162,863 results match your criteria British Politics[Journal]


Social Capital and Mental Health Among Black and Minority Ethnic Groups in the UK.

J Immigr Minor Health 2020 Jul 4. Epub 2020 Jul 4.

Bamford Centre for Mental Health & Wellbeing, Ulster University, Coleraine, UK.

Black and minority ethnic communities are at higher risk of mental health problems. We explore differences in mental health and the influence of social capital among ethnic minority groups in Great Britain. Cross-sectional linear and logistic regression analysis of data from Wave 6 (2014-2016) of the Understanding Society databases. Read More

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http://dx.doi.org/10.1007/s10903-020-01043-0DOI Listing

The MelFo Study UK: Effects of a Reduced-Frequency, Stage-Adjusted Follow-Up Schedule for Cutaneous Melanoma 1B to 2C Patients After 3-Years.

Ann Surg Oncol 2020 Jul 4. Epub 2020 Jul 4.

Department of Surgical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: Evidence-based guidelines for follow-up treatment of American Joint Committee on Cancer (AJCC) stages 1B to 2C melanoma patients are lacking. The MELanoma FOllow-up study is an international phase 3 randomized trial, and the 3-year interim data were recently reported from the Netherlands. The study was undertaken concurrently with a British cohort for comparison and validation of the Dutch study. Read More

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http://dx.doi.org/10.1245/s10434-020-08758-2DOI Listing

Suspected Sunda clouded leopard (Neofelis diardi) predation attempts on two reintroduced Bornean orangutans (Pongo pygmaeus wurmbii) in Bukit Batikap Protection Forest, Central Kalimantan, Indonesia.

Primates 2020 Jul 4. Epub 2020 Jul 4.

Borneo Orangutan Survival Foundation, Jalan Kumbang No. 31, Bogor, West Java, Indonesia.

In February 2017 and August 2018, respectively, two Bornean orangutans (Pongo pygmaeus wurmbii) reintroduced into the Bukit Batikap Protection Forest in Central Kalimantan were found in weakened physical condition and with deep puncture wounds. The first individual was a sub-adult male, and the second an adult female whose 6- to 8-week-old infant was missing. Both individuals were rescued and transported back to the field base camp for treatment. Read More

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http://dx.doi.org/10.1007/s10329-020-00842-1DOI Listing

Treatment of MOG antibody associated disorders: results of an international survey.

J Neurol 2020 Jul 4. Epub 2020 Jul 4.

Department of Neurology, The Walton Centre NHS Foundation Trust, Liverpool, UK.

Introduction: While monophasic and relapsing forms of myelin oligodendrocyte glycoprotein antibody associated disorders (MOGAD) are increasingly diagnosed world-wide, consensus on management is yet to be developed.

Objective: To survey the current global clinical practice of clinicians treating MOGAD.

Method: Neurologists worldwide with expertise in treating MOGAD participated in an online survey (February-April 2019). Read More

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http://dx.doi.org/10.1007/s00415-020-10026-yDOI Listing

Translating Dysphagia Evidence into Practice While Avoiding Pitfalls: Assessing Bias Risk in Tracheostomy Literature.

Dysphagia 2020 Jul 4. Epub 2020 Jul 4.

School of Audiology and Speech Sciences, University of British Columbia, 2177 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.

Critically ill patients who require a tracheostomy often have dysphagia. Widespread practice guidelines have yet to be developed regarding the acute assessment and management of dysphagia in patients with tracheostomy. In order for clinicians to base their practice on the best available evidence, they must first assess the applicable literature and determine its quality. Read More

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http://dx.doi.org/10.1007/s00455-020-10151-wDOI Listing

Drainage, irrigation and fibrinolytic therapy (DRIFT) for posthaemorrhagic ventricular dilatation: 10-year follow-up of a randomised controlled trial.

Arch Dis Child Fetal Neonatal Ed 2020 Jul 4. Epub 2020 Jul 4.

Neonatal Neurology, Bristol Medical School, Faculty of Health Sciences, University of Bristol, Bristol, UK.

Background: Progressive ventricular dilatation after intraventricular haemorrhage (IVH) in preterm infants has a very high risk of severe disability and death. Drainage, irrigation and fibrinolytic therapy (DRIFT), in a randomised controlled trial (RCT), reduced severe cognitive impairment at 2 years.

Objective: To assess if the cognitive advantage of DRIFT seen at 2 years persisted until school age. Read More

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http://dx.doi.org/10.1136/archdischild-2019-318231DOI Listing

Immediate effects of valgus bracing on knee joint moments during walking in knee-healthy individuals: Potential modifying effects of body height.

Gait Posture 2020 Jun 27;80:383-390. Epub 2020 Jun 27.

Research Health Institute, University of the Sunshine Coast, Sunshine Coast, Australia. Electronic address:

Background: The goal of valgus knee brace treatment is to reduce medial knee joint loading during walking, often indicated by external knee adduction moment (KAM) measures. However, existing healthy-subjects studies have been equivocal in demonstrating KAM reduction with valgus knee bracing.

Research Question: What are the immediate effects of valgus bracing at different tension levels on KAM during walking at a controlled speed and does body height modify the brace-KAM associations?

Methods: Data from 32 knee-healthy participants were analysed in this randomized crossover trial. Read More

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http://dx.doi.org/10.1016/j.gaitpost.2020.06.025DOI Listing

Real-time conflict-based Bayesian Tobit models for safety evaluation of signalized intersections.

Accid Anal Prev 2020 Jul 2;144:105660. Epub 2020 Jul 2.

Department of Civil Engineering, University of British Columbia, 6250 Applied Science Lane, Vancouver, BC, V6T 1Z4, Canada. Electronic address:

The safety of signalized intersections has traditionally been evaluated at an aggregate level by relating historical collision records for several years to the annual traffic volume and the geometric characteristics of the intersection. This is a reactive and macroscopic approach that gives little insight into how important dynamic signal cycle-related variables can affect intersection safety such as the arrival type and the shock wave characteristics. The objective of this study is to develop traffic conflict-based real-time safety models for signalized intersections using several state-of-the-art techniques. Read More

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http://dx.doi.org/10.1016/j.aap.2020.105660DOI Listing

Compromised IGF signaling causes caspase-6 activation in Huntington disease.

Exp Neurol 2020 Jul 2:113396. Epub 2020 Jul 2.

Department of Medical Genetics, Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, 950 West 28th Avenue, Vancouver, BC V5Z 4H4, Canada. Electronic address:

Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by an expansion of a polyglutamine repeat in the huntingtin (HTT) protein. Aberrant activation of caspase-6 and cleavage of mutant HTT generating the toxic N-terminal 586 HTT fragment are important steps in the pathogenesis of HD. Similarly, alterations in the insulin-like growth factor 1 (IGF-1) signaling pathway have been implicated in the disease as a result of decreased plasma IGF-1 levels in HD patients. Read More

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http://dx.doi.org/10.1016/j.expneurol.2020.113396DOI Listing

Effect of holding objects on the occurrence of head impact in falls by older adults: Evidence from real-life falls in long-term care.

J Gerontol A Biol Sci Med Sci 2020 Jul 5. Epub 2020 Jul 5.

Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, British Columbia, Canada.

Background: Falls cause approximately 80% of traumatic brain injuries in older adults, and nearly one-third of falls by residents in long-term care (LTC) result in head impact. Holding objects during falls, such as mobility aids, may affect the ability of LTC residents to avoid head impact by arresting the fall with their upper limbs. We examined the prevalence of holding objects and their effect on risk for head impact during real-life falls in older adults living in LTC. Read More

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http://dx.doi.org/10.1093/gerona/glaa168DOI Listing

Corrigendum to "Evaluation of the Wistar-Kyoto rat model of depression and the role of synaptic plasticity in depression and antidepressant response" [Neurosci. Biobehav. Rev. 105 (2019) 1-23].

Neurosci Biobehav Rev 2020 Jul 1;116:162-163. Epub 2020 Jul 1.

Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada; Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.neubiorev.2020.05.011DOI Listing

A First World War example of forensic archaeology.

Authors:
Victoria Martin

Forensic Sci Int 2020 Jun 26;314:110394. Epub 2020 Jun 26.

Cranfield Forensic Institute, Cranfield University, Shrivenham, Swindon, SN6 8LA, UK. Electronic address:

Between 1919 and 1921, the First World War battlefields of France and Belgium were searched by the British Army for the single graves and small cemeteries containing the bodies of British and Commonwealth soldiers. This process was called "concentration". When found, these graves were exhumed, the bodies within were examined to try and establish or confirm identification, and were subsequently reburied in newly built. Read More

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http://dx.doi.org/10.1016/j.forsciint.2020.110394DOI Listing

Lipid nanoparticle technology for therapeutic gene regulation in the liver.

Adv Drug Deliv Rev 2020 Jul 1. Epub 2020 Jul 1.

Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands.

Hereditary genetic disorders, cancer, and infectious diseases of the liver affect millions of people around the globe and are a major public health burden. Most contemporary treatments offer limited relief as they generally aim to alleviate disease symptoms. Targeting the root cause of diseases originating in the liver by regulating malfunctioning genes with nucleic acid-based drugs s holds great promise as a therapeutic approach. Read More

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http://dx.doi.org/10.1016/j.addr.2020.06.026DOI Listing

Skin sensitization in silico protocol.

Regul Toxicol Pharmacol 2020 Jul 1:104688. Epub 2020 Jul 1.

Leadscope, Inc, 1393 Dublin Rd, Columbus, OH, 43215, USA.

The assessment of skin sensitization has evolved over the past few years to include in vitro assessments of key events along the adverse outcome pathway and opportunistically capitalize on the strengths of in silico methods to support a weight of evidence assessment without conducting a test in animals. While in silico methods vary greatly in their purpose and format; there is a need to standardize the underlying principles on which such models are developed and to make transparent the implications for the uncertainty in the overall assessment. In this contribution, the relationship of skin sensitization relevant effects, mechanisms, and endpoints are built into a hazard assessment framework. Read More

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http://dx.doi.org/10.1016/j.yrtph.2020.104688DOI Listing

Intraoperative extubation post arterial switch operation for transposition of the great arteries with intact ventricular septum: A one-year, single centre experience.

Semin Thorac Cardiovasc Surg 2020 Jul 1. Epub 2020 Jul 1.

Division of Pediatric Cardiovascular & Thoracic Surgery, Department of Surgery, Faculty of Medicine, University of British Columbia, 4480 Oak Street, Vancouver, BC, V6H 3V4, Canada.

We sought to examine the clinical impact of intraoperative extubation (IE) in neonates undergoing the arterial switch operation (ASO) for D-transposition of the great arteries with intact ventricular septum (dTGA/IVS). This was a single centre retrospective study of patients who underwent ASO for dTGA/IVS in the 12 months after an institutional change in practice favouring IE when clinically feasible. A control group was obtained by identifying the same number of consecutive patients with dTGA/IVS who underwent ASO immediately prior to this institutional change in practice, none of whom were extubated intraoperatively. Read More

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http://dx.doi.org/10.1053/j.semtcvs.2020.06.038DOI Listing

Examining Coronary Revascularization Practice Patterns for Diabetics: Perceived Barriers, Facilitators, and Implications for Knowledge Translation.

Can J Cardiol 2019 Nov 27. Epub 2019 Nov 27.

British Columbia Centre for Improved Cardiovascular Health, Vancouver, British Columbia, Canada; Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada.

Background: The FREEDOM trial provided robust evidence that coronary artery bypass grafting (CABG) was superior to percutaneous coronary intervention (PCI) for coronary revascularization in patients with diabetes mellitus (DM) and multivessel coronary artery disease (MV-CAD). The present study examined practice pattern changes and perceived barriers and facilitators to implementing FREEDOM trial evidence in British Columbia (BC).

Methods: Using a population-based database of cardiac procedures in BC, PCI:CABG ratios from 2007-2014 were compared before and after publication of the FREEDOM trial in the 4 tertiary cardiac centres that provided both CABG and PCI. Read More

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http://dx.doi.org/10.1016/j.cjca.2019.11.026DOI Listing
November 2019

Drug-related harm coinciding with income assistance payments: results from a community-based cohort of people who use drugs.

Addiction 2020 Jul 3. Epub 2020 Jul 3.

British Columbia Centre on Substance Use, Vancouver, BC, Canada.

Background And Aims: Income assistance is critical to the health and well-being of socioeconomically marginalized people who use illicit drugs (PWUD). However, past literature paradoxically identifies unintended increases in drug-related harm coinciding with synchronized payments that may magnify signals for drug use. The scope of such harm has not been fully characterized among non-institutionalized populations. Read More

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http://dx.doi.org/10.1111/add.15182DOI Listing

Infection risk of dermatologic therapeutics during the COVID-19 pandemic: an evidence-based recalibration.

Int J Dermatol 2020 Jul 3. Epub 2020 Jul 3.

Division of Dermatology, University of Ottawa, Ottawa, ON, Canada.

Recommendations were made recently to limit or stop the use of oral and systemic immunotherapies for skin diseases due to potential risks to the patients during the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 pandemic. Herein, we attempt to identify potentially safe immunotherapies that may be used in the treatment of cutaneous diseases during the current COVID-19 pandemic. We performed a literature review to approximate the risk of SARS-CoV-2 infection, including available data on the roles of relevant cytokines, cell subsets, and their mediators in eliciting an optimal immune response against respiratory viruses in murine gene deletion models and humans with congenital deficiencies were reviewed for viral infections risk and if possible coronaviruses specifically. Read More

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http://dx.doi.org/10.1111/ijd.15028DOI Listing

Chloroplast DNA analysis of the invasive weed, Himalayan balsam (Impatiens glandulifera), in the British Isles.

Sci Rep 2020 Jul 3;10(1):10966. Epub 2020 Jul 3.

CABI-UK, Bakeham Lane, Egham, Surrey, TW20 9TY, UK.

Impatiens glandulifera or Himalayan balsam (HB), is an invasive alien weed throughout the British Isles (BI). Classical biological control of HB in the BI using a rust fungus from the Himalayan native range was implemented in 2014. However, not all HB populations are susceptible to the two rust strains currently released. Read More

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http://dx.doi.org/10.1038/s41598-020-67871-0DOI Listing

Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol.

Commun Biol 2020 Jul 3;3(1):342. Epub 2020 Jul 3.

IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.

Protein-based affinity reagents (like antibodies or alternative binding scaffolds) offer wide-ranging applications for basic research and therapeutic approaches. However, whereas small chemical molecules efficiently reach intracellular targets, the delivery of macromolecules into the cytosol of cells remains a major challenge; thus cytosolic applications of protein-based reagents are rather limited. Some pathogenic bacteria have evolved a conserved type III secretion system (T3SS) which allows the delivery of effector proteins into eukaryotic cells. Read More

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http://dx.doi.org/10.1038/s42003-020-1072-4DOI Listing

Ambient weathering of magnesium oxide for CO removal from air.

Nat Commun 2020 Jul 3;11(1):3299. Epub 2020 Jul 3.

Department of Chemical Engineering, Clean Energy Conversions Lab, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA, 01609, USA.

To avoid dangerous climate change, new technologies must remove billions of tonnes of CO from the atmosphere every year by mid-century. Here we detail a land-based enhanced weathering cycle utilizing magnesite (MgCO) feedstock to repeatedly capture CO from the atmosphere. In this process, MgCO is calcined, producing caustic magnesia (MgO) and high-purity CO. Read More

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http://dx.doi.org/10.1038/s41467-020-16510-3DOI Listing

Bax and Bak jointly control survival and dampen the early unfolded protein response in pancreatic β-cells under glucolipotoxic stress.

Sci Rep 2020 Jul 3;10(1):10986. Epub 2020 Jul 3.

Diabetes Research Group, BC Children's Hospital Research Institute, Vancouver, BC, Canada.

ER stress and apoptosis contribute to the loss of pancreatic β-cells under pro-diabetic conditions of glucolipotoxicity. Although activation of canonical intrinsic apoptosis is known to require pro-apoptotic Bcl-2 family proteins Bax and Bak, their individual and combined involvement in glucolipotoxic β-cell death are not known. It has also remained an open question if Bax and Bak in β-cells have non-apoptotic roles in mitochondrial function and ER stress signaling, as suggested in other cell types. Read More

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http://dx.doi.org/10.1038/s41598-020-67755-3DOI Listing

π covalency in the halogen bond.

Nat Commun 2020 Jul 3;11(1):3310. Epub 2020 Jul 3.

Department of Chemistry, The University of British Columbia, 2036 Main Mall, Vancouver, BC, V6T 1Z1, Canada.

Halogen bonds are a highly directional class of intermolecular interactions widely employed in chemistry and chemical biology. This linear interaction is commonly viewed to be analogous to the hydrogen bond because hydrogen bonding models also intuitively describe the σ-symmetric component of halogen bonding. The possibility of π-covalency in a halogen bond is not contemplated in any known models. Read More

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http://dx.doi.org/10.1038/s41467-020-17122-7DOI Listing

Climate change glossary for public health practice: from vulnerability to climate justice.

J Epidemiol Community Health 2020 Jul 3. Epub 2020 Jul 3.

Deakin University School of Health and Social Development, Burwood, Australia.

Climate change is an emerging and growing field of practice for the international public health community. As practitioners, researchers and policy-makers grapple with the local health impacts of climate change, there is an increasing need to clarify key terminology to support public health actors engage and respond in ways that promote intersectoral collaboration. This contribution introduces the public health discourse on climate change, with a particular focus on its implications for health equity. Read More

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http://dx.doi.org/10.1136/jech-2020-213889DOI Listing

British Gynaecological Cancer Society (BGCS) vulval cancer guidelines: Recommendations for practice.

Eur J Obstet Gynecol Reprod Biol 2020 Jun 8. Epub 2020 Jun 8.

Gynaecologic Oncology, Imperial College London Faculty of Medicine, London, SW7 2DD, UK.

The purpose of this guideline is to collate evidence and propose evidence-based guidelines for the diagnosis and management of adult patients with vulva carcinoma treated in the UK. Malignant melanoma may present via similar routes and will be discussed. The reader is referred to the Ano-uro-genital Mucosal Melanoma Full Guideline [1] for more detailed recommendations. Read More

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http://dx.doi.org/10.1016/j.ejogrb.2020.05.054DOI Listing

Profiling avidity of antibodies elicited by vaccination using enzyme-linked immunosorbent assay-based elution - Insights into a novel experimental and analytical approach.

Vaccine 2020 Jun 30. Epub 2020 Jun 30.

Vaccine Evaluation Center, BC Children's Hospital, University of British Columbia, Vancouver, Canada; Division of Infectious Diseases, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.vaccine.2020.06.060DOI Listing

Unravelling the mysteries of gout by multimodality imaging.

Semin Arthritis Rheum 2020 Jun;50(3S):S17-S23

Department of Radiology, Department of Emergency and Trauma Radiology, University of British Columbia/ Vancouver General Hospital, 899W 12th Ave, Vancouver, BC V5Z 1M9, Canada. Electronic address:

Gout is a common inflammatory arthritis that manifests as an aggregate of variably symptomatic monosodium urate crystals (MSU) in the joints and surrounding tissues in addition to multisystem involvement such as genitourinary and cardiovascular systems. In recent decades, there has been a documented increase in the prevalence and incidence of gout. Risk factors for gout include obesity, dietary influences, hypertension, renal impairment, and diuretic use. Read More

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http://dx.doi.org/10.1016/j.semarthrit.2020.04.009DOI Listing

A comprehensive insight into the potential roles of VDR gene polymorphism in obesity: a systematic review.

Arch Physiol Biochem 2020 Jul 3:1-13. Epub 2020 Jul 3.

Department of Nutrition, Maragheh University of Medical Sciences, Maragheh, Iran.

Vitamin D receptor (VDR) gene polymorphisms are believed to be involved in the obesity pathogenesis. This study summarises the results of research concerning the association between VDR polymorphisms and obesity. For this survey, the records of common databases were searched until November 2019. Read More

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http://dx.doi.org/10.1080/13813455.2020.1788097DOI Listing

Normative references and clinical correlates of fetal umbilical artery Doppler indices in southwestern Nigeria.

Int J Gynaecol Obstet 2020 Jul 3. Epub 2020 Jul 3.

Department of Radiology, Lagos State University Teaching Hospital, Lagos, Nigeria.

Objective: To derive normative references for umbilical artery (UA) Doppler indices, including pulsatility index (PI), resistance index (RI), and systolic/diastolic (SD) ratio, for singleton pregnancies in Ile-Ife, Nigeria, and compare them with reference values from other populations.

Methods: A longitudinal study involving 415 women with a singleton fetus at 26-40 gestational weeks attending Obafemi Awolowo University Hospital, Ile-Ife, between July 2015 and March 2019. Fetal UA PI, RI, and SD ratio were measured every 4 weeks until delivery. Read More

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http://dx.doi.org/10.1002/ijgo.13294DOI Listing

Isolated limb perfusion for soft tissue sarcoma: Current practices and future directions. A survey of experts and a review of literature.

Cancer Treat Rev 2020 Jun 19;88:102058. Epub 2020 Jun 19.

Sarcoma Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.

Soft tissue sarcomas constitute 1% of adult malignant tumors. They are a heterogeneous group of more than 50 different histologic types. Isolated limb perfusion is an established treatment strategy for locally advanced sarcomas. Read More

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http://dx.doi.org/10.1016/j.ctrv.2020.102058DOI Listing

Investigation of spectroscopic and proteomic alterations underlying prostate carcinogenesis.

J Proteomics 2020 Jun 30:103888. Epub 2020 Jun 30.

iBiMED - Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, Portugal. Electronic address:

Prostate cancer (PCa) treatment remains challenging, especially in advanced stages, where the lack of sensitivity and specificity of available biomarkers makes it difficult to establish an accurate prognosis. Therefore, it is imperative to study PCa biology to identify key molecules that can improve PCa management. In this study, eight prostate tumor tissues and paired normal tissues were analyzed using two approaches-Fourier-transform infrared (FT-IR) spectroscopy for spectroscopic profiling of biomolecules and antibody microarray for signaling proteins-with the main goal of identifying metabolic and proteomic changes that enable the distinction between normal and tumor conditions. Read More

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http://dx.doi.org/10.1016/j.jprot.2020.103888DOI Listing

Is it always possible to complete a systematic review in 2 weeks? Further thoughts and considerations.

J Clin Epidemiol 2020 Jun 30. Epub 2020 Jun 30.

Pharmalytics Group, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.jclinepi.2020.06.034DOI Listing

External Validation Demonstrated The Ottawa SAH Prediction Models Can Identify pSAH Using Health Administrative Data.

J Clin Epidemiol 2020 Jun 30. Epub 2020 Jun 30.

Department of Medicine (Clinical Epidemiology), uOttawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute; ICES-uOttawa, Administrative Services, 1053 Carling Ave Building, 1st Floor, Ottawa, ON K1Y 4E9.

Objective: To externally validate 3 pSAH identification models.

Study Design And Setting: We evaluated 3 models that identify pSAH using recursive partitioning (A), logistic regression (B), and a prevalence adjusted logistic regression(C), respectively. Blinded chart review and/or linkage to existing registries determined pSAH status. Read More

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http://dx.doi.org/10.1016/j.jclinepi.2020.06.024DOI Listing

Wave-like Patterns of Plant Phenology Determine Ungulate Movement Tactics.

Curr Biol 2020 Jun 26. Epub 2020 Jun 26.

US Geological Survey, Wyoming Cooperative Fish and Wildlife Research Unit, Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071, USA.

Animals exhibit a diversity of movement tactics [1]. Tracking resources that change across space and time is predicted to be a fundamental driver of animal movement [2]. For example, some migratory ungulates (i. Read More

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http://dx.doi.org/10.1016/j.cub.2020.06.032DOI Listing

Continent-wide Shifts in Song Dialects of White-Throated Sparrows.

Curr Biol 2020 Jun 30. Epub 2020 Jun 30.

Department of Biology, Wilfrid Laurier University, Waterloo, ON N2L 3C5, Canada.

Hypotheses on regional song variation ("dialects") assume that dialects remain stable within regions, are distinct between regions, and persist within populations over extensive periods [1-3]. Theories to explain dialects focus on mechanisms that promote persistence of regional song variants despite gene flow between regions [4-6], such as juveniles settling in non-natal populations retaining only those songs from their repertoires that match neighbors [7, 8]. It would be considered atypical for a novel song variant to invade and replace the established regional variant. Read More

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http://dx.doi.org/10.1016/j.cub.2020.05.084DOI Listing

SLC44A2 - A novel therapeutic target for venous thrombosis?

J Thromb Haemost 2020 Jul;18(7):1556-1558

Department of Immunology & Inflammation, Imperial College London, London, UK.

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http://dx.doi.org/10.1111/jth.14834DOI Listing

Making Sense of the Hands and Mouth: The Role of "Secondary" Cues to Meaning in British Sign Language and English.

Cogn Sci 2020 Jul;44(7):e12868

Division of Psychology and Language Sciences, University College London.

Successful face-to-face communication involves multiple channels, notably hand gestures in addition to speech for spoken language, and mouth patterns in addition to manual signs for sign language. In four experiments, we assess the extent to which comprehenders of British Sign Language (BSL) and English rely, respectively, on cues from the hands and the mouth in accessing meaning. We created congruent and incongruent combinations of BSL manual signs and mouthings and English speech and gesture by video manipulation and asked participants to carry out a picture-matching task. Read More

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http://dx.doi.org/10.1111/cogs.12868DOI Listing

Monte Carlo simulation of uncertainty to identify barriers to optimizing blood pressure control.

J Hypertens 2020 Jun 29. Epub 2020 Jun 29.

King's College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences.

Objectives: To assess the impact of variable drug response and measurement error on SBP control.

Methods: We simulated a treat-to-target strategy for populations with different pretreatment SBP, whereby medications were added sequentially until measured SBP (mSBP) less than 140 mmHg. Monte Carlo simulations determined variability of both drug response (drugeff ± σdrug; 10 ± 5 mmHg base case) and measurement error (σmeas; 10 mmHg base case) of true SBP (tSBP). Read More

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http://dx.doi.org/10.1097/HJH.0000000000002546DOI Listing

The role of FLIR ONE ® thermography in complex regional pain syndrome: A case series.

Am J Phys Med Rehabil 2020 Jul 1. Epub 2020 Jul 1.

University of British Columbia, Division of Physical Medicine and Rehabilitation, Department of Medicine, Victoria, BC, Canada.

Complex regional pain syndrome (CRPS) remains a debated syndrome characterized by symptoms and signs, including pain, sensory disturbances, thermal asymmetry, edema, and motor impairments. Thermography is a tool that assesses skin surface temperature distribution. Current literature appears to support the role of thermography for diagnostic purposes, however its role in monitoring the response to treatment in CRPS is unclear. Read More

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http://dx.doi.org/10.1097/PHM.0000000000001522DOI Listing

Professional Identity Formation: A Role for Patients as Mentors.

Acad Med 2020 Jun 30. Epub 2020 Jun 30.

C.C. Kline is research coordinator, Patient and Community Partnership for Education, University of British Columbia, Vancouver, British Columbia, Canada; ORCID: https://orcid.org/0000-0003-2254-0721. S. Park is a family medicine resident, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; ORCID: https://orcid.org/0000-0002-0088-8527. W.J. Godolphin is professor emeritus, Department of Pathology and Laboratory Medicine, Faculty of Medicine, and codirector, Patient and Community Partnership for Education, University of British Columbia, Vancouver, British Columbia, Canada; ORCID: https://orcid.org/0000-0003-0113-1339. A. Towle is associate professor, Department of Medicine, Faculty of Medicine, and co-director, Patient and Community Partnership for Education, University of British Columbia, Vancouver, British Columbia, Canada; ORCID: https://orcid.org/0000-0002-7164-0959.

Purpose: Medical education should foster professional identity formation, but there is much to be learned about how to support learners to develop their professional identity. This study examined the role that patients can play in supporting professional identity development during the University of British Columbia Interprofessional Health Mentors Program (HMP), a longitudinal preclinical elective in which patients, or their caregivers, act as mentors and educate students about their lived experience of a chronic condition or disability.

Method: The authors interviewed 18 medical residents in 2016, 3 to 4 years after they completed the HMP. Read More

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http://dx.doi.org/10.1097/ACM.0000000000003561DOI Listing

Exploring the Contributions of Combined Model Regional Medical Education Campuses to the Physician Workforce.

Acad Med 2020 Jun 30. Epub 2020 Jun 30.

J. Bates was professor emerita, Department of Family Practice, University of British Columbia, Vancouver, British Columbia, Canada, at the time this work was done. ORCID: http://orcid.org/0000-0001-6940-2946. P. Grand'Maison is professor, Departments of Family Medicine and Emergency Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada. S.R. Banner was CEO, Canadian Resident Matching Service, from 1986-2016, and is Director of Admissions for Canada, St. George's Medical School, Ottawa, Ontario, Canada. C.Y. Lovato is professor, School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. K.W. Eva is professor and director of education research and scholarship, Department of Medicine, and associate director and senior scientist, Centre for Health Education Scholarship, University of British Columbia, Vancouver, British Columbia, Canada. ORCID: http://orcid.org/0000-0002-8672-2500.

Purpose: Physician shortages and maldistribution, particularly within family medicine, have led many medical schools worldwide to create regional medical campuses (RMCs) for clerkship training. However, Canadian medical schools have developed a number of RMCs in which all years of training (i.e. Read More

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http://dx.doi.org/10.1097/ACM.0000000000003560DOI Listing

Effects of a 12-Week Multifaceted Wearable-Based Program for People With Knee Osteoarthritis: Randomized Controlled Trial.

JMIR Mhealth Uhealth 2020 Jul 3;8(7):e19116. Epub 2020 Jul 3.

Arthritis Research Canada, Richmond, BC, Canada.

Background: Current guidelines emphasize an active lifestyle in the management of knee osteoarthritis (OA), but up to 90% of patients with OA are inactive. In a previous study, we demonstrated that an 8-week physiotherapist (PT)-led counseling intervention, with the use of a Fitbit, improved step count and quality of life in patients with knee OA, compared with a control.

Objective: This study aimed to examine the effect of a 12-week, multifaceted wearable-based program on physical activity and patient outcomes in patients with knee OA. Read More

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http://dx.doi.org/10.2196/19116DOI Listing

CAEP Joint Position Statement - Management of devastating brain injuries in the emergency department: Enhancing neuroprognostication and maintaining the opportunity for organ and tissue donation.

CJEM 2020 Jun 19:1-3. Epub 2020 Jun 19.

Division of Critical Care, Montreal Children's Hospital, McGill University Health Centre, Montreal, QC.

The primary purpose of this statement is to improve neuroprognostication after devastating brain injury (DBI), with a secondary benefit of potential organ and tissue donation. Read More

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http://dx.doi.org/10.1017/cem.2020.357DOI Listing

Dilated Cardiomyopathy Mutations in Thin Filament Regulatory Proteins Reduce Contractility, Suppress Systolic Ca & Activate NFAT & AKT Signalling.

Am J Physiol Heart Circ Physiol 2020 Jul 3. Epub 2020 Jul 3.

Radcliffe Department of Medicine (Division of Cardiovascular Medicine), University of Oxford, United Kingdom.

Dilated cardiomyopathy (DCM) is clinically characterised by dilated ventricular cavities and reduced ejection fraction, leading to heart failure and increased thromboembolic risk. Mutations in thin filament regulatory proteins can cause DCM and have been shown in vitro to reduce contractility and myofilament Ca-affinity. In this work we have studied the functional consequences of mutations in cardiac troponin T (R131W), cardiac troponin I (K36Q) and α-tropomyosin (E40K) using adenovirally transduced isolated guinea pig left ventricular cardiomyocytes. Read More

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http://dx.doi.org/10.1152/ajpheart.00272.2020DOI Listing

Alterations in resting cerebrovasscular regulation do not affect reactivity to hypoxia, hyperoxia, or neurovascular coupling following a SCUBA dive.

Exp Physiol 2020 Jul 3. Epub 2020 Jul 3.

Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Okanagan, Kelowna, Canada.

New Findings: What is the central question of this study? To characterize cerebral blood flow (CBF) regulation following a single SCUBA dive to a depth of 18 m sea water with a 47-minute bottom time. What is the main finding and its importance? Acute alterations in CBF regulation at rest, including; extra-cranial vasodilation, reductions in shear patterns, and elevations in intra-cranial blood velocity were observed at rest following a single SCUBA dive. These subtle changes in CBF regulation did not translate into any functional changes in cerebrovascular reactivity to hypoxia or hyperoxia, or neurovascular coupling following a single SCUBA dive. Read More

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http://dx.doi.org/10.1113/EP088746DOI Listing

Disease Activity in Inflammatory Bowel Disease Is Associated With Arterial Vascular Disease.

Inflamm Bowel Dis 2020 Jul 3. Epub 2020 Jul 3.

Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK.

Background And Aims: There is evidence that several inflammatory diseases are associated with increased cardiovascular risk. Whether this is true for inflammatory bowel diseases remains controversial. We aimed to assess this risk, corrected for the effects of conventional vascular risk factors and IBD disease activity. Read More

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http://dx.doi.org/10.1093/ibd/izaa156DOI Listing

Little Doubt That CBT Works for Pediatric OCD.

J Am Acad Child Adolesc Psychiatry 2020 Jul 25;59(7):785-787. Epub 2020 Jun 25.

Baylor College of Medicine, Houston, Texas.

We write with great concern in response to the recent systematic review and meta-analysis of cognitive-behavioral therapy (CBT) in pediatric obsessive-compulsive disorder (OCD) by Uhre et al. Although the authors' results consistently support the clinical efficacy of CBT for pediatric OCD, we expect that, much like ourselves, readers will be confused by the discordant and inappropriate conclusions that they put forward. These conclusions stem from the authors' application and interpretation of their particular qualitative methods, which could lead important stakeholders (eg, parents, patients, clinicians, and payers) to wrongly discount clear evidence for what is known to be the best evidence-based therapy for pediatric OCD. Read More

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http://dx.doi.org/10.1016/j.jaac.2020.01.026DOI Listing

Optimal cut-off points for waist circumference in the definition of metabolic syndrome in Chile.

Public Health Nutr 2020 Jul 3:1-6. Epub 2020 Jul 3.

Department of European and Mediterranean Cultures: Architecture, Environment and Cultural Heritage (DICEM), University of Basilicata, Matera, Italy.

Objective: To identify sex-specific cut-off points for waist circumference (WC) in the definition of metabolic syndrome (MetS) for the Chilean adult population.

Design: MetS was defined as the presence of at least two out of four of the following criteria: TAG ≥1·7 mmol/l; HDL-cholesterol: <1·3 mmol/l in women and <1·0 mmol/l in men; systolic blood pressure ≥130 mmHg and/or diastolic blood pressure ≥85 mmHg; and fasting glucose ≥ 5·6 mmol/l or current treatment for diabetes. The receiver operating characteristics curve and the AUC were computed to derive the specificity and sensitivity using bootstrapping (10 000 iterations restricted to have at least between 40 and 60 % of the original population). Read More

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http://dx.doi.org/10.1017/S1368980020001469DOI Listing

LncRNA promotes taxane resistance in castration-resistant prostate cancer via a BCL2A1-dependent mechanism.

Epigenomics 2020 Jul 3. Epub 2020 Jul 3.

School of Life, Health & Chemical Sciences, The Open University, Walton Hall, Milton Keynes, Buckinghamshire, MK7 6AA, UK.

Castration-resistant prostate cancer (CRPC) is an incurable malignancy. Long noncoding RNAs (lncRNAs) play key roles in drug resistance. LncRNA role in cabazitaxel resistance (i. Read More

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http://dx.doi.org/10.2217/epi-2019-0316DOI Listing