143,487 results match your criteria British Journal of Diabetes and Vascular Disease [Journal]


The role of interspecific hybridization in adaptive potential at range margins.

Mol Ecol 2018 Dec;27(23):4653-4656

Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada.

Is interspecific hybridization an ordinary part of species biology? And if so, how evolutionarily important is it? These questions have been discussed in the botanical literature, in one form or another, at least since J.P. Lotsy early in the last century. Read More

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http://dx.doi.org/10.1111/mec.14927DOI Listing
December 2018

Validating the bivariate extreme value modeling approach for road safety estimation with different traffic conflict indicators.

Accid Anal Prev 2018 Dec 15;123:314-323. Epub 2018 Dec 15.

Department of Civil Engineering, The University of British Columbia, Canada.

A range of conflict indicators have been developed for traffic conflict observation. The various conflict indicators have been shown in earlier studies to be of different and sometimes independent nature. Therefore, there is a need to combine different indicators to gain better understanding of the underlying severity of traffic events and for more reliable safety analysis. Read More

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http://dx.doi.org/10.1016/j.aap.2018.12.007DOI Listing
December 2018

Letter.

Spine (Phila Pa 1976) 2019 Jan;44(2):E133

MEA Forensic Engineers & Scientists, Richmond, BC, Canada University of British Columbia, Vancouver, BC, Canada Semper Scientific, Mission Viejo, California Chalmers University of Technology, Göteborg, Sweden The Kolling Institute, University of Sydney, St Leonards, NSW, Australia Folksam, Stockholm, Sweden Chalmers University of Technology, Göteborg, Sweden.

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http://dx.doi.org/10.1097/BRS.0000000000002931DOI Listing
January 2019

Opioids in Arthroplasty: Mind the Gap Between North America and the Rest of the World.

J Bone Joint Surg Am 2018 Dec;100(24):2162-2171

Department of Orthopaedics, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.2106/JBJS.17.01422DOI Listing
December 2018

Influence of HIV Infection on the Natural History of Hepatocellular Carcinoma: Results From a Global Multicohort Study.

J Clin Oncol 2018 Dec 18:JCO1800885. Epub 2018 Dec 18.

19 James J. Peters Veterans Affairs Medical Center, Bronx, NY.

Purpose: Conflicting evidence indicates that HIV seropositivity may influence the outcome of patients with hepatocellular carcinoma (HCC), a leading cause of mortality in people with HIV. We aimed to verify whether HIV affected the overall survival (OS) of patients with HCC, independent of treatment and geographic origin.

Patients And Methods: We designed an international multicohort study of patients with HCC accrued from four continents who did not receive any anticancer treatment. Read More

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http://dx.doi.org/10.1200/JCO.18.00885DOI Listing
December 2018

Association of Anemia With Outcomes Among ST-Segment-Elevation Myocardial Infarction Patients Receiving Primary Percutaneous Coronary Intervention.

Circ Cardiovasc Interv 2018 Dec;11(12):e007175

Division of Cardiology, Department of Medicine (N.M., G.C.W., J.A.C., C.B.F.), University of British Columbia, Vancouver, Canada.

Background: Anemia may confer a poor prognosis among patients with the acute coronary syndrome. However, few data exist on the association of anemia with in-hospital outcomes, including bleeding, among ST-segment-elevation myocardial infarction patients receiving primary percutaneous coronary intervention.

Methods And Results: We identified 1919 ST-segment-elevation myocardial infarction patients who had undergone primary percutaneous coronary intervention within the Vancouver Coastal Health Authority (2007-2016) of whom 322 (16. Read More

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.007175DOI Listing
December 2018

Revisiting the Optimal Fractional Flow Reserve and Instantaneous Wave-Free Ratio Thresholds for Predicting the Physiological Significance of Coronary Artery Disease.

Circ Cardiovasc Interv 2018 Dec;11(12):e007041

NIHR Biomedical Research Centre and British Heart Foundation Centre of Excellence, School of Cardiovascular Medicine and Sciences, St Thomas' Campus, King's College London, United Kingdom.

Background: There has been a gradual upward creep of revascularization thresholds for both fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR), before the clinical outcome trials for both indices. The increase in revascularization that has potentially resulted is at odds with increasing evidence questioning the benefits of revascularizing stable coronary disease. Using an independent invasive reference standard, this study primarily aimed to define optimal thresholds for FFR and iFR and also aimed to compare the performance of iFR, FFR, and resting distal coronary pressure (Pd)/central aortic pressure (Pa). Read More

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http://dx.doi.org/10.1161/CIRCINTERVENTIONS.118.007041DOI Listing
December 2018

Profiling Hospital Performance Based on Mortality After Transcatheter Aortic Valve Replacement in Ontario, Canada.

Circ Cardiovasc Qual Outcomes 2018 Dec;11(12):e004947

Division of Cardiology, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada (G.E.-G., D.T.K., H.C.W.).

Background: Public reporting of hospital-level outcomes is increasingly common as a means to target quality improvement strategies to ensure the delivery of optimal care. Despite the rapid dissemination of transcatheter aortic valve replacement (TAVR), there is a paucity of reliable case-mix adjustment models for hospital profiling in TAVR. Our objective was to develop and evaluate different models for calculating risk-standardized all-cause mortality rates (RSMRs) post-TAVR. Read More

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http://dx.doi.org/10.1161/CIRCOUTCOMES.118.004947DOI Listing
December 2018

Maximal Static Respiratory and Sniff Pressures in Healthy Children: A Systematic Review and Meta-Analysis.

Ann Am Thorac Soc 2018 Dec 18. Epub 2018 Dec 18.

The Hospital for Sick Children, Department of Paediatrics, Toronto, Ontario, Canada ;

Rationale: Respiratory muscle strength in children can be assessed by maximal inspiratory (MIP), expiratory (MEP), and sniff nasal inspiratory pressures (SNIP). However, previous studies involved small cohorts of healthy children and reported wide reference ranges.

Objectives: To perform a systematic review to summarize existing reference ranges for MIP, MEP, and SNIP tests in healthy children and to conduct a meta-analysis to develop comprehensive prediction equations. Read More

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http://dx.doi.org/10.1513/AnnalsATS.201808-506OCDOI Listing
December 2018

Associations between smoking and extra-axial manifestations and disease severity in axial spondyloarthritis: results from the BSR Biologics Register for Ankylosing Spondylitis (BSRBR-AS).

Rheumatology (Oxford) 2018 Dec 14. Epub 2018 Dec 14.

Musculoskeletal biology I, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.

Objective: The effects of smoking on disease manifestations in axial SpA are inadequately described. Utilizing a large and well-characterized cohort, we investigated the association between smoking and extra-axial manifestations, and smoking and disease severity measures.

Methods: Baseline data from the British Society for Rheumatology Biologics Register for Ankylosing Spondylitis were explored. Read More

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http://dx.doi.org/10.1093/rheumatology/key371DOI Listing
December 2018

lordFAST: sensitive and Fast Alignment Search Tool for LOng noisy Read sequencing Data.

Bioinformatics 2019 Jan;35(1):20-27

Vancouver Prostate Centre, Vancouver, BC, Canada.

Motivation: Recent advances in genomics and precision medicine have been made possible through the application of high throughput sequencing (HTS) to large collections of human genomes. Although HTS technologies have proven their use in cataloging human genome variation, computational analysis of the data they generate is still far from being perfect. The main limitation of Illumina and other popular sequencing technologies is their short read length relative to the lengths of (common) genomic repeats. Read More

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http://dx.doi.org/10.1093/bioinformatics/bty544DOI Listing
January 2019

Anti-N-Methyl-D-Aspartate Receptor Encephalitis: A Review of Psychiatric Phenotypes and Management Considerations: A Report of the American Neuropsychiatric Association Committee on Research.

J Neuropsychiatry Clin Neurosci 2018 Dec 18:appineuropsych18010005. Epub 2018 Dec 18.

From the Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston (Sarkis); the Menninger Clinic and Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Tex. (Coffey); the Department of Psychiatry, University of Illinois at Chicago (Cooper); the British Columbia Neuropsychiatry Program and Vancouver General Hospital Epilepsy Program, University of British Columbia (Hassan); and the Department of Psychiatry, University of Oxford, Oxford, United Kingdom (Lennox).

Objective:: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune disorder characterized by prominent neuropsychiatric symptoms. Given the nature of its pathophysiology, psychiatrists tend to be one of the first clinicians encountering patients with the disease.

Methods:: In the present review of patients described in the literature with psychiatric symptoms, the authors aimed to characterize the psychiatric symptoms of the disease and its management in adults and adolescents as well as children (≤12 years old). Read More

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http://dx.doi.org/10.1176/appi.neuropsych.18010005DOI Listing
December 2018

American Head and Neck Society Endocrine Section clinical consensus statement: North American quality statements and evidence-based multidisciplinary workflow algorithms for the evaluation and management of thyroid nodules.

Head Neck 2018 Dec 18. Epub 2018 Dec 18.

Department of Otolaryngology, Massachusetts General Hospital, Boston, Massachusetts.

Background: Care for patients with thyroid nodules is complex and multidisciplinary, and research demonstrates variation in care. The objective was to develop clinical guidelines and quality metrics to reduce unwarranted variation and improve quality.

Methods: Multidisciplinary expert consensus and modified Delphi approach. Read More

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http://dx.doi.org/10.1002/hed.25526DOI Listing
December 2018

Screening-level risk assessment of methylmercury for non-anadromous Arctic char (Salvelinus alpinus).

Environ Toxicol Chem 2018 Dec 18. Epub 2018 Dec 18.

Faculty of Agricultural and Environmental Sciences, McGill University, Montréal, QC, H9 × 3V9, Canada.

Non-anadromous forms of Arctic char (Salvelinus alpinus), those that are restricted to lakes and rivers, typically have higher mercury concentrations than anadromous forms that migrate to and from the sea. Using tissue burden data from the literature and our own analyses, we performed a screening-level risk assessment of methylmercury for non-anadromous Arctic char. Our assessment included 1569 fish distributed across 83 sites. Read More

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http://dx.doi.org/10.1002/etc.4341DOI Listing
December 2018

Recrystallisation behaviour of a fully austenitic Nb-stabilised stainless steel.

J Microsc 2018 Dec 17. Epub 2018 Dec 17.

Materials Performance Centre, School of Materials, The University of Manchester, Manchester, UK.

We have performed an in-depth characterisation of the microstructure evolution of 20Cr-25Ni Nb-stabilised austenitic stainless steel during 1 h isochronal annealing up to 1100°C using scanning electron microscopy. This steel grade is used as cladding material in Advanced Gas-cooled fission reactors, due to its resistance to thermal creep and oxidation. The initial deformed microstructure undergoes recrystallisation via a strain-induced boundary migration mechanism, attaining a fully recrystallised microstructure at 850°C. Read More

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http://dx.doi.org/10.1111/jmi.12776DOI Listing
December 2018

Fast oxygen dynamics as a potential biomarker for epilepsy.

Sci Rep 2018 Dec 18;8(1):17935. Epub 2018 Dec 18.

Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.

Changes in brain activity can entrain cerebrovascular dynamics, though this has not been extensively investigated in pathophysiology. We assessed whether pathological network activation (i.e. Read More

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http://dx.doi.org/10.1038/s41598-018-36287-2DOI Listing
December 2018

Correcting for natural visuo-proprioceptive matching errors based on reward as opposed to error feedback does not lead to higher retention.

Exp Brain Res 2018 Dec 17. Epub 2018 Dec 17.

Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.

When asked to move their unseen hand-to-visual targets, people exhibit idiosyncratic but reliable visuo-proprioceptive matching errors. Unsurprisingly, vision and proprioception quickly align when these errors are made apparent by providing visual feedback of the position of the hand. However, retention of this learning is limited, such that the original matching errors soon reappear when visual feedback is removed. Read More

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http://dx.doi.org/10.1007/s00221-018-5456-3DOI Listing
December 2018

Alteration of the Retinoid Acid-CBP Signaling Pathway in Neural Crest Induction Contributes to Enteric Nervous System Disorder.

Front Pediatr 2018 3;6:382. Epub 2018 Dec 3.

Children's Nutrition Research Center, Children's Hospital of Chongqing Medical University, Chongqing, China.

Hirschsprung Disease (HSCR) and/or hypoganglionosis are common pediatric disorders that arise from developmental deficiencies of enteric neural crest cells (ENCCs). Retinoid acid (RA) signaling has been shown to affect neural crest (NC) development. However, the mechanisms underlying RA deficiency-induced HSCR or hypoganglionosis are not well-defined. Read More

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http://dx.doi.org/10.3389/fped.2018.00382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287626PMC
December 2018

Using ddPCR to assess the DNA yield of FFPE samples.

Biomol Detect Quantif 2018 Dec 7;16:5-11. Epub 2018 Nov 7.

Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.

Objectives: Detection of genomic alterations in diseases can be achieved with current molecular technologies. However, the molecules extracted from formalin-fixed, paraffin-embedded (FFPE) bio-samples are often limited possibly due to DNA fragmentation and crosslinking caused by the sample fixation and processing. The study objective was to design a droplet digital PCR (ddPCR) assay to assess the quality and quantity of DNA derived from various DNA extraction conditions on FFPE samples. Read More

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http://dx.doi.org/10.1016/j.bdq.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287546PMC
December 2018

Metabolic Evaluation of Epilepsy: A Diagnostic Algorithm With Focus on Treatable Conditions.

Front Neurol 2018 3;9:1016. Epub 2018 Dec 3.

Division of Genetics and Metabolism, Children's National Health System, Washington, DC, United States.

Although inborn errors of metabolism do not represent the most common cause of seizures, their early identification is of utmost importance, since many will require therapeutic measures beyond that of common anti-epileptic drugs, either in order to control seizures, or to decrease the risk of neurodegeneration. We translate the currently-known literature on metabolic etiologies of epilepsy (268 inborn errors of metabolism belonging to 21 categories, with 74 treatable errors), into a 2-tiered diagnostic algorithm, with the first-tier comprising accessible, affordable, and less invasive screening tests in urine and blood, with the potential to identify the majority of treatable conditions, while the second-tier tests are ordered based on individual clinical signs and symptoms. This resource aims to support the pediatrician, neurologist, biochemical, and clinical geneticists in early identification of treatable inborn errors of metabolism in a child with seizures, allowing for timely initiation of targeted therapy with the potential to improve outcomes. Read More

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http://dx.doi.org/10.3389/fneur.2018.01016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286965PMC
December 2018

Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer's human brains.

Nat Neurosci 2019 Jan 17;22(1):37-46. Epub 2018 Dec 17.

Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA.

Accumulation of tau and amyloid-β are two pathologic hallmarks of Alzheimer's disease. We conducted an epigenome-wide association study using the histone 3 lysine 9 acetylation (H3K9ac) mark in 669 aged human prefrontal cortices; in contrast with amyloid-β, tau protein burden had a broad effect on the epigenome, affecting 5,990 of 26,384 H3K9ac domains. Tau-related alterations aggregated in large genomic segments reflecting spatial chromatin organization, and the magnitude of these effects correlated with the segment's nuclear lamina association. Read More

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http://dx.doi.org/10.1038/s41593-018-0291-1DOI Listing
January 2019

Publisher Correction: Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels.

Nat Commun 2018 Dec 17;9(1):5401. Epub 2018 Dec 17.

Division of Cardiovascular Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.

The original version of this Article contained errors in the author affiliations.Martin R. Bennett was incorrectly associated with Nuclear Dynamics Programme, Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK. Read More

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http://dx.doi.org/10.1038/s41467-018-07887-3DOI Listing
December 2018

Disease-linked mutations in the phosphatidylcholine regulatory enzyme CCTα impair enzymatic activity and fold stability.

J Biol Chem 2018 Dec 17. Epub 2018 Dec 17.

Simon Fraser University.

CCT is the key regulatory enzyme in phosphatidylcholine (PC) synthesis and is activated by binding to PC-deficient membranes.  Mutations in the gene encoding CCTα (PCYT1A) cause three distinct pathologies in humans: Lipodystrophy, Spondylometaphyseal Dysplasia with Cone-Rod Dystrophy (SMD-CRD), and isolated retinal dystrophy.  Previous analyses showed that for some disease-linked PCYT1A variants steady state levels of CCTα and PC synthesis were reduced in patient fibroblasts, but other variants impaired PC synthesis with little effect on CCT levels. Read More

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http://dx.doi.org/10.1074/jbc.RA118.006457DOI Listing
December 2018

A case of Powassan encephalitis acquired in southern Quebec.

CMAJ 2018 Dec;190(50):E1478-E1480

Kelowna General Hospital (Sanderson), Kelowna, BC; University of British Columbia (Sanderson), Vancouver, BC; National Microbiology Laboratory (Lindsay), Public Health Agency of Canada, Winnipeg, Man.; Physical Medicine and Rehabilitation (Campbell), Élisabeth Bruyère Hospital, Ottawa, Ont.; BC Centre for Disease Control Public Health Laboratory (Morshed), Vancouver, BC.

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http://dx.doi.org/10.1503/cmaj.180905DOI Listing
December 2018

Reconciliation and Canada's overdose crisis: responding to the needs of Indigenous Peoples.

CMAJ 2018 Dec;190(50):E1466-E1467

British Columbia Centre on Substance Use (Lavalley, Kastor, Valleriani, McNeil); Western Aboriginal Harm Reduction Society (Kastor); Department of Medicine (Valleriani, McNeil), University of British Columbia, St. Paul's Hospital, Vancouver, BC

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http://dx.doi.org/10.1503/cmaj.181093DOI Listing
December 2018

Genetic data from nearly 63,000 women of European descent predicts DNA methylation biomarkers and epithelial ovarian cancer risk.

Authors:
Yaohua Yang Lang Wu Xiang Shu Yingchang Lu Xiao-Ou Shu Qiuyin Cai Alicia Beeghly-Fadiel Bingshan Li Fei Ye Andrew Berchuck Hoda Anton-Culver Susana Banerjee Javier Benitez Line Bjørge James D Brenton Ralf Butzow Ian G Campbell Jenny Chang-Claude Kexin Chen Linda S Cook Daniel W Cramer Anna DeFazio Joe Dennis Jennifer A Doherty Thilo Dork Diana M Eccles Digna Velez Edwards Peter A Fasching Renée T Fortner Simon A Gayther Graham G Giles Rosalind M Glasspool Ellen L Goode Marc T Goodman Jacek Gronwald Holly R Harris Florian Heitz Michelle A T Hildebrandt Estrid Høgdall Claus K Høgdall David G Huntsman Siddhartha P Kar Beth Y Karlan Linda E Kelemen Lambertus A Kiemeney Susanne K Kjaer Anita Koushik Diether Lambrechts Nhu D Le Douglas A Levine Leon F A G Massuger Keitaro Matsuo Taymaa May Iain A McNeish Usha Menon Francesmary Modugno Alvaro N Monteiro Patricia G Moorman Kirsten B Moysich Roberta B Ness Heli Nevanlinna Håkan Olsson N Charlotte Onland-Moret Sue K Park James Paul Celeste L Pearce Tanja Pejovic Catherine M Phelan Malcolm C Pike Susan J Ramus Elio Riboli Cristina Rodríguez-Antona Isabelle Romieu Dale P Sandler Joellen M Schildkraut Veronica W Setiawan Kang Shan Nadeem Siddiqui Weiva Sieh Meir J Stampfer Rebecca Sutphen Anthony J Swerdlow Lukasz Michal Szafron Soo Hwang Teo Shelley S Tworoger Jonathan P Tyrer Penelope M Webb Nicolas Wentzensen Emily White Walter C Willett Alicja Wolk Yin Ling Woo Anna H Wu Li Yan Drakoulis Yannoukakos Georgia Chenevix-Trench Thomas A Sellers Paul D P Pharoah Wei Zheng Jirong Long

Cancer Res 2018 Dec 17. Epub 2018 Dec 17.

Department of Medicine, Vanderbilt University Medical Center

DNA methylation is instrumental for gene regulation. Global changes in the epigenetic landscape have been recognized as a hallmark of cancer. However, the role of DNA methylation in epithelial ovarian cancer (EOC) remains unclear. Read More

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http://dx.doi.org/10.1158/0008-5472.CAN-18-2726DOI Listing
December 2018

Urothelial Carcinoma in Bladder Diverticula: A Multicenter Analysis of Characteristics and Clinical Outcomes.

Eur Urol Focus 2018 Dec 14. Epub 2018 Dec 14.

Department of Urology, Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.

Background: Urothelial carcinoma arising in a bladder diverticulum (UCBD) is uncommon, and data on treatment and outcome are sparse.

Objective: To analyze clinicopathological characteristics of UCBD and to compare outcome after radical cystectomy (RC) and partial cystectomy (PC).

Design, Setting, And Participants: Data of 115 UCBD patients treated with RC (n=81) or PC (n=34) between 2000 and 2016 were collected from 11 institutional databases and were analyzed retrospectively. Read More

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http://dx.doi.org/10.1016/j.euf.2018.12.002DOI Listing
December 2018

Electromyography and muscle biopsy in paediatric neuromuscular disorders - Evaluation of current practice and literature review.

Neuromuscul Disord 2018 Oct 31. Epub 2018 Oct 31.

Department of Clinical Neurophysiology, Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street, London, UK.

The conduct and interpretation of electromyography in children is considered difficult and therefore often avoided. We assessed the diagnostic accuracy of the paediatric electromyography protocol used in our tertiary reference centre and compared it to muscle biopsy results and clinical diagnosis. Electromyography was performed in unsedated children with suspected neuromuscular diseases between January 2010 and September 2017 and was analysed quantitatively. Read More

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http://dx.doi.org/10.1016/j.nmd.2018.10.003DOI Listing
October 2018

Perceptual and Interpretive Error in Diagnostic Radiology-Causes and Potential Solutions.

Acad Radiol 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiology and Imaging Sciences, University of Utah School of Medicine, 30 North 1900 East, Rm # 1A71, Salt Lake City, UT 84132, USA. Electronic address:

Interpretation of increasingly complex imaging studies involves multiple intricate tasks requiring visual evaluation, cognitive processing, and decision-making. At each stage of this process, there are opportunities for error due to human factors including perceptual and ergonomic conditions. Investigation into the root causes of interpretive error in radiology first began over a century ago. Read More

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http://dx.doi.org/10.1016/j.acra.2018.11.006DOI Listing
December 2018

Elimination of HIV transmission through novel and established prevention strategies among people who inject drugs.

Lancet HIV 2018 Dec 14. Epub 2018 Dec 14.

British Columbia Centre on Substance Use, Vancouver, BC, Canada; Department of Medicine, University of British Columbia, St Paul's Hospital, Vancouver, BC, Canada. Electronic address:

Despite the effectiveness of existing HIV prevention strategies for people who inject drugs (PWID), uncontrolled outbreaks of HIV among this group are common and occur around the world. In this Review, we summarise recent evidence for novel and established HIV prevention approaches to eliminate HIV transmission among PWID. Effective HIV prevention strategies include mobile needle and syringe programmes, pre-exposure prophylaxis, supervised injection facilities, and, to a lesser extent, some behavioural interventions. Read More

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http://dx.doi.org/10.1016/S2352-3018(18)30292-3DOI Listing
December 2018

Woman and Anesthetist in Bir Hakeim.

Authors:
Marc E Gentili

J Anesth Hist 2018 Oct 13;4(4):222-226. Epub 2018 Sep 13.

Department of Anesthesia and Intensive Care, Centre Hospitalier Saint-Grégoire, 35760 Saint-Grégoire, France. Electronic address:

Louise-Marie Lemanissier was a French physician who, after The Appeal of 18 June, joined with her husband the doctors of the Free French Forces (FFL) during World War II. The 1st Free French Division moved to Bir Hakeim on February 13, 1942, and the Lemanissier couple joined it in the Hadfield Spears Mobile Surgical Ambulance. Louise-Marie Lemanissier performed anesthesia among other duties. Read More

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http://dx.doi.org/10.1016/j.janh.2018.08.009DOI Listing
October 2018

Anesthetists and Intensivists Who Defied the Cold War.

J Anesth Hist 2018 Oct 18;4(4):205-208. Epub 2018 Oct 18.

Department of Anaesthesia, Critical Care & Pain Medicine, Royal Infirmary of Edinburgh, UK. Electronic address:

The term "Iron Curtain" described the barrier between communist East Europe and the capitalist West from 1945. Next the term "cold war" was introduced for the confrontation between these two sides without open warfare, because of the deterrent of atomic weapons. Restriction in collaboration between those on either side extended to the medical profession, including anesthesia, resuscitation and intensive care. Read More

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http://dx.doi.org/10.1016/j.janh.2018.10.002DOI Listing
October 2018

Self-reported use of family physician, chiropractor and physiotherapy services among adult Canadians with chronic back disorders: an observational study.

BMC Health Serv Res 2018 Dec 17;18(1):970. Epub 2018 Dec 17.

School of Rehabilitation Science & Canadian Centre for Health and Safety in Agriculture (CCHSA), College of Medicine, University of Saskatchewan, Health Sciences Building, E-Wing, Suite 3400, 104 Clinic Place, Saskatoon, S7N 2Z4, SK, Canada.

Background: Chronic back disorders (CBD) are prevalent, costly, and among the most common reasons for seeking primary care; however, little is known regarding the comparative use of family physician, chiropractic, and physiotherapy services among people with CBD in Canada. Elucidating these differences may identify potential gaps in access to care and inform the development of strategies to improve access. The research objectives were to investigate patterns of health care use and to profile factors associated with self-reported use of family physicians, chiropractors, and physiotherapists among adult Canadians with CBD. Read More

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http://dx.doi.org/10.1186/s12913-018-3790-6DOI Listing
December 2018

Treatment of alcohol use disorder among people of South Asian ancestry in Canada and the United States: A narrative review.

J Ethn Subst Abuse 2018 Dec 17:1-13. Epub 2018 Dec 17.

a University of British Columbia , Vancouver , BC , Canada.

To explore access and treatment for alcohol use disorders (AUDs) among people of South Asian ancestry living in Canada or the United State, EQUATOR guidelines were applied to 34 manuscripts identified through an English language literature search (1946-2017) for this narrative review. The population studied has poor access to and engagement with treatment for AUD. Early evidence suggests benefit from adopting language-specific materials, offering South Asian-specific therapy groups, and incorporating traditional healers. Read More

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http://dx.doi.org/10.1080/15332640.2018.1532855DOI Listing
December 2018

Hydroxynorketamine: Implications for the NMDA Receptor Hypothesis of Ketamine's Antidepressant Action.

Chronic Stress (Thousand Oaks) 2017 Jan-Dec;1. Epub 2017 Dec 12.

Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.

The prevailing hypothesis of ketamine's unique antidepressant effects implicates N-methyl-d-aspartate receptor (NMDAR) inhibition-dependent enhancement of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated transmission, activation of intracellular signalling pathways and increased synaptogenesis. Recently, however, a seminal study by Zanos et al. directly challenged the NMDAR hypothesis of ketamine with the claim that an active ketamine metabolite, (2R,6R)-hydroxynorketamine, devoid of NMDAR binding properties or key side effects of its parent compound, is both necessary and sufficient for ketamine's antidepressant effects in rodents. Read More

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December 2017

Gaze allocation in face-to-face communication is affected primarily by task structure and social context, not stimulus-driven factors.

Cognition 2018 Dec 14;184:28-43. Epub 2018 Dec 14.

Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, the Netherlands; Developmental Psychology, Utrecht University, Utrecht, the Netherlands; Brain Center Rudolf Magnus, University Medical Center, Utrecht, the Netherlands.

Gaze allocation to human faces has recently been shown to be greatly dependent on the social context. However, what has not been considered explicitly here, is how gaze allocation may be supportive of the specific task that individuals carry out. In the present study, we combined these two insights. Read More

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http://dx.doi.org/10.1016/j.cognition.2018.12.005DOI Listing
December 2018

Guidelines Versus Guidelines.

Ann Intern Med 2018 Dec;169(12):895-896

Johns Hopkins Bayview Medical Center, Baltimore, Maryland (T.F.).

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http://annals.org/article.aspx?doi=10.7326/L18-0559
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http://dx.doi.org/10.7326/L18-0559DOI Listing
December 2018
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Long-Term Outcomes Among Patients Discharged From the Hospital With Moderate Anemia: A Retrospective Cohort Study.

Ann Intern Med 2018 Dec 18. Epub 2018 Dec 18.

Kaiser Permanente Northern California, Oakland, California (D.G.M., C.L., P.K., V.X.L., G.J.E.).

Background: Randomized clinical trial findings support decreased red blood cell (RBC) transfusion and short-term tolerance of in-hospital anemia. However, long-term outcomes related to changes in transfusion practice have not been described.

Objective: To describe the prevalence of anemia at and after hospital discharge and associated morbidity and mortality events. Read More

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http://annals.org/article.aspx?doi=10.7326/M17-3253
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http://dx.doi.org/10.7326/M17-3253DOI Listing
December 2018
2 Reads

A Laboratory Evaluation of Contextual Factors Affecting Ratings of Speech in Noise: Implications for Ecological Momentary Assessment.

Ear Hear 2018 Dec 14. Epub 2018 Dec 14.

School of Audiology & Speech Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

Objectives: As hearing aid outcome measures move from retrospective to momentary assessments, it is important to understand how contextual factors influence subjective ratings. Under laboratory-controlled conditions, we examined whether subjective ratings changed as a function of acoustics, response timing, and task variables.

Design: Eighteen adults (age 21 to 85 years; M = 51. Read More

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http://dx.doi.org/10.1097/AUD.0000000000000686DOI Listing
December 2018

The Value of Imaging-The Case for Coronary Computed Tomography Angiography.

J Thorac Imaging 2019 Jan;34(1):2-3

Department of Medical Imaging and Division of Cardiology, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1097/RTI.0000000000000381DOI Listing
January 2019

Cost-Utility Study of the Economics of Bunion Correction Surgery.

Foot Ankle Int 2018 Dec 17:1071100718815663. Epub 2018 Dec 17.

3 Department of Orthopaedics, University of British Columbia, Vancouver, BC, Canada.

Background:: Bunion correction surgery is a very common procedure to improve patients' pain and physical function attributable to a misaligned first metatarsophalangeal joint. The objective of this study was to apply a health utility framework to estimate the cost utility of bunion correction surgery.

Methods:: Patients were prospectively recruited from the population of patients seen in a lower-extremity orthopedic clinic and scheduled for isolated bunion surgery. Read More

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http://dx.doi.org/10.1177/1071100718815663DOI Listing
December 2018
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Minimum Information about an Uncultivated Virus Genome (MIUViG).

Nat Biotechnol 2018 Dec 17. Epub 2018 Dec 17.

US Department of Energy Joint Genome Institute, Walnut Creek, California, USA.

We present an extension of the Minimum Information about any (x) Sequence (MIxS) standard for reporting sequences of uncultivated virus genomes. Minimum Information about an Uncultivated Virus Genome (MIUViG) standards were developed within the Genomic Standards Consortium framework and include virus origin, genome quality, genome annotation, taxonomic classification, biogeographic distribution and in silico host prediction. Community-wide adoption of MIUViG standards, which complement the Minimum Information about a Single Amplified Genome (MISAG) and Metagenome-Assembled Genome (MIMAG) standards for uncultivated bacteria and archaea, will improve the reporting of uncultivated virus genomes in public databases. Read More

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http://www.nature.com/doifinder/10.1038/nbt.4306
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http://dx.doi.org/10.1038/nbt.4306DOI Listing
December 2018
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VNUT and VMAT2 segregate within sympathetic varicosities and localize near preferred Cav2 isoforms in the rat tail artery.

Am J Physiol Heart Circ Physiol 2019 Jan 12;316(1):H89-H105. Epub 2018 Oct 12.

Department of Biomedical Physiology and Kinesiology, Simon Fraser University , Burnaby, British Columbia , Canada.

ATP and norepinephrine (NE) are coreleased from peripheral sympathetic nerve terminals. Whether they are stored in the same vesicles has been debated for decades. Preferential dependence of NE or ATP release on Ca influx through specific voltage-gated Ca channel (Cav2) isoforms suggests that NE and ATP are stored in separate vesicle pools, but simultaneous imaging of NE and ATP containing vesicles within single varicosities has not been reported. Read More

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https://www.physiology.org/doi/10.1152/ajpheart.00560.2018
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http://dx.doi.org/10.1152/ajpheart.00560.2018DOI Listing
January 2019
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Death of the King: The Introduction of Vaccination into Nepal in 1816.

Authors:
Susan Heydon

Med Hist 2019 Jan;63(1):24-43

This article explores the introduction of smallpox vaccination into Nepal in 1816 at the request of the Nepalese government; the king, however, was not vaccinated, contracted the disease and died. British hopes that vaccination would be extended throughout the country did not eventuate. The article examines the significance of this early appearance of vaccination in Nepal for both Nepalese and British, and relates it to the longer history of smallpox control and eventual eradication. Read More

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http://dx.doi.org/10.1017/mdh.2018.61DOI Listing
January 2019

'If We Are to Believe the Psychologists …': Medicine, Psychoanalysis and Breastfeeding in Britain, 1900-55.

Authors:
Katharina Rowold

Med Hist 2019 Jan;63(1):61-81

In 1942, the British Minister of Health commissioned a report from the newly established Advisory Committee on Mothers and Young Children into 'What can be done to intensify the effort to secure more breast feeding of infants?'. To make their case, the members of the sub-committee put in charge of the report sought expert testimony on the benefits of breastfeeding. They consulted medical officers of health, maternity and child-welfare officers, health visitors, midwives, obstetricians, paediatricians and a physician in private practice. Read More

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http://dx.doi.org/10.1017/mdh.2018.63DOI Listing
January 2019

Effect of dialect on phonological analysis.

Clin Linguist Phon 2018 Dec 16:1-22. Epub 2018 Dec 16.

a Division of Graduate Medical Studies , National University of Singapore , Singapore.

It is important to understand a child's language background, to ensure appropriate assessment, diagnosis and treatment of speech sound disorders. Singapore is home to various cultures and languages, and local speech norms are needed to provide an accurate reference for assessing phonological disorders in the local population. This study aims to establish normative data and better understand the English phonological development of English-Mandarin bilingual preschoolers in Singapore, aged 3; 6-4; 5 years. Read More

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http://dx.doi.org/10.1080/02699206.2018.1550812DOI Listing
December 2018

Distinction of Condylomata Acuminata from Vulvar Vestibular Papules or Pearly Penile Papules Using Ki-67 Immunostaining.

J Cutan Med Surg 2018 Dec 17:1203475418819992. Epub 2018 Dec 17.

1 Departments of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada.

Background:: Ki-67 is an immunohistochemical stain used as a nuclear proliferation marker. It is nonspecific, and is expressed in all active phases of the cell cycle. Vulvar vestibular papules in women and pearly penile papules in men are benign fibrous papules on the genitals, are noninfectious, and do not require treatment. Read More

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http://dx.doi.org/10.1177/1203475418819992DOI Listing
December 2018
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