20,645 results match your criteria British Journal of Ophthalmology[Journal]


Medical treatment in thyroid eye disease in 2020.

Br J Ophthalmol 2020 May 23. Epub 2020 May 23.

Department of Surgery, University of Melbourne, Centre for Eye Research Australia Ltd, East Melbourne, Victoria, Australia.

Thyroid eye disease (TED) affects 25% of patients with Graves' hyperthyroidism, where 1 in 20 patients has active, moderate-to-severe disease that will require medical treatment for reducing TED activity and severity. Intravenous corticosteroid has been the mainstay of treatment for active moderate-to-severe TED. With improved understanding of the pathophysiology of TED, immunotherapy targeting different molecular pathways including T cells, B cells, cytokines and cell surface receptors have been investigated in randomised clinical trials. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-316051DOI Listing

Association of alcohol intake with incidence and progression of diabetic retinopathy.

Br J Ophthalmol 2020 May 23. Epub 2020 May 23.

Ophthalmology, University of Melbourne, Melbourne, Victoria, Australia

Purpose: We examined the longitudinal association of baseline alcohol intake and frequency with the 6-year incidence and progression of diabetic retinopathy (DR) in a population-based cohort of Singaporean Indians.

Methods: We included 656 participants with diabetes mellitus, gradable retinal photographs from baseline (2007-2009) and follow-up (2013-2015) examinations, information on alcohol intake and other relevant data from the Singapore Indian Eye Study were included. Incident DR was defined using the Modified Airlie House Classification as no DR at baseline and at least minimal non-proliferative DR at follow-up; and DR progression as at least a one-step worsening in DR at follow-up from minimal or worse status at baseline, excluding those with proliferative DR. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-316360DOI Listing

Characteristics of myopic traction maculopathy in myopic Singaporean adults.

Br J Ophthalmol 2020 May 23. Epub 2020 May 23.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore

Purpose: To investigate the characteristics, risk factors and visual impact of myopic traction maculopathy (MTM) among adults with myopia in Singapore.

Methods: We analysed 3316 myopic eyes of adults aged over 40 years who participated in the Singapore Epidemiology of Eye Diseases-2 study. Detailed questionnaires and ophthalmic examinations were conducted. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-316182DOI Listing

Determinants of lamina cribrosa depth in healthy Asian eyes: the Singapore Epidemiology Eye Study.

Br J Ophthalmol 2020 May 20. Epub 2020 May 20.

Department of Biomedical Engineering, National University of Singapore, Singapore

Aim: To investigate the determinants of lamina cribrosa depth (LCD) in healthy eyes of Chinese and Indian Singaporean adults.

Methods: The optic nerve head (ONH) of the right eye of 1396 subjects (628 Chinese and 768 Indian subjects) was imaged with optical coherence tomography (OCT, Spectralis, Heidelberg, Germany). LCD was defined as the distance from the Bruch's membrane opening (LCD-BMO) or the peripapillary sclera (LCD-PPS) reference plane to the laminar surface. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-315840DOI Listing

Managing patients with choroidal melanoma in the COVID-19 era: a personal perspective.

Authors:
Bertil Damato

Br J Ophthalmol 2020 May 20. Epub 2020 May 20.

Nuffield Laboratory of Ophthalmology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, UK

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http://dx.doi.org/10.1136/bjophthalmol-2020-316686DOI Listing

Using incognito standardised patients to evaluate quality of eye care in China.

Br J Ophthalmol 2020 May 20. Epub 2020 May 20.

Centre for Public Health, Queen's University Belfast, Belfast, Belfast, UK.

Background/aims: Few studies have objectively examined the quality of eye care in China. We assessed refractive care using the incognito standardised patient (SP) approach, a gold standard for evaluating clinical practice.

Methods: A total of 52 SPs were trained to provide standardised responses during eye examinations, and underwent automated and non-cycloplegic, subjective refraction by a senior ophthalmologist from Zhongshan Ophthalmologic Center, a national-level clinical and research centre. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315103DOI Listing

Comparison of macular structural and vascular changes in neuromyelitis optica spectrum disorder and primary open angle glaucoma: a cross-sectional study.

Br J Ophthalmol 2020 May 19. Epub 2020 May 19.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China

Aims: To compare macular structure and vasculature between neuromyelitis optica spectrum disorder (NMOSD) and primary open angle glaucoma (POAG) using optical coherence tomography angiography.

Methods: NMOSD patients (n=124) with/without a history of optic neuritis (ON) (NMO+ON: 113 eyes; NMO-ON: 95 eyes), glaucomatous patients (n=102) with early/advanced glaucoma (G-E: 74 eyes; G-A: 50 eyes) and healthy controls (n=62; 90 eyes) were imaged. The main outcome measures were macular ganglion cell-inner plexiform layer (GC-IPL) thickness, vessel density (VD) and perfusion density (PD) in the superficial capillary plexus, and diagnostic capabilities of the parameters as calculated by area under the curve (AUC). Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-315842DOI Listing

Effect of plaque brachytherapy dose and dose rate on risk for disease-related mortality in 1238 patients with choroidal melanoma.

Br J Ophthalmol 2020 May 19. Epub 2020 May 19.

St. Erik Eye Hospital, Stockholm, Sweden.

Background: Episcleral brachytherapy is the most common treatment for medium-sized choroidal melanomas. Although controversial, inadequate brachytherapy dose and dose rates have at least a hypothetical implication on patient survival.

Methods: All patients who received ruthenium-106 or iodine-125 brachytherapy for choroidal melanoma at St. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315722DOI Listing

Poor person and areal socioeconomic status is associated with increased diabetic retinopathy and visual impairment incidence and progression.

Br J Ophthalmol 2020 May 19. Epub 2020 May 19.

Singapore Eye Research Institute, Singapore Eye Research Institute, Singapore.

Background: To investigate the longitudinal associations between person-level and area-level socioeconomic status (PLSES and ALSES, respectively) with diabetic retinopathy (DR) and visual impairment (VI) in Asians with diabetes mellitus (DM).

Methods: In this population-based cohort study, we included 468 (39.4%) Malays and 721 (60. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-316430DOI Listing

Long-term effect of YAG laser iridotomy on corneal endothelium in primary angle closure suspects: a 72-month randomised controlled study.

Br J Ophthalmol 2020 May 19. Epub 2020 May 19.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China

Purposes: To evaluate the effect of YAG laser peripheral iridotomy (LPI) on corneal endothelial cell density (ECD) and morphology in primary angle closure suspects (PACS) over 72 months.

Methods: The Zhongshan Angle Closure Prevention Trial is a single-centre randomised controlled trial. Subjects with bilateral PACS received YAG LPI prophylactic treatment in one eye randomly, while the fellow eye served as control. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-315811DOI Listing

Intraocular leucocyte subpopulations analysis by multiparametric flow cytometry in human uveitis.

Br J Ophthalmol 2020 May 18. Epub 2020 May 18.

Ophthalmology Department, Hospital Universitario Fundacion Jimenez Diaz, Madrid, Spain.

Purpose: The aim of this study was to describe the cellular infiltrate in aqueous and vitreous samples of patients with uveitis analysed by multiparametric flow cytometry.

Methods: This is a retrospective analysis of aqueous and vitreous samples analysed by flow cytometry for diagnostic purposes, in cases of masquerade syndromes and infectious and non-infectious uveitis. Data collected included demographics, anatomical classification of uveitis, phenotypic diagnosis, anterior chamber cells grading, vitreous haze and time of follow-up since presentation to sample obtained. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315511DOI Listing

Epidemiology of 2000 Chinese uveitis patients from Northeast China.

Br J Ophthalmol 2020 May 18. Epub 2020 May 18.

Ophthalmologic Center, The Second Hospital of Jilin University, Changchun, China

Aims: To study the clinical characteristics of 2000 patients with uveitis admitted to the ophthalmology centre of the Second Hospital of Jilin University.

Methods: We retrospectively analysed 2000 patients with uveitis who were admitted to the uveitis clinic of the Second Hospital of Jilin University from July 2010 to June 2019 and analysed data on sex, onset age, onset season, anatomical classification, visual acuity and compared the results with those of other investigation studies.

Results: Among 2000 uveitis patients, the mean age of onset was 39. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-316256DOI Listing
May 2020
2.976 Impact Factor

Impact of contact versus non-contact wide-angle viewing systems on outcomes of primary retinal detachment repair (PRO study report number 5).

Br J Ophthalmol 2020 May 14. Epub 2020 May 14.

Mid Atlantic Retina, Wills Eye Hospital, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA

Background/aims: Vitrectomy to repair retinal detachment is often performed with either non-contact wide-angle viewing systems or wide-angle contact viewing systems. The purpose of this study is to assess whether the viewing system used is associated with any differences in surgical outcomes of vitrectomy for primary non-complex retinal detachment repair.

Methods: This is a multicenter, interventional, retrospective, comparative study. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-315948DOI Listing

Novel p.G1344E mutation in is associated with ectopia lentis.

Br J Ophthalmol 2020 May 13. Epub 2020 May 13.

Department of Ophthalmology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Background: Ectopia lentis refers to dislocation or subluxation of the crystalline lens. Fibrillin-1, encoded by , is an important microfibrillar structural component that is specifically required for the suspensory ligament of the lens. mutations may cause abnormal structure of microfibrils and has been associated with a broad spectrum of clinical phenotypes. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315265DOI Listing

Rate of visual field decay in glaucomatous eyes with acquired pits of the optic nerve.

Br J Ophthalmol 2020 May 13. Epub 2020 May 13.

Glaucoma Division, Jules Stein Eye Institute, University of California Los Angeles (UCLA), Los Angeles, California, United States

Background: To evaluate the relationship between the presence of an acquired pit of the optic nerve (APON) and the rate of visual field (VF) decay in primary open-angle glaucoma (POAG).

Methods: Consecutive patients with POAG were screened for APON by three glaucoma specialists. A control group of POAG eyes without APON were matched with the APON group for factors such as age, gender, baseline intraocular pressure and baseline mean deviation (MD). Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-315980DOI Listing

Diagnostic accuracy of diabetic retinopathy grading by an artificial intelligence-enabled algorithm compared with a human standard for wide-field true-colour confocal scanning and standard digital retinal images.

Br J Ophthalmol 2020 May 6. Epub 2020 May 6.

Diabetes, Homerton University Hospital NHS Foundation Trust, London, UK.

Background: Photographic diabetic retinopathy screening requires labour-intensive grading of retinal images by humans. Automated retinal image analysis software (ARIAS) could provide an alternative to human grading. We compare the performance of an ARIAS using true-colour, wide-field confocal scanning images and standard fundus images in the English National Diabetic Eye Screening Programme (NDESP) against human grading. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315394DOI Listing

Henle fibre layer haemorrhage: clinical features and pathogenesis.

Br J Ophthalmol 2020 May 6. Epub 2020 May 6.

Retina Department, Vitreous Retina Macula Consultants of New York, New York, New York, USA.

Background: To describe the clinical presentation and characteristic imaging features of deep retinal haemorrhages primarily located in the Henle fibre layer (HFL) of the macula. The spectrum of aetiologies and a comprehensive theory of pathogenesis are presented.

Methods: This is a retrospective, multicentre case series evaluating eyes with retinal haemorrhage in HFL. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315443DOI Listing

iOCT-assisted macular hole surgery: outcomes and utility from the DISCOVER study.

Br J Ophthalmol 2020 May 6. Epub 2020 May 6.

The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cole Eye Institute, Cleveland, Ohio, USA

Background/aims: This study aimed to characterise the clinical outcomes and utility of intraoperative optical coherence tomography (iOCT)-assisted macular hole (MH) repair.

Methods: This was a post hoc analysis of eyes in the etermination of feasibility of ntraoperative pectral domain microscope ombined/integrated CT isualization during n face etinal and ophthalmic surgery (DISCOVER) study undergoing surgical MH repair with use of iOCT. Functional and surgical outcome data were collected through 12 months postoperatively. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-316045DOI Listing

Factors affecting the diagnostic performance of circumpapillary retinal nerve fibre layer measurement in glaucoma.

Br J Ophthalmol 2020 May 5. Epub 2020 May 5.

SERI-NTU Advanced Ocular Engineering (STANCE) Program, Singapore

Background/aims: To identify factors that influence the diagnostic performance of circumpapillary retinal nerve fibre layer (RNFL) thickness measurements in the detection of primary open-angle glaucoma (POAG).

Methods: 1592 eyes from 1076 healthy controls and 758 eyes from 502 patients with POAG underwent optical coherence tomography (OCT) imaging to assess RNFL parameters. Visual field (VF) mean deviation (MD) from standard automated perimetry was used to indicate severity in subjects with glaucoma. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-315985DOI Listing

Retinal light sensitivity as outcome measure in recessive Stargardt disease.

Br J Ophthalmol 2020 Apr 28. Epub 2020 Apr 28.

Department of Ophthalmology, University of Bonn, Bonn, Germany

Background/aims: To evaluate the applicability of mesopic light sensitivity measurements obtained by fundus-controlled perimetry (FCP, also termed 'microperimetry') as clinical trial endpoint in Stargardt disease (STGD1).

Methods: In this retrospective, monocentre cohort study, 271 eyes of 136 patients (age, 37.1 years) with STGD1 and 87 eyes of 54 healthy controls (age, 41. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-316201DOI Listing

Morphological characteristics of parapapillary atrophy and subsequent visual field progression in primary open-angle glaucoma.

Br J Ophthalmol 2020 Apr 28. Epub 2020 Apr 28.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul, South Korea

Background/aims: To investigate the associations between the morphological characteristics of beta-zone parapapillary atrophy (β-zone PPA) and subsequent visual field (VF) progression in eyes with primary open-angle glaucoma (POAG).

Methods: One hundred and twenty-one POAG eyes with β-zone PPA along with 48 normal eyes with β-zone PPA were included. β-zone PPA area was calculated based on the PPA pixel area/optic-disc pixel area ratio and the optical coherence tomography (OCT)-measured disc area. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315477DOI Listing
April 2020
2.976 Impact Factor

Correlation of ocular rigidity with intraocular pressure spike after intravitreal injection of bevacizumab in exudative retinal disease.

Br J Ophthalmol 2020 Apr 28. Epub 2020 Apr 28.

Ophthalmology, Maisonneuve-Rosemont Hospital Research Centre, Montreal, Quebec, Canada

Background/aims: To evaluate the non-invasive measurement of ocular rigidity (OR), an important biomechanical property of the eye, as a predictor of intraocular pressure (IOP) elevation after anti-vascular endothelial growth factor (anti-VEGF) intravitreal injection (IVI).

Methods: Subjects requiring IVI of anti-VEGF for a pre-existing retinal condition were enrolled in this prospective cross-sectional study. OR was assessed in 18 eyes of 18 participants by measurement of pulsatile choroidal volume change using video-rate optical coherence tomography, and pulsatile IOP change using dynamic contour tonometry. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315595DOI Listing
April 2020
2.976 Impact Factor

Ocular toxoplasmosis: phenotype differences between toxoplasma IgM positive and IgM negative patients in a large cohort.

Br J Ophthalmol 2020 Apr 28. Epub 2020 Apr 28.

Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust, London, London, UK.

Purpose: To investigate the differences in demographics and clinical characteristics of patients diagnosed with ocular toxoplasmosis according to their IgM status.

Methods: Retrospective case note analysis was carried out on patients who tested positive for serum -specific IgM antibodies (IgM+) as well as a comparator group who tested negative for serum IgM (IgM-), but positive for serum IgG. Patient demographics and clinical features were compared between the two groups to evaluate for any significant differences. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315522DOI Listing

Prognostic factors for relapse and survival among patients with ocular adnexal lymphoma: validation of the eighth edition of the American Joint Committee on Cancer (AJCC) TNM classification.

Br J Ophthalmol 2020 Apr 23. Epub 2020 Apr 23.

Department of Ophthalmology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

Background/aims: To validate the prognostic performance of the American Joint Committee on Cancer (AJCC) eighth edition classification for ocular adnexal lymphoma (OAL).

Methods: We performed a retrospective review of 140 consecutive patients treated for primary OAL between March 2010 and September 2017. Associations between T/N/M categories at presentation and disease-related outcomes, including relapse, progression-free survival (PFS) and overall survival (OS) were evaluated. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-315875DOI Listing

Allogenic simple limbal epithelial transplantation (alloSLET) from cadaveric donor eyes in patients with persistent corneal epithelial defects.

Br J Ophthalmol 2020 Apr 23. Epub 2020 Apr 23.

Department of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Rheinland-Pfalz, Germany.

Background/aim: To describe the clinical outcome of allogenic simple limbal epithelial transplantation (alloSLET) utilising tissue from cadaveric donor eyes after failed re-epithelialisation of the corneal surface.

Methods: Medical records of 14 eyes from 14 patients treated for persistent corneal epithelial defects with alloSLET were reviewed. The primary outcome measure was complete epithelialisation of the corneal surface. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315176DOI Listing

Eye trauma in falls presenting to the emergency department from 2006 through 2015.

Br J Ophthalmol 2020 Apr 23. Epub 2020 Apr 23.

Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA

Aims: To characterise the epidemiology of eye trauma in the event of falls presenting to the emergency departments (ED) in the USA.

Method: Retrospective cohort study. Nationwide Emergency Department Sample was used to analyse fall encounters presenting to the ED with eye trauma from 2006 to 2015. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-314669DOI Listing
April 2020
2.976 Impact Factor

Effect of long-term rigid gas-permeable contact lens wear on keratoconus progression.

Br J Ophthalmol 2020 Apr 21. Epub 2020 Apr 21.

Ophthalmology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Background/aims: To investigate the chronological corneal changes associated with long-term rigid gas-permeable contact lens (RGP-CL) wear in patients with keratoconus (KC).

Methods: Clinical records of 405 patients with KC or with KC suspect were retrospectively reviewed. Patients with mild-to-moderate KC and uneventful follow-up were classified into the CL (RGP-CL wear) and non-CL (without CL wear) groups. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-315942DOI Listing

Long-term outcomes of treat-and-extend ranibizumab with and without navigated laser for diabetic macular oedema: TREX-DME 3-year results.

Br J Ophthalmol 2020 Apr 17. Epub 2020 Apr 17.

The Methodist Hospital, Houston, TX, Houston, Texas, USA.

Background/aims: To evaluate the long-term effects of treat-and-extend dosing of ranibizumab with and without navigated focal laser for diabetic macular oedema (DME).

Methods: This is a multicentre, randomised clinical trial where 150 eyes were randomised into three cohorts; Monthly (n=30), TReat and EXtend without macular laser photocoagulation (TREX; n=60), and treat and extend with angiography-GuIded macular LAser photocoagulation (GILA; n=60). During the first 2 years, eyes either received ranibizumab 0. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-316176DOI Listing

Puberty could regulate the effects of outdoor time on refractive development in Chinese children and adolescents.

Br J Ophthalmol 2020 Apr 16. Epub 2020 Apr 16.

Department of Preventative Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai, China

Aim: To explore the impact of puberty on refractive development and its interaction with outdoor time in children and adolescents.

Methods: In this 2-year observational study, students aged 7-13 years were selected with cluster sampling. All participants underwent cycloplegic refraction and axial length measurements once every year. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315636DOI Listing

Not the 2020 we asked for.

Br J Ophthalmol 2020 Jun 10;104(6):741. Epub 2020 Apr 10.

Ophthalmology, Massachusetts Eye and Ear, Howe Laboratory, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1136/bjophthalmol-2020-316403DOI Listing

Ophthalmic statistics note 14: method agreement studies in ophthalmology: the intraclass correlation coefficient?

Br J Ophthalmol 2020 Apr 10. Epub 2020 Apr 10.

Institute of Clinical Trials and Methodology, University College London, London, UK.

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http://dx.doi.org/10.1136/bjophthalmol-2019-314947DOI Listing

Prognostic significance of immune checkpoints in the tumour-stromal microenvironment of sebaceous gland carcinoma.

Br J Ophthalmol 2020 Apr 10. Epub 2020 Apr 10.

Ocular Pathology, All India Institute of Medical Sciences, New Delhi, Delhi, India

Background: Immune checkpoint blockade strategies have gained attention in the treatment/prognosis of cancers by targeting the programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) pathway alone or in combination with cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) blockade and are currently in clinical trials. The present study investigated the expression of the PD-1, PD-L1, CTLA-4, CD4 and CD8 proteins and their prognostic value in the tumour microenvironment of sebaceous gland carcinoma (SGC).

Methods: The expression levels of PD-1, PD-L1, CTLA-4, CD4 and CD8 proteins were assessed in 52 cases of SGC by immunohistochemistry and validated by western blotting. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315490DOI Listing
April 2020
2.976 Impact Factor

Intraocular pressure changes following topical ocular hypotensive medications washout.

Br J Ophthalmol 2020 Apr 10. Epub 2020 Apr 10.

Department of Ophthalmology, St. Thomas' Hospital, London, UK

Background: To review the changes in intraocular pressure (IOP) following topical hypotensive medications washout in patients with primary open angle glaucoma (POAG), ocular hypertension (OHT) and uveitic glaucoma (UG)/OHT.

Methods: The study included 120 patients with POAG, OHT and UG recruited from prospective clinical trials between February 2013 and July 2017. We excluded 20 eyes with IOP of ≤21 mm Hg, 11 eyes with previous incisional surgery and 17 eyes with incomplete data. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315778DOI Listing

Morphological change and recovery of corneal endothelial cells after rho-associated protein kinase inhibitor eye-drop (ripasudil 0.4%) instillation.

Br J Ophthalmol 2020 Apr 8. Epub 2020 Apr 8.

Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Background/aims: To investigate the time-dependent change of corneal endothelial cell (CEC) morphology and density (CECD) in patients with glaucoma post instillation of rho-associated protein kinase inhibitor ripasudil (Rip) 0.4% eye drops.

Methods: This observational study involved 163 eyes of 163 patients with glaucoma in whom CEC morphological change was evaluated by CECD calculated via non-contact specular microscopy (NCSM) before and at 1 or 3 months post-Rip instillation. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315776DOI Listing

Prognostic value of intermediate age-related macular degeneration phenotypes for geographic atrophy progression.

Br J Ophthalmol 2020 Apr 8. Epub 2020 Apr 8.

Department of Ophthalmology, University of Bonn, Bonn, Nordrhein-Westfalen, Germany.

Background: To characterise early stages of geographic atrophy (GA) development in age-related macular degeneration (AMD) and to determine the prognostic value of structural precursor lesions in eyes with intermediate (i) AMD on the subsequent GA progression.

Methods: Structural precursor lesions for atrophic areas (lesion size at least 0.5 mm² in fundus autofluorescence images) were retrospectively identified based on multimodal imaging and evaluated for association with the subsequent GA enlargement rates (square-root transformed, sqrt). Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-316004DOI Listing

Gene therapy for neovascular age-related macular degeneration: rationale, clinical trials and future directions.

Br J Ophthalmol 2020 Apr 8. Epub 2020 Apr 8.

UCL Institute of Ophthalmology, University College London, London, UK

Age-related macular degeneration (AMD) is one of the leading causes of irreversible blindness in the developed world. Antivascular endothelial growth factor therapy has transformed the management and outcome of neovascular AMD (nAMD), although the need for repeated intravitreal injections-even lifelong-and the related complications, high drug costs, frequent clinic visits and repeated imaging have resulted in an enormous burden both to healthcare systems and patients. The application of gene therapy approaches for sustained delivery of a range of antiangiogenic proteins has the promise of helping to address these aforementioned challenges. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-316195DOI Listing

Ocular manifestations of a hospitalised patient with confirmed 2019 novel coronavirus disease.

Br J Ophthalmol 2020 06 7;104(6):748-751. Epub 2020 Apr 7.

Ophthalmology, Shenzhen Eye Hospital, Shenzhen, China.

Purpose: To report the ocular characteristics and the presence of viral RNA of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in conjunctival swab specimens in a patient with confirmed 2019 novel coronavirus disease (COVID-19).

Participant And Methods: A 30-year-old man with confirmed COVID-19 and bilateral acute conjunctivitis which occurred 13 days after illness onset. Based on detailed ophthalmic examination, reverse transcription PCR (RT-PCR) was performed to detect SARS-CoV-2 virus in conjunctival swabs. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-316304DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211077PMC
June 2020
2.976 Impact Factor

Visual acuity outcomes and anti-VEGF therapy intensity in diabetic macular oedema: a real-world analysis of 28 658 patient eyes.

Br J Ophthalmol 2020 Apr 7. Epub 2020 Apr 7.

University of Minnesota, Minneapolis, Minnesota, USA.

Background/aim: To assess visual acuity (VA) outcomes and antivascular endothelial growth factor (anti-VEGF) treatment intensity in diabetic macular oedema (DMO).

Methods: Retrospective analysis was performed in treatment-naïve patients with DMO from 2013 to 2018 using a database of aggregated de-identified electronic medical records (Vestrum Health).

Results: At 1 year, 28 658 patient eyes underwent a mean of 6. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-315933DOI Listing
April 2020
2.976 Impact Factor

Optical coherence tomography angiography of flat irregular pigment epithelial detachments in central serous chorioretinopathy.

Br J Ophthalmol 2020 Apr 7. Epub 2020 Apr 7.

Shandong Eye Hospital, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.

Background: To identify and analyse the character and relationship between flat irregular pigment epithelial detachment feature (FIPED), choroidal thickness and choroidal neovascularisation (CNV) network seen on optical coherence tomography angiography (OCTA) in eyes with central serous chorioretinopathy (CSCR) in Chinese patients.

Method: In the present study, 152 eyes of 144 Chinese patients, who were previously diagnosed with CSCR, were retrospectively studied. Patients' baseline characteristics, the course of CSCR, best-corrected visual acuity, the pattern of CNV on OCTA, FIPED and choroidal thickness detected by enhanced depth imaging-OCT (EDI-OCT) were analysed. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315318DOI Listing

Vision loss in anterior uveitis.

Br J Ophthalmol 2020 Apr 3. Epub 2020 Apr 3.

Ophthalmology, Greenlane Clinical Centre, Auckland, New Zealand

Aims: To evaluate the long-term risk of permanent vision loss in subjects with anterior uveitis.

Methods: Retrospective study of subjects attending uveitis clinic at Auckland District Health Board and Moorfields Eye Hospital between 2008 and 2018. Main outcome measures were: best corrected visual acuity (BCVA); moderate vision loss (MVL ≤20/50); and severe vision loss (SVL ≤20/200). Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315551DOI Listing

Visual outcomes after surgery for primary rhegmatogenous retinal detachment in era of microincision vitrectomy: Japan-Retinal Detachment Registry Report IV.

Br J Ophthalmol 2020 Apr 3. Epub 2020 Apr 3.

Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

Background/aim: To determine the preoperative ocular factors and surgical methods that led to best-corrected visual acuity (BCVA) after pars plana vitrectomy (PPV) or scleral buckling (SB) for rhegmatogenous retinal detachment (RRD).

Methods: This was a prospective, nationwide, multicentre, observational study. Data from the Japanese Retina and Vitreous Society registry from 2016 to 2017 were used to determine the association between preoperative clinical factors, surgical procedures and postoperative BCVA at 6 months. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-315945DOI Listing

Bilateral morphometric analysis of corneal sub-basal nerve plexus in patients undergoing unilateral cataract surgery: a preliminary in vivo confocal microscopy study.

Br J Ophthalmol 2020 Apr 3. Epub 2020 Apr 3.

Department of Neuroscience Rehabilitation Ophthalmology Genetics and Maternal and Child Health Genova, University of Genoa, Genova, Italy.

Aims: To evaluate bilateral morphometric changes of corneal sub-basal nerve plexus (CSNP) occurring after unilateral cataract surgery by in vivo confocal microscopy (IVCM) images analysed with automated software.

Methods: IVCM was performed before (V0) and 1 month after surgery (V1) in both operated eyes (OEs) and unoperated eyes (UEs) of 30 patients. Thirty age and sex-matched subjects acted as controls. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315449DOI Listing

Clinical and genetical features of probands and affected family members with familial exudative vitreoretinopathy in a large Chinese cohort.

Br J Ophthalmol 2020 Apr 1. Epub 2020 Apr 1.

Ophthalmology, Shanghai Jiaotong University School of Medicine Xinhua Hospital, Shanghai, China

Aims: To explore the clinical and genetical features of families with strictly confirmed familial exudative vitreoretinopathy (FEVR) in a large Chinese cohort.

Methods: A retrospective chart review study was conducted on the FEVR families diagnosed by both angiography and targeted next-generation sequencing in six FEVR known genes (, , , , ) in the probands and at least one first-degree family member. Variation in expressivity and severity was evaluated in different gene groups. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315598DOI Listing

Prevalence and causes of vision loss in sub-Saharan Africa in 2015: magnitude, temporal trends and projections.

Br J Ophthalmol 2020 Mar 30. Epub 2020 Mar 30.

Vision and Eye Research Unit (VERI), Anglia Ruskin University, Chelmsford, UK

Background: This study aimed to assess the prevalence and causes of vision loss in sub-Saharan Africa (SSA) in 2015, compared with prior years, and to estimate expected values for 2020.

Methods: A systematic review and meta-analysis assessed the prevalence of blindness (presenting distance visual acuity <3/60 in the better eye), moderate and severe vision impairment (MSVI; presenting distance visual acuity <6/18 but ≥3/60) and mild vision impairment (MVI; presenting distance visual acuity <6/12 and ≥6/18), and also near vision impairment (Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315217DOI Listing
March 2020
2.976 Impact Factor

Naevus of Ota: clinical characteristics and proposal for a new ocular classification and grading system.

Br J Ophthalmol 2020 Mar 30. Epub 2020 Mar 30.

Goldschleger Eye Institute, Sheba Medical Center, Tel Hashomer, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer, Israel.

Introduction: Naevus of Ota is a congenital condition that may involve the skin, eyeball and even intracranial structures usually in the distribution of the ophthalmic and maxillary divisions of the trigeminal cranial nerve. The purpose of this study was to summarise our experience with the ocular clinical presentation, imaging, outcome, treatment of complications and to offer a new classification of patients with naevus of Ota.

Methods: We retrospectively reviewed the patients' medical records and the following parameters were retrieved and analysed: demographics, clinical presentation complications and treatment of complications. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-313984DOI Listing

OCT-A characterisation of recurrent type 3 macular neovascularisation.

Br J Ophthalmol 2020 Mar 30. Epub 2020 Mar 30.

School of Medicine, Vita-Salute San Raffaele University, Milan, Italy

Purpose: To investigate optical coherence tomography angiography (OCT-A) findings in recurrent type 3 macular neovascularisation (MNV).

Methods: In this retrospective cohort study, consecutive patients with type 3 MNV secondary to age-related macular degeneration underwent OCT-A at three different time points: baseline, after anti-vascular endothelial growth factor treatment with complete resolution of the exudative signs (ie, non-exudative stage) and at the recurrence of exudation (ie, recurrence stage). Demographics and clinical findings were analysed, including OCT-A features of type 3 MNV recurrence. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2020-316054DOI Listing
March 2020
2.976 Impact Factor

Clinical and laboratory characteristics of ocular syphilis and neurosyphilis among individuals with and without HIV infection.

Br J Ophthalmol 2020 Mar 27. Epub 2020 Mar 27.

Department of Ophthalmology, Tygerberg Hospital, Cape Town, South Africa.

Background/aims: In the era of increasing incidence of syphilis globally, ocular syphilis is re-emerging as an important cause of uveitis. The aim of this study was to determine the clinical and laboratory characteristics of ocular- and neurosyphilis among individuals with and without HIV infection.

Methods: Retrospective analysis of patients diagnosed with ocular syphilis presenting to Tygerberg Hospital, South Africa, over a 5-year period ending December 2018. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315699DOI Listing

Shaped corneal transplantation surgery.

Br J Ophthalmol 2020 Mar 25. Epub 2020 Mar 25.

Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia

Since its inception in 1905, keratoplasty techniques have continuously evolved. Shaped keratoplasty procedures have allowed corneal surgeons to use complex graft-host junctions and non-circular graft designs to optimise wound strength and healing, facilitate early suture removal and expedite visual rehabilitation. While this was initially limited to penetrating procedures, shaped lamellar keratoplasty techniques have since emerged. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315754DOI Listing
March 2020
2.976 Impact Factor

Retinoblastoma in Finland, 1964-2014: incidence and survival.

Br J Ophthalmol 2020 Mar 25. Epub 2020 Mar 25.

Department of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.

Aims: To determine the incidence of retinoblastoma (Rb) and subsequent survival in the Finnish population during five decades.

Methods: This retrospective observational cohort study comprised all patients with Rb born in Finland during 19642014 and diagnosed in 2018 (birth cohort analysis) or diagnosed in 19642014 (standard annual analysis), identified from the Finnish Cancer Registry and the national referral centre. We report age-adjusted incidences and survival according to cause of death. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315744DOI Listing

Prevalence and risk factors for visual impairment among elderly residents in 'homes for the aged' in India: the Hyderabad Ocular Morbidity in Elderly Study (HOMES).

Br J Ophthalmol 2020 Mar 25. Epub 2020 Mar 25.

Massachusetts Eye and Ear, Harvard Medical School Department of Ophthalmology, Boston, United States.

Background/aim: To investigate the prevalence, causes and risk factors of visual impairment (VI) among the elderly in 'home for the aged' in Hyderabad, India.

Methods: Individuals aged ≥60 years were recruited from 41 'homes for the aged'. All participants had complete eye examinations including presenting visual acuity, refraction, slit-lamp examination, intraocular pressure measurement and fundus imaging by trained clinicians. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-315678DOI Listing