20,279 results match your criteria British Journal of Ophthalmology[Journal]


Dynamic assessment of the tear film muco-aqueous and lipid layers using a novel tear film imager (TFI).

Br J Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Department of Ophthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Purpose: The objective of the study was to assess a new technology, the tear film imager (TFI), which can dynamically image the muco-aqueous and lipid layers.

Methods: Prospective pilot case series of individuals with and without dry eye (DE). Two sequential images were obtained with the TFI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313379DOI Listing

Decreased epithelial to corneal thickness ratio in healthy fellow eyes of patients with unilateral bullous keratopathy.

Br J Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Ophthalmology, Military Maedical Academy, Saint Petersburg, Russian Federation.

Purpose: To study the relationship between epithelial thickness (ET) and corneal thickness (CT) in healthy fellow eyes of patients with unilateral bullous keratopathy (BKP) and healthy subjects.

Methods: Seventeen BKP patients (nine males, eight females, 73.2±10. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313648DOI Listing

Comorbidity of dementia and age-related macular degeneration calls for clinical awareness: a meta-analysis.

Br J Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China

Aim: To determine the association between dementia and age-related macular degeneration (AMD) using meta-analysis.

Methods: We searched in the MEDLINE, EMBASE, Web of Knowledge, PsycInfo and Cochrane database of systematic reviews for studies published from March 1959 to March 2018. We included cross-sectional, case-control and cohort studies that evaluated the association of dementia/Alzheimer's disease (AD) with AMD (as outcome) and the association of AMD with dementia/AD (as outcome). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313277DOI Listing

Anatomical and functional changes in neovascular AMD in remission: comparison of fibrocellular and fibrovascular phenotypes.

Br J Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Department of Ophthalmology, University Vita Salute, Hospital San Raffaele, Milano, Italy

Purpose: To investigate the anatomical changes and the macular function in neovascular age-related macular degeneration (AMD) eyes, according to the recognition of either fibrocellular or fibrovascular phenotype.

Methods: We enrolled eyes with previously treated neovascular AMD in remission (no subretinal haemorrhage, sign of fluid in or under the retina and no treatment for at least 6 months). Subjects underwent multimodal imaging assessment and were tested for macular sensitivity using microperimetry. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313685DOI Listing

Combined subconjunctival injection of dexamethasone for the management of acute primary angle closure: a randomised controlled trial.

Br J Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, China

Purpose: To investigate whether the combined subconjunctival injection of dexamethasone can accelerate the decrease in intraocular pressure (IOP) in acute primary angle closure (APAC)-affected eyes.

Methods: 42 patients with APAC were recruited for a randomised controlled trial. These patients were separated into two groups: the injection group (21 patients) and the control group (21 patients). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313473DOI Listing

Expression of prostaglandin E receptor 3 in the eyelid epidermis of patients with Stevens-Johnson syndrome/toxic epidermal necrolysis.

Br J Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Background/aims: In a previous genome-wide association study of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) patients we reported the association between SJS/TEN and the prostaglandin E receptor 3 (PTGER3) gene, and that its protein PGE receptor 3 (EP3) was markedly downregulated in the conjunctival epithelium of SJS/TEN patients. Here we examined EP3 expression of the eyelid epidermis in SJS/TEN patients with severe ocular complications and investigated the function of EP3.

Methods: For the immunohistochemical study, we obtained eyelid samples from five SJS/TEN patients and five patients without SJS/TEN (control subjects) who were undergoing surgery to treat trichiasis, and investigated the expression of EP3 protein in the epidermis of those samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313587DOI Listing

Effects of three intravitreal injections of aflibercept on the ocular circulation in eyes with age-related maculopathy.

Br J Ophthalmol 2019 Apr 12. Epub 2019 Apr 12.

Department of Ophthalmology, Kepler University Hospital, Linz, Austria

Aims: To investigate changes in ocular perfusion following three consecutive intravitreal injections with aflibercept for treatment of neovascular age-related macular degeneration (nAMD).

Methods: The study included 20 eyes from 20 Caucasian patients with unilateral nAMD and 20 fellow eyes. All nAMD eyes were treated with standard intravitreal injection of aflibercept (IVA; 2 mg). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2019-313919DOI Listing

Detailed clinical characterisation, unique features and natural history of autosomal recessive -associated retinal degeneration.

Br J Ophthalmol 2019 Apr 12. Epub 2019 Apr 12.

Moorfields Eye Hospital NHS Foundation Trust, London, UK.

Background: Defects in retinol dehydrogenase 12 () account for 3.4%-10.5 % of Leber congenital amaurosis and early-onset severe retinal dystrophy (EOSRD) and are a potential target for gene therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313580DOI Listing

Comparison of anterior capsulotomy techniques: continuous curvilinear capsulorhexis, femtosecond laser-assisted capsulotomy and selective laser capsulotomy.

Br J Ophthalmol 2019 Apr 4. Epub 2019 Apr 4.

Excel-Lens Inc, Livermore, California, USA.

Purpose: To compare the anterior capsulotomy edge tear strength created by manual continuous curvilinear capsulorhexis (CCC), femtosecond laser-assisted capsulotomy (FLACS), and selective laser capsulotomy (SLC).

Setting: Singapore National Eye Centre, Singapore and Excel-Lens, Livermore, California, USA.

Design: Three armed study in paired human eyes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313421DOI Listing
April 2019
1 Read

Effect of recombinant human nerve growth factor eye drops in patients with dry eye: a phase IIa, open label, multiple-dose study.

Br J Ophthalmol 2019 Apr 3. Epub 2019 Apr 3.

Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.

Background: Dry eye disease (DED) affects more than 14% of the elderly population causing decrease of quality of life, high costs and vision impairment. Current treatments for DED aim at lubricating and controlling inflammation of the ocular surface. Development of novel therapies targeting different pathogenic mechanisms is sought-after. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-312470DOI Listing

Exploring patients' expectations and preferences of glaucoma surgery outcomes to facilitate healthcare delivery and inform future glaucoma research.

Br J Ophthalmol 2019 Apr 3. Epub 2019 Apr 3.

Department of Ophthalmology, Queen's Medical Centre, Nottingham, UK

Introduction: Glaucoma is a lifelong condition often requiring surgical intervention. To allow us to inform patients' expectations of surgery effectively, it is important to understand patients' preferences and concerns regarding outcomes from glaucoma treatments including surgery.

Aims: To explore what clinical and social outcomes of glaucoma surgery are important to patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313401DOI Listing

Genetic aspects of idiopathic paediatric uveitis and juvenile idiopathic arthritis associated uveitis in Chinese Han.

Br J Ophthalmol 2019 Apr 2. Epub 2019 Apr 2.

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, P. R. China

Background: Idiopathic paediatric uveitis (IPU) and juvenile idiopathic arthritis associated uveitis (JIA-U) are the two most common entities in paediatric uveitis. This study addressed the possible association of IPU and JIA-U with genes that had been shown earlier to be associated with juvenile idiopathic arthritis.

Methods: We carried out a case-control association study involving 286 IPU, 134 JIA-U patients and 743 healthy individuals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313200DOI Listing
April 2019
1 Read

Vimentin overexpression as a novel poor prognostic biomarker in eyelid sebaceous gland carcinoma.

Br J Ophthalmol 2019 Apr 2. Epub 2019 Apr 2.

Department of Ocular Pathology, All India Institute of Medical Sciences, New Delhi, India.

Background: Vimentin is an intermediate-sized filament which is highly expressed in mesenchymal cells and is associated with epithelial-mesenchymal transition (EMT). EMT markers ZEB2 and Slug lead to Vimentin overexpression and E-cadherin loss, resulting in invasion and metastasis. However, the status of Vimentin remains unexplored in eyelid sebaceous gland carcinoma (SGC). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313285DOI Listing

Topographic correlation between macular superficial microvessel density and ganglion cell-inner plexiform layer thickness in glaucoma-suspect and early normal-tension glaucoma.

Br J Ophthalmol 2019 Apr 2. Epub 2019 Apr 2.

Department of Ophthalmology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea

Background/aims: To investigate the topographic relationship between macular superficial microvessel density (SMD) and macular ganglion cell-inner plexiform layer (GCIPL) thickness in eyes with glaucoma-suspect (GS) and early normal-tension glaucoma (NTG).

Methods: A total of 86 eyes of 86 patients with early NTG (standard automated perimetry mean deviation >-5.5 decibels) and a total of 25 eyes of 25 patients with GS were retrospectively reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313732DOI Listing
April 2019
1 Read
2.976 Impact Factor

Tear cytokine profiling in patients with superior limbic keratoconjunctivitis who underwent medical treatment or in conjunction with surgical management.

Br J Ophthalmol 2019 Mar 29. Epub 2019 Mar 29.

Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan

Purpose: To determine the correlation between superior limbic keratoconjunctivitis (SLK) and selected tear cytokines and to evaluate the efficacy of these cytokines in monitoring the response of patients with SLK to either medical treatment alone or in combination with conjunctival resection.

Design: A cohort study.

Methods: Twenty-five eyes of 13 patients with SLK were assigned to either medically responsive or surgical treatment groups depending on their responses 1 month after initial medical treatment. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313358DOI Listing

Corneal biomechanics and biomechanically corrected intraocular pressure in primary open-angle glaucoma, ocular hypertension and controls.

Br J Ophthalmol 2019 Mar 28. Epub 2019 Mar 28.

Biomedical Sciences Research Institute, University of Ulster, Coleraine, UK.

Aims: To compare the biomechanically corrected intraocular pressure (IOP) estimate (bIOP) provided by the Corvis-ST with Goldmann applanation tonometry (GAT-IOP) in patients with high-tension and normal-tension primary open-angle glaucoma (POAG; HTG and NTG), ocular hypertension (OHT) and controls. Moreover, we compared dynamic corneal response parameters (DCRs) of the Corvis-ST in POAG, OHT and controls, evaluated the correlation between global visual field parameters mean deviation and pattern SD (MD and PSD) and DCRs in the POAG group.

Methods: 156 eyes of 156 patients were included in this prospective, single-centre, observational study, namely 41 HTG and 33 NTG, 45 OHT cases and 37 controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313493DOI Listing
March 2019
3 Reads

Risk factors and outcomes of management of delayed suprachoroidal haemorrhage following Ahmed glaucoma valve implantation in children.

Br J Ophthalmol 2019 Mar 28. Epub 2019 Mar 28.

Smt Jadhavabhai Nathmal Singhvee Glaucoma Services, Medical Research Foundation, Sankara Nethralaya, Chennai, India.

Aims: To assess the incidence, risk factors and outcomes of management of delayed suprachoroidal haemorrhage (DSCH) in children who had undergone Ahmed glaucoma valve implantation.

Methods: A retrospective case-control study of eyes which developed DSCH in children <18 years of age who underwent surgery between January 2009 and December 2017 with a follow-up of at least 2 months was performed. Nine cases were compared with 27 age, gender and surgeon matched controls who had undergone surgery during this period. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313804DOI Listing
March 2019
2 Reads

Retinal findings in carriers of monoallelic mutations.

Br J Ophthalmol 2019 Mar 28. Epub 2019 Mar 28.

Department of Ophthalmology, University of Bonn, Bonn, Germany

Aim: Biallelic mutations cause pseudoxanthoma elasticum, a systemic disease characterised by calcification of elastic tissue and a specific retinal phenotype. In this study, we investigated if monoallelic mutations are also associated with retinal alterations.

Methods: In this prospective, cross-sectional, monocentre case-control study, carriers of monoallelic mutations were investigated and compared with age-matched controls. Read More

View Article

Download full-text PDF

Source
http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3134
Publisher Site
http://dx.doi.org/10.1136/bjophthalmol-2018-313448DOI Listing
March 2019
2 Reads

Correlation of changes in serum level of VEGF and peripapillary retinal thickness in patients with POEMS syndrome.

Br J Ophthalmol 2019 Mar 26. Epub 2019 Mar 26.

Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, Japan.

Aim: To determine whether changes in the serum levels of vascular endothelial growth factor (VEGF) after thalidomide therapy will affect the peripapillary retinal thickness (pRT) associated with optic disc oedema (ODE) in patients with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes (POEMS) syndrome.

Methods: This was a retrospective, observational case series of 23 right eyes of 23 treatment-naïve patients with POEMS syndrome and ODE whose intracranial pressure was within the normal range. The pRT was determined by spectral-domain optical coherence tomography, and the serum level of VEGF was determined by ELISA at baseline and 6 months after the thalidomide therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313703DOI Listing
March 2019
1 Read

National Eye Survey of Trinidad and Tobago (NESTT): prevalence, causes and risk factors for presenting vision impairment in adults over 40 years.

Br J Ophthalmol 2019 Mar 26. Epub 2019 Mar 26.

Vision and Eye Research Unit, Anglia Ruskin University, Cambridge, UK.

Aim: To estimate the prevalence, causes and risk factors for presenting distance and near vision impairment (VI) in Trinidad and Tobago.

Methods: This is a national, population-based survey using multistage, cluster random sampling in 120 clusters with probability-proportionate-to-size methods. Stage 1 included standardised, community-based measurement of visual acuity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313428DOI Listing
March 2019
2.976 Impact Factor

Exogenous influences on intraocular pressure.

Br J Ophthalmol 2019 Mar 25. Epub 2019 Mar 25.

Ophthalmology, Seoul National University College of Medicine, Seoul, Republic of Korea

Intraocular pressure (IOP), the pressure within the eyeball, is a function mainly of the production and elimination of aqueous humour. Balanced IOP helps to maintain the eyeball contour, allowing proper refraction of light in the anterior segment of the eye. Increases in IOP can cause injury to the ocular structure, typically the optic nerve head and retinal ganglion cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313381DOI Listing
March 2019
2.976 Impact Factor

Release of silicone oil and the off-label use of syringes in ophthalmology.

Br J Ophthalmol 2019 Mar 25. Epub 2019 Mar 25.

Ophthalmology, Federal University of São Paulo, São Paulo, Brazil.

Background/aims: To assess silicone oil (SO) release by different brands of syringes used for intravitreal injection under different handling conditions.

Methods: Eight syringes were analysed: from the USA, Terumo 0.5 mL, Becton-Dickinson (BD) Tuberculin 1 mL, BD Luer-lok 1 mL, BD Ultra-Fine 0. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2019-313823DOI Listing

Ruthenium-106 versus iodine-125 plaque brachytherapy of 571 choroidal melanomas with a thickness of ≥5.5 mm.

Br J Ophthalmol 2019 Mar 25. Epub 2019 Mar 25.

St. Erik Eye Hospital, Stockholm, Sweden

Background: Episcleral brachytherapy is the most common eye-preserving treatment for medium-sized choroidal melanomas. γ-emitting iodine-125 (I) and β-emitting ruthenium-106 (Ru) are widely used. The latter is however generally reserved for thinner tumours (<6 mm). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313419DOI Listing

Differences in ocular biometrics and aqueous humour dynamics between Chinese and Caucasian adults.

Br J Ophthalmol 2019 Mar 20. Epub 2019 Mar 20.

Ophthalmology, University of Nebraska Medical Center, Omaha, Nebraska, USA

Background: Glaucoma prevalence and subtype profile vary across different racial and ethnic groups. This study provides a comparative evaluation of differences in aqueous humour dynamics (AHD) and ocular biometrics in healthy Chinese and Caucasian adults of two different age groups.

Methods: Data from two independent studies with identical designs were compared. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313132DOI Listing

Extensive circumferential partial-thickness sclerectomy in eyes with extreme nanophthalmos and spontaneous uveal effusion.

Br J Ophthalmol 2019 Mar 15. Epub 2019 Mar 15.

Ophthalmology, American University of Beirut, Beirut, Lebanon.

Aim: To describe an extensive scleral excision technique to treat uveal effusion in nanophthalmic eyes.

Methods: This prospective, interventional series of eight eyes of five consecutive patients with nanophthalmos underwent scleral window surgeries. Ninety per cent of the scleral thickness, extending from immediately behind the extraocular muscle insertions to the vortex veins for 3 and 1/4 quadrants, was removed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313702DOI Listing
March 2019
1 Read

BTNL2 gene polymorphism and sarcoid uveitis.

Br J Ophthalmol 2019 Mar 14. Epub 2019 Mar 14.

Internal Medicine, University Claude Bernard, Lyon, France

Background: Uveitis is a frequent and early feature of sarcoidosis. As BTNL2 (butyrophilin-like 2) gene polymorphism was found linked with the susceptibility to sarcoidosis, we investigated whether a specific genotype of BTNL2 gene G16071A (or rs2076530) single-nucleotide polymorphism (SNP) would be associated with the risk of sarcoid uveitis in all patient subgroups.

Methods: The study compared the genotype frequencies of SNP G16071A of 135 patients with sarcoid uveitis (SaUv) with those of 196 patients with sarcoidosis without uveitis (SaUv), 81 patients with uveitis without sarcoidosis (SaUv), and 271 controls with no sarcoidosis nor uveitis (SaUv). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-312949DOI Listing
March 2019
2 Reads

Analysis of quantitative correlations between microaneurysm, ischaemic index and new vessels in ultrawide-field fluorescein angiography images using automated software.

Br J Ophthalmol 2019 Mar 14. Epub 2019 Mar 14.

Ophthalmology, Asan Medical Center, University of Ulsan, Seoul, Republic of Korea

Background/aim: To analyse ultrawide-field fluorescein angiography (UWF-FA) images of diabetic retinopathy using a novel software that automatically calculates microaneurysm (MA) and non-perfusion area.

Methods: Two hundred UWF-FA images of treatment-naïve diabetic retinopathy (38 proliferative diabetic retinopathy and 162 non-proliferative diabetic retinopathy) from 120 patients (mean age 54.22; 80 male) were analysed using novel software to determine the number of MAs, area of capillary non-perfusion (ischaemic index) and number of neovascularisations. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313596DOI Listing
March 2019
4 Reads

Risk factors for incident central serous retinopathy: case-control analysis of a US national managed care population.

Br J Ophthalmol 2019 Mar 14. Epub 2019 Mar 14.

Stanford University School of Medicine, Stanford, California, USA

Aim: To evaluate clinical comorbidities and steroid use as risk factors for central serous retinopathy (CSR).

Methods: Using national insurance databases, we conducted a case-control study of beneficiaries with an incident diagnosis of CSR between 2007 and 2015 (n=35 492) and randomly selected controls matched on age-based and sex-based propensity scores (n=1 77 460).

Results: The mean age (SD) of cases was 49. Read More

View Article

Download full-text PDF

Source
http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3130
Publisher Site
http://dx.doi.org/10.1136/bjophthalmol-2018-313050DOI Listing
March 2019
4 Reads

Examinations under anaesthesia as a measure of disease burden in unilateral retinoblastoma: the London experience.

Br J Ophthalmol 2019 Mar 12. Epub 2019 Mar 12.

Moorfields Eye Hospital, London, UK.

Background: Early diagnosis strategies and advances in retinoblastoma (Rb) management have resulted in nearly 100% survival. More attention should, therefore, be given to quality of life considerations. We aimed to quantify the number of examinations under anaesthesia (EUAs) in a cohort of patients with Rb, as a measure of disease burden. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313556DOI Listing
March 2019
3 Reads

Long-term efficacy and tolerability of TNFα inhibitors in the treatment of non-infectious ocular inflammation: an 8-year prospective surveillance study.

Br J Ophthalmol 2019 Mar 12. Epub 2019 Mar 12.

National Institute of Health Research, Biomedical Research Centre in Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.

Background/aim: To report the efficacy and tolerability of antitumour necrosis factor-alpha therapy (TNF inhibitors [TNFi]) in the management of non-infectious ocular inflammation, including uveitis and scleritis, in adult patients over an 8-year period.

Materials And Methods: This is a prospective cohort study of infliximab and adalimumab in the treatment of non-infectious ocular inflammatory disease. 43 of 85 adult patients on TNFi (34 infliximab, 9 adalimumab) for ≥1 year with non-infectious uveitis or scleritis were followed from 2006 to 2014. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-312767DOI Listing
March 2019
2.976 Impact Factor

SNP located in an repeat downstream of rs4657473, is protective for POAG in African Americans.

Br J Ophthalmol 2019 Mar 12. Epub 2019 Mar 12.

Ophthalmology, Scheie Eye Institute, Philadelphia, Pennsylvania, USA.

Aims: To determine the association of single nucleotide polymorphisms (SNPs) downstream from the gene with primary open-angle glaucoma (POAG) in African Americans (AA).

Methods: AA subjects were recruited for the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study from the Scheie Eye Institute and its satellite sites in Philadelphia. A region containing an repeat and seven SNPs, including rs4656461 near the gene, were PCR-Sanger sequenced from POAAGG cases (n=1537) and controls (n=1570). Read More

View Article

Download full-text PDF

Source
http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3130
Publisher Site
http://dx.doi.org/10.1136/bjophthalmol-2018-313086DOI Listing
March 2019
4 Reads

Factors influencing the outcome of goniotomy and trabeculotomy in primary congenital glaucoma.

Br J Ophthalmol 2019 Mar 7. Epub 2019 Mar 7.

Ophthalmology department, Kasr Al Ainy Faculty of Medicine, Cairo University, Cairo, Egypt.

Purpose: To study the prognostic factors influencing intraocular pressure (IOP) reduction and success rates of paediatric goniotomy and trabeculotomy.

Patients: Data from patients aged ≤12 years who underwent goniotomy or trabeculotomy for primary congenital glaucoma from 2013 to 2016 were reviewed. The analysis included 452 eyes of which 120 eyes of patients with a median age (IQR) of 6 months (4. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313387DOI Listing
March 2019
1 Read

Proteomic analysis of the aqueous humour in eyes with pseudoexfoliation syndrome.

Br J Ophthalmol 2019 Mar 6. Epub 2019 Mar 6.

Analytical Chemistry and Neurochemistry, Department of Chemistry-BMC, Uppsala University, Uppsala, Sweden

Background/aims: Pseudoexfoliation syndrome (PEX) is characterised by the production and accumulation of extracellular fibrillar material in the anterior segment of the eye. The pathogenesis of PEX is multifactorial with genetic factors and ageing as contributing factors. Previously, an increased concentration of beta-crystalline B2 (CRYBB2) was observed in the aqueous humour (AH) in eyes with PEX in a pooled material. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2017-310416DOI Listing

Swept source optical coherence tomography angiography in patients treated with hydroxychloroquine: correlation with morphological and functional tests.

Br J Ophthalmol 2019 Mar 6. Epub 2019 Mar 6.

Retina and Vitreous Department, Institut Catala de Retina, Barcelona, Spain.

Purpose: To evaluate swept source optical coherence tomography angiography (SS-OCTA) in patients treated with hydroxychloroquine (HCQ) for more than 5 years and to compare results with the tests currently recommended for screening of HCQ retinopathy.

Methods: In this controlled pilot study, consecutive patients treated with HCQ for more than 5 years underwent SS-OCTA, SS-OCT B-scan and en-face C-scan, fundus autofluorescence (FAF), 10-2 automated visual field (AVF) testing and multifocal electroretinography (mfERG). On SS-OCTA, evaluation of the retinal superficial capillary plexus, middle capillary plexus, and deep capillary plexus (DCP) and the choriocapillaris (CC) was obtained. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313679DOI Listing
March 2019
1 Read

Validation of a model for the prediction of retinopathy in persons with type 1 diabetes.

Br J Ophthalmol 2019 Mar 1. Epub 2019 Mar 1.

Department of General Practice and Elderly Care Medicine, Amsterdam Public Health Research Institute, VU Medical Centre, Amsterdam, The Netherlands.

Background/aim: To validate a previously developed model for prediction of diabetic retinopathy (DR) for personalised retinopathy screening in persons with type 1 diabetes.

Methods: Retrospective medical data of persons with type 1 diabetes treated in an academic hospital setting were used for analysis. Sight-threatening retinopathy (STR) was defined as the presence of severe non-proliferative DR, proliferative DR or macular oedema. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313539DOI Listing
March 2019
3 Reads

Uveal melanoma incidence trends in Canada: a national comprehensive population-based study.

Br J Ophthalmol 2019 Feb 28. Epub 2019 Feb 28.

Division of Dermatology, McGill University Health Centre, Montreal, Québec, Canada

Background: In the developed countries, uveal melanoma is the most common primary intraocular malignancy in adults. Little is known about the epidemiological and geographical distribution of uveal melanoma in Canada.

Methods: To determine the incidence patterns and geographical distribution of uveal melanoma cases in Canada, we conducted the first comprehensive, population-based national study of this malignancy across all Canadian provinces and territories during 1992-2010 years. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-312966DOI Listing
February 2019

Early hydroxychloroquine retinopathy: optical coherence tomography abnormalities preceding Humphrey visual field defects.

Br J Ophthalmol 2019 Feb 28. Epub 2019 Feb 28.

David Geffen School of Medicine at UCLA, University of California Los Angeles, Stein Eye Institute, Los Angeles, California, USA

Background/aims: Hydroxychloroquine (HCQ) retinopathy may result in severe and irreversible vision loss, emphasising the importance of screening and early detection. The purpose of this study is to report the novel finding of early optical coherence tomography (OCT) abnormalities due to HCQ toxicity that may develop in the setting of normal Humphrey visual field (HVF) testing.

Methods: Data from patients with chronic HCQ exposure was obtained from seven tertiary care retina centres. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313350DOI Listing
February 2019
1 Read

Darkroom prone provocative testing in primary angle closure suspects and those with open angles.

Br J Ophthalmol 2019 Feb 28. Epub 2019 Feb 28.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Purpose: To describe the results of darkroom prone provocative testing (DRPPT) in primary angle closure suspects (PACS) and to compare the findings to controls with open angles.

Methods: 889 subjects with PACS in the Zhongshan Angle Closure Prevention Trial (a randomised controlled trial to compare prophylactic laser iridotomy to no treatment in PACS) and 89 with open angles in the 5-year follow-up of Liwan Eye Study were placed in a darkroom face down for 15 min. Intraocular pressure (IOP) was measured immediately before and after DRPPT. Read More

View Article

Download full-text PDF

Source
http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3133
Publisher Site
http://dx.doi.org/10.1136/bjophthalmol-2018-313362DOI Listing
February 2019
4 Reads

Prospective randomised clinical trial of intravitreal bevacizumab versus triamcinolone in eyes with diabetic macular oedema undergoing cataract surgery: 6-month results.

Br J Ophthalmol 2019 Feb 28. Epub 2019 Feb 28.

Department of Surgery (Ophthalmology), Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, East Melbourne, Victoria, Australia

Aim: To report the 6-month results of a clinical trial that compared intravitreous bevacizumab (BVB) 1.25 mg versus triamcinolone acetonide (TA) 4 mg when administered as an adjunct during cataract surgery to patients with diabetic macular oedema (DMO).

Methods: Prospective, double-masked, single-centre (Royal Victorian Eye and Ear Hospital, Melbourne) clinical trial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313437DOI Listing
February 2019
1 Read

Right-angled vessels in macular telangiectasia type 2.

Br J Ophthalmol 2019 Feb 26. Epub 2019 Feb 26.

Department of Ophthalmology, University Hospital Bonn, Bonn, Germany.

Purpose: To evaluate the role of right-angled vessels (RAVs) during disease progression in macular telangiectasia type 2 (MacTel).

Methods: In this study, 100 eyes of 52 patients and 52 eyes of 26 age-related controls were examined using fundus photography, spectral-domain optical coherence tomography (SD-OCT), OCT angiography (OCT-A) and fundus fluorescein angiography (FFA). Two masked readers graded fundus photographs of patients' eyes into five disease stages according to Gass and Blodi, and evaluated all eyes for the presence of RAVs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313364DOI Listing
February 2019

Revised criteria of International Workshop on Ocular Sarcoidosis (IWOS) for the diagnosis of ocular sarcoidosis.

Br J Ophthalmol 2019 Feb 23. Epub 2019 Feb 23.

Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.

Aims: International criteria for the diagnosis of ocular sarcoidosis (OS) was established by the first International Workshop on Ocular Sarcoidosis (IWOS) and validations studies revealed certain limitations of the criteria. To overcome the limitations, revised IWOS criteria was established in an international meeting. This manuscript was aimed at reporting the revised IWOS criteria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313356DOI Listing
February 2019
1 Read

Calcification of hydrophilic acrylic intraocular lenses following secondary surgical procedures in the anterior and posterior segments.

Br J Ophthalmol 2019 Feb 23. Epub 2019 Feb 23.

Ophthalmology, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia

Aims: To report 15 cases of intraocular lens (IOL) calcification following intraocular surgery and to identify common risk factors.

Methods: A retrospective case review of patients with IOL calcification reported from the Royal Victorian Eye and Ear Hospital, Melbourne, Australia, and six surgeons in private practice in the Australian states of Victoria, New South Wales and Queensland.

Results: 15 cases of IOL calcification were identified. Read More

View Article

Download full-text PDF

Source
http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3133
Publisher Site
http://dx.doi.org/10.1136/bjophthalmol-2018-313385DOI Listing
February 2019
11 Reads

Comparison between manual trephination versus femtosecond laser-assisted deep anterior lamellar keratoplasty for keratoconus.

Br J Ophthalmol 2019 Feb 23. Epub 2019 Feb 23.

Poostchi Ophthalmology Research Center, Department of Ophthalmology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Background/aims: To compare the outcomes of femtosecond laser-assisted deep anterior lamellar keratoplasty (F-DALK) versus manual trephination DALK (M-DALK) in patients with keratoconus.

Methods: In this retrospective, comparative, clinical study, medical charts of 860 patients with keratoconus who underwent F-DALK (n=391) or M-DALK (n=469) with the Melles's technique, and had at least a 12-month follow-up record were reviewed. The main outcome measures comprised best spectacle-corrected visual acuity (BSCVA), manifest refraction and keratometric indices. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313365DOI Listing
February 2019
1 Read

Optical coherence tomography angiography findings in fellow eyes of choroidal neovascularisation associated with central serous chorioretinopathy.

Br J Ophthalmol 2019 Feb 23. Epub 2019 Feb 23.

Smt. Kanuri Santhamma Centre for Vitreo-Retinal Diseases, L V Prasad Eye Institute, Hyderabad, Telangana, India

Aim: To evaluate the optical coherence tomography angiography (OCTA) features of fellow eyes of patients with unilateral choroidal neovascularisation (CNV) associated with chronic central serous chorioretinopathy (CSCR).

Methods: Medical records of patients with chronic CSCR who had undergone OCT angiography of both the eyes were reviewed. Patients with evidence of unilateral CNV detected by conventional imaging (OCT, fluorescein angiography and/or indocyanine green angiography) were included in the study. Read More

View Article

Download full-text PDF

Source
http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3135
Publisher Site
http://dx.doi.org/10.1136/bjophthalmol-2018-313576DOI Listing
February 2019
2 Reads

Retinal vessel oxygen saturation is affected in uveitis associated with Vogt-Koyanagi-Harada disease.

Br J Ophthalmol 2019 Feb 23. Epub 2019 Feb 23.

Department of Physiology, University of Iceland, Reykjavik, Iceland.

Aims: To discover whether retinal vessel oxygen metabolism is affected in uveitis associated with Vogt-Koyanagi-Harada (VKH) disease.

Methods: 41 patients with VKH disease (82 eyes) and 12 healthy subjects (24 eyes) matched in age and gender were prospectively evaluated. Retinal oxygen saturation and vessel calibre were measured with a non-invasive spectrophotometric retinal oximeter (Oxymap T1). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313719DOI Listing
February 2019
1 Read

Does daily dietary intake affect diabetic retinopathy progression? 10-year results from the 45 and Up Study.

Br J Ophthalmol 2019 Feb 22. Epub 2019 Feb 22.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China

Background/aims: To evaluate the associations of dietary consumption with the 10-year incidence of diabetic retinopathy (DR) progression in working-aged Australians with diabetes.

Methods: We obtained longitudinal data of all diabetic subjects aged 45-65 years from the baseline of the 45 and Up Study and linked this data with Medicare Benefits Schedule (MBS) and Pharmaceutical Benefits Scheme claims until 2016. Retinal photocoagulation (RPC), as determined based on the MBS data, was used as a proxy measure of DR progression. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-312990DOI Listing
February 2019
4 Reads
2.976 Impact Factor

Preservation of retinoblastoma group E eyes with neovascular glaucoma using intravenous chemotherapy: risk factors and outcomes.

Br J Ophthalmol 2019 Feb 22. Epub 2019 Feb 22.

Ocular Oncology Service, Centre for Sight, Hyderabad, India.

Background/aim: To report the outcomes of retinoblastoma group E eyes with neovascular glaucoma (NVG) treated conservatively with intravenous chemotherapy and investigate factors associated with eye salvage and secondary enucleation.

Methods: This is a retrospective, comparative, interventional case series. The outcome measures were life salvage, eye salvage and vision salvage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313442DOI Listing
February 2019
2 Reads

Modified Goldmann prism intraocular pressure measurement accuracy and correlation to corneal biomechanical metrics: multicentre randomised clinical trial.

Br J Ophthalmol 2019 Feb 22. Epub 2019 Feb 22.

Arizona Eye Consultants, Tucson, Arizona, USA.

Purpose: Clinically evaluate intraocular pressure (IOP) measurements taken with a Goldmann applanation tonometer (GAT) prism and a modified surface Goldmann prism examining measurement differences correlated to central corneal thickness (CCT) and corneal hysteresis (CH) values.

Design: Prospective, open-label, randomised, controlled, multicentre reference device accuracy analysis.

Methods: A GAT and a modified surface GAT prism measured IOP on 243 unique eyes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313470DOI Listing
February 2019

Individualisation of glaucoma quality of life measures: a way forward?

Br J Ophthalmol 2019 Mar;103(3):293-295

Centre for Public Health, Queen's University Belfast, Belfast, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2019-313873DOI Listing

Decreased contrast sensitivity at high altitude.

Br J Ophthalmol 2019 Feb 15. Epub 2019 Feb 15.

Department of Ophthalmology, Katharinenhospital Stuttgart, Stuttgart, Germany

Background/aims: The aim of this study was to investigate a change in visual acuity and contrast sensitivity (CS) during high altitude exposure in healthy subjects due to the effects of hypobaric hypoxia. This study is related to the Tübingen High Altitude Ophthalmology study.

Methods: Visual acuity and Weber CS were tested monocularly using the Freiburger Visual Acuity and Contrast Test under standardised conditions in 14 healthy subjects at high altitude at the Capanna Margherita (4559 m, Italy) and compared with baseline measurements in Tübingen (341 m, Germany). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bjophthalmol-2018-313260DOI Listing
February 2019
1 Read