16,569 results match your criteria British Journal of Radiology[Journal]


Hemodynamically self-corrected δadc analysis in idiopathic normal pressure hydrocephalus.

Br J Radiol 2019 Feb 13:20180553. Epub 2019 Feb 13.

1 Department of Radiology, Kouseiren Takaoka Hospital , Takaoka, Toyama , Japan.

Objective:: To clarify the cause of higher water fluctuation of the brain in idiopathic normal pressure hydrocephalus (iNPH), we assessed change in hemodynamic-independent apparent diffusion coefficient during the cardiac cycle (ΔADC) in iNPH.

Methods:: Electrocardiographically synchronized single-shot diffusion echo-planer (b = 0, 500, and 1000  s/mm ) was performed in healthy volunteers, atrophic ventricular dilation group, and iNPH group, respectively. The ΔADC (b = 0  and 1000  s/mm ) and maximum ADC (b = 0  and 500  s/mm ) in the cardiac cycles were measured at the frontal white matter in the brain. Read More

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February 2019

Quantitative diagnosis of osteoporosis using lumbar spine signal intensity in magnetic resonance imaging.

Br J Radiol 2019 Feb 13:20180774. Epub 2019 Feb 13.

1 Department of Radiology, Isfahan University of Medical Sciences , Isfahan , Iran.

Objective:: Osteoporosis is the most common metabolic bone disease that is not recognized in many elderly people. To determine the cause of low back pain, lumbosacral MRI is done for a large population who may not have gone under dual energy X-ray absorptiometry (DXA). The aim of this study was to predict bone density using lumbar spine signals in lumbosacral MRI in high risk patients for osteoporosis including post-menopausal females and calculate a threshold for a new quantitative MRI-based score to be used in estimation of lumbar spine bone mass density. Read More

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February 2019
1 Read

Internet-based measurement of visual assessment skill of trainee radiologists: developing a sensitive tool.

Br J Radiol 2019 Feb 7:20180958. Epub 2019 Feb 7.

5 Department of Radiology, Sheffield Children's NHS Foundation Trust , Sheffield , United Kingdom.

Objective:: Expert radiologists exhibit high levels of visual diagnostic accuracy from review of radiological images, doing so after accumulating years of training and experience. To train new radiologists, learning interventions must focus on the development of these skills. By developing a web-based measure of image assessment, a key part of visual diagnosis, we aimed to capture differences in the performance of expert, trainee and non-radiologists. Read More

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http://dx.doi.org/10.1259/bjr.20180958DOI Listing
February 2019
1 Read
1.533 Impact Factor

Does the clinical information play a role in the magnetic resonance diagnostic confidence analysis of ovarian and deep endometriosis?

Br J Radiol 2019 Feb 7:20180548. Epub 2019 Feb 7.

2 Department of Gynecology, Azienda Ospedaliero Universitaria (A.O.U.) , Cagliari , Italy.

Objective:: Some recent studies have explored how the experience in the observers change their performance in the endometriosis detection using MRI but the effects of the clinical information remains uncertain. The purpose of this study was to assess the effect of the clinical information in the diagnostic confidence in the MRI diagnosis of endometriosis.

Methods And Materials:: Institutional Review Board was obtained. Read More

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February 2019
1 Read

Dose painting by dynamic irradiation delivery on an image-guided small animal radiotherapy platform.

Br J Radiol 2019 Feb 12:20180744. Epub 2019 Feb 12.

1 Department of Radiation Oncology, (MAASTRO), GROW - School for Oncology and Developmental Biology, Maastricht University Medical Center , Maastricht , The Netherlands.

Objective:: Using synchronized three-dimensional stage translation and multiangle radiation delivery to improve conformality and homogeneity of radiation delivery to complexly shaped target volumes for precision preclinical radiotherapy.

Methods:: A CT image of a mouse was used to design irradiation plans to target the spinal cord and an orthotopic lung tumour. A dose painting method is proposed that combines heterogeneous two-dimensional area irradiations from multiple beam directions. Read More

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February 2019

Added value of diffusion-weighted imaging for evaluation of extramural venous invasion in patients with primary rectal cancer.

Br J Radiol 2019 Jan 30:20180821. Epub 2019 Jan 30.

1 Department of Radiology, Inje University College of Medicine, Haeundae Paik Hospital , Busan , Korea.

Objective:: To evaluate the added value of diffusion-weighted imaging (DWI) to T weighted imaging (T WI) for detection of extramural venous invasion (EMVI) in patients with primary rectal cancer.

Methods:: 79 patients (50 men, 29 females, mean age 67.4 years, range 37-87 years) who had undergone rectal MRI and subsequently received surgical resection were included. Read More

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http://dx.doi.org/10.1259/bjr.20180821DOI Listing
January 2019

Recent developments in non-coplanar radiotherapy.

Br J Radiol 2019 Feb 1:20180908. Epub 2019 Feb 1.

1 Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust , London , UK.

This paper gives an overview of recent developments in non-coplanar intensity modulated radiotherapy (IMRT) and volumetric modulated arc therapy (VMAT). Modern linear accelerators are capable of automating motion around multiple axes, allowing efficient delivery of highly non-coplanar radiotherapy techniques. Novel techniques developed for C-arm and non-standard linac geometries, methods of optimization, and clinical applications are reviewed. Read More

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February 2019

The value of sonoelastography in the diagnosis of supraspinatus tendinopathy-a comparison study.

Br J Radiol 2019 Jan 28:20180951. Epub 2019 Jan 28.

1 Department of Radiodiagnosis and Imaging, Bharati Hospital and Research Center, Dhankawadi , Pune , India.

Objective:: This study assessed the association between tendon stiffness on sonoelastography and grades of tendinopathy on MRI in patients with supraspinatus tendinopathy.

Methods:: 25 consecutive adult patients with clinically suspected supraspinatus tendinopathy and no prior history of trauma referred for MRI of the shoulder were selected for this study. The supraspinatus tendinopathy was graded in consonance with MRI findings (Grade I, normal; Grade II, mild tendinopathy; Grade III, moderate tendinopathy; and Grade IV, marked tendinopathy). Read More

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January 2019
1 Read

Detection of avascular necrosis on routine diffusion-weighted whole body MRI in patients with multiple myeloma.

Br J Radiol 2019 Feb 12:20180822. Epub 2019 Feb 12.

4 Department of Radiology, The Royal Marsden Hospital and Faculty of Radiotherapy and Imaging Institute of Cancer Research , London , UK.

Objective:: Current therapies for multiple myeloma, which include corticosteroids, increase risk of avascular necrosis. The aim of this study was to assess incidental detection of femoral head avascular necrosis on routine whole body MRI including diffusion weighted MRI.

Methods:: All whole body MRI studies, performed on patients with known multiple myeloma between 1 January 2010 to 1 May 2017 were assessed for features of avascular necrosis. Read More

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February 2019
1 Read
1.533 Impact Factor

Comparison of prostate delineation on multimodality imaging for MR-guided radiotherapy.

Br J Radiol 2019 Jan 24:20180948. Epub 2019 Jan 24.

1 The Royal Marsden Hospital NHS Foundation Trust, Downs Road , Sutton , United Kingdom.

Objective:: With increasing incorporation of MRI in radiotherapy, we investigate two MRI sequences for prostate delineation in radiographer-led image guidance.

Methods:: Five therapeutic radiographers contoured the prostate individually on CT, T weighted (T W) and T * weighted (T *W) imaging for 10 patients. Contours were analysed with Monaco ADMIRE (research v. Read More

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January 2019

Quantitative analysis of image metrics for reduced and standard dose pediatric F-FDG PET/MRI examinations.

Br J Radiol 2019 Jan 23:20180438. Epub 2019 Jan 23.

1 Nuclear Medicine Unit, Department of Medicine DIMED, University-Hospital of Padova , Padova , Italy.

Objective:: The study performs a comprehensive analysis of image metrics to objectively support the reduction of injected activity in pediatric oncology F-FDG PET/MR (F-fludeoxyglucose PET/MR) examinations. Contrast-to-Noise Ratio (CNR), Normalized Noise (NN), tumor burden, and standardized uptake value (SUV) parameters stability were investigated to robustly define the acceptable reduced activity level that preserves the clinical utility of images, considering different PET applications.

Methods:: 21 PET/MRI examinations performed on a 3-Tesla Biograph mMR scanner were analyzed. Read More

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January 2019

Mild hyperthermia as a localized radiosensitizer for deep-seated tumors: investigation in an orthotopic prostate cancer model in mice.

Br J Radiol 2019 Feb 12:20180759. Epub 2019 Feb 12.

Department of Radiation Oncology, University of Maryland School of Medicine , Baltimore, MD , USA.

Objective:: Non-ablative or mild hyperthermia (HT) has been shown in preclinical (and clinical) studies as a localized radiosensitizer that enhances the tumoricidal effects of radiation. Most preclinical in vivo HT studies use subcutaneous tumor models which do not adequately represent clinical conditions (e.g. Read More

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February 2019

Impact of different image reconstructions on PET quantification in non-small cell lung cancer: a comparison of adenocarcinoma and squamous cell carcinoma.

Br J Radiol 2019 Jan 23:20180792. Epub 2019 Jan 23.

1 Department of Nuclear Medicine, University Hospital Zurich , Zurich , Switzerland.

Objective:: Positron emission tomography (PET) using 18F-fluordeoxyglucose (F-FDG) is an established imaging modality for tumor staging in patients with non-small cell lung cancer (NSCLC). There is a growing interest in using F-FDG PET for therapy response assessment in NSCLC which relies on quantitative PET parameters such as standardized uptake values (SUV). Different reconstruction algorithms in PET may affect SUV. Read More

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http://dx.doi.org/10.1259/bjr.20180792DOI Listing
January 2019
1 Read

The MRI characteristics of non-mass enhancement lesions of the breast: associations with malignancy.

Authors:
Hale Aydin

Br J Radiol 2019 Jan 29:20180464. Epub 2019 Jan 29.

1 Department of Radiology, Dr AY Ankara Oncology Research and Training Hospital , Ankara , Turkey.

Objective:: The American College of Radiology updated the terms used for expressing the imaging characteristics of non-mass enhancement (NME) lesions in the fifth edition of the breast imaging-reporting data system (BI-RADS) lexicon. Both the distribution and internal enhancement descriptors were revised for NME lesions. Our aim was to determine the MRI characteristics of NME lesions and to investigate their association with malignancy. Read More

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January 2019
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Stereotactic body radiation therapy in cholangiocarcinoma: a systematic review.

Br J Radiol 2019 Feb 7:20180688. Epub 2019 Feb 7.

1 Department of Experimental, Diagnostic and Specialty Medicine - DIMES, University of Bologna, S. Orsola-Malpighi Hospital , Bologna , Italy.

Objective: Stereotactic body radiation therapy (SBRT) has been used in the treatment of cholangiocarcinoma (CC) but toxicity and clinical results of SBRT in CC are still limited and sparse. Therefore, the aim of this systematic review was to analyze the results of SBRT in the setting of advanced CC.

Methods: A systematic literature search was conducted on PubMed, Scopus, and Cochrane library using the PRISMA methodology. Read More

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February 2019

Disc and nerve root findings on lumbar MRI with straightened v s flexed hips and knees-pilot study.

Br J Radiol 2019 Jan 17:20180851. Epub 2019 Jan 17.

3 Western Norway University of Applied Sciences , Bergen , Norway.

Objective:: To compare disc and nerve root findings, image quality, and pain between supine lumbar MRI positions with straightened v s flexed hips and knees.

Methods:: In this prospective pilot study, 14 adults with sciatica or suspected lumbar radiculopathy underwent MRI supine with their hips and knees flexed and then straightened. For each position, two experienced radiologists assessed disc contour, location/size of disc herniation, nerve root affection, image quality, image evaluation difficulty, and sagittal angles between the vertebral bodies at each disc level L3-S1. Read More

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http://dx.doi.org/10.1259/bjr.20180851DOI Listing
January 2019
2 Reads

Intracranial aneurysms at higher clinical risk for rupture demonstrate increased wall enhancement and thinning on multicontrast 3D vessel wall MRI.

Br J Radiol 2019 Jan 30:20180950. Epub 2019 Jan 30.

1 Department of Radiology, University of Washington , Seattle, WA , USA.

Objective:: Identification of aneurysms at risk for rupture is important and challenging. We sought to evaluate if intracranial vessel wall (IVW) imaging characteristics of unruptured aneurysms correlate with clinical risk factors for rupture.

Methods:: Patients with unruptured intracranial aneurysms were prospectively recruited and underwent a multi contrast 3D IVW protocol between April 6, 2016 and August 29, 2017. Read More

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January 2019
4 Reads

An Australian local diagnostic reference level for paediatric whole-body F-FDG PET/CT.

Br J Radiol 2019 Jan 17:20180879. Epub 2019 Jan 17.

6 The Discipline of Medical Radiation Sciences, Faculty of Health Sciences, The University of Sydney , Sydney, NSW , Australia.

Objective:: The aim of this study is to report a local Diagnostic Reference Level (DRL) for paediatric whole-body (WB) fluorodeoxyglucose (F-FDG) positron emission tomography (PET) computed tomography (CT) examinations.

Method:: The Australian Radiation Protection and Nuclear Safety Agency (ARPANSA) national DRL (NDRL) age category (0-4 years and 5-14 years), the International Commission of Radiological Protection age category (ICRP age) (< 1,> 1-5, > 5-10, and > 10-15 years), and European guideline weight category (e.g. Read More

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January 2019
1 Read

Preclinical models of radiation-induced lung damage: challenges and opportunities for small animal radiotherapy.

Br J Radiol 2019 Feb 13:20180473. Epub 2019 Feb 13.

1 Centre for Cancer Research and Cell Biology, Queen's University Belfast , Belfast , Northern Ireland, UK.

Despite a major paradigm shift in radiotherapy planning and delivery over the past three decades with continuing refinements, radiation-induced lung damage (RILD) remains a major dose limiting toxicity in patients receiving thoracic irradiations. Our current understanding of the biological processes involved in RILD which includes DNA damage, inflammation, senescence and fibrosis, is based on clinical observations and experimental studies in mouse models using conventional radiation exposures. Whilst these studies have provided vital information on the pulmonary radiation response, the current implementation of small animal irradiators is enabling refinements in the precision and accuracy of dose delivery to mice which can be applied to studies of RILD. Read More

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February 2019
9 Reads

The associated factors for radiation dose variation in cardiac CT angiography.

Br J Radiol 2019 Jan 31:20180793. Epub 2019 Jan 31.

1 The University of Sydney, Faculty of Health Sciences, Discipline of Medical Radiation Science , Sydney, NSW , Australia.

Methods:: A questionnaire was distributed to CT centres across Australia and Saudi Arabia. All participating centres collected data for adults who underwent a CCTA procedure. The questionnaire gathered information about the examination protocol, scanning parameters, patient parameters, and volume CT dose index (CTDI vol) and dose-length product (DLP). Read More

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January 2019
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MRI-based assessment and characterization of epicardial and paracardial fat depots in the context of impaired glucose metabolism and subclinical left-ventricular alterations.

Br J Radiol 2019 Jan 28:20180562. Epub 2019 Jan 28.

11 Department of Radiology, University Hospital Freiburg , Freiburg , Germany.

Objective:: To analyze the associations between epicardial and paracardial fat and impaired glucose tolerance as well as left ventricular (LV) alterations.

Methods:: 400 subjects underwent 3 T MRI and fat depots were delineated in the four chamber-view of the steady-state free precession cine sequence (repetition time: 29.97 ms; echo time 1. Read More

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January 2019
4 Reads

Should we be moving to a national standardized non-gadolinium MR imaging protocol for the surveillance of vestibular schwannomas?

Br J Radiol 2019 Jan 23:20180833. Epub 2019 Jan 23.

1 Department of Neuroradiology, Leeds Teaching Hospitals NHS Trust , Leeds , UK.

Objectives:: To examine whether the model of Getting It Right First Time (GIRFT) could be relevant to the surveillance of non-operated vestibular schwannomas (vs) by testing the following hypotheses: (1) in the UK there is a great variation in the imaging protocol for the follow-up of vs; (2) high-resolution, T weighted MRI (HRT W-MRI) has an equivalent accuracy to gadolinium-enhanced T weighted MRI (Gd-MRI) in the assessment of vs size and; (3) imaging with HRT W-MRI rather than Gd-MRI could offer financial savings.

Methods:: Two neuroradiologists independently performed measurements of 50 vs imaged with HRT W-MRI and Gd-MRI. Differences in mean tumour measurements between HRT W-MRI and Gd-MRI were determined, as were intra- and interobserver concordance. Read More

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http://dx.doi.org/10.1259/bjr.20180833DOI Listing
January 2019
1 Read

Imaging features of pure and mixed forms of mucinous breast carcinoma with histopathological correlation.

Br J Radiol 2019 Jan 11:20180810. Epub 2019 Jan 11.

5 Cedars Breast Clinic, McGill University Health Centre, Royal Victoria Hospital , Montreal, QC , Canada.

Methods:: A cross-sectional study identified cases of mucinous breast carcinoma from pathology records (2004-2012). Two radiologists classified imaging features by consensus and two pathologists classified cases into pure or mixed subtypes. Bi-variable analyses were performed using relevant statistical tests. Read More

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January 2019
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Diagnostic performance of contrast-enhanced and unenhanced combined pulmonary artery MRI and magnetic resonance venography techniques in the diagnosis of venous thromboembolism.

Br J Radiol 2019 Jan 10:20180695. Epub 2019 Jan 10.

3 Department of Radiology, Tekden Hospital , Denizli , Turkey.

Objective:: We aimed to determine the diagnostic performance of the contrast-enhanced and unenhanced combined pulmonary arterial MRI and magnetic resonance venography techniques in the diagnosis of venous thromboembolism (VTE).

Methods:: 44 patients who underwent CT pulmonary angiography (CTPA) for suspected PE constituted the study population. Patients underwent combined pulmonary and lower extremity MRI, and Doppler ultrasonography within 72 h after CTPA. Read More

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January 2019
3 Reads

Value of CT iterative metal artifact reduction in PET/CT-clinical evaluation in 100 patients.

Br J Radiol 2019 Jan 14:20180756. Epub 2019 Jan 14.

1 Department of Diagnostic and Interventional Radiology, University Hospital Tuebingen , Tuebingen , Germany.

Objective:: To assess the technical feasibility and diagnostic benefit of CT iterative metal artifact reduction (iMAR) in patients with metal implants undergoing positron emission tomography (PET/CT.

Methods:: PET/CTs of 100 patients with metal implants in different anatomical localization were retrospectively analyzed. CT data were reconstructed with iMAR and without iMAR (noMAR) and used in comparison for PET attenuation correction, generating iMAR-corrected and noMAR PET data. Read More

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January 2019
2 Reads

The clinical value of imaging in primary cutaneous lymphomas: Role of high resolution ultrasound and PET-CT.

Br J Radiol 2019 Jan 4:20180904. Epub 2019 Jan 4.

4 Dermatology Service, Hospital Universitario, Puerta de Hierro, Majadahonda , Madrid , Spain.

Background:: Primary cutaneous lymphoma is a rare extranodal non-Hodgkin's lymphoma confined to the skin. The data on the imaging findings of primary cutaneous lymphomas are largely lacking and the current diagnosis is based on clinical and histopathological examination. With the advances in dermatological ultrasound and molecular imaging, newer perspectives in the evaluation of cutaneous lymphomas are available. Read More

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http://dx.doi.org/10.1259/bjr.20180904DOI Listing
January 2019
10 Reads

Acute Q fever pneumonia: high-resolution computed tomographic findings in six patients.

Br J Radiol 2019 Jan 4:20180292. Epub 2019 Jan 4.

2 Department of Radiology, Federal University of Rio de Janeiro , Rio de Janeiro , Brazil.

Methods:: We analyzed high-resolution CT (HRCT) findings from six male patients (mean age, 22.6 years) with confirmed diagnoses of acute Q fever. Two chest radiologists analyzed the images and reached decisions by consensus. Read More

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http://dx.doi.org/10.1259/bjr.20180292DOI Listing
January 2019
2 Reads

Lessons learnt from pathologic imaging correlation in the liver: an historical perspective.

Br J Radiol 2019 Jan 10:20180701. Epub 2019 Jan 10.

1 Department of Radiology, Hôpitaux Universitaires Paris Nord Val de Seine , Clichy , France.

Imaging and pathology can be considered as two sides of the same diagnostic coin. Yet, pathology remains the gold-standard technique for the diagnosis of most diseases. Nevertheless, significant and constant progress in imaging has been made thanks to fruitful rad-path correlations. Read More

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January 2019
1 Read

MR imaging findings differentiating uterine submucosal polypoid adenomyomas from endometrial polyps.

Br J Radiol 2019 Jan 10:20180430. Epub 2019 Jan 10.

1 Department of Radiology, Gifu University School of Medicine , Gifu , Japan.

Objective:: This study aimed to assess the efficacy of MRI for differentiating between uterine submucosal polypoid adenomyomas (PAs) and endometrial polyps (EPs).

Methods:: MRI was used to examine 40 histopathologically confirmed benign polypoid endometrial tumors (8submucosal PAs and 32 EPs). Atypical PAs were excluded from this study. Read More

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January 2019
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Low-grade epithelial ovarian cancer: what a radiologist should know.

Br J Radiol 2019 Jan 31:20180571. Epub 2019 Jan 31.

1 Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center , Houston, TX , USA.

Ovarian cancer accounts for the death of over 100,000 females every year and is the most lethal gynecological malignancy. Low-grade serous ovarian carcinoma (LGSOC) and high-grade serous ovarian carcinoma (HGSOC) have been found to represent two distinct entities based on their molecular differences, clinical course, and response to chemotherapy. Currently, all ovarian cancers are staged according to the revised staging system of the International Federation of Gynecology and Obstetrics (FIGO). Read More

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January 2019
7 Reads

Imaging in myeloma with focus on advanced imaging techniques.

Br J Radiol 2019 Jan 3:20180768. Epub 2019 Jan 3.

3 The Royal Marsden Hospital NHS Foundation Trust , London , UK.

In recent years, there have been major advances in the imaging of myeloma with whole body MRI incorporating diffusion-weighted imaging, emerging as the most sensitive modality. Imaging is now a key component in the work-up of patients with a suspected diagnosis of myeloma. The International Myeloma Working Group now specifies that more than one focal lesion on MRI or lytic lesion on whole body low-dose CT or fludeoxyglucose (FDG) PET/CT fulfil the criteria for bone damage requiring therapy. Read More

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January 2019
7 Reads

The split sign: The MRI equivalent of the bell clapper deformity.

Br J Radiol 2019 Jan 23:20180312. Epub 2019 Jan 23.

1 Department of Radiology, Kyoto Prefectural University of Medicine , Kyoto , Japan.

Methods:: The cases of eight patients who underwent MRI and surgery for acute scrotum between January 2010 and January 2017 were evaluated. We recorded whether hyperintense fluid on T weighted images existed between the posterior aspect of the epididymis and the scrotal wall ("split sign") and investigated if it correlated with BCD in surgical findings.

Results:: In one patient without hydrocele, readers were unable to evaluate the anatomy of the tunica vaginalis. Read More

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January 2019
7 Reads

A post-processing method based on interphase motion correction and averaging to improve image quality of 4D magnetic resonance imaging: a clinical feasibility study.

Br J Radiol 2019 Jan 3:20180424. Epub 2019 Jan 3.

1 Department of Biomedical Sciences, Biomedical Imaging Research Institute, Cedars Sinai Medical Center , Los Angeles, CA , USA.

Methods:: Nine patients (seven pancreas, one liver, and one lung) were recruited. 4D-MRI was performed using two prototype k-space sorted techniques, stack-of-stars (SOS) and koosh-ball (KB) acquisitions. Post-processing using MoCoAve was implemented for both methods. Read More

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January 2019
1 Read
1.533 Impact Factor

Magnetic resonance imaging-guided radiation therapy using animal models of glioblastoma.

Br J Radiol 2019 Jan 17:20180713. Epub 2019 Jan 17.

2 Department of Nuclear Medicine, Ghent University Hospital , Ghent , Belgium.

Glioblastoma is the most aggressive and most common malignant primary brain tumour in adults and has a high mortality and morbidity. Because local tumour control in glioblastoma patients is still elusive in the majority of patients, there is an urgent need for alternative treatment strategies. However, to implement changes to the existing clinical standard of care, research must be conducted to develop alternative treatment strategies. Read More

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January 2019
8 Reads

Ga-HBEDD PSMA-11 PET/CT staging prior to radical prostatectomy in prostate cancer patients: Diagnostic and predictive value for the biochemical response to surgery.

Br J Radiol 2019 Jan 23:20180667. Epub 2019 Jan 23.

2 Clinical Prostate Cancer Research, The Garvan Institute of Medical Research , Sydney, NSW , Australia.

Methods:: We analysed results of 142 males with staging PSMA prior to radical prostatectomy (RP). Data collected included PSMA PET/CT, bone scan (30/142), mpMRI (112/142), and pathological T stage (pT) stage, Gleason score, surgical margins and lymph node status at RP. Prostate-specific antigen (PSA) was documented at staging scan, and following surgery (median 45 days (interquartile range 38-59). Read More

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January 2019
5 Reads

Value of CT spectral imaging in the differential diagnosis of thymoma and mediastinal lymphoma.

Br J Radiol 2018 Dec 3:20180598. Epub 2018 Dec 3.

1 Department of Radiology, Lanzhou University Second Hospital , Lanzhou , PR China.

Objective:: To investigate the imaging characteristics of thymoma and mediastinal lymphoma using spectral CT and evaluate whether the quantitative information can improve the differential diagnosis of these diseases.

Methods:: This retrospective study was approved by the institutional review board, and written informed consent was obtained from all patients. Overall, 39 patients with mediastinal tumors (24 thymomas and 15 mediastinal lymphomas) were examined with CT spectral imaging during the arterial phase (AP) and venous phase (VP). Read More

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December 2018
3 Reads

Advances in acoustic monitoring and control of focused ultrasound-mediated increases in blood-brain barrier permeability.

Br J Radiol 2018 Dec 3:20180601. Epub 2018 Dec 3.

1 Physical Sciences Platform, Sunnybrook Research Institute , Toronto, ON , Canada.

Transcranial focused ultrasound (FUS) combined with intravenously circulating microbubbles can transiently and selectively increase blood-brain barrier permeability to enable targeted drug delivery to the central nervous system, and is a technique that has the potential to revolutionize the way neurological diseases are managed in medical practice. Clinical testing of this approach is currently underway in patients with brain tumors, early Alzheimer's disease, and amyotrophic lateral sclerosis. A major challenge that needs to be addressed in order for widespread clinical adoption of FUS-mediated blood-brain barrier permeabilization to occur is the development of systems and methods for real-time treatment monitoring and control, to ensure that safe and effective acoustic exposure levels are maintained throughout the procedures. Read More

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December 2018
11 Reads

Murine vs human tissue compositions: implications of using human tissue compositions for photon energy absorption in mice.

Br J Radiol 2018 Nov 30:20180454. Epub 2018 Nov 30.

1 Department of Radiation Oncology (MAASTRO), GROW-School for Oncology and Developmental Biology, Maastricht University Medical Centre , Maastricht , The Netherlands.

Methods:: Dual energy CT (DECT) images of 9 female mice were used to extract the effective atomic number Z and the relative electron density ρ for each voxel in the images. To investigate the influence of the tissue compositions on the absorbed radiation dose for a typical kilovoltage photon beam, mass energy-absorption coefficients μ/ρ were calculated for 10 different tissues in each mouse.

Results: Differences between human and murine tissue compositions can lead to errors around 7. Read More

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https://www.birpublications.org/doi/10.1259/bjr.20180454
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http://dx.doi.org/10.1259/bjr.20180454DOI Listing
November 2018
2 Reads

UK national audit of safety checks for radiology interventions.

Br J Radiol 2019 Feb 30;92(1094):20180637. Epub 2018 Nov 30.

1 Department of Radiology, Norfolk and Norwich University Hospitals NHS Foundation Trust , Norfolk , UK.

Objective:: To reaudit the use of safety checklists in radiology departments in NHS departments throughout the UK.

Methods:: This audit was performed on behalf of The Royal College of Radiologists Audit Committee in 2016 and was sent to radiology audit leads at every NHS department in the UK to determine the use of safety checks in various modalities and subspecialties. Free-form text boxes gathered data on problems with checklist implementation. Read More

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https://www.birpublications.org/doi/10.1259/bjr.20180637
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http://dx.doi.org/10.1259/bjr.20180637DOI Listing
February 2019
1 Read

Masses in the Era of screening tomosynthesis: Is diagnostic ultrasound sufficient?

Br J Radiol 2018 Nov 29:20180801. Epub 2018 Nov 29.

1 Department of Radiology, Mayo Clinic , Rochester MN , US.

Objectives:: The purpose of this study is to compare diagnostic outcomes of digital breast tomosynthesis screen-detected masses worked up with mammography first with those evaluated with diagnostic ultrasound initially.

Methods:: All masses recalled from screening digital breast tomosynthesis between 7/1/17 and 12/31/17 that were sent either to diagnostic mammography or ultrasound were compared. Size, shape, margins, visibility on ultrasound, diagnostic assessment and pathology of all masses along with breast density were evaluated. Read More

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November 2018
1 Read

The many faces of mathematical modelling in oncology.

Br J Radiol 2019 Jan 28;92(1093):20180856. Epub 2018 Nov 28.

CRUK/MRC Oxford Institute, Department of Oncology, Medical Science Division, University of Oxford , Oxford , United Kingdom.

The application of modelling to solve problems in biology and medicine, and specifically in oncology and radiation therapy, is increasingly established and holds big promise. We provide an overview of the basic concepts of the field and its current state, along with new tools available and future directions for research. We will outline radiobiology models, examples of other anticancer therapy models, multiscale modelling, and we will discuss mechanistic and phenomenological approaches to modelling. Read More

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January 2019
1 Read

An orthotopic non-small cell lung cancer model for image-guided small animal radiotherapy platforms.

Br J Radiol 2018 Nov 30:20180476. Epub 2018 Nov 30.

1 Department of Radiotherapy, GROW-School for Oncology & Developmental Biology, Maastricht University Medical Centre , Maastricht , The Netherlands.

Methods:: An orthotopic non-small cell lung cancer model in NMRI-nude mice was established to investigate the complementary information acquired from 80 kVp microcone-beam CT (micro-CBCT) and bioluminescence imaging (BLI) using different angles and filter settings. Different micro-CBCT-based radiation-delivery plans were evaluated based on their dose-volume histogram metrics of tumor and organs at risk to select the optimal treatment plan.

Results:: H1299 cell suspensions injected directly into the lung render exponentially growing single tumor nodules whose CBCT-based volume quantification strongly correlated with BLI-integrated intensity. Read More

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November 2018
10 Reads

The use of texture-based radiomics CT analysis to predict outcomes in early-stage non-small cell lung cancer treated with stereotactic ablative radiotherapy.

Br J Radiol 2019 Feb 20;92(1094):20180228. Epub 2018 Nov 20.

3 Department of Biomedical Data Science, Radiology, and Medicine (Biomedical Informatics Research), Stanford University School of Medicine , Stanford, CA , USA.

Objective:: Stereotactic ablative radiotherapy (SABR) is being increasingly used as a non-invasive treatment for early-stage non-small cell lung cancer (NSCLC). A non-invasive method to estimate treatment outcomes in these patients would be valuable, especially since access to tissue specimens is often difficult in these cases.

Methods:: We developed a method to predict survival following SABR in NSCLC patients using analysis of quantitative image features on pre-treatment CT images. Read More

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February 2019
9 Reads

Impact of modern radiotherapy techniques on survival outcomes for unselected patients with large volume non-small cell lung cancer.

Br J Radiol 2018 Nov 29:20180928. Epub 2018 Nov 29.

1 Department of Radiation Oncology, Tata Medical Center, Kolkata , India.

Objective:: Intensity modulated radiotherapy (IMRT) is used, where necessary, for bulky or complex-shaped, locally advanced, non-small cell lung cancer (NSCLC). We evaluate our real-world experience with radical radiotherapy including concurrent chemoradiation (CCRT), and analyse the impact of IMRT on survival outcomes in patients with larger volume disease.

Methods:: All patients treated between May 2011 and December 2017 were included. Read More

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November 2018
12 Reads

Volumetric analysis at abdominal CT: oncologic and non-oncologic applications.

Br J Radiol 2018 Nov 30:20180631. Epub 2018 Nov 30.

1 Department of Radiology, The University of Wisconsin School of Medicine & Public Health , Madison, WI , USA.

Volumetric analysis is an objective three-dimensional assessment of a lesion or organ that may more accurately depict the burden of complex objects compared to traditional linear size measurement. Small changes in linear size are amplified by corresponding changes in volume, which could have significant clinical implications. Though early methods of calculating volumes were time-consuming and laborious, multiple software platforms are now available with varying degrees of user-software interaction ranging from manual to fully automated. Read More

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https://www.birpublications.org/doi/10.1259/bjr.20180631
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November 2018
16 Reads

Error in radiology-where are we now?

Authors:
Giles Maskell

Br J Radiol 2018 Nov 28:20180845. Epub 2018 Nov 28.

1 Royal Cornwall Hospital , Truro , UK.

Error is inherent in radiological practice. Our awareness of the extent of this and the reasons behind it has increased in recent times. Our next step must be the development of a shared understanding with our patients of the limitations as well as the huge benefits of medical imaging. Read More

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November 2018
1 Read

Distinguishing adrenal adenomas from non-adenomas with multidetector CT: evaluation of percentage washout values at a short time delay triphasic enhanced CT.

Br J Radiol 2019 Feb 28;92(1094):20180429. Epub 2018 Nov 28.

1 Department of Radiology, China-Japan Friendship Hospital , Beijing , China.

Objective:: To retrospectively evaluate the diagnostic values of absolute percentage washout ratio (APW) and relative percentage washout ratio (RPW) obtained from a short time delay triphasic enhanced CT in distinguishing adenomas from non-adenomas.

Methods:: The study population consisted of 116 patients (58 males and 58 females; mean age, 52 years; age range, 23-89 years) with 116 adrenal masses from 2010 to 2016. Absolute attenuation values in each phase of CT were measured, and then the APW and RPW were calculated. Read More

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February 2019
2 Reads

Hypofractionated radiotherapy with concomitant boost for breast cancer: a dose escalation study.

Br J Radiol 2018 Nov 28:20180169. Epub 2018 Nov 28.

1 Radiotherapy Unit, Campus Bio-Medico University , Rome , Italy.

Methods:: Patients with breast cancer with pathological stage pT and at least one risk factor for local recurrence such as N1 disease, lymphovascular invasion, extensive intraductal component, close margins, non-hormone sensitive disease, grading G3 were enrolled. Patients were treated with hypofractionated RT to whole breast with a dose of 40.05 Gy in 15 fractions. Read More

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http://dx.doi.org/10.1259/bjr.20180169DOI Listing
November 2018
3 Reads

An Evaluation of Techniques for Dose Calculation on Cone Beam Computed Tomography.

Br J Radiol 2018 Nov 15:20180383. Epub 2018 Nov 15.

1 Centre for Cancer Research and Cell Biology, Queen's University Belfast , Belfast, NN , UK.

Objective:: To assess the accuracy and efficiency of four different techniques, thus determining the optimum method for recalculating dose on cone beam CT (CBCT) images acquired during radiotherapy treatments.

Methods:: Four established techniques were investigated and their accuracy assessed via dose calculations: (1) applying a standard planning CT (pCT) calibration curve, (2) applying a CBCT site specific calibration curve, (3) performing a density override and (4) using deformable registration. Each technique was applied to 15 patients receiving volumetric modulated arc therapy to one of three treatment sites, head and neck, lung and prostate. Read More

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https://www.birpublications.org/doi/10.1259/bjr.20180383
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November 2018
13 Reads

Population-based opportunistic osteoporosis screening: Validation of a fully automated CT tool for assessing longitudinal BMD changes.

Br J Radiol 2019 Feb 28;92(1094):20180726. Epub 2018 Nov 28.

2 Department of Radiology and Imaging Sciences, National Institutes of Health Clinical Center , Bethesda, MD , USA.

Methods:: The automated BMD tool was retrospectively applied to non-contrast abdominal CT scans in 1603 consecutive asymptomatic adults (mean age, 55.9 years; 770 M/833 F) undergoing longitudinal screening (mean interval, 5.7 years; range, 1. Read More

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February 2019
10 Reads