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    19973 results match your criteria British Journal of Ophthalmology[Journal]

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    Corneal shape changes of the total and posterior cornea after temporal versus nasal clear corneal incision cataract surgery.
    Br J Ophthalmol 2018 May 18. Epub 2018 May 18.
    Hayashi Eye Hospital, Fukuoka, Japan.
    Aim: To compare changes in the shape and astigmatism of the total and posterior cornea between eyes with a nasal clear corneal incision (CCI) and eyes with a temporal CCI in cataract surgery.

    Methods: The left eyes of 100 patients undergoing phacoemulsification were randomly assigned to undergo a 2.4 mm nasal (nasal CCI group) or temporal CCI (temporal CCI group). Read More

    In vivo confocal microscopy indicates an inverse relationship between the sub-basal corneal plexus and the conjunctivalisation in patients with limbal stem cell deficiency.
    Br J Ophthalmol 2018 May 18. Epub 2018 May 18.
    U.G.C. Ophthalmology, Hospital Universitario Virgen Macarena and Virgen del Rocío, Seville, Spain.
    Background/aims: Limbal stem cell deficiency (LSCD) is characterised by a marked decrease in limbal stem cells. It is classified primarily using subjective slit-lamp observations. In vivo confocal microscopy (IVCM) can non-invasively provide objective information on the condition of the limbal niche, the corneal epithelial basal cell density and the corneal sub-basal nerve plexus density (SND). Read More

    Lack of tumour pigmentation in conjunctival melanoma is associated with light iris colour and worse prognosis.
    Br J Ophthalmol 2018 May 18. Epub 2018 May 18.
    Department of Ophthalmology, Leiden University Medical Center, Leiden, The Netherlands
    Aim: To investigate whether differences in iris colour, skin colour and tumour pigmentation are related to clinical outcome in conjunctival melanoma.

    Methods: Data of 70 patients with conjunctival melanoma from the Leiden University Medical Center (Leiden, The Netherlands) and 374 patients from the Wills Eye Hospital (Philadephia, USA) were reviewed. The relation between iris colour, skin colour and tumour pigmentation versus clinical parameters and outcome was investigated using univariate and multivariate regression analyses. Read More

    Ten-year incidence of primary angle closure in elderly Chinese: the Liwan Eye Study.
    Br J Ophthalmol 2018 May 18. Epub 2018 May 18.
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China
    Purpose: To determine the 10-year incidence of all forms of primary angle closure (PAC) in phakic eyes and its risk factors in an urban Chinese population aged 50 years and older.

    Methods: Survivors of 1405 baseline participants were invited to attend the 10-year follow-up visit in the Liwan Eye Study. Participants with established baseline angle closure, including primary angle closure suspects (PACS), PAC and primary angle closure glaucoma (PACG), or those who underwent bilateral cataract surgery during the 10-year period, as well as those who did not tolerate gonioscopic examinations, were excluded from this analysis. Read More

    The impact of SIGN glaucoma guidelines on false-positive referrals from community optometrists in Central Scotland.
    Br J Ophthalmol 2018 May 18. Epub 2018 May 18.
    Department of Ophthalmology, Princess Alexandra Eye Pavilion, Edinburgh, UK.
    Background: Since the introduction of National Institute for Health and Care Excellence glaucoma guidelines 2009, the number of referrals from community optometrists to hospital eye services has increased across the UK, resulting in increase in first visit discharge rates (FVDRs).

    Aim: To assess the impact of Scottish Intercollegiate Guidelines Network (SIGN) 144 on quality of referrals from community optometrists.

    Methodology: A retrospective study of patient records who attended as new adult glaucoma referrals to clinics in Princess Alexandra Eye Pavilion, Edinburgh, and in Greater Glasgow and Clyde, was carried out across October-November 2014 (group 1) and September-October 2016 (group 2), before and after the introduction of SIGN 144. Read More

    New advances in amblyopia therapy I: binocular therapies and pharmacologic augmentation.
    Br J Ophthalmol 2018 May 18. Epub 2018 May 18.
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, USA.
    Amblyopia therapy options have traditionally been limited to penalisation of the non-amblyopic eye with either patching or pharmaceutical penalisation. Solid evidence, mostly from the Pediatric Eye Disease Investigator Group, has validated both number of hours a day of patching and days per week of atropine use. The use of glasses alone has also been established as a good first-line therapy for both anisometropic and strabismic amblyopia. Read More

    Comparison of long-term clinical evolution in highly myopic eyes with vertical oval-shaped dome with or without untreated serous retinal detachment.
    Br J Ophthalmol 2018 May 7. Epub 2018 May 7.
    Department of Ophthalmology, Virgen de la Victoria University Hospital and School of Medicine, Málaga, Spain.
    Background: To compare the long-term clinical evolution of highly myopic eyes with vertical oval-shaped dome associated with or without untreated serous retinal detachment.

    Methods: Twenty-eight patients with high myopia (40 eyes) with smooth macular elevations related to a vertical oval-shaped dome were recruited. Serous retinal detachment was investigated; 11 eyes had persistent submacular fluid (study group) and 29 eyes lacked submacular fluid (control group). Read More

    Efficacy of non-fovea-sparing ILM peeling for symptomatic myopic foveoschisis with and without macular hole.
    Br J Ophthalmol 2018 Apr 30. Epub 2018 Apr 30.
    Department of Ophthalmology, Kasr Al Ainy Hospital, Cairo University, Cairo, Egypt.
    Aim: To study anatomical and visual outcomes of pars plana vitrectomy (PPV) with non-fovea-sparing (entire) internal limiting membrane (ILM) peeling in eyes with myopic foveoschisis (MF).

    Methods: Prospective interventional case series of eyes undergoing PPV with entire ILM peeling for symptomatic MF.

    Main Outcome Measures: Preoperative spectral domain optical coherence tomography (SDOCT) epiretinal membrane, anomalous posterior vitreous detachment, vitreoschisis and postoperative changes in SD-OCT central foveal thickness (CFT), ellipsoid zone defect, foveal detachment (FD), macular hole (MH) diameter (if present) and best-corrected visual acuity (BCVA) in logarithm of the minimum angle of resolution (logMAR). Read More

    Clinical characteristics and treatment outcomes of natural killer/T-cell lymphoma involving the ocular adnexa.
    Br J Ophthalmol 2018 Apr 29. Epub 2018 Apr 29.
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
    Aims: To evaluate the clinical characteristics and treatment outcomes of natural killer/T-cell lymphoma (NKTL) involving the ocular adnexa.

    Methods: Retrospective, comparative, observational case series. A total of 350 patients with NKTL, including 27 patients with NKTL involving the ocular adnexa from 1999 to 2016. Read More

    Impact of drusen and drusenoid retinal pigment epithelium elevation size and structure on the integrity of the retinal pigment epithelium layer.
    Br J Ophthalmol 2018 Apr 29. Epub 2018 Apr 29.
    Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
    Purpose: To evaluate the impact of drusen size and structure on retinal pigment epithelium (RPE) and photoreceptor layers in eyes with early to intermediate age-related macular degeneration (AMD) using polarisation-sensitive optical coherence tomography (OCT).

    Design: Retrospective investigation of an observational cross-sectional study.

    Participants: Patients with early to intermediate AMD. Read More

    Association between HLA-B*44:03-HLA-C*07:01 haplotype and cold medicine-related Stevens-Johnson syndrome with severe ocular complications in Thailand.
    Br J Ophthalmol 2018 Apr 29. Epub 2018 Apr 29.
    Department of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Background: Polymorphisms in human leucocyte antigen (HLA) class I genes have been found to be associated with cold medicine (CM)-related Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) with severe ocular complications (SOC). Because ethnic differences in genetic predisposition to SJS/TEN among different populations have been proposed, we focused on Thai patients and investigated the association between HLA class I genotypes and CM-SJS/TEN with SOC.

    Methods: This multicentre case-control study was conducted between September 2014 and August 2017. Read More

    Quantifying vascular density and morphology using different swept-source optical coherence tomography angiographic scan patterns in diabetic retinopathy.
    Br J Ophthalmol 2018 Apr 29. Epub 2018 Apr 29.
    Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, United States
    Aims: To evaluate quantitative metrics of the retinal microvasculature in eyes with diabetic retinopathy (DR) using various en face swept-source optical coherence tomography angiography (SS-OCTA) image sizes.

    Methods: Non-segmented and segmented images were acquired using an SS-OCTA device (PLEX Elite 9000; Carl Zeiss Meditec, Dublin, California, USA). The scanning protocols included the 3×3 mm, 6×6 mm and 12×12 mm fields of view. Read More

    Retrospective cohort study exploring whether an association exists between spatial distribution of cystoid spaces in cystoid macular oedema secondary to retinitis pigmentosa and response to treatment with carbonic anhydrase inhibitors.
    Br J Ophthalmol 2018 Apr 29. Epub 2018 Apr 29.
    UCL Institute of Ophthalmology, University College London, London, UK
    Background: Carbonic anhydrase inhibitors (CAIs) are frequently used as an initial step to treat retinitis pigmentosa-associated cystoid macular oedema (RP-CMO). Interestingly, it has been postulated that CAIs might reduce outer nuclear layer (ONL) fluid more effectively than inner nuclear layer (INL) fluid due to better access to retinal pigment epithelium basolateral membrane than neurosensory retina. This retrospective cohort study explores if an association between spatial distribution of cystoid spaces in RP-CMO and CAI response exists. Read More

    Decreased expression of A20 is associated with ocular Behcet's disease (BD) but not with Vogt-Koyanagi-Harada (VKH) disease.
    Br J Ophthalmol 2018 Apr 26. Epub 2018 Apr 26.
    The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, China
    Purpose: A20 is a ubiquitously expressed and inducible cytosolic protein, which plays an important role in the negative regulation of inflammation and immunity. In this study, we investigated the role of A20 in Behcet's disease (BD) and Vogt-Koyanagi-Harada (VKH) disease.

    Methods: The levels of A20 in peripheral blood mononuclear cells (PBMCs) and dendritic cells (DCs) were detected in BD patients with active and inactive uveitis, VKH patients with active and inactive uveitis, and normal subjects, respectively, by real-time PCR. Read More

    Resting nailfold capillary blood flow in primary open-angle glaucoma.
    Br J Ophthalmol 2018 Apr 26. Epub 2018 Apr 26.
    Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts, USA
    Background/aims: An altered haemodynamic profile for various ocular posterior segment capillary beds has been documented in primary open-angle glaucoma (POAG). POAG may also involve abnormal non-ocular blood flow, and the nailfold capillaries, which are not affected by elevated intraocular pressure (IOP), are readily assessable.

    Methods: We measured resting nailfold capillary blood flow in 67 POAG and 63 control subjects using video capillaroscopy. Read More

    Global prevalence of visual impairment associated with myopic macular degeneration and temporal trends from 2000 through 2050: systematic review, meta-analysis and modelling.
    Br J Ophthalmol 2018 Apr 26. Epub 2018 Apr 26.
    Brien Holden Vision Institute, Sydney, Australia.
    Purpose: We used systematic review and meta-analysis to identify and assimilate evidence quantifying blindness and visual impairment (VI) associated with myopic macular degeneration (MMD), then derived models to predict global patterns. The models were used to estimate the global prevalence of blindness and VI associated with MMD from 2000 to 2050.

    Methods: The systematic review identified 17 papers with prevalence data for MMD VI fitting our inclusion criteria. Read More

    Prevalence of glaucoma in the Australian National Eye Health Survey.
    Br J Ophthalmol 2018 Apr 26. Epub 2018 Apr 26.
    Centre for EyeResearch Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital & Melbourne, Australia.
    Aim: To estimate the prevalence of glaucoma in Australia.

    Methods: This was a population-based study of 3098 non-Indigenous Australians (50-98 years) and 1738 Indigenous Australians (40-92 years) stratified by remoteness. Each participant underwent a standard examination that included visual field assessment, tonometry and non-mydriatic fundus photography. Read More

    Correspondence between retinotopic cortical mapping and conventional functional and morphological assessment of retinal disease.
    Br J Ophthalmol 2018 Apr 26. Epub 2018 Apr 26.
    Department of Ophthalmology, Medical University of Vienna, Vienna, Austria
    Purpose: The present study describes retinotopic mapping of the primary visual cortex using functional MRI (fMRI) in patients with retinal disease. It addresses the relationship between fMRI data and data obtained by conventional assessment including microperimetry (MP) and structural imaging.

    Methods: Initial testing involved eight patients with central retinal disease (Stargardt disease, STGD) and eight with peripheral retinal disease (retinitis pigmentosa, RP), who were examined using fMRI and MP (Nidek MP-1). Read More

    Atypical epiretinal tissue in full-thickness macular holes: pathogenic and prognostic significance.
    Br J Ophthalmol 2018 Apr 26. Epub 2018 Apr 26.
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
    Background: To elucidate the clinical characteristics of a full-thickness macular hole (FTMH) with atypical epiretinal tissue (AET), and expand the spectrum of pathogenesis of MH.

    Methods: This study involved 225 consecutive eyes of 211 patients who underwent surgery for an idiopathic FTMH. Eyes were divided into two groups according to the presence of AET. Read More

    Microaneurysm turnover is a predictor of diabetic retinopathy progression.
    Br J Ophthalmol 2018 Apr 26. Epub 2018 Apr 26.
    Association for Innovation and Biomedical Research on Light and Image (AIBILI), Coimbra, Portugal
    Aim: To analyse retinopathy phenotypes and microaneurysm (MA) turnover in mild non-proliferative diabetic retinopathy (NPDR) as predictors of progression to diabetic central-involved macular oedema (CIMO) in patients with type 2 diabetes mellitus (DM) in two different ethnic populations.

    Methods: 205 patients with type 2 DM and mild NPDR were followed in a prospective observational study for 2 years or until development of CIMO, in two centres from different regions of the world. Ophthalmological examinations, including best-corrected visual acuity (BCVA), fundus photography with RetmarkerDR analysis, and optical coherence tomography (OCT), were performed at baseline and 6 12 and 24 months. Read More

    Neuro-ophthalmological manifestations of Behçet's disease.
    Br J Ophthalmol 2018 Apr 26. Epub 2018 Apr 26.
    Internal Medicine and Clinical Immunology Department, Assistance Publique - Hôpitaux de Paris, Pitié Salpêtrière University Hospital, Pierre et Marie Curie University Paris VI, Paris, France.
    Background: The neuro-ophthalmological manifestations of Behcet's disease (BD) are rare, and data regarding their characteristics and outcome are lacking.

    Objective: To report prevalence, main characteristics and outcome of neuro-ophthalmological manifestations in BD.

    Patients And Methods: This is a retrospective monocentric study of 217 patients diagnosed with neuro-Behçet's disease (NBD), of whom 29 (13. Read More

    Changes in retinal ischaemic index correlate with recalcitrant macular oedema in retinal vein occlusion: WAVE study.
    Br J Ophthalmol 2018 Apr 26. Epub 2018 Apr 26.
    Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California, USA.
    Aim: To evaluate changes in the ischaemic index (ISI) after targeted retinal photocoagulation (TRP) and to investigate the correlation between these changes and macular oedema (ME).

    Method: Twenty-four eyes of 24 patients with retinal vein occlusion (RVO) with recurrent ME were included. Ultra-widefield fluorescein angiography (UWFFA; Optos 200Tx) was obtained at baseline and every 4 months. Read More

    Diagnostic value of ganglion cell-inner plexiform layer for early detection of ethambutol-induced optic neuropathy.
    Br J Ophthalmol 2018 Apr 26. Epub 2018 Apr 26.
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
    Aim: To evaluate the diagnostic value of macular ganglion cell-inner plexiform layer (mGCIPL) thickness versus peripapillary retinal nerve fibre layer (pRNFL) thickness for the early detection of ethambutol-induced optic neuropathy (EON).

    Methods: Twenty-eight eyes of 15 patients in the EON group and 100 eyes of 53 healthy subjects in the control group were included. All patients with EON demonstrated the onset of visual symptoms within 3 weeks. Read More

    Lacrimal gland pleomorphic adenoma and malignant epithelial tumours: clinical and imaging differences.
    Br J Ophthalmol 2018 Apr 21. Epub 2018 Apr 21.
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
    Aims: To investigate the clinical and imaging features of primary and recurrent lacrimal gland pleomorphic adenoma (LGPA), as well as lacrimal gland malignant epithelial tumours (LGMET).

    Methods: Retrospective comparative case series from September 2000 to September 2016 in a single tertiary institution. Medical records of cases with histopathologically proven primary LGPA (PLGPA), recurrent LGPA (RLGPA) and LGMET were reviewed. Read More

    Review of economic evaluations of teleophthalmology as a screening strategy for chronic eye disease in adults.
    Br J Ophthalmol 2018 Apr 21. Epub 2018 Apr 21.
    Department of Ophthalmology and Visual Sciences, University of Alberta, Edmonton, Canada
    Background/aims: Teleophthalmology is well positioned to play a key role in screening of major chronic eye diseases. Economic evaluation of cost-effectiveness of teleophthalmology, however, is lacking. This study provides a systematic review of economic studies of teleophthalmology screening for diabetic retinopathy (DR), glaucoma and macular degeneration. Read More

    Outcome of paediatric cataract surgery in Northwest Ethiopia: a retrospective case series.
    Br J Ophthalmol 2018 Apr 18. Epub 2018 Apr 18.
    Orbis International-Ethiopia, Addis Ababa, Ethiopia.
    Aim: To assess visual acuity outcomes, and factors associated with the outcome, of paediatric cataract surgery at the Child Eye Health Tertiary Facility, Gondar, Northwest Ethiopia.

    Methods: The medical records of children aged below 16 years who underwent cataract surgery between September 2010 and August 2014 were reviewed for preoperative, surgical and postoperative data.

    Results: One hundred and seventy-six eyes of 142 children (mean age 7. Read More

    Microinterventional endocapsular nucleus disassembly: novel technique and results of first-in-human randomised controlled study.
    Br J Ophthalmol 2018 Apr 18. Epub 2018 Apr 18.
    Department of Ophthalmology, University of Toronto, Toronto, Ontario, Canada.
    Aim: To assess the safety and efficacy of microinterventional endocapsular nuclear fragmentation in moderate to severe cataracts.

    Methods: This was a prospective single-masked multisurgeon interventional randomised controlled trial (ClinicalTrials.gov NCT02843594) where 101 eyes of 101 subjects with grade 3-4+ nuclear cataracts were randomised to torsional phacoemulsification alone (controls) or torsional phacoemulsification with adjunctive endocapsular nuclear fragmentation using a manual microinterventional nitinol filament loop device (miLOOP group). Read More

    Modified everting sutures: an alternative treatment for mild to moderate epiblepharon.
    Br J Ophthalmol 2018 Apr 17. Epub 2018 Apr 17.
    Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
    Purpose: To describe a modified everting suture procedure which can be used in patients with mild to moderate epiblepharon who are undergoing general anaesthesia for surgical correction of coexisting ophthalmic conditions.

    Methods: A prospective, interventional, non-comparative case series on patients with mild to moderate epiblepharon who underwent the modified everting suture procedure using permanent nylon sutures while under general anaesthesia for other ophthalmic surgery, from May 2014 to May 2016, in a single tertiary institution. Main outcome measures were correction of epiblepharon, recurrence rate and complications. Read More

    Iontophoretic delivery of dexamethasone phosphate for non-infectious, non-necrotising anterior scleritis, dose-finding clinical trial.
    Br J Ophthalmol 2018 Apr 17. Epub 2018 Apr 17.
    Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA
    Currently available treatment options for non-infectious scleritis, including non-steroidal anti-inflammatory drugs, systemic corticosteroids and immunosuppressive therapies, have both efficacy and side effect limitations. Iontophoretic delivery of corticosteroids has been demonstrated to be effective for anterior uveitis and represents a potential new approach to scleritis therapy. We hypothesised that iontophoretic delivery would provide effective and precise medication delivery to the sclera, while limiting systemic exposure and side effects. Read More

    Clinical features and visual outcomes of 111 patients with new-onset acute Vogt-Koyanagi-Harada disease treated with pulse intravenous corticosteroids.
    Br J Ophthalmol 2018 Apr 17. Epub 2018 Apr 17.
    Department of Ophthalmology, Kyorin University School of Medicine, Tokyo, Japan
    Purpose: To describe the clinical features, treatment and visual outcomes of Japanese patients with new-onset acute Vogt-Koyanagi-Harada (VKH) disease.

    Methods: Clinical records of 111 patients who presented between 1999 and 2015 to the Ocular Inflammation Service of the Kyorin Eye Center, Tokyo, were reviewed.

    Results: Of the 111 patients (68 women, 43 men), 16 had complete, 90 had incomplete and 5 had probable VKH disease. Read More

    True rotational stability of a single-piece hydrophobic intraocular lens.
    Br J Ophthalmol 2018 Apr 17. Epub 2018 Apr 17.
    Department of Ophthalmology and Optometry, Medical University of Vienna, Vienna, Austria
    Background: To evaluate rotation and its influencing factors of an aspheric one-piece hydrophobic acrylic intraocular lens (IOL) Vivinex XY1 during 6 months after operation.

    Methods: In this institutional trial, 122 eyes of 66 patients were implanted with a non-toric aspheric IOL Vivinex XY1 (Hoya Corporation, Tokyo, Japan). IOL alignment was assessed at the end of surgery, 1 hour, 1 week, 1 month and 6 months after implantation. Read More

    Depot-specific characteristics of adipose tissue-derived stromal cells in thyroid-associated orbitopathy.
    Br J Ophthalmol 2018 Apr 17. Epub 2018 Apr 17.
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Background: Thyroid-associated orbitopathy (TAO) causes inflammatory fibroproliferation of periocular connective tissues. We compared adipose tissue-derived stem/stromal cells (ADSCs) from three adipose depots of each patient with TAO on mesenchymal, myofibrogenic, adipogenic properties and associated hyaluronan (HA) synthesis.

    Methods: ADSCs were generated from periocular (eyelid, orbital) and subcutaneous (abdominal) adipose tissues of three patients with TAO. Read More

    Effect of phacoemulsification on facility of outflow.
    Br J Ophthalmol 2018 Apr 13. Epub 2018 Apr 13.
    Ophthalmology, St Thomas' Hospital, London, UK.
    Purpose: Phacoemulsification has been shown to reduce intraocular pressure (IOP). The mechanism of action is thought to be via increased trabecular outflow facility. However, studies on the relationship between phacoemulsification and outflow facility have been inconsistent. Read More

    Inter-relationship between ageing, body mass index, diabetes, systemic blood pressure and intraocular pressure in Asians: 6-year longitudinal study.
    Br J Ophthalmol 2018 Apr 9. Epub 2018 Apr 9.
    Singapore National Eye Centre, Singapore Eye Research Institute, Singapore, Singapore
    Background: To investigate the biological effect of ageing on intraocular pressure (IOP) and risk factors in a population-based cohort study of Malay and Indian adults.

    Methods: Participants aged 40-80 years were recruited for baseline and 6-year follow-up visits between 2004-2009 and 2010-2015, respectively. Blood pressure (BP) was measured with an automatic BP monitor and IOP were obtained by Goldmann applanation tonometry. Read More

    Long-term reconstruction of foveal microstructure and visual acuity after idiopathic macular hole repair: three-year follow-up study.
    Br J Ophthalmol 2018 Apr 9. Epub 2018 Apr 9.
    Department of Ophthalmology, Osaka University Graduate School of Medicine, Suita, Japan.
    Aims: To evaluate long-term reconstructive changes in foveal microstructures and their associations with visual improvement in eyes with surgically closed macular holes (MHs).

    Methods: Twenty-eight eyes of 28 patients who underwent successful idiopathic MH repair were retrospectively studied. Best-corrected visual acuity (BCVA) and spectral-domain optical coherence tomography images were examined preoperatively and 1, 3, 6, 12, 24 and 36 months postoperatively. Read More

    Association of antenatal steroid and risk of retinopathy of prematurity: a systematic review and meta-analysis.
    Br J Ophthalmol 2018 Apr 9. Epub 2018 Apr 9.
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong.
    Background: Retinopathy of prematurity (ROP) is one of the leading causes of childhood blindness. Use of antenatal steroid can reduce neonatal morbidity and mortality in preterm births, but its effect on ROP remained controversial. We aim to determine the association between antenatal steroid and risk of ROP by a systematic review and meta-analysis. Read More

    Deep anterior lamellar keratoplasty: dissection plane with viscoelastic and air can be different.
    Br J Ophthalmol 2018 Apr 3. Epub 2018 Apr 3.
    Section of Academic Ophthalmology, Division of Clinical Neuroscience, Department of Ophthalmology, University of Nottingham, Nottingham, UK.
    Aims: To investigate and define the nature of big bubbles (BB) formed by injection of viscoelastic in deep anterior lamellar keratoplasty.

    Methods: Intrastromal injections of 0.1 and 0. Read More

    Two-year follow-up of corneal cross-linking and refractive surface ablation in patients with asymmetric corneal topography.
    Br J Ophthalmol 2018 Apr 2. Epub 2018 Apr 2.
    Department of Ophthalmology and Vision Sciences, Federal University of São Paulo, São Paulo, Brazil.
    Aims: To evaluate the safety and efficacy of corneal cross-linking (CXL) followed by photorefractive keratectomy (PRK) for refractive correction in patients with bilateral asymmetric topography.

    Methods: Forty-four patients (88 eyes) were enrolled in this prospective randomised clinical trial. CXL with subsequent PRK after 6 months was performed in one eye (study group), and PRK alone was performed in contralateral eyes (control group). Read More

    Comparative analysis of large macular hole surgeries using an internal limiting membrane: insertion technique versus inverted flap technique.
    Br J Ophthalmol 2018 Apr 2. Epub 2018 Apr 2.
    Department of Ophthalmology, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea
    Background: To determine whether the internal limiting membrane (ILM) insertion technique is as effective as the inverted ILM flap technique for the initial surgical treatment of eyes with large idiopathic macular holes (MHs).

    Methods: This retrospective, non-randomised, comparative clinical study included 41 eyes with large MHs (minimum diameter >500 µm) that were treated using the ILM insertion technique or the inverted ILM flap technique. The hole closure rate, postoperative best corrected visual acuity (BCVA) and swept source optical coherence tomography findings were analysed at 6 months after surgery. Read More

    Predictability of formulae for intraocular lens power calculation according to the age of implantation in paediatric cataract.
    Br J Ophthalmol 2018 Mar 31. Epub 2018 Mar 31.
    Department of Ophthalmology, Seoul National University Hospital, Seoul, South Korea
    Aims: To analyse the predictability of diverse intraocular lens (IOL) power calculation formulae in paediatric patients with congenital cataract.

    Methods: The medical records of patients who underwent cataract surgery and posterior chamber IOL implantation (in-the-bag) for congenital cataract before 17 years of age were reviewed retrospectively. Target refractions calculated by Sanders-Retzlaff-Kraff (SRK)/II, SRK/T and Hoffer-Q formulae were compared with the actual refraction. Read More

    Evaluation of choroidal lesions with swept-source optical coherence tomography.
    Br J Ophthalmol 2018 Mar 31. Epub 2018 Mar 31.
    Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.
    Aims: The aim of our study was to image choroidal lesions with swept-source optical coherence tomography (SS-OCT) and to identify the morphological characteristics associated with optimal visualisation.

    Methods: This was a prospective, cross-sectional study. Patients with choroidal melanocytic lesions <3 mm in thickness on B-scan ultrasonography were recruited. Read More

    Acute retinal toxicity associated with a mixture of perfluorooctane and perfluorohexyloctane: failure of another indirect cytotoxicity analysis.
    Br J Ophthalmol 2018 Mar 29. Epub 2018 Mar 29.
    Instituto Universitario de Oftalmobiología Aplicada (IOBA), Eye Institute, University of Valladolid, Valladolid, Spain.
    Aims: To report new information related to acute retinal toxicity of Bio Octane Plus, a mixture of 90% perfluorooctane (PFO) and 10% perfluorohexyloctane.

    Methods: This retrospective, descriptive case series reports the occurrence of acute retinal toxicity after vitreoretinal surgery in which Bio Octane Plus (batch number 1605148) was used as an endotamponade. Cytotoxicity biocompatibility tests and chemical analyses by Fourier-transformed infrared (FTIR) spectroscopy and gas chromatography-mass spectrometry (GC-MS) of the presumed toxic product were performed. Read More

    Optical coherence tomography angiography in comparison with other multimodal imaging techniques in punctate inner choroidopathy.
    Br J Ophthalmol 2018 Mar 26. Epub 2018 Mar 26.
    Department of Ophthalmology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
    Aims: To characterise punctate lesions and choroidal neovascularisation (CNV) in eyes with punctate inner choroidopathy (PIC) using current standard multimodal imaging techniques and optical coherence tomography angiography (OCTA).

    Methods: In our prospective, single-centre study, 20 individuals with PIC underwent imaging with spectral-domain optical coherence tomography (SD-OCT), fluorescein angiography (FA), indocyanine green angiography, fundus autofluorescence, fundus colour photography and OCTA.

    Results: Thirty-two eyes of 20 patients were affected. Read More

    Surgical adhesives in ophthalmology: history and current trends.
    Br J Ophthalmol 2018 Mar 26. Epub 2018 Mar 26.
    Harvard Medical School, Boston, Massachusetts, USA.
    Tissue adhesives are gaining popularity in ophthalmology, as they could potentially reduce the complications associated with current surgical methods. An ideal tissue adhesive should have superior tensile strength, be non-toxic and anti-inflammatory, improve efficiency and be cost-effective. Both synthetic and biological glues are available. Read More

    Early OCT angiography changes of type 1 CNV in exudative AMD treated with anti-VEGF.
    Br J Ophthalmol 2018 Mar 22. Epub 2018 Mar 22.
    Department of Ophthalmology, University of Padova, Padova, Italy.
    Aims: To investigate, with optical coherence tomography angiography (OCTA), short-term changes of type 1 choroidal neovascularisation (CNV), secondary to exudative age-related macular degeneration, after anti-vascular endothelial growth factor (VEGF) treatment.

    Methods: Patients affected by type 1 CNV treated with intravitreal anti-VEGF were consecutively enrolled. All patients underwent OCTA examination before and 48 hours after anti-VEGF treatment. Read More

    Corneal transplant follow-up study II (CTFS II): a prospective clinical trial to determine the influence of HLA class II matching on corneal transplant rejection: baseline donor and recipient characteristics.
    Br J Ophthalmol 2018 Mar 22. Epub 2018 Mar 22.
    Bristol Medical School, University of Bristol, Bristol, UK.
    Purpose: To describe a study to determine the influence of HLA class II matching on allograft rejection of high-risk, full-thickness corneal transplants.

    Methods: A prospective, longitudinal, clinical trial (ISRCTN25094892) with a primary outcome measure of time to first clinically determined rejection episode. Tissue typing used DNA-based techniques. Read More

    Prevalence of the optic disc anomalies in the adult South Indian population.
    Br J Ophthalmol 2018 Mar 22. Epub 2018 Mar 22.
    Glaucoma Services, Sankara Nethralaya,Medical Research Foundation, Chennai, Tamil Nadu, India.
    Purpose: To determine the prevalence of congenitally abnormal disc (all anomalies) in an adult population in southern India.

    Methods: Subjects aged ≥40 years (n=6013) underwent a complete ophthalmic examination. Optic disc anomalies were diagnosed according to the definitions given in the article. Read More

    Baseline choroidal thickness as a short-term predictor of visual acuity improvement following antivascular endothelial growth factor therapy in branch retinal vein occlusion.
    Br J Ophthalmol 2018 Mar 22. Epub 2018 Mar 22.
    Retina Service of Wills Eye Hospital, Mid Atlantic Retina, Philadelphia, Pennsylvania, USA.
    Purpose: To evaluate the association between subfoveal choroidal thickness (SFCT) and branch retinal vein occlusion (BRVO) eyes treated with antivascular endothelial growth factor (anti-VEGF) therapy.

    Methods: Retrospective cohort study of treatment naïve BRVO eyes treated with 3 monthly anti-VEGF injections. All patients received enhanced depth imaging spectral-domain optical coherence tomography scans to determine SFCT and central macular thickness (CMT). Read More

    Full tendon medial transposition of lateral rectus with augmentation sutures in cases of complete third nerve palsy.
    Br J Ophthalmol 2018 Jun 22;102(6):715-717. Epub 2018 Mar 22.
    Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
    Management options in third nerve palsy are limited as four of the six extraocular muscles are involved. Surgery has to be tailored on a case-to-case basis. Aim of this retrospective case series is to report 1-year outcomes of a modified surgical technique entailing full tendon transposition of lateral rectus to medial rectus augmented with posterior fixation sutures in four patients with complete third nerve palsy. Read More

    What have we learned about exfoliation syndrome since its discovery by John Lindberg 100 years ago?
    Br J Ophthalmol 2018 Mar 22. Epub 2018 Mar 22.
    Department of Ophthalmology and Visual Sciences, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
    Exfoliation syndrome (XFS) is a systemic disease with significant ocular manifestations, including glaucoma and cataract. The disease impacts close to 70 million people globally and is now recognised as the most common identifiable cause of open-angle glaucoma. Since the discovery of XFS 100 years ago by Dr John G. Read More

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