20,230 results match your criteria British Journal of Ophthalmology[Journal]


Decreased contrast sensitivity at high altitude.

Br J Ophthalmol 2019 Feb 15. Epub 2019 Feb 15.

Department of Ophthalmology, Katharinenhospital Stuttgart, Stuttgart, Germany

Background/aims: The aim of this study was to investigate a change in visual acuity and contrast sensitivity (CS) during high altitude exposure in healthy subjects due to the effects of hypobaric hypoxia. This study is related to the Tübingen High Altitude Ophthalmology study.

Methods: Visual acuity and Weber CS were tested monocularly using the Freiburger Visual Acuity and Contrast Test under standardised conditions in 14 healthy subjects at high altitude at the Capanna Margherita (4559 m, Italy) and compared with baseline measurements in Tübingen (341 m, Germany). Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313260DOI Listing
February 2019

Prevalence and risk factors of myopic maculopathy in rural southern China: the Yangxi Eye Study.

Br J Ophthalmol 2019 Feb 15. Epub 2019 Feb 15.

State Key Laboratory of Ophthalmology, Sun Yat-Sen University Zhongshan Ophthalmic Center, Guangzhou, China

Aims: To evaluate the prevalence of myopic maculopathy among participants aged 50 years and older in rural southern China.

Methods: Population-based, cross-sectional study. Subjects were recruited using cluster sampling from Yangxi County, Guangdong Province, China from August to November in 2014. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313057DOI Listing
February 2019

Treatment of neurotrophic keratopathy with minimally invasive corneal neurotisation: long-term clinical outcomes and evidence of corneal reinnervation.

Br J Ophthalmol 2019 Feb 15. Epub 2019 Feb 15.

Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Aim: To report clinical outcomes and evidence of corneal innervation in patients with neurotrophic keratopathy (NK) treated with minimally invasive corneal neurotisation (MICN) using a sural nerve graft and donor sensory nerves from the face.

Methods: Patients undergoing MICN at The Hospital for Sick Children, Toronto, Canada were prospectively recruited. Data on central corneal sensation (CCS, measured with Cochet-Bonnet aesthesiometer), best-corrected visual acuity (BCVA) and corneal epithelial integrity were collected. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313042DOI Listing
February 2019

Outcomes of small-gauge vitreoretinal surgery without scleral-depressed shaving of the vitreous base in the era of wide-angle viewing systems.

Br J Ophthalmol 2019 Feb 15. Epub 2019 Feb 15.

Ophthalmology, Bascom Palmer Eye Institute, Miami, Florida, USA.

Purpose: To evaluate outcomes of small-gauge pars plana vitrectomy (PPV) for the treatment of rhegmatogenous retinal detachment (RD) without scleral-depressed shaving of the vitreous base.

Methods: Retrospective, consecutive case series. Surgical technique included small-gauge PPV (25G, 23G, 25G+ or 27G) and wide-angle vitrectomy viewing system in all cases. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313626DOI Listing
February 2019

Philadelphia Telemedicine Glaucoma Detection and Follow-up Study: confirmation between eye screening and comprehensive eye examination diagnoses.

Br J Ophthalmol 2019 Feb 15. Epub 2019 Feb 15.

Glaucoma Service, Wills Eye Hospital, Philadelphia, Pennsylvania, USA.

Aims: To evaluate agreement between ocular findings of a telemedicine eye screening (visit 1) with diagnoses of a comprehensive eye examination (visit 2).

Methods: A primary care practice (PCP)-based telemedicine screening programme incorporating fundus photography, intraocular pressure (IOP) and clinical information was conducted. Eligible individuals were African American, Hispanic/Latino or Asian over the age of 40; Caucasian individuals over age 65; and adults of any ethnicity over age 40 with a family history of glaucoma or diabetes. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313451DOI Listing
February 2019
1 Read

Recurrent corneal erosion syndrome.

Br J Ophthalmol 2019 Feb 13. Epub 2019 Feb 13.

Ophthalmology, Massachusetts Eye and Ear, Howe Laboratory, Harvard Medical School, Boston, Massachusetts, USA

Recurrent corneal erosion syndrome (RCES) is a disorder characterised by a dysfunctional epithelial ecosystem. It often begins after trauma, or in the setting of epithelial basement membrane degeneration or dystrophy. Historically, RCES has been understood as a structural derangement of the anterior corneal architecture. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2019-313835DOI Listing
February 2019

Iris colour and astigmatism among Chinese teenagers.

Br J Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

Department of Ophthalmology, The First Affiliated Hospital of Kunming Medical University, Kunming, China

Background/aims: Iris colour might contribute to refractive development, but it is uncertain whether it is related to astigmatism. We aim to examine the association of iris colour with the presence of astigmatism in a school-based sample of Chinese students.

Methods: 2346 grade 7 students from 10 middle schools aged 13 to 14 years in Southwestern China participated in the study. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3133
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http://dx.doi.org/10.1136/bjophthalmol-2018-313357DOI Listing
February 2019
3 Reads

Dexamethasone implant for non-infectious uveitis: is it cost-effective?

Br J Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

Background: Uveitis is inflammation inside the eye. The objective of this study is to assess the cost-effectiveness of a dexamethasone implant plus current practice (immunosuppressants and systemic corticosteroids) compared with current practice alone, in patients with non-infectious intermediate, posterior or pan-uveitis and to identify areas for future research.

Methods: A Markov model was built to estimate the costs and benefits of dexamethasone. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3127
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http://dx.doi.org/10.1136/bjophthalmol-2018-312765DOI Listing
February 2019
1 Read
2.976 Impact Factor

Non-invasive diagnosis of retinoblastoma using cell-free DNA from aqueous humour.

Br J Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

West Midlands Regional Genetics Service, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.

Retinoblastoma is the most common eye malignancy in childhood caused by mutations in the gene. Both alleles of the gene must be mutated for tumour development. The initial mutation may be constitutional germline or somatic (originating in one retinal cell only). Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3130
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http://dx.doi.org/10.1136/bjophthalmol-2018-313005DOI Listing
February 2019
1 Read

Risk factors associated with myopia in schoolchildren in Ireland.

Br J Ophthalmol 2019 Feb 11. Epub 2019 Feb 11.

School of Physics and Clinical and Optometric Sciences, Technological University Dublin, Dublin, Ireland.

Aim: To examine the demographic and social factors associated with myopia in schoolchildren in Ireland.

Methods: Thirty-seven schools participated, representing a mix of urban and rural schools and schools in socioeconomically disadvantaged and non-disadvantaged areas in Ireland. Examination included cyclopleged autorefraction (1% cyclopentolate hydrochloride). Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313325DOI Listing
February 2019

ACE inhibitor use and risk of cataract: a case-control analysis.

Br J Ophthalmol 2019 Feb 7. Epub 2019 Feb 7.

Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland

Background/aim: Use of ACE inhibitors (ACEIs) has been associated with an increased risk of cataract in a previous observational study in humans. In contrast, ACEIs were associated with beneficial effects on cataract development in experimental studies. We assessed the risk of cataract in relation to exposure to ACEI and other antihypertensive drugs. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-312980DOI Listing
February 2019

Long-term outcomes of penetrating keratoplasty for corneal complications of herpes zoster ophthalmicus.

Br J Ophthalmol 2019 Feb 7. Epub 2019 Feb 7.

W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, USA.

Background/aim: To review the long-term outcomes of penetrating keratoplasty (PKP) for corneal complications of herpes zoster ophthalmicus (HZO).

Methods: We reviewed the medical records of 53 eyes of 53 patients who underwent PKP due to corneal complications of HZO at the Kellogg Eye Center.

Results: The mean age of patients at the time of PKP was 68. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3136
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http://dx.doi.org/10.1136/bjophthalmol-2018-313602DOI Listing
February 2019
3 Reads

Adalimumab for non-infectious uveitis: is it cost-effective?

Br J Ophthalmol 2019 Feb 6. Epub 2019 Feb 6.

Department of Opthalmology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Background/aims: Uveitis is inflammation inside the eye. Our objective was to assess the cost-effectiveness of adalimumab compared with current practice (immunosuppressants and systemic corticosteroids) in patients with non-infectious intermediate, posterior or panuveitis and to identify areas for future research.

Methods: A Markov model was built to estimate costs and benefits of the interventions. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3127
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http://dx.doi.org/10.1136/bjophthalmol-2018-312756DOI Listing
February 2019
2 Reads

Diagnostic performance of optical coherence tomography angiography in glaucoma: a systematic review and meta-analysis.

Br J Ophthalmol 2019 Feb 6. Epub 2019 Feb 6.

Department of Community Medicine, Center for Health Technology and Services Research (CINTESIS), Information and Health Decision Sciences (MEDCIDS), University of Porto, Oporto, Portugal.

Background: Compared with current imaging methods, the diagnostic performance and the advantages and limitations of optical coherence tomography angiography (OCTA) remain unclear. We performed a systematic review and meta-analysis of studies investigating vessel density (VD) in patients with glaucoma using OCTA.

Methods: We conducted a literature search on PubMed, Scopus, Web of Science, ISI Conference Proceedings and Google Scholar, along with a manual search, from January 2006 to March 2018. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313461DOI Listing
February 2019

Six-year incidence and progression of diabetic retinopathy in Indian adults: the Singapore Indian Eye study.

Br J Ophthalmol 2019 Feb 2. Epub 2019 Feb 2.

Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore

Aims: Diabetes is a major public health problem in migrants and ethnic minorities worldwide. We determined the incidence and risk factors of diabetic retinopathy (DR) in migrant Indians living in Singapore.

Methods: We included data from 759 Indian adults with diabetes, who participated in the baseline (aged 40-80 years, 2007-2009) and 6-year follow-up 2012-2015 of the Singapore Indian Eye Study. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313282DOI Listing
February 2019
2 Reads
2.976 Impact Factor

Clinical and microbiological characteristics of Moraxella keratitis.

Br J Ophthalmol 2019 Feb 1. Epub 2019 Feb 1.

Ophthalmology, Royal Victoria Eye and Ear Hospital, Dublin, Ireland

Background/aims: To describe the risk factors, clinical features, bacterial subspecies characteristics and treatment outcomes of Moraxella keratitis in a single centre.

Methods: A retrospective review of all patients diagnosed with Moraxella keratitis between November 2012 and December 2017 at the Royal Victoria Eye and Ear Hospital, Dublin, Ireland was performed. Matrix-assisted laser desorption ionisation time-of-flight (MALDI-TOF) mass spectrometry was used to identify subspecies. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313557DOI Listing
February 2019

Microperimetry in age-related macular degeneration: association with macular morphology assessed by optical coherence tomography.

Br J Ophthalmol 2019 Feb 1. Epub 2019 Feb 1.

Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA.

Background/aims: Microperimetry is a technique that is increasingly used to assess visual function in age-related macular degeneration (AMD). In this study, we aimed to evaluate the relationship between retinal sensitivity measured with macular integrity assessment (MAIA) microperimetry and optical coherence tomography (OCT)-based macular morphology in AMD.

Methods: Prospective, cross-sectional study. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313316DOI Listing
February 2019

Pyogenic granuloma associated with conjunctival epithelial neoplasia: report of nine cases.

Br J Ophthalmol 2019 Feb 1. Epub 2019 Feb 1.

Eye Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Aims: To systematically describe the clinical and histopathological features of a case series of conjunctival carcinomatous lesions underlying as-and also masquerading-pyogenic granuloma.

Methods: Nine cases of conjunctival carcinomatous lesions underlying a pyogenic granuloma (which were clinically predominant) were retrospectively identified. Patients' records were analysed for demographic data, clinical appearance and the postoperative course. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3129
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http://dx.doi.org/10.1136/bjophthalmol-2018-312960DOI Listing
February 2019
4 Reads

Aurora borealis and string of pearls in vitreoretinal lymphoma: patterns of vitreous haze.

Br J Ophthalmol 2019 Feb 1. Epub 2019 Feb 1.

Department of Ophthalmology, San Raffaele Scientific Institute, University Vita-Salute, Milan, Italy.

Aims: Peculiar retinal signs of vitreoretinal lymphoma (VRL) have been identified. However, limited information on the vitreous features of VRL is available. This study aims to characterise the vitreous involvement in VRL with the help of multimodal imaging. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313491DOI Listing
February 2019

Refractory follicular conjunctival lesions: overlook as just inflammation or not?

Br J Ophthalmol 2019 Feb 1. Epub 2019 Feb 1.

Department of Ophthalmology and Visual Science, Seoul St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea

Purpose: To report the clinical manifestations of 199 patients with suspected conjunctival lymphoma, the associations between these features and the pathological diagnoses, and the prognosis of conjunctival lesions during long-term follow-up.

Methods: We conducted a retrospective chart review of 199 patients who underwent conjunctival biopsy on suspicion of conjunctival lymphoproliferative disease between January 2008 and June 2015. We focused on slit-lamp findings in the conjunctiva and the pathological diagnoses. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-312836DOI Listing
February 2019
1 Read

Association of human antigen class I genes with cold medicine-related Stevens-Johnson syndrome with severe ocular complications in a Korean population.

Br J Ophthalmol 2019 Jan 31. Epub 2019 Jan 31.

Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan

Background/aims: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are a spectrum of diseases that cause an acute vesiculobullous reaction in the skin and mucous membranes. The occurrence of these diseases is associated with various drugs, a large proportion of which is comprised cold medicines (CM). We try to investigate the association between human leucocyte antigen (HLA) class I genes and CM-related SJS/TEN (CM-SJS/TEN) with severe ocular complications (SOC) in the Korean population. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313263DOI Listing
January 2019
1 Read

Risk-stratified systemic surveillance in uveal melanoma.

Br J Ophthalmol 2019 Jan 31. Epub 2019 Jan 31.

Cole Eye Institute, Cleveland, Ohio, USA

Background/aim: Molecular prognostication provides clinically applicable prognostic information for patients with uveal melanoma. Most ocular oncologists recommend intensive metastatic surveillance for patients with high-risk tumours. However, socioeconomic variables may limit a patient's ability to adhere to recommended surveillance. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3135
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http://dx.doi.org/10.1136/bjophthalmol-2018-313569DOI Listing
January 2019
3 Reads

Areal summed corneal power shift is an important determinant for axial length elongation in myopic children treated with overnight orthokeratology.

Br J Ophthalmol 2019 Jan 31. Epub 2019 Jan 31.

State Key Laboratory of Ophthalmology, Zhongshan Opthalmic Center, Sun Yat-Sen University, Guangzhou, China

Background: The myopia control effect of orthokeratology (OK) varies among individuals. The variation might relate to the proposed 'areal summation effect' of lens-induced visual signals. The current study evaluated the areal summed corneal power shift (ASCPS) in myopic children treated with OK lenses and assessed whether the ASCPS achieved at early post-OK visit can predict the lens long-term effect on the axial length (AL) elongation. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-312933DOI Listing
January 2019

Retinal microvascular abnormalities in neurofibromatosis type 1.

Br J Ophthalmol 2019 Jan 31. Epub 2019 Jan 31.

Department of Dermatology, Sapienza University of Rome, Rome, Italy.

Purpose: The aim of this study was to provide a classification of the different retinal vascular arrangements in neurofibromatosis 1 (NF1), with appropriate qualitative and quantitative information.

Methods: This study was conducted on 334 consecutive patients with NF1 and 106 sex-matched and age-matched healthy control subjects. Each patient underwent a comprehensive ophthalmological examination inclusive of near-infrared reflectance retinography by using the spectral domain Optical coherence tomography (OCT), a complete dermatological examination and 1. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313002DOI Listing
January 2019
1 Read

Classification of disease severity in retinitis pigmentosa.

Br J Ophthalmol 2019 Jan 31. Epub 2019 Jan 31.

The Wilmer Eye Institute, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA

Aim: To develop a simple and easily applicable classification of disease severity in retinitis pigmentosa (RP).

Methods: This is a retrospective cross-sectional study. Visual acuity (VA), visual field width (VF) and ellipsoid zone width (EZ) were obtained from medical records of patients with RP. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313669DOI Listing
January 2019

Ziv-aflibercept versus bevacizumab administration prior to diabetic vitrectomy: a randomised and controlled trial.

Br J Ophthalmol 2019 Jan 31. Epub 2019 Jan 31.

Instituto de la Visión-Hospital La Carlota, Montemorelos, Nuevo León, México

Purpose: To compare the effectiveness of intravitreal ziv-aflibercept (IVZ) to intravitreal bevacizumab (IVB) administered preoperatively to patients undergoing pars plana vitrectomy (PPV) for severe manifestations of proliferative diabetic retinopathy (PDR).

Design: Randomised clinical trial (RCT).

Methods: Two hundred and six patients with PDR-related complications requiring PPV were randomised into one of two treatment groups: Group A received IVZ (1. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313313DOI Listing
January 2019
1 Read

Relationship between macular vessel density and central visual field sensitivity at different glaucoma stages.

Br J Ophthalmol 2019 Jan 24. Epub 2019 Jan 24.

Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea

Aims: To evaluate the relationship between macular vessel density (mVD) and central visual field sensitivity (cVFS) at different stages of glaucoma and to compare this relationship with that between the thickness of the macular ganglion cell-inner plexiform layer (mGCIPLT) and cVFS.

Methods: The mVD and mGCIPLT were measured by optical coherence tomography angiography in 139 patients with glaucoma. The cVFS was defined as the average of 12 central points on 24-2 visual field (VF) testing. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313019DOI Listing
January 2019

Progressive cone and cone-rod dystrophies: clinical features, molecular genetics and prospects for therapy.

Br J Ophthalmol 2019 Jan 24. Epub 2019 Jan 24.

UCL Institute of Ophthalmology, University College London, London, UK

Progressive cone and cone-rod dystrophies are a clinically and genetically heterogeneous group of inherited retinal diseases characterised by cone photoreceptor degeneration, which may be followed by subsequent rod photoreceptor loss. These disorders typically present with progressive loss of central vision, colour vision disturbance and photophobia. Considerable progress has been made in elucidating the molecular genetics and genotype-phenotype correlations associated with these dystrophies, with mutations in at least 30 genes implicated in this group of disorders. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313278DOI Listing
January 2019

Five-year nationwide incidence of macular hole requiring surgery in Korea.

Br J Ophthalmol 2019 Jan 23. Epub 2019 Jan 23.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea

Background/aims: To estimate the incidence and demographics of macular hole (MH) requiring surgery in Korea.

Methods: Patients who underwent surgery for MH in Korea from 2011 to 2015 with the diagnostic code for MH and the surgical code for vitrectomy were retrospectively identified using the Korean national health claims database. The average incidence rate of MH during the 5-year study period was estimated by applying the direct method of standardisation using the 2015 census data as a reference population. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313237DOI Listing
January 2019

Early retinal neurovascular impairment in patients with diabetes without clinically detectable retinopathy.

Br J Ophthalmol 2019 Jan 23. Epub 2019 Jan 23.

Department of Ophthalmology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China

Aims: To investigate the function and the corresponding neurovascular structures in patients with diabetes without clinically detectable retinopathy. METHODS : Sixty-six patients with type 2 diabetes without retinopathy (NDR) and 62 healthy controls were recruited. The 16 and 32 Tds flicker electroretinography (ERG) was performed using a mydriasis-free, full-field flicker ERG recording device (RETeval). Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313582DOI Listing
January 2019
9 Reads

Normative pattern and determinants of outer retinal thickness in an Asian population: the Singapore Epidemiology of Eye Diseases Study.

Br J Ophthalmol 2019 Jan 18. Epub 2019 Jan 18.

Singapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore

Background/aims: To evaluate the distribution and determinants of outer retinal thickness in eyes without retinal diseases, using spectral-domain optical coherence tomography (SD-OCT).

Methods: Participants were recruited from the Singapore Epidemiology of Eye Diseases Study, a population-based study among Chinese, Malays and Indians in Singapore. A total of 5333 participants underwent SD-OCT imaging in which a 6×6 mm measurement area centred at the fovea. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3131
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http://dx.doi.org/10.1136/bjophthalmol-2018-313159DOI Listing
January 2019
8 Reads
2.976 Impact Factor

Parameters affecting postoperative success of surgery for stage 4A/4B ROP.

Br J Ophthalmol 2019 Jan 18. Epub 2019 Jan 18.

Gazi University School of Medicine, Ankara, Turkey.

Purpose: To describe the long-term anatomical and functional results of surgery for retinal detachment (RD) associated with stage 4 retinopathy of prematurity (ROP) and patient and surgery-related factors affecting postoperative success.

Design: Retrospective case series at a single tertiary referral paediatric vitreoretinal practice.

Methods: One hundred and twenty-one eyes of 82 infants (40 female/42 male) who underwent lens-sparing vitrectomy (LSV) or lensectomy with vitrectomy surgery for stage 4A and 4B ROP at Gazi University Department of Ophthalmology between 2011 and 2016 were enrolled in this study. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-312922DOI Listing
January 2019
2 Reads

Association of visual acuity with educational outcomes: a prospective cohort study.

Br J Ophthalmol 2019 Jan 18. Epub 2019 Jan 18.

Beijing Tongren Hospital, Beijing Ophthalmology Visual Science Key Lab, Beijing Institute of Ophthalmology, Capital Medical University, Beijing Tongren Eye Center, Beijing, China

Background/aim: To quantify the impact of baseline presenting visual acuity (VA), refractive error and spectacles wear on subsequent academic performance among Chinese middle school children.

Methods: A prospective, longitudinal, school-based study on grade 7 Chinese children (age, mean±SD, 12.7±0. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3132
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http://dx.doi.org/10.1136/bjophthalmol-2018-313294DOI Listing
January 2019
5 Reads

Estimation of impact of mediated inherited retinal disease on quality of life and the potential benefits of gene therapy.

Br J Ophthalmol 2019 Jan 18. Epub 2019 Jan 18.

Medicus Economics, Boston, Massachusetts, USA.

Background/aims: In rare diseases, health-related quality of life (HRQL) data can be difficult to capture. Given the ultrarare nature of -mediated inherited retinal disease (IRD), it was not feasible to recruit a patient sample and collect HRQL data prospectively. The objectives of this study were to develop health state descriptions of -mediated IRD, and to estimate associated patient utilities. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3130
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http://dx.doi.org/10.1136/bjophthalmol-2018-313089DOI Listing
January 2019
7 Reads
2.976 Impact Factor

F-fluorodeoxyglucose positron emission tomography is useful for the diagnosis of intraocular sarcoidosis in patients with a normal CT scan.

Br J Ophthalmol 2019 Jan 18. Epub 2019 Jan 18.

Service de Médecine Interne, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Lyon, France

Aim: To assess the usefulness of F-fluorodeoxyglucose positron emission tomography (F-FDG PET/CT) and the predictive factors for the diagnosis of sarcoidosis in patients with uveitis who have normal thoracic tomography.

Methods: We retrospectively reviewed 67 consecutive patients with uveitis of unknown aetiology or a suspected sarcoidosis. All patients with normal thoracic tomography underwent an F-FDG PET/CT, which was blindly reinterpreted. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313133DOI Listing
January 2019
2 Reads
2.976 Impact Factor

Classifying signs and symptoms of dry eye disease according to underlying mechanism via the Delphi method: the DIDACTIC study.

Br J Ophthalmol 2019 Jan 12. Epub 2019 Jan 12.

Department of Ophthalmology, APHP-Bichat-Claude-Bernard Hospital, Paris, France.

Background/aims: Dry eye disease (DED) is categorised by pathophysiology as aqueous deficient dry eye (ADDE), evaporative dry eye (EDE) or mixed. Treatment should be tailored to DED pathophysiology, but this is challenging to determine. This Delphi consultation aimed to categorise and weight signs and symptoms to help identify the evaporative or aqueous deficient DED origin. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3125
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http://dx.doi.org/10.1136/bjophthalmol-2018-312581DOI Listing
January 2019
5 Reads

Imaging in myopia: potential biomarkers, current challenges and future developments.

Br J Ophthalmol 2019 Jan 12. Epub 2019 Jan 12.

Singapore National Eye Centre, Singapore, Singapore.

Myopia is rapidly increasing in Asia and around the world, while it is recognised that complications from high myopia may cause significant visual impairment. Thus, imaging the myopic eye is important for the diagnosis of sight-threatening complications, monitoring of disease progression and evaluation of treatments. For example, recent advances in high-resolution imaging using optical coherence tomography may delineate early myopic macula pathology, optical coherence tomography angiography may aid early choroidal neovascularisation detection, while multimodal imaging is important for monitoring treatment response. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3128
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http://dx.doi.org/10.1136/bjophthalmol-2018-312866DOI Listing
January 2019
8 Reads
2.976 Impact Factor

Inner macular layer thickness by spectral domain optical coherence tomography in children and adults: a hospital-based study.

Br J Ophthalmol 2019 Jan 12. Epub 2019 Jan 12.

Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea

Purpose: To establish the normative ranges of macular ganglion cell layer (mGCL) and macular inner plexiform layer (mIPL) thickness using Spectralis spectral domain optical coherence tomography (SD-OCT) (Heidelberg Engineering, Inc., Heidelberg, Germany) in both Korean children and adults, and to determine factors associated with mGCL and mIPL thickness.

Methods: We conducted a retrospective, observational study of 573 healthy subjects (5-70 years old) who underwent comprehensive ophthalmic examinations in a single institution. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-312349DOI Listing
January 2019
1 Read

Effect of time to primary repair on final visual outcome after open globe injury.

Br J Ophthalmol 2019 Jan 12. Epub 2019 Jan 12.

Academic Unit of Ophthalmology, Birmingham and Midland Eye Centre, City Hospital, Birmingham, UK.

Background/aim: Historic data suggest that open globe injuries should be repaired within 12-24 hours to reduce the risk of endophthalmitis. However, endophthalmitis is uncommon when systemic antibiotic prophylaxis is given. It is not clear whether delayed primary repair impacts visual outcomes in other ways or what is the optimum time to repair. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2017-3115
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http://dx.doi.org/10.1136/bjophthalmol-2017-311559DOI Listing
January 2019
10 Reads

Dual-target, real-time PCR for the diagnosis of intraocular infections.

Br J Ophthalmol 2019 Jan 12. Epub 2019 Jan 12.

F.I. Proctor Foundation, University of California San Francisco, San Francisco, California, USA.

Background: is the most common infectious cause of posterior uveitis worldwide. Two multicopy targets (B1 and Rep529) are commonly used in PCR assays, but studies evaluating these targets in ocular fluid samples are limited. Herein, we determine the analytical characteristics of a single-reaction, internally controlled, dual-target, real-time PCR and evaluate the clinical performance of this assay in intraocular fluid samples obtained at a reference ophthalmologic centre in the USA. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313064DOI Listing
January 2019
1 Read

Utility of CLOCK CHART binocular edition for self-checking the binocular visual field in patients with glaucoma.

Br J Ophthalmol 2019 Jan 12. Epub 2019 Jan 12.

Department of Ophthalmology, Kindai University Faculty of Medicine, Osaka, Japan.

Background/aims: Car accidents caused by drivers unaware of their visual field (VF) defects under binocular vision have become an issue. We developed a simple self-check chart (CLOCK CHART binocular edition (CCBE)) to help patients with glaucoma recognise their abnormalities in the binocular VF and evaluated its usefulness.

Methods: The chart has four targets displayed at 10°, 15°, 20° and 25° eccentricities. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-312845DOI Listing
January 2019
1 Read

Queensland Microbial Keratitis Database: 2005-2015.

Br J Ophthalmol 2019 Jan 5. Epub 2019 Jan 5.

School of Optometry and Vision Science, University of New South Wales, Kensington, Queensland, Australia.

Aims: To estimate the incidence of culture-positive microbial keratitis in Queensland and analyse trends in the organisms and their sensitivities cultured from corneal scrapes, especially low-incidence organisms.

Methods: Retrospective multicentre case series of all positive corneal scrapes in Queensland, Australia between 2005 and 2015. Pathology organisations in Queensland were identified by online and local directory search and agreed to participate. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3128
Publisher Site
http://dx.doi.org/10.1136/bjophthalmol-2018-312881DOI Listing
January 2019
8 Reads

Orbital apex venous cavernous malformation with optic neuropathy: treatment with multisession gamma knife radiosurgery.

Br J Ophthalmol 2019 Jan 5. Epub 2019 Jan 5.

Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

Purpose: To evaluate the efficacy and safety of multisession gamma knife radiosurgery (GKRS) for orbital apex venous cavernous malformation causing optic neuropathy.

Methods: Retrospective cohort study in a single tertiary institution from January 2007 to December 2016 on patients who underwent multisession GKRS for orbital apex venous cavernous malformations causing optic neuropathy.

Results: There were 12 patients included in our study. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3128
Publisher Site
http://dx.doi.org/10.1136/bjophthalmol-2018-312893DOI Listing
January 2019
6 Reads

Novel gene mutation in a Chinese family with primary open-angle glaucoma.

Br J Ophthalmol 2019 Jan 5. Epub 2019 Jan 5.

Department of Ophthalmology, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, Beijing, China

Purpose: To characterise the genotype(s), phenotype(s) and age-related penetrance of glaucoma in a Chinese family with primary open-angle glaucoma (POAG).

Methods: Recruited from a Chinese family spanning four generations, 7 individuals with POAG, 1 with ocular hypertension (OHT) and 14 unaffected individuals were included in this study. Genotypic investigation included sequencing of mutation sites using a glaucoma panel in combination with high-throughput sequencing and validated using Sanger sequencing. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313069DOI Listing
January 2019
3 Reads

Ophthalmic manifestations of Gaucher disease: the most common lysosomal storage disorder.

Br J Ophthalmol 2019 Jan 5. Epub 2019 Jan 5.

Department of Ophthalmology, Norfolk & Norwich University Hospitals, Norfolk, UK

Gaucher disease (GD) results from a deficiency of glucocerebrosidase activity and the subsequent accumulation of the enzyme's metabolites, principally glucosylsphingosine and glucosylceramide. There are three principal forms: Type I, which is the most common, is usually considered non-neuronopathic. Type II, III and IIIc manifest earlier and have neurological sequelae due to markedly reduced enzyme activity. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-312846DOI Listing
January 2019
2 Reads
2.976 Impact Factor

Effects of image brightness and contrast dynamic altering stimuli (DAS) when viewing video content on ocular blood flow.

Br J Ophthalmol 2019 Jan 2. Epub 2019 Jan 2.

IRCCS - Fondazione Bietti, Rome, Italy.

Background/aim: Blood flow deficiencies of the retinal and retrobulbar circulations have been previously reported in open-angle glaucoma (OAG) and other eye diseases. Herein we investigated the effects of image brightness and contrast dynamic altering stimuli (DAS) when viewing a video content on ocular blood flow, intraocular pressure (IOP) and ocular perfusion pressure (OPP) in OAG and healthy subjects.

Methods: Thirty-five subjects, 25 with OAG (mild to moderate) and 10 healthy controls, were evaluated for blood pressure, IOP, OPP and retinal capillary blood flow before, immediately after, 30 min after and 60 min after using ReviView (a dichoptic video goggles device), which stimulates one eye with a DAS video image that is brighter and with greater contrast than the fellow eye (duration of exposure 30 min). Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-312561DOI Listing
January 2019
2 Reads

Choroidal thickness and vascular density in macular telangiectasia type 2 using swept-source optical coherence tomography.

Br J Ophthalmol 2019 Jan 2. Epub 2019 Jan 2.

Retina Service, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA

Purpose: To investigate the choroidal thickness (CT) and choroidal vascular densities (CVD) of patients with macular telangiectasia type 2 (MacTel2) and their association with other multimodal imaging features, using swept-source optical coherence tomography (SS-OCT).

Methods: Prospective, cross-sectional study. Consecutive patients with MacTel2 along with controls without any macular disease were included. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3134
Publisher Site
http://dx.doi.org/10.1136/bjophthalmol-2018-313414DOI Listing
January 2019
9 Reads

Dome-shaped macula: a potential protective factor for visual acuity after cataract surgery in patients with high myopia.

Br J Ophthalmol 2019 Jan 2. Epub 2019 Jan 2.

Department of Ophthalmology, Eye and Ear, Nose, Throat Hospital, Fudan University, Shanghai, People's Republic of China

Purpose: To evaluate whether the presence of dome-shaped macula (DSM) is a protective factor for visual acuity after cataract surgery in patients with high myopia.

Methods: Included were 891 highly myopic cataract eyes (600 patients) that were examined by optical coherence tomography (OCT) through the central fovea and underwent cataract surgery in our hospital. DSM was defined as an inward bulge >50 µm in horizontal or vertical OCT sections. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3132
Publisher Site
http://dx.doi.org/10.1136/bjophthalmol-2018-313279DOI Listing
January 2019
3 Reads

Optical coherence tomography angiography findings in cystoid macular degeneration associated with central serous chorioretinopathy.

Br J Ophthalmol 2019 Jan 2. Epub 2019 Jan 2.

Smt. Kanuri Santhamma Centre for Vitreo Retinal Diseases, L V Prasad Eye Institute, Hyderabad, India

Aim: To describe the optical coherence tomography (OCT) characteristics and to identify and analyse the incidence of choroidal neovascular (CNV) network seen on optical coherence tomography angiography (OCTA) in eyes with cystoid macular degeneration (CMD) associated with central serous chorioretinopathy (CSCR).

Methods: This was a retrospective, observational study of 29 eyes of 25 patients who were previously diagnosed as CSCR with CMD. Baseline patient characteristics, best-corrected visual acuity (BCVA), evidence of CNV network and its pattern on OCTA, distribution of CMD changes and OCT parameters, such as height of the neurosensory retinal detachment (NSD), presence of double layer sign, central macular thickness, were analysed. Read More

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http://bjo.bmj.com/lookup/doi/10.1136/bjophthalmol-2018-3130
Publisher Site
http://dx.doi.org/10.1136/bjophthalmol-2018-313048DOI Listing
January 2019
7 Reads

Circumscribed choroidal haemangioma: clinical and topographical features.

Br J Ophthalmol 2019 Jan 2. Epub 2019 Jan 2.

Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland, Ohio, USA.

Aims: To characterise the clinical and topographical features of circumscribed choroidal haemangioma (CCH) and to visualise the patterns of tumour extent in the ocular fundus.

Methods: Data on the size, shape and location of 113 CCH were converted into a database of two-dimensional retinal charts by means of computer drawing software. The extent of the tumours was visualised by merging the charts and displaying the number of overlapping tumours on colour-coded maps. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313388DOI Listing
January 2019
2 Reads