143,383 results match your criteria British journal of haematology[Journal]


Expostats: A Bayesian Toolkit to Aid the Interpretation of Occupational Exposure Measurements.

Ann Work Expo Health 2018 Dec 14. Epub 2018 Dec 14.

Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

Introduction: Interpretation of exposure measurements has evolved into a framework based on the lognormal distribution. Most available practical tools are based on traditional frequentist statistical procedures that do not satisfactorily account for censored data and are not amenable to simple probabilistic risk statements. Bayesian methods offer promising solutions to these challenges. Read More

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December 2018

Lacking evidence for the association between frequent urine drug screening and health outcomes of persons on opioid agonist therapy.

Int J Drug Policy 2018 Dec 11;64:30-33. Epub 2018 Dec 11.

British Columbia Centre on Substance Use, 400-1045 Howe Street, Vancouver, BC, V6Z 2A9, Canada; Department of Medicine, University of British Columbia, St. Paul's Hospital, 608-1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada; School of Medicine, University College Dublin, Health Sciences Centre, Belfield, Dublin 4, Ireland. Electronic address:

Background: Opioid agonist therapy (OAT) is a first-line treatment for opioid use disorder (OUD); however, the efficacy and role of urine drug screening (UDS) in OAT has received little research attention. Prior evidence suggests that UDS frequency reflects philosophy and practice context rather than differences in patient characteristics or clinical need. Therefore, we reviewed the literature on the effect of and recommendations for the frequency of UDS on health outcomes for persons with OUD who receive OAT. Read More

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December 2018

The T-type calcium channel antagonist, Z944, alters social behavior in Genetic Absence Epilepsy Rats from Strasbourg.

Behav Brain Res 2018 Dec 11. Epub 2018 Dec 11.

University of Saskatchewan, Department of Physiology, Saskatoon, SK, Canada.

Abnormalities in social behavior are a co-morbid symptom of idiopathic generalized epilepsies such as childhood absence epilepsy. The Genetic Absence Epilepsy Rats from Strasbourg (GAERS) model is a spontaneously occurring absence epilepsy phenotype closely correlated to that of human absence epilepsies. Similar to the human conditions, GAERS display social abnormalities. Read More

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December 2018

Rehabilitation-induced brain changes detected through magnetic resonance imaging in children with neurodevelopmental disorders: A systematic review.

Int J Dev Neurosci 2018 Dec 11. Epub 2018 Dec 11.

Department of Occupational Science & Occupational Therapy, University of British Columbia, Vancouver, Canada; BC Children's Hospital Research Institute, Vancouver, Canada; Department of Pediatrics, University of British Columbia, Vancouver, Canada; Sunny Hill Health Centre for Children, Vancouver, Canada. Electronic address:

Aim: The aim of this study was to systematically review evidence about rehabilitation-induced neuroplasticity measured by magnetic resonance imaging (MRI) in children with neurodevelopmental disorders.

Method: The following databases were searched: MEDLINE, EMBASE, CINAHL, and PsycINFO. Two independent reviewers screened articles according to inclusion criteria: (1) peer-review study published in a scientific journal; (2) studies that evaluated a rehabilitation-based intervention; (3) participants aged less than 19 years with a neurodevelopmental disorder; (4) studies that used at least one MRI modality as an outcome measure. Read More

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December 2018

Endometrial Carcinoma Diagnosis: Use of FIGO Grading and Genomic Subcategories in Clinical Practice: Recommendations of the International Society of Gynecological Pathologists.

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S64-S74

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York (R.A.S, K.J.P.) Department of Pathology, Stony Brook Hospital, SUNY, Stony Brook (C.T.), New York Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (A.M.) Pathology Department, University Hospital Arnau de Vilanova and University Hospital of Bellvitge, Biomedical Research Institute, and Bellvitge Biomedical Institute, University of Lleida, CIBERONC, Spain (X.M.-G.) Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts (E.O.) Department of Pathology, Yale School of Medicine and the Yale School of Public Health, New Haven, Connecticut (V.P.) Department of Oncology-Pathology, Karolinska Institutet and Department of Pathology and Cytology, Karolinska University Hospital, Stockholm, Sweden (J.C.) Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK (W.G.M.) Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, BC, Canada (C.B.G.).

In this review, we sought to address 2 important issues in the diagnosis of endometrial carcinoma: how to grade endometrial endometrioid carcinomas and how to incorporate the 4 genomic subcategories of endometrial carcinoma, as identified through The Cancer Genome Atlas, into clinical practice. The current International Federation of Gynecology and Obstetrics grading scheme provides prognostic information that can be used to guide the extent of surgery and use of adjuvant chemotherapy or radiation therapy. We recommend moving toward a binary scheme to grade endometrial endometrioid carcinomas by considering International Federation of Gynecology and Obstetrics defined grades 1 and 2 tumors as "low grade" and grade 3 tumors as "high grade. Read More

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January 2019

High-grade Endometrial Carcinomas: Morphologic and Immunohistochemical Features, Diagnostic Challenges and Recommendations.

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S40-S63

Department of Pathology, Memorial Sloan Kettering Cancer Center (R.M., R.A.S.) New York University Medical Center and School of Medicine, Tisch Hospital (K.M.), New York Department of Pathology, University Hospital, Stony Brook School of Medicine, Stony Brook (C.T.), New York Department of Pathology, Oslo University Hospital, Norwegian Radium Hospital; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway (B.D.) Department of Pathology, University of California San Diego, San Diego (O.F.) Department of Pathology, Cedars-Sinai Medical Center, Los Angeles (J.K.L.R.), California Department of Pathology, Karolinska Institutet, Stockholm, Sweden (J.A.C.) Department of Pathology, Brigham and Women's Hospital, Harvard Medical School (C.P.C.) Department of Pathology, Massachussetts General Hospital, Harvard Medical School (E.O.), Boston, Massachussetts Department of Pathology, University of British Columbia, Vancouver (C.B.G., J.A.I.) Department of Laboratory Medicine, Pathology and Medical Genetics, Royal Jubilee Hospital, Victoria (J.A.I.), BC, Canada Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas (A.M.) Department of Pathology, Hospital University Arnau de Vilanova; and Department of Pathology, Hospital University de Bellvitge, IRBLLEIDA, IDIBELL, University of Lleida, CIBERONC, Barcelona, Spain (X.M.-G.) Department of Pathology, Belfast Health and Social Care Trust, Belfast, UK (W.G.M.) Department of Pathology and Obstetrics and Gynecology, Yale School of Medicine and Yale School of Publich Health, New Haven, Connecticut (V.P.) Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland (P.N.S.) Department of Pathology, KEMH and School for Women's and Infants' Health, University of Western Australia, Perth, WA, Australia (C.J.R.S.).

This review of challenging diagnostic issues concerning high-grade endometrial carcinomas is derived from the authors' review of the literature followed by discussions at the Endometrial Cancer Workshop sponsored by the International Society of Gynecological Pathologists in 2016. Recommendations presented are evidence-based, insofar as this is possible, given that the levels of evidence are weak or moderate due to small sample sizes and nonuniform diagnostic criteria used in many studies. High-grade endometrioid carcinomas include FIGO grade 3 endometrioid carcinomas, serous carcinomas, clear cell carcinomas, undifferentiated carcinomas, and carcinosarcomas. Read More

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January 2019

Issues in the Differential Diagnosis of Uterine Low-grade Endometrioid Carcinoma, Including Mixed Endometrial Carcinomas: Recommendations from the International Society of Gynecological Pathologists.

Int J Gynecol Pathol 2019 Jan;38 Suppl 1:S25-S39

Pathology Department, University of California San Francisco, San Francisco, California (J.T.R.) Department of Pathology and Laboratory Medicine, Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, Canada (C.B.G.) Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas (A.M.) Department of Pathology, University Hospital Arnau de Vilanova and Department of Pathology, University Hospital de Bellvitge, University of Lleida, IRBLLEIDA, IDIBELL, CIBERONC, Spain (X.M.G.) Department of Pathology, New York University Langone Medical Center, New York, New York (K.M.) Department of Pathology, Brigham and Women's Hospital (G.L.M.) Pathology Department, Massachusetts General Hospital (E.O.), Boston, Massachusetts Pathology Department, Yale New Haven Hospital, New Haven, Connecticut (V.P.) Department of Pathology, Johns Hopkins Medical Institutions (B.M.R.) Department of Pathology, University of Maryland School of Medicine (P.S.), Baltimore, Maryland Department of Histopathology, King Edward Memorial Hospital and School for Women's and Infants' Health, University of Western Australia, Perth, Australia (C.J.R.S.) Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland, UK (W.G.M.).

This article provides practical recommendations developed from the International Society of Gynecological Pathologists Endometrial Carcinoma Project to address 4 issues that may arise in the diagnosis of uterine corpus low-grade endometrioid carcinoma: (1) The distinction between atypical hyperplasia and low-grade endometrioid carcinoma. (2) The distinction between low-grade endometrioid carcinoma and serous carcinoma. (3) The distinction between corded and hyalinized or spindle cell variants of low-grade endometrioid carcinoma and carcinosarcoma. Read More

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January 2019

What Should a Psychiatrist Know About Genetics? Review and Recommendations From the Residency Education Committee of the International Society of Psychiatric Genetics.

J Clin Psychiatry 2018 Nov 27;80(1). Epub 2018 Nov 27.

Centre for Addiction and Mental Health and University of Toronto, Toronto, Ontario, Canada.

The International Society of Psychiatric Genetics (ISPG) created a Residency Education Committee with the purpose of identifying key genetic knowledge that should be taught in psychiatric training programs. Thirteen committee members were appointed by the ISPG Board of Directors, based on varied training, expertise, gender, and national origin. The Committee has met quarterly for the past 2 years, with periodic reports to the Board and to the members of the Society. Read More

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November 2018

Is extended red cell antigen matching of blood donors and recipients a practical reality?

Authors:
G D Poole

Transfus Med 2018 Dec;28(6):458-459

British Blood Transfusion Society, Enterprise House, Lloyd Street North, Manchester Science Park, Manchester, UK.

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December 2018

Spontaneous resolution of large pericardial effusion associated with right ventricular outpouching in four fetal cases.

Ultrasound Obstet Gynecol 2018 Dec 14. Epub 2018 Dec 14.

Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, Windsor Walk London, SE5 8BB, UK.

We report the diagnosis and management of four cases of right ventricular outpouching (RVO) in association with a large pericardial effusion. These fetuses initially presented with a large pericardial effusion (figure 1.a) before 16 weeks gestation. Read More

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December 2018

Genotype, extrapyramidal features and severity of variant Ataxia-Telangiectasia.

Ann Neurol 2018 Dec 14. Epub 2018 Dec 14.

Ataxia Telangiectasia Service, Respiratory Support and Sleep Centre, Papworth Hospital. Papworth Everard, Cambridge, CB23 3RE, UK.

Objective: Variant Ataxia-Telangiectasia is caused by mutations that allow some retained ATM kinase activity. Here, we describe the clinical features of the largest established cohort of individuals with variant Ataxia-Telangiectasia and explore genotype-phenotype correlations.

Methods: Cross-sectional data were collected retrospectively. Read More

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December 2018
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Bayesian latent class analysis of ELISA and RT-rPCR diagnostic accuracy for subclinical Renibacterium salmoninarum infection in Atlantic salmon (Salmo salar) broodstock.

J Fish Dis 2018 Dec 14. Epub 2018 Dec 14.

Marine Harvest Canada, Campbell River, British Columbia, Canada.

Renibacterium salmoninarum infection causes bacterial kidney disease (BKD) in salmonid freshwater and saltwater life stages, with potentially severe financial loss for the aquaculture industry. Preventing vertical transmission, from infected broodstock to eggs, is key to disease management. As there is no perfect reference standard for detecting R. Read More

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December 2018

Facile formation of β-thioGlcNAc linkages to thiol-containing sugars, peptides, and proteins using a mutant GH20 hexosaminidase.

Angew Chem Int Ed Engl 2018 Dec 13. Epub 2018 Dec 13.

University of British Columbia, Chemistry, 2036 Main Mall, V6T 1Z1, Vancouver, CANADA.

Thioglycosides are hydrolase-resistant mimics of O-linked glycosides that can serve as valuable probes for studying the role of glycosides in biological processes. Traditional chemical syntheses of thioglycoside analogues of O-GlcNAc-modified peptides and proteins require lengthy, multi-step approaches. We report the development of efficient, enzyme-mediated syntheses of thioglycosides, including S-GlcNAcylated proteins, using a thioglycoligase derived from a GH20 hexosaminidase from Streptomyces plicatus in which the catalytic acid/base glutamate has been replaced with an alanine (SpHex E314A). Read More

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December 2018

Tensions that define the State of our Science in 2019.

Authors:
Kevin W Eva

Med Educ 2019 Jan;53(1):1-2

Centre for Health Education Scholarship, University of British Columbia, Vancouver, British Columbia, Canada.

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January 2019

Developmental regulation of lifelong dental experiences and beliefs in Guangzhou and Hong Kong.

Gerodontology 2018 Dec 14. Epub 2018 Dec 14.

Cooperative Research Centre for Oral Health Science Melbourne Dental School, University of Melbourne, Melbourne, Victoria, Australia.

Aims: The aim of this study was to explain through the life-course and life-span perspectives of developmental regulation theory the controls on dental experiences and beliefs throughout the lives of older people in Guangzhou and Hong Kong.

Background: Dental diseases and disabilities among older people are serious public health concerns in China.

Methods: A facilitator conducted eight focus groups, three in Hong Kong and five in Guangzhou, involving a total of 51 participants. Read More

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December 2018

Beliefs about managing dental problems among older people and dental professionals in Southern Brazil.

Community Dent Oral Epidemiol 2018 Dec 13. Epub 2018 Dec 13.

Faculty of Dentistry, University of British Columbia, Vancouver, British Columbia, Canada.

Objectives: To explore the sociocultural context in which patients and dentists in urban and rural communities in Southern Brazil interpret dental problems.

Method: Beliefs and experiences related to dental problems were explored in eight focus groups involving a total of 41 older patients, and in direct interviews with two dentists and two dental assistants. The interactions were audio recorded and transcribed for thematic analysis. Read More

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December 2018

The ventilation mechanism of the Pacific hagfish Eptatretus stoutii.

J Fish Biol 2018 Dec 13. Epub 2018 Dec 13.

Department of Zoology, University of British Columbia, Vancouver, BC, Canada.

We made anatomical and physiological observations of the breathing mechanisms in Pacific hagfish Eptatretus stoutii, with measurements of nostril flow and pressure, mouth and pharyngo-cutaneous duct (PCD) pressure and velum and heart impedance and observations of dye flow patterns. Resting animals frequently exhibit spontaneous apnea. During normal breathing, water flow is continuous at a high rate (~125 ml kg min at 12°C) powered by a two-phase unidirectional pumping system with a fast suction pump (the velum, ~ 22 min ) for inhalation through the single nostril and a much slower force pump (gill pouches and PCD ~ 4. Read More

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December 2018

Myocardial Cell Signaling During the Transition to Heart Failure: Cellular Signaling and Therapeutic Approaches.

Compr Physiol 2018 Dec 13;9(1):75-125. Epub 2018 Dec 13.

St. Boniface Hospital Research Centre, Department of Physiology and Pathophysiology, University of Manitoba, Winnipeg, Canada.

Cardiovascular disease leading to heart failure (HF) remains a leading cause of morbidity and mortality worldwide. Improved pharmacological and interventional coronary procedures have led to improved outcomes following acute myocardial infarction. This success has translated into an unforeseen increased incidence in HF. Read More

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December 2018

Incisional negative pressure therapy reduces complications and costs in pressure ulcer reconstruction.

Authors:
Anthony A Papp

Int Wound J 2018 Dec 12. Epub 2018 Dec 12.

Vancouver General Hospital, Vancouver, British Columbia, Canada.

Complications after pressure ulcer reconstruction are common. A complication rate of 21% to 58% and a 27% wound recurrence has been reported. The aim of this study was to decrease postoperative wound-healing complications with incisional negative pressure wound therapy (iNPWT) postoperatively. Read More

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December 2018

Aging differentially modulates the Wnt pro-survival signalling pathways in vascular smooth muscle cells.

Aging Cell 2018 Dec 12:e12844. Epub 2018 Dec 12.

Bristol Medical School, University of Bristol, Bristol Royal Infirmary, Bristol, UK.

We previously reported pro-survival effects of Wnt3a and Wnt5a proteins in vascular smooth muscle cells (VSMCs). Wnt5a achieved this through induction of Wnt1-inducible signalling pathway protein-1 (WISP-1) consequent to β-catenin/CREB-dependent, TCF-independent, signalling. However, we found that as atherosclerosis advances, although Wnt5a protein was increased, WISP-1 was reduced. Read More

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December 2018

Declining population trends of European mountain birds.

Glob Chang Biol 2018 Dec 11. Epub 2018 Dec 11.

Dachverband Deutscher Avifaunisten (DDA) e.V., Geschäftsstelle, Münster, Germany.

Mountain areas often hold special species communities, and they are high on the list of conservation concern. Global warming and changes in human land use, such as grazing pressure and afforestation, have been suggested to be major threats for biodiversity in the mountain areas, affecting species abundance and causing distribution shifts towards mountaintops. Population shifts towards poles and mountaintops have been documented in several areas, indicating that climate change is one of the key drivers of species' distribution changes. Read More

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December 2018

Counselling for young people and young adults in the voluntary and community sector: An overview of the demographic profile of clients and outcomes.

Psychol Psychother 2018 Dec 11. Epub 2018 Dec 11.

University of Roehampton, London, UK.

Objectives: To determine the demographic profile of clients accessing voluntary and community sector (VCS) counselling services for young people and young adults, and to undertake the first systematic evaluation of outcomes.

Design: Naturalistic, non-experimental study design.

Methods: A total of 2,144 clients were recruited from nine services in England. Read More

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December 2018

Molecular characterization of a MLL1 fusion and its role in chromosomal instability.

Mol Oncol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology and Laboratory Medicine, Cancer Cluster, College of Medicine, University of Saskatchewan, Saskatoon, SK, S7N 5E5, Canada.

Chromosomal rearrangements involving the mixed-lineage leukemia (MLL1) gene are common in a unique group of acute leukemias, with more than 100 fusion partners in this malignancy alone. However, do these fusions occur or have a role in solid tumors? We performed extensive network analyses of MLL1-fusion partners in patient datasets, revealing that multiple MLL1-fusion partners exhibited significant interactions with the androgen-receptor signaling pathway. Further exploration of tumor sequence data from TCGA predicts the presence of MLL1 fusions with truncated SET domain in prostate tumors. Read More

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December 2018

'What's cooking?' A comparison of an activity-oriented and a table-top programme of therapy on the language performance of people with aphasia.

Int J Lang Commun Disord 2018 Dec 10. Epub 2018 Dec 10.

Research Department of Language and Cognition, Division of Psychology and Language Sciences, UCL, London, UK.

Background: Many people with aphasia have word-finding difficulties, with some showing particular difficulties with verbs. Picture-naming therapy is often used to improve naming, but gains are usually limited to therapy items and do not transfer to conversation. Therapy where words are produced in sentences and in real-life activities may be more effective. Read More

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December 2018

Nurse-Led Supportive Care Intervention for Men With Advanced Prostate Cancer.

Oncol Nurs Forum 2019 Jan;46(1):92-103

University of Southern Queensland.

Objectives: To understand the context for implementing ProsCare by prostate cancer specialist nurses (PCSNs) and, in doing so, further develop the intervention and implementation strategy.

Sample & Setting: 30 PCSNs participated in four semistructured focus groups to evaluate a telephone-based supportive care intervention led by nurses for men with advanced prostate cancer.

Methods & Variables: Data were coded into the Consolidated Framework for Implementation Research to evaluate the ProsCare program content and guide the implementation and evaluation of this targeted program for men with advanced prostate cancer. Read More

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January 2019

The Great British Drill Off is open for applications.

Authors:

Br Dent J 2018 Dec;225(11):1003

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December 2018

Folding mutations suppress early beta-cell proliferation.

Elife 2018 Dec 14;7. Epub 2018 Dec 14.

Diabetes Research Group, Life Sciences Institute, Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, Canada.

Exploring how proliferation and maturation of beta-cells can be impaired after birth will shed light on the origins of various forms of diabetes. Read More

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December 2018

First Direct Measurements of Superheavy-Element Mass Numbers.

Phys Rev Lett 2018 Nov;121(22):222501

Lawrence Livermore National Laboratory, Livermore, California 94550, USA.

An experiment was performed at Lawrence Berkeley National Laboratory's 88-in. Cyclotron to determine the mass number of a superheavy element. The measurement resulted in the observation of two α-decay chains, produced via the ^{243}Am(^{48}Ca,xn)^{291-x}Mc reaction, that were separated by mass-to-charge ratio (A/q) and identified by the combined BGS+FIONA apparatus. Read More

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November 2018

Solvent- and Temperature-Responsive Platinum(II)-Functionalized Flexible Lewis Pairs.

Inorg Chem 2018 Dec 14. Epub 2018 Dec 14.

Department of Chemistry , University of British Columbia , 2036 Main Mall , Vancouver , British Columbia V6T 1Z1 , Canada.

Metal-functionalized flexible Lewis pair (flexLP) complexes are described. Platinum(II) terpyridine (Pt-tpy) units added to a flexLP backbone through copper(I)-catalyzed coupling reactions yield monometallic (1) and bimetallic (2) Pt-tpy flexLP complexes. NMR and UV-vis absorption studies demonstrate that the complexes switch between the open unbound Lewis pair and closed Lewis adduct with solvents of varying hydrogen-bond-donating (HBD) strength as well as varying temperature. Read More

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December 2018

Paradigm Shifts in Gifted Education: An Examination Vis-à-Vis Its Historical Situatedness and Pedagogical Sensibilities.

Gift Child Q 2017 Oct 31;61(4):343-360. Epub 2017 Jul 31.

University of British Columbia, Vancouver, British Columbia, Canada.

After nearly a century of development, gifted education has evolved into a complex educational discipline with well thought out pedagogy and research agendas. However, while the number of studies escalates, the field as a whole has been criticized for producing fragmented and piecemeal results. One of the reasons for these shortfalls is that the field has invested little in meta-theoretical aspects, such as historical perspectives and philosophical foundations. Read More

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October 2017

A call for improved reporting of human islet characteristics in research articles.

Diabetologia 2018 Dec 14. Epub 2018 Dec 14.

Institute of Cellular Medicine, Faculty of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

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December 2018

Tracking of sport and exercise types from midlife to old age: a 20-year cohort study of British men.

Eur Rev Aging Phys Act 2018 7;15:16. Epub 2018 Dec 7.

1UCL Department of Primary Care & Population Health, UCL Medical School, Royal Free Campus, Rowland Hill Street, London, NW3 2PF UK.

Background: Previous physical activity (PA) tracking studies have examined the stability of overall PA and/or PA types, but few have investigated how specific types of sport/exercise track over the life course. The aim of this study was to determine how specific sports/exercises in midlife track and predict future sport/exercise and PA in men transitioning to old age.

Methods: Seven thousand seven hundred thirty-five men (aged 40-59 years) recruited in 1978-80 were followed up after 12, 16 and 20 years. Read More

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December 2018

Inhaled corticosteroids in COPD: the final verdict is….

Eur Respir J 2018 Dec 13;52(6). Epub 2018 Dec 13.

Centre for Heart Lung Innovation, St Paul's Hospital and Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada.

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December 2018
1 Read

Updated BTS Adult Bronchiectasis Guideline 2018: a multidisciplinary approach to comprehensive care.

Thorax 2019 Jan;74(1):1-3

Host Defence Unit, Division of Respiratory Medicine, Royal Brompton Hospital, London, UK.

The new British Thoracic Society (BTS) Guideline for Bronchiectasis in Adults has been published. This article provides a summary of key highlights of the new BTS Guideline and covers who to investigate, what investigations should be carried out and a management strategy. Read More

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January 2019
1 Read

Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting.

Science 2018 Dec 13. Epub 2018 Dec 13.

Trans-synaptic Signaling Group, European Neuroscience Institute, 37077 Goettingen, Germany.

Forgetting is important. Without it, the relative importance of acquired memories in a changing environment is lost. We discovered that Synaptotagmin-3 (Syt3) localizes to post-synaptic endocytic zones and removes AMPA receptors from synaptic plasma membranes in response to stimulation. Read More

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December 2018
1 Read

Analysis of Trends in Insulin Utilization and Spending Across Canada From 2010 to 2015.

Can J Diabetes 2018 Aug 16. Epub 2018 Aug 16.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada. Electronic address:

Objectives: To describe insulin utilization and spending across Canada and investigate how interprovincial variations in long-acting insulin uptake impact provincial spending.

Methods: We conducted a cross-sectional time-series analysis of insulin products dispensed nationally from January 1, 2010, to December 31, 2015, using data from IQVIA (Durham, North Carolina, United States). Analysis was stratified according to insulin type, payer and province. Read More

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A priori-defined Mediterranean-like dietary pattern predicts cardiovascular events better in north Europe than in Mediterranean countries.

Int J Cardiol 2018 Nov 29. Epub 2018 Nov 29.

Centro Cardiologico Monzino, IRCCS, Milan, Italy; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy.

Background: The Mediterranean Diet (MD) is a model of healthy eating contributing to a favorable health status, but its clinical usefulness is still debated. The aim of this study was to relate the adherence to MD with the incidence of cardio/cerebro-vascular events (VEs) in north and south European participants of the IMPROVE study.

Methods: IMPROVE is an observational, longitudinal, prospective cohort study involving 3703 individuals from five European countries (Finland, Sweden, Netherlands, France and Italy). Read More

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November 2018

Biomimetic regulation of dentine remineralization by amino acid in vitro.

Dent Mater 2018 Dec 10. Epub 2018 Dec 10.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, 237# Luoyu Road, Wuhan 430079, China. Electronic address:

Objective: The aim of this study was to evaluate the effect of conditioning solutions containing DL-aspartic amino (Asp) on dentine remineralization induced by bioactive glass 45S5 (BAG) in a simulated oral environment.

Methods: Sixty dentine discs from human third molars were used. Dentine specimens were treated with ethylene diamine tetraacetic acid (EDTA) to create a partially demineralization model and randomly divided to 4 groups: Artificial saliva (AS) group, Asp group (pretreated with Asp and remineralized with distilled water), BAG group (pretreated with distilled water and remineralized by BAG), Asp-BAG group (pretreated with Asp and remineralized by BAG). Read More

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December 2018

Lower Optimal Treatment Adherence Among Youth Living With HIV in a Universal Health Care Setting Where ART Is Available at No Cost.

J Adolesc Health 2018 Nov 28. Epub 2018 Nov 28.

The British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada; Faculty of Health Sciences, Simon Fraser University, Barnaby, British Columbia, Canada. Electronic address:

Purpose: We assessed differences in optimal adherence between youth (aged 15-29 years) and adults (aged ≥30 years) enrolled in the British Columbia Centre for Excellence in HIV/AIDS Drug Treatment Program from 2010 to 2016.

Methods: Population-level clinical data were used to compare optimal antiretroviral therapy adherence (≥95%), based on pharmacy refill data, among youth and adults. Unadjusted and adjusted generalized estimating estimates were performed to examine the independent relationship between time-dependent age categories and optimal adherence, adjusting for confounders. Read More

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November 2018

Prevention of Arrhythmia Device Infection Trial: The PADIT Trial.

J Am Coll Cardiol 2018 Dec;72(24):3098-3109

Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.

Background: Infection of implanted medical devices has catastrophic consequences. For cardiac rhythm devices, pre-procedural cefazolin is standard prophylaxis but does not protect against methicillin-resistant gram-positive organisms, which are common pathogens in device infections.

Objective: This study tested the clinical effectiveness of incremental perioperative antibiotics to reduce device infection. Read More

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December 2018
16.503 Impact Factor

Chromatin as a Platform for Modulating the Replication Stress Response.

Genes (Basel) 2018 Dec 11;9(12). Epub 2018 Dec 11.

Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada.

Eukaryotic DNA replication occurs in the context of chromatin. Recent years have seen major advances in our understanding of histone supply, histone recycling and nascent histone incorporation during replication. Furthermore, much is now known about the roles of histone remodellers and post-translational modifications in replication. Read More

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December 2018

Effect of Adipose-Derived Stem Cells and Their Exo as Adjunctive Therapy to Nonsurgical Periodontal Treatment: A Histologic and Histomorphometric Study in Rats.

Biomolecules 2018 Dec 10;8(4). Epub 2018 Dec 10.

Professor of Biochemistry, Faculty of Medicine, Cairo University, Cairo 11562, Egypt.

Scaling and root planing (SRP) is of limited value in many cases, so adjunctive treatment was applied to augment its outcome. Adipose-derived stem/stromal cells (ADSCs) were investigated in periodontal regeneration with promising results. However, they have safety concerns. Read More

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December 2018

"The British Soldier is no Bolshevik": The British Army, Discipline, and the Demobilization Strikes of 1919.

Authors:
William Butler

20 Century Br Hist 2018 Dec 13. Epub 2018 Dec 13.

University of Kent, UK.

This article considers the breakdown in discipline in the British Army which occurred in Britain and on the Western Front during the process of demobilization at the end of the First World War. Many soldiers, retained in the army immediately after the Armistice, went on strike, and some formed elected committees, demanding their swifter return to civilian life. Their perception was that the existing demobilization system was unjust, and men were soon organized by those more politically conscious members of the armed forces who had enlisted for the duration of the war. Read More

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December 2018

The contributions of executive functions to mathematical learning difficulties and mathematical talent during adolescence.

PLoS One 2018 13;13(12):e0209267. Epub 2018 Dec 13.

Instituto de Neurociencias, CUCBA, Universidad de Guadalajara, Guadalajara, Jalisco, México.

Are mathematical learning difficulties caused by impairment of the abilities that underlie mathematical talent? Or are mathematical difficulties and talent qualitatively different? The main goal of this study was to determine whether mathematical learning difficulties are explained by the same executive functions as mathematical talent. We screened a pool of 2,682 first-year high school students and selected 48 for evaluation, dividing them into three groups: those with mathematical learning difficulties (n = 16), those with typical performance (n = 16), and those with mathematical talent (n = 16). Adolescents from the learning difficulties and talented groups had age, reading skills, and verbal and non-verbal intelligence that were similar to those of the typical performance group. Read More

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December 2018

Impact of a 3-Day High-Altitude Trek on Xue Mountain (3886 m), Taiwan, on the Emotional States of Children: A Prospective Observational Study.

High Alt Med Biol 2018 Dec 13. Epub 2018 Dec 13.

15 Department of Microbiology and Immunology, University of British Columbia , Vancouver, Canada .

Chao, Chun-Chieh, Lung Hung Chen, Yin-Chou Lin, Shih-Hao Wang, Shih-Hao Wu, Wen-Cheng Li, Kuo-Feng Huang, Te-Fa Chiu, and I-Chih Kuo. Impact of a 3-day high-altitude trek on Xue Mountain (3886 m), Taiwan, on the emotional states of children: A prospective observational study. High Alt Med Biol. Read More

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December 2018

Increased Airway Wall Thickness in Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis.

Ann Am Thorac Soc 2018 Dec 13. Epub 2018 Dec 13.

Brigham and Women\'s Hospital, 1861, Medicine, Boston, Massachusetts, United States ;

Rationale: There is increasing evidence that aberrant processes occurring in the airways may precede the development of idiopathic pulmonary fibrosis (IPF); however, there has been no prior confirmatory data from imaging studies.

Objectives: To assess quantitative measures of airway wall thickness (AWT) in populations characterized for interstitial lung abnormalities (ILA) and for IPF.

Methods: Chest computed tomography scans (CTs) and measures of AWT were available on 6073, 615, 1167, and 38 participants from COPDGene, the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE), the Framingham Heart Study (FHS), and in IPF patients from the Brigham and Women's Hospital Herlihy Registry, respectively. Read More

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December 2018