143,348 results match your criteria British Journal of Renal Medicine[Journal]


A call for improved reporting of human islet characteristics in research articles.

Diabetologia 2018 Dec 14. Epub 2018 Dec 14.

Institute of Cellular Medicine, Faculty of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.

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December 2018

Tracking of sport and exercise types from midlife to old age: a 20-year cohort study of British men.

Eur Rev Aging Phys Act 2018 7;15:16. Epub 2018 Dec 7.

1UCL Department of Primary Care & Population Health, UCL Medical School, Royal Free Campus, Rowland Hill Street, London, NW3 2PF UK.

Background: Previous physical activity (PA) tracking studies have examined the stability of overall PA and/or PA types, but few have investigated how specific types of sport/exercise track over the life course. The aim of this study was to determine how specific sports/exercises in midlife track and predict future sport/exercise and PA in men transitioning to old age.

Methods: Seven thousand seven hundred thirty-five men (aged 40-59 years) recruited in 1978-80 were followed up after 12, 16 and 20 years. Read More

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December 2018

Inhaled corticosteroids in COPD: the final verdict is….

Eur Respir J 2018 Dec 13;52(6). Epub 2018 Dec 13.

Centre for Heart Lung Innovation, St Paul's Hospital and Division of Respiratory Medicine, University of British Columbia, Vancouver, BC, Canada.

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December 2018

Updated BTS Adult Bronchiectasis Guideline 2018: a multidisciplinary approach to comprehensive care.

Thorax 2019 Jan;74(1):1-3

Host Defence Unit, Division of Respiratory Medicine, Royal Brompton Hospital, London, UK.

The new British Thoracic Society (BTS) Guideline for Bronchiectasis in Adults has been published. This article provides a summary of key highlights of the new BTS Guideline and covers who to investigate, what investigations should be carried out and a management strategy. Read More

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January 2019

Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting.

Science 2018 Dec 13. Epub 2018 Dec 13.

Trans-synaptic Signaling Group, European Neuroscience Institute, 37077 Goettingen, Germany.

Forgetting is important. Without it, the relative importance of acquired memories in a changing environment is lost. We discovered that Synaptotagmin-3 (Syt3) localizes to post-synaptic endocytic zones and removes AMPA receptors from synaptic plasma membranes in response to stimulation. Read More

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December 2018
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Analysis of Trends in Insulin Utilization and Spending Across Canada From 2010 to 2015.

Can J Diabetes 2018 Aug 16. Epub 2018 Aug 16.

Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada. Electronic address:

Objectives: To describe insulin utilization and spending across Canada and investigate how interprovincial variations in long-acting insulin uptake impact provincial spending.

Methods: We conducted a cross-sectional time-series analysis of insulin products dispensed nationally from January 1, 2010, to December 31, 2015, using data from IQVIA (Durham, North Carolina, United States). Analysis was stratified according to insulin type, payer and province. Read More

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A priori-defined Mediterranean-like dietary pattern predicts cardiovascular events better in north Europe than in Mediterranean countries.

Int J Cardiol 2018 Nov 29. Epub 2018 Nov 29.

Centro Cardiologico Monzino, IRCCS, Milan, Italy; Dipartimento di Scienze Farmacologiche e Biomolecolari, Università di Milano, Milan, Italy.

Background: The Mediterranean Diet (MD) is a model of healthy eating contributing to a favorable health status, but its clinical usefulness is still debated. The aim of this study was to relate the adherence to MD with the incidence of cardio/cerebro-vascular events (VEs) in north and south European participants of the IMPROVE study.

Methods: IMPROVE is an observational, longitudinal, prospective cohort study involving 3703 individuals from five European countries (Finland, Sweden, Netherlands, France and Italy). Read More

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November 2018

Biomimetic regulation of dentine remineralization by amino acid in vitro.

Dent Mater 2018 Dec 10. Epub 2018 Dec 10.

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, 237# Luoyu Road, Wuhan 430079, China. Electronic address:

Objective: The aim of this study was to evaluate the effect of conditioning solutions containing DL-aspartic amino (Asp) on dentine remineralization induced by bioactive glass 45S5 (BAG) in a simulated oral environment.

Methods: Sixty dentine discs from human third molars were used. Dentine specimens were treated with ethylene diamine tetraacetic acid (EDTA) to create a partially demineralization model and randomly divided to 4 groups: Artificial saliva (AS) group, Asp group (pretreated with Asp and remineralized with distilled water), BAG group (pretreated with distilled water and remineralized by BAG), Asp-BAG group (pretreated with Asp and remineralized by BAG). Read More

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December 2018

Lower Optimal Treatment Adherence Among Youth Living With HIV in a Universal Health Care Setting Where ART Is Available at No Cost.

J Adolesc Health 2018 Nov 28. Epub 2018 Nov 28.

The British Columbia Centre for Excellence in HIV/AIDS, Vancouver, British Columbia, Canada; Faculty of Health Sciences, Simon Fraser University, Barnaby, British Columbia, Canada. Electronic address:

Purpose: We assessed differences in optimal adherence between youth (aged 15-29 years) and adults (aged ≥30 years) enrolled in the British Columbia Centre for Excellence in HIV/AIDS Drug Treatment Program from 2010 to 2016.

Methods: Population-level clinical data were used to compare optimal antiretroviral therapy adherence (≥95%), based on pharmacy refill data, among youth and adults. Unadjusted and adjusted generalized estimating estimates were performed to examine the independent relationship between time-dependent age categories and optimal adherence, adjusting for confounders. Read More

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November 2018

Prevention of Arrhythmia Device Infection Trial: The PADIT Trial.

J Am Coll Cardiol 2018 Dec;72(24):3098-3109

Population Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.

Background: Infection of implanted medical devices has catastrophic consequences. For cardiac rhythm devices, pre-procedural cefazolin is standard prophylaxis but does not protect against methicillin-resistant gram-positive organisms, which are common pathogens in device infections.

Objective: This study tested the clinical effectiveness of incremental perioperative antibiotics to reduce device infection. Read More

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December 2018

Chromatin as a Platform for Modulating the Replication Stress Response.

Genes (Basel) 2018 Dec 11;9(12). Epub 2018 Dec 11.

Terry Fox Laboratory, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada.

Eukaryotic DNA replication occurs in the context of chromatin. Recent years have seen major advances in our understanding of histone supply, histone recycling and nascent histone incorporation during replication. Furthermore, much is now known about the roles of histone remodellers and post-translational modifications in replication. Read More

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December 2018

Effect of Adipose-Derived Stem Cells and Their Exo as Adjunctive Therapy to Nonsurgical Periodontal Treatment: A Histologic and Histomorphometric Study in Rats.

Biomolecules 2018 Dec 10;8(4). Epub 2018 Dec 10.

Professor of Biochemistry, Faculty of Medicine, Cairo University, Cairo 11562, Egypt.

Scaling and root planing (SRP) is of limited value in many cases, so adjunctive treatment was applied to augment its outcome. Adipose-derived stem/stromal cells (ADSCs) were investigated in periodontal regeneration with promising results. However, they have safety concerns. Read More

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December 2018

"The British Soldier is no Bolshevik": The British Army, Discipline, and the Demobilization Strikes of 1919.

Authors:
William Butler

20 Century Br Hist 2018 Dec 13. Epub 2018 Dec 13.

University of Kent, UK.

This article considers the breakdown in discipline in the British Army which occurred in Britain and on the Western Front during the process of demobilization at the end of the First World War. Many soldiers, retained in the army immediately after the Armistice, went on strike, and some formed elected committees, demanding their swifter return to civilian life. Their perception was that the existing demobilization system was unjust, and men were soon organized by those more politically conscious members of the armed forces who had enlisted for the duration of the war. Read More

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December 2018

The contributions of executive functions to mathematical learning difficulties and mathematical talent during adolescence.

PLoS One 2018 13;13(12):e0209267. Epub 2018 Dec 13.

Instituto de Neurociencias, CUCBA, Universidad de Guadalajara, Guadalajara, Jalisco, México.

Are mathematical learning difficulties caused by impairment of the abilities that underlie mathematical talent? Or are mathematical difficulties and talent qualitatively different? The main goal of this study was to determine whether mathematical learning difficulties are explained by the same executive functions as mathematical talent. We screened a pool of 2,682 first-year high school students and selected 48 for evaluation, dividing them into three groups: those with mathematical learning difficulties (n = 16), those with typical performance (n = 16), and those with mathematical talent (n = 16). Adolescents from the learning difficulties and talented groups had age, reading skills, and verbal and non-verbal intelligence that were similar to those of the typical performance group. Read More

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December 2018

Impact of a 3-Day High-Altitude Trek on Xue Mountain (3886 m), Taiwan, on the Emotional States of Children: A Prospective Observational Study.

High Alt Med Biol 2018 Dec 13. Epub 2018 Dec 13.

15 Department of Microbiology and Immunology, University of British Columbia , Vancouver, Canada .

Chao, Chun-Chieh, Lung Hung Chen, Yin-Chou Lin, Shih-Hao Wang, Shih-Hao Wu, Wen-Cheng Li, Kuo-Feng Huang, Te-Fa Chiu, and I-Chih Kuo. Impact of a 3-day high-altitude trek on Xue Mountain (3886 m), Taiwan, on the emotional states of children: A prospective observational study. High Alt Med Biol. Read More

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December 2018

Increased Airway Wall Thickness in Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis.

Ann Am Thorac Soc 2018 Dec 13. Epub 2018 Dec 13.

Brigham and Women\'s Hospital, 1861, Medicine, Boston, Massachusetts, United States ;

Rationale: There is increasing evidence that aberrant processes occurring in the airways may precede the development of idiopathic pulmonary fibrosis (IPF); however, there has been no prior confirmatory data from imaging studies.

Objectives: To assess quantitative measures of airway wall thickness (AWT) in populations characterized for interstitial lung abnormalities (ILA) and for IPF.

Methods: Chest computed tomography scans (CTs) and measures of AWT were available on 6073, 615, 1167, and 38 participants from COPDGene, the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE), the Framingham Heart Study (FHS), and in IPF patients from the Brigham and Women's Hospital Herlihy Registry, respectively. Read More

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December 2018

A novel cell-based β-secretase enzymatic assay for Alzheimer's Disease.

Curr Alzheimer Res 2018 Dec 12. Epub 2018 Dec 12.

Townsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3. Canada.

Background: Deposition of the amyloid β protein (Aβ) into neuritic plaques is the neuropathological hallmark of Alzheimer's Disease (AD). Aβ is generated through the cleavage of the Amyloid Precursor Protein (APP) by β-secretase and γ-secretase. Currently, the evaluation of APP cleavage by β-secretase in experimental settings has largely depended on models that do not replicate the physiological conditions of this process. Read More

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December 2018

Mesencephalic astrocyte-derived neurotropic factor is an important factor in chondrocyte ER homeostasis.

Cell Stress Chaperones 2018 Dec 12. Epub 2018 Dec 12.

Institute of Genetic Medicine, International Centre for Life, Newcastle University, Newcastle Upon Tyne, NE1 3BZ, UK.

Mesencephalic astrocyte-derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER) resident protein that can be secreted due to an imperfect KDEL motif. MANF plays a cytoprotective role in several soft tissues and is upregulated in conditions resulting from intracellular retention of mutant protein, including two skeletal diseases, metaphyseal chondrodysplasia, Schmid type (MCDS) and multiple epiphyseal dysplasia (MED). The role of MANF in skeletal tissue homeostasis is currently unknown. Read More

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December 2018

Subgingival lipid A profile and endotoxin activity in periodontal health and disease.

Clin Oral Investig 2018 Dec 12. Epub 2018 Dec 12.

Faculty of Medicine and Dentistry, University of Plymouth, Plymouth, PL4 8AA, UK.

Objectives: Regulation of lipopolysaccharide (LPS) chemical composition, particularly its lipid A domain, is an important, naturally occurring mechanism that drives bacteria-host immune system interactions into either a symbiotic or pathogenic relationship. Members of the subgingival oral microbiota can critically modulate host immuno-inflammatory responses by synthesizing different LPS isoforms. The objectives of this study were to analyze subgingival lipid A profiles and endotoxin activities in periodontal health and disease and to evaluate the use of the recombinant factor C assay as a new, lipid A-based biosensor for personalized, point-of-care periodontal therapy. Read More

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December 2018

Management of endometrial, ovarian and cervical cancer in the elderly: current approach to a challenging condition.

Arch Gynecol Obstet 2018 Dec 12. Epub 2018 Dec 12.

Unit of Gynecology and Obstetrics, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Via Consolare Valeria 1, 98125, Messina, Italy.

Purpose: Gynaecological cancer management in older people represents a current challenge. Therefore, in the present paper, we aimed to gather all the evidence reported in the literature concerning gynecological cancers in the elderly, illustrating the state of art and the future perspectives.

Methods: We searched MEDLINE (PubMed), EMBASE, Cochrane Central Register of Controlled Trials, IBECS, BIOSIS, Web of Science, SCOPUS and Grey literature (Google Scholar; British Library) from January 1952 to May 2017, using the terms "ovarian cancer", "endometrial cancer", "cervical cancer", "gynecological cancers" combined with 'elderly', 'cancer', 'clinical trial' and 'geriatric assessment'. Read More

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December 2018

Self-face and self-body advantages in congenital prosopagnosia: evidence for a common mechanism.

Exp Brain Res 2018 Dec 12. Epub 2018 Dec 12.

NeuroMI-Milan Center for Neuroscience, Milano, Italy.

Prosopagnosia is a disorder leading to difficulties in recognizing faces. However, recent evidence suggests that individuals with congenital prosopagnosia can achieve considerable accuracy when they have to recognize their own faces (self-face advantage). Yet, whether this advantage is face-specific or not is still unclear. Read More

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December 2018

Transfusion-associated graft-versus-host disease: A concise review.

Authors:
Palma Manduzio

Hematol Rep 2018 Nov 6;10(4):7724. Epub 2018 Nov 6.

Diagnostic Department, Clinical Pathology, 'Augusto Murri' Civil Hospital of Fermo, Italy.

Transfusion-associated graft-versushost disease (TA-GVHD) represents a rare fatal event observed in immunocompromised patients and immunocompetent individuals. The main clinical features of this transfusion reaction are pancitopenia and multiorgan failure (skin, liver, gut). The possible pathogenesis includes donor T lymphocyte proliferation in blood, their engraftment and host tissue attack. Read More

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November 2018

Atypical cerebral palsy: genomics analysis enables precision medicine.

Genet Med 2018 Dec 13. Epub 2018 Dec 13.

BC Children's Hospital Research Institute, Vancouver, BC, Canada.

Purpose: The presentation and etiology of cerebral palsy (CP) are heterogeneous. Diagnostic evaluation can be a prolonged and expensive process that might remain inconclusive. This study aimed to determine the diagnostic yield and impact on management of next-generation sequencing (NGS) in 50 individuals with atypical CP (ACP). Read More

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December 2018
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Comment on: A British Ophthalmic Surveillance Unit (BOSU) study into dysthyroid optic neuropathy in the United Kingdom.

Eye (Lond) 2018 Dec 12. Epub 2018 Dec 12.

Thyroid Eye Disease Service, Department of Ophthalmology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

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December 2018

Strawberry mottle virus (family , order ) encodes a novel glutamic protease to process the RNA2 polyprotein at two cleavage sites.

J Virol 2018 Dec 12. Epub 2018 Dec 12.

Agriculture and Agri-Food Canada, Summerland Research and Development Centre, Summerland, BC, V0H 1Z0, Canada

(SMoV) belongs to the family (order ) and has a bipartite genome with each RNA encoding one polyprotein. All characterized secovirids encode a single protease related to the picornavirus 3C-protease. The SMoV 3C-like protease was previously shown to cut the RNA2 polyprotein (P2) at a single site between the predicted movement protein and coat protein (CP) domains. Read More

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December 2018

Biomarkers for Programmed Death-1 Inhibition in Prostate Cancer.

Oncologist 2018 Dec 12. Epub 2018 Dec 12.

Tulane University School of Medicine, New Orleans, Louisiana, USA

Prostate cancer is the second leading cause of cancer death in American men. Despite the common nature of this disease, there is a poor understanding of biomarkers that predict responsiveness to immunotherapeutic agents such as the programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) inhibitors. Herein we describe a case of complete remission with pembrolizumab therapy in a metastatic castrate-resistant prostate cancer patient with a complex germline alteration (Boland inversion) in association with a tumor demonstrating high microsatellite instability. Read More

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December 2018

Women's occupational exposure to polycyclic aromatic hydrocarbons and risk of breast cancer.

Occup Environ Med 2019 Jan;76(1):22-29

Population Oncology, BC Cancer, Vancouver, British Columbia, Canada.

Objective: To estimate the association between occupational polycyclic aromatic hydrocarbon (PAH) exposure and female breast cancer.

Methods: Lifetime work histories for 1130 cases and 1169 controls from British Columbia and Ontario (Canada) were assessed for PAH exposure using a job-exposure matrix based on compliance measurements obtained during US Occupational Safety and Health Administration workplace safety inspections.

Results: Exposure to any level of PAHs was associated with an increased risk of breast cancer (OR=1. Read More

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January 2019

In house virtual surgery and 3D complex head and neck reconstruction.

J Otolaryngol Head Neck Surg 2018 Dec 12;47(1):75. Epub 2018 Dec 12.

Division of Otolaryngology, Head & Neck Surgery, University of British Columbia, 2775 Laurel Street, DHCC 4th. Floor, Vancouver, BC, V5Z 1M9, Canada.

Background: 3-Dimensional (3D) printing can be applied to virtual planning and creation of surgical guides for mandibular reconstruction. Such systems are becoming increasingly prevalent in head and neck reconstruction. However, third party access to this technology is costly and removes the opportunity to design, create, and modify the bony reconstructions, as third party technology is a black box. Read More

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December 2018

The pulmonary and autonomic effects of high-intensity and low-intensity exercise in diesel exhaust.

Environ Health 2018 12 13;17(1):87. Epub 2018 Dec 13.

School of Kinesiology, University of British Columbia, Vancouver, British Columbia, Canada.

Background: Exposure to air pollution impairs aspects of pulmonary and autonomic function and causes pulmonary inflammation. However, how exercising in air pollution affects these indices is poorly understood. Therefore, the purpose of this study was to determine the effects of low-intensity and high-intensity cycling with diesel exhaust (DE) exposure on pulmonary function, heart rate variability (HRV), fraction of exhaled nitric oxide (FeNO), norepinephrine and symptoms. Read More

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December 2018

Concurrent Validity of the Bayley-III and the Peabody Developmental Motor Scales-2 at 18 Months.

Phys Occup Ther Pediatr 2018 Dec 12:1-11. Epub 2018 Dec 12.

b British Columbia Children's Hospital Research Institute , Vancouver , BC , Canada.

Aim: To determine concurrent validity between the Bayley Scales of Infant and Toddler Development, 3 edition (Bayley-III) and the Peabody Developmental Motor Scales, 2 edition (PDMS-2).

Methods: Both assessments were administered to 184 preterm children at 18 months corrected age; standard scores for total score, gross motor, and fine motor were calculated for each child. Cross-tabulation and Pearson correlation coefficient (r) determined concurrent validity between the Bayley-III and the PDMS-2 motor domains. Read More

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December 2018

Single Cell Gene Expression to Understand the Dynamic Architecture of the Heart.

Front Cardiovasc Med 2018 21;5:167. Epub 2018 Nov 21.

British Heart Foundation Centre of Research Excellence and British Heart Foundation Centre for Regenerative Medicine, National Heart and Lung Institute, Imperial College London, London, United Kingdom.

The recent development of single cell gene expression technologies, and especially single cell transcriptomics, have revolutionized the way biologists and clinicians investigate organs and organisms, allowing an unprecedented level of resolution to the description of cell demographics in both healthy and diseased states. Single cell transcriptomics provide information on prevalence, heterogeneity, and gene co-expression at the individual cell level. This enables a cell-centric outlook to define intracellular gene regulatory networks and to bridge toward the definition of intercellular pathways otherwise masked in bulk analysis. Read More

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November 2018

Transdifferentiating Astrocytes Into Neurons Using ASCL1 Functionalized With a Novel Intracellular Protein Delivery Technology.

Front Bioeng Biotechnol 2018 21;6:173. Epub 2018 Nov 21.

Division of Medical Sciences, University of Victoria, Victoria, BC, Canada.

Cellular transdifferentiation changes mature cells from one phenotype into another by altering their gene expression patterns. Manipulating expression of transcription factors, proteins that bind to DNA promoter regions, regulates the levels of key developmental genes. Viral delivery of transcription factors can efficiently reprogram somatic cells, but this method possesses undesirable side effects, including mutations leading to oncogenesis. Read More

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November 2018

The Comparative Treatment of Intraventricular Chemotherapy by Ommaya Reservoir vs. Lumbar Puncture in Patients With Leptomeningeal Carcinomatosis.

Front Oncol 2018 20;8:509. Epub 2018 Nov 20.

Emergency Department, National Institute of Neurology and Neurosurgery "Manuel Velasco Suárez" (INNN), Mexico City, Mexico.

Leptomeningeal Carcinomatosis (LCM) represents a state of systemic malignant disease with poor prognosis. The purpose of this study is to compare overall survival (OS) between intraventricular chemotherapy through Ommaya reservoir (OR) and chemotherapy through lumbar puncture (LP) in LCM. Forty adult patients with LCM were included. Read More

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November 2018

A Local Sensitivity Analysis of the Trial of Continuous or Interrupted Chest Compressions during Cardiopulmonary Resuscitation: Is a Local Protocol Change Required?

Cureus 2018 Sep 29;10(9):e3386. Epub 2018 Sep 29.

Emergency Medicine, University of British Columbia, Vancouver, CAN.

Objective The "Trial of Continuous (CCC) or Interrupted Chest Compressions (ICC) during Cardiopulmonary Resuscitation (CPR)" compared two CPR strategies for out-of-hospital cardiac arrest (OHCA). Although results were neutral, there was suggestion of benefit for ICC. However, nearly 50% of study patients had a protocol violation; regional variations may have played a role in protocol adherence and outcomes. Read More

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September 2018

Somatic mutation-associated T follicular helper cell elevation in lung adenocarcinoma.

Oncoimmunology 2018 6;7(12):e1504728. Epub 2018 Sep 6.

British Columbia Cancer Research Centre, Integrative Oncology Department, Vancouver, Canada.

T follicular helper cells (Tfh) play crucial roles in the development of humoral immunity. In the B cell-rich germinal center of lymphoid organs, they select for high-affinity B cells and aid in their maturation. While Tfh have known roles in B cell malignancies and have prognostic value in some epithelial cancers, their role in lung tumour initiation and development is unknown. Read More

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September 2018

Adoptive cell therapy with tumor-infiltrating lymphocytes in patients with metastatic ovarian cancer: a pilot study.

Oncoimmunology 2018 26;7(12):e1502905. Epub 2018 Sep 26.

Center for Cancer Immune Therapy, Department of Hematology, Herlev Hospital, University of Copenhagen, Herlev, Denmark.

:Ovarian cancer (OC) is often diagnosed at an advanced stage with two thirds of patients experiencing recurrent disease with a poor prognosis. Adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TIL) has shown curative potential in malignant melanoma, but has only been investigated scarcely in other cancers. In this pilot study, we tested TIL based ACT in patients with metastatic OC. Read More

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September 2018

"Still learning and evolving in our approaches": patient and stakeholder engagement among Canadian community-based primary health care researchers.

Res Involv Engagem 2018 3;4:47. Epub 2018 Dec 3.

1C.T. Lamont Primary Health Care Research Centre, Bruyère Research Institute, Ottawa, ON Canada.

Plain English Summary: Increasingly, health researchers are conducting their research in partnership with non-researchers such as patients and caregivers, advocacy groups, clinicians, and policymakers. The idea behind this partnership is to make research more relevant and appropriate. However, so far there is not much evidence about how this partnership or engagement actually affects research. Read More

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December 2018

Type B lactic acidosis from fluorouracil in fluorouracil, oxaliplatin and leucovorin treatment for carcinoma of the colon in a hemodialysis patient.

Clin Kidney J 2018 Dec 12;11(6):786-787. Epub 2018 Mar 12.

Department of Medicine, Division of Medical Oncology, BC Cancer Agency, University of British Columbia, Vancouver, BC, Canada.

Type B lactic acidosis complicating malignancies is rare. Increased lactate production from abnormal metabolism of tumor tissue and extensive liver metastases impairing clearance are usual causes. Fluorouracil, commonly used as adjuvant cancer chemotherapy, is not well recognized among drugs that can lead to lactic acidosis. Read More

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December 2018

Simultaneous Assessment of Cardiac Inflammation and Extracellular Matrix Remodeling after Myocardial Infarction.

Circ Cardiovasc Imaging 2018 Nov 15;11(11). Epub 2018 Nov 15.

School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom.

Background: Optimal healing of the myocardium following myocardial infarction (MI) requires a suitable degree of inflammation and its timely resolution, together with a well-orchestrated deposition and degradation of extracellular matrix (ECM) proteins.

Methods And Results: MI and SHAM-operated animals were imaged at 3,7,14 and 21 days with 3T magnetic resonance imaging (MRI) using a F/H surface coil. Mice were injected with F-perfluorocarbon (PFC) nanoparticles to study inflammatory cell recruitment, and with a gadolinium-based elastin-binding contrast agent (Gd-ESMA) to evaluate elastin content. Read More

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November 2018

Quantitative Genetics and Genomics Converge to Accelerate Forest Tree Breeding.

Front Plant Sci 2018 22;9:1693. Epub 2018 Nov 22.

Department of Forest and Conservation Sciences, Faculty of Forestry, University of British Columbia Vancouver, BC, Canada.

Forest tree breeding has been successful at delivering genetically improved material for multiple traits based on recurrent cycles of selection, mating, and testing. However, long breeding cycles, late flowering, variable juvenile-mature correlations, emerging pests and diseases, climate, and market changes, all pose formidable challenges. Genetic dissection approaches such as quantitative trait mapping and association genetics have been fruitless to effectively drive operational marker-assisted selection (MAS) in forest trees, largely because of the complex multifactorial inheritance of most, if not all traits of interest. Read More

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November 2018

In Aptamers They Trust: The Caveats of the SOMAscan Biomarker Discovery Platform from SomaLogic.

Circulation 2018 Nov 26;138(22):2482-2485. Epub 2018 Nov 26.

King's College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences, London, United Kingdom.

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November 2018

Inclusion of mental health in global economic development.

BJPsych Int 2018 Nov;15(4):74-76

Department of Psychiatry, University of British Columbia, Vancouver, Canada.

The APEC Mental Health Roadmap has a vision to strengthen mental health and reduce the economic impact of mental illness in the Asia Pacific. To facilitate its implementation, the APEC Digital Hub will heighten exchange and dissemination of best practices in Asia Pacific mental health partnerships, and increase multi-sectoral recognition to invest in mental health to support economic growth. Read More

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November 2018

Double-Hit Gene Expression Signature Defines a Distinct Subgroup of Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma.

J Clin Oncol 2018 Dec 3:JCO1801583. Epub 2018 Dec 3.

1 British Columbia Cancer Centre for Lymphoid Cancer, Vancouver, British Columbia, Canada.

Purpose: High-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements (HGBL-DH/TH) has a poor outcome after standard chemoimmunotherapy. We sought to understand the biologic underpinnings of HGBL-DH/TH with BCL2 rearrangements (HGBL-DH/TH- BCL2) and diffuse large B-cell lymphoma (DLBCL) morphology through examination of gene expression.

Patients And Methods: We analyzed RNA sequencing data from 157 de novo germinal center B-cell-like (GCB)-DLBCLs, including 25 with HGBL-DH/TH- BCL2, to define a gene expression signature that distinguishes HGBL-DH/TH- BCL2 from other GCB-DLBCLs. Read More

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December 2018

'After-hours' non-elective spine surgery is associated with increased perioperative adverse events in a quaternary center.

Eur Spine J 2018 Dec 6. Epub 2018 Dec 6.

Department of Orthopedic Surgery, Blusson Spinal Cord Centre, University of British Columbia, 6th Floor, 818 West 10th Avenue, Vancouver, BC, V5Z 1M9, Canada.

Purpose: 'After-hours' non-elective spinal surgeries are frequently necessary, and often performed under sub-optimal conditions. This study aimed (1) to compare the characteristics of patients undergoing non-elective spine surgery 'After-hours' as compared to 'In-hours'; and (2) to compare the perioperative adverse events (AEs) between those undergoing non-elective spine surgery 'after-hours' as compared to 'in-hours'.

Methods: In this retrospective study of a prospective non-elective spine surgery cohort performed in a quaternary spine center, surgery was defined as 'in-hours' if performed between 0700 and 1600 h from Monday to Friday or 'after-hours' if more than 50% of the operative time occurred between 1601 and 0659 h, or if performed over the weekend. Read More

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December 2018

Biodistribution, pharmacokinetics, and organ-level dosimetry for Re-AHDD-Lipiodol radioembolization based on quantitative post-treatment SPECT/CT scans.

EJNMMI Phys 2018 Dec 7;5(1):30. Epub 2018 Dec 7.

Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada.

Background: Rhenium-188-labelled-Lipiodol radioembolization is a safe and cost-effective treatment for primary liver cancer. In order to determine correlations between treatment doses and patient response to therapy, accurate patient-specific dosimetry is required. Up to date, the reported dosimetry of Re-Lipiodol has been based on whole-body (WB) planar imaging only, which has limited quantitative accuracy. Read More

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December 2018

A study of tuberculosis in road traffic-killed badgers on the edge of the British bovine TB epidemic area.

Sci Rep 2018 Dec 6;8(1):17206. Epub 2018 Dec 6.

School Veterinary Medicine and Science, University of Nottingham, Nottingham, UK.

The role of badgers in the geographic expansion of the bovine tuberculosis (bTB) epidemic in England is unknown: indeed there have been few published studies of bTB in badgers outside of the Southwest of England where the infection is now endemic in cattle. Cheshire is now on the edge of the expanding area of England in which bTB is considered endemic in cattle. Previous studies, over a decade ago when bovine infection was rare in Cheshire, found no or only few infected badgers in the south eastern area of the county. Read More

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December 2018