161,762 results match your criteria British Journal Of Religious Education[Journal]


"Not Everybody's an Athlete, But They Certainly Can Move": Facilitators of Physical Activity Maintenance in Older Adults in a Northern and Rural Setting.

J Aging Phys Act 2020 Jun 4:1-10. Epub 2020 Jun 4.

Although the benefits of maintaining a physical activity regime for older adults are well known, it is unclear how programs and facilities can best support long-term participation. The purpose of this study is to determine the facilitating factors of physical activity maintenance in older adults at individual, program, and community levels. Nine semistructured interviews were conducted with individuals aged 60 years and older and long-term participants (>6 months) in community-based group exercise at a clinical wellness facility in northern British Columbia, Canada. Read More

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http://dx.doi.org/10.1123/japa.2019-0393DOI Listing

Pregnancy outcomes and postpartum relapse rates in women with RRMS treated with alemtuzumab in the phase 2 and 3 clinical development program over 16 years.

Mult Scler Relat Disord 2020 May 6;43:102146. Epub 2020 May 6.

University of Cambridge, Cambridge, United Kingdom. Electronic address:

Background: Relapsing-remitting multiple sclerosis (RRMS) is frequently diagnosed in women of reproductive age. Because the use of disease-modifying therapies (DMTs) early in the disease course is increasing, it is important to evaluate the safety of DMTs in pregnant women and their developing fetuses. Alemtuzumab, approved for the treatment of relapsing forms of MS, is administered as 2 courses of 12 mg/day on 5 consecutive days at baseline and on 3 consecutive days 12 months later. Read More

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http://dx.doi.org/10.1016/j.msard.2020.102146DOI Listing

Impact of COVID-19 pandemic on patients with ST-segment elevation myocardial infarction: Insights from a British cardiac center.

Am Heart J 2020 May 11;226:45-48. Epub 2020 May 11.

Division of Cardiology, Ain Shams University, Cairo, Egypt; Cardiovascular Institute, The Warren Alpert Medical School of Brown University and Lifespan Cardiovascular Institute, Providence, RI, USA. Electronic address:

The current study aimed to examine the impact of COVID-19 pandemic on patient-related delay with ST-segment elevation myocardial infarction (STEMI) at a tertiary center in the United Kingdom. The study demonstrated a significant delay in symptom-to-first medical contact and a higher cardiac troponin-I level on admission in patients with STEMI during the COVID-19 pandemic versus the pre-COVID era. Read More

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http://dx.doi.org/10.1016/j.ahj.2020.04.022DOI Listing

Cognitive markers of dementia risk in middle-aged women with bilateral salpingo-oophorectomy prior to menopause.

Neurobiol Aging 2020 Apr 29;94:1-6. Epub 2020 Apr 29.

Department of Psychology, University of Toronto, Toronto, Ontario, Canada; Rotman Research Institute, Toronto, Ontario, Canada; Tema Genus, Linköping University, Linköping, Sweden.

Oophorectomy prior to menopause is associated with late-life dementia. Memory decline may start within 6 months after oophorectomy in middle-aged women, suggested by lower verbal and working memory performance. Unknown is whether such changes persist beyond 6 months, and whether they are reversed by estradiol. Read More

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http://dx.doi.org/10.1016/j.neurobiolaging.2020.04.019DOI Listing

Postpartum fluoxetine increased maternal inflammatory signalling and decreased tryptophan metabolism: Clues for efficacy.

Neuropharmacology 2020 Jun 1:108174. Epub 2020 Jun 1.

Graduate Program in Neuroscience, University of British Columbia, Canada; Department of Psychology, University of British Columbia, Canada; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Canada. Electronic address:

Perinatal depression (PND) affects approximately 15% of women, and de novo postpartum depression affects approximately 40% of PND cases. Selective serotonin reuptake inhibitors (SSRIs) are a common class of antidepressants prescribed to treat PND. However, the safety and efficacy of SSRIs have been questioned in both clinical and preclinical research. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2020.108174DOI Listing

The effect of low-volume high-intensity interval training on cardiometabolic health and psychological responses in overweight/obese middle-aged men.

J Sports Sci 2020 Jun 4:1-8. Epub 2020 Jun 4.

Department of Sports Science and Physical Education, The Chinese University of Hong Kong , Shatin, Hong Kong.

High-intensity interval training (HIIT) has been proposed as a time-efficient exercise protocol to improve metabolic health, but direct comparisons with higher-volume moderate-intensity continuous training (MICT) under unsupervised settings are limited. This study compared low-volume HIIT and higher-volume MICT interventions on cardiometabolic and psychological responses in overweight/obese middle-aged men. Twenty-four participants (age: 48. Read More

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http://dx.doi.org/10.1080/02640414.2020.1766178DOI Listing

Receptor-like kinases MDS1 and MDS2 promote SUMM2-mediated immunity.

J Integr Plant Biol 2020 Jun 4. Epub 2020 Jun 4.

Department of Botany, University of British Columbia, Vancouver, BC, Canada.

Disruption of the MEKK1-MKK1/MKK2-MPK4 kinase cascade leads to activation of immunity mediated by the nucleotide-binding leucine-rich repeat (NLR) immune receptor SUMM2, which monitors the phosphorylation status of CRCK3. Here we report that two receptor-like kinases (RLKs), MDS1 and MDS2, function redundantly to promote SUMM2-mediated immunity. Activation of SUMM2-mediated immunity is dependent on MDS1, and to a less extent on MDS2. Read More

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http://dx.doi.org/10.1111/jipb.12978DOI Listing

In Reply: Modulation of Nigrofugal and Pallidofugal Pathways in Deep Brain Stimulation for Parkinson Disease.

Neurosurgery 2020 Jun 4. Epub 2020 Jun 4.

Department of Surgery Division of Neurosurgery University of British Columbia Vancouver, BC, Canada.

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http://dx.doi.org/10.1093/neuros/nyaa229DOI Listing

Health providers' readiness for electronic health records adoption: A cross-sectional study of two hospitals in northern Ghana.

PLoS One 2020 4;15(6):e0231569. Epub 2020 Jun 4.

Department of Occupational and Environmental Health, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Introduction: Electronic Health Records are receiving considerable attention as a valuable tool for managing clinical information. Despite the prospects of Electronic Health Records in developing countries, many pre-implementation assessments target organizational, managerial, and infrastructural readiness, but barely include a detailed examination of health provider readiness. Meanwhile, health provider readiness is a critical success factor for electronic health records in settings where the majority of the workforce is less likely to have basic computer skills. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231569PLOS

Estimating the population health impact of recently introduced modified risk tobacco products: a comparison of different approaches.

Nicotine Tob Res 2020 Jun 4. Epub 2020 Jun 4.

Philip Morris R&D, Philip Morris Products SA, Quai Jeanrenaud, Neuchâtel, Switzerland.

We review approaches used to estimate the population health impact of introducing a Modified Risk Tobacco Product (MRTP). Thirteen models are described, some focussing on e-cigarettes, others more general. Most models are cohort-based, comparing results with or without MRTP introduction. Read More

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http://dx.doi.org/10.1093/ntr/ntaa102DOI Listing

Hypnagogic Frontal EEG Bursts in Children: Epileptic or Not?

Authors:
Anita N Datta

J Clin Neurophysiol 2020 May 28. Epub 2020 May 28.

Division of Neurology, Department of Pediatrics, BC Children's Hospital, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada.

Purpose: Various EEG patterns emerge in drowsiness. Intermittent bilateral midfrontal slowing (BFS) and hypnogogic frontal predominant sharply contoured waveforms (HFSC), maximal at (Fz, F3-4, and Fp1-2), are often encountered. These do not meet the criteria for epileptiform discharges. Read More

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http://dx.doi.org/10.1097/WNP.0000000000000722DOI Listing

A baculoviral system for the production of human β-glucocerebrosidase enables atomic resolution analysis.

Acta Crystallogr D Struct Biol 2020 Jun 29;76(Pt 6):565-580. Epub 2020 May 29.

Department of Chemistry, York Structural Biology Laboratory, University of York, Heslington, York YO10 5DD, United Kingdom.

The lysosomal glycoside hydrolase β-glucocerebrosidase (GBA; sometimes called GBA1 or GC) catalyses the hydrolysis of glycosphingolipids. Inherited deficiencies in GBA cause the lysosomal storage disorder Gaucher disease (GD). Consequently, GBA is of considerable medical interest, with continuous advances in the development of inhibitors, chaperones and activity-based probes. Read More

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http://dx.doi.org/10.1107/S205979832000501XDOI Listing

Increased diversity and concordant shifts in community structure of coral-associated Symbiodiniaceae and bacteria subjected to chronic human disturbance.

Mol Ecol 2020 Jun 4. Epub 2020 Jun 4.

University of Victoria, Department of Biology, British Columbia, Canada.

Coral-associated bacteria and endosymbiotic algae (Symbiodiniaceae spp.) are both vitally important for the biological function of corals. Yet little is known about their co-occurrence within corals, how their diversity varies across coral species, or how they are impacted by anthropogenic disturbances. Read More

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http://dx.doi.org/10.1111/mec.15494DOI Listing

In vivo measures of anterior scleral resistance in humans with rebound tonometry.

Ophthalmic Physiol Opt 2020 Jun 3. Epub 2020 Jun 3.

School of Life & Health Sciences, Aston University, Birmingham, UK.

Purpose: To measure regional variations in anterior scleral resistance (ASR) using a ballistic rebound tonometer (RBT) and examine whether the variations are significantly affected by ethnicity and refractive error (RE).

Methods: ASR was measured using a RBT (iCare TA01) following calibration against the biomechanical properties of agarose biogels. Eight scleral regions (nasal, temporal, superior, inferior, inferior-nasal, inferior-temporal, superior-nasal and superior-temporal) were measured at locations 4mm from the limbus. Read More

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http://dx.doi.org/10.1111/opo.12695DOI Listing

Randomised controlled trial of multi-modular motion-assisted memory desensitisation and reconsolidation (3MDR) for male military veterans with treatment-resistant post-traumatic stress disorder.

Acta Psychiatr Scand 2020 Jun 3. Epub 2020 Jun 3.

Leiden University Medical Center, Leiden, Netherlands.

Objective: To explore the potential efficacy of multi-modular motion-assisted memory desensitisation and reprocessing (3MDR) in British military veterans with treatment-resistant, service-related PTSD.

Methods: Exploratory single-blind, randomised, parallel arm, cross-over controlled trial with nested process evaluation to assess fidelity, adherence and factors that influence outcome.

Results: 42 participants (all male) were randomised with 83% retention at 12 weeks and 86% at 26 weeks. Read More

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http://dx.doi.org/10.1111/acps.13200DOI Listing

Weight Loss After Bariatric Surgery Significantly Improves Carotid and Cardiac Function in Apparently Healthy People with Morbid Obesity.

Obes Surg 2020 Jun 3. Epub 2020 Jun 3.

Department of Mechanical and Aerospace Engineering, Brunel University London, Kingston Lane, Uxbridge, Middlesex, UB8 3PH, UK.

Purpose: Obesity clearly increases cardiovascular risk, often inducing high blood pressure (BP), impaired left ventricular (LV) function, and increased arterial stiffness. Intensive weight loss and bariatric surgery induce improvement in hypertension and diabetes for morbid obesity. Carotid artery haemodynamics is a powerful prognostic indicator for stroke and cognitive decline independent of BP. Read More

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http://dx.doi.org/10.1007/s11695-020-04686-yDOI Listing

Letter to the Editor: Cultural Barriers for Women in Surgery-How Thick is the Glass Ceiling? An Analysis from a Low-Middle-Income Country.

World J Surg 2020 Jun 3. Epub 2020 Jun 3.

Division of Cardiovascular Surgery, Department of Surgery, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1007/s00268-020-05624-wDOI Listing

Inflammation and salt in young adults: the African-PREDICT study.

Eur J Nutr 2020 Jun 3. Epub 2020 Jun 3.

Hypertension in Africa Research Team (HART), North-West University, Potchefstroom, South Africa.

Purpose: Low-grade inflammation and a diet high in salt are both established risk factors for cardiovascular disease. High potassium (K) intake was found to counter increase in blood pressure due to high salt intake and may potentially also have protective anti-inflammatory effects. To better understand these interactions under normal physiological conditions, we investigated the relationships between 22 inflammatory mediators with 24-h urinary K in young healthy adults stratified by low, medium and high salt intake (salt tertiles). Read More

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http://dx.doi.org/10.1007/s00394-020-02292-3DOI Listing

Nanofibrillar networks enable universal assembly of superstructured particle constructs.

Sci Adv 2020 May 8;6(19):eaaz7328. Epub 2020 May 8.

Department of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, FI-00076 Espoo, Finland.

Superstructured colloidal materials exploit the synergies between components to develop new or enhanced functions. Cohesion is a primary requirement for scaling up these assemblies into bulk materials, and it has only been fulfilled in case-specific bases. Here, we demonstrate that the topology of nanonetworks formed from cellulose nanofibrils (CNFs) enables robust superstructuring with virtually any particle. Read More

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http://dx.doi.org/10.1126/sciadv.aaz7328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209999PMC

Timing of the martian dynamo: New constraints for a core field 4.5 and 3.7 Ga ago.

Sci Adv 2020 May 1;6(18):eaba0513. Epub 2020 May 1.

Department of Earth and Planetary Sciences, and McDonnell Center for the Space Sciences, Washington University in St. Louis, St. Louis, MO 63130, USA.

The absence of crustal magnetic fields above the martian basins Hellas, Argyre, and Isidis is often interpreted as proof of an early, before 4.1 billion years (Ga) ago, or late, after 3.9 Ga ago, dynamo. Read More

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http://dx.doi.org/10.1126/sciadv.aba0513DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195189PMC

Road development in Asia: Assessing the range-wide risks to tigers.

Sci Adv 2020 May 29;6(18):eaaz9619. Epub 2020 Apr 29.

Department of Biology, University of British Columbia, Kelowna, BC, Canada.

Roads are proliferating worldwide at an unprecedented rate, with potentially severe impacts on wildlife. We calculated the extent and potential impacts of road networks across the 1,160,000-km, 13-country range of the globally endangered tiger ()-a conservation umbrella species. We found that roads were pervasive, totaling 134,000 km across tiger conservation landscapes (TCLs), even in tiger priority sites and protected areas. Read More

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http://dx.doi.org/10.1126/sciadv.aaz9619DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190336PMC

Sperm DNA damage causes genomic instability in early embryonic development.

Sci Adv 2020 Apr 15;6(16):eaaz7602. Epub 2020 Apr 15.

Center for Molecular Medicine and Oncode Institute, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, Utrecht 3584 CG, Netherlands.

Genomic instability is common in human embryos, but the underlying causes are largely unknown. Here, we examined the consequences of sperm DNA damage on the embryonic genome by single-cell whole-genome sequencing of individual blastomeres from bovine embryos produced with sperm damaged by γ-radiation. Sperm DNA damage primarily leads to fragmentation of the paternal chromosomes followed by random distribution of the chromosomal fragments over the two sister cells in the first cell division. Read More

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http://dx.doi.org/10.1126/sciadv.aaz7602DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159919PMC

Clues beyond the lung: an unusual diagnosis in an infant with chronic lung disease.

Breathe (Sheff) 2020 Mar;16(1):190319

Paediatric Respiratory Medicine, Nottingham University Hospitals NHS Trust, Nottingham, UK.

http://bit.ly/2webytn. Read More

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http://dx.doi.org/10.1183/20734735.0319-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249791PMC

Pranlukast Antagonizes CD49f and Reduces Stemness in Triple-Negative Breast Cancer Cells.

Drug Des Devel Ther 2020 12;14:1799-1811. Epub 2020 May 12.

Department of Pharmacology, School of Medicine, Universidad Nacional Autónoma de México, Mexico City, Mexico.

Introduction: Cancer stem cells (CSCs) drive the initiation, maintenance, and therapy response of breast tumors. CD49f is expressed in breast CSCs and functions in the maintenance of stemness. Thus, blockade of CD49f is a potential therapeutic approach for targeting breast CSCs. Read More

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http://dx.doi.org/10.2147/DDDT.S247730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229803PMC

RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro.

Nat Commun 2020 Jun 3;11(1):2797. Epub 2020 Jun 3.

Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 7LE, UK.

Fat distribution is an independent cardiometabolic risk factor. However, its molecular and cellular underpinnings remain obscure. Here we demonstrate that two independent GWAS signals at RSPO3, which are associated with increased body mass index-adjusted waist-to-hip ratio, act to specifically increase RSPO3 expression in subcutaneous adipocytes. Read More

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http://dx.doi.org/10.1038/s41467-020-16592-zDOI Listing

Assessing distribution shifts and ecophysiological characteristics of the only Antarctic winged midge under climate change scenarios.

Sci Rep 2020 Jun 3;10(1):9087. Epub 2020 Jun 3.

British Antarctic Survey, Cambridge, UK.

Parts of Antarctica were amongst the most rapidly changing regions of the planet during the second half of the Twentieth Century. Even so, today, most of Antarctica remains in the grip of continental ice sheets, with only about 0.2% of its overall area being ice-free. Read More

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http://dx.doi.org/10.1038/s41598-020-65571-3DOI Listing

Guidance for otolaryngology health care workers performing aerosol generating medical procedures during the COVID-19 pandemic.

J Otolaryngol Head Neck Surg 2020 Jun 3;49(1):36. Epub 2020 Jun 3.

BC Rotary Hearing and Balance Centre at St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for Coronavirus disease 2019 (COVID-19) has a predilection for infecting the mucosa of the upper and lower airways. Otolaryngologists and supporting health care workers (HCWs) are particularly at high risk of becoming infected while treating patients as many in-office procedures and surgeries are Aerosol Generating Medical Procedures (AGMP). Based on a review of the literature and various guidelines, recommendations are made to mitigate the risk to health care workers of becoming infected with SARS-CoV-2 while providing clinical care. Read More

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http://dx.doi.org/10.1186/s40463-020-00429-2DOI Listing

The role of testosterone in chronic kidney disease and kidney function in men and women: a bi-directional Mendelian randomization study in the UK Biobank.

BMC Med 2020 Jun 4;18(1):122. Epub 2020 Jun 4.

School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 1/F, Patrick Manson Building, 7 Sassoon Road, Pokfulam, Hong Kong SAR, China.

Background: Chronic kidney disease (CKD) has an apparent sex disparity, with a more rapid progress in men than in women. Whether the well-established sex-specific evolutionary biology trade-off between reproduction and longevity might inform CKD has not previously been considered. Relevant evidence from randomized controlled trials (RCTs) is not available. Read More

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http://dx.doi.org/10.1186/s12916-020-01594-xDOI Listing

MAUDE: inferring expression changes in sorting-based CRISPR screens.

Genome Biol 2020 Jun 3;21(1):134. Epub 2020 Jun 3.

Klarman Cell Observatory, Broad Institute of MIT and Harvard University, Cambridge, MA, 02142, USA.

Improved methods are needed to model CRISPR screen data for interrogation of genetic elements that alter reporter gene expression readout. We create MAUDE (Mean Alterations Using Discrete Expression) for quantifying the impact of guide RNAs on a target gene's expression in a pooled, sorting-based expression screen. MAUDE quantifies guide-level effects by modeling the distribution of cells across sorting expression bins. Read More

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http://dx.doi.org/10.1186/s13059-020-02046-8DOI Listing

Smart triage: triage and management of sepsis in children using the point-of-care Pediatric Rapid Sepsis Trigger (PRST) tool.

BMC Health Serv Res 2020 Jun 3;20(1):493. Epub 2020 Jun 3.

Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, 217-2176 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada.

Background: Sepsis is the leading cause of death and disability in children. Every hour of delay in treatment is associated with an escalating risk of morbidity and mortality. The burden of sepsis is greatest in low- and middle-income countries where timely treatment may not occur due to delays in diagnosis and prioritization of critically ill children. Read More

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http://dx.doi.org/10.1186/s12913-020-05344-wDOI Listing

Distinctions between sex and time in patterns of DNA methylation across puberty.

BMC Genomics 2020 Jun 3;21(1):389. Epub 2020 Jun 3.

Department of Psychology, Stanford University, 450 Jane Stanford Way, Stanford, CA, 94305, USA.

Background: There are significant sex differences in human physiology and disease; the genomic sources of these differences, however, are not well understood. During puberty, a drastic neuroendocrine shift signals physical changes resulting in robust sex differences in human physiology. Here, we explore how shifting patterns of DNA methylation may inform these pathways of biological plasticity during the pubertal transition. Read More

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http://dx.doi.org/10.1186/s12864-020-06789-3DOI Listing

Meta-Analytic Use of Balanced Identity Theory to Validate the Implicit Association Test.

Pers Soc Psychol Bull 2020 Jun 4:146167220916631. Epub 2020 Jun 4.

University of Washington, Seattle, USA.

This meta-analysis evaluated theoretical predictions from balanced identity theory (BIT) and evaluated the validity of zero points of Implicit Association Test (IAT) and self-report measures used to test these predictions. Twenty-one researchers contributed individual subject data from 36 experiments (total = 12,773) that used both explicit and implicit measures of the social-cognitive constructs. The meta-analysis confirmed predictions of BIT's balance-congruity principle and simultaneously validated interpretation of the IAT's zero point as indicating absence of preference between two attitude objects. Read More

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http://dx.doi.org/10.1177/0146167220916631DOI Listing

'Choice' in occupational therapy theory: A critique from the situation of patriarchy in India.

Scand J Occup Ther 2020 Jun 4:1-12. Epub 2020 Jun 4.

Faculty of Medicine, Department of Occupational Science and Occupational Therapy, University of British Columbia, Vancouver, Canada.

Dominant occupational therapy theories assert that people choose their daily occupations, and participate in occupations as autonomous agents; yet scholars insist that choices are socially-structured and inequitably available. To critically review the concept of choice in occupational therapy theory through an exploration of patriarchy in India. Drawing from scholarly work that addresses patriarchy in India, we employ the commonly-used occupational categories of self-care, productivity and leisure as a framework to explore the real availability of occupational choices for women. Read More

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http://dx.doi.org/10.1080/11038128.2020.1769182DOI Listing

Impact of Transcatheter Aortic Valve Durability on Life Expectancy in Low Risk Patients with Severe Aortic Stenosis.

Circulation 2020 Jun 4. Epub 2020 Jun 4.

Division of Cardiac Surgery, Department of Surgery, Schulich Heart Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.

Recent clinical trial results showed that transcatheter aortic valve replacement (TAVR) is non-inferior and may be superior to surgical aortic valve replacement (SAVR) for mortality, stroke, and rehospitalization. However, the impact of transcatheter valve durability remains uncertain. Discrete event simulation (DES) was used to model hypothetical scenarios of TAVR versus SAVR durability where TAVR failure times were varied to determine the impact of TAVR valve durability on life-expectancy in a cohort of low risk patients similar to those in recent trials. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.119.044559DOI Listing

Moderate-intensity exercise and high-intensity interval training affect insulin sensitivity similarly in obese adults.

J Clin Endocrinol Metab 2020 Jun 3. Epub 2020 Jun 3.

Substrate Metabolism Laboratory, School of Kinesiology, University of Michigan, USA.

Objective: We compared the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on insulin sensitivity and other important metabolic adaptations in adults with obesity.

Methods: Thirty-one inactive adults with obesity (age: 31±6 years, BMI: 33±3 kg/m2) completed 12 weeks (4 sessions/week) of either HIIT (10x1-minute at 90%HRmax, 1-minute active recovery; n=16) or MICT (45 minutes at 70%HRmax; n=15). To assess the direct effects of exercise independent of weight/fat loss, participants were required to maintain body mass. Read More

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http://dx.doi.org/10.1210/clinem/dgaa345DOI Listing

Digest.

J Sport Exerc Psychol 2020 Jun 3:1-4. Epub 2020 Jun 3.

California State University, Fullerton, USA.

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http://dx.doi.org/10.1123/jsep.2020-0091DOI Listing

The association between obesity and poor outcome after COVID-19 indicates a potential therapeutic role for montelukast.

Med Hypotheses 2020 May 27;143:109883. Epub 2020 May 27.

President British Obesity and Metabolic Surgery Society, Visiting Professor University of Chester, CEO Phoenix Health, United Kingdom. Electronic address:

It is widely believed that infection with the SARS-CoV-2 virus triggers a disproportionate immune response which causes a devastating systemic injury, particularly in individuals with obesity, itself a chronic, multi-organ inflammatory disease. Immune cells accumulate in visceral adipose tissue and together with paracrine adipocytes release a wide range of biologically active cytokines (including IL-1β, IL5, IL6 and IL8) that can result in both local, pulmonary and systemic inflammation. A more intense 'cytokine storm' is postulated as the mechanism behind the extreme immune response seen in severe COVID-19. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.109883DOI Listing

Multiple Sequence Variants in STAC3 Affect Interactions with Ca1.1 and Excitation-Contraction Coupling.

Structure 2020 May 27. Epub 2020 May 27.

Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address:

STAC3 is a soluble protein essential for skeletal muscle excitation-contraction (EC) coupling. Through its tandem SH3 domains, it interacts with the cytosolic II-III loop of the skeletal muscle voltage-gated calcium channel. STAC3 is the target for a mutation (W284S) that causes Native American myopathy, but multiple other sequence variants have been reported. Read More

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http://dx.doi.org/10.1016/j.str.2020.05.005DOI Listing

Exercise Electrocardiography and Computed Tomography Coronary Angiography for Patients With Suspected Stable Angina Pectoris: A Post Hoc Analysis of the Randomized SCOT-HEART Trial.

JAMA Cardiol 2020 Jun 3. Epub 2020 Jun 3.

British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.

Importance: Recent European guidance supports a diminished role for exercise electrocardiography (ECG) in the assessment of suspected stable angina.

Objective: To evaluate the utility of exercise ECG in contemporary practice and assess the value of combined functional and anatomical testing.

Design, Setting, And Participants: This is a post hoc analysis of the Scottish Computed Tomography of the Heart (SCOT-HEART) open-label randomized clinical trial, conducted in 12 cardiology chest pain clinics across Scotland for patients with suspected angina secondary to coronary heart disease. Read More

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http://dx.doi.org/10.1001/jamacardio.2020.1567DOI Listing

HIV-1 variants are archived throughout infection and persist in the reservoir.

PLoS Pathog 2020 Jun 3;16(6):e1008378. Epub 2020 Jun 3.

Emory Vaccine Center, Emory University, Atlanta, Georgia, United States of America.

The HIV-1 reservoir consists of latently infected cells that persist despite antiretroviral therapy (ART). Elucidating the proviral genetic composition of the reservoir, particularly in the context of pre-therapy viral diversity, is therefore important to understanding reservoir formation and the persistence of latently infected cells. Here we investigate reservoir proviral variants from 13 Zambian acutely-infected individuals with additional pre-therapy sampling for a unique comparison to the ART-naïve quasispecies. Read More

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http://dx.doi.org/10.1371/journal.ppat.1008378DOI Listing

Examining the impact of the Respect in Sport Parent Program on the psychosocial experiences of minor hockey athletes.

J Sports Sci 2020 Jun 3:1-11. Epub 2020 Jun 3.

Faculty of Kinesiology and Physical Education, University of Toronto , Toronto, Canada.

Models of positive youth development suggest that athletes may be influenced by parent education programmes; however, there is little research examining the impact of such programmes on athlete outcomes. This study examined the impact of the Respect in Sport Parent Program on athlete outcomes among minor hockey players over three years. This study consisted of cross-sectional and longitudinal online surveys measuring athletes' positive and negative developmental experiences, prosocial and antisocial behaviours, parental support and pressure, and sport enjoyment and commitment. Read More

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http://dx.doi.org/10.1080/02640414.2020.1767839DOI Listing

Documenting change with the Canadian Occupational Performance Measure for children with cerebral palsy.

Dev Med Child Neurol 2020 Jun 3. Epub 2020 Jun 3.

Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, Toronto, ON, Canada.

Aim: To assess the Canadian Occupational Performance Measure's (COPM) ability to document change over 3 years in children with cerebral palsy (CP).

Method: This was a prospective study with ambulatory children with CP, aged 2 to 6 years. Caregivers set one to three COPM goals which were rescored annually over 3 years. Read More

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http://dx.doi.org/10.1111/dmcn.14569DOI Listing

Mitochondrial ion channels as targets for cardioprotection.

J Cell Mol Med 2020 Jun 3. Epub 2020 Jun 3.

Department of Biomedical Sciences, University of Padova, Padova, Italy.

Acute myocardial infarction (AMI) and the heart failure (HF) that often result remain the leading causes of death and disability worldwide. As such, new therapeutic targets need to be discovered to protect the myocardium against acute ischaemia/reperfusion (I/R) injury in order to reduce myocardial infarct (MI) size, preserve left ventricular function and prevent the onset of HF. Mitochondrial dysfunction during acute I/R injury is a critical determinant of cell death following AMI, and therefore, ion channels in the inner mitochondrial membrane, which are known to influence cell death and survival, provide potential therapeutic targets for cardioprotection. Read More

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http://dx.doi.org/10.1111/jcmm.15341DOI Listing

Ammonia Thermal Treatment toward Topological Defects in Porous Carbon for Enhanced Carbon Dioxide Electroreduction.

Adv Mater 2020 Jun 3:e2001300. Epub 2020 Jun 3.

Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, P. R. China.

Topological defects, with an asymmetric local electronic redistribution, are expected to locally tune the intrinsic catalytic activity of carbon materials. However, it is still challenging to deliberately create high-density homogeneous topological defects in carbon networks due to the high formation energy. Toward this end, an efficient NH thermal-treatment strategy is presented for thoroughly removing pyrrolic-N and pyridinic-N dopants from N-enriched porous carbon particles, to create high-density topological defects. Read More

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http://dx.doi.org/10.1002/adma.202001300DOI Listing

Evaluation of a Novel Protocol for Assessment and Treatment of Alcohol Withdrawal Syndrome in Psychiatric Inpatients.

Am J Addict 2020 Jun 3. Epub 2020 Jun 3.

Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada.

Background And Objectives: Despite the high incidence of alcohol withdrawal syndrome (AWS) in psychiatric inpatients, standardized methods for assessing and treating AWS have been studied only once before in this population. We evaluated a novel AWS assessment and treatment protocol designed for psychiatric inpatients.

Methods: This retrospective cohort study evaluated outcomes before and after implementation of the protocol. Read More

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http://dx.doi.org/10.1111/ajad.13058DOI Listing

The evolution of virtual reality in shoulder and elbow surgery.

JSES Int 2020 Jun 7;4(2):215-223. Epub 2020 May 7.

Department of Orthopaedics, University of British Columbia, Vancouver, BC, Canada.

Virtual Reality (VR) in orthopedic surgery has significantly increased in popularity in the areas of preoperative planning, intraoperative usage, and for education and training; however, its utilization lags behind other surgical disciplines and industries. The use of VR in orthopedics is largely focused on education and is currently endorsed by North American and European training committees. The use of VR in shoulder and elbow surgery has varying levels of evidence, from I to IV, and typically involves educational randomized controlled trials. Read More

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http://dx.doi.org/10.1016/j.jseint.2020.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256885PMC

How the World's Children Hear: A Narrative Review of School Hearing Screening Programs Globally.

OTO Open 2020 Apr-Jun;4(2):2473974X20923580. Epub 2020 May 19.

Department of Head and Neck Surgery and Communication Sciences, School of Medicine, Duke University, Durham, North Carolina, USA.

Objective: School hearing screening may mitigate the effects of childhood hearing loss through early identification and intervention. This study provides an overview of existing school hearing screening programs around the world, identifies gaps in the literature, and develops priorities for future research.

Data Sources: A structured search of the PubMed, Embase, and Cochrane Library databases. Read More

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http://dx.doi.org/10.1177/2473974X20923580DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238315PMC

Impact of an Open Access Nationwide Treatment Model on Hepatitis C Virus Antiviral Drug Resistance.

Hepatol Commun 2020 Jun 6;4(6):904-915. Epub 2020 Apr 6.

Storr Liver Centre The Westmead Institute for Medical Research The University of Sydney and Westmead Hospital Sydney Australia.

Direct acting antivirals (DAAs) have revolutionized hepatitis C virus (HCV) treatment, but drug resistance could undermine proposed global elimination targets. Real-world studies are needed to inform the impact of widespread DAA treatment on antiviral resistance in the community. The prevalence and range of posttreatment resistance-associated substitutions (RASs) was determined in Australian patients with open access to DAAs through a wide range of prescribers. Read More

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http://dx.doi.org/10.1002/hep4.1496DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262285PMC