Search our Database of Scientific Publications and Authors

I’m looking for a

    19763 results match your criteria British Journal of Ophthalmology[Journal]

    1 OF 396

    Impact of type I Boston keratoprosthesis implantation on vision-related quality of life.
    Br J Ophthalmol 2017 Sep 19. Epub 2017 Sep 19.
    Moorfields Eye Hospital, London, UK.
    Aim: To determine the impact of type I Boston keratoprosthesis (KPro) implantation on vision-related quality of life (VRQoL).

    Methods: Prospective study in 33 patients (mean age 56±12 years, 67% male) with bilateral corneal blindness, who underwent a KPro implantation at a single tertiary eye hospital (June 2011-July 2015). VRQoL was evaluated using the Impact of Vision Impairment Questionnaire (IVI) at baseline and at 3-6 months postsurgery, after stabilisation of best-corrected visual acuity (BCVA). Read More

    Inter-relationship between visual symptoms, activity limitation and psychological functioning in patients with diabetic retinopathy.
    Br J Ophthalmol 2017 Sep 19. Epub 2017 Sep 19.
    Centre for Eye Research Australia, University of Melbourne, the Royal Victorian Eye and Ear Hospital, Melbourne, VIC, Australia.
    Aims: We explored the direct and indirect impact of restrictions in daily living activities on the relationship between perceived visual symptoms associated with diabetic retinopathy (DR) and psychological functioning.

    Methods: In this prospective, cross-sectional study, 514 tertiary patients with DR (mean age±SD, 60.4±12. Read More

    Outcomes of lensectomy and risk factors for failure in spherophakic eyes with secondary glaucoma.
    Br J Ophthalmol 2017 09 19. Epub 2017 Sep 19.
    VST Centre for Glaucoma, L V Prasad Eye Institute, Hyderabad, India.
    Purpose: To report the outcomes of lensectomy in spherophakic eyes with subluxated or dislocated crystalline lenses and secondary glaucoma.

    Methods: Lensectomy was performed in 52 eyes, 36 eyes with lens subluxation and 16 eyes with lens dislocation with secondary glaucoma from 1991 to 2016. Glaucoma was diagnosed based on intraocular pressure (IOP) ≥22 mm Hg and/or glaucomatous optic disc damage. Read More

    Role of ultrasound biomicroscopy in diagnosis of ocular toxocariasis.
    Br J Ophthalmol 2017 Sep 19. Epub 2017 Sep 19.
    Department of Ophthalmology, Fudan University Eye and ENT Hospital, Fudan University, Shanghai, China.
    Purpose: To investigate ultrasound biomicroscopy (UBM) characteristics of patients with ocular toxocariasis (OT) and to explore the role of UBM in the diagnosis and differential diagnosis of OT.

    Design: Cross-sectional study.

    Methods: 78 eyes of 77 patients clinically consistent with OT and confirmed by serum and/or intraocular antibodies in a single tertiary centre (Fudan University Eye and ENT Hospital, Shanghai) between July 2009 and July 2016 were included in the study. Read More

    Long-term follow-up of benign positional vertical opsoclonus in infants: retrospective cohort.
    Br J Ophthalmol 2017 Sep 13. Epub 2017 Sep 13.
    Department of Ophthalmology, Bnai Zion Medical Center, Haifa, Israel.
    Background/aims: Benign positional vertical opsoclonus in infants, also described as paroxysmal tonic downgaze, is an unsettling phenomenon that leads to extensive work-up, although benign course has been reported in sporadic cases. We describe long-term follow-up of a series of infants with the phenomenon.

    Methods: This retrospective cohort included all infants diagnosed with rapid downgaze eye movement in 2012-2015 and followed until 2016. Read More

    Laser in Glaucoma and Ocular Hypertension (LiGHT) Trial. A multicentre, randomised controlled trial: design and methodology.
    Br J Ophthalmol 2017 Sep 13. Epub 2017 Sep 13.
    NIHR Biomedical Research Centre at Moorfields , Eye Hospital NHS Foundation Trust, London, UK.
    Purpose: The Laser in Glaucoma and Ocular Hypertension (LiGHT) Trial aims to establish whether initial treatment with selective laser trabeculoplasty (SLT) is superior to initial treatment with topical medication for primary open-angle glaucoma (POAG) or ocular hypertension (OHT).

    Design: The LiGHT Trial is a prospective, unmasked, multicentre, pragmatic, randomised controlled trial. 718 previously untreated patients with POAG or OHT were recruited at six collaborating centres in the UK between 2012 and 2014. Read More

    Enteric-coated mycophenolate sodium in the treatment of non-infectious intermediate uveitis: results of a prospective, controlled, randomised, open-label, early terminated multicentre trial.
    Br J Ophthalmol 2017 Sep 13. Epub 2017 Sep 13.
    Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany.
    Background/aims: To evaluate the efficacy, safety and tolerability of enteric-coated mycophenolate sodium (EC-MPS) in combination with low-dose corticosteroids compared with a monotherapy with low-dose corticosteroids in subjects with non-infectious intermediate uveitis (IU).

    Methods: Open-label, prospective, controlled, randomised multicentre trial. Patients were randomised in a 1:1 ratio to either the treatment group (prednisolone plus EC-MPS) or control group (prednisolone monotherapy). Read More

    Clinical profile of pythium keratitis: perioperative measures to reduce risk of recurrence.
    Br J Ophthalmol 2017 Sep 13. Epub 2017 Sep 13.
    L&T Microbiology Research Centre, Vision Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India.
    Purpose: To report the clinical profile and role of perioperative adjunctive measures to reduce the risk of recurrence in Pythium insidiosum keratitis.

    Methods: Retrospective analysis of 10 eyes of 10 patients with P. insidiosum keratitis. Read More

    Predictors of radio-induced visual impairment after radiosurgery for uveal melanoma.
    Br J Ophthalmol 2017 Sep 13. Epub 2017 Sep 13.
    Department of Medical Physics, San Raffaele Scientific Institute, Milano, Italy.
    Aims: The aim of the present work is to assess the main predictors of the most clinically relevant radio-induced effects after Gamma Knife stereotactic radiosurgery (GKRS) for uveal melanoma (UM).

    Materials And Methods: Medical records and three-dimensional dosimetry data of critical structures of 66 patients were retrospectively reviewed. Cox's proportional hazard model was used to identify clinical and dosimetric variables as independent risk factor for GKRS-related complications. Read More

    An evaluation of intracameral mydriasis for routine cataract surgery.
    Br J Ophthalmol 2017 Sep 13. Epub 2017 Sep 13.
    Eye Unit, Salisbury District Hospital, Salisbury, UK.
    Background: Intracameral Mydrane might facilitate a more streamlined cataract service and improve the patient experience. There is limited 'real-world' evidence of its use in a UK setting.

    Methods: As part of a local evaluation of cataract surgery using intracameral Mydrane (group 2; n=60), data were collected on intraoperative pupil size and postoperative visual acuity (VA), as well as the rate of mechanical pupil dilation, intraoperative floppy iris syndrome (IFIS) and complications. Read More

    Paediatric optic neuritis: factors leading to unfavourable outcome and relapses.
    Br J Ophthalmol 2017 Sep 13. Epub 2017 Sep 13.
    Department of Pediatric Neurology, Hôpitaldes Enfants, CHU Purpan, Toulouse, France.
    Objectives: To identify prognostic factors associated with poor visual recovery and chronic relapsing diseases, for example, multiple sclerosis (MS), in children with optic neuritis (ON) at onset.

    Methods: This multicentre retrospective study included 102 children with a first ON episode between 1990 and 2012. The primary criterion was poor visual recovery determined by visual acuity, and the secondary was relapses following ON. Read More

    Effectiveness of expanding annual mass azithromycin distribution treatment coverage for trachoma in Niger: a cluster randomised trial.
    Br J Ophthalmol 2017 Sep 11. Epub 2017 Sep 11.
    F.I. Proctor Foundation, University of California San Francisco, San Francisco, California, USA.
    Background/aims: The WHO recommends 3-5 years of annual mass azithromycin distribution with at least 80% treatment coverage to districts with active trachoma prevalence over 10% among children. Here, we assess the efficacy of expanding the coverage target to at least 90% for trachoma control in a mesoendemic region of Niger.

    Methods: Twenty-four communities were randomised to a single day of azithromycin distribution with a coverage target of 80% of the community or up to 4 days of treatment, aiming for greater than 90% coverage. Read More

    Characteristics of early filtering blebs that predict successful trabeculectomy identified via three-dimensional anterior segment optical coherence tomography.
    Br J Ophthalmol 2017 Sep 11. Epub 2017 Sep 11.
    Department of Ophthalmology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science, Okayama, Japan.
    Background/aims: To identify the cross-sectional characteristics of filtering blebs at 2 weeks post-trabeculectomy associated with intraocular pressure (IOP) control at 1 year post-trabeculectomy.

    Methods: Ninety-nine eyes of 94 patients who had undergone primary trabeculectomy were included in this retrospective consecutive case series study. Surgical success was defined as an IOP ≤15 mm Hg and a >20% reduction in IOP without glaucoma medication or additional glaucoma surgeries at 1 year post-trabeculectomy. Read More

    Lens power in Iranian schoolchildren: a population-based study.
    Br J Ophthalmol 2017 Aug 31. Epub 2017 Aug 31.
    Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
    Aims: To evaluate lens power (LP) in schoolchildren aged 6-12 years.

    Methods: This cross-sectional study was conducted in Shahroud, northeast Iran. The students were selected through random cluster sampling and underwent the measurements of biometry, uncorrected and corrected visual acuity, non-cycloplegic and cycloplegic refraction. Read More

    Diagnostic accuracy of optical coherence tomography for diagnosing glaucoma: secondary analyses of the GATE study.
    Br J Ophthalmol 2017 Aug 30. Epub 2017 Aug 30.
    Centre for Public Health, Queen's University Belfast, Belfast, UK.
    Background/aims: To assess the diagnostic performance of retinal nerve fibre layer (RNFL) data of optical coherence tomography (OCT) for detecting glaucoma.

    Methods: Secondary analyses of a prospective, multicentre diagnostic study (Glaucoma Automated Tests Evaluation (GATE)) referred to hospital eye services in the UK were conducted. We included data from 899 of 966 participants referred to hospital eye services with suspected glaucoma or ocular hypertension. Read More

    Optical coherence tomography angiography reproducibility of lesion size measurements in neovascular age-related macular degeneration (AMD).
    Br J Ophthalmol 2017 Aug 30. Epub 2017 Aug 30.
    Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil, Université Paris Est Créteil, Creteil, France.
    Purpose: To evaluate the reproducibility and interuser agreement of measurements of choroidal neovascularisation in optical coherence tomography angiography (OCTA).

    Design: Prospective non-interventional study.

    Methods: Consecutive patients, presenting with neovascular age-related macular degeneration (AMD), underwent two sequential OCTA examinations (AngioVue, Optovue, Fremont, California, USA), performed by the same trained examiner. Read More

    A worldwide survey of retinopathy of prematurity screening.
    Br J Ophthalmol 2017 Aug 30. Epub 2017 Aug 30.
    International Pediatric Ophthalmology and Strabismus Council, San Francisco, USA.
    Background: To ascertain which countries in the world have retinopathy of prematurity (ROP) screening programmes and guidelines and how these were developed.

    Methods: An email database was created and requests were sent to ophthalmologists in 141 nations to complete an online survey on ROP screening in their country.

    Results: Representatives from 92/141 (65%) countries responded. Read More

    Prevalence and risk factors for diabetic retinopathy in China: a multi-hospital-based cross-sectional study.
    Br J Ophthalmol 2017 Aug 30. Epub 2017 Aug 30.
    Department of Ophthalmology, The Joint Shantou International Eye Center (JSIEC) of Shantou University and The Chinese University of Hong Kong, Shantou, Guangdong, China.
    Purpose: To determine the prevalence and risk factors for diabetic retinopathy (DR) and sight-threatening diabetic retinopathy (STDR) in a multi-hospital-based DR screening programme among patients with diabetes in China, the Lifeline Express Diabetic Retinopathy Screening Program.

    Methods: Patients with diabetes in eight hospitals across mainland China (both southern and northern) from January 2014 to July 2016 were recruited in this programme. All participants underwent a standardised interview and examinations and received digital fundus photography. Read More

    Keratopigmentation with micronised mineral pigments: complications and outcomes in a series of 234 eyes.
    Br J Ophthalmol 2017 Aug 30. Epub 2017 Aug 30.
    Department of Cornea and Refractive Surgery, VISSUM Corporation, Alicante, Spain.
    Aim: To report the complications observed in a consecutive large series of cases treated with keratopigmentation (KTP).

    Methods: KTP was performed in 234 eyes of 204 patients for therapeutic and cosmetic reasons. From them, 50 eyes of 29 patients suffered complications. Read More

    Risk of corneal ulcer in patients with end-stage renal disease: a retrospective large-scale cohort study.
    Br J Ophthalmol 2017 Aug 30. Epub 2017 Aug 30.
    Graduate Institute of Medical Science, College of Health Science, Chang Jung Christian University, Tainan, Taiwan.
    Background/aims: To investigate the risk of corneal ulcer in patients with end-stage renal disease (ESRD).

    Methods: This retrospective, nationwide, matched cohort study included 92 967 patients with ESRD recruited between 2000 and 2009 from the Taiwan National Health Insurance Research Database. The same number of age-matched and sex-matched patients without ESRD were selected from the Taiwan Longitudinal Health Insurance Database, 2000 as the control group. Read More

    Bullous X linked retinoschisis: clinical features and prognosis.
    Br J Ophthalmol 2017 Aug 28. Epub 2017 Aug 28.
    Medical Retina and Genetics Services, Moorfields Eye Hospital, London, UK.
    Background/aims: A subset of patients with X linked retinoschisis (XLRS) have bullous schisis cavities in the peripheral retina. This study describes the characteristics and prognosis of the bullous form of XLRS.

    Methods: A retrospective case series was performed of nine patients with molecularly proven bullous XLRS seen at a single tertiary centre. Read More

    Prevalence of amblyopia and its association with refraction in Chinese preschool children aged 36-48 months.
    Br J Ophthalmol 2017 Aug 28. Epub 2017 Aug 28.
    Department of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
    Purpose: To determine the prevalence of amblyopia and its association with refraction in Chinese preschool children.

    Methods: The Yuhuatai Pediatric Eye Disease Study, a cross-sectional, population-based study, was conducted in children aged 36-48 months in Yuhuatai District, Nanjing, China, in 2015. Visual acuity was measured in 1695 eligible children. Read More

    Prevalence of age-related macular degeneration in rural southern China: the Yangxi Eye Study.
    Br J Ophthalmol 2017 Aug 28. Epub 2017 Aug 28.
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.
    Purpose: To describe the prevalence of age-related macular degeneration (AMD) among older adults in rural southern mainland China.

    Methods: Eligible persons aged 50 years or over were identified by geographically defined cluster sampling from Yangxi County, Guangdong Province, China. Participants underwent a standardised interview and comprehensive eye examinations from August to November in 2014. Read More

    Risk factors, demographics and clinical profile of Acanthamoeba keratitis in Melbourne: an 18-year retrospective study.
    Br J Ophthalmol 2017 Aug 27. Epub 2017 Aug 27.
    Corneal Unit, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.
    Purpose: To assess incidence, risk factors, presentation and final visual outcome of patients with Acanthamoebakeratitis (AK) treated at the Royal Victorian Eye and Ear Hospital (RVEEH), Melbourne, Australia, over an 18-year period.

    Methods: A retrospective review of all cases of AK managed at RVEEH between January 1998 and May 2016 was performed. Data collected included age, gender, affected eye, signs and symptoms, time between symptoms and diagnosis, risk factors, presenting and final visual acuity (VA), investigations, medical treatment, surgical interventions and length of follow-up. Read More

    Non-invasive method of monitoring retinal vasculitis in patients with birdshot chorioretinopathy using optical coherence tomography.
    Br J Ophthalmol 2017 Aug 26. Epub 2017 Aug 26.
    National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.
    Background/aims: To investigate the utility of using montaged optical coherence tomography (OCT) thickness maps to monitor perivascular thickness as a marker of vasculitic activity in patients with large-vessel retinal vasculitis.

    Methods: This is a retrospective cohort study of 22 eyes of 11 patients with a history of retinal vasculitis associated with birdshot chorioretinopathy (BCR). Patients had serial spectral domain 6×6 mm cube OCT scans centred on the fovea, optic nerve and proximal branches of the superior and inferior retinal vessels. Read More

    Multicentred international review of orbital exenteration and reconstruction in oculoplastic and orbit practice.
    Br J Ophthalmol 2017 Aug 26. Epub 2017 Aug 26.
    Department of Ophthalmology, Tulane University School of Medicine, New Orleans, Louisiana, USA.
    Background: Orbital exenteration is a disfiguring procedure reserved for life-threatening malignancies. This study examines the clinical course and outcomes of a large series of patients who underwent orbital exenteration for malignant periocular neoplasms.

    Methods: This is a retrospective review of patients who underwent orbital exenteration from 1 July 2005 to 30 June 2015 at four tertiary referral centres in the USA, Australia and Canada. Read More

    Active surveillance of choroidal neovascularisation in children: incidence, aetiology and management findings from a national study in the UK.
    Br J Ophthalmol 2017 Aug 26. Epub 2017 Aug 26.
    Department of Paediatric Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, London, UK.
    Background/aims: To determine the UK incidence, demographics, aetiology, management and visual outcome for children developing choroidal neovascularisation (CNV).

    Methods: A prospective population-based observational study of routine practice via the British Ophthalmological Surveillance Unit between January 2012 and December 2013 with subsequent 1-year follow-up in children under 16 years old with newly diagnosed CNV.

    Results: Twenty-seven children with CNV were reported. Read More

    Intravitreal topotecan in the management of refractory and recurrent vitreous seeds in retinoblastoma.
    Br J Ophthalmol 2017 Aug 26. Epub 2017 Aug 26.
    Department of Ocular Oncology Service, National Retinoblastoma Foundation, Centre for Sight, Hyderabad, India.
    Background/aim: To evaluate the efficacy of intravitreal topotecan for refractory or recurrent vitreous seeds in retinoblastoma.

    Methods: Intravitreal injection of topotecan hydrochloride (30 µg/0.15 mL) was provided every 3 weeks by the safety enhanced technique. Read More

    Pterygia are indicators of an increased risk of developing cutaneous melanomas.
    Br J Ophthalmol 2017 Aug 26. Epub 2017 Aug 26.
    Lions Eye Institute, Centre for Ophthalmology and Vision Science, University of Western Australia, Nedlands, Australia.
    Aim: To investigate whether pterygium is an indicator of an increased risk of cutaneous melanoma (CM).

    Methods: A matched-cohort study, using linked health administrative data sets to identify all hospital-treated pterygium in Western Australia (WA) between 1979 and 2014. We identified pterygium cases from hospital diagnosis and/or procedure International Classification of Diseases 9th revision (ICD-9) and 10th revision (ICD-10) codes and matched cases by age, sex and residential postcode to WA Electoral Roll controls with no known history of pterygium. Read More

    Traumatic brain injury, dry eye and comorbid pain diagnoses in US veterans.
    Br J Ophthalmol 2017 Aug 26. Epub 2017 Aug 26.
    Department of Ophthalmology, Miami VA Medical Center, Miami, Florida, USA.
    Aims: The purpose of the study is to evaluate the relationship between dry eye (DE) and pain diagnoses in US veterans with and without traumatic brain injury (TBI).

    Methods: Retrospective cohort study of veterans who were seen in the Veterans Administration Hospital (VA) between 1 January 2010 and 31 December 2014. Veterans were separated into two groups by the presence or absence of an International Classification of Diseases, Ninth Revision diagnosis of TBI and assessed for DE and other comorbidities. Read More

    Cumulative retention rate of adalimumab in patients with Behçet's disease-related uveitis: a four-year follow-up study.
    Br J Ophthalmol 2017 Aug 26. Epub 2017 Aug 26.
    Department of Medical Sciences, Surgery and Neurosciences, Research Center of Systemic Auto inflammatory Diseases and Behçet's Disease and Rheumatology-Ophthalmology Collaborative Uveitis Center, University of Siena, Siena, Italy.
    Background/aims: Adalimumab (ADA) has been shown to be an effective treatment for Behçet's disease (BD)-related uveitis. We aimed at evaluating the cumulative retention rate of ADA during a 48-month follow-up period in patients with BD-related uveitis, the impact of a concomitant use of disease modifying anti-rheumatic drugs (DMARDs) on ADA retention rate, and differences according to the various lines of biologic therapy (ie, first- vs second-line or more). Predictive factors of response to ADA were also investigated. Read More

    Paracrine effects of mesenchymal stem cells on the activation of keratocytes.
    Br J Ophthalmol 2017 Aug 26. Epub 2017 Aug 26.
    Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.
    Aims: The purpose of this study is to investigate the impact of mesenchymal stem cell (MSC)-derived soluble factors on the function of keratocytes, with a particular focus on the processes involved in wound healing, including keratocyte activation, migration and proliferation as well as extracellular matrix (ECM) synthesis.

    Methods: Primary cultured rabbit keratocytes were treated with MSC-conditioned medium (MSC-CM). The paracrine factors released by bone marrow MSCs were examined by ELISA. Read More

    Compressed 3D and 2D digital images versus standard 3D slide film for the evaluation of glaucomatous optic nerve features.
    Br J Ophthalmol 2017 Aug 23. Epub 2017 Aug 23.
    Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Alberta, Canada.
    Synopsis: Clinicians can feel confident compressed three-dimensional digital (3DD) and two-dimensional digital (2DD) imaging evaluating important features of glaucomatous disc damage is comparable to the previous gold standard of stereoscopic slide film photography, supporting the use of digital imaging for teleglaucoma applications.

    Background/aims: To compare the sensitivity and specificity of 3DD and 2DD photography with stereo slide film in detecting glaucomatous optic nerve head features.

    Methods: This prospective, multireader validation study imaged and compressed glaucomatous, suspicious or normal optic nerves using a ratio of 16:1 into 3DD and 2DD (1024×1280 pixels) and compared both to stereo slide film. Read More

    Cost-effectiveness of age-related macular degeneration study supplements in the UK: combined trial and real-world outcomes data.
    Br J Ophthalmol 2017 Aug 23. Epub 2017 Aug 23.
    Institute of Ophthalmology, University College London, London, UK.
    Aims: To evaluate the cost-effectiveness of Age-Related Eye Disease Study (AREDS) 1 & 2 supplements in patients with either bilateral intermediate age-related macular degeneration, AREDS category 3, or unilateral neovascular age-related macular degeneration AMD (nAMD), AREDS category 4.

    Methods: A patient-level health state transition model based on levels of visual acuity in the better-seeing eye was constructed to simulate the costs and consequences of patients taking AREDS vitamin supplements.

    Setting: UK National Health Service (NHS). Read More

    Evaluation of coronary artery disease as a risk factor for reticular pseudodrusen.
    Br J Ophthalmol 2017 Aug 19. Epub 2017 Aug 19.
    Centre for Public Health, Queen's University Belfast, Belfast, UK.
    Purpose: Reticular pseudodrusen (RPD) are a risk factor for late age-related macular degeneration (AMD). Associations between RPD and coronary artery disease (CAD) have been reported from small case-control studies. This study investigated the association of RPD within a predominantly CAD cohort. Read More

    Developing standards for the development of glaucoma virtual clinics using a modified Delphi approach.
    Br J Ophthalmol 2017 Aug 18. Epub 2017 Aug 18.
    NIHR Biomedical Research Centre (BRC) at Moorfields Eye Hospital and UCL Institute of Ophthalmology, London, UK.
    Purpose: To obtain consensus opinion for the development of a standards framework for the development and implementation of virtual clinics for glaucoma monitoring in the UK using a modified Delphi methodology.

    Methods: A modified Delphi technique was used that involved sampling members of the UK Glaucoma and Eire Society (UKEGS). The first round scored the strength of agreement to a series of standards statements using a 9-point Likert scale. Read More

    Epidemiology of discordance between symptoms and signs of dry eye.
    Br J Ophthalmol 2017 Aug 18. Epub 2017 Aug 18.
    Miami Veterans Administration Medical Center, Miami, Florida, USA.
    Background/aims: The frequent lack of association between dry eye (DE) symptoms and signs leads to challenges in diagnosing and assessing the disease.

    Methods: Participants underwent ocular surface examinations to evaluate signs of disease and completed questionnaires to assess ocular symptoms, psychological status and medication use. To assess nociceptive system integrity, quantitative sensory testing (QST), including vibratory and thermal threshold measures and temporal summation of pain were obtained at the forearm and forehead. Read More

    Comparing glaucomatous disc change using stereo disc viewing and the MatchedFlicker programme in glaucoma experts and trainees.
    Br J Ophthalmol 2017 Aug 16. Epub 2017 Aug 16.
    Department of Ophthalmology, University of Florida, Gainesville, Florida, USA.
    Background/aims: The objective of this study is to evaluate the accuracy and speed of trainees and experienced glaucoma specialists using the MatchedFlicker software against the manual examination of stereoscopic disc photographs for detecting glaucomatous optic disc change.

    Methods: Three experienced glaucoma specialists, two resident ophthalmologists and one glaucoma fellow from multiple institutions independently evaluated the same 140 image pairs from 100 glaucomatous/ocular hypertensive eyes using a handheld stereo viewer and the MatchedFlicker programme. Fifty had progression to glaucoma as determined by the Ocular Hypertension Treatment Study (OHTS) Optic Disc Reading Group and endpoint committee, and 50 more were negative controls for progression with photos taken a few minutes apart. Read More

    Intravitreal bevacizumab monotherapy in myopic choroidal neovascularisation: 5-year outcomes for the PAN-American Collaborative Retina Study Group.
    Br J Ophthalmol 2017 Aug 16. Epub 2017 Aug 16.
    Retina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    Purpose: To report the long-term anatomical and visual outcomes of intravitreal bevacizumab (IVB) monotherapy in naive choroidal neovascularisation (CNV) caused by myopia.

    Methods: Retrospective analysis of naive CNV secondary to myopia that underwent antivascular endothelial growth factor monotherapy was performed. Collected data included demographic details, clinical examination details including visual acuity at presentation and follow-up with imaging and treatment details. Read More

    The volume of peripapillary vessels within the retinal nerve fibre layer: an optical coherence tomography angiography study of normal subjects.
    Br J Ophthalmol 2017 Aug 16. Epub 2017 Aug 16.
    Eye Clinic, San Paolo Hospital, University of Milan, Milan, Italy.
    Background/aims: To investigate the contribution of vascular volume calculated by optical coherence tomography angiography (OCTA) to the measurement of peripapillary retinal nerve fibre layer (RNFL) thickness.

    Methods: We used OCTA scans to build volumetric maps of the RNFL angiograms by thresholding the decorrelation images and summing the number of white pixels along the z-axis at each location. We used these maps to calculate the contribution of the vascular tissue to the RNFL thickness. Read More

    Optical coherence tomography angiography enhances the detection of optic nerve damage in multiple sclerosis.
    Br J Ophthalmol 2017 Aug 16. Epub 2017 Aug 16.
    Casey Eye Institute, Oregon Health & Science University, Portland, Oregon, USA.
    Background: Quantitative assessment of optic nerve damage is important in the evaluation of optic neuritis (ON) and multiple sclerosis (MS).

    Objective: To detect optic nerve damage using optical coherence tomography (OCT) and OCT angiography in MS.

    Methods: Peripapillary retinal nerve fibre layer (NFL) thickness, macular ganglion cell complex (GCC) thickness and Optic Nerve Head Flow Index (ONH-FI) were measured. Read More

    Amblyopia and strabismus: trends in prevalence and risk factors among young adults in Israel.
    Br J Ophthalmol 2017 Aug 16. Epub 2017 Aug 16.
    Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel.
    Aims: To estimate the prevalence of amblyopia, present strabismus and amblyopia risk factors (ARFs) among young adults in Israel and to analyse trends over time of prevalence rates.

    Methods: We conducted a cross-sectional study including 107 608 pre-enlistees aged 17.4±0. Read More

    Long-term outcomes with as-needed aflibercept in diabetic macular oedema: 2-year outcomes of the ENDURANCE extension study.
    Br J Ophthalmol 2017 Aug 16. Epub 2017 Aug 16.
    Retina-Vitreous Associates Medical Group, Los Angeles, California, USA.
    Background/aims: To evaluate the efficacy and safety of individualised 2.0 mg intravitreal aflibercept retreatment for diabetic macular oedema (DME) through the fifth year of management.

    Methods: This is a phase IV, 2-year, open-label extension study. Read More

    Local synthesis of sex hormones: are there consequences for the ocular surface and dry eye?
    Br J Ophthalmol 2017 Aug 16. Epub 2017 Aug 16.
    School of Optometry and Vision Science, UNSW, Sydney, Australia.
    Sex hormones are associated with the physiology and pathophysiology of almost all organs in the body, as well as most diseases. Interest in the associations between sex hormones and ocular tissues has increased in recent years. Androgens may have a positive effect on dry eye, whereas the effects of oestrogen on ocular conditions remain unclear. Read More

    Characteristics of primary extranodal marginal zone B-cell lymphoma in Korea: conjunctiva versus other ocular adnexa.
    Br J Ophthalmol 2017 Aug 16. Epub 2017 Aug 16.
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
    Aims: To compare the clinical characteristics and prognosis of primary conjunctival versus other ocular adnexal extranodal marginal zone B-cell lymphoma (EMZL).

    Methods: Retrospective review of clinical records for all consecutive patients with primary ocular adnexal EMZL treated from March 1995 to December 2015.

    Results: 198 patients were evaluated including 81 with primary conjunctival and 117 with other ocular adnexal EMZL. Read More

    Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography.
    Br J Ophthalmol 2017 Aug 16. Epub 2017 Aug 16.
    Vitreo-Retinal Service, Singapore National Eye Centre, Singapore.
    Purpose: Optical coherence tomography angiography (OCT-A) potentially allows for rapid and non-invasive quantification of retinal capillary plexus density in various disease states. This study aims to identify the key features that influenced the repeatability of OCT-A measurements.

    Methods: We obtained OCT-A images on two separate visits in 44 healthy eyes from 44 subjects, each imaged with using the Topcon DRI OCT Triton imaging system. Read More

    Swept-source OCT angiography imaging of the macular capillary network in glaucoma.
    Br J Ophthalmol 2017 Aug 9. Epub 2017 Aug 9.
    Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, USA.
    Purpose: To evaluate the macular capillary network density of superficial and deep retinal layers (SRL/DRL) by swept-source optical coherence tomography angiography (OCTA) in patients with primary open angle glaucoma (POAG) and to compare the results with those of normal subjects.

    Method: In this prospective study, 24 eyes of 24 normal individuals and 24 eyes of 24 patients with mild to moderate POAG underwent fovea centred 6×6 mm cube macular OCTA imaging by a swept-source OCTA device (Triton, Topcon, Tokyo, Japan). Quantitative analysis of the retinal vasculature was performed by assessing vessel density (VD) as the ratio of the retinal area occupied by vessels at the SRL and DRL. Read More

    Non-surgical treatment for eyelid retraction in thyroid eye disease (TED).
    Br J Ophthalmol 2017 Aug 9. Epub 2017 Aug 9.
    Scheie Eye Institute, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
    Thyroid eye disease (TED) is an autoimmune condition with an unpredictable course that may lead to permanent facial disfigurement. Eyelid retraction is one of the most common findings, and frequently demands attention due to ocular exposure and impaired cosmesis. Surgical treatment remains the most effective option, but there is a role for temporary corrections during the active phase of the disease, as well as in patients who are poor surgical candidates. Read More

    1 OF 396