162,832 results match your criteria British Journal of Diabetes and Vascular Disease [Journal]


Normative references and clinical correlates of fetal umbilical artery Doppler indices in southwestern Nigeria.

Int J Gynaecol Obstet 2020 Jul 3. Epub 2020 Jul 3.

Department of Radiology, Lagos State University Teaching Hospital, Lagos, Nigeria.

Objective: To derive normative references for umbilical artery (UA) Doppler indices, including pulsatility index (PI), resistance index (RI), and systolic/diastolic (SD) ratio, for singleton pregnancies in Ile-Ife, Nigeria, and compare them with reference values from other populations.

Methods: A longitudinal study involving 415 women with a singleton fetus at 26-40 gestational weeks attending Obafemi Awolowo University Hospital, Ile-Ife, between July 2015 and March 2019. Fetal UA PI, RI, and SD ratio were measured every 4 weeks until delivery. Read More

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http://dx.doi.org/10.1002/ijgo.13294DOI Listing

Isolated limb perfusion for soft tissue sarcoma: Current practices and future directions. A survey of experts and a review of literature.

Cancer Treat Rev 2020 Jun 19;88:102058. Epub 2020 Jun 19.

Sarcoma Unit, Department of Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy.

Soft tissue sarcomas constitute 1% of adult malignant tumors. They are a heterogeneous group of more than 50 different histologic types. Isolated limb perfusion is an established treatment strategy for locally advanced sarcomas. Read More

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http://dx.doi.org/10.1016/j.ctrv.2020.102058DOI Listing

Investigation of spectroscopic and proteomic alterations underlying prostate carcinogenesis.

J Proteomics 2020 Jun 30:103888. Epub 2020 Jun 30.

iBiMED - Institute of Biomedicine, Department of Medical Sciences, University of Aveiro, Aveiro, Portugal. Electronic address:

Prostate cancer (PCa) treatment remains challenging, especially in advanced stages, where the lack of sensitivity and specificity of available biomarkers makes it difficult to establish an accurate prognosis. Therefore, it is imperative to study PCa biology to identify key molecules that can improve PCa management. In this study, eight prostate tumor tissues and paired normal tissues were analyzed using two approaches-Fourier-transform infrared (FT-IR) spectroscopy for spectroscopic profiling of biomolecules and antibody microarray for signaling proteins-with the main goal of identifying metabolic and proteomic changes that enable the distinction between normal and tumor conditions. Read More

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http://dx.doi.org/10.1016/j.jprot.2020.103888DOI Listing

Is it always possible to complete a systematic review in 2 weeks? Further thoughts and considerations.

J Clin Epidemiol 2020 Jun 30. Epub 2020 Jun 30.

Pharmalytics Group, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1016/j.jclinepi.2020.06.034DOI Listing

External Validation Demonstrated The Ottawa SAH Prediction Models Can Identify pSAH Using Health Administrative Data.

J Clin Epidemiol 2020 Jun 30. Epub 2020 Jun 30.

Department of Medicine (Clinical Epidemiology), uOttawa; Clinical Epidemiology Program, Ottawa Hospital Research Institute; ICES-uOttawa, Administrative Services, 1053 Carling Ave Building, 1st Floor, Ottawa, ON K1Y 4E9.

Objective: To externally validate 3 pSAH identification models.

Study Design And Setting: We evaluated 3 models that identify pSAH using recursive partitioning (A), logistic regression (B), and a prevalence adjusted logistic regression(C), respectively. Blinded chart review and/or linkage to existing registries determined pSAH status. Read More

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http://dx.doi.org/10.1016/j.jclinepi.2020.06.024DOI Listing

Wave-like Patterns of Plant Phenology Determine Ungulate Movement Tactics.

Curr Biol 2020 Jun 26. Epub 2020 Jun 26.

US Geological Survey, Wyoming Cooperative Fish and Wildlife Research Unit, Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071, USA.

Animals exhibit a diversity of movement tactics [1]. Tracking resources that change across space and time is predicted to be a fundamental driver of animal movement [2]. For example, some migratory ungulates (i. Read More

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http://dx.doi.org/10.1016/j.cub.2020.06.032DOI Listing

Continent-wide Shifts in Song Dialects of White-Throated Sparrows.

Curr Biol 2020 Jun 30. Epub 2020 Jun 30.

Department of Biology, Wilfrid Laurier University, Waterloo, ON N2L 3C5, Canada.

Hypotheses on regional song variation ("dialects") assume that dialects remain stable within regions, are distinct between regions, and persist within populations over extensive periods [1-3]. Theories to explain dialects focus on mechanisms that promote persistence of regional song variants despite gene flow between regions [4-6], such as juveniles settling in non-natal populations retaining only those songs from their repertoires that match neighbors [7, 8]. It would be considered atypical for a novel song variant to invade and replace the established regional variant. Read More

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http://dx.doi.org/10.1016/j.cub.2020.05.084DOI Listing

SLC44A2 - A novel therapeutic target for venous thrombosis?

J Thromb Haemost 2020 Jul;18(7):1556-1558

Department of Immunology & Inflammation, Imperial College London, London, UK.

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http://dx.doi.org/10.1111/jth.14834DOI Listing

Making Sense of the Hands and Mouth: The Role of "Secondary" Cues to Meaning in British Sign Language and English.

Cogn Sci 2020 Jul;44(7):e12868

Division of Psychology and Language Sciences, University College London.

Successful face-to-face communication involves multiple channels, notably hand gestures in addition to speech for spoken language, and mouth patterns in addition to manual signs for sign language. In four experiments, we assess the extent to which comprehenders of British Sign Language (BSL) and English rely, respectively, on cues from the hands and the mouth in accessing meaning. We created congruent and incongruent combinations of BSL manual signs and mouthings and English speech and gesture by video manipulation and asked participants to carry out a picture-matching task. Read More

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http://dx.doi.org/10.1111/cogs.12868DOI Listing

Monte Carlo simulation of uncertainty to identify barriers to optimizing blood pressure control.

J Hypertens 2020 Jun 29. Epub 2020 Jun 29.

King's College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences.

Objectives: To assess the impact of variable drug response and measurement error on SBP control.

Methods: We simulated a treat-to-target strategy for populations with different pretreatment SBP, whereby medications were added sequentially until measured SBP (mSBP) less than 140 mmHg. Monte Carlo simulations determined variability of both drug response (drugeff ± σdrug; 10 ± 5 mmHg base case) and measurement error (σmeas; 10 mmHg base case) of true SBP (tSBP). Read More

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http://dx.doi.org/10.1097/HJH.0000000000002546DOI Listing

The role of FLIR ONE ® thermography in complex regional pain syndrome: A case series.

Am J Phys Med Rehabil 2020 Jul 1. Epub 2020 Jul 1.

University of British Columbia, Division of Physical Medicine and Rehabilitation, Department of Medicine, Victoria, BC, Canada.

Complex regional pain syndrome (CRPS) remains a debated syndrome characterized by symptoms and signs, including pain, sensory disturbances, thermal asymmetry, edema, and motor impairments. Thermography is a tool that assesses skin surface temperature distribution. Current literature appears to support the role of thermography for diagnostic purposes, however its role in monitoring the response to treatment in CRPS is unclear. Read More

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http://dx.doi.org/10.1097/PHM.0000000000001522DOI Listing

Professional Identity Formation: A Role for Patients as Mentors.

Acad Med 2020 Jun 30. Epub 2020 Jun 30.

C.C. Kline is research coordinator, Patient and Community Partnership for Education, University of British Columbia, Vancouver, British Columbia, Canada; ORCID: https://orcid.org/0000-0003-2254-0721. S. Park is a family medicine resident, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; ORCID: https://orcid.org/0000-0002-0088-8527. W.J. Godolphin is professor emeritus, Department of Pathology and Laboratory Medicine, Faculty of Medicine, and codirector, Patient and Community Partnership for Education, University of British Columbia, Vancouver, British Columbia, Canada; ORCID: https://orcid.org/0000-0003-0113-1339. A. Towle is associate professor, Department of Medicine, Faculty of Medicine, and co-director, Patient and Community Partnership for Education, University of British Columbia, Vancouver, British Columbia, Canada; ORCID: https://orcid.org/0000-0002-7164-0959.

Purpose: Medical education should foster professional identity formation, but there is much to be learned about how to support learners to develop their professional identity. This study examined the role that patients can play in supporting professional identity development during the University of British Columbia Interprofessional Health Mentors Program (HMP), a longitudinal preclinical elective in which patients, or their caregivers, act as mentors and educate students about their lived experience of a chronic condition or disability.

Method: The authors interviewed 18 medical residents in 2016, 3 to 4 years after they completed the HMP. Read More

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http://dx.doi.org/10.1097/ACM.0000000000003561DOI Listing

Exploring the Contributions of Combined Model Regional Medical Education Campuses to the Physician Workforce.

Acad Med 2020 Jun 30. Epub 2020 Jun 30.

J. Bates was professor emerita, Department of Family Practice, University of British Columbia, Vancouver, British Columbia, Canada, at the time this work was done. ORCID: http://orcid.org/0000-0001-6940-2946. P. Grand'Maison is professor, Departments of Family Medicine and Emergency Medicine, Université de Sherbrooke, Sherbrooke, Quebec, Canada. S.R. Banner was CEO, Canadian Resident Matching Service, from 1986-2016, and is Director of Admissions for Canada, St. George's Medical School, Ottawa, Ontario, Canada. C.Y. Lovato is professor, School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. K.W. Eva is professor and director of education research and scholarship, Department of Medicine, and associate director and senior scientist, Centre for Health Education Scholarship, University of British Columbia, Vancouver, British Columbia, Canada. ORCID: http://orcid.org/0000-0002-8672-2500.

Purpose: Physician shortages and maldistribution, particularly within family medicine, have led many medical schools worldwide to create regional medical campuses (RMCs) for clerkship training. However, Canadian medical schools have developed a number of RMCs in which all years of training (i.e. Read More

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http://dx.doi.org/10.1097/ACM.0000000000003560DOI Listing

Effects of a 12-Week Multifaceted Wearable-Based Program for People With Knee Osteoarthritis: Randomized Controlled Trial.

JMIR Mhealth Uhealth 2020 Jul 3;8(7):e19116. Epub 2020 Jul 3.

Arthritis Research Canada, Richmond, BC, Canada.

Background: Current guidelines emphasize an active lifestyle in the management of knee osteoarthritis (OA), but up to 90% of patients with OA are inactive. In a previous study, we demonstrated that an 8-week physiotherapist (PT)-led counseling intervention, with the use of a Fitbit, improved step count and quality of life in patients with knee OA, compared with a control.

Objective: This study aimed to examine the effect of a 12-week, multifaceted wearable-based program on physical activity and patient outcomes in patients with knee OA. Read More

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http://dx.doi.org/10.2196/19116DOI Listing

CAEP Joint Position Statement - Management of devastating brain injuries in the emergency department: Enhancing neuroprognostication and maintaining the opportunity for organ and tissue donation.

CJEM 2020 Jun 19:1-3. Epub 2020 Jun 19.

Division of Critical Care, Montreal Children's Hospital, McGill University Health Centre, Montreal, QC.

The primary purpose of this statement is to improve neuroprognostication after devastating brain injury (DBI), with a secondary benefit of potential organ and tissue donation. Read More

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http://dx.doi.org/10.1017/cem.2020.357DOI Listing

Dilated Cardiomyopathy Mutations in Thin Filament Regulatory Proteins Reduce Contractility, Suppress Systolic Ca & Activate NFAT & AKT Signalling.

Am J Physiol Heart Circ Physiol 2020 Jul 3. Epub 2020 Jul 3.

Radcliffe Department of Medicine (Division of Cardiovascular Medicine), University of Oxford, United Kingdom.

Dilated cardiomyopathy (DCM) is clinically characterised by dilated ventricular cavities and reduced ejection fraction, leading to heart failure and increased thromboembolic risk. Mutations in thin filament regulatory proteins can cause DCM and have been shown in vitro to reduce contractility and myofilament Ca-affinity. In this work we have studied the functional consequences of mutations in cardiac troponin T (R131W), cardiac troponin I (K36Q) and α-tropomyosin (E40K) using adenovirally transduced isolated guinea pig left ventricular cardiomyocytes. Read More

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http://dx.doi.org/10.1152/ajpheart.00272.2020DOI Listing

Alterations in resting cerebrovasscular regulation do not affect reactivity to hypoxia, hyperoxia, or neurovascular coupling following a SCUBA dive.

Exp Physiol 2020 Jul 3. Epub 2020 Jul 3.

Centre for Heart, Lung and Vascular Health, School of Health and Exercise Sciences, University of British Columbia, Okanagan, Kelowna, Canada.

New Findings: What is the central question of this study? To characterize cerebral blood flow (CBF) regulation following a single SCUBA dive to a depth of 18 m sea water with a 47-minute bottom time. What is the main finding and its importance? Acute alterations in CBF regulation at rest, including; extra-cranial vasodilation, reductions in shear patterns, and elevations in intra-cranial blood velocity were observed at rest following a single SCUBA dive. These subtle changes in CBF regulation did not translate into any functional changes in cerebrovascular reactivity to hypoxia or hyperoxia, or neurovascular coupling following a single SCUBA dive. Read More

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http://dx.doi.org/10.1113/EP088746DOI Listing

Disease Activity in Inflammatory Bowel Disease Is Associated With Arterial Vascular Disease.

Inflamm Bowel Dis 2020 Jul 3. Epub 2020 Jul 3.

Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK.

Background And Aims: There is evidence that several inflammatory diseases are associated with increased cardiovascular risk. Whether this is true for inflammatory bowel diseases remains controversial. We aimed to assess this risk, corrected for the effects of conventional vascular risk factors and IBD disease activity. Read More

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http://dx.doi.org/10.1093/ibd/izaa156DOI Listing

Little Doubt That CBT Works for Pediatric OCD.

J Am Acad Child Adolesc Psychiatry 2020 Jul 25;59(7):785-787. Epub 2020 Jun 25.

Baylor College of Medicine, Houston, Texas.

We write with great concern in response to the recent systematic review and meta-analysis of cognitive-behavioral therapy (CBT) in pediatric obsessive-compulsive disorder (OCD) by Uhre et al. Although the authors' results consistently support the clinical efficacy of CBT for pediatric OCD, we expect that, much like ourselves, readers will be confused by the discordant and inappropriate conclusions that they put forward. These conclusions stem from the authors' application and interpretation of their particular qualitative methods, which could lead important stakeholders (eg, parents, patients, clinicians, and payers) to wrongly discount clear evidence for what is known to be the best evidence-based therapy for pediatric OCD. Read More

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http://dx.doi.org/10.1016/j.jaac.2020.01.026DOI Listing

Optimal cut-off points for waist circumference in the definition of metabolic syndrome in Chile.

Public Health Nutr 2020 Jul 3:1-6. Epub 2020 Jul 3.

Department of European and Mediterranean Cultures: Architecture, Environment and Cultural Heritage (DICEM), University of Basilicata, Matera, Italy.

Objective: To identify sex-specific cut-off points for waist circumference (WC) in the definition of metabolic syndrome (MetS) for the Chilean adult population.

Design: MetS was defined as the presence of at least two out of four of the following criteria: TAG ≥1·7 mmol/l; HDL-cholesterol: <1·3 mmol/l in women and <1·0 mmol/l in men; systolic blood pressure ≥130 mmHg and/or diastolic blood pressure ≥85 mmHg; and fasting glucose ≥ 5·6 mmol/l or current treatment for diabetes. The receiver operating characteristics curve and the AUC were computed to derive the specificity and sensitivity using bootstrapping (10 000 iterations restricted to have at least between 40 and 60 % of the original population). Read More

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http://dx.doi.org/10.1017/S1368980020001469DOI Listing

LncRNA promotes taxane resistance in castration-resistant prostate cancer via a BCL2A1-dependent mechanism.

Epigenomics 2020 Jul 3. Epub 2020 Jul 3.

School of Life, Health & Chemical Sciences, The Open University, Walton Hall, Milton Keynes, Buckinghamshire, MK7 6AA, UK.

Castration-resistant prostate cancer (CRPC) is an incurable malignancy. Long noncoding RNAs (lncRNAs) play key roles in drug resistance. LncRNA role in cabazitaxel resistance (i. Read More

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http://dx.doi.org/10.2217/epi-2019-0316DOI Listing

Effects of forced taxonomic transitions on metabolic composition and function in microbial microcosms.

Environ Microbiol Rep 2020 Jul 2. Epub 2020 Jul 2.

Biodiversity Research Centre, University of British Columbia, Canada.

Surveys of microbial systems indicate that in many situations taxonomy and function may constitute largely independent ("decoupled") axes of variation. However, this decoupling is rarely explicitly tested experimentally, partly because it is hard to directly induce taxonomic variation without affecting functional composition. Here we experimentally evaluate this paradigm using microcosms resembling lake sediments and subjected to two different levels of salinity (0 and 19) and otherwise similar environmental conditions. Read More

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http://dx.doi.org/10.1111/1758-2229.12866DOI Listing

Sodium glucose co-transporter-2 inhibitors in heart failure: beyond glycaemic control. The Position Paper of the Heart Failure Association of the European Society of Cardiology.

Eur J Heart Fail 2020 Jul 2. Epub 2020 Jul 2.

Department of Medical Sciences, IRCCS San Raffaele Pisana, Rome, Italy.

Heart failure (HF) is common and associated with a poor prognosis, despite advances in treatment. Over the last decade cardiovascular outcome trials with sodium-glucose co-transporter 2 (SGLT-2) inhibitors in patients with type 2 diabetes mellitus (T2DM) have demonstrated beneficial effects for three SGLT-2) inhibitors (empagliflozin, canagliflozin and dapagliflozin) in reducing hospitalisations for HF. More recently, dapagliflozin reduced the risk of worsening HF or death from CV causes in patients with chronic HF with reduced left ventricular ejection fraction, with or without T2DM. Read More

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http://dx.doi.org/10.1002/ejhf.1954DOI Listing

Gay Voice: Stable Marker of Sexual Orientation or Flexible Communication Device?

Arch Sex Behav 2020 Jul 3. Epub 2020 Jul 3.

Dipartimento di Psicologia dello Sviluppo e della Socializzazione, University of Padova, Via Venezia 8, 35122, Padua, Italy.

Listeners rely on vocal features when guessing others' sexual orientation. What is less clear is whether speakers modulate their voice to emphasize or to conceal their sexual orientation. We hypothesized that gay individuals adapt their voices to the social context, either emphasizing or disguising their sexual orientation. Read More

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http://dx.doi.org/10.1007/s10508-020-01771-2DOI Listing

The risk and trend of pulmonary embolism and deep vein thrombosis in rheumatoid arthritis: a general population-based study.

Rheumatology (Oxford) 2020 Jul 2. Epub 2020 Jul 2.

Arthritis Research Canada, Richmond.

Objectives: To estimate the overall risk of venous thromboembolism (VTE), pulmonary embolism (PE) and deep vein thrombosis (DVT) among patients newly diagnosed with RA compared with the general population without RA; and to estimate the risk trends of VTE, PE and DVT after RA diagnosis up to 5 years compared with the general population.

Methods: Using previously validated RA case definition, we conducted a matched cohort study using the population-based administrative health database from the province of British Columbia, Canada. We calculated incidence rates (IRs) and fully adjusted hazard ratios (HRs) for the risk of VTE, DVT and PE after RA index date. Read More

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http://dx.doi.org/10.1093/rheumatology/keaa262DOI Listing

Do athletes play by different rules? Obstructive coronary artery disease in asymptomatic competitive Masters athletes: a case series.

Eur Heart J Case Rep 2020 Jun 26;4(3):1-5. Epub 2020 Mar 26.

SportsCardiologyBC, University of British Columbia, 2211 Wesbrook Mall, Vancouver, British Columbia V6K 2V8, Canada.

Background: Both the age and number of endurance Masters athletes is increasing; this coincides with increasing cardiovascular risk. The vast majority of sports-related sudden cardiac deaths (SCDs) occur among athletes >35 years of age. Coronary artery disease (CAD) is the most common cause of SCD amongst Masters athletes. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319857PMC

Chest pain without obstructive coronary artery disease: a case series.

Eur Heart J Case Rep 2020 Jun 24;4(3):1-6. Epub 2020 Apr 24.

West of Scotland Heart and Lung Centre, Golden Jubilee National Hospital, Agamemnon Street, Glasgow G81 4DY, UK.

Background: Ischaemic heart disease is a leading cause of mortality in women. Even in those without obstructive coronary artery disease (CAD), women with angina continue to have increased mortality. There are gender differences in prevalence of different pathophysiologies, including functional disorders such as microvascular and vasospastic angina. Read More

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http://dx.doi.org/10.1093/ehjcr/ytaa060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319819PMC

Increasing the power of randomized trials comparing different treatment durations.

Contemp Clin Trials Commun 2020 Sep 10;19:100588. Epub 2020 Jun 10.

School of Population and Public Health, University of British Columbia, 2206 East Mall, Vancouver, BC, V6T 1Z3, Canada.

When the optimal treatment duration is uncertain, a randomized trial may allocate patients to receive active treatment for different durations. We use an example where patients receive treatment for 0, 24, or 52 weeks. In this trial, patients in the 24-weeks and 52-weeks arms receive the same treatment during the first 24 weeks. Read More

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http://dx.doi.org/10.1016/j.conctc.2020.100588DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322686PMC
September 2020

An automated clinical mass spectrometric method for identification and quantification of variant and wild-type amyloid-β 1-40 and 1-42 peptides in CSF.

Alzheimers Dement (Amst) 2020 30;12(1):e12036. Epub 2020 Jun 30.

Department of Pathology and Laboratory Medicine Providence Health Care Vancouver British Columbia Canada.

Introduction: We developed an automated liquid chromatography-tandem mass spectrometry high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) method for multiplex quantification of wild-type (wt) amyloid β (Aβ) peptides 1-40 (Aβ40) and 1-42 (Aβ42) and detection of variant Aβ peptides in cerebrospinal fluid.

Methods: The multiplex Aβ HPLC-MS/MS assay was validated in a clinically accredited laboratory following regulatory guidelines, with Aβ42 calibration assigned to the ERM/IFCC certified reference material; sequence variants were additionally multiplexed into the method.

Results: Sample preparation was fully automated on a liquid handler. Read More

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http://dx.doi.org/10.1002/dad2.12036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327131PMC

Influences for Gender Disparity in Academic Family Medicine in North American Medical Schools.

Cureus 2020 May 30;12(5):e8368. Epub 2020 May 30.

Radiology, Vancouver General Hospital, Vancouver, CAN.

Background Women physicians continue to comprise the minority of leadership roles in Academic Family Medicine (AFM) faculty across North American medical schools. Our study quantified the current state of gender disparity by analyzing academic position, leadership ranking, and research productivity. Methods We generated a database for 6,746 AFM faculty members. Read More

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http://dx.doi.org/10.7759/cureus.8368DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326302PMC

Recognition of Advanced Practice Pharmacists in Australia and Beyond: Considerations for Canadian Practitioners.

Can J Hosp Pharm 2020 May-Jun;73(3):225-231. Epub 2020 Jun 1.

, BPharm, MClinPharm, AdvPracPharm, is with the Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308161PMC

Assessing the Need for Proton Pump Inhibitors for Patients Using Long-Term Nonsteroidal Anti-inflammatory Drugs without a History of Ulcers.

Can J Hosp Pharm 2020 May-Jun;73(3):216-217. Epub 2020 Jun 1.

Researcher and Educator, Therapeutics Initiative, Faculty of Medicine, The University of British Columbia, Medication Use Evaluation Pharmacist, Lower Mainland Pharmacy Services, Vancouver, British Columbia.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308151PMC

Vasopressin for Septic Shock in a Medical-Surgical Intensive Care Unit.

Can J Hosp Pharm 2020 May-Jun;73(3):209-215. Epub 2020 Jun 1.

, BSc, BSc(Pharm), ACPR, is with the Department of Pharmacy Services and the Department of Emergency Medicine, Surrey Memorial Hospital, Surrey, British Columbia.

Background: Critically ill patients often need vasopressors to treat hypotension related to septic shock and to maintain adequate systemic perfusion. Although the 2017 guidelines of the Surviving Sepsis Campaign recommend norepinephrine as first-line therapy, they also state that vasopressin may be considered as an adjunctive agent for patients with refractory shock. Limited evidence is available for directing optimal administration of vasopressin. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308152PMC

Point Prevalence Survey of Benzodiazepine and Sedative-Hypnotic Drug Use in Hospitalized Adult Patients.

Can J Hosp Pharm 2020 May-Jun;73(3):193-201. Epub 2020 Jun 1.

, BScPhm, MSc, PharmD, FCSHP, is with the Nova Scotia Health Authority and the College of Pharmacy, Dalhousie University, Halifax, Nova Scotia.

Background: Benzodiazepines and sedative-hypnotic drugs (BZD/SHDs), such as zopiclone and the antidepressant trazodone, pose risks such as falls, fractures, and confusion, especially for older adults. Use of these drugs in the acute care setting is poorly understood.

Objectives: To determine the point prevalence and characteristics of use of BZD/SHDs in hospitals in Nova Scotia, Canada. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308153PMC

Pharmacist- or Nurse Practitioner-Led Assessment and Titration of Sacubitril/Valsartan in a Heart Failure Clinic: A Cohort Study.

Can J Hosp Pharm 2020 May-Jun;73(3):186-192. Epub 2020 Jun 1.

, BSc(Pharm), ACPR, is Clinical Pharmacist with the Surrey Memorial Hospital, Lower Mainland Pharmacy Services, Surrey, British Columbia.

Background: Sacubitril/valsartan is a first-in-class angiotensin receptor-neprilysin inhibitor indicated in the management of heart failure with reduced ejection fraction, based on the results of the PARADIGM-HF trial. Practice-based studies are needed to validate its effect in real-world settings. Clinical pharmacists are ideally situated to assess and titrate sacubitril/valsartan. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308157PMC

Barriers to and Enablers of Implementation of High-Value Interventions by Renal Pharmacists: A Qualitative Study Informed by the Theoretical Domains Framework.

Can J Hosp Pharm 2020 May-Jun;73(3):177-185. Epub 2020 Jun 1.

, BSc(Pharm), ACPR, PharmD, is a Clinical Pharmacy Specialist - Nephrology, Kelowna General Hospital, Kelowna, British Columbia.

Background: Previous studies have shown that patients with chronic kidney disease who are followed by a renal clinical pharmacist have improved clinical outcomes. In 2016, a consensus list of quality indicator drug therapy problems (QI-DTPs) was developed by renal clinical pharmacists to help prioritize which renal patients should receive interventions. Before QI-DTP interventions can be implemented in clinical practice, barriers to and enablers of their use need to be identified, to allow development of strategies to overcome the barriers and apply the enablers. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308154PMC

Prolonged deployed hospital care in the management of military eye injuries.

Eye (Lond) 2020 Jul 2. Epub 2020 Jul 2.

Department of Ophthalmology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Background/objectives: Prolonged hospital care is described as deployed medical care, applied beyond doctrinal planning timelines and military medical planning envisages that in future conflicts, patients will have to be managed for up to 5 days without evacuation to their home country. We aimed to investigate the effect of prolonged hospital care on visual outcomes in the management of open and closed globe injures.

Methods: We conducted a retrospective cohort study in the setting of British military operations in Afghanistan. Read More

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http://dx.doi.org/10.1038/s41433-020-1070-2DOI Listing

The influence of postural threat on strategy selection in a stepping-down paradigm.

Sci Rep 2020 Jul 2;10(1):10815. Epub 2020 Jul 2.

Department of Human Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands.

To walk safely in their environment, people need to select adequate movement strategies during gait. In situations that are perceived as more threatening, older adults adopt more cautious strategies. For individuals with excessive fear, selecting adequate strategies might be troubling. Read More

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http://dx.doi.org/10.1038/s41598-020-66352-8DOI Listing

Maternal and fetal cardiovascular and metabolic effects of intra-operative uterine handling under general anesthesia during pregnancy in sheep.

Sci Rep 2020 Jul 2;10(1):10867. Epub 2020 Jul 2.

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.

A cohort study of 6,500,000 human pregnancies showed an increased risk of adverse fetal outcomes following abdominal but not non-abdominal surgery under general anesthesia. This may be the consequence of uterine handling during abdominal surgery. However, there are no data on any effects on the cardiometabolic physiology of the fetus or mother in response to uterine manipulation in otherwise healthy pregnancy. Read More

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http://dx.doi.org/10.1038/s41598-020-67714-yDOI Listing

Toward a New Molecular Taxonomy of Diffuse Large B-cell Lymphoma.

Cancer Discov 2020 Jul 2. Epub 2020 Jul 2.

British Columbia Cancer Centre for Lymphoid Cancer, Vancouver, British Columbia, Canada.

Diffuse large B-cell lymphoma (DLBCL) represents a grouping of clinically and biologically heterogeneous tumors. Application of advanced molecular technology has significantly expanded our knowledge of DLBCL pathobiology, allowing identification of subgroups with common, potentially targetable, biological themes. Here, we review the recent molecular analyses that could provide a paradigm shift to a new taxonomy, foundational to the rational transition to precision medicine. Read More

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http://dx.doi.org/10.1158/2159-8290.CD-20-0174DOI Listing

Rotational Anatomy of the Radius and Ulna: Surgical Implications.

J Hand Surg Am 2020 Jun 29. Epub 2020 Jun 29.

Hand and Upper Limb Centre, St. Joseph's Health Centre, London, Ontario.

Purpose: The rotational anatomy of the forearm bones is not well defined. This study aims to further the understanding of the torsion of the radius and ulna to better guide treatment.

Methods: Computed tomography images of 98 cadaveric forearms were obtained and 3-dimensional models of the radius and ulna were generated and analyzed. Read More

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http://dx.doi.org/10.1016/j.jhsa.2020.04.018DOI Listing

Neutrophil extracellular trapping and angiogenesis biomarkers after intravenous or inhalation anaesthesia with or without intravenous lidocaine for breast cancer surgery: a prospective, randomised trial.

Br J Anaesth 2020 Jun 29. Epub 2020 Jun 29.

Department of Histology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Background: Experimental and, retrospective, clinical data indicate that anaesthetic technique might influence the risk of metastasis after cancer surgery. Neutrophil extracellular trapping (NETosis) is an immunological mechanism strongly linked with increased metastatic risk. Similarly, vascular endothelial growth factor A is linked to angiogenesis implicated in recurrence. Read More

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http://dx.doi.org/10.1016/j.bja.2020.05.003DOI Listing

Moving Beyond the Rhetoric of Shared Decision-Making: Designing Personal Health Record Technology With Young Adults With Type 1 Diabetes.

Can J Diabetes 2020 Jul 1;44(5):434-441. Epub 2020 Apr 1.

Kootenay Lake Hospital Diabetes Clinic and Kootenay Boundary Division of Family Practice, Nelson, British Columbia, Canada.

Objectives: Engaging young adults with type 1 diabetes (T1D) in the self-management of daily tasks and decision-making provides opportunities for positive health outcomes. However, emerging adulthood and care transitions are associated with decreased clinic attendance and diabetes complications. Shared decision-making (SDM) is an optimal approach for health decisions; however, it has been difficult to implement in practice. Read More

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http://dx.doi.org/10.1016/j.jcjd.2020.03.009DOI Listing

Conducting a Mixed-Methods Study with Older Adults in Five Languages: Lessons from the Field.

Can J Aging 2020 Jun 19:1-10. Epub 2020 Jun 19.

Centre for Hip Health and Mobility, University of British Columbia & Vancouver Coastal Health Research Institute, Vancouver.

One third of older adults in Canada are foreign-born, yet there is a dearth of literature on this population. When our team set out to engage in a mixed-methods study on the physical activity and mobility of foreign-born older adults (FBOAs), we found limited guidance. The objective of this Research Note is to share the lessons that we learned in implementing a mixed-methods study in five languages, with 49 visible minority FBOAs from diverse ethno-cultural groups. Read More

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http://dx.doi.org/10.1017/S0714980820000100DOI Listing

Editorial on writing reviews for the .

Br J Nutr 2020 May;123(9):961-963

College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SKS7N 5E5, Canada.

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http://dx.doi.org/10.1017/S0007114520000185DOI Listing

Small renal masses in Latin-American population: characteristics and prognostic factors for survival, recurrence and metastasis - a multi-institutional study from LARCG database.

BMC Urol 2020 Jul 2;20(1):85. Epub 2020 Jul 2.

A.C. Camargo Cancer Center, Rua Antônio Prudente 211, Liberdade, São Paulo, 01509-010, Brazil.

Background: To evaluate demographic, clinical and pathological characteristics of small renal masses (SRM) (≤ 4 cm) in a Latin-American population provided by LARCG (Latin-American Renal Cancer Group) and analyze predictors of survival, recurrence and metastasis.

Methods: A multi-institutional retrospective cohort study of 1523 patients submitted to surgical treatment for non-metastatic SRM from 1979 to 2016. Comparisons between radical (RN) or partial nephrectomy (PN) and young or elderly patients were performed. Read More

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http://dx.doi.org/10.1186/s12894-020-00649-8DOI Listing

National Competencies for Registered Nurses in Primary Care: A Delphi Study.

West J Nurs Res 2020 Jul 3:193945920935590. Epub 2020 Jul 3.

Centre for Health Services and Policy Research and School of Nursing, University of British Columbia, Vancouver, BC, Canada.

A Delphi (consensus) process was used to obtain national agreement on competencies for registered nurses (RNs) in primary care. A draft of competencies was developed by key informants. Following this, nurses with primary care experience/expertise completed a Delphi survey to rate the importance of competency statements on a six-point Likert scale. Read More

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http://dx.doi.org/10.1177/0193945920935590DOI Listing

The application of novel field measurement and field evaluation protocols for assessing health care workers' exposure risk to antineoplastic drugs.

J Occup Environ Hyg 2020 Jul 2:1-10. Epub 2020 Jul 2.

School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.

Contamination of multiple antineoplastic drugs (ADs) on work surfaces presents an exposure concern for health care workers. Surface wipe sampling is a recognized method to evaluate the degree of contamination present. Our research team has previously reported on wipe sampling and analytical methods to simultaneously detect 10 commonly used ADs from a single wipe. Read More

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http://dx.doi.org/10.1080/15459624.2020.1777296DOI Listing

RSNA Expert Consensus Statement on Reporting Chest CT Findings Related to COVID-19: Interobserver Agreement Between Chest Radiologists.

Can Assoc Radiol J 2020 Jul 2:846537120938328. Epub 2020 Jul 2.

Department of Radiology, Vancouver General Hospital, British Columbia, Canada.

Purpose: To assess the interobserver variability between chest radiologists in the interpretation of the Radiological Society of North America (RSNA) expert consensus statement reporting guidelines in patients with suspected coronavirus disease 2019 (COVID-19) pneumonia in a setting with limited reverse transcription polymerase chain reaction testing availability.

Methods: Chest computed tomography (CT) studies in 303 consecutive patients with suspected COVID-19 were reviewed by 3 fellowship-trained chest radiologists. Cases were assigned an impression of typical, indeterminate, atypical, or negative for COVID-19 pneumonia according to the RSNA expert consensus statement reporting guidelines, and interobserver analysis was performed. Read More

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http://dx.doi.org/10.1177/0846537120938328DOI Listing
July 2020
0.584 Impact Factor

Temperament influences the relationship between symptom severity and adaptive functioning in children with autism spectrum disorder.

Autism 2020 Jul 2:1362361320933048. Epub 2020 Jul 2.

McMaster University, Canada.

Lay Abstract: Temperament is often thought of as behavioural traits that are relatively stable over time but can vary between individuals. Children diagnosed with autism spectrum disorder are often characterized as having 'reactive' and 'negative' temperaments when compared to same-aged peers with or without disabilities, which can negatively impact the development of adaptive functioning skills but little is known about variations of temperament between individual children diagnosed with autism spectrum disorder. This study aimed to (a) explore the variation of individual temperament traits within a sample of school-aged children with autism spectrum disorder to determine whether subgroups with similar trait profiles emerge and (b) examine whether temperament influences the relationship between autism symptoms and adaptive functioning outcomes. Read More

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http://dx.doi.org/10.1177/1362361320933048DOI Listing