143,138 results match your criteria British Journal of Mathematical and Statistical Psychology [Journal]


Healed impact trauma to a Neolithic cattle frontal bone: A posthuman perspective.

Int J Paleopathol 2018 Dec 3;24:197-200. Epub 2018 Dec 3.

School of Archaeology and Ancient History, University of Leicester, University Road, Leicester, LE1 7RH, UK. Electronic address:

Trauma associated with slaughter is identified occasionally archaeologically in the cranial remains of domesticated animals, with evidence for pole-axing occurring in Europe, especially from the Roman period onwards. The injury typically extends through the frontal bone and sinuses to penetrate the braincase, causing haemorrhage, loss of consciousness, brain damage, and death. Evidence for slaughter methods in the British Neolithic, however, is lacking. Read More

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December 2018
1 Read

Reasonable expectations of privacy in non-disclosure of familial genetic risk: What is it reasonable to expect?

Authors:
Victoria Chico

Eur J Med Genet 2018 Dec 3. Epub 2018 Dec 3.

Society and Ethics Research Group, Connecting Science, Wellcome Genome Campus, Cambridge, UK. Electronic address:

Where there is conflict between a patient's interests in non-disclosure of their genetic information to relatives and the relative's interest in knowing the information because it indicates their genetic risk, clinicians have customarily been able to protect themselves against legal action by maintaining confidence even if, professionally, they did not consider this to be the right thing to do. In ABC v St Georges Healthcare NHS Trust ([2017] EWCA Civ 336) the healthcare team recorded their concern about the wisdom of the patient's decision to withhold genetic risk information from his relative, but chose to respect what they considered to be an unwise choice. Even though professional guidance considers that clinicians have the discretion to breach confidence where they believe this to be justified, (Royal College of Physicians, Royal College of Pathologists and the British Society of Human Genetics, 2006; GMC, 2017) clinicians find it difficult to exercise this discretion in line with their convictions against the backdrop of the legal prioritisation of the duty to maintain confidence. Read More

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December 2018

[Infrapectineal plate for repair with minimal invasion of quadrilateral blade acetabular fractures: description new implant and paramedial access].

Acta Ortop Mex 2018 May-Jun;32(3):118-125

Instituto de Astronomía de la Universidad Nacional Autónoma de México.

Introduction: Quadrilateral plate fractures are the most difficult to reduce and fix. Different techniques have been developed for quadrilateral plate osteosynthesis. The objective of this work was to create an implant and a novel approach to simplify and improve acetabular fracture osteosynthesis. Read More

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December 2018

Agentic appeals increase charitable giving in an affluent sample of donors.

PLoS One 2018 6;13(12):e0208392. Epub 2018 Dec 6.

Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada.

Recent research suggests that affluent individuals adopt agentic self-concepts, striving to stand out from others and to master the environment on their own. The present study provides a road test of this idea, showing that this theorizing can be utilized to increase charitable giving among the affluent, when individuals do not realize that their behavior is being studied. In a naturalistic field experiment conducted as part of an annual fundraising campaign (N = 12,316), we randomly assigned individuals from an affluent sample to view messages focused on agency (vs. Read More

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December 2018

Effects of cold on murine brain mitochondrial function.

PLoS One 2018 6;13(12):e0208453. Epub 2018 Dec 6.

Department of Zoology, University of British Columbia, Vancouver, British Columbia, CAN.

Therapeutic hypothermia is a strategy that reduces metabolic rate and brain damage during clinically-relevant hypoxic events. Mitochondrial respiration is compromised by hypoxia, with deleterious consequences for the mammalian brain; however, little is known about the effects of reduced temperature on mitochondrial metabolism. Therefore, we examined how mitochondrial function is impacted by temperature using high resolution respirometry to assess electron transport system (ETS) function in saponin-permeabilized mouse brain at 28 and 37°C. Read More

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December 2018

A comparison of maternal and newborn health services costs in Sindh Pakistan.

PLoS One 2018 6;13(12):e0208299. Epub 2018 Dec 6.

Division of Women & Child Health, Aga Khan University, Karachi, Pakistan.

Pakistani women suffer the highest rate of maternal mortality in South Asia. A lack of comprehensive knowledge about maternal and newborn health (MNH) services costs impedes policy decisions to maximize the benefit from existing, as well as emerging, MNH interventions in Pakistan. We compared MNH service costs at different levels of care. Read More

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December 2018
2 Reads

Ventilatory responses to acute hypoxia and hypercapnia in humans with a patent foramen ovale.

J Appl Physiol (1985) 2018 Dec 6. Epub 2018 Dec 6.

School of Health and Exercise Science, University of British Columbia, Canada.

Subjects with a patent foramen ovale (PFO) have blunted ventilatory acclimatization to high altitude, compared to subjects without PFO. The blunted response observed could be due to differences in central and/or peripheral respiratory chemoreflexes. We hypothesized that compared to subjects without a PFO (PFO-), subjects with a PFO (PFO+) would have blunted ventilatory responses to acute hypoxia and hypercapnia. Read More

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December 2018
1 Read

Wound Exudate.

Authors:
Peter Bradley

Br J Community Nurs 2018 Dec;23(Sup12):S28-S32

Editor, British Journal of Healthcare Assistants.

Tina Chambers, Independent Tissue Viability Consultant. Read More

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December 2018

Dressing wounds.

Authors:
Laura Glenny

Br J Community Nurs 2018 Dec;23(Sup12):S5

Editor, British Journal of Community Nursing.

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December 2018
1 Read

Medical resource utilization of abiraterone acetate plus prednisone added to androgen deprivation therapy in metastatic castration-naive prostate cancer: Results from LATITUDE.

Cancer 2018 Dec 6. Epub 2018 Dec 6.

BC Cancer-Vancouver Centre, University of British Columbia, Vancouver, British Columbia, Canada.

Background: Abiraterone acetate plus prednisone (AA+P), when added to androgen deprivation therapy (ADT), demonstrated significant improvements in overall survival and disease progression over dual placebos added to ADT in the LATITUDE clinical trial (NCT01715285). The objective of this study was to assess event-driven medical resource utilization (MRU) of ADT plus AA+P (ADT+AA+P) versus ADT plus dual placebos (ADT+placebos) in LATITUDE.

Methods: Event-driven MRU data from LATITUDE while patients were on treatment were used for analyses. Read More

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December 2018
3 Reads

Pretest probability for patients with suspected obstructive coronary artery disease: re-evaluating Diamond-Forrester for the contemporary era and clinical implications: insights from the PROMISE trial.

Eur Heart J Cardiovasc Imaging 2018 Dec 5. Epub 2018 Dec 5.

Cardiac MR PET CT Program, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 165 Cambridge Street, Suite 400, Boston, USA.

Aims: To update pretest probabilities (PTP) for obstructive coronary artery disease (CAD ≥ 50%) across age, sex, and clinical symptom strata, using coronary computed tomography angiography (CTA) in a large contemporary population of patients with stable chest pain referred to non-invasive testing.

Methods And Results: We included patients enrolled in the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial and randomized to CTA. Exclusively level III-certified readers, blinded to demographic and clinical data, assessed the prevalence of CAD ≥ 50% in a central core lab. Read More

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December 2018
1 Read

Correction: Synthesis and application of a highly branched, mechanism-based 2-deoxy-2-fluoro-oligosaccharide inhibitor of endo-xyloglucanases.

Org Biomol Chem 2018 Dec 6. Epub 2018 Dec 6.

Michael Smith Laboratories, University of British Columbia, 2185 East Mall, Vancouver, British Columbia V6T 1Z4, Canada. and Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada and Department of Biochemistry and Molecular Biology, University of British Columbia, 2350 Health Sciences Mall, Vancouver, British Columbia V6T 1Z3, Canada.

Correction for 'Synthesis and application of a highly branched, mechanism-based 2-deoxy-2-fluoro-oligosaccharide inhibitor of endo-xyloglucanases' by Namrata Jain et al., Org. Biomol. Read More

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December 2018

Treatment-resistant and multi-therapy-resistant criteria for bipolar depression: consensus definition.

Br J Psychiatry 2018 Dec 6:1-9. Epub 2018 Dec 6.

Clinical Senior Lecturer in Mood Disorders and Consultant Psychiatrist,National Affective Disorders Service; Academic Psychiatry Training Programme Lead,Institute of Psychiatry,Psychology and Neuroscience,King's College London,South London and Maudsley NHS Foundation Trust (SLaM); andCRN South London Lead for Mental Health,Centre for Affective Disorders, Institute of Psychiatry,Psychology and Neuroscience,King's College London,South London and Maudsley NHS Foundation Trust (SLaM),UK.

Background: Most people with bipolar disorder spend a significant percentage of their lifetime experiencing either subsyndromal depressive symptoms or major depressive episodes, which contribute greatly to the high levels of disability and mortality associated with the disorder. Despite the importance of bipolar depression, there are only a small number of recognised treatment options available. Consecutive treatment failures can quickly exhaust these options leading to treatment-resistant bipolar depression (TRBD). Read More

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December 2018
4 Reads

Dual SPECT imaging of In and Ga to simultaneously determine in vivo the pharmacokinetics of different radiopharmaceuticals: a quantitative tool in pre-clinical research.

Phys Med Biol 2018 Dec 6;63(23):235029. Epub 2018 Dec 6.

Department of Radiology, University of British Columbia, Vancouver, Canada. Equal contributors.

Dual-isotope (DI) studies offer a number of advantages in pre-clinical imaging. These include: reducing study times when compared with sequential scans, reducing the number of animals required for any given study, and most importantly, producing images perfectly registered in space and time that provide simultaneous information about two distinct body functions. The ability of single photon emission computed tomography (SPECT) to measure and differentiate energies of the emitted photons makes it well suited for DI imaging. Read More

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December 2018

Temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations: FAST.

Health Technol Assess 2018 Dec;22(70):1-82

Respiratory Medicine, Nottingham NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK.

Background: Asthma exacerbations affect the quality of life of patients with asthma and have a major effect on the overall costs of asthma care. An asthma self-management plan that advises the temporary quadrupling of inhaled corticosteroid dose may prevent asthma exacerbations, but this needs to be confirmed before being adopted widely.

Objectives: To compare the clinical effectiveness and cost-effectiveness of an asthma self-management plan that advises patients to temporarily quadruple the dose of inhaled corticosteroid when asthma control starts to deteriorate with a standard self-management plan. Read More

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December 2018

Safety of Sports for Young Patients With Implantable Cardioverter-Defibrillators.

Circ Arrhythm Electrophysiol 2018 Nov;11(11):e006305

Yale University School of Medicine, New Haven, CT (J.D., C.B., L.S., F.L., R.J.L.).

Background: Despite safety concerns, many young patients with implantable cardioverter-defibrillators (ICDs) participate in sports. We undertook a prospective, multinational registry to determine the incidence of serious adverse events because of sports participation. The primary end points were death or resuscitated arrest during sports or injury during sports because of arrhythmia or shock. Read More

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November 2018

The voice of patients in system redesign: A case study of redesigning a centralized system for intake of referrals from primary care to rheumatologists for patients with suspected rheumatoid arthritis.

Health Expect 2018 Dec 5. Epub 2018 Dec 5.

Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background: The published literature demands examples of health-care systems designed with the active engagement of patients to explore the application of this complex phenomenon in practice.

Methods: This case study explored how the voice of patients was incorporated into the process of redesigning an element of the health-care system, a centralized system for intake of referrals from primary care to rheumatologists for patients with suspected rheumatoid arthritis (RA)-centralized intake. The phenomenon of patient engagement using "patient and community engagement researchers" (PaCERs) in research and the process of redesigning centralized intake were selected as the case. Read More

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December 2018
1 Read

eQTL of KCNK2 regionally influences the brain sulcal widening: evidence from 15,597 UK Biobank participants with neuroimaging data.

Brain Struct Funct 2018 Dec 5. Epub 2018 Dec 5.

UNATI, Institut Joliot, CEA, Université Paris-Saclay, Neurospin, CEA Saclay, Neurospin Bâtiment 145, 91191, Gif-sur-Yvette Cedex, France.

The grey and white matter volumes are known to reduce with age. This cortical shrinkage is visible on magnetic resonance images and is conveniently identified by the increased volume of cerebrospinal fluid in the sulci between two gyri. Here, we replicated this finding using the UK Biobank dataset and studied the genetic influence on these cortical features of aging. Read More

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December 2018
1 Read

Predictors of Mental Health Recovery in Homeless Adults with Mental Illness.

Community Ment Health J 2018 Dec 5. Epub 2018 Dec 5.

Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.

For people with mental illness, experiences of homelessness can complicate mental health recovery processes. This study used longitudinal data from a randomized controlled trial of housing first (HF) to examine predictors of recovery among homeless people with mental illness. Findings showed that health and community predictors were most strongly associated with mental health recovery. Read More

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December 2018
2 Reads

Stroke: The past, present and future.

Brain Neurosci Adv 2018 ;2:2398212818810689

Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.

Since the inception of the British Neuroscience Association, there have been major advances in our knowledge of the mechanistic basis for stroke-induced brain damage. Identification of the ischaemic cascade led to the development of hundreds of new drugs, many showing efficacy in preclinical (animal-based) studies. None of these drugs has yet translated to a successful stroke treatment, current therapy being limited to thrombolysis/thrombectomy. Read More

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January 2018

Metastatic Colorectal Cancer in the Era of Personalized Medicine: A More Tailored Approach to Systemic Therapy.

Can J Gastroenterol Hepatol 2018 5;2018:9450754. Epub 2018 Nov 5.

University of Calgary, Calgary, Canada.

Colorectal cancer is the second most common malignancy diagnosed in Canada. Despite declining incidence and mortality rates in recent years, there is still a significant number of cases that are metastatic at presentation. Fluoropyrimidine-based chemotherapy was the backbone of colorectal cancer treatment, but the addition of irinotecan and oxaliplatin to form combination regimens has significantly improved overall survival. Read More

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November 2018

Assessing community (peer) researcher's experiences with conducting spirometry and being engaged in the 'Participatory Research in Ottawa: Management and Point-of-care for Tobacco-dependence' (PROMPT) project.

Res Involv Engagem 2018 1;4:43. Epub 2018 Dec 1.

5Ottawa Hospital Research Institute, Ottawa, Canada.

Plain Summary: This article examines the overall experiences of community researchers in their involvement with the 'PROMPT' project for smoking cessation, which targeted community members who were homeless or at-risk for homelessness. More specifically, four community members, representing the study population were involved in the project as researchers. They were asked to complete surveys at both the beginning and end of each research training session to better understand their learning as it related to using a key instrument for this project, a spirometer, to measure project participants' lung function. Read More

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December 2018
1 Read

Transcripts and tumors: regulatory and metabolic programming during biotrophic phytopathogenesis.

F1000Res 2018 19;7. Epub 2018 Nov 19.

Institute for Microbiology and Genetics, Department of Molecular Microbiology and Genetics, Georg-August-University-Göttingen, Göttingen, Lower Saxony, D-37077, Germany.

Biotrophic fungal pathogens of plants must sense and adapt to the host environment to complete their life cycles. Recent transcriptome studies of the infection of maize by the biotrophic pathogen are providing molecular insights into an ordered program of changes in gene expression and the deployment of effectors as well as key features of nutrient acquisition. In particular, the transcriptome data provide a deeper appreciation of the complexity of the transcription factor network that controls the biotrophic program of invasion, proliferation, and sporulation. Read More

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November 2018
2 Reads

Navigating fragmented landscapes: Canada lynx brave poor quality habitats while traveling.

Ecol Evol 2018 Nov 26;8(22):11293-11308. Epub 2018 Oct 26.

Biology Department University of British Columbia Okanagan Kelowna British Columbia Canada.

Anthropogenic and natural habitat fragmentation inhibit movement of animals through landscapes. An important challenge for connectivity conservation is determining which conditions facilitate or limit movements, so that these areas can be prioritized for protection or restoration. We examine Canada lynx Lynx canadensis habitat connectivity in the fragmented North Cascade Mountains of Washington, as an example of a highly mobile species that is specialized both on prey and in habitat needs. Read More

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November 2018

Regional differences in winter diets of bobcats in their northern range.

Ecol Evol 2018 Nov 9;8(22):11100-11110. Epub 2018 Oct 9.

Department of Biology University of British Columbia Okanagan Kelowna British Columbia Canada.

When generalist predators have wide geographic ranges, diets may differ dramatically, largely as a result of differing prey communities. Bobcats () are widely distributed across southern North America, with their northern range edge occurring in southern Canada and in the northern US states. Within this northern range, bobcats are exposed to cold and snowy winters and a limited number of prey species, conditions that are atypical for most of the range of bobcats. Read More

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November 2018
3 Reads

Measuring agreement among experts in classifying camera images of similar species.

Ecol Evol 2018 Nov 30;8(22):11009-11021. Epub 2018 Oct 30.

Department of Biology University of British Columbia Okanagan Kelowna British Columbia Canada.

Camera trapping and solicitation of wildlife images through citizen science have become common tools in ecological research. Such studies collect many wildlife images for which correct species classification is crucial; even low misclassification rates can result in erroneous estimation of the geographic range or habitat use of a species, potentially hindering conservation or management efforts. However, some species are difficult to tell apart, making species classification challenging-but the literature on classification agreement rates among experts remains sparse. Read More

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November 2018

Responses of Morphology, Gas Exchange, Photochemical Activity of Photosystem II, and Antioxidant Balance in to Light Spectra.

Front Plant Sci 2018 21;9:1704. Epub 2018 Nov 21.

College of Forestry, Nanjing Forestry University, Nanjing, China.

Light quality is a critical factor regulating photosynthetic capacity which directly affects the final yield of plants. is a multiple function tree species and its leaves are widely used as tea production and ingredient in functional foods in China. However, the effects of varying light quality on photosynthetic process and the photoprotective mechanisms remains unexplored in-depth. Read More

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November 2018
1 Read

Cerebrovascular Function in the Large Arteries Is Maintained Following Moderate Intensity Exercise.

Front Physiol 2018 21;9:1657. Epub 2018 Nov 21.

Centre for Heart Lung and Vascular Health, School of Health and Exercise Science, University of British Columbia Okanagan, Kelowna, BC, Canada.

Exercise has been shown to induce cerebrovascular adaptations. However, the underlying temporal dynamics are poorly understood, and regional variation in the vascular response to exercise has been observed in the large cerebral arteries. Here, we sought to measure the cerebrovascular effects of a single 20-min session of moderate-intensity exercise in the one hour period immediately following exercise cessation. Read More

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November 2018

Inter-Vendor Reproducibility of Myelin Water Imaging Using a 3D Gradient and Spin Echo Sequence.

Front Neurosci 2018 21;12:854. Epub 2018 Nov 21.

Department of Medicine, The University of British Columbia, Vancouver, BC, Canada.

Myelin water imaging can be achieved using multicomponent T relaxation analysis to quantify measurement of myelin content, termed the myelin water fraction (MWF). Therefore, myelin water imaging can be a valuable tool to better understand the underlying white matter pathology in demyelinating diseases, such as multiple sclerosis. To apply myelin water imaging in multisite studies and clinical applications, it must be acquired in a clinically feasible scan time (less than 15 min) and be reproducible across sites and scanner vendors. Read More

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November 2018
4 Reads

Factors associated with choice of intensification treatment for type 2 diabetes after metformin monotherapy: a cohort study in UK primary care.

Clin Epidemiol 2018 8;10:1639-1648. Epub 2018 Nov 8.

Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK,

Purpose: To understand the patient characteristics associated with treatment choice at the first treatment intensification for type 2 diabetes.

Patients And Methods: This is a noninterventional study, using UK electronic primary care records from the Clinical Practice Research Datalink. We included adults treated with metformin monotherapy between January 2000 and July 2017. Read More

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November 2018

Rural and urban disparities in the care of Canadian patients with inflammatory bowel disease: a population-based study.

Clin Epidemiol 2018 8;10:1613-1626. Epub 2018 Nov 8.

Department of Medicine, University of Calgary, Calgary, Alberta, Canada.

Background And Aims: Canada's large geographic area and low population density pose challenges in access to specialized health care for remote and rural residents. We compared health services use, surgical rate, and specialist gastroenterologist care in rural and urban inflammatory bowel disease (IBD) patients in Canada.

Methods: We used validated algorithms that were applied to population-based health administrative data to identify all people living with the following three Canadian provinces: Alberta, Manitoba, and Ontario (ON). Read More

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November 2018

Spatiotemporal clustering of cases of Kawasaki disease and associated coronary artery aneurysms in Canada.

Sci Rep 2018 Dec 5;8(1):17682. Epub 2018 Dec 5.

Ted Rogers Centre for Heart Research, Peter Munk Cardiac Centre, University Health Network, University of Toronto, Ontario, Canada.

Detailed epidemiologic examination of the distribution of Kawasaki disease (KD) cases could help elucidate the etiology and pathogenesis of this puzzling condition. Location of residence at KD admission was obtained for patients diagnosed in Canada (excluding Quebec) between March 2004 and March 2015. We identified 4,839 patients, 164 of whom (3. Read More

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December 2018

A standardized immune phenotyping and automated data analysis platform for multicenter biomarker studies.

JCI Insight 2018 Dec 6;3(23). Epub 2018 Dec 6.

Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada.

The analysis and validation of flow cytometry-based biomarkers in clinical studies are limited by the lack of standardized protocols that are reproducible across multiple centers and suitable for use with either unfractionated blood or cryopreserved PBMCs. Here we report the development of a platform that standardizes a set of flow cytometry panels across multiple centers, with high reproducibility in blood or PBMCs from either healthy subjects or patients 100 days after hematopoietic stem cell transplantation. Inter-center comparisons of replicate samples showed low variation, with interindividual variation exceeding inter-center variation for most populations (coefficients of variability <20% and interclass correlation coefficients >0. Read More

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December 2018

Early Caffeine Administration and Neurodevelopmental Outcomes in Preterm Infants.

Pediatrics 2018 Dec 5. Epub 2018 Dec 5.

Maternal-Infant Care Research Center, Mount Sinai Hospital, Toronto, Ontario, Canada.

Background: Although caffeine use for apnea of prematurity is well studied, the long-term safety and benefit of routine early caffeine administration has not been explored. Our objective was to determine the association between early (within 2 days of birth) versus late caffeine exposure and neurodevelopmental outcomes in preterm infants.

Methods: Infants of <29 weeks' gestation born between April 2009 and September 2011 and admitted to Canadian Neonatal Network units and then assessed at Canadian Neonatal Follow-up Network centers were studied. Read More

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December 2018
2 Reads

Identifying patient-important outcomes in medication-assisted treatment for opioid use disorder patients: a systematic review protocol.

BMJ Open 2018 Dec 4;8(12):e025059. Epub 2018 Dec 4.

Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada.

Introduction: Illicit opioid use has become a national crisis in Canada, with over 65 000 people seeking treatment for opioid use disorder (OUD) in Ontario and British Columbia alone. Medication-assisted treatment (MAT) is a common treatment for OUD. There is substantial variability in treatment outcomes used to evaluate effectiveness of MAT, making it difficult to establish clinically and scientifically relevant treatment effect. Read More

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December 2018
2 Reads
2.063 Impact Factor

Household structure and its association with sexual risk behaviours and sexual health outcomes: evidence from a British probability sample survey.

BMJ Open 2018 Dec 4;8(12):e024255. Epub 2018 Dec 4.

Centre for Population Research in Sexual Health and HIV, Institute for Global Health, University College London, London, UK.

Objectives: Economic and social changes over the last 20 years have led to changes in the living situations of young people in Britain. A person's home-life context might influence their sexual behaviour, with implications for their sexual healthcare needs; we investigated this hypothesis.

Methods: Britain's third National Survey of Sexual Attitudes and Lifestyles, a probability sample survey undertaken in 2010-2012, interviewed 15 162 men and women aged 16-74 years in Britain (with 3869 aged 16-24 years). Read More

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December 2018

Non-standard treatment for uncomplicated urogenital infections: a systematic review.

BMJ Open 2018 Dec 4;8(12):e023808. Epub 2018 Dec 4.

Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Objectives: To review the literature for non-standard treatment options for uncomplicated (CT) infections in adolescents and adults.

Design: Systematic review.

Data Sources: Ovid MEDLINE/PubMed, Ovid EMBASE, Cochrane Trials & Systematic Review Databases, CINAHL Plus with Full Text, Web of Science Core Collection, Scopus, ProQuest Dissertations & Theses Global, ClinicalTrials. Read More

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December 2018

Geriatrician-led evidence-based Falls Prevention Clinic: a prospective 12-month feasibility and acceptability cohort study among older adults.

BMJ Open 2018 Dec 4;8(12):e020576. Epub 2018 Dec 4.

Center for Hip Health and Mobility, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Objective: We assessed the feasibility and acceptability of delivering a geriatrician-led evidence-based Falls Prevention Clinic to older adults with a history of falls.

Design: 12-month prospective cohort study.

Setting: Vancouver Falls Prevention Clinic, Vancouver, British Columbia, Canada (www. Read More

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December 2018

Preventing overdiagnosis and the harms of too much sport and exercise medicine.

Br J Sports Med 2018 Dec 5. Epub 2018 Dec 5.

Department of Family Practice and School of Kinesiology, Faculties of Medicine and Education, University of British Columbia, Vancouver, British Columbia, Canada.

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December 2018
1 Read

Impact of Interplaying and Compounding Factors in the Novice Nurse Journey: A Basic Qualitative Research Study.

Authors:
Shannon Dames

Can J Nurs Res 2018 Dec 5:844562118817079. Epub 2018 Dec 5.

1 Faculty of Health and Human Services, Vancouver Island University, Nanaimo, British Columbia, Canada.

Purpose: This study explores the impact of interplaying and often compounding factors and the resulting ability to thrive as a novice nurse. Novice nurse attrition rates continue to be high, compounding concerns of an impending nursing shortage. There is currently a lack of research that seeks to understand how the interplay of contextual factors impacts novice nurses' ability to manage the stressors endemic in the field. Read More

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December 2018

Chlorogenic Acid (CGA) Isomers Alleviate Interleukin 8 (IL-8) Production in Caco-2 Cells by Decreasing Phosphorylation of p38 and Increasing Cell Integrity.

Int J Mol Sci 2018 Dec 4;19(12). Epub 2018 Dec 4.

Food, Nutrition, and Health Program, Faculty of Land and Food Systems, The University of British Columbia, 2205 East Mall, Vancouver, BC V6T 1Z4, Canada.

The objective of this study was to determine the effect of six chlorogenic acid (CGA) isomers known to be present in coffee and other plant foods on modulating the inflammatory response induced by pro-inflammatory cytokines in the Caco-2 human intestinal epithelial cell line. Compared to caffeoylquinic acids (CQA), dicaffeoylquinic acids (DiCQA) had significantly stronger ( < 0.05) capacities to reduce phosphorylation of one of mitogen-activated protein kinases (MAPK) cascades, namely p38. Read More

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December 2018

Efficient Data Augmentation for Fitting Stochastic Epidemic Models to Prevalence Data.

J Comput Graph Stat 2017 9;26(4):918-929. Epub 2017 Oct 9.

Department of Statistics, University of Washington, Seattle.

Stochastic epidemic models describe the dynamics of an epidemic as a disease spreads through a population. Typically, only a fraction of cases are observed at a set of discrete times. The absence of complete information about the time evolution of an epidemic gives rise to a complicated latent variable problem in which the state space size of the epidemic grows large as the population size increases. Read More

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October 2017

Predictive connectome subnetwork extraction with anatomical and connectivity priors.

Comput Med Imaging Graph 2018 Aug 25;71:67-78. Epub 2018 Aug 25.

Medical Image Analysis Lab, Simon Fraser University, Burnaby, BC, Canada.

We present a new method to identify anatomical subnetworks of the human connectome that are optimally predictive of targeted clinical variables, developmental outcomes or disease states. Given a training set of structural or functional brain networks, derived from diffusion MRI (dMRI) or functional MRI (fMRI) scans respectively, our sparse linear regression model extracts a weighted subnetwork. By enforcing novel backbone network and connectivity based priors along with a non-negativity constraint, the discovered subnetworks are simultaneously anatomically plausible, well connected, positively weighted and reasonably sparse. Read More

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Type of pelvic disease as a risk factor for surgical site infection in women undergoing hysterectomy.

J Minim Invasive Gynecol 2018 Nov 30. Epub 2018 Nov 30.

The Ottawa Hospital Research Institute, 725 Parkdale Avenue, Ottawa ON, K1Y 4E9.

Study Objective: To quantify the relationship between type of benign pelvic disease and risk of surgical site infection (SSI) after hysterectomy DESIGN: Retrospective Cohort (Classification II-2) SETTING: Hospitals participating in the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) PATIENT(S): Women who underwent hysterectomy from 2006-2015 and recorded in NSQIP database INTERVENTION: None MEASUREMENTS AND MAIN RESULTS: SSI risk was compared for type of benign pelvic diseases, patient characteristics (age, race and selected comorbidities) and process of care variables (admission status, type of hysterectomy, and operative time). Among a total of 125,337 women who underwent hysterectomy, 2.48% developed SSI. Read More

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November 2018

Novel Percutaneous Treatment of Cerebral Malperfusion Prior to Surgery for Acute Type A Dissection.

Ann Thorac Surg 2018 Nov 30. Epub 2018 Nov 30.

University of British Columbia. Electronic address:

We present the first known application of pre-operative percutaneous management of cerebral malperfusion in a patient with acute near-total occlusion of the right common carotid artery with left hemiplegia complicating an acute Stanford Type A aortic (Type A) dissection. Read More

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November 2018

The Association of Coloproctology of Great Britain and Ireland consensus guidelines in surgery for inflammatory bowel disease.

Colorectal Dis 2018 Dec;20 Suppl 8:3-117

Western General Hospital, Edinburgh, UK.

Aim: There is a requirement of an expansive and up to date review of surgical management of inflammatory bowel disease (IBD) that can dovetail with the medical guidelines produced by the British Society of Gastroenterology.

Methods: Surgeons who are members of the ACPGBI with a recognised interest in IBD were invited to contribute various sections of the guidelines. They were directed to produce a procedure based document using literature searches that were systematic, comprehensible, transparent and reproducible. Read More

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December 2018

Reproductive heat tolerance in a Mojave Desert annual plant, Trianthema portulacastrum.

Am J Bot 2018 Dec 3. Epub 2018 Dec 3.

Department of Ecology and Evolutionary Biology, University of Toronto, 25 Willcocks Street, Toronto, ON, M5S 3B2, Canada.

Premise Of The Study: Reproduction in many crop species is impaired above 30° to 35°C; however, the sensitivity of reproduction in the natural flora remains uncertain. Studies focusing on the effect of high temperature on plant reproduction in wild species are necessary to improve our understanding of how rising global temperatures will impact global plant reproductive success and may ultimately inform models of plant distribution in the future. Additionally, these studies may highlight candidates for thermotolerance that could be further explored for crop improvement. Read More

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December 2018