145,658 results match your criteria British journal of hospital medicine London England : 2005[Journal]


Endothelial dysfunction in pregnancy metabolic disorders.

Biochim Biophys Acta Mol Basis Dis 2019 Feb 19. Epub 2019 Feb 19.

Departamento de Ciencias Biologicas, Facultad de Ciencias de la Vida, Universidad Andres Bello, 8370146 Santiago, Chile; Millennium Institute on Immunology and Immunotherapy, 8331150 Santiago, Chile. Electronic address:

In recent years, the vascular endothelium has gained attention as a key player in the initiation and development of pregnancy disorders. Endothelium acts as an endocrine organ that preserves the homeostatic balance by responding to changes in metabolic status. However, in metabolic disorders, endothelial cells adopt a dysfunctional function, losing their normal responsiveness. Read More

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http://dx.doi.org/10.1016/j.bbadis.2019.02.009DOI Listing
February 2019

An update on the controversy around offering oral immunotherapy to peanut-allergic children outside of research.

Ann Allergy Asthma Immunol 2019 Feb 19. Epub 2019 Feb 19.

Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, University of British Columbia, BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.anai.2019.02.011DOI Listing
February 2019

Integrated structural variation and point mutation signatures in cancer genomes using correlated topic models.

PLoS Comput Biol 2019 Feb 22;15(2):e1006799. Epub 2019 Feb 22.

Department of Epidemiology & Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America.

Mutation signatures in cancer genomes reflect endogenous and exogenous mutational processes, offering insights into tumour etiology, features for prognostic and biologic stratification and vulnerabilities to be exploited therapeutically. We present a novel machine learning formalism for improved signature inference, based on multi-modal correlated topic models (MMCTM) which can at once infer signatures from both single nucleotide and structural variation counts derived from cancer genome sequencing data. We exemplify the utility of our approach on two hormone driven, DNA repair deficient cancers: breast and ovary (n = 755 samples total). Read More

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http://dx.doi.org/10.1371/journal.pcbi.1006799DOI Listing
February 2019

RESEARCH IN NUTRITIONAL SUPPLEMENTS AND NUTRACEUTICALS FOR HEALTH, PHYSICAL ACTIVITY AND PERFORMANCE: MOVING FORWARD.

Appl Physiol Nutr Metab 2019 Feb 22. Epub 2019 Feb 22.

Canadian Sport Institute Pacific , Victoria, British Columbia, Canada ;

This Horizons is part of a series which identifies key, forward-thinking research questions and challenges that need to be addressed. Specifically, this Horizons paper discusses research in nutritional supplements and nutraceuticals for health, physical activity and performance, and is the product of a discussion by an expert panel that took place in January 2018 prior to the Canadian Nutrition Society Thematic Conference "Advances in Sport Nutrition from Daily Living to High Performance Sport". The objective of this Horizons was to identify core considerations for future studies for this research area, and how scientists can be leaders in the field to ensure the best quality science is available for decision makers. Read More

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http://dx.doi.org/10.1139/apnm-2018-0781DOI Listing
February 2019

Non-Invasive Imaging Biomarker Identifies Small Airway Damage in Severe COPD.

Am J Respir Crit Care Med 2019 Feb 22. Epub 2019 Feb 22.

University of Michigan, Pulmonary & Critical Care, Ann Arbor, Michigan, United States ;

Rationale: Evidence suggests damage to small airways is a key pathologic lesion in chronic obstructive pulmonary disease (COPD). Computed Tomography (CT) densitometry has been demonstrated to identify emphysema, but no such studies have been performed linking an imaging metric to small airway abnormality.

Objectives: To correlate ex vivo Parametric Response Mapping (PRM) analysis to in vivo lung tissue measurements of patients with severe COPD treated by lung transplantation and controls. Read More

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http://dx.doi.org/10.1164/rccm.201811-2083OCDOI Listing
February 2019
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Effect of Epicutaneous Immunotherapy vs Placebo on Reaction to Peanut Protein Ingestion Among Children With Peanut Allergy: The PEPITES Randomized Clinical Trial.

JAMA 2019 Feb 22. Epub 2019 Feb 22.

Massachusetts General Hospital, Boston.

Importance: There are currently no approved treatments for peanut allergy.

Objective: To assess the efficacy and adverse events of epicutaneous immunotherapy with a peanut patch among peanut-allergic children.

Design, Setting, And Participants: Phase 3, randomized, double-blind, placebo-controlled trial conducted at 31 sites in 5 countries between January 8, 2016, and August 18, 2017. Read More

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2019.1113DOI Listing
February 2019
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Management of Biological Therapy Before Elective Inflammatory Bowel Disease Surgeries.

Inflamm Bowel Dis 2019 Feb 22. Epub 2019 Feb 22.

Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Increasing uptake of biologic therapy has contributed to declining surgical rates for inflammatory bowel disease (IBD). However, a significant number of patients on biologic therapy will go on to require surgery. The literature is conflicted with regard to the preoperative management of biologic therapy before urgent or elective IBD surgery. Read More

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http://dx.doi.org/10.1093/ibd/izz002DOI Listing
February 2019

"These Few Blocks, These Are My Village": The Physical Activity and Mobility of Foreign-Born Older Adults.

Gerontologist 2019 Feb 22. Epub 2019 Feb 22.

Centre for Hip Health and Mobility, University of British Columbia and Vancouver Coastal Health Research Institute, Canada.

Background And Objectives: The self-reported health of foreign-born older adults (FBOAs) is lower than that of nonimmigrant peers. Physical activity (PA) and mobility enhance health in older age, yet we know very little about the PA and mobility of FBOAs. In this analysis we sought to determine: (a) What factors facilitate PA amongst FBOAs? and (b) How do gender, culture, and personal biography affect participants' PA and mobility?

Research Design And Methods: We worked closely with community partners to conduct a mixed-method study in Vancouver, Canada. Read More

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http://dx.doi.org/10.1093/geront/gnz005DOI Listing
February 2019

Cognitive neuropsychiatric analysis of an additional large Capgras delusion case series.

Cogn Neuropsychiatry 2019 Feb 22:1-12. Epub 2019 Feb 22.

a Division of Psychiatry , University College London (UCL) , London , UK.

: Although important to cognitive neuropsychiatry and theories of delusions, Capgras delusion has largely been reported in single case studies. Bell et al. [2017. Read More

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http://dx.doi.org/10.1080/13546805.2019.1584098DOI Listing
February 2019

An 'experimental' instrument: testing the torsion balance in Britain, Canada and Australia.

Ann Sci 2019 Feb 22:1-29. Epub 2019 Feb 22.

a Humanities , York University , Toronto , Canada.

The torsion balance, an instrument that was first developed to demonstrate the high precision of physical science in the laboratory became a different sort of demonstration instrument in its brief vogue in the 1920s. This article considers intersecting stories of acquiring and testing the torsion balance as a field instrument in Canada, Britain and Australia. It examines the purchasing trip and fieldwork of A. Read More

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http://dx.doi.org/10.1080/00033790.2019.1578897DOI Listing
February 2019

Mental health training, attitudes toward support, and screening positive for mental disorders.

Cogn Behav Ther 2019 Feb 22:1-19. Epub 2019 Feb 22.

j Hill / Levene Schools of Business, Faculty of Business Administration , University of Regina , Regina , SK , Canada.

Public Safety Personnel (PSP; e.g. correctional workers, dispatchers, firefighters, paramedics, police) are frequently exposed to potentially traumatic events (PTEs). Read More

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http://dx.doi.org/10.1080/16506073.2019.1575900DOI Listing
February 2019

Evaluation of the predictive performance of physiologically based pharmacokinetic models for intramuscular injections of therapeutic proteins.

Xenobiotica 2019 Feb 22:1-11. Epub 2019 Feb 22.

a Faculty of Pharmaceutical Sciences , The University of British Columbia , Vancouver , BC , Canada.

Several physiologically-based pharmacokinetic (PBPK) models have been reported for intravenous (IV) and subcutaneous (SC) injections, but there has been a paucity of work for intramuscular (IM) injections. The primary objective of this work was a wide-scale evaluation of the predictive performance of IM PBPK models of therapeutic proteins. PBPK models for all administration routes available in the literature have regarded muscle as the total muscle (TM) in the body; however, anatomically, the body is composed of discrete muscle groups. Read More

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http://dx.doi.org/10.1080/00498254.2019.1571651DOI Listing
February 2019

Reply to "Dual-Energy CT Iodine Mapping and 40-keV Monoenergetic Applications in the Diagnosis of Acute Bowel Ischemia: A Necessary Clarification".

AJR Am J Roentgenol 2019 Mar;212(3):W95

1 University of British Columbia, Vancouver, BC, Canada

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http://dx.doi.org/10.2214/AJR.18.20646DOI Listing

The New/Novel Oral Anticoagulants and Their Impact on Patients Being Considered for Shock Wave Lithotripsy: The Findings of an International Survey of the Endourological Society.

J Endourol 2019 Feb 22. Epub 2019 Feb 22.

Western University, Division of Urology, Department of Surgery, London, Ontario, Canada ;

Introduction: Although general guidelines exist directing the management of new/novel oral anticoagulants (NOACs) in the perioperative period for open/endoscopic procedures, no consensus exists for those patients being considered for shock wave lithotripsy (SWL). In order to gauge current practice, we administered a survey to the international endourological community.

Methods: A web-based survey was sent to current Endourological Society members. Read More

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http://dx.doi.org/10.1089/end.2019.0057DOI Listing
February 2019

Comprehensive data analysis for development of custom qRT-PCR miRNA assay for glioblastoma: a prevalidation study.

Epigenomics 2019 Feb 22. Epub 2019 Feb 22.

Department of Medical Biochemistry & Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt.

Aim: Glioblastoma (GB) is one notable example of miRNA-modulated neoplasms. Given its unique expression signature, proper miRNA profiling can help discriminate between GB and other types of brain tumors. The current work aimed to develop a more GB-specific and applicable custom designed quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) miRNA assay. Read More

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http://dx.doi.org/10.2217/epi-2018-0134DOI Listing
February 2019

The genotypic spectrum of ALDH7A1 mutations resulting in pyridoxine dependent epilepsy: A common epileptic encephalopathy.

J Inherit Metab Dis 2019 Feb 22. Epub 2019 Feb 22.

Section of Clinical Genetics and Metabolism, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA.

Pyridoxine dependent epilepsy (PDE) is a treatable epileptic encephalopathy characterized by a positive response to pharmacologic doses of pyridoxine. Despite seizure control, at least 75% of individuals have intellectual disability and developmental delay. Current treatment paradigms have resulted in improved cognitive outcomes emphasizing the importance of an early diagnosis. Read More

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http://dx.doi.org/10.1002/jimd.12045DOI Listing
February 2019

Pre-surgical Caregiver Burden and Anxiety Are Associated with Post-Surgery Cortisol over the Day in Caregivers of Coronary Artery Bypass Graft Surgery Patients.

Int J Behav Med 2019 Feb 21. Epub 2019 Feb 21.

Department of Behavioural Science and Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK.

Background: The relationship between pre-surgical distress and diurnal cortisol following surgery has not been investigated prospectively in caregivers of coronary artery bypass graft (CABG) patients before. We aimed to examine the relationship between pre-surgical anxiety and caregiver burden and diurnal cortisol measured 2 months after the surgery in the caregivers of CABG patients.

Method: We used a sample of 103 caregivers of elective CABG patients that were assessed 28. Read More

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http://dx.doi.org/10.1007/s12529-019-09775-6DOI Listing
February 2019

LIONS: Analysis Suite for Detecting and Quantifying Transposable Element Initiated Transcription from RNA-seq.

Bioinformatics 2019 Feb 21. Epub 2019 Feb 21.

Terry Fox Laboratory, BC Cancer, Vancouver, BC, Canada.

Summary: Transposable Elements (TEs) influence the evolution of novel transcriptional networks yet the specific and meaningful interpretation of how TE derived transcriptional initiation contributes to the transcriptome has been marred by computational and methodological deficiencies. We developed LIONS for the analysis of RNA-seq data to specifically detect and quantify TE-initiated transcripts.

Availability: Source code, container, test data and instruction manual are freely available at www. Read More

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http://dx.doi.org/10.1093/bioinformatics/btz130DOI Listing
February 2019

Phagocytosis of by Human Bronchial Epithelial Cells Is Mediated by the Arp2/3 Complex and WIPF2.

Front Cell Infect Microbiol 2019 7;9:16. Epub 2019 Feb 7.

Centre for Heart Lung Innovation, University of British Columbia and St. Paul's Hospital, Vancouver, BC, Canada.

is an opportunistic fungal pathogen capable of causing severe infection in humans. One of the limitations in our understanding of how causes infection concerns the initial stages of infection, notably the initial interaction between inhaled spores or conidia and the human airway. Using publicly-available datasets, we identified the Arp2/3 complex and the WAS-Interacting Protein Family Member 2 WIPF2 as being potentially responsible for internalization of conidia by airway epithelial cells. Read More

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http://dx.doi.org/10.3389/fcimb.2019.00016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375057PMC
February 2019

Health Professional-Identified Barriers to Living Donor Kidney Transplantation: A Qualitative Study.

Can J Kidney Health Dis 2019 13;6:2054358119828389. Epub 2019 Feb 13.

Division of Nephrology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada.

Background: Living donor kidney transplantation (LDKT) has several advantages over deceased donor kidney transplantation. Yet rates of living donation are declining in Canada and there exists significant interprovincial variability. Efforts to improve living donation tend to focus on the patient and barriers identified at their level, such as not knowing how to ask for a kidney or lack of education. Read More

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http://dx.doi.org/10.1177/2054358119828389DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376531PMC
February 2019

Herbivore-specific induction of indirect and direct defensive responses in leaves and roots.

AoB Plants 2019 Feb 1;11(1):plz003. Epub 2019 Feb 1.

School of Life Sciences, Henan University, Kaifeng, Henan, China.

Herbivory can induce both general and specific responses in plants that modify direct and indirect defence against subsequent herbivory. The type of induction (local versus systemic induction, single versus multiple defence induction) likely depends both on herbivore identity and relationships among different responses. We examined the effects of two above-ground chewing herbivores (caterpillar, weevil) and one sucking herbivore (aphid) on indirect defence responses in leaves and direct defence responses in both leaves and roots of tallow tree, We also included foliar applications of methyl jasmonate (MeJA) and salicylic acid (SA). Read More

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http://dx.doi.org/10.1093/aobpla/plz003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378760PMC
February 2019

All-terrain vehicle serious injuries and death in children and youth: A national survey of Canadian paediatricians.

Paediatr Child Health 2019 Feb 18;24(1):e13-e18. Epub 2018 Jun 18.

Department of Paediatrics, University of Toronto, Toronto, Ontario.

Background: All-Terrain Vehicles (ATVs) are a leading cause of serious injury in children and youth. Certain Canadian regions have implemented legislation to promote safety, including age restrictions, mandatory training and helmet use. Jurisdictions with more stringent ATV safety legislation have been shown to have reduced injury rates in the short term. Read More

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http://dx.doi.org/10.1093/pch/pxy059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376310PMC
February 2019

Management practice-related and modifiable factors associated with paediatric emergency return visits.

Paediatr Child Health 2019 Feb 7;24(1):e1-e7. Epub 2018 Apr 7.

Department of    Pediatrics, BC Children's Hospital Research Institute, University of   British Columbia, Vancouver, British Columbia.

Objectives: We explored practice-related factors associated with preventable unscheduled return visits to an emergency department (RTED).

Methods: We conducted a retrospective cohort study, using standardized review of health records. We included all visits with at least one RTED within 7 days of the index visit. Read More

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http://dx.doi.org/10.1093/pch/pxy039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376311PMC
February 2019

Krill faecal pellets drive hidden pulses of particulate organic carbon in the marginal ice zone.

Nat Commun 2019 Feb 21;10(1):889. Epub 2019 Feb 21.

British Antarctic Survey, Cambridge, CB3 0ET, UK.

The biological carbon pump drives a flux of particulate organic carbon (POC) through the ocean and affects atmospheric levels of carbon dioxide. Short term, episodic flux events are hard to capture with current observational techniques and may thus be underrepresented in POC flux estimates. We model the potential hidden flux of POC originating from Antarctic krill, whose swarming behaviour could result in a major conduit of carbon to depth through their rapid exploitation of phytoplankton blooms and bulk egestion of rapidly sinking faecal pellets (FPs). Read More

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http://dx.doi.org/10.1038/s41467-019-08847-1DOI Listing
February 2019

Effects of bleaching-associated mass coral mortality on reef structural complexity across a gradient of local disturbance.

Sci Rep 2019 Feb 21;9(1):2512. Epub 2019 Feb 21.

Department of Biology, University of Victoria, Victoria, British Columbia, V8P 5C2, Canada.

Structural complexity underpins the ecological functioning of coral reefs. However, rising ocean temperatures and associated coral bleaching threaten the structural integrity of these important ecosystems. Despite the increased frequency of coral bleaching events, few studies to date have examined changes in three-dimensional (3D) reef structural complexity following severe bleaching. Read More

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http://dx.doi.org/10.1038/s41598-018-37713-1DOI Listing
February 2019

Golden girl Muir smashes British record.

Authors:

Vet Rec 2019 Feb;184(8):236

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http://dx.doi.org/10.1136/vr.l812DOI Listing
February 2019

Copenhagen Consensus statement 2019: physical activity and ageing.

Br J Sports Med 2019 Feb 21. Epub 2019 Feb 21.

Department of Physiology, Universitat de Valencia, Valencia, Spain.

From 19th to 22nd November 2018, 26 researchers representing nine countries and a variety of academic disciplines met in Snekkersten, Denmark, to reach evidence-based consensus about physical activity and older adults. It was recognised that the term 'older adults' represents a highly heterogeneous population. It encompasses those that remain highly active and healthy throughout the life-course with a high intrinsic capacity to the very old and frail with low intrinsic capacity. Read More

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http://dx.doi.org/10.1136/bjsports-2018-100451DOI Listing
February 2019

Diagnosis and management of acute lower gastrointestinal bleeding: guidelines from the British Society of Gastroenterology.

Gut 2019 Feb 12. Epub 2019 Feb 12.

Department of Surgery and Cancer, Imperial College, London, UK.

This is the first UK national guideline to concentrate on acute lower gastrointestinal bleeding (LGIB) and has been commissioned by the Clinical Services and Standards Committee of the British Society of Gastroenterology (BSG). The Guidelines Development Group consisted of representatives from the BSG Endoscopy Committee, the Association of Coloproctology of Great Britain and Ireland, the British Society of Interventional Radiology, the Royal College of Radiologists, NHS Blood and Transplant and a patient representative. A systematic search of the literature was undertaken and the quality of evidence and grading of recommendations appraised according to the GRADE(Grading of Recommendations Assessment, Development and Evaluation) methodology. Read More

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http://dx.doi.org/10.1136/gutjnl-2018-317807DOI Listing
February 2019

Stereotactic Body Radiotherapy for Small Unresectable Hepatocellular Carcinomas.

Clin Oncol (R Coll Radiol) 2019 Feb 18. Epub 2019 Feb 18.

Department of Radiation Oncology, British Columbia Cancer Agency, Vancouver Center, Vancouver, British Columbia, Canada. Electronic address:

Aims: Stereotactic body radiotherapy (SBRT) is an option for the treatment of hepatocellular carcinoma (HCC) in patients ineligible for standard local therapies. This study reports on the safety and efficacy of SBRT in small HCC tumours (≤5 cm) in the province of British Columbia.

Materials And Methods: Between March 2011 and July 2015, 31 patients with Child-Pugh Class A or B, with small HCCs measuring ≤5 cm were treated with SBRT at our institution. Read More

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http://dx.doi.org/10.1016/j.clon.2019.01.012DOI Listing
February 2019

The Hans Eysenck affair: Time to correct the scientific record.

Authors:
David F Marks

J Health Psychol 2019 Feb 22:1359105318820931. Epub 2019 Feb 22.

Editor, Journal of Health Psychology and Health Psychology Open.

The Journal of Health Psychology publishes here Dr Anthony Pelosi's analysis of questionable science by one of the world's best-known psychologists, the late Professor Hans J Eysenck. The provenance of a huge body of data produced by Eysenck and Ronald Grossarth-Maticek is highly controversial. In Open letters to King's College London and the British Psychological Society, this editor is requesting a thorough investigation of the facts together with retraction or correction of 61 publications. Read More

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http://dx.doi.org/10.1177/1359105318820931DOI Listing
February 2019

Health Literacy Among Canadian Men Experiencing Prostate Cancer.

Health Promot Pract 2019 Feb 21:1524839919827576. Epub 2019 Feb 21.

6 Griffith University, Brisbane, Queensland, Australia.

The objective was to describe the health literacy of a sample of Canadian men with prostate cancer and explore whether sociodemographic and health factors were related to men's health literacy scores. A sample of 213 Canadian men ( M age = 68.71 years, SD = 7. Read More

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http://dx.doi.org/10.1177/1524839919827576DOI Listing
February 2019

Modifying a Paediatric Rational Prescribing Tool (POPI) for Use in the UK.

Healthcare (Basel) 2019 Feb 20;7(1). Epub 2019 Feb 20.

Division of Medical Sciences & Graduate Entry Medicine, University of Nottingham, Royal Derby Hospital Centre, Uttoxeter Road, Derby, DE22 3DT, UK.

Rational prescribing tools can be used by individual prescribers, organisations, and researchers to evaluate the quality of prescribing for research and quality improvement purposes. A literature search showed that there is only one tool for evaluating rational prescribing for paediatric patients in hospital and outpatient settings. The Pediatrics: Omission of Prescriptions and Inappropriate Prescriptions (POPI) tool was developed in France and comprises 105 criteria. Read More

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http://dx.doi.org/10.3390/healthcare7010033DOI Listing
February 2019

Computer-Aided Discovery of Small Molecules Targeting the RNA Splicing Activity of hnRNP A1 in Castration-Resistant Prostate Cancer.

Molecules 2019 Feb 20;24(4). Epub 2019 Feb 20.

Vancouver Prostate Centre, University of British Columbia, 2660 Oak Street, Vancouver, BC V6H 3Z6, Canada.

The heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is a versatile RNA-binding protein playing a critical role in alternative pre-mRNA splicing regulation in cancer. Emerging data have implicated hnRNP A1 as a central player in a splicing regulatory circuit involving its direct transcriptional control by c-Myc oncoprotein and the production of the constitutively active ligand-independent alternative splice variant of androgen receptor, AR-V7, which promotes castration-resistant prostate cancer (CRPC). As there is an urgent need for effective CRPC drugs, targeting hnRNP A1 could, therefore, serve a dual purpose of preventing AR-V7 generation as well as reducing c-Myc transcriptional output. Read More

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http://dx.doi.org/10.3390/molecules24040763DOI Listing
February 2019

Impact on immigrant screening adherence with introduction of a population-based colon screening program in Ontario, Canada.

Cancer Med 2019 Feb 21. Epub 2019 Feb 21.

School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada.

Introduction: The literature suggests that differential colorectal cancer (CRC) screening adherence exists between Canada's immigrant and nonimmigrant populations. This study explores the impact of Ontario's population screening program, ColonCancerCheck, on CRC screening uptake in immigrant and nonimmigrant population groups.

Methods: Data from 2005, 2007-2008, and 2011-2012 was obtained from the Canadian Community Health Survey, to represent the intervention periods (the time periods before, during, and after implementation of the ColonCancerCheck intervention). Read More

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http://dx.doi.org/10.1002/cam4.2026DOI Listing
February 2019

Postural Threat Modulates Perceptions of Balance-Related Movement during Support Surface Rotations.

Neuroscience 2019 Feb 18. Epub 2019 Feb 18.

School of Kinesiology, University of British Columbia, Vancouver, BC, Canada; International Collaboration for Repair Discoveries, University of British Columbia, Vancouver, BC, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada. Electronic address:

Postural threat decreases center of pressure displacements yet increases the magnitude of movement-related conscious sway perception during quiet standing. It is unknown how these changes influence perception of whole body movement during dynamic stance. The aim of this study was to examine how postural threat influences whole-body movements and conscious perception of these movements during continuous pseudo-random support surface perturbations to stance. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.02.011DOI Listing
February 2019

The stability of health-related behaviour clustering during mid-adulthood and the influence of social circumstances on health-related behaviour change.

Prev Med 2019 Feb 18. Epub 2019 Feb 18.

International Centre for Lifecourse Studies in Society and Health, Research Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, United Kingdom. Electronic address:

Evidence suggests that health-related behaviours (HRBs) cluster in mid-adulthood and are associated with social circumstances (i.e. economic circumstances, cultural norms, employment relations) at the same age. Read More

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http://dx.doi.org/10.1016/j.ypmed.2019.02.009DOI Listing
February 2019

Assessing Research Gaps and Unmet Needs in Endometriosis.

Am J Obstet Gynecol 2019 Feb 18. Epub 2019 Feb 18.

Society for Women's Health Research, Washington, DC, USA. Electronic address:

Endometriosis, a systemic disease that is often painful and chronic, affects ∼10% of reproductive-age women. The disease can negatively impact a patient's physical and emotional well-being, quality of life, and productivity. Endometriosis also places significant economic and social burden on patients, their families, and society as a whole. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.02.033DOI Listing
February 2019

Characterization of novel kainic acid analogs as inhibitors of select microglial functions.

Eur J Pharmacol 2019 Feb 18. Epub 2019 Feb 18.

Department of Biology, University of British Columbia Okanagan Campus, Kelowna, BC, Canada. Electronic address:

Alzheimer's disease (AD) is characterized by abnormal accumulation of extracellular amyloid beta protein (Aβ) plaques and intracellular neurofibrillary tangles, as well as by a state of chronic inflammation in the central nervous system (CNS). Adverse activation of microglia, the brain immune cells, is believed to contribute to AD pathology including excessive neuronal death. Thus, normalizing immune functions of microglia could slow neurodegeneration, and identification of novel compounds capable of modifying microglial functions is an important goal. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.02.025DOI Listing
February 2019

Heritability estimates of fractures in Japanese Thoroughbred racehorses using a non-linear model.

J Anim Breed Genet 2019 Feb 21. Epub 2019 Feb 21.

Genetic Analysis Department, Laboratory of Racing Chemistry, Utsunomiya, Japan.

Thoroughbred racehorses are produced by mating small numbers of Arabian stallions and native British mares, and have been improved by selection of horseracing performance for about 300 years. While these improvements led to good performance as racehorses, they exposed horses to numerous medical disorders, aggravated by extensive exercise. Fractures are frequent medical disorders in Thoroughbred racehorses. Read More

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http://dx.doi.org/10.1111/jbg.12387DOI Listing
February 2019

Siphonariid development: Quintessential euthyneuran larva with a mantle fold innovation (Gastropoda; Panpulmonata).

J Morphol 2019 Feb 21. Epub 2019 Feb 21.

Department of Biological Sciences, 331 Funchess Hall, University of Auburn, Auburn, Alabama.

Recent phylogenetic revisions of euthyneuran gastropods ("opisthobranchs" and "pulmonates") suggest that clades with a planktotrophic larva, the ancestral life history for euthyneurans, are more widely distributed along the trunk of the euthyneuran tree than previously realized. There is some indication that the planktotrophic larva of euthyneurans has distinctive features, but information to date has come mainly from traditional "opisthobranch" groups. Much less is known about planktotrophic "pulmonate" larvae. Read More

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http://dx.doi.org/10.1002/jmor.20971DOI Listing
February 2019

Diagnostic Accuracy in Fit-for-Purpose PD-L1 Testing.

Appl Immunohistochem Mol Morphol 2019 Feb 15. Epub 2019 Feb 15.

Canadian Immunohistochemistry Quality Control.

PD-L1 testing by immunohistochemistry (IHC) has presented significant challenges not only for clinical laboratories, but also for external quality assurance (EQA) entities that provide proficiency testing (PT) for clinical laboratories. Canadian Immunohistochemistry Quality Control (CIQC) has used educational runs to explore approaches to sample design and analysis of results that would enhance patient safety. As PT for predictive biomarkers requires modeling at every level (design of the run, assessment of the run, and reporting of "pass" or "fail") based on "fit-for-purpose" principles, CIQC has applied those principles to PD-L1 PT runs. Read More

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http://dx.doi.org/10.1097/PAI.0000000000000734DOI Listing
February 2019

Differential association between the progression of coronary artery calcium score and coronary plaque volume progression according to statins: the Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging (PARADIGM) study.

Eur Heart J Cardiovasc Imaging 2019 Feb 20. Epub 2019 Feb 20.

Division of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, Seoul 03722, South Korea.

Aims: Coronary artery calcium score (CACS) is a strong predictor of major adverse cardiac events (MACE). Conversely, statins, which markedly reduce MACE risk, increase CACS. We explored whether CACS progression represents compositional plaque volume (PV) progression differently according to statin use. Read More

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http://dx.doi.org/10.1093/ehjci/jez022DOI Listing
February 2019

The bougie and first-pass success in the emergency department: Journal Club review.

CJEM 2019 Feb 21:1-3. Epub 2019 Feb 21.

†Department of Emergency Medicine,The University of British Columbia,Vancouver, BC.

Clinical Question: Is bougie use associated with increased first-pass success in emergency department (ED) intubations?Article chosen: Driver et al. The Bougie and First-Pass Success in the Emergency Department. Annals of Emerg Med 2017;70(4):473-478. Read More

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http://dx.doi.org/10.1017/cem.2018.502DOI Listing
February 2019

Gender differences amongst board members of endocrinology and diabetes societies.

Endocrine 2019 Feb 20. Epub 2019 Feb 20.

Department of Radiology, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada.

Purpose: Although women's status has shown marked improvement over the years in many areas, women still face a gender bias, especially in the workforce. Despite the best efforts of organizations to promote diversity and equality, women still dominate the lower-paying administrative ranks while men continue to dominate at the executive level. The present study examines gender disparity in the leadership positions in the national and international endocrinology and diabetes societies across the globe. Read More

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http://dx.doi.org/10.1007/s12020-019-01861-9DOI Listing
February 2019

Rectal cancer DFP dedicated issue: abdominal radiology : The role of ERUS in staging of primary rectal cancer: a surgeon's perspective.

Authors:
P Terry Phang

Abdom Radiol (NY) 2019 Feb 20. Epub 2019 Feb 20.

University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/s00261-019-01949-wDOI Listing
February 2019

Dyslipidemia: The untreated metabolic dysfunction in people with type 2 diabetes in Latin America. ARETAEUS study outcomes.

J Clin Transl Endocrinol 2019 Mar 25;15:76-80. Epub 2019 Jan 25.

Merck & Co., Inc., Kenilworth, NJ, USA.

Objective: To assess oral antihyperglycemic agents (OAHA) and/or statin treatment initiation in patients with type 2 diabetes (T2D) and time from diagnosis to both types of treatment initiation and intensification.

Research Design And Methods: We reviewed 662 retrospective medical records of patients with T2D diagnosed by 31 general practitioner or specialist sites across Mexico, Argentina, and Brazil. Demographic and clinical information was abstracted from patients' medical records and summarized using descriptive statistics. Read More

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http://dx.doi.org/10.1016/j.jcte.2019.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369257PMC

Co-building a patient-oriented research curriculum in Canada.

Res Involv Engagem 2019 11;5. Epub 2019 Feb 11.

6Centre for Pedagogy Applied to the Health Sciences, Department of Family Medicine and Emergency Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC Canada.

Plain English Summary: is a course designed and piloted in Canada to help patients, researchers, health care professionals and health system decision-makers gain an introductory understanding of patient-oriented research, the research enterprise, and how to work in a team. The course curriculum was co-developed by a diverse group of people with different lived experiences and relevant expertise. The course is meant to be delivered in a 'co-learning format' with classes comprised of all the above stakeholder groups learning together. Read More

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http://dx.doi.org/10.1186/s40900-019-0141-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369555PMC
February 2019