Search our Database of Scientific Publications and Authors

I’m looking for a

    19864 results match your criteria British Journal of Ophthalmology[Journal]

    1 OF 398

    Review of extraocular muscle biopsies and utility of biopsy in extraocular muscle enlargement.
    Br J Ophthalmol 2018 Jan 19. Epub 2018 Jan 19.
    Orbital Plastic and Lacrimal Unit, Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia.
    Aims: To review the distribution of pathology in extraocular muscle (EOM) biopsies performed at a tertiary orbital centre, identify clinical and imaging features which are associated with benign or malignant diseases and indicate when biopsy is necessary for EOM enlargement.

    Methods: Retrospective case series including 93 patients with EOM enlargement who underwent an EOM biopsy. Clinical, radiological and histopathological information was recorded from the medical records. Read More

    Comparison of immunoblotting (IgA and IgG) and the Goldmann-Witmer coefficient for diagnosis of ocular toxoplasmosis in immunocompetent patients.
    Br J Ophthalmol 2018 Jan 17. Epub 2018 Jan 17.
    Department of Ophthalmology, Croix-Rousse University Hospital, Hospices Civils de Lyon, University of Medicine Lyon 1, Lyon, France.
    Background: Ocular toxoplasmosis (OT) is a common cause of posterior uveitis worldwide. The diagnosis of OT is based on clinical findings, but in most cases, laboratory tests are required to confirm the aetiology, especially when other diseases are suspected. The aim of this study was to evaluate which methods, between the Goldmann-Witmer coefficient (GWC) and immunoblotting (IB) with both IgG and IgA, in aqueous humour (AH) samples, can be the most sensitive to diagnose OT, in current practice, especially in the first three weeks. Read More

    Peripapillary vascular changes in radiation optic neuropathy: an optical coherence tomography angiography grading.
    Br J Ophthalmol 2018 Jan 17. Epub 2018 Jan 17.
    Department of Ophthalmology, University of Padova, Padova, Italy.
    Aims: To investigate peripapillary vascular changes secondary to radiation optic neuropathy (RON) using optical coherence tomography angiography (OCT-A) and to propose a clinical grading of RON based on OCT-A findings.

    Methods: Thirty-four patients affected by RON were consecutively included. Each patient underwent best corrected visual acuity measurement (ETDRS score) and OCT-A (Nidek RS-3000 Advance device, Nidek, Gamagori, Japan). Read More

    Quarter-Descemet membrane endothelial keratoplasty (Quarter-DMEK) for Fuchs endothelial corneal dystrophy: 6 months clinical outcome.
    Br J Ophthalmol 2018 Jan 17. Epub 2018 Jan 17.
    Netherlands Institute for Innovative Ocular Surgery, Rotterdam, The Netherlands.
    Background/aim: To assess the clinical outcome of the first series of Quarter-Descemet membrane endothelial keratoplasty (Quarter-DMEK), a potential hybrid technique between 'descemetorhexis only' and conventional, circular DMEK.

    Methods: Prospective interventional case series at a tertiary referral centre. Twelve eyes of 12 patients with central Fuchs endothelial corneal dystrophy underwent Quarter-DMEK, that is, transplantation of one quadrant of a full-diameter DMEK graft, and were evaluated for best-corrected visual acuity (BCVA), endothelial cell density (ECD) and complications up to 6 months postoperatively. Read More

    Effect of intravitreal triamcinolone acetonide injection at the end of vitrectomy for vitreous haemorrhage related to proliferative diabetic retinopathy.
    Br J Ophthalmol 2018 Jan 17. Epub 2018 Jan 17.
    Department of Ophthalmology, Faculty of Medical Sciences, University of Fukui, Yoshida, Fukui, Japan.
    Background/aims: To investigate whether intravitreal injection of triamcinolone acetonide (IVTA) combined with vitrectomy prevents postoperative inflammation in patients with vitreous haemorrhage (VH) due to proliferative diabetic retinopathy (PDR).

    Methods: This prospective, multicentre, randomised study conducted at seven sites in Japan enrolled patients diagnosed as having VH following PDR. Patients underwent vitrectomy with (IVTA+VIT group) or without (VIT group) IVTA at the end of the surgery. Read More

    Visual outcomes after chemotherapy for optic pathway glioma in children with and without neurofibromatosis type 1: results of the International Society of Paediatric Oncology (SIOP) Low-Grade Glioma 2004 trial UK cohort.
    Br J Ophthalmol 2018 Jan 17. Epub 2018 Jan 17.
    Leeds Teaching Hospitals NHS Trust, Leeds, UK.
    Aims: To report visual acuity (VA) outcomes following chemotherapy for optic pathway glioma (OPG) in children with or without neurofibromatosis type-1 (NF1) and to analyse associated risk factors.

    Methods: A prospective, multicentre, cohort study involving 155 children treated between September 2004 and December 2012. Initial and final VA was used for per-eye and per-subject analysis. Read More

    Inter-relationship between ocular perfusion pressure, blood pressure, intraocular pressure profiles and primary open-angle glaucoma: the Singapore Epidemiology of Eye Diseases study.
    Br J Ophthalmol 2018 Jan 13. Epub 2018 Jan 13.
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
    Objective: To elucidate the inter-relationship between ocular perfusion pressure (OPP), blood pressure (BP), intraocular pressure (IOP) profiles and primary open-angle glaucoma (POAG) in a multiethnic Asian population.

    Methods: Participants were recruited from the Singapore Epidemiology of Eye Diseases Study and underwent standardised ocular and systemic examinations. POAG was defined according to the International Society for Geographical and Epidemiological Ophthalmology criteria. Read More

    SITA-Standard perimetry has better performance than FDT2 matrix perimetry for detecting glaucomatous progression.
    Br J Ophthalmol 2018 Jan 13. Epub 2018 Jan 13.
    Department of Biostatistics, University of Iowa, College of Medicine Veterans Administration Healthcare System, Iowa City, Iowa, USA.
    Purpose: The Humphrey Matrix (FDT2) may be more sensitive in detecting glaucomatous visual field loss than SITA standard automated perimetry (SAP) performed on the Humphrey Field Analyzer (HFA). Therefore, FDT may be a good candidate to determine disease progression in patients with glaucoma. Our aim was to test the hypothesis that automated perimetry using the FDT2 would be equal to, or more effective than, HFA SITA-Standard, in identifying glaucomatous progression. Read More

    Comparative analysis of the safety and efficacy of intracameral cefuroxime, moxifloxacin and vancomycin at the end of cataract surgery: a meta-analysis.
    Br J Ophthalmol 2018 Jan 11. Epub 2018 Jan 11.
    Department of Ophthalmology, University of Utah, Salt Lake City, Utah, USA.
    Background: Current practice methods are unclear as to the most safe and effective prophylactic pharmacotherapy and method of delivery to reduce postoperative endophthalmitis occurrence.

    Methods: A systematic review and meta-analysis using Meta-analysis of Observational Studies in Epidemiology guidelines was performed to compare the efficacy of intracameral cefuroxime, moxifloxacin and vancomycin in preventing postphacoemulsification cataract surgery endophthalmitis. A safety analysis of intracameral antibiotics was concurrently performed. Read More

    Two-year outcomes of intravitreal ziv-aflibercept.
    Br J Ophthalmol 2018 Jan 9. Epub 2018 Jan 9.
    Smt. Kanuri Santhamma Centre for Vitreoretinal Diseases, LV Prasad Eye Institute, Hyderabad, Andhra Pradesh, India.
    Aim: To assess the two-year outcome of intravitreal ziv-aflibercept (IVZ) in eyes with macular diseases.

    Methods: Consecutive subjects with various macular diseases that received six or more of 0.05 mL IVZ (1. Read More

    Mechanical stress potentiates the differentiation of periodontal ligament stem cells into keratocytes.
    Br J Ophthalmol 2018 Jan 6. Epub 2018 Jan 6.
    Department of Integrative Medical Biology, Umeå University, Umeå, Sweden.
    Aims: To explore the role of corneal-shaped static mechanical strain on the differentiation of human periodontal ligament stem cells (PDLSCs) into keratocytes and the possible synergistic effects of mechanics and inducing medium.

    Methods: PDLSCs were exposed to 3% static dome-shaped mechanical strain in a Flexcell Tension System for 3 days and 7 days. Keratocyte phenotype was determined by gene expression of keratocyte markers. Read More

    Binocular stereo acuity affects monocular three-dimensional shape perception in patients with strabismus.
    Br J Ophthalmol 2018 Jan 6. Epub 2018 Jan 6.
    Department of Neuroscience, University of Parma, Parma, Italy.
    Background/aims: To evaluate the perception of three-dimensional (3D) shape in patients with strabismus and the contributions of stereopsis and monocular cues to this perception.

    Methods: Twenty-one patients with strabismus with and 20 without stereo acuity as well as 25 age-matched normal volunteers performed two tasks: (1) identifying the closest vertices of 3D shapes from monocular shading (3D-SfS), texture (3D-SfT) or motion cues (3D-SfM) and from binocular disparity (3D-SfD), (2) discriminating 1D elementary features of these cues.

    Results: Discrimination of the elementary features of luminance, texture and motion did not differ across groups. Read More

    Characteristic optical coherence tomography findings in patients with primary vitreoretinal lymphoma: a novel aid to early diagnosis.
    Br J Ophthalmol 2018 Jan 6. Epub 2018 Jan 6.
    NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK.
    Background: The diagnosis of primary vitreoretinal lymphoma (PVRL) poses significant difficulties; presenting features are non-specific and confirmation usually necessitates invasive vitreoretinal biopsy. Diagnosis is often delayed, resulting in increased morbidity and mortality. Non-invasive imaging modalities such as spectral domain optical coherence tomography (SD-OCT) offer simple and rapid aids to diagnosis. Read More

    Implementation of medical retina virtual clinics in a tertiary eye care referral centre.
    Br J Ophthalmol 2018 Jan 6. Epub 2018 Jan 6.
    Medical Retina Department, Moorfields Eye Hospital NHS Foundation Trust, London, UK.
    Background: The increasing incidence of medical retinal diseases has created capacity issues across UK. In this study, we describe the implementation and outcomes of virtual medical retina clinics (VMRCs) at Moorfields Eye Hospital, South Division, London. It represents a promising solution to ensure that patients are seen and treated in a timely fashion METHODS: First attendances in the VMRC (September 2016-May 2017) were included. Read More

    Risk factors for incidence of trachomatous scarring in a cohort of women in low endemic district.
    Br J Ophthalmol 2018 Jan 6. Epub 2018 Jan 6.
    Dana Center for Preventative Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
    Background/aims: To determine the incidence of scarring in women in a trachoma low endemic district of rural Tanzania and to determine the effects of lifetime cooking fire exposure and markers of lower socioeconomic status on incidence of scarring in these women.

    Methods: A prospective cohort study was conducted over a 3.5-year period from 2013 to 2016 in 48 villages in Kongwa, Tanzania where trachoma at baseline was 5. Read More

    Corneal endothelial alterations in alcohol dependence syndrome.
    Br J Ophthalmol 2018 Jan 5. Epub 2018 Jan 5.
    Center for Excellence in Cornea and Ocular Surface Disorders, Excel Eye Care, Ahmedabad, India.
    Background/aims: To evaluate the corneal endothelial changes in patients with alcohol dependence syndrome (ADS).

    Methods: A total of 322 corneas of 322 subjects were studied, and two groups were formed. The first, the ADS group, included 161 corneas of 161 patients and the second, the age-matched control group, was composed of 161 corneas of 161 healthy subjects. Read More

    Topography-guided identification of leakage point in central serous chorioretinopathy: a base for fluorescein angiography-free focal laser photocoagulation.
    Br J Ophthalmol 2018 Jan 4. Epub 2018 Jan 4.
    Smt. Kanuri Santhamma Retina Vitreous Centre, L V Prasad Eye Institute, Hyderabad, Andhra Pradesh, India.
    Purpose: To identify optical coherence tomography (OCT) findings associated with the leakage points in patients with central serous chorioretinopathy (CSC) to provide fluorescein angiography (FA)-free focal laser photocoagulation (FLP) of the leakage point.

    Methods: A retrospective study included 48 patients with CSC (48 eyes). Colocalisation of leakage points with pigment epithelial detachments (PEDs) and with areas of photoreceptor outer segments (PROS) layer thinning was evaluated with OCT. Read More

    Avoiding big bubble complications: outcomes of layer-by-layer deep anterior lamellar keratoplasty in children.
    Br J Ophthalmol 2018 Jan 4. Epub 2018 Jan 4.
    Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
    Background/aims: To describe the visual and clinical outcomes of manual layer-by-layer deep anterior lamellar keratoplasty (DALK) in a paediatric population.

    Methods: The charts of all children who underwent DALK surgery between January 2007 and January 2015 were reviewed retrospectively. Data collected included preoperative and postoperative spectacle-corrected distance visual acuity (CDVA), intraoperative and postoperative complications including graft rejection and failure. Read More

    Population-based assessment of visual acuity outcomes following cataract surgery in Australia: the National Eye Health Survey.
    Br J Ophthalmol 2018 Jan 4. Epub 2018 Jan 4.
    Centre for Eye Research Australia Ltd, Royal Victorian Eye & Ear Hospital, East Melbourne, Victoria, Australia.
    Aim: To assess the visual outcomes of cataract surgery among a national sample of non-Indigenous and Indigenous Australians.

    Methods: This was a population-based study of 3098 non-Indigenous Australians (50-98 years) and 1738 Indigenous Australians (40-92 years), stratified by remoteness. A poor postoperative outcome in an eye that had undergone cataract surgery was defined as presenting distance visual acuity (PVA) <6/12-6/60, and a very poor outcome was defined as PVA <6/60. Read More

    Acanthamoeba keratitis in 194 patients: risk factors for bad outcomes and severe inflammatory complications.
    Br J Ophthalmol 2018 Jan 3. Epub 2018 Jan 3.
    Moorfields Eye Hospital NHS Foundation Trust, London, UK.
    Background/aims: To determine demographic and clinical features of patients with Acanthamoeba keratitis (AK) that are independent risk factors both for bad outcomes and for severe inflammatory complications (SIC).

    Methods: A retrospective audit of medical records of AK cases at Moorfields Eye Hospital from July 2000 to April 2012, including 12 earlier surgical cases. Cases with a bad outcome were defined as those having one or more of the following: corneal perforation, keratoplasty, other surgery (except biopsy), duration of antiamoebic therapy (AAT) ≥10. Read More

    Prevalence of keratoconus in paediatric patients in Riyadh, Saudi Arabia.
    Br J Ophthalmol 2018 Jan 3. Epub 2018 Jan 3.
    Ocular Cell Biology Group, Center for Applied Biotechnology and Molecular Medicine, University of Zurich, Zurich, Switzerland.
    Background/aim: Keratoconus (KC) is a ectatic corneal disorder with marked progression during childhood and puberty that may lead to severe visual loss. In addition to KC prevalence, estimate shows major geographical variations; recent studies using Scheimpflug technology are in contrast to the 1980s and 1990s literature. The present study aims to determine the prevalence of KC in paediatric patients in Riyadh, Saudi Arabia (KSA). Read More

    Results of viscobubble deep anterior lamellar keratoplasty after failure of pneumatic dissection.
    Br J Ophthalmol 2017 Dec 23. Epub 2017 Dec 23.
    IRFO (Istituto internazionale di Ricerca e Formazione in Oftalmologia), Forli, Italy.
    Aim: To report the outcomes of bubble formation obtained by means of intrastromal injection of ophthalmic viscoelastic device (OVD) after failure of pneumatic dissection for deep anterior lamellar keratoplasty (DALK).

    Methods: DALK was performed in 140 keratoconic eyes of 130 patients by injecting air and OVD only secondarily, after pneumatic dissection had failed; the bubble formation rates after air and OVD injection were recorded; complications, best spectacle-corrected visual acuity (BSCVA) and corneal tomographic parameters were evaluated 3 months, 6 months and 12 months postoperatively, as well as after complete suture removal.

    Results: Air injection created a big bubble in 106/140 eyes (75. Read More

    Genetic risk factors for late age-related macular degeneration in India.
    Br J Ophthalmol 2017 Dec 19. Epub 2017 Dec 19.
    Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK.
    Background/aims: There are limited data from India on genetic variants influencing late age-related macular degeneration (AMD). We have previously reported associations from a population-based study in India (the India age-related eye disease study (INDEYE)) of early AMD and single nucleotide polymorphisms (SNPs) in ARMS2/HTRA1 and no association with CFH, C2 or CFB. Late AMD cases were too few for meaningful analyses. Read More

    Optical coherence tomography angiography analysis of foveal microvascular changes and inner retinal layer thinning in patients with diabetes.
    Br J Ophthalmol 2017 Dec 19. Epub 2017 Dec 19.
    Department of Ophthalmology, Kyung Hee University Medical Center, Kyung Hee University, Seoul, South Korea.
    Aim: To evaluate the correlation between inner retinal layer thinning and the foveal microvasculature in type 2 diabetes using optical coherence tomography angiography (OCTA).

    Methods: A cross-sectional study involved 155 diabetic eyes. All patients were divided into two groups based on diabetic retinopathy (DR) grade: no DR (NDR, n=80) and mild-to-moderate non-proliferative DR (NPDR, n=75). Read More

    Lid splinting eyelid retraction technique: a minimised sterile approach for intravitreal injections.
    Br J Ophthalmol 2017 Dec 15. Epub 2017 Dec 15.
    Division of Ophthalmology, University of Calgary, Calgary, Alberta, Canada.
    Background/aims: To describe an alternative technique for avoiding contact with the lids and lashes, without the use of a lid speculum, during intravitreal anti-vascular endothelial growth factor injections.

    Methods: Retrospective case series of all patients undergoing intravitreal injections of bevacizumab and ranibizumab, with the lid splinting retraction technique from January 2010 to December 2015. Injections performed by six vitreoretinal specialists were included. Read More

    Baerveldt shunt surgery versus combined Baerveldt shunt and phacoemulsification: a prospective comparative study.
    Br J Ophthalmol 2017 Dec 15. Epub 2017 Dec 15.
    Department of Ophthalmology, Jules Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland.
    Aim: To examine the efficacy and safety of Baerveldt tube (BT) implantation compared with combined phacoemulsification and Baerveldt tube (PBT) implantation in patients with refractory glaucoma.

    Methods: Seventy-six eyes of 76 patients were enrolled, 38 pseudophakic eyes underwent BT implantation alone and 38 phakic eyes underwent the BT implantation combined with phacoemulsification. Groups were matched for preoperative intraocular pressure (IOP) and number of glaucoma medications. Read More

    Corneal perforation from peripheral ulcerative keratopathy in patients with rheumatoid arthritis: epidemiological findings of the British Ophthalmological Surveillance Unit.
    Br J Ophthalmol 2017 Dec 15. Epub 2017 Dec 15.
    Ophthalmology Department, Princess Alexandra Eye Pavilion, Edinburgh, UK.
    Background/aims: This study quantifies the threat to vision and the survival in patients presenting with peripheral ulcerative keratopathy (PUK) corneal perforation associated with rheumatoid arthritis (RA) in the UK.

    Methods: New cases of corneal perforation from PUK in patients with RA were prospectively collected from the UK via the British Ophthalmological Surveillance Unit from July 2012 to June 2014. An initial questionnaire collected data on presentation and the first 2 weeks' management, and a follow-up questionnaire collected 1-year data on ocular morbidity and mortality. Read More

    Antivascular endothelial growth factor agents pretreatment before vitrectomy for complicated proliferative diabetic retinopathy: a meta-analysis of randomised controlled trials.
    Br J Ophthalmol 2017 Dec 15. Epub 2017 Dec 15.
    Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
    Background/aims: To evaluate the efficacy of antivascular endothelial growth factor (anti-VEGF) agents pretreatment before vitrectomy for patients with complicated proliferative diabetic retinopathy (PDR).

    Methods: The PubMed, Embase and the Cochrane Central Register of Controlled Trials were searched up to June 2017 to identify related studies. The Peferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were followed. Read More

    Nerve terminals at the human corneoscleral limbus.
    Br J Ophthalmol 2017 Dec 15. Epub 2017 Dec 15.
    Larry A Donoso Laboratory for Eye Research, Section of Academic Ophthalmology, Division of Clinical Neuroscience, University of Nottingham, Nottingham, United Kingdom.
    Aims: To demonstrate and characterise distinct subepithelial compact nerve endings (CNE) at the human corneoscleral limbus.

    Methods: Ten fresh human donor corneoscleral discs (mean age, 67 years) and 26 organ-cultured corneoscleral rims (mean age, 59 years) were studied. All samples were subjected to enzyme histochemical staining related to endogenous acetylcholinesterase present in nerve tissue and H&E staining. Read More

    Frequency of a diagnosis of glaucoma in individuals who consume coffee, tea and/or soft drinks.
    Br J Ophthalmol 2017 Dec 14. Epub 2017 Dec 14.
    Department of Ophthalmology, Stein Eye Institute, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
    Aims: To evaluate the association between consumption of coffee, tea or soft drinks, and glaucoma in the participants of the 2005-2006 National Health and Nutrition Examination Survey (NHANES).

    Methods: The exposures of interest of this retrospective cross-sectional study were caffeinated and decaffeinated coffee, iced tea, hot tea and soft drinks. The outcome of interest was a clinical diagnosis of glaucoma based on the Rotterdam criteria. Read More

    Choroidal neovascular membrane in paediatric patients: clinical characteristics and outcomes.
    Br J Ophthalmol 2017 Dec 7. Epub 2017 Dec 7.
    Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA.
    Purpose: To analyse the clinical characteristics and treatment outcomes of choroidal neovascular membranes (CNVM) in paediatric subjects at three paediatric retina referral centres.

    Methods: Medical charts of patients aged 18 years or less with a diagnosis of CNVM were retrospectively reviewed. The demographic profile, laterality, presenting complaint, corrected vision, underlying pathology, fundus, fundus fluorescein angiogram and optical coherence tomogram (OCT) were analysed. Read More

    Novel ocular toxicity associated with fibroblast growth factor receptor (FGFR) inhibitors in cancer treatment: observational case series.
    Br J Ophthalmol 2017 Dec 7. Epub 2017 Dec 7.
    Department of Ophthalmology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
    Aims: To describe novel ocular toxicity in patients with metastatic cancer undergoing chemotherapy with fibroblast growth factor receptor (FGFR) inhibitors.

    Methods: This observational case series study included five patients with advanced cancer who received selected pan-FGFR inhibitors as single chemotherapy in the framework of a dose-finding study and phase I and phase II clinical studies. In all cases, subfoveal neurosensory retinal detachment was diagnosed. Read More

    Trabeculectomy bleb needling and antimetabolite administration practices in the UK: a glaucoma specialist national survey.
    Br J Ophthalmol 2017 Dec 6. Epub 2017 Dec 6.
    Glaucoma Unit, Manchester Royal Eye Hospital, Manchester, UK.
    Aims: To evaluate, describe and quantify the diversity in postoperative antimetabolite administration and bleb needling practices among glaucoma specialists performing trabeculectomy surgery within the UK and Ireland.

    Methods: A cross-sectional online survey was distributed to all consultant glaucoma specialists who are on the United Kingdom and Eire Glaucoma Society (UKEGS) contact list. Participants were asked specific questions about their current practices for post-trabeculectomy antimetabolite administration followed by questions directly related to bleb needling procedures. Read More

    Vision in former very low birthweight young adults with and without retinopathy of prematurity compared with term born controls: the NZ 1986 VLBW follow-up study.
    Br J Ophthalmol 2017 Dec 6. Epub 2017 Dec 6.
    Christchurch Health and Development Study, University of Otago, Christchurch, New Zealand.
    Objective: There are few data on visual outcomes in adulthood of former very low birthweight (VLBW; <1500 g) infants. We aimed to assess vision at 27-29 years in a national cohort of VLBW infants born in 1986 and assessed for retinopathy of prematurity (ROP) when no treatment was available, compared with term born controls.

    Methods: The cohort and controls attended a 2-day assessment in Christchurch as part of a larger study. Read More

    Choriocapillaris flow deficit in Bietti crystalline dystrophy detected using optical coherence tomography angiography.
    Br J Ophthalmol 2017 Dec 2. Epub 2017 Dec 2.
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto City, Japan.
    Background/aims: This study aimed to evaluate blood flow in the choriocapillaris in patients with Bietti crystalline dystrophy (BCD) with CYP4V2 mutations using optical coherence tomography angiography (OCTA), and to explore the parameters associated with visual function.

    Methods: This prospective case-series study included 13 eyes of 13 consecutive patients with BCD with CYP4V2 mutations and 20 healthy eyes. Using OCTA, we obtained en face images of blood flow in the choriocapillaris. Read More

    Wide-field en face swept-source optical coherence tomography angiography using extended field imaging in diabetic retinopathy.
    Br J Ophthalmol 2017 Nov 29. Epub 2017 Nov 29.
    Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, USA.
    Aims: To examine the feasibility of wide-field en face swept-source optical coherence tomography angiography (SS-OCTA) with extended field imaging (EFI) for evaluation of the retinal vasculature in diabetic retinopathy (DR).

    Methods: This study included 37 eyes of 27 patients (age, 65±10 years; male patients, 18; female patients, 9) with DR. All patients underwent comprehensive ophthalmological examination, including OCTA and fluorescein angiography (FA). Read More

    Macular thickness profile and diabetic retinopathy: the Singapore Epidemiology of Eye Diseases Study.
    Br J Ophthalmol 2017 Nov 24. Epub 2017 Nov 24.
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore.
    Background: To evaluate retinal thickness profiles in eyes with and without diabetic retinopathy (DR) using spectral-domain optical coherence tomography (SD-OCT) among individuals with diabetes.

    Methods: Participants were recruited from the Singapore Epidemiology of Eye Diseases Study, a population-based study among Chinese, Malays and Indians aged 40 years or older residing in Singapore. All participants underwent standardised systemic and ophthalmic examinations. Read More

    Time and motion studies of National Health Service cataract theatre lists to determine strategies to improve efficiency.
    Br J Ophthalmol 2017 Nov 24. Epub 2017 Nov 24.
    Department of Ophthalmology, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
    Aim: To provide a quantitative assessment of cataract theatre lists focusing on productivity and staffing levels/tasks using time and motion studies.

    Methods: National Health Service (NHS) cataract theatre lists were prospectively observed in five different institutions (four NHS hospitals and one private hospital). Individual tasks and their timings of every member of staff were recorded. Read More

    Natural history of primary paediatric optic nerve sheath meningioma: case series and review.
    Br J Ophthalmol 2017 Nov 16. Epub 2017 Nov 16.
    Department of Ophthalmology, South Australian Institute of Ophthalmology, Adelaide, South Australia, Australia.
    Purpose: To study the natural history, clinical and radiological characteristics of primary paediatric optic nerve sheath meningioma (PPONSM).

    Methods: Retrospective study of eight paediatric patients who were treated between 1994 and 2016 at the University Hospital Zurich, Switzerland and the Royal Adelaide Hospital, Australia. Clinical records and imaging studies were reviewed. Read More

    Comparison among adjuvant treatments for primary pterygium: a network meta-analysis.
    Br J Ophthalmol 2017 Nov 16. Epub 2017 Nov 16.
    Department of Radiotherapy, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.
    Purpose: Pterygium is a frequent ocular disease, where the major challenge is the high level of recurrence after its surgical removal. We performed a network meta-analysis to identify, among several adjuvant treatments for primary pterygium, which is the best to prevent recurrence.

    Methods: A search was conducted using PubMed, Scientific Electronic Library Online, Latin American and Caribbean Centre on Health Sciences and Cochrane Eyes and Vision Group Trials Register between 1993 and 2015 for randomisedclinical trials (RCTs) comparing adjuvant treatments following primary pterygium surgery. Read More

    Blepharitis as an early sign of metabolic syndrome: a nationwide population-based study.
    Br J Ophthalmol 2017 Nov 16. Epub 2017 Nov 16.
    Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan.
    Background: To investigate the relationship between blepharitis and metabolic syndrome (MetS) by using the Longitudinal Health Insurance Database (LHID) of Taiwan.

    Methods: This retrospective cohort study was conducted using data collected from the LHID for the period from 2009 to 2013. This study enrolled patients who received a diagnosis of blepharitis according to the International Classification of Diseases, Ninth Revision, diagnostic code. Read More

    Visual field indices and patterns of visual field deficits in mesopic and dark-adapted two-colour fundus-controlled perimetry in macular diseases.
    Br J Ophthalmol 2017 Nov 16. Epub 2017 Nov 16.
    Department of Ophthalmology, University of Bonn, Bonn, Germany.
    Background/aims: To analyse the retest reliability of visual field indices and to describe patterns of visual field deficits in mesopic and dark-adapted two-colour fundus-controlled perimetry (FCP) in macular diseases.

    Methods: Seventy-seven eyes (30 eyes with macular diseases and 47 normal eyes) underwent duplicate mesopic and dark-adapted two-colour FCP (Scotopic Macular Integrity Assessment, CenterVue). Non-weighted (mean defect, loss variance), variability-weighted (mean deviation, pattern standard deviation (PSD)) and graphical (cumulative defect (Bebie) curves) indices were computed. Read More

    Non-aesthetic indications for periocular hyaluronic acid filler treatment: a review.
    Br J Ophthalmol 2017 Nov 16. Epub 2017 Nov 16.
    Corneo-plastic Unit, Queen Victoria Hospital NHS Foundation Trust, East Grinstead, United Kingdom.
    Dermal fillers have been in use for many years for aesthetic rejuvenation of the face. More recently, however, fillers have been increasingly used as an alternative to traditional surgical procedures for non-aesthetic indications. These indications include lagophthalmos, eyelid malpositions and orbital volume deficiency. Read More

    Is there consensus in defining childhood cerebral visual impairment? A systematic review of terminology and definitions.
    Br J Ophthalmol 2017 Nov 16. Epub 2017 Nov 16.
    Developmental Neurosciences Programme, UCL GOS Institute of Child Health University College London, London, UK.
    The childhood condition of visual difficulties caused by brain damage, commonly termed cortical or cerebral visual impairment (CVI), is well established but has no internationally accepted definition. Clarification of its core features is required to advance research and clinical practice. This systematic review aimed to identify the definitions of childhood CVI in the original scientific literature to describe and critically appraise a consensual definition of the condition. Read More

    Prevalence and factors associated with age-related macular degeneration in a southwestern island population of Japan: the Kumejima Study.
    Br J Ophthalmol 2017 Nov 16. Epub 2017 Nov 16.
    Kanto Central Hospital of The Mutual Aid Association of Public School Teachers, Tokyo, Japan.
    Aims: To evaluate the prevalence of and factors associated with age-related macular degeneration (AMD) in a rural population of southwestern Japan.

    Methods: This population-based cross-sectional study of all residents aged 40 years or older was conducted on the island of Kumejima, Okinawa, Japan. Of 4632 eligible residents, 3762 completed a comprehensive questionnaire and underwent ocular examination (participant rate, 81. Read More

    Ocular findings in Loeys-Dietz syndrome.
    Br J Ophthalmol 2017 Nov 16. Epub 2017 Nov 16.
    Department of Ophthalmology, Charité-University Medicine Berlin, Berlin, Germany.
    Background: Loeys-Dietz syndrome (LDS), an autosomal-dominant connective tissue disorder, is characterised by systemic manifestations including arterial aneurysm and craniofacial dysmorphologies. Although ocular involvement in LDS has been reported, detailed information on those manifestations is lacking.

    Methods: Retrospective chart review of patients with diagnosed LDS and comparison with age-matched control patients. Read More

    Keratolimbal allograft for limbal stem cell deficiency after severe corneal chemical injury: a systematic review.
    Br J Ophthalmol 2017 Nov 15. Epub 2017 Nov 15.
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.
    Purpose: To review the published literature on outcomes of keratolimbal allograft (KLAL) for the surgical treatment of limbal stem cell deficiency (LSCD) and corneal blindness after severe corneal chemical injury.

    Methods: Literature searches were conducted in the following electronic databases: MEDLINE, EMBASE, Science Citation Index, CINAHL, LILACS and the Cochrane Library. Standard systematic review methodology was applied. Read More

    Adaptive optics imaging of inherited retinal diseases.
    Br J Ophthalmol 2017 Nov 15. Epub 2017 Nov 15.
    UCL Institute of Ophthalmology, University College London, London, UK.
    Adaptive optics (AO) ophthalmoscopy allows for non-invasive retinal phenotyping on a microscopic scale, thereby helping to improve our understanding of retinal diseases. An increasing number of natural history studies and ongoing/planned interventional clinical trials exploit AO ophthalmoscopy both for participant selection, stratification and monitoring treatment safety and efficacy. In this review, we briefly discuss the evolution of AO ophthalmoscopy, recent developments and its application to a broad range of inherited retinal diseases, including Stargardt disease, retinitis pigmentosa and achromatopsia. Read More

    Comparison of preservation and transportation protocols for preloaded Descemet membrane endothelial keratoplasty.
    Br J Ophthalmol 2017 Nov 13. Epub 2017 Nov 13.
    Department of Eye and Vision Science, University of Liverpool Institute of Ageing and Chronic Disease, Liverpool, UK.
    Background/aims: Descemet membrane endothelial keratoplasty (DMEK) preparation is technically demanding and is a limiting factor for uptake of this kind of surgery. Supply methods that simplify the procedure for surgeons are key to increasing uptake. This study compares two different shipping protocols for DMEK. Read More

    Ruthenium-106 brachytherapy for iris and iridociliary melanomas.
    Br J Ophthalmol 2017 Nov 9. Epub 2017 Nov 9.
    Department of Radiation Oncology, Leiden University Medical Center, Leiden, The Netherlands.
    Background And Purpose: To evaluate ruthenium-106 (Ru106) brachytherapy as eye-conserving treatment of iris melanomas (IMs) and iridociliary melanomas (ICMs).

    Materials And Methods: Eighty-eight patients received Ru106 brachytherapy between 2006 and 2016. Primary outcome was local control, and secondary outcomes were metastasis, survival, eye preservation, complications and visual acuity (VA). Read More

    1 OF 398