to Improve the Design and Interpretation of Medical Research.

Chest 2020 Jul;158(1S):S21-S28

Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Causal directed acyclic graphs (cDAGs) have become popular tools for researchers to better examine biases related to causal questions. DAGs comprise a series of arrows connecting nodes that represent variables and in doing so can demonstrate the causal relation between different variables. cDAGs can provide researchers with a blueprint of the exposure and outcome relation and the other variables that play a role in that causal question. Read More

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http://dx.doi.org/10.1016/j.chest.2020.03.011DOI Listing

Conversion of Urine Protein-Creatinine Ratio or Urine Dipstick Protein to Urine Albumin-Creatinine Ratio for Use in Chronic Kidney Disease Screening and Prognosis: An Individual Participant-Based Meta-analysis.

Ann Intern Med 2020 Jul 14. Epub 2020 Jul 14.

University of Groningen, University Medical Center, Groningen, the Netherlands, and The George Institute for Global Health, Sydney, New South Wales, Australia (H.J.H.).

Background: Although measuring albuminuria is the preferred method for defining and staging chronic kidney disease (CKD), total urine protein or dipstick protein is often measured instead.

Objective: To develop equations for converting urine protein-creatinine ratio (PCR) and dipstick protein to urine albumin-creatinine ratio (ACR) and to test their diagnostic accuracy in CKD screening and staging.

Design: Individual participant-based meta-analysis. Read More

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http://dx.doi.org/10.7326/M20-0529DOI Listing

Examining the role of context in written sarcasm comprehension: Evidence from eye-tracking during reading.

J Exp Psychol Learn Mem Cogn 2020 Jul 13. Epub 2020 Jul 13.

School of Psychology.

This article addresses a current theoretical debate between modular and interactive accounts of sarcasm processing, by investigating the role of context (specifically, knowing that a character has been sarcastic before) in the comprehension of a sarcastic remark. An eye-tracking experiment was conducted in which participants were asked to read texts that introduced a character as being either sarcastic or not and ended in either a literal or an unfamiliar sarcastic remark. The results indicated that when the character was previously literal, a subsequent sarcastic remark was more difficult to process than its literal counterpart. Read More

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http://dx.doi.org/10.1037/xlm0000910DOI Listing

FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity.

J Exp Med 2020 Oct;217(10)

Division of Gastroenterology, Hepatology, and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

IgG immune complexes (ICs) promote autoimmunity through binding fragment crystallizable (Fc) γ-receptors (FcγRs). Of these, the highly prevalent FcγRIIa (CD32a) histidine (H)-131 variant (CD32aH) is strongly linked to human autoimmune diseases through unclear mechanisms. We show that, relative to the CD32a arginine (R)-131 (CD32aR) variant, CD32aH more avidly bound human (h) IgG1 IC and formed a ternary complex with the neonatal Fc receptor (FcRn) under acidic conditions. Read More

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http://dx.doi.org/10.1084/jem.20200359DOI Listing
October 2020

COVID-19 Recommendations From Ophthalmic and Plastic Reconstructive Surgery Societies Worldwide.

Ophthalmic Plast Reconstr Surg 2020 Jul/Aug;36(4):334-345

Department of Ophthalmology, Stanford University School of Medicine, Stanford, California, U.S.A.

Purpose: The COVID-19 pandemic has brought unprecedented challenges for oculoplastic surgeons worldwide, in terms of care delivery, medical equipment and at-risk patient management. To date, there are no centralized or compiled international COVID-19 guidelines for oculoplastic surgeons.

Methods: We examined COVID-19 guidelines published by oculoplastic societies worldwide. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001776DOI Listing

The Effect of Unilateral Vestibular Loss on Standing Balance During Postural Threat.

Otol Neurotol 2020 Aug;41(7):e945-e951

School of Kinesiology.

Objective: Vestibular deficit patients have an increased fall risk and fear of falling. Postural threat, known to increase balance-related fear and anxiety, influences vestibular gains during quiet standing in young healthy adults. The current study examined whether there is a similar relationship for peripheral unilateral vestibular loss (UVL) patients in comparison to age-matched healthy controls (HC). Read More

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http://dx.doi.org/10.1097/MAO.0000000000002485DOI Listing

Consistent Morning Exercise May Be Beneficial For Individuals with Obesity.

Exerc Sport Sci Rev 2020 Jul 8. Epub 2020 Jul 8.

Weight Control and Diabetes Research Center, The Miriam Hospital/Brown Alpert Medical School, Providence, Rhode Island, USA.

This review explores the hypothesis that a consistent exercise time, especially consistent morning exercise, improves exercise adherence and weight management for individuals with overweight or obesity. We discuss data supporting this premise, identify limitations of current research, and outline directions for future research on exercise timing to more robustly evaluate our thesis. Read More

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http://dx.doi.org/10.1249/JES.0000000000000226DOI Listing

The Efficacy and Safety of Piribedil Relative to Pramipexole for the Treatment of Early Parkinson Disease: A Systematic Literature Review and Network Meta-Analysis.

Clin Neuropharmacol 2020 Jul/Aug;43(4):100-106

Doctor Evidence, Santa Monica, CA.

Objectives: Patients with early Parkinson disease (PD) frequently defer initiation of levodopa treatment to minimize long-term complications. Nonergoline dopamine agonists, such as pramipexole and piribedil, are frequent first-line therapies for early PD patients, yet limited head-to-head randomized controlled trial (RCT) evidence exists for dopamine agonists in this population. We therefore conducted a systematic literature review and network meta-analysis. Read More

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http://dx.doi.org/10.1097/WNF.0000000000000400DOI Listing

Cost-Effectiveness of Thoracotomy Approach for the Implantation of a Centrifugal Left Ventricular Assist Device.

ASAIO J 2020 Jul 1. Epub 2020 Jul 1.

Department of Cardiothoracic Surgery, Advent Health Transplant Institute, Orlando, FL.

This study reports the first analysis regarding cost-effectiveness of left ventricular assist device (LVAD) implantation via thoracotomy. Cost-effectiveness of LVADs implanted via the traditional surgical approach of sternotomy has been improved through the years because of technological advances, along with understanding the importance of patient selection and postimplant management have on positively affecting outcomes. Given the positive clinical outcomes of the thoracotomy approach, we seek to study the cost-effectiveness of a centrifugal LVAD via this less invasive approach. Read More

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http://dx.doi.org/10.1097/MAT.0000000000001209DOI Listing

An evaluation of renin-angiotensin system markers in youth with type 2 diabetes and associations with renal outcomes.

Pediatr Diabetes 2020 Jul 13. Epub 2020 Jul 13.

Division of Nephrology, Department of Medicine, Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa.

Aims/hypothesis: Youth with type 2 diabetes (T2D) have high rates of obesity, hypertension and suboptimal glycemic control. We hypothesized that RAS activation is present in youth with type 2 diabetes and associated with poor glycemic control and renal outcomes.

Methods: Cross-sectional analysis of 183 youth with T2D and 100 controls from the Improving renal Complications in Adolescents with type 2 diabetes through REsearch (iCARE) cohort. Read More

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http://dx.doi.org/10.1111/pedi.13081DOI Listing

Use of a novel prescribing approach for the treatment of opioid use disorder: Buprenorphine/naloxone micro-dosing - a case series.

Drug Alcohol Rev 2020 Jul;39(5):588-594

British Columbia Centre on Substance Use, Vancouver, Canada.

Introduction And Aims: Buprenorphine/naloxone is an evidence-based treatment for opioid use disorder, but an identified limitation is the period of required opioid abstinence prior to induction on the medication. 'Micro-dosing', or using incrementally increasing doses of buprenorphine/naloxone over time, may be a way to overcome this challenge as it can be done in parallel with the ongoing use of other opioids (either illicit or prescribed).

Design And Methods: A retrospective case series (January to December 2018) was completed of seven participants who underwent buprenorphine/naloxone induction using micro-dosing at two outpatient addiction clinics in Vancouver, Canada. Read More

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http://dx.doi.org/10.1111/dar.13113DOI Listing

Dichloroacetate (DCA) reveals the presence of metabolic inertia at the start of exercise in rainbow trout (Oncorhynchus mykiss, Walbaum 1792).

J Fish Biol 2020 Jul 13. Epub 2020 Jul 13.

Department of Medicine, McMaster University, Hamilton, ON, Canada.

A lag in the increase of oxygen consumption (MO ) occurs at the start of sustainable exercise in trout. Waterborne dichloroacetate (DCA, 0.58 and 3. Read More

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http://dx.doi.org/10.1111/jfb.14461DOI Listing

Identification of conserved evolutionary trajectories in tumors.

Bioinformatics 2020 Jul;36(Supplement_1):i427-i435

Cancer Data Science Lab., National Cancer Institute, NIH, Bethesda, MD, USA.

Motivation: As multi-region, time-series and single-cell sequencing data become more widely available; it is becoming clear that certain tumors share evolutionary characteristics with others. In the last few years, several computational methods have been developed with the goal of inferring the subclonal composition and evolutionary history of tumors from tumor biopsy sequencing data. However, the phylogenetic trees that they report differ significantly between tumors (even those with similar characteristics). Read More

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http://dx.doi.org/10.1093/bioinformatics/btaa453DOI Listing

AITL: Adversarial Inductive Transfer Learning with input and output space adaptation for pharmacogenomics.

Bioinformatics 2020 Jul;36(Supplement_1):i380-i388

School of Computing Science, Simon Fraser University, Burnaby, BC, Canada.

Motivation: The goal of pharmacogenomics is to predict drug response in patients using their single- or multi-omics data. A major challenge is that clinical data (i.e. Read More

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http://dx.doi.org/10.1093/bioinformatics/btaa442DOI Listing

Methylation of cysteinyl leukotriene receptor 1 genes associates with lung function in asthmatics exposed to traffic-related air pollution.

Epigenetics 2020 Jul 12:1-9. Epub 2020 Jul 12.

Department of Medicine, P: 604-875-4729, University of British Columbia , Vancouver, BC, Canada.

Air pollution is associated with early declines in lung function and increased levels of asthma-related cysteinyl leukotrienes (CysLT) but a biological pathway linking this rapid response has not been delineated. In this randomized controlled diesel exhaust (DE) challenge study of 16 adult asthmatics, increased exposure-attributable urinary leukotriene E4 (uLTE4, a biomarker of cysteinyl leukotriene production) was correlated (p = 0.04) with declines in forced expiratory volume in 1-second (FEV) within 6 hours of exposure. Read More

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http://dx.doi.org/10.1080/15592294.2020.1790802DOI Listing

TDP-43 pathology in primary lateral sclerosis.

Amyotroph Lateral Scler Frontotemporal Degener 2020 Jul 11:1-7. Epub 2020 Jul 11.

Division of Neurology, University of British Columbia, Vancouver, BC, Canada.

Primary lateral sclerosis (PLS) is a controversial form of motor neuron disease (MND), with uncertainty whether it represents a distinct clinico-pathological entity or is simply a variant of classical amyotrophic lateral sclerosis (ALS). Neuropathological studies provide an opportunity to investigate these issues; however, there have been very few published descriptions of postmortem findings in clinically defined PLS, using modern techniques. Here, we report the neuropathological features of seven cases of PLS with age at onset ranging from 47 to 73 years and disease duration from 3. Read More

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http://dx.doi.org/10.1080/21678421.2020.1790607DOI Listing

Quality of life and caregiver burden in familial frontotemporal lobar degeneration: Analyses of symptomatic and asymptomatic individuals within the LEFFTDS cohort.

Alzheimers Dement 2020 Jul 13. Epub 2020 Jul 13.

Mayo Clinic, Rochester, Minnesota, USA.

Objective: The Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects evaluates familial frontotemporal lobar degeneration (FTLD) kindreds with MAPT, GRN, or C9orf72 mutations. Objectives were to examine whether health-related quality of life (HRQoL) correlates with clinical symptoms and caregiver burden, and whether self-rated and informant-rated HRQoL would correlate with each other.

Methods: Individuals were classified using the Clinical Dementia Rating (CDR ) Scale plus National Alzheimer's Coordinating Center (NACC) FTLD. Read More

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http://dx.doi.org/10.1002/alz.12095DOI Listing

Achieving the "trifecta" with open versus minimally invasive partial nephrectomy.

World J Urol 2020 Jul 12. Epub 2020 Jul 12.

University of British Columbia, Level 6, 2775 Laurel Street, Vancouver, BC, V5Z 1M9, Canada.

Introduction: The "trifecta" is a summary measure of outcome after partial nephrectomy (PN) that encompasses three parameters: negative surgical margin, ≤ 10% decrease in post-operative estimated glomerular filtration rate (eGFR) and absence of urological complications. We assessed trifecta rates in patients undergoing open (OPN), laparoscopic (LPN), and robotic PN (RPN) for a clinical T1 renal mass (≤ 7 cm).

Methods: Clinical and pathologic parameters were extracted from the prospectively maintained Canadian Kidney Cancer Information System for patients treated between January 2011 and October 2018. Read More

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http://dx.doi.org/10.1007/s00345-020-03349-yDOI Listing

The Orthopaedic Management of Human Disorganization Syndrome.

J Am Acad Orthop Surg Glob Res Rev 2020 Jun 15;4(6). Epub 2020 Jun 15.

Division of Orthopedic Surgery, Children's Hospital of Eastern Ontario, Ottawa, ON (Dr. Smit); Faculty of Medicine, University of British Columbia, Vancouver, BC (Ms. So); and Department of Orthopaedics, BC Children's Hospital, Vancouver, BC (Dr. Schaeffer, Dr. Armstrong, Dr. Verchere, and Dr. Mulpuri).

Human disorganization syndrome (HDS) is an extremely rare congenital syndrome characterized by a seemingly random distribution of multiple developmental anomalies involving all three germinal layers.

Case Report: We report a rare case of a female child whose congenital anomalies are consistent with HDS. The orthopaedic features of this patient include a popliteus pterygium with an associated flexion contracture secondary to an elongated biceps femoris tendon that attached to the gastrocnemius-soleus muscle complex, two finger-like appendages, a tethered cord, a lipomeningomyelocele at the level of L5, and a leglength discrepancy. Read More

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http://dx.doi.org/10.5435/JAAOSGlobal-D-20-00059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322784PMC

Exploring Knowledge and Perspectives of South Asian Children and Their Parents Regarding Healthy Cardiovascular Behaviors: A Qualitative Analysis.

Glob Pediatr Health 2020 1;7:2333794X20924505. Epub 2020 Jul 1.

Simon Fraser University, Burnaby, British Columbia, Canada.

South Asian children and parents have been shown to have a higher risk for cardiovascular disease (CVD) relative to white individuals. To design interventions aimed at addressing the comparatively higher burden in South Asians, a better understanding of attitudes and perspectives regarding CVD-associated behaviors is needed. As a result, we sought to understand knowledge about CVD risk in both children and parents, and attitudes toward physical activity and diet in both the children and parents, including potential cultural influences. Read More

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http://dx.doi.org/10.1177/2333794X20924505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331759PMC

Short-term outcomes of pediatric multiple sclerosis patients treated with alemtuzumab at a Canadian University multiple sclerosis clinic.

Mult Scler J Exp Transl Clin 2020 Apr-Jun;6(2):2055217320926613. Epub 2020 Jul 1.

Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, Canada.

There is a lack of literature documenting the use of alemtuzumab in pediatric multiple sclerosis (MS) patients. Here we describe a 16-year-old and a 17-year-old patient receiving alemtuzumab and being followed for 37 months and 20 months, respectively. Both patients experienced a 1. Read More

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http://dx.doi.org/10.1177/2055217320926613DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333501PMC

Nutritional management of a kitten with thermal burns and septicaemia.

JFMS Open Rep 2020 Jan-Jun;6(1):2055116920930486. Epub 2020 Jun 29.

Department of Clinical Science and Services, The Royal Veterinary College, North Mymms, Hatfield, UK.

Case Summary: A 3-month-old entire female British Shorthair cat presented for further management of thermal burns after falling into a bath of scalding water. On presentation to the primary care clinician the kitten was obtunded, markedly painful and relatively bradycardic, consistent with a state of shock. The haircoat was wet, with erythematous skin and sloughing from the digital pads and anal mucosa. Read More

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http://dx.doi.org/10.1177/2055116920930486DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328498PMC

Effectiveness of Latent TB Screening and Treatment in People Initiating Dialysis in British Columbia, Canada.

Can J Kidney Health Dis 2020 2;7:2054358120937104. Epub 2020 Jul 2.

British Columbia Centre for Disease Control, Vancouver, Canada.

Background: People undergoing chronic dialysis are at an increased risk of active tuberculosis (TB). In 2012, the Canadian province of British Columbia began systematically screening people initiating dialysis for latent TB using interferon-gamma release assay (IGRA), and treating when appropriate.

Objective: The objective of this study was to compare active TB rate in people who initiated dialysis and were screened using an IGRA compared with those not screened during the same period. Read More

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http://dx.doi.org/10.1177/2054358120937104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333484PMC

Computed tomography calcium scoring association and reclassification of clinical cardiovascular risk in asymptomatic Mexican patients.

SAGE Open Med 2020 2;8:2050312120938233. Epub 2020 Jul 2.

Department of Radiology and Molecular Imaging, Centro Médico ABC (The American British Cowdray Medical Center), Mexico City, Mexico.

Objectives: To establish tailored preventive treatment, we studied the ability of coronary artery calcium scoring to reclassify patients with intermediate cardiovascular risk and its association with additional risk factors in our Mexican preventive care center.

Materials And Methods: In this retrospective cohort study, we analyzed 520 asymptomatic patients from a Mexican primary prevention population between 2014 and 2018. Coronary artery calcium scoring, laboratory results, and anthropometric measurements (abdominal circumference and body mass index) were assessed. Read More

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http://dx.doi.org/10.1177/2050312120938233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7333485PMC

An Efficient and Footprint-Free Protocol for the Transdifferentiation of Hepatocytes Into Insulin-Producing Cells With IVT mRNAs.

Front Genet 2020 5;11:575. Epub 2020 Jun 5.

Hubei Key Laboratory of Embryonic Stem Cell Research, Taihe Hospital, Hubei University of Medicine, Shiyan, China.

Background: Direct transdifferentiation of adult somatic cells into insulin-producing cells (IPCs) is a promising approach for cell-based therapies for type 1 diabetes mellitus. Liver cells are an ideal source for generating IPCs because they have regenerative ability and a developmental process similar to that of the pancreas. Pancreas versus liver fate is regulated by TALE homeoprotein (TGIF2) during development. Read More

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http://dx.doi.org/10.3389/fgene.2020.00575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325981PMC

Resistance Exercise in a Hot Environment Alters Serum Markers in Untrained Males.

Front Physiol 2020 23;11:597. Epub 2020 Jun 23.

Université de Rennes, M2S (Laboratoire Mouvement, Sport, Santé) - EA 1274, Rennes, France.

We examined the effects of moderate resistance exercise (RE) on serum cortisol, testosterone, extracellular heat shock protein (HSP70), and interleukin (IL)-6 and IL-15 concentrations in untrained males in a hot environment. Ten untrained young males (26 ± 3 years; 75.8 ± 6 kg; 177. Read More

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http://dx.doi.org/10.3389/fphys.2020.00597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324790PMC

Twenty years of pyodermas: How antimicrobial resistance has changed the way I practice.

Authors:
Kinga Gortel

Can Vet J 2020 Jul;61(7):781-784

President of the Executive Committee of the Canadian Academy of Veterinary Dermatology, Westbank Animal Care Hospital, West Kelowna, British Columbia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313356PMC

Descriptive epidemiology of companion animal dermatophytosis in a Canadian Pacific Northwest animal shelter system.

Can Vet J 2020 Jul;61(7):763-770

British Columbia Society for the Prevention of Cruelty to Animals Ringgold standard institution, Vancouver, British Columbia (Gordon, Idle); Cornell University Ringgold standard institution - Maddie's Shelter Medicine Program, Cornell University College of Veterinary Medicine, Ithaca, New York, USA (DeTar).

This study investigated the frequency of false positive dermatophyte cultures, dermatophyte prevalence, and dermatophytosis risk factors in an animal sheltering system in British Columbia. Records for 80 471 incoming shelter animals over 3.5 years were accessed retrospectively. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296869PMC

Long-Term Physical Activity Levels After the End of a Structured Exercise Intervention in Adults With Type 2 Diabetes and Prediabetes: A Systematic Review.

Can J Diabetes 2020 Apr 8. Epub 2020 Apr 8.

Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Department of Cardiac Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. Electronic address:

Objectives: Randomized, controlled trials have shown that exercise interventions reduce the incidence of type 2 diabetes in people with impaired glucose tolerance, and improve glycemic control, body composition and cardiorespiratory fitness in people with type 2 diabetes. We undertook the present systematic review to determine the extent to which participants in structured exercise trials continue to be physically active after the end of the interventions.

Methods: We systematically searched MEDLINE, EMBASE, CINAHL, SPORTDiscus and Cochrane Central Register of Controlled Trials for randomized, controlled trials that reported objective or self-reported physical activity levels in people with type 2 diabetes or prediabetes a minimum of 3 months after the end of a structured exercise intervention. Read More

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http://dx.doi.org/10.1016/j.jcjd.2020.03.012DOI Listing

A comparative assessment of the performance of a state-of-the art small footprint dedicated cardiovascular CT scanner.

J Cardiovasc Comput Tomogr 2020 Jun 26. Epub 2020 Jun 26.

Department of Radiology, St Paul's Hospital, Vancouver, British Columbia, Canada. Electronic address:

Introduction: With increasing adoption of CT coronary angiography (CTA) there is increasing demand for cost-effective, small footprint, dedicated cardiac scanners. We compared a state-of-the-art, small footprint dedicated cardiac scanner (DCCT) to a standard multidetector scanner (MDCT).

Methods: The study was a retrospective unblinded single centre study. Read More

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http://dx.doi.org/10.1016/j.jcct.2020.04.002DOI Listing

Developing Consensus-Based Outcome Domains for Trials in Children and Adolescents With CKD: An International Delphi Survey.

Am J Kidney Dis 2020 Jul 9. Epub 2020 Jul 9.

Sydney School of Public Health, The University of Sydney, NSW, Australia; Centre for Kidney Research, The Children's Hospital at Westmead, Westmead, NSW, Australia. Electronic address:

Rationale & Objective: The inconsistency in outcomes reported and lack of patient-reported outcomes across trials in children with chronic kidney disease (CKD) limits shared decision making. As part of the Standardized Outcomes in Nephrology (SONG)-Kids initiative, we aimed to generate a consensus-based prioritized list of critically important outcomes to be reported in all trials in children with CKD.

Study Design: An online 2-round Delphi survey in English, French, and Hindi languages. Read More

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http://dx.doi.org/10.1053/j.ajkd.2020.03.014DOI Listing

Risk Prediction Tool for Assessing the Probability of Death or Myocardial Infarction in Patients With Stable Coronary Artery Disease.

Am J Cardiol 2020 Jun 8. Epub 2020 Jun 8.

MedStar Washington Hospital Center, Washington, D.C.

Several risk scores in acute coronary syndromes are available, but few models exist for stable coronary artery disease to guide decision-making and prognosis. A multivariate model was developed using 23 baseline candidate variables from the Clinical Outcomes Utilizing Revascularization and Aggressive Drug Therapy EvaluationTrial (n = 2,287 patients). Discrimination of the model was evaluated by the concordance c-index. Read More

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http://dx.doi.org/10.1016/j.amjcard.2020.05.046DOI Listing

A National Evaluation of Emergency Cardiac Surgery After Percutaneous Coronary Intervention and Postsurgical Patient Outcomes.

Am J Cardiol 2020 Jun 7. Epub 2020 Jun 7.

Keele Cardiovascular Research Group, Keele University, Stoke-on-Trent, UK; Department of Cardiology, Royal Stoke University Hospital, Stoke-on-Trent, UK. Electronic address:

There is limited national data regarding emergency cardiac surgery for complications sustained after percutaneous coronary intervention (PCI). This study aimed to examine emergency cardiac surgery after PCI in England and Wales and postsurgical patient outcomes. We analyzed patients in the British Cardiovascular Intervention Society database who underwent PCI between 2007 and 2014 and compared characteristics and outcomes for patients with and without emergency cardiac surgery. Read More

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http://dx.doi.org/10.1016/j.amjcard.2020.05.041DOI Listing

Treatment Optimization in Multiple Sclerosis: Canadian MS Working Group Recommendations.

Can J Neurol Sci 2020 Jul 6;47(4):437-455. Epub 2020 Apr 6.

The Hospital for Sick Children, Toronto, Ontario, Canada.

The Canadian Multiple Sclerosis Working Group has updated its treatment optimization recommendations (TORs) on the optimal use of disease-modifying therapies for patients with all forms of multiple sclerosis (MS). Recommendations provide guidance on initiating effective treatment early in the course of disease, monitoring response to therapy, and modifying or switching therapies to optimize disease control. The current TORs also address the treatment of pediatric MS, progressive MS and the identification and treatment of aggressive forms of the disease. Read More

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http://dx.doi.org/10.1017/cjn.2020.66DOI Listing

Various factors affect lipopolysaccharide sensitization in cell cultures.

Biotechniques 2020 Jul 13. Epub 2020 Jul 13.

Centre for Heart Lung Innovation, University of British Columbia, St. Paul's Hospital, Vancouver, BC, Canada.

Commercially available lipopolysaccharide (LPS) is commonly used in research. Although protocols for its use are well established, we experienced a loss of LPS responsiveness in our cell cultures despite no obvious experimental changes. Our cell lines were stimulated with LPS and the media quantified for LPS responsiveness via an IL-8 ELISA. Read More

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http://dx.doi.org/10.2144/btn-2020-0043DOI Listing

The effects of magnesium supplementation on obesity measures in adults: a systematic review and dose-response meta-analysis of randomized controlled trials.

Crit Rev Food Sci Nutr 2020 Jul 11:1-17. Epub 2020 Jul 11.

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, IR.

Previous studies reported inconsistent findings regarding the effects of magnesium supplementation on obesity measures. This study was done to quantify the effect of magnesium supplementation on body weight, Body Mass Index (BMI), Waist Circumference (WC), Body Fat (BF) percentage and Waist to Hip Ratio (WHR). Four online databases (Scopus, PubMed, Google Scholar and Cochrane library) were searched until March 2020 using relevant keywords. Read More

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http://dx.doi.org/10.1080/10408398.2020.1790498DOI Listing

NLRP3 inflammasome as a novel therapeutic target for Alzheimer's disease.

Signal Transduct Target Ther 2020 Apr 1;5(1):37. Epub 2020 Apr 1.

Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.

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http://dx.doi.org/10.1038/s41392-020-0145-7DOI Listing

Use of Bisphosphonates and Other Bone Supportive Agents in the Management of Prostate Cancer - A UK Perspective.

Int J Clin Pract 2020 Jul 12:e13611. Epub 2020 Jul 12.

Queen's University Belfast, The Northern Ireland Cancer Centre, Belfast, Northern Ireland, UK.

Aim: To explore the practice and views of uro-oncologists in the UK regarding their use of bone supportive agents in patients with prostate cancer.

Methods: An expert-devised online questionnaire was completed by members of the British Uro-oncology Group (BUG).

Results: Of 160 uro-oncologists invited, 81 completed the questionnaire. Read More

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http://dx.doi.org/10.1111/ijcp.13611DOI Listing

Classification of sleep-related sudden unexpected death in infancy: a national survey.

Acta Paediatr 2020 Jul 12. Epub 2020 Jul 12.

Warwick Medical School, Coventry, CV4 7AL, UK.

Aim: To identify how British Child Death Overview Panels (CDOP) and paediatric pathologists classify cause of death for sleep-related Sudden Unexpected Death in Infancy (SUDI). To determine compliance with national requirements for SUDI investigation.

Methods: Electronic survey of CDOPs and pathologists using three vignettes of SUDI cases illustrating: accidental asphyxia, typical Sudden Infant Death Syndrome (SIDS) and SIDS with co-sleeping. Read More

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http://dx.doi.org/10.1111/apa.15472DOI Listing

Incorporation of extracorporeal photopheresis into a reduced intensity conditioning regimen in myelodysplastic syndrome and aggressive lymphoma: results from ECOG 1402 and 1902.

Transfusion 2020 Jul 12. Epub 2020 Jul 12.

Genentech Inc, San Francisco, California.

Background: Extracorporeal photopheresis (ECP) is an immunomodulatory cellular therapy which has been shown to induce a tolerogenic state in patients with acute and chronic graft-vs-host disease. ECOG-ACRIN explored the activity of ECP as a part of a reduced intensity conditioning regimen in two multicenter trials in patients with MDS (E1902) and lymphomas (E1402). While both studies closed before completing accrual, we report results in 23 patients (17 MDS and 6 lymphoma). Read More

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http://dx.doi.org/10.1111/trf.15798DOI Listing

Filamentous nestin and nonmuscle myosin IIB are associated with a migratory phenotype in neonatal rat cardiomyocytes.

J Cell Physiol 2020 Jul 11. Epub 2020 Jul 11.

Research Center, Montreal Heart Institute, Université de Montréal, Montréal, Québec, Canada.

Cardiomyocyte migration represents a requisite event of cardiogenesis and the regenerative response of the injured adult zebrafish and neonatal rodent heart. The present study tested the hypothesis that the appearance of the intermediate filament protein nestin in neonatal rat ventricular cardiomyocytes (NNVMs) was associated in part with the acquisition of a migratory phenotype. The cotreatment of NNVMs with phorbol 12,13-dibutyrate (PDBu) and the p38α/β mitogen-activated protein kinase inhibitor SB203580 led to the de novo synthesis of nestin. Read More

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http://dx.doi.org/10.1002/jcp.29934DOI Listing

Correction to: A Mathematical Model for the Kinetics of the MalFGK Maltose Transporter.

Bull Math Biol 2020 Jul 11;82(7):92. Epub 2020 Jul 11.

Department of Mathematics, University of British Columbia, Vancouver, Canada.

The original version of this article unfortunately contained a mistake. The co-author Dr. Franck Duong Van Hoa first name and last name were misinterpreted in the original publication. Read More

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http://dx.doi.org/10.1007/s11538-020-00772-5DOI Listing

Mortality, causes of death and influence of medication use in patients with systemic lupus erythematosus vs matched controls.

Rheumatology (Oxford) 2020 Jul 12. Epub 2020 Jul 12.

Division of Pharmacoepidemiology & Clinical Pharmacology, Utrecht University, Utrecht.

Objectives: We wanted to estimate the magnitude of the risk from all-cause, cause-specific and sex-specific mortality in patients with SLE and relative risks compared with matched controls and to evaluate the influence of exposure to medication on risk of mortality in SLE.

Methods: We conducted a population-based cohort study using the Clinical Practice Research Datalink, Hospital Episode Statistics and national death certificates (from 1987 to 2012). Each SLE patient (n = 4343) was matched with up to six controls (n = 21 780) by age and sex. Read More

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http://dx.doi.org/10.1093/rheumatology/keaa267DOI Listing

Development and validation of the Barriers to Physical Activity and Sport Questionnaire for lesbian, gay, bisexual, transgender and queer/questioning persons.

Public Health 2020 Jul 9;185:202-208. Epub 2020 Jul 9.

Departament d'Educació Física i Esportiva, Facultat de Ciències de l'Activitat Física i l'Esport, Universitat de València, Valencia, 46010 Spain. Electronic address:

Objective: The objective of the study was to develop the Barriers to Physical Activity and Sport Questionnaire for lesbian, gay, bisexual, transgender and queer/questioning (BPASQ-LGBTQ+ [encompassing all spectrums of sexuality and gender]) persons (BPASQ-LGBT), which measures barriers using a socio-ecological model, and to validate it through exploratory and confirmatory factor analysis.

Study Design: Validation study.

Methods: First, content validity was achieved by (a) developing a bank of items, (b) discussing the adequacy of the items in a committee of experts and classifying the selected ones under three socio-ecological levels (intrapersonal, interpersonal, environmental) and (c) refining wording and relevance of the items after a pilot test. Read More

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http://dx.doi.org/10.1016/j.puhe.2020.05.020DOI Listing

A potential role for hyperpolarization-activated cyclic nucleotide-gated sodium/potassium channels (HCNs) in teleost acid-base and ammonia regulation.

Comp Biochem Physiol B Biochem Mol Biol 2020 Jul 9:110469. Epub 2020 Jul 9.

University of British Columbia, Department of Zoology, 4200 - 6270 University Blvd., Vancouver, BC V6T 1Z4, Canada.

Increasing evidence suggests the involvement of hyperpolarization-activated cyclic nucleotide-gated sodium/potassium channels (HCNs) not only in cardiac and neural function, but also in more general physiological processes including acid-base and ammonia regulation. We have identified four different HCN paralogs/isoforms in the goldfish Carassius auratus (CaHCN1, CaHCN2b, CaHCN4a and CaHCN4b) as likely candidates to contribute to renal, branchial and intestinal acid-base and ammonia regulation in this teleost. Quantitative real-time PCR showed not only high mRNA abundance of all isoforms in heart and brain, but also detectable levels (particularly of CaHCN2b and CaHCN4b) in non-excitable tissues, including gills and kidneys. Read More

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http://dx.doi.org/10.1016/j.cbpb.2020.110469DOI Listing