145,582 results match your criteria British Journal of Anaesthetic and Recovery Nursing [Journal]


Phase I dose-finding study for melatonin in pediatric oncology patients with relapsed solid tumors.

Pediatr Blood Cancer 2019 Feb 20:e27676. Epub 2019 Feb 20.

Division of Pediatric Hematology/Oncology, The Hospital for Sick Children, University of Toronto, Toronto, Canada.

Background: Melatonin is a natural health product used for sleep disturbances. In preliminary studies of adults with advanced cancer, 20 mg of melatonin daily was associated with reduction in anorexia and weight loss-symptoms that also impact pediatric oncology patients. High doses of melatonin have not been studied in pediatrics. Read More

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http://dx.doi.org/10.1002/pbc.27676DOI Listing
February 2019

Transverse tendon stiffness is reduced in people with Achilles tendinopathy: A cross-sectional study.

PLoS One 2019 20;14(2):e0211863. Epub 2019 Feb 20.

Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, Vancouver, Canada.

Objectives: The objective of the current cross-sectional study was to examine Achilles tendon transverse stiffness in a group of recreational runners with Achilles tendinopathy, in comparison to an asymptomatic group of runners with similar training history. We also aimed to determine the between-week intra-individual reliability of this measurement technique.

Design: Cross-sectional cohort study. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211863PLOS
February 2019

Cost of illness and program of dengue: A systematic review.

PLoS One 2019 20;14(2):e0211401. Epub 2019 Feb 20.

Faculty of Pharmacy, Federal University of Goiás, Goiás, Brazil.

Background: Studies on dengue related to the cost of illness and cost of the program are factors to describe the economic burden of dengue, a neglected disease that has global importance in public health. These studies are often used by health managers in optimizing financial resources. A systematic review of studies estimating the cost of dengue was carried out, comparing the costs between the studies and examining the cost drivers regarding the methodological choices. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211401PLOS
February 2019

Impaired posture, movement preparation, and execution during both paretic and nonparetic reaching following stroke.

J Neurophysiol 2019 Feb 20. Epub 2019 Feb 20.

University of Maryland School of Medicine, United States.

Posture and movement planning, preparation, and execution of a goal-directed reaching movement are impaired in individuals with stroke. No studies have shown whether the deficits are generally impaired or are specific to the lesioned hemisphere/ paretic arm. This study utilized StartReact (SR) responses elicited by loud acoustic stimuli (LAS) to investigate the preparation and execution of anticipatory postural adjustments (APAs) and reach movement response during both the paretic and nonparetic arm reaching in individuals with stroke and age-matched healthy controls. Read More

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http://dx.doi.org/10.1152/jn.00694.2018DOI Listing
February 2019

Considering culture and ethnicity in family-centred dementia care at the end of life: a case study.

Int J Palliat Nurs 2019 Feb;25(2):56-64

Head of Research and Publications, Dementia UK, London.

Background:: The UK older population is becoming increasingly ethnically diverse, with a projected eight-fold increase in dementia among black, Asian and minority ethnic communities over the next 30 years, compared with a two-fold increase in white British people with dementia.

Aims:: This Admiral Nurse case study explores an understanding of culture and ethnic background in families' experiences of dementia and caring using a culturagram assessment framework.

Findings:: The culturagram enabled a more comprehensive assessment, so that care delivery was sensitive to the specific cultural and ethnicity issues in a relationship-centred approach to dementia care. Read More

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http://dx.doi.org/10.12968/ijpn.2019.25.2.56DOI Listing
February 2019

Fumarate hydratase deficient renal cell carcinoma: Chromosomal numerical aberration analysis of 12 cases.

Ann Diagn Pathol 2019 Feb 10;39:63-68. Epub 2019 Feb 10.

Department of Pathology, Charles University in Prague, Faculty of Medicine in Plzeň, University Hospital Plzen, Pilsen, Czech Republic. Electronic address:

Hereditary leiomyomatosis and renal cell carcinoma-associated renal cell carcinoma (HLRCC)/fumarate hydratase deficient renal cell carcinoma (FHRCC) is defined by molecular genetic changes (mutation/LOH in fumarate hydratase (FH) gene). We investigated chromosomal numerical aberration pattern (CNV) in FHRCC/HLRCC using array comparative genomic hybridization analysis and low pass whole genome sequencing. Genetic analysis was successfully completed in 12 tumors. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2019.02.008DOI Listing
February 2019

Effects of cold temperature and snowfall on stroke mortality: A case-crossover analysis.

Environ Int 2019 Feb 20;126:89-95. Epub 2019 Feb 20.

Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada; Institut national de santé publique du Québec, Montreal, Quebec, Canada; University of Montreal Hospital Research Centre, Montreal, Quebec, Canada. Electronic address:

Background: We sought to determine if cold temperature and snowfall are independently associated with stroke mortality, and whether effects differ between hemorrhagic and ischemic stroke.

Materials And Methods: We conducted a case-crossover study of 13,201 stroke deaths utilizing weather records between the months of November and April for Quebec, Canada from 1981 to 2015. We compared exposure to cold temperature and snowfall with controls days when stroke death did not occur. Read More

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http://dx.doi.org/10.1016/j.envint.2019.02.031DOI Listing
February 2019

Vasopressin in Vasodilatory Shock.

Crit Care Clin 2019 Apr 23;35(2):247-261. Epub 2019 Jan 23.

Division of Critical Care Medicine, Centre for Heart Lung Innovation, University of British Columbia, 1081 Burrard Street, Vancouver, British Columbia V6Z 1Y6, Canada. Electronic address:

Vasodilatory shock is the final common pathway for all forms of severe shock, with sepsis the most common primary etiology and the leading cause of critical illness-related mortality. The pathophysiology of this condition remains incompletely elucidated. Deficiency of the neuropeptide hormone vasopressin seems to play a significant role. Read More

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http://dx.doi.org/10.1016/j.ccc.2018.11.004DOI Listing

Identifying Extrinsic versus Intrinsic Drivers of Variation in Cell Behavior in Human iPSC Lines from Healthy Donors.

Cell Rep 2019 Feb;26(8):2078-2087.e3

Centre for Stem Cells and Regenerative Medicine, King's College London, Floor 28, Tower Wing, Guy's Hospital, Great Maze Pond, London SE1 9RT, UK. Electronic address:

Large cohorts of human induced pluripotent stem cells (iPSCs) from healthy donors are a potentially powerful tool for investigating the relationship between genetic variants and cellular behavior. Here, we integrate high content imaging of cell shape, proliferation, and other phenotypes with gene expression and DNA sequence datasets from over 100 human iPSC lines. By applying a dimensionality reduction approach, Probabilistic Estimation of Expression Residuals (PEER), we extracted factors that captured the effects of intrinsic (genetic concordance between different cell lines from the same donor) and extrinsic (cell responses to different fibronectin concentrations) conditions. Read More

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http://dx.doi.org/10.1016/j.celrep.2019.01.094DOI Listing
February 2019

Incidence and prevalence of dementia associated with transient ischaemic attack and stroke: analysis of the population-based Oxford Vascular Study.

Lancet Neurol 2019 Mar 12;18(3):248-258. Epub 2019 Feb 12.

Centre for Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital and University of Oxford, Oxford, UK.

Background: Risk of dementia after stroke is a major concern for patients and carers. Reliable data for risk of dementia, particularly after transient ischaemic attack or minor stroke, are scarce. We studied the risks of, and risk factors for, dementia before and after transient ischaemic attack and stroke. Read More

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http://dx.doi.org/10.1016/S1474-4422(18)30442-3DOI Listing

A winter energetics model for bobcats in a deep snow environment.

J Therm Biol 2019 Feb 8;80:56-63. Epub 2019 Jan 8.

Department of Biology, University of British Columbia Okanagan, 1177 Research Road, Kelowna, BC, Canada V1V 1V7. Electronic address:

Understanding basic energetic requirements of wildlife species is critical to evaluate how individuals persist in their current environments as well as to forecast responses to changed climates or habitats. Indeed, northern range limits are often thought to reflect harsh abiotic conditions that exceed the capacity of individuals to stay in energetic balance. Bobcats (Lynx rufus) occur across much of North America; at northern latitudes, they face winter challenges such as deep snows, cold temperatures, and possible food scarcity. Read More

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http://dx.doi.org/10.1016/j.jtherbio.2019.01.006DOI Listing
February 2019

Cognitive deficits in problematic internet use: meta-analysis of 40 studies.

Br J Psychiatry 2019 Feb 20:1-8. Epub 2019 Feb 20.

Department of Psychiatry,University of Cambridge; andPeterborough NHS Foundation Trust,Cambridge,UK.

Background: Excessive use of the internet is increasingly recognised as a global public health concern. Individual studies have reported cognitive impairment in problematic internet use (PIU), but have suffered from various methodological limitations. Confirmation of cognitive deficits in PIU would support the neurobiological plausibility of this disorder. Read More

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http://dx.doi.org/10.1192/bjp.2019.3DOI Listing
February 2019

Evidence for dynamic resource partitioning between two sympatric reef shark species within the British Indian Ocean Territory.

J Fish Biol 2019 Feb 19. Epub 2019 Feb 19.

Great Lakes Institute for Environmental Research, University of Windsor, Windsor, Canada.

Stable-isotope analyses (δ C, δ N and δ S) of multiple tissues (fin, muscle, red blood cells and plasma), revealed ontogenetic shifts in resource use by grey reef sharks Carcharhinus amblyrhynchos and resource partitioning with silvertip sharks Carcharhinus albimarginatus within the British Indian Ocean Territory marine protected area (MPA). Resource partitioning varied temporally, with C. albimarginatus feeding on more pelagic prey during October to January, potentially attributable to an influx of pelagic prey from outside the MPA at that time. Read More

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http://dx.doi.org/10.1111/jfb.13938DOI Listing
February 2019

Haematological management of major bleeding associated with direct oral anticoagulants - UK experience.

Br J Haematol 2019 Feb 19. Epub 2019 Feb 19.

Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

The lack of antidotes for activated factor X-inhibitor direct oral anticoagulants (DOACs) means that management of bleeding consists largely of existing supportive therapies. This study aimed to: (i) examine the relative frequency of DOAC-related major bleeding in relation to DOAC prescriptions over the study period; (ii) describe the presentation and haematological management of DOAC-related major bleeding; and (iii) evaluate the association between the use of prothrombin-complex-concentrate (PCC) and in-hospital mortality. Over a 3-year period, 32 UK hospitals submitted data on haematological management of DOAC-related bleeding. Read More

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http://dx.doi.org/10.1111/bjh.15808DOI Listing
February 2019

Life-history variation along environmental and harvest clines of a northern freshwater fish: plasticity and adaptation.

J Anim Ecol 2019 Feb 19. Epub 2019 Feb 19.

University of Calgary, Department of Biological Sciences, 2500 University Drive N.W, Calgary, Alberta, T2N 1N4.

Plasticity, local adaptation, and evolutionary tradeoffs drive clinal variation in traits associated with lifetime growth. Disentangling the processes and determinants that cause these traits to vary helps to understand species' responses to changing environments. This is particularly urgent for exploited populations, where size-selective harvest can induce life-history evolution. Read More

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http://dx.doi.org/10.1111/1365-2656.12965DOI Listing
February 2019

Underwire bra complicating a gunshot injury.

Can J Anaesth 2019 Feb 19. Epub 2019 Feb 19.

Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/s12630-019-01319-6DOI Listing
February 2019

Inappropriate inclusion of multiple studies in a meta-analysis of randomized controlled trials of atorvastatin loading prior to percutaneous coronary intervention for acute coronary syndrome.

Eur Heart J 2019 Feb 20. Epub 2019 Feb 20.

Division of General Internal Medicine, Center for Research on Health Care Data Center (CRHC-DC), Center for Clinical Trials & Data Coordination (CCDC), University of Pittsburgh School of Medicine, 200 Meyran Avenue, Pittsburgh PA 15241, USA.

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http://dx.doi.org/10.1093/eurheartj/ehz072DOI Listing
February 2019

Extreme spikes in DMS flux double estimates of biogenic sulfur export from the Antarctic coastal zone to the atmosphere.

Sci Rep 2019 Feb 19;9(1):2233. Epub 2019 Feb 19.

GELIFES, University of Groningen, 9700 CC, Groningen, The Netherlands.

Biogenic dimethylsulfide (DMS) is a significant contributor to sulfur flux from the oceans to the atmosphere, and the most significant source of aerosol non sea-salt sulfate (NSS-SO), a key regulator of global climate. Here we present the longest running time-series of DMS-water (DMS) concentrations in the world, obtained at the Rothera Time-Series (RaTS) station in Ryder Bay, West Antarctic Peninsula (WAP). We demonstrate the first ever evaluation of interseasonal and interannual variability in DMS and associated flux to the atmosphere from the Antarctic coastal zone and determine the scale and importance of the region as a significant source of DMS. Read More

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http://dx.doi.org/10.1038/s41598-019-38714-4DOI Listing
February 2019

Molecular basis for the potent inhibition of the emerging carbapenemase VCC-1 by avibactam.

Antimicrob Agents Chemother 2019 Feb 19. Epub 2019 Feb 19.

Department of Microbiology, University of Manitoba, Winnipeg, Canada, R3T 2N2

In 2016 we identified a new class A carbapenemase, VCC-1, in nontoxigenic that had been isolated from retail shrimp imported into Canada for human consumption. Shortly thereafter, seven additional VCC-1 producing were isolated along the German coastline. These isolates appear to have acquired the VCC-1 gene () independently from the Canadian isolate, suggesting is mobile and widely distributed. Read More

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http://dx.doi.org/10.1128/AAC.02112-18DOI Listing
February 2019

Making headlines: an analysis of US government-funded cancer research mentioned in online media.

BMJ Open 2019 Feb 19;9(2):e025783. Epub 2019 Feb 19.

Simon Fraser University at Harbour Centre, Vancouver, British Columbia, Canada.

Objective: To characterise how online media coverage of journal articles on cancer funded by the US government varies by cancer type and stage of the cancer control continuum and to compare the disease prevalence rates with the amount of funded research published for each cancer type and with the amount of media attention each receives.

Design: A cross-sectional study.

Setting: The United States. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025783DOI Listing
February 2019

'Just because I'm old it doesn't mean I have to be fat': a qualitative study exploring older adults' views and experiences of weight management.

BMJ Open 2019 Feb 19;9(2):e025680. Epub 2019 Feb 19.

Department of Behavioural Science and Health, University College London, London, UK.

Objectives: The aim of this study was to explore older adults' beliefs about the appropriateness of weight management, and how their experiences and expectations of weight management have changed as they have got older.

Design: Qualitative semistructured interview study.

Setting: UK. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025680DOI Listing
February 2019

Temporal trends in relative survival following percutaneous coronary intervention.

BMJ Open 2019 Feb 19;9(2):e024627. Epub 2019 Feb 19.

Keele Cardiovascular Research Group, Centre for Prognosis Research, Institute of Primary Care and Health Sciences, University of Keele, Keele, UK.

Objective: Percutaneous coronary intervention (PCI) has seen substantial shifts in patient selection in recent years that have increased baseline patient mortality risk. It is unclear to what extent observed changes in mortality are attributable to background mortality risk or the indication and selection for PCI itself. PCI-attributable mortality can be estimated using relative survival, which adjusts observed mortality by that seen in a matched control population. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02462
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http://dx.doi.org/10.1136/bmjopen-2018-024627DOI Listing
February 2019
1 Read

Qualitative study to identify ethnicity-specific perceptions of and barriers to asthma management in South Asian and White British children with asthma.

BMJ Open 2019 Feb 19;9(2):e024545. Epub 2019 Feb 19.

Mary Seacole Research Centre, DeMonfort University, Leicester, UK.

Objective: This paper draws on the data from the Management and Interventions for Asthma (MIA) study to explore the perceptions and experiences of asthma in British South Asian children using semi-structured interviews. A comparable cohort of White British children was recruited to identify whether any emerging themes were subject to variation between the two groups so that generic and ethnicity-specific themes could be identified for future tailored intervention programmes for South Asian children with asthma.

Setting: South Asian and White British children with asthma took part in semi-structured interviews in Leicester, UK. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02454
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http://dx.doi.org/10.1136/bmjopen-2018-024545DOI Listing
February 2019
1 Read

Temporal trends in severe morbidity and mortality associated with ectopic pregnancy requiring hospitalisation in Washington State, USA: a population-based study.

BMJ Open 2019 Feb 19;9(2):e024353. Epub 2019 Feb 19.

Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia, Canada.

Objective: To examine temporal trend in maternal mortality/severe morbidity associated with hospitalisation due to ectopic pregnancy.

Design: A population-based observational study.

Setting And Participants: All women hospitalised for ectopic pregnancy in Washington State, USA, 1987-2014 (n=20 418). Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02435
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http://dx.doi.org/10.1136/bmjopen-2018-024353DOI Listing
February 2019
1 Read

Place-specific factors associated with adverse maternal and perinatal outcomes in Southern Mozambique: a retrospective cohort study.

BMJ Open 2019 Feb 19;9(2):e024042. Epub 2019 Feb 19.

Department of Medicine, Yale New Haven Health System, New Haven, Connecticut, USA.

Objectives: To identify and measure the place-specific determinants that are associated with adverse maternal and perinatal outcomes in the southern region of Mozambique.

Design: Retrospective cohort study. Choice of variables informed by literature and Delphi consensus. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024042DOI Listing
February 2019

Feasibility of working with a wholesale supplier to co-design and test acceptability of an intervention to promote smaller portions: an uncontrolled before-and-after study in British Fish & Chip shops.

BMJ Open 2019 Feb 19;9(2):e023441. Epub 2019 Feb 19.

Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.

Objectives: To explore the feasibility of working with a wholesale supplier to co-design and deliver, and to assess the acceptability of, an intervention to promote smaller portions in Fish & Chip shops.

Design: Uncontrolled before-and-after study.

Setting: Fish & Chip shops in northern England, 2016. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023441DOI Listing
February 2019

Outcomes related to respiratory syncytial virus with an abbreviated palivizumab regimen in children with congenital heart disease: a descriptive analysis.

CMAJ Open 2019 Jan-Mar;7(1):E88-E93. Epub 2019 Feb 18.

Children's & Women's Health Centre of British Columbia (Claydon, Popescu, Christopherson, Human, Solimano, Lavoie); Divisions of Neonatology (Popescu, Shaiba, Solimano, Lavoie) and Cardiology (Human), Department of Pediatrics, University of British Columbia; British Columbia Children's Hospital Research Institute (Popescu, Human, Lavoie), Vancouver, BC; Victoria General Hospital (Taylor), Victoria, BC; University of Toronto (Shaiba), Toronto, Ont.

Background: It has been hypothesized that 4 doses of palivizumab, a neutralizing monoclonal antibody against respiratory syncytial virus (RSV), administered during a fixed-date RSV season may reduce hospital admissions comparably to the standard 5-dose schedule. We report outcomes in children with congenital heart disease approved to receive this 4-dose palivizumab schedule in British Columbia.

Methods: We performed a population-based descriptive cohort analysis of all 406 approved palivizumab courses over 4 seasons (2012/13 to 2015/16) in 325 children with hemodynamically significant congenital heart disease enrolled in the British Columbia RSV Immunoprophylaxis Program. Read More

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http://cmajopen.ca/lookup/doi/10.9778/cmajo.20180167
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http://dx.doi.org/10.9778/cmajo.20180167DOI Listing
February 2019
1 Read

Parents' perceptions of obesity prevention during infancy: a qualitative study.

CMAJ Open 2019 Jan-Mar;7(1):E81-E87. Epub 2019 Feb 18.

Department of Family Practice (Hale) and School of Population and Public Health (Lee), University of British Columbia; British Columbia Children's Hospital and SCOPE BC (Sustainable Childhood Obesity Prevention through Community Engagement) (Amed, Keidar), Vancouver, BC; East Kootenay Division of Family Practice (Purcell), Cranbrook, BC; College of Medicine (Farhadi), University of Saskatchewan, Saskatoon, Sask.

Background: Infancy appears to be a critical period for establishing a person's weight set point. It remains unclear which interventions during infancy may be most effective in preventing later obesity and which ones are most acceptable to parents. The aim of this study was to examine the attitudes of parents of children aged 2 years and under toward different obesity prevention messages and their preferences with regard to these messages. Read More

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http://dx.doi.org/10.9778/cmajo.20180066DOI Listing
February 2019
1 Read

Qualitative study to elicit patients' and primary care physicians' perspectives on the use of a self-management mobile health application for knee osteoarthritis.

BMJ Open 2019 Feb 1;9(1):e024016. Epub 2019 Feb 1.

Department of Community Health Sciences, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.

Objective: To elicit perspectives of family physicians and patients with knee osteoarthritis (KOA) on KOA, its treatment/management and the use of a mobile health application (app) to help patients self-manage their KOA.

Design: A qualitative study using Cognitive Task Analysis for physician interviews and peer-to-peer semistructured interviews for patients according to the Patient and Community Engagement Research (PaCER) method.

Setting: Primary care practices and patient researchers at an academic centre in Southern Alberta. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024016DOI Listing
February 2019

Health Outcomes, Pathogenesis and Epidemiology of Severe Acute Malnutrition (HOPE-SAM): rationale and methods of a longitudinal observational study.

BMJ Open 2019 Feb 1;9(1):e023077. Epub 2019 Feb 1.

Blizard Institute, Queen Mary University of London, London, UK.

Introduction: Mortality among children hospitalised for complicated severe acute malnutrition (SAM) remains high despite the implementation of WHO guidelines, particularly in settings of high HIV prevalence. Children continue to be at high risk of morbidity, mortality and relapse after discharge from hospital although long-term outcomes are not well documented. Better understanding the pathogenesis of SAM and the factors associated with poor outcomes may inform new therapeutic interventions. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02307
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http://dx.doi.org/10.1136/bmjopen-2018-023077DOI Listing
February 2019
3 Reads

Temporal trends in neonatal mortality and morbidity following spontaneous and clinician-initiated preterm birth in Washington State, USA: a population-based study.

BMJ Open 2019 Feb 1;9(1):e023004. Epub 2019 Feb 1.

Department of Obstetrics and Gynaecology, University of British Columbia and the Children's and Women's Hospital and Health Centre of British Columbia, Vancouver, British Columbia, Canada.

Objective: After a decade of increase, the preterm birth (PTB) rate has declined in the USA since 2006, with the largest decline at late preterm (34-36 weeks). We described concomitant changes in gestational age-specific rates of neonatal mortality and morbidity following spontaneous and clinician-initiated PTB among singleton infants.

Design, Setting And Participants: This retrospective population-based study included 754 763 singleton births in Washington State, USA, 2004-2013, using data from birth certificates and hospitalisation records. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02300
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http://dx.doi.org/10.1136/bmjopen-2018-023004DOI Listing
February 2019
1 Read

The authors respond to comments on the use of secure care in youth.

CMAJ 2019 Feb;191(7):E199-E200

PhD student, Interdisciplinary Studies, Graduate Program, University of British, Columbia; Research Assistant, BC Centre, on Substance Use, Vancouver, BC.

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http://dx.doi.org/10.1503/cmaj.71589DOI Listing
February 2019

Secure care can help youth reduce imminent risk of serious harm and prevent unnecessary death.

CMAJ 2019 Feb;191(7):E197-E198

Division of Adolescent Health and Medicine, BC Children's Hospital, Vancouver, BC.

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http://dx.doi.org/10.1503/cmaj.71451DOI Listing
February 2019

An ethical perspective on the use of secure care for youth with severe substance use.

CMAJ 2019 Feb;191(7):E195-E196

Director, Clinical Ethics Service, Provincial, Health Services Authority of British, Columbia, Vancouver, BC.

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http://dx.doi.org/10.1503/cmaj.71504DOI Listing
February 2019

Ascites in a 21-year-old man.

CMAJ 2019 Feb;191(7):E188-E191

Family Medicine (Dhalla), University of British Columbia Coastal Program; Departments of Gastroenterology (Evaschesen), Infectious Disease (Connors), General Internal Medicine (Montis), Lions Gate Hospital, Vancouver, BC; Squamish General Hospital (Evaschesen), Squamish, BC; Department of Infectious Diseases (Connors), St. Paul's Hospital, and the British Columbia Center for Disease Control (Connors), Vancouver, BC.

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http://dx.doi.org/10.1503/cmaj.181072DOI Listing
February 2019

The safety of oral fluconazole therapy in pregnancy.

CMAJ 2019 Feb;191(7):E177-E178

Department of Pharmacy (Paquette), Department of Obstetrics and Gynecology (Elwood), British Columbia Women's Hospital and Health Centre; Department of Obstetrics and Gynecology (Elwood), University of British Columbia; Women's Health Research Institute (Elwood), Vancouver, BC.

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http://dx.doi.org/10.1503/cmaj.190079DOI Listing
February 2019

Developing a Clinical Pathway for Somatic Symptom and Related Disorders in Pediatric Hospital Settings.

Hosp Pediatr 2019 Feb 19. Epub 2019 Feb 19.

Department of Child and Adolescent Psychiatry, Ann and Robert H. Lurie Children's Hospital of Chicago and Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

Somatic symptom and related disorders (SSRDs) are commonly encountered in pediatric hospital settings. There is, however, a lack of standardization of care across institutions for youth with these disorders. These patients are diagnostically and psychosocially complex, posing significant challenges for medical and behavioral health care providers. Read More

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http://dx.doi.org/10.1542/hpeds.2018-0205DOI Listing
February 2019

The response to lymphodepletion impacts PFS in aggressive non-Hodgkin lymphoma patients treated with CD19 CAR-T cells.

Blood 2019 Feb 19. Epub 2019 Feb 19.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States.

Factors associated with durable remission after CD19 chimeric antigen receptor (CAR)-modified T cell immunotherapy for aggressive B-cell non-Hodgkin lymphoma (NHL) have not been identified. We report multivariable analyses of factors impacting response and progression-free survival (PFS) in aggressive NHL patients treated with cyclophosphamide and fludarabine (Cy/Flu) lymphodepletion followed by 2x10 CD19 CAR-T cells/kg. The best overall response rate (ORR) was 51%, with 40% of patients achieving complete remission (CR). Read More

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http://dx.doi.org/10.1182/blood-2018-11-887067DOI Listing
February 2019

Genetic drivers of oncogenic pathways in molecular subgroups of peripheral T-cell lymphoma.

Blood 2019 Feb 19. Epub 2019 Feb 19.

Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, United States;

Peripheral T-cell lymphoma (PTCL) is a group of complex clinicopathological entities, often associated with an aggressive clinical course. Angioimmunoblastic T-cell lymphoma (AITL) and PTCL-not otherwise specified (PTCL-NOS) are the two most frequent categories accounting for more than 50% of PTCLs. Gene expression profiling (GEP) defined molecular signatures for AITL and delineated biological and prognostic subgroups within PTCL-NOS (PTCL-GATA3 and PTCL-TBX21). Read More

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http://dx.doi.org/10.1182/blood-2018-09-872549DOI Listing
February 2019

Medical device-related pressure ulcers: A systematic review and meta-analysis.

Int J Nurs Stud 2019 Feb 10;92:109-120. Epub 2019 Feb 10.

Oxford Health NHS Foundation Trust, UK; Faculty of Health, Education and Life Sciences, Birmingham City University, UK.

Objective: To review observational studies reporting medical device-related pressure injuries and to identify the medical devices commonly associated with pressure injuries.

Design: A systematic review of primary research was undertaken, according to the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines.

Data Sources: A comprehensive electronic literature search of AMED, CINAHL, MEDLINE, PsycINFO, Web of Science, British Nursing Database and Google Scholar was conducted from inception to 31 December 2018. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00207489193003
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http://dx.doi.org/10.1016/j.ijnurstu.2019.02.006DOI Listing
February 2019
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Synthesis of contraries: Hughlings Jackson on sensory-motor representation in the brain.

Authors:
M Chirimuuta

Stud Hist Philos Biol Biomed Sci 2019 Feb 16. Epub 2019 Feb 16.

Dept. History & Philosophy of Science, 1101 Cathedral of Learning, 4200 Fifth Avenue, University of Pittsburgh, Pittsburgh, PA, 15260, USA. Electronic address:

This paper examines the concept of representation in the brain which occurs in the writings of the neurologist John Hughlings Jackson (1835-1911). Jackson was immersed in Victorian physiological psychology, a hybrid of British associationism and a reflex theory of the operation of the nervous system. Furthermore, Jackson was deeply influenced by Herbert Spencer, and I argue that Spencer's progressivist evolutionary ideas are in tension with the more mechanistic approach of the reflex theory. Read More

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http://dx.doi.org/10.1016/j.shpsc.2019.01.007DOI Listing
February 2019

Sclerotherapy for rectal prolapse in children: A systematic review and meta-analysis.

J Pediatr Surg 2019 Feb 3. Epub 2019 Feb 3.

Division of Pediatric Surgery, Department of Surgery, British Columbia Children's Hospital, Vancouver, BC, Canada. Electronic address:

Background: Sclerotherapy is a commonly utilized treatment for rectal prolapse in children. This study systematically evaluates the effectiveness and complications of various sclerosing agents in treating pediatric rectal prolapse.

Methods: After protocol registration (CRD-42018088980), multiple databases were searched. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.033DOI Listing
February 2019

Canadian Association of Pediatric Surgeons' state of wellness.

J Pediatr Surg 2019 Jan 31. Epub 2019 Jan 31.

Department of Surgery, University of Toronto, Toronto, ON, Canada.

The following is a summary of the fourth Ein Panel Debate Session from the 50th Annual Meeting of the Canadian Association of Pediatric Surgeons (CAPS) held in Toronto, ON, from September 26-29, 2018. The session focused on surgeon well-being at different stages of career: role of mentorship at the start of career, second victim syndrome, litigation stress syndrome, and retirement. Using Maslach Burnout Inventory Survey, CAPS members were presented their wellness scores as a group compared to other health care providers. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2019.01.014DOI Listing
January 2019

Lung Cancer Screening in Never-Smokers.

Authors:
Stephen Lam

J Thorac Oncol 2019 Mar;14(3):336-337

British Columbia Cancer and the University of British Columbia, Vancouver, British Columbia. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2018.12.019DOI Listing

Puccinia acroptili on Russian Knapweed in Colorado, Montana, and Wyoming.

Plant Dis 2006 Jul;90(7):971

USDA-ARS-SBML, Beltsville, MD 20705.

Acroptilon repens (L.) DC. (Russian knapweed) is a long-lived perennial weed from central Asia that is widely distributed in the western United States (U. Read More

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http://dx.doi.org/10.1094/PD-90-0971CDOI Listing

Laronidase for the treatment of mucopolysaccharidosis type I.

Authors:
Lorne A Clarke

Expert Rev Endocrinol Metab 2011 Nov;6(6):755-768

a Department of Medical Genetics, University of British Columbia, Child and Family Research Institute, 4500 Oak Street, RM C234, Vancouver, British Columbia, V6H-3N1, Canada.

A decade has passed since the initial report that parenteral use of recombinant human α-L-iduronidase results in amelioration of symptoms in patients with mucopolysaccharidosis type I (MPS I). As a result, MPS I became the first mucopolysaccharide storage disorder to benefit from enzyme replacement therapy (ERT); subsequent ERTs have been approved for MPS II and VI. The ability of lysosomal storage disorders to respond to ERT is unique among genetic disorders and relates to the capability of cells to take up recombinant lysosomal enzymes through cell surface receptors and deliver them to the lysosome, a processed coined as 'cross-correction'. Read More

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http://dx.doi.org/10.1586/eem.11.72DOI Listing
November 2011

First Report of the Root-Rot Pathogen, Armillaria nabsnona, from Hawaii.

Plant Dis 2007 May;91(5):634

USDA Forest Service, RMRS, Forestry Sciences Laboratory, 1221 South Main Street, Moscow, ID 83843.

The genus Armillaria (2) and Armillaria mellea sensu lato (3) have been reported previously from Hawaii. However, Armillaria species in Hawaii have not been previously identified by DNA sequences, compatibility tests, or other methods that distinguish currently recognized taxa. In August 2005, Armillaria rhizomorphs and mycelial bark fans were collected from two locations on the island of Hawaii. Read More

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http://dx.doi.org/10.1094/PDIS-91-5-0634BDOI Listing