19,280 results match your criteria British journal of anaesthesia[Journal]


Airway management equipment and practice: time to optimise institutional, team, and personal preparedness.

Br J Anaesth 2020 Jun 17. Epub 2020 Jun 17.

Department of Anaesthesia, Royal United Hospitals Bath NHS Foundation Trust, Bath, UK; Bristol Medical School, University of Bristol, Bristol, UK. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.06.012DOI Listing

Blocking Kv1.3 potassium channels psrevents postoperative neuroinflammation and cognitive decline without impairing wound healing in mice.

Br J Anaesth 2020 Jul 2. Epub 2020 Jul 2.

Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA. Electronic address:

Background: Postoperative cognitive decline (PCD) requires microglial activation. Voltage-gated Kv1.3 potassium channels are involved in microglial activation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.05.018DOI Listing

Death in the ICU from COVID-19: more research on its effects on families needed.

Br J Anaesth 2020 Jun 17. Epub 2020 Jun 17.

Lewisham and Greenwich NHS Trust, Critical Care Department, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.06.018DOI Listing

High-dose versus low-dose tranexamic acid for paediatric craniosynostosis surgery: a double-blind randomised controlled non-inferiority trial.

Br J Anaesth 2020 Jun 30. Epub 2020 Jun 30.

Department of Anaesthesia, IRCCS Istituto Giannina Gaslini, Genoa, Italy.

Background: Tranexamic acid (TXA) reduces blood loss and transfusion in paediatric craniosynostosis surgery. The hypothesis is that low-dose TXA, determined by pharmacokinetic modelling, is non-inferior to high-dose TXA in decreasing blood loss and transfusion in children.

Methods: Children undergoing craniosynostosis surgery were enrolled in a two-centre, prospective, double-blind, randomised, non-inferiority controlled trial to receive high TXA (50 mg kg followed by 5 mg kg h) or low TXA (10 mg kg followed by 5 mg kg h). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.05.054DOI Listing

Effects of anaesthesia method and tourniquet use on recovery following total knee arthroplasty: a randomised controlled study.

Br J Anaesth 2020 Jun 30. Epub 2020 Jun 30.

Department of Anaesthesiology, Intensive Care and Pain Medicine, Peijas Hospital, HUS Helsinki University Hospital, Helsinki, Finland. Electronic address:

Background: We investigated the effects of spinal and general anaesthesia and surgical tourniquet on acute pain and early recovery after total knee arthroplasty (TKA).

Methods: Patients (n=413) were randomised to four parallel groups: spinal anaesthesia with or without tourniquet, and general anaesthesia with or without tourniquet. The primary outcome was patient-controlled i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.03.036DOI Listing

Patient blood management interventions do not lead to important clinical benefits or cost-effectiveness for major surgery: a network meta-analysis.

Br J Anaesth 2020 Jun 30. Epub 2020 Jun 30.

Department of Cardiovascular Sciences and National Institute for Health Research Leicester Biomedical Research Unit in Cardiovascular Medicine, College of Life Sciences, University of Leicester, Leicester, UK.

Background: Patient blood management (PBM) interventions aim to improve clinical outcomes by reducing bleeding and transfusion. We assessed whether existing evidence supports the routine use of combinations of these interventions during and after major surgery.

Methods: Five systematic reviews and a National Institute of Health and Care Excellence health economic review of trials of common PBM interventions enrolling participants of any age undergoing surgery were updated. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.04.087DOI Listing

Application of specific-to-total IgE ratio does not benefit diagnostic performance of serologic testing for rocuronium allergy.

Br J Anaesth 2020 Jun 30. Epub 2020 Jun 30.

Faculty of Medicine and Health Sciences, Department of Immunology, Allergology, Rheumatology and Infla-Med Centre of Excellence, Antwerp, Belgium. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.05.032DOI Listing

Neutrophil extracellular trapping and angiogenesis biomarkers after intravenous or inhalation anaesthesia with or without intravenous lidocaine for breast cancer surgery: a prospective, randomised trial.

Br J Anaesth 2020 Jun 29. Epub 2020 Jun 29.

Department of Histology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Background: Experimental and, retrospective, clinical data indicate that anaesthetic technique might influence the risk of metastasis after cancer surgery. Neutrophil extracellular trapping (NETosis) is an immunological mechanism strongly linked with increased metastatic risk. Similarly, vascular endothelial growth factor A is linked to angiogenesis implicated in recurrence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.05.003DOI Listing

Analysis of practices to promote reproducibility and transparency in anaesthesiology research.

Br J Anaesth 2020 Jun 28. Epub 2020 Jun 28.

Oklahoma State University Center for Health Sciences, Tulsa, OK, USA.

Introduction: Reliable, high-quality research is essential to the field of anaesthesiology. Reproducibility and transparency have been investigated in the biomedical domain and in the social sciences, with both lacking to provide necessary information to reproduce the study findings. In this study, we investigated 14 indicators of reproducibility in anaesthesiology research. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.03.035DOI Listing

Is difficult or failed intubation a confounder or an effect modifier for hypoxaemia? Comment on Br J Anaesth; 125: e81-7.

Authors:
Asish Subedi

Br J Anaesth 2020 Jun 28. Epub 2020 Jun 28.

Dharan, Nepal. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.05.034DOI Listing

Prevalence and intensity of persistent post-surgical pain following breast cancer surgery: a systematic review and meta-analysis of observational studies.

Br J Anaesth 2020 Jun 28. Epub 2020 Jun 28.

Department of Anesthesia, McMaster University, Hamilton, ON, Canada; Michael G. DeGroote Institute for Pain Research and Care, McMaster University, Hamilton, ON, Canada; Michael G. DeGroote Centre for Medicinal Cannabis Research, McMaster University, Hamilton, ON, Canada; Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, ON, Canada.

Background: The prevalence and intensity of persistent post-surgical pain (PPSP) after breast cancer surgery are uncertain. We conducted a systematic review and meta-analysis to further elucidate this issue.

Methods: We searched MEDLINE, Embase, CINAHL, and PsycINFO, from inception to November 2018, for observational studies reporting persistent pain (≥3 months) after breast cancer surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.04.088DOI Listing

Causal inference in perioperative medicine observational research: part 1, a graphical introduction.

Br J Anaesth 2020 Jun 26. Epub 2020 Jun 26.

Critical Care, University College London Hospitals NHS Foundation Trust, London, UK.

Graphical models have emerged as a tool to map out the interplay between multiple measured and unmeasured variables, and can help strengthen the case for a causal association between exposures and outcomes in observational studies. In Part 1 of this methods series, we will introduce the reader to graphical models for causal inference in perioperative medicine, and set the framework for Part 2 of the series involving advanced methods for causal inference. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.03.031DOI Listing

Theory and practical use of Bayesian methods in interpreting clinical trial data: a narrative review.

Br J Anaesth 2020 Jun 26. Epub 2020 Jun 26.

Université de Strasbourg, iCUBE, UMR7357, Illkirch Cedex, France; Public Health Department, GMRC, CHU de Strasbourg, Strasbourg, France.

The critical reading of scientific articles is necessary for the daily practice of evidence-based medicine. Rigorous comprehension of statistical methods is essential, as reflected by the extensive use of statistics in the biomedical literature. In contrast to the customary frequentist approach, which never uses or gives the probability of a hypothesis, Bayesian theory uses probabilities for both hypotheses and data. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.04.092DOI Listing

Perioperative vasoactive drugs in patients undergoing major abdominal surgery. Comment on Br J Anaesth 2020; 124: 513-24.

Authors:
Hiroshi Yonekura

Br J Anaesth 2020 Jun 24. Epub 2020 Jun 24.

Tsu, Mie, Japan. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.05.044DOI Listing

Beyond the operating room: the roles of anaesthesiologists in pandemics.

Br J Anaesth 2020 Jun 11. Epub 2020 Jun 11.

Boston University School of Medicine, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.06.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287450PMC

Perineural dexamethasone attenuates liposomal bupivacaine-induced delayed neural inflammation in mice in vivo.

Br J Anaesth 2020 Jun 24. Epub 2020 Jun 24.

Département d'Anesthésie-Réanimation, Centre Hospitalier Universitaire de Purpan, Toulouse, France; Institut des Maladies Métaboliques et Cardiovasculaires, INSERM U1048, Université Paul Sabatier, Toulouse, France.

Background: Liposomal bupivacaine (Exparel®) is a sustained-release formulation of bupivacaine for use in surgical infiltration anaesthesia. We analysed the histological nerve toxicity and clinical effectiveness of perineural Exparel® alone or with added dexamethasone in a mouse model.

Methods: We assigned 98 mice receiving a perineural sciatic nerve injection into seven groups: sham (n=14, perineural saline), B (n=14, perineural bupivacaine), BDIP (n=14, perineural bupivacaine + intraperitoneal dexamethasone), BDPN (n=14, perineural bupivacaine + perineural dexamethasone), E (n=14, perineural Exparel®), EDIP (n=14, perineural Exparel® + intraperitoneal dexamethasone), and EDPN (n=14, perineural Exparel® + perineural dexamethasone). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.04.091DOI Listing

Time for anaesthetists to take back control of the preoperative fasting message. Comment on Br J Anaesth 2020; 124: 361-3.

Authors:
David Rowe

Br J Anaesth 2020 Jun 23. Epub 2020 Jun 23.

Armidale, NSW, Australia. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.05.024DOI Listing

Should we accept a higher risk of type I errors in some trials?

Authors:
Jens Laigaard

Br J Anaesth 2020 Jun 23. Epub 2020 Jun 23.

Copenhagen, Denmark. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.05.033DOI Listing

Availability of dantrolene for the management of malignant hyperthermia crises: European Malignant Hyperthermia Group guidelines.

Br J Anaesth 2020 Jun 23. Epub 2020 Jun 23.

Department of Anaesthesioloy, University Hospital Basel and University of Basel, Basel, Switzerland.

Faced with a malignant hyperthermia crisis, the immediate access to sufficient dantrolene is essential to achieve the best possible outcome for the patient. However, malignant hyperthermia crises are rare, and there may be administrative pressures to limit the amount of dantrolene stocked or, in some countries, not to stock dantrolene at all. There are no published guidelines to support anaesthetic departments in their effort to ensure availability of sufficient dantrolene for the management of malignant hyperthermia crises. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.04.089DOI Listing

Prone positioning in COVID-19 acute respiratory failure: just do it?

Br J Anaesth 2020 Jun 9. Epub 2020 Jun 9.

Department of Anaesthesia and Intensive Care Medicine, Galway University Hospitals, Galway, Ireland; Anaesthesia and Intensive Care Medicine, School of Medicine, National Unversity of Ireland, Galway, Ireland; Regenerative Medicine Institute at the CURAM Centre for Medical Devices, National University of Ireland, Galway, Ireland. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280095PMC

A consensus checklist to help clinicians interpret clinical trial results analysed by Bayesian methods.

Br J Anaesth 2020 Jun 19. Epub 2020 Jun 19.

Université de Strasbourg, iCUBE, UMR7357, Illkirch Cedex, France; Public Health Department, CHU de Strasbourg, GMRC, Strasbourg, France.

Introduction: In the context of an increasing number of publications of trial data analysed by Bayesian methods, clinicians need support to better understand Bayesian statistical methods. The existing checklists are intended for people who already know these methods. We aimed to establish and validate a checklist that contains a group of items considered crucial in interpreting the results of a phase III RCT analysed with Bayesian methods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.04.093DOI Listing

Cardiopulmonary exercise testing in the COVID-19 endemic phase.

Br J Anaesth 2020 Jun 11. Epub 2020 Jun 11.

Department of Respiratory Medicine, Royal Brompton Hospital, London, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287473PMC

Trends in gabapentinoid prescribing, co-prescribing of opioids and benzodiazepines, and associated deaths in Scotland.

Br J Anaesth 2020 Jun 19. Epub 2020 Jun 19.

Division of Population Health and Genomics, School of Medicine, University of Dundee, Dundee, UK.

Background: Gabapentinoid drugs (gabapentin and pregabalin) are effective in neuropathic pain, which has a prevalence of ∼7%. Concerns about increased prescribing have implications for patient safety, misuse, and diversion. Drug-related deaths (DRDs) have increased and toxicology often implicates gabapentinoids. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.05.017DOI Listing

Persistent pain in intensive care survivors: a systematic review.

Br J Anaesth 2020 Jun 18. Epub 2020 Jun 18.

Department of Anaesthesiology, Tampere University Hospital, Tampere, Finland. Electronic address:

Background: According to earlier studies where the main aim has been quality of life, there is growing evidence of increased levels of persistent pain in survivors of critical illness. The cause of admission and several factors during intensive care may have associated risk factors for pain persistence. This systematic review aims to determine the incidence or prevalence of persistent pain after critical illness and to identify risk factors for it. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.04.084DOI Listing

COVID-19: novel pandemic, novel generation of medical students.

Br J Anaesth 2020 Jun 2. Epub 2020 Jun 2.

Palo Alto, CA, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264032PMC

Systemic haemodynamic, renal perfusion and renal oxygenation responses to changes in inspired oxygen fraction during total intravenous or volatile anaesthesia.

Br J Anaesth 2020 Jun 18. Epub 2020 Jun 18.

Preclinical Critical Care Unit, Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia. Electronic address:

Background: Anaesthesia-induced changes in renal perfusion are dependent on the choice of anaesthetic agent. However, the effects of varying inspired oxygen fraction (FiO) on renal perfusion and oxygenation during TIVA (propofol + fentanyl) or volatile anaesthesia (VA; isoflurane) are unknown.

Methods: In 16 Merino ewes, we surgically implanted a renal artery flow probe and laser-Doppler and oxygen-sensing probes in the renal medulla and cortex. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.03.033DOI Listing

Chronic pain after COVID-19: implications for rehabilitation.

Br J Anaesth 2020 May 31. Epub 2020 May 31.

Division of Population Health & Genomics, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.05.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261464PMC

An ethical algorithm for rationing life-sustaining treatment during the COVID-19 pandemic.

Br J Anaesth 2020 Jun 2. Epub 2020 Jun 2.

Wellcome Centre for Ethics and Humanities and Oxford Uehiro Centre for Practical Ethics, University of Oxford, Oxford, UK; John Radcliffe Hospital, University of Oxford, Oxford, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.05.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264035PMC

Effect of mental rotation skills training on ultrasound-guided regional anaesthesia task performance by novice operators: a rater-blinded, randomised, controlled study.

Br J Anaesth 2020 Jun 16. Epub 2020 Jun 16.

Department of Anaesthesia, Nottingham University Hospitals NHS Trust, Nottingham, UK.

Background: The effect of mental rotation training on ultrasound-guided regional anaesthesia (UGRA) skill acquisition is currently unknown. In this study we aimed to examine whether mental rotation skill training can improve UGRA task performance by novice operators.

Methods: We enrolled 94 volunteers with no prior experience of UGRA in this randomised controlled study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.04.090DOI Listing

Ketamine for neuropathic pain: a tiger that won't bite?

Br J Anaesth 2020 Jun 11. Epub 2020 Jun 11.

Leiden, the Netherlands.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.05.009DOI Listing

Human plasma biomarker responses to inhalational general anaesthesia without surgery.

Br J Anaesth 2020 Jun 11. Epub 2020 Jun 11.

Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Background: Postoperative neurocognitive disorders may arise in part from adverse effects of general anaesthetics on the CNS, especially in older patients or individuals otherwise vulnerable to neurotoxicity because of systemic disease or the presence of pre-existing neuropathology. Previous studies have documented cytokine and injury biomarker responses to surgical procedures that included general anaesthesia, but it is not clear to what degree anaesthetics contribute to these responses.

Methods: We performed a prospective cohort study of 59 healthy volunteers aged 40-80 yr who did not undergo surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bja.2020.04.085DOI Listing