5,418 results match your criteria British Journal Of Oral & Maxillofacial Surgery[Journal]


Use of Bisphosphonates and Other Bone Supportive Agents in the Management of Prostate Cancer - A UK Perspective.

Int J Clin Pract 2020 Jul 12:e13611. Epub 2020 Jul 12.

Queen's University Belfast, The Northern Ireland Cancer Centre, Belfast, Northern Ireland, UK.

Aim: To explore the practice and views of uro-oncologists in the UK regarding their use of bone supportive agents in patients with prostate cancer.

Methods: An expert-devised online questionnaire was completed by members of the British Uro-oncology Group (BUG).

Results: Of 160 uro-oncologists invited, 81 completed the questionnaire. Read More

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http://dx.doi.org/10.1111/ijcp.13611DOI Listing

Mandibular undifferentiated pleomorphic sarcoma: Molecular analysis of a primary cell population.

Clin Exp Dent Res 2020 Jul 11. Epub 2020 Jul 11.

Oral and Maxillofacial Surgery, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Background: Undifferentiated pleomorphic sarcomas are one of the most common subtypes of soft tissue sarcomas. These are aggressive mesenchymal tumors and are devoid of the major known biomarkers except vimentin. Our objective was to establish and characterize a primary cell population from a mandibular UPS specimen. Read More

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http://dx.doi.org/10.1002/cre2.301DOI Listing

Protective Effects of morin against depressive-like behavior prompted by chronic unpredictable mild stress in rats: Possible role of inflammasome-related pathways.

Biochem Pharmacol 2020 Jul 8:114140. Epub 2020 Jul 8.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Depression is a common mental illness that possesses a noteworthy effect on patients' lives. Many theories are recently studied for their plausible involvement in depression pathogenesis, especially oxidative stress and inflammation. Morin (2',3,4',5,7-pentahydroxyflavone), a natural flavonoid, is characterized by its potent anti-inflammatory, and anti-oxidant activities. Read More

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http://dx.doi.org/10.1016/j.bcp.2020.114140DOI Listing

GRaded oral challenge for Drug allergy Evaluation - Delabelling described through families' voices.

Clin Exp Allergy 2020 Jul 10. Epub 2020 Jul 10.

Department of Pediatrics and Child Health, The University of Manitoba, Winnipeg, Canada.

Background: Children are often diagnosed with an antibiotic allergy, with little investigation to confirm if it is a true allergy. Recent studies support the use of oral challenges to confirm antibiotic allergy. Yet, little is known about families' perceptions of these challenges, or experiences of living with a misdiagnosis, often for many years. Read More

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http://dx.doi.org/10.1111/cea.13707DOI Listing

Effects of curing modes on depth of cure and microtensile bond strength of bulk fill composites to dentin.

J Appl Oral Sci 2020 3;28:e20190753. Epub 2020 Jul 3.

Department of Oral Health Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, Canada.

Objectives To compare the microtensile bond strength (µTBS) and depth of cure (DOC) of bulk-fill composites cured by monowave (MW) and polywave (PW) LED units using different curing times. Methodology Three composites were tested: Tetric EvoCeram Bulk Fill (TBF), Filtek Bulk Fill (FBF), and Tetric EvoCeram (T; control). Flat dentin surfaces treated with adhesive (AdheSE Universal®, Ivoclar Vivadent) were bonded with 4 mm cylindrical samples of each bulk-fill composite material (n=6) and cured with monowave (Satelec) or polywave (Bluephase Style) curing units for 10 or 20 seconds. Read More

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http://dx.doi.org/10.1590/1678-7757-2019-0753DOI Listing

Infection risk of dermatologic therapeutics during the COVID-19 pandemic: an evidence-based recalibration.

Int J Dermatol 2020 Jul 3. Epub 2020 Jul 3.

Division of Dermatology, University of Ottawa, Ottawa, ON, Canada.

Recommendations were made recently to limit or stop the use of oral and systemic immunotherapies for skin diseases due to potential risks to the patients during the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) COVID-19 pandemic. Herein, we attempt to identify potentially safe immunotherapies that may be used in the treatment of cutaneous diseases during the current COVID-19 pandemic. We performed a literature review to approximate the risk of SARS-CoV-2 infection, including available data on the roles of relevant cytokines, cell subsets, and their mediators in eliciting an optimal immune response against respiratory viruses in murine gene deletion models and humans with congenital deficiencies were reviewed for viral infections risk and if possible coronaviruses specifically. Read More

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http://dx.doi.org/10.1111/ijd.15028DOI Listing

Making Sense of the Hands and Mouth: The Role of "Secondary" Cues to Meaning in British Sign Language and English.

Cogn Sci 2020 Jul;44(7):e12868

Division of Psychology and Language Sciences, University College London.

Successful face-to-face communication involves multiple channels, notably hand gestures in addition to speech for spoken language, and mouth patterns in addition to manual signs for sign language. In four experiments, we assess the extent to which comprehenders of British Sign Language (BSL) and English rely, respectively, on cues from the hands and the mouth in accessing meaning. We created congruent and incongruent combinations of BSL manual signs and mouthings and English speech and gesture by video manipulation and asked participants to carry out a picture-matching task. Read More

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http://dx.doi.org/10.1111/cogs.12868DOI Listing

Prolonged deployed hospital care in the management of military eye injuries.

Eye (Lond) 2020 Jul 2. Epub 2020 Jul 2.

Department of Ophthalmology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.

Background/objectives: Prolonged hospital care is described as deployed medical care, applied beyond doctrinal planning timelines and military medical planning envisages that in future conflicts, patients will have to be managed for up to 5 days without evacuation to their home country. We aimed to investigate the effect of prolonged hospital care on visual outcomes in the management of open and closed globe injures.

Methods: We conducted a retrospective cohort study in the setting of British military operations in Afghanistan. Read More

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http://dx.doi.org/10.1038/s41433-020-1070-2DOI Listing

Persistence and adherence to parenteral osteoporosis therapies: a systematic review.

Osteoporos Int 2020 Jul 1. Epub 2020 Jul 1.

Department of Medicine, Division of Rheumatology, University of Alberta, 8-130 Clinical Sciences Building, 11350 83rd Avenue NW, Edmonton, AB, T6G 2G3, Canada.

Osteoporosis is a chronic disease of low bone mass and fragility. Treatment is frequently compromised by suboptimal medication compliance causing increased morbidity. This review investigates adherence and persistence to parenteral osteoporosis therapies. Read More

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http://dx.doi.org/10.1007/s00198-020-05507-9DOI Listing

Training prostate cancer survivors and caregivers to be peer navigators: a blended online/in-person competency-based training program.

Support Care Cancer 2020 Jul 2. Epub 2020 Jul 2.

Division of Health Services and Policy, School of Population and Public Health, University of British Columbia, Vancouver, Canada.

Purpose: Cancer navigation improves access to support and reduces barriers to care; however, appropriate training of navigators is essential. We developed the TrueNTH Peer Navigation Training Program (PNTP), a competency-based, blended online/in-person course. In this study, we evaluate the feasibility, acceptability, and effectiveness of the PNTP among prostate cancer (PC) survivors (patients, caregivers). Read More

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http://dx.doi.org/10.1007/s00520-020-05586-8DOI Listing

Minimal manifestation status and prednisone withdrawal in the MGTX trial.

Neurology 2020 Jul 1. Epub 2020 Jul 1.

From the Department of Neurology, University of Alabama at Birmingham, Birmingham (I.L.); the Department of Biostatistics, University of Alabama at Birmingham, Birmingham (H.-C.K., I.B.A., G.R.C., T.M., G.M); the Department of Neurology, George Washington University School of Medicine and Health Sciences, Washington, DC (H.J.K.); the Department of Neurology, Greater Manchester Neuroscience Center, Salford, Greater Manchester, UK (J.S.); the Institute of Pathology, University Medical Center Göttingen, Göttingen (P.S.); the Department of Neurology, McGill University, Montreal (C.H.C.), and the Division of Neurology, University of British Columbia, Vancouver (J. Oger) - both in Canada; the Department of Neurology, University of Chile, Santiago (G.C.); the Division of Neurology, Department of Medicine, University of Cape Town, Cape Town, South Africa (J.M.H.); the Department of Neurosciences, Mental Health and Sensory Organs, Sapienza University of Rome (G.A.), the Department of Neurology, Catholic University, (A.E.) - both in Rome; the Department of Neurology, Johannes Gutenberg University, Mainz, Germany (W.N.); the Department of Neurology, University of Rochester Medical Center, Rochester, New York (E.C.); the Division of Neurology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand (R.W.); the Department of Neurology, Royal Melbourne Hospital, Victoria, Australia (J.O.K.); the Department of Neurology, University of Southern California, Los Angeles (S.R.B.), and the Department of Neurology, University of California Irvine Medical Center, Orange (T.M.) - both in California; the Department of Neurology, Medical College of Wisconsin, Milwaukee (A.C.B.); the Department of Neurology, Harvard Medical School, Boston (A.A.A.); Nerve and Muscle Center of Texas, Houston (A.I.S.), and the Department of Neurology, University of Texas Health Science Center, San Antonio (C.E.J.) - both in Texas; the Department of Neurology, Case Western Reserve University, Cleveland (B.K.), and the Department of Neurology, Ohio State University Wexner Medical Center, Columbus (J.T.K.) - both in Ohio; Walton Centre for Neurology and Neurosurgery, Liverpool (B.R.F.L.), and Nuffield Department of Clinical Neurosciences, Oxford University, Oxford (C.B., A.V.) - both in the United Kingdom; Unit of Neurology, University of Brasilia, Brasilia (E.D.-T.), the Department of Neurology, Federal University, Rio de Janeiro (M.W.-C.), and the Department of Neurology, Universidade Federal do Parana, Curitiba (L.C.W.) - all in Brazil; the Department of Neurology, Kanazawa University, Kanazawa, Japan (H.Y.); the Department of Neurology, University of Florida, Jacksonville (M.T.P.), and the Department of Neurology, University of Miami, Miami (M.B.) - both in Florida; the Department of Neurology, Augusta University, Augusta (M.H.R.); the Department of Neurology, Medical University of Warsaw, Warsaw, Poland (A.K.-P.); the Department of Neurology, Indiana School of Medicine, Indianapolis (R.M.P.); the Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands (J.J.G.M.V.); the Department of Neurology, Duke University Medical Center, Durham, NC (J.M.M.); the Department of Neurology, University of Kansas Medical Center, Kansas City (R.J.B.); the Department of Neurological Sciences, University of Vermont College of Medicine, Burlington (R.T.); the Division of Extramural Research, National Institutes of Health, National Institute of Neurological Disorders and Stroke, Bethesda, MD (R.C.); the Section of General Thoracic Surgery, Columbia University Medical Center, New York (J.R.S.); the Department of Neurology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo (G.I.W.).

Objective: To examine whether sustained minimal manifestation status (MMS) with complete withdrawal of prednisone is better achieved in thymectomized myasthenia gravis (MG) patients.

Methods: This study is a post hoc analysis of data from the randomized trial of thymectomy in myasthenia gravis (MGTX). MGTX was a multicenter, randomized, rater-blinded 3-year trial that was followed by a voluntary 2-year extension for patients with acetylcholine receptor (AChR) antibody positive MG without thymoma. Read More

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http://dx.doi.org/10.1212/WNL.0000000000010031DOI Listing

Management of Fracture Risk in Patients with Chronic Obstructive Pulmonary Disease (COPD): Building a UK Consensus Through Healthcare Professional and Patient Engagement.

Int J Chron Obstruct Pulmon Dis 2020 15;15:1377-1390. Epub 2020 Jun 15.

NIHR Nottingham BRC Respiratory Theme, School of Medicine, University of Nottingham, City Hospital Campus, Nottingham, UK.

Introduction: Osteoporosis and bone fractures are common in chronic obstructive pulmonary disease (COPD) and contribute significantly to morbidity and mortality. Current national guidance on COPD management recommends addressing bone health in patients, however, does not detail how. This consensus outlines key elements of a structured approach to managing bone health and fracture risk in patients with COPD. Read More

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http://dx.doi.org/10.2147/COPD.S233398DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311204PMC

Can Extended-release Injectable Medications Help Curb United States and Canada's Opioid Overdose Epidemic?

J Addict Med 2020 Jun 18. Epub 2020 Jun 18.

British Columbia Centre on Substance Use, Vancouver, BC, Canada (MES, SN); Department of Medicine, University of British Columbia, Vancouver, BC, Canada (MES, SN).

: Settings throughout the United States and Canada continue to face escalating overdose epidemics. Notably, history of overdose is associated with increased risk of fatal overdose. Unfortunately, despite frequent contact with health services and the well-known mortality benefits of medications for opioid use disorder (MOUD), only a fraction of overdose survivors is successfully linked to addiction care after leaving the emergency department. Read More

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http://dx.doi.org/10.1097/ADM.0000000000000697DOI Listing

Intra-articular infiltration analgesia for arthroscopic shoulder surgery: a systematic review and meta-analysis.

Anaesthesia 2020 Jun 29. Epub 2020 Jun 29.

Department of Anesthesiology and Pain Medicine, University of Toronto, Canada.

Phrenic-sparing analgesic techniques for shoulder surgery are desirable. Intra-articular infiltration analgesia is one promising phrenic-sparing modality, but its role remains unclear because of conflicting evidence of analgesic efficacy and theoretical concerns regarding chondrotoxicity. This systematic review and meta-analysis evaluated the benefits and risks of intra-articular infiltration in arthroscopic shoulder surgery compared with systemic analgesia or interscalene brachial plexus block. Read More

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http://dx.doi.org/10.1111/anae.15172DOI Listing

Could we have prevented all this? A comparison of the British and South Korean primary dental care response to COVID-19.

Br Dent J 2020 Jun;228(12):916-918

Specialist Registrar, Clinical Radiology, UK.

To limit the spread of the novel coronavirus (COVID-19), Britain enforced a strict national lockdown, which is affecting the lives of millions, including dental professionals. As a result, all routine dental work has been suspended and general dental practitioners (GDPs) are inevitably faced with financial difficulties, as well as an impending strain on dental services once the lockdown is lifted. In contrast, South Korea (SK) has effectively managed to keep the virus at bay without a lockdown and continues to deliver routine dental care throughout this period. Read More

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http://dx.doi.org/10.1038/s41415-020-1705-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319222PMC

Exploring residential care aide experiences with oral malodour in long-term care.

Nurs Open 2020 Jul 12;7(4):1208-1216. Epub 2020 May 12.

Department of Oral Biological and Medical Sciences Faculty of Dentistry The University of British Columbia Vancouver BC Canada.

Aim: To determine what experiences do residential care aides (RCAs) have with individuals living with oral malodour in a long-term care (LTC) facility?

Design: Study investigation was done using an interpretive qualitative approach paired with a social constructivism interpretive framework.

Methods: The study was conducted in May of 2015 through face-to-face interviews with RCAs, which were recorded and transcribed verbatim, observations of RCAs in their work environment, as well as RCA personal logs of their daily experiences with odour during caregiving. Thereafter, data were analysed and coded for emerging themes. Read More

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http://dx.doi.org/10.1002/nop2.497DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308701PMC

City sanitation and socioeconomics predict rat zoonotic infection across diverse neighbourhoods.

Zoonoses Public Health 2020 Jun 25. Epub 2020 Jun 25.

Department of Conservation and Science, Lincoln Park Zoo, Chicago, IL, USA.

Rat-associated zoonoses transmitted through faeces or urine are of particular concern for public health because environmental exposure in homes and businesses may be frequent and undetected. To identify times and locations with greater public health risks from rats, we investigated whether rat characteristics, environmental features, socioeconomic factors, or season could predict rat infection risk across diverse urban neighbourhoods. In partnership with a pest management company, we sampled rats in 13 community areas along an income gradient in Chicago, a large city where concern about rats has increased in recent years. Read More

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http://dx.doi.org/10.1111/zph.12748DOI Listing
June 2020
2.065 Impact Factor

Long term outcome of Selective Dorsal Rhizotomy for the management of childhood spasticity-functional improvement and complications.

Childs Nerv Syst 2020 Jun 23. Epub 2020 Jun 23.

Division of Pediatric Neurosurgery, Children's Hospital of British Columbia, Vancouver, Canada.

Background: Selective dorsal rhizotomy (SDR) for the management of lower extremity spasticity is a surgical technique that has existed since the 1900s. While much evidence supports its efficaciousness in reducing tone in the short term, limited information exists detailing the long-term outcome and evolution over time of patients undergoing SDR.

Methods: All publications with 10 years or more of outcome data on patients undergoing SDR were identified from Medline and Embase databases using the search term "Rhizotmy. Read More

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http://dx.doi.org/10.1007/s00381-020-04747-8DOI Listing

Implementation of a behavioural change intervention to enhance oral health behaviours in elite athletes: a feasibility study.

BMJ Open Sport Exerc Med 2020 18;6(1):e000759. Epub 2020 Jun 18.

Centre for Oral Health and Performance, University College London, Eastman Dental Institute, London, UK.

Background: Poor oral health of elite athletes is common and is associated with negative performance impacts. There is a need for oral health promotion strategies that are effective within the elite sport environment.

Aim: To develop, implement and evaluate a pragmatic oral health promotion intervention that integrated the capability, opportunity, motivation and behaviour model of behavioural change into the knowledge transfer system for effective implementation of preventive interventions. Read More

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http://dx.doi.org/10.1136/bmjsem-2020-000759DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304795PMC

Tumor microRNA profile and prognostic value for lymph node metastasis in oral squamous cell carcinoma patients.

Oncotarget 2020 Jun 9;11(23):2204-2215. Epub 2020 Jun 9.

Department of Oral Medical and Biological Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada.

Neck lymph node metastasis (LN+) is one of the most significant prognostic factors affecting 1-in-2 patients diagnosed with oral squamous cell carcinoma (OSCC). The different LN outcomes between clinico-pathologically similar primary tumors suggest underlying molecular signatures that could be associated with the risk of nodal disease development. MicroRNAs (miRNAs)are short non-coding molecules that regulate the expression of their target genes to maintain the balance of cellular processes. Read More

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http://dx.doi.org/10.18632/oncotarget.27616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289532PMC

Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs)-A CleavEx Based Analysis.

Int J Mol Sci 2020 Jun 19;21(12). Epub 2020 Jun 19.

Malopolska Centre of Biotechnology, Jagiellonian University, 30-387 Krakow, Poland.

Kallikrein-related peptidases (KLKs) and matrix metalloproteinases (MMPs) are secretory proteinases known to proteolytically process components of the extracellular matrix, modulating the pericellular environment in physiology and in pathologies. The interconnection between these families remains elusive. To assess the cross-activation of these families, we developed a peptide, fusion protein-based exposition system (age of posed amino acid sequences, CleavEx) aiming at investigating the potential of KLK14 to recognize and hydrolyze proMMP sequences. Read More

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http://dx.doi.org/10.3390/ijms21124383DOI Listing
June 2020
2.862 Impact Factor

Thromboembolic and bleeding risk in obese patients with atrial fibrillation according to different anticoagulation strategies.

Int J Cardiol 2020 Jun 21. Epub 2020 Jun 21.

Chair of Cardiology, University of Pisa, Italy. Electronic address:

Background: Data on the relationship between body mass index (BMI), thromboembolic events (TEE) and bleeding in patients with atrial fibrillation (AF) are controversial, and further evidence on the risk of such events in obese patients with AF receiving different anticoagulant therapies (OAC) is needed.

Methods And Results: We divided a total of 9330 participants from the prospective PREFER in AF and PREFER in AF PROLONGATION registries into BMI quartiles at baseline. Outcome measures were TEE and major bleeding complications at the 1-year follow-up. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.06.010DOI Listing

Effects of progesterone therapy on serum sclerostin levels in healthy menopausal women: a 3-month randomized, placebo-controlled clinical trial.

Osteoporos Int 2020 Jun 20. Epub 2020 Jun 20.

Department of Medicine, Division of Endocrinology, Centre for Menstrual Cycle and Ovulation Research (CeMCOR), University of British Columbia, Vancouver, British Columbia, Canada.

Sclerostin, a natural hormone made in bone, suppresses bone formation. Sclerostin is also decreased by estrogen. Progesterone, estrogen's menstrual partner, stimulates bone formation. Read More

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http://dx.doi.org/10.1007/s00198-020-05505-xDOI Listing

Pros and cons of pre-emptive screening programmes before peanut introduction in infancy.

Lancet Child Adolesc Health 2020 Jul;4(7):526-535

Section of Allergy and Immunology, University of Colorado Denver School of Medicine, Children's Hospital Colorado, Aurora, CO, USA. Electronic address:

Peanut allergy is an important public health concern and causes substantial psychosocial comorbidity. Although fatal anaphylaxis is rare (occurring at 0·03-0·3 per million person-years in the general population), peanuts are one of the most frequent causes of food allergy mortality. The Learning Early About Peanut study transformed prevention of peanut allergy by showing that early introduction of peanut into the diet of children at high risk (ie, those with an egg allergy or severe eczema) reduced the relative risk of peanut allergy at age 5 years by 81%. Read More

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http://dx.doi.org/10.1016/S2352-4642(20)30029-8DOI Listing

Air pollution and systemic inflammation in patients with suspected obstructive sleep apnea living in an urban residential area.

Chest 2020 Jun 16. Epub 2020 Jun 16.

Leon Judah Blackmore Sleep Disorders Program, University of British Columbia, Vancouver, British Columbia, Canada; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada; Canadian Sleep and Circadian Network. Electronic address:

Background: Air pollution and obstructive sleep apnea (OSA) are independently associated with systemic inflammation, but it is unknown if these exposures interact to influence systemic inflammation.

Research Question: Our objective was to determine the relative importance of these factors and their combined potential to influence systemic inflammation in patients under assessment for sleep complaints.

Study Design And Methods: 315 patients contributed data including a questionnaire, polysomnogram and morning serum interleukin (IL) 6 and 10 concentrations. Read More

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http://dx.doi.org/10.1016/j.chest.2020.05.596DOI Listing

Fluorescently Labeled Cetuximab-IRDye800 for Guided Surgical Excision of Ameloblastoma: A Proof of Principle Study.

J Oral Maxillofac Surg 2020 May 19. Epub 2020 May 19.

Assistant Professor, Department of Oral and Maxillofacial Surgery, University of Alabama at Birmingham, Birmingham, AL. Electronic address:

Purpose: Fluorescently labeled epidermal growth factor receptor (EGFR) antibodies have successfully identified microscopic tumors in multiple in vivo models of human cancers with limited toxicity. The present study sought to demonstrate the ability of fluorescently labeled anti-EGFR, cetuximab-IRDye800, to localize to ameloblastoma (AB) tumor cells in vitro and in vivo.

Material And Methods: EGFR expression in AB cells was confirmed by quantitative real-time polymerase chain reaction and immunohistochemistry. Read More

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http://dx.doi.org/10.1016/j.joms.2020.05.022DOI Listing

A Critical Comparison of Canadian and International Guidelines Recommendations for Antiplatelet Therapy in Coronary Artery Disease.

Can J Cardiol 2019 Dec 16. Epub 2019 Dec 16.

Montreal Heart Institute, Department of Medicine, Université de Montréal, Montréal, Québec, Canada. Electronic address:

Antiplatelet therapy for patients with coronary artery disease has evolved dramatically over the last decade. P2Y12 inhibitors offering more potent and consistent platelet inhibition than clopidogrel are now widely available, dual antiplatelet therapy (DAPT) duration can be tailored to individual ischemic and bleeding risks, and strategies to personalize antiplatelet therapy have been developed when concomitant oral anticoagulation (OAC) is indicated. Scientific societies from Canada, the United States, and Europe have all published updated recommendations addressing antiplatelet therapy in the recent years. Read More

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http://dx.doi.org/10.1016/j.cjca.2019.12.013DOI Listing
December 2019

Cancer-associated venous thromboembolism: Treatment and prevention with rivaroxaban.

Res Pract Thromb Haemost 2020 May 4;4(4):532-549. Epub 2020 Apr 4.

Memorial Sloan Kettering Cancer Center New York NY USA.

Cancer-associated venous thromboembolism (VTE) is a frequent, potentially life-threatening event that complicates cancer management. Anticoagulants are the cornerstone of therapy for the treatment and prevention of cancer-associated thrombosis (CAT); factor Xa-inhibiting direct oral anticoagulants (DOACs; apixaban, edoxaban, and rivaroxaban), which have long been recommended for the treatment of VTE in patients without cancer, have been investigated in this setting. The first randomized comparisons of DOACs against low-molecular-weight heparin for the treatment of CAT indicated that DOACs are efficacious in this setting, with findings reflected in recent updates to published guidance on CAT treatment. Read More

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http://dx.doi.org/10.1002/rth2.12327DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292665PMC

Adoptive cell therapy in combination with checkpoint inhibitors in ovarian cancer.

Oncotarget 2020 Jun 2;11(22):2092-2105. Epub 2020 Jun 2.

National Center for Cancer Immune Therapy, Department of Oncology, Copenhagen University Hospital, Herlev, Denmark.

Immune therapy is a promising field within oncology but has been unsuccessful in ovarian cancer (OC). Still, there is rationale and evidence supporting immune therapy in OC. We investigated the potential for adoptive cell therapy (ACT) from in vitro expanded tumor-infiltrating lymphocytes (TILs) in combination with checkpoint inhibitors (ICI) and conducted immunological testing of expanded TILs (REP-TILs). Read More

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http://dx.doi.org/10.18632/oncotarget.27604DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275789PMC

Evaluation of the toxic effect of silver nanoparticles and the possible protective effect of ascorbic acid on the parotid glands of albino rats: An study.

Toxicol Ind Health 2020 Jun 17:748233720933071. Epub 2020 Jun 17.

Department of Oral Biology, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.

This study aimed to evaluate the toxic effect of silver nanoparticles (AgNPs) on the parotid glands (PGs) of albino rats histologically and ultrastructurally and assess the possible protective effect of ascorbic acid as an antioxidant. Thirty male albino rats weighing between 150 mg and 200 mg were divided into three groups: the control group (C1) contained 10 rats that received 2 mg/kg (body weight (bw)) of aqueous nitrate buffer by intraperitoneal (IP) injection daily for 28 days; the AgNPs group contained 10 rats that received 2 mg/kg (bw) IP AgNPs daily for 28 days; and the AgNPs-vitamin C group contained 10 albino rats that received 2 mg/kg (bw) AgNPs IP daily for 28 days with oral administration of 100 mg/kg (bw) vitamin C in drinking water daily for 28 days. The PG acinar and ductal cells of the AgNPs group showed signs of toxicity and degeneration characterized as pleomorphic nuclei, binucleation, cytoplasmic vacuolations, and stagnated secretion in the ductal lumen. Read More

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http://dx.doi.org/10.1177/0748233720933071DOI Listing

Cutting Edge: Intestinal Mucus Limits the Clonal Deletion of Developing T Cells Specific for an Oral Antigen.

J Immunol 2020 Jul 15;205(2):329-334. Epub 2020 Jun 15.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada;

A layer of mucus functions to segregate contents of the intestinal lumen from the intestinal epithelium. The MUC2 mucin is the primary constituent of intestinal mucus and plays critical protective roles against luminal microbes and other noxious agents. In this study, we investigated whether MUC2 helps maintain CD8 T cell tolerance toward intestinal luminal Ags by gavaging wild-type and mice with a model Ag and monitoring immune responses posttreatment. Read More

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http://dx.doi.org/10.4049/jimmunol.1900687DOI Listing

Rivaroxaban was found to be noninferior to warfarin in routine clinical care: A retrospective noninferiority cohort replication study.

Pharmacoepidemiol Drug Saf 2020 Jun 14. Epub 2020 Jun 14.

Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.

Purpose: To compare the effectiveness and safety of a drug in daily practice with the outcomes of a target non-inferiority trial by rigorously mimickingin an observational study the trial's design features.

Methods: This cohort study was conducted using the British Clinical Practice Research Datalink (CPRD) to emulate the ROCKET AF (Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation) trial. Patients with atrial fibrillation who were newly prescribed (>=12 months of no use) either rivaroxaban or warfarinfrom October 2008 to December 2017 were included. Read More

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http://dx.doi.org/10.1002/pds.5065DOI Listing

Technical Protocol for Presenting Maxillofacial Prosthetics Concepts to Dental Students using Interactive 3D Virtual Models within a Portable Document Format.

J Prosthodont 2020 Jun 14. Epub 2020 Jun 14.

Prosthodontics Department, School of Dentistry, University of Bordeaux, Bordeaux, France.

An appropriate presentation of maxillofacial defects and their prosthetic rehabilitation concepts using traditional two-dimensional educational materials is challenging for dental students and prosthodontics residents. This technique article introduces a simple approach to visualize and communicate three-dimensional (3D) virtual models embedded into a portable document format (PDF) file for presenting maxillofacial prosthetics concepts and enhancing students' spatial ability when learning maxillofacial prosthetics. MeVisLab software was used to combine various maxillofacial models and save them as a single 3D model. Read More

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http://dx.doi.org/10.1111/jopr.13210DOI Listing

The differential impact of neuropathic, musculoskeletal and neurovascular orofacial pain on psychosocial function.

J Oral Pathol Med 2020 Jun 12. Epub 2020 Jun 12.

Department of Oral Surgery, King's College London Dental Institute, London, UK.

Background: While the psychosocial morbidity of orofacial pain (OFP) is widely recognized, the differential impact of musculoskeletal, neuropathic and neurovascular symptoms on pain and psychosocial function in individuals with and without coexisting OFP conditions is unclear.

Materials And Methods: This was a comparative cross-sectional study of 350 consecutive patients attending an OFP clinic; 244 completed standardized self-report measures of pain experience, mood, and generic and oral health-related quality of life (HRQoL). The impact of musculoskeletal, neuropathic and neurovascular symptoms on measures was assessed using linear and logistic generalized linear models. Read More

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http://dx.doi.org/10.1111/jop.13071DOI Listing

A Tutorial on Saliva's Role in Swallowing With a Focus on Sjögren's Syndrome.

Am J Speech Lang Pathol 2020 Jun 12:1-13. Epub 2020 Jun 12.

School of Audiology and Speech Sciences, University of British Columbia, Vancouver, Canada.

Purpose Saliva is integral to swallowing and necessary for oral health. Understanding saliva's origin and properties is important for swallowing assessment and management. Diseases such as Sjögren's syndrome (SS) can affect saliva negatively, often contributing to dysphagia. Read More

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http://dx.doi.org/10.1044/2020_AJSLP-19-00083DOI Listing

External Cervical Resorption - A Retrospective Case-Control Study.

J Endod 2020 Jun 7. Epub 2020 Jun 7.

Department of Oral Biological and Medical Sciences,. Electronic address:

Introduction: The current retrospective case-control study examined the potential systemic and local risk factors in relationship to external cervical resorption (ECR). The study hypothesis stated that both local and systemic risks associated with higher ECR rates.

Methods: The ECR group included data about 76 patients (98 teeth) diagnosed with ECR at the university graduate endodontics clinic, from 2008 to 2018. Read More

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http://dx.doi.org/10.1016/j.joen.2020.05.021DOI Listing

Physicochemical and biopharmaceutical characterization of novel Matrix-Liposomes.

Eur J Pharm Biopharm 2020 Aug 6;153:158-167. Epub 2020 Jun 6.

Department of Translational Pulmonology, Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), University of Heidelberg, 69120 Heidelberg, Germany. Electronic address:

Matrix-Liposomes (MLs) are a very promising solid oral drug delivery system; however, data on their interaction with biological membranes are not available. Here, we describe the quality of MLs manufactured by dual centrifugation. MLs were prepared with a Z-average range of 139 to 160 nm and a PDI of 0. Read More

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http://dx.doi.org/10.1016/j.ejpb.2020.06.001DOI Listing

Effects of the Turbine™ on Ventilatory and Sensory Responses to Incremental Cycling.

Med Sci Sports Exerc 2020 Jun 8. Epub 2020 Jun 8.

Centre for Heart Lung Innovation, Providence Health Care Research Institute, The University of British Columbia, St. Paul's Hospital, Vancouver, BC, Canada.

Introduction: The Turbine™ is a nasal dilator marketed to athletes to increase airflow, which may serve to reduce dyspnea and improve exercise performance, presumably via reductions in the work of breathing (WOB). However, the unpublished data supporting these claims were collected in individuals at rest that were exclusively nasal breathing. These data are not indicative of how the device influences breathing during exercise at higher ventilations when a larger proportion of breathing is through the mouth. Read More

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http://dx.doi.org/10.1249/MSS.0000000000002427DOI Listing

Higher sugar intake is associated with periodontal disease in adolescents.

Clin Oral Investig 2020 Jun 9. Epub 2020 Jun 9.

Postgraduate Program of Dentistry, Federal University of Maranhão, Av. dos Portugueses 1966, Cidade Universitária Bacanga, São Luís, MA, 65080-805, Brazil.

Objectives: Analyze the association between higher added sugar exposure and periodontal disease in adolescents (18-19 years old).

Materials And Methods: This was a cross-sectional study nested to RPS Cohorts Consortium, São Luís, Brazil (n = 2515). The exposure was percentage of daily calories from added sugar (≥ 10%), estimated from a quantitative food frequency. Read More

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http://dx.doi.org/10.1007/s00784-020-03387-1DOI Listing

Prevalence, Extent, and Severity of Oral Health Impacts Among Adults in Rural Karnataka, India.

JDR Clin Trans Res 2020 Jun 9:2380084420932163. Epub 2020 Jun 9.

Australian Research Centre for Population Oral Health, The University of Adelaide, Australia (ARCPOH).

Introduction: Oral health affects quality of life. Many studies have investigated the factors associated with oral health-related quality of life (OHRQoL). Little is known about OHRQoL of adults living in rural and remote areas of India, where many have lower levels of education and limited availability of oral health care services. Read More

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http://dx.doi.org/10.1177/2380084420932163DOI Listing

Dynamics of Dissolution, Killing, and Inhibition of Dental Plaque Biofilm.

Front Microbiol 2020 20;11:964. Epub 2020 May 20.

Division of Endodontics, Department of Oral Biological and Medical Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, BC, Canada.

The present study aims to establish a standardized model that makes it possible to evaluate the dynamic dissolution of biofilm, killing of biofilm microbes and inhibition of growth of biofilm by disinfecting solutions. Biofilm was grown from dental plaque bacteria on collagen-coated hydroxyapatite (HA) disks for 3 days or 3 weeks under anaerobic conditions. Biofilms were stained with the LIVE/DEAD viability stain and subjected to sterile water, 2% sodium hypochlorite (NaOCl), 6% NaOCl, or 2% chlorhexidine (CHX) for 32 min. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7251032PMC

Oral health status and barriers to care in a multiethnic mixed disability center: Rethinking disability community dental services.

Spec Care Dentist 2020 Jul 5;40(4):344-355. Epub 2020 Jun 5.

Nanyang Polytechnic, Oral Health Therapy, 180 Ang Mo Kio Ave 8, 569830, Singapore.

Aims: There are currently neither onsite services nor any known studies that addresses oral health of persons with special care needs (PSCN) within disability activity centers in Singapore. This study aims to report on the oral health status, disability-related barriers, and assess how these barriers limit care pathways.

Methods And Results: 29 PSCN from a multiethnic mixed disability day activity center were screened over two days. Read More

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http://dx.doi.org/10.1111/scd.12483DOI Listing

Obstructive Sleep Apnea and Circulating Biomarkers of Oxidative Stress: A Cross-Sectional Study.

Antioxidants (Basel) 2020 Jun 2;9(6). Epub 2020 Jun 2.

Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada.

Oxidative stress (OS) drives cardiometabolic diseases. Intermittent hypoxia consistently increases oxidative stress markers. Obstructive sleep apnea (OSA) patients experience intermittent hypoxia and an increased rate of cardiovascular disease, however, the impact of OSA on OS markers is not clear. Read More

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http://dx.doi.org/10.3390/antiox9060476DOI Listing

Effect of canal curvature location on the cyclic fatigue resistance of reciprocating files.

Clin Oral Investig 2020 Jun 2. Epub 2020 Jun 2.

Division of Endodontics, Faculty of Dentistry, The University of British Columbia (UBC), 2199 Wesbrook Mall, Vancouver, V6T1Z3, Canada.

Objectives: To determine the effect of the location of the canal curvature on the fatigue resistance of WaveOne (WO), WaveOne Gold (WOG), Reciproc (Rec), and Reciproc Blue (RecB) files, and to examine the phase transformation behaviors of the reciprocating file systems.

Material And Methods: The instruments were subjected to fatigue testing in five artificial canals with a curvature of 60° angle and a 3-mm radius. The location of the curvature was unique for each canal. Read More

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http://dx.doi.org/10.1007/s00784-020-03348-8DOI Listing

Master Sculptor at Work: Enteropathogenic Escherichia coli Infection Uniquely Modifies Mitochondrial Proteolysis during Its Control of Human Cell Death.

mSystems 2020 Jun 2;5(3). Epub 2020 Jun 2.

Department of Microbiology & Immunology, University of British Columbia, Vancouver, Canada

Enteropathogenic (EPEC) causes severe diarrheal disease and is present globally. EPEC virulence requires a bacterial type III secretion system to inject >20 effector proteins into human intestinal cells. Three effectors travel to mitochondria and modulate apoptosis; however, the mechanisms by which effectors control apoptosis from within mitochondria are unknown. Read More

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http://dx.doi.org/10.1128/mSystems.00283-20DOI Listing

What can a dentist and dental sleep apnea researcher do under COVID-19 lockdown?

J Clin Sleep Med 2020 Jun 2. Epub 2020 Jun 2.

Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.5664/jcsm.8604DOI Listing

Maxillary Sinus Ameloblastoma: Transnasal Endoscopic Management.

Ear Nose Throat J 2020 Jun 2:145561320930555. Epub 2020 Jun 2.

Department of Otolaryngology, University of British Columbia and St Paul's Sinus Centre, Vancouver, British Columbia, Canada.

Ameloblastoma (AM) is a slow growing and aggressive benign tumor with an odontogenic epithelial origin arising from the mandible or maxilla. The odontogenic neoplasm invades local tissues asymptomatically and accounts for 1% of oral tumors and over 10% of odontogenic tumors. A 64-year-old man with a history of allergic fungal rhinosinusitis (AFRS) undergoing a revision image-guided endoscopic sinus surgery was found to have a fibrous mass suspicious of malignancy projecting inferolaterally and attached to the floor of the left maxillary sinus. Read More

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http://dx.doi.org/10.1177/0145561320930555DOI Listing

Efficacy of teriparatide compared with risedronate on FRAX-defined major osteoporotic fractures: results of the VERO clinical trial.

Osteoporos Int 2020 May 30. Epub 2020 May 30.

Maastricht University Medical Center, Maastricht, The Netherlands.

FRAX calculates the 10-year probability of major osteoporotic fractures (MOF), which are considered to have a greater clinical impact than other fractures. Our results suggest that, in postmenopausal women with severe osteoporosis, those treated with teriparatide had a 60% lower risk of FRAX-defined MOF compared with those treated with risedronate.

Introduction: The VERO trial was an active-controlled fracture endpoint clinical trial that enrolled postmenopausal women with severe osteoporosis. Read More

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http://dx.doi.org/10.1007/s00198-020-05463-4DOI Listing

Assessing comprehension and perceptions of modified-risk information for snus among adult current cigarette smokers, former tobacco users, and never tobacco users.

Addict Behav Rep 2020 Jun 24;11:100254. Epub 2020 Jan 24.

RAI Services Company, 401 North Main Street, Winston-Salem, NC 27101, United States.

Introduction: Snus, a low nitrosamine smokeless tobacco product, presents less risks to health than cigarettes. Effectively communicating such risk information could facilitate smokers switching completely to snus, thereby benefiting public health.

Methods: This study assessed comprehension and perceptions of modified-risk information regarding snus. Read More

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http://dx.doi.org/10.1016/j.abrep.2020.100254DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7244929PMC

Intravenous cannula placement in children for induction of general anesthesia: Prospective audit and identification of success factors.

Paediatr Anaesth 2020 May 28. Epub 2020 May 28.

Research Institute, BC Children's Hospital, Vancouver, BC, Canada.

Background: Approaches to pediatric induction of anesthesia vary widely. While oral sedative premedication and inhalational induction are common, total intravenous anesthesia is becoming increasingly popular. Total intravenous anesthesia without anxiolytic premedication, which is the most commonly used technique in our hospital, requires intravenous (IV) cannula placement in an awake child. Read More

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http://dx.doi.org/10.1111/pan.13936DOI Listing
May 2020
1.742 Impact Factor