4,883 results match your criteria British Journal Of Oral & Maxillofacial Surgery[Journal]


First Real-World Safety Analysis of Preschool Peanut Oral Immunotherapy.

J Allergy Clin Immunol Pract 2019 Apr 16. Epub 2019 Apr 16.

British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada; Division of Allergy and Immunology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.

Background: In 2017, a clinical trial of 37 subjects demonstrated that preschool peanut oral immunotherapy (P-OIT) was safe, with predominantly mild symptoms reported and only 1 moderate reaction requiring epinephrine.

Objectives: We sought to examine whether these findings would be applicable in a real-world setting.

Methods: As part of a Canada-wide quality improvement project, academic and community allergists administered P-OIT to preschool-age children who had (1) skin prick test wheal diameter greater than or equal to 3 mm or specific IgE level greater than or equal to 0. Read More

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http://dx.doi.org/10.1016/j.jaip.2019.04.010DOI Listing
April 2019
2 Reads

The Effect of an Audiovisual Preoperative Intervention in Reducing Parental Anxiety Prior to a Child's Sedation Appointment: A Pilot Study.

Pediatr Dent 2019 Mar;41(2):112-118

Dr. Mathu-Muju is associate professor of pediatric dentistry, Faculty of Dentistry, University of British Columbia, Vancouver, British Columbia, Canada;, Email:

The purpose of this pilot study was to determine whether an audiovisual intervention was more effective than verbal instructions at reducing preoperative anxiety levels for parents whose children were having their first experience of dental treatment with the use of oral sedation. A prospective clinical trial was conducted. Parents were systematically assigned to either view an animated video (intervention group) or receive standardized verbal instructions (control group). Read More

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March 2019
1 Read

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy.

N Engl J Med 2019 Apr 14. Epub 2019 Apr 14.

From the George Institute for Global Health, University of New South Wales Sydney (V.P., M.J.J., B.N., S. Bompoint), the Royal North Shore Hospital (V.P.), Concord Repatriation General Hospital (M.J.J.), and the Charles Perkins Centre, University of Sydney (B.N.), Sydney, and the Kolling Institute of Medical Research, Sydney Medical School, University of Sydney, Royal North Shore Hospital, St. Leonards, NSW (C.P.) - all in Australia; Imperial College London (B.N.) and the Department of Renal Medicine, UCL Medical School (D.C.W.) - both in London; the Department of Clinical Pharmacy and Pharmacology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands (H.J.L.H., D.Z.); the Nephrology Division, NYU School of Medicine and NYU Langone Medical Center, New York (D.M.C.); Baim Institute for Clinical Research (D.M.C., C.P.C., B.M.B.), the Cardiovascular Division (C.P.C.) and the Renal Division and Department of Medicine (B.M.B), Brigham and Women's Hospital, and Harvard Medical School (B.M.B.) - all in Boston; Janssen Research and Development, Raritan, NJ (R.E., S. Bull, G.C., P.-L.C., Y.Y., G.M.); Indiana University School of Medicine and Veterans Affairs Medical Center, Indianapolis (R.A.); the Department of Medicine, University of Chicago Medicine, Chicago (G.B.); the Division of Biostatistics, Department of Population Health Sciences, University of Utah, Salt Lake City (T.G.); the Division of Nephrology, University of British Columbia, Vancouver (A.L.), and the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto (B.Z.) - all in Canada; the Renal Division, Peking University First Hospital, Beijing (H.Z.); and the Stanford Center for Clinical Research, Department of Medicine, Stanford University School of Medicine, Stanford, CA (K.W.M.).

Background: Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium-glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes.

Methods: In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1811744
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http://dx.doi.org/10.1056/NEJMoa1811744DOI Listing
April 2019
7 Reads

Omalizumab in patients with severe asthma and persistent sputum eosinophilia.

Allergy Asthma Clin Immunol 2019 3;15:21. Epub 2019 Apr 3.

1Department of Medicine, Division of Respirology, McMaster University, Hamilton, ON Canada.

Omalizumab, a recombinant humanized monoclonal antibody targeting the IgE molecule, is the first biologic approved for moderate-to-severe allergic asthmatics, who remain uncontrolled despite high dose inhaled corticosteroid and bronchodilators. Steroid-sparing effect of omalizumab has not been demonstrated in asthmatics with persistent airway eosinophilia in a randomised controlled trial till date. From this double-blind, placebo-controlled, multi-centred, randomized parallel group design, we report that omalizumab is possibly inadequate to control sputum eosinophilia, and therefore may not have a steroid-sparing effect, especially in those maintained on oral corticosteroids daily. Read More

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http://dx.doi.org/10.1186/s13223-019-0337-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448265PMC
April 2019
2 Reads

Proteases and their inhibitors as prognostic factors for high-grade serous ovarian cancer.

Pathol Res Pract 2019 Mar 2. Epub 2019 Mar 2.

Laval University Cancer Research Center and Research Center of the Centre Hospitalier Universitaire (CHU) de Québec, Ville de Québec, QC, G1R 3S3, Canada.

Ovarian carcinoma is one of the most lethal malignancies, but only very few prognostic biomarkers are known. The degradome, comprising proteases, protease non-proteolytic homologues and inhibitors, have been involved in the prognosis of many cancer types, including ovarian carcinoma. The prognostic significance of the whole degradome family has not been specifically studied in high-grade serous ovarian cancer. Read More

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http://dx.doi.org/10.1016/j.prp.2019.02.019DOI Listing
March 2019
2 Reads

Toward Completion of the Human Proteome Parts List: Progress Uncovering Proteins That Are Missing or Have Unknown Function and Developing Analytical Methods.

J Proteome Res 2018 Dec;17(12):4023-4030

Institute for Systems Biology, Departments of Computational Medicine & Bioinformatics, Internal Medicine, and Human Genetics & School of Public Health, University of Michigan.

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http://dx.doi.org/10.1021/acs.jproteome.8b00885DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288998PMC
December 2018

Taurodontism.

Authors:
David MacDonald

Oral Radiol 2019 Apr 12. Epub 2019 Apr 12.

Division of Oral and Maxillofacial Radiology, University of British Columbia, 2199 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada.

Taurodontism was hitherto considered to be a marker of oro-facial disorders. Since then, it has been reported with a moderately high-to-high prevalence on panoramic radiographs in case series of otherwise normal individuals a number of Middle Eastern and East Asian communities. This now understood higher than-formerly expected prevalence is important to the endodontist, orthodontist and restorative dentist. Read More

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http://dx.doi.org/10.1007/s11282-019-00386-1DOI Listing

School-Based Dental Education for Improving Oral Self-Care in Mexican Elementary School-Aged Children.

Health Promot Pract 2019 Apr 11:1524839919840342. Epub 2019 Apr 11.

1 National Autonomous University of Mexico, León, Guanajuato, Mexico.

Aim: To test the efficiency and acceptance of school-based dental education for improving oral self-care in Mexican elementary school-aged children.

Method: A total of 408 students from 4 schools were examined at the baseline, 3 months (follow-up rate was 94%) and 6 months observations (follow-up rate 91%). Group 1 served as a control, Group 2 received a lecture-based education, and Group 3 consisted of trained peer-leaders who educated their peers. Read More

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http://dx.doi.org/10.1177/1524839919840342DOI Listing

Long-Acting Injectable Second-Generation/Atypical Antipsychotics for the Management of Bipolar Disorder: A Systematic Review.

CNS Drugs 2019 Apr 8. Epub 2019 Apr 8.

Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.

Background: Non-adherence to medications is a major determinant of poor outcome in bipolar disorder. Second-generation long-acting injectable (LAI) antipsychotics help ensure medication adherence which in turn can lead to more favourable outcomes. However, the role of these medications in bipolar disorder is not well established. Read More

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http://dx.doi.org/10.1007/s40263-019-00629-zDOI Listing
April 2019
2 Reads

Evaluation of The Bio-Stimulatory Effect of Platelet Rich Fibrin Augmented by Diode LASER Compared to Platelet Rich Fibrin Alone on Dental Implant Replacing Posterior Mandibular Teeth. Randomised Clinical Trial: Split Mouth Study.

Open Access Maced J Med Sci 2019 Mar 14;7(5):869-875. Epub 2019 Mar 14.

Faculty of Dentistry, Cairo University, Cairo, Egypt.

Background: Restoring masticatory function and replacing missing teeth with minimal pain and discomfort are the most important issues for the patient and clinician. Nowadays dental implants became the most popular line of treatment to replace missing teeth; offering a comfortable long lasting prosthesis. Osseo-integration reflects the long term success of a dental implant. Read More

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https://www.id-press.eu/mjms/article/view/oamjms.2019.183
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http://dx.doi.org/10.3889/oamjms.2019.183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447333PMC
March 2019
1 Read

A peer-led dental education program for modifying oral self-care in Mexican children.

Salud Publica Mex 2019 Mar-Apr;61(2):193-201

Escuela Nacional de Estudios Superiores Unidad León, Universidad Nacional Autónoma de México. León, Guanajuato, México.

Objective: To compare peer-led dental education (PLDE) versus conventional dental instruction (CDI) in modifying children's oral self-care.

Materials And Methods: The intervention group (two schools) received PLDE and the control group (two schools) received CDI. The quality of oral self-care practice (OSC-P) and oral self-care skills (OSC-S) were indicated by dental plaque levels (%) and compared before and after dental education. Read More

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http://dx.doi.org/10.21149/9273DOI Listing
November 2017

Predicting fracture risk in patients with chronic obstructive pulmonary disease: a UK-based population-based cohort study.

BMJ Open 2019 Apr 3;9(4):e024951. Epub 2019 Apr 3.

Nottingham Respiratory Research Unit, NIHR Nottingham Biomedical Research Centre, School of Medicine, University of Nottingham, Nottingham, UK.

Objective: To assess the incidence of hip fracture and all major osteoporotic fractures (MOF) in patients with chronic obstructive pulmonary disease (COPD) compared with non-COPD patients and to evaluate the use and performance of fracture risk prediction tools in patients with COPD. To assess the prevalence and incidence of osteoporosis.

Design: Population-based cohort study. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024951DOI Listing
April 2019
4 Reads

Use of antibacterial toothpaste is associated with higher urinary triclosan concentrations in Asian immigrant women living in Vancouver, Canada.

Sci Total Environ 2019 Mar 25;671:897-904. Epub 2019 Mar 25.

Environmental Health Services, British Columbia Centre for Disease Control (BCCDC), Vancouver, BC, Canada.

Background: Triclosan is an antibacterial added to consumer products including toothpastes, cosmetics, and plastic cutting boards. Known to disrupt reproductive and hormonal functioning in animals, epidemiological studies indicate that exposure to triclosan may have similar effects on human health.

Methods: 100 women aged 19 to 45 years born in India or China, Hong Kong, and Taiwan new to the Vancouver (Canada) area were recruited in 2015-2016 by word of mouth, public advertisements, and contacts in health and cultural organizations. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.379DOI Listing

Slow release oral morphine versus methadone for the treatment of opioid use disorder.

BMJ Open 2019 Apr 2;9(4):e025799. Epub 2019 Apr 2.

BC Centre on Substance Use, Vancouver, Canada.

Objective: To assess the efficacy of slow release oral morphine (SROM) as a treatment for opioid use disorder (OUD).

Design: Systematic review and meta-analysis of randomised controlled trials (RCTs).

Data Sources: Three electronic databases were searched through 1 May 2018: the Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025799DOI Listing
April 2019
1 Read

Association of Canadian Faculties of Dentistry Educational Framework for the Development of Competency in Dental Programs.

J Dent Educ 2019 Apr;83(4):464-473

Anne Charbonneau, PhD, is Professor and former Associate Dean for Academic Development, Département de santé buccale, Faculté de médecine dentaire, Université de Montréal; Joanne N. Walton, DDS, Dip Pros, FRCD(C), is Professor Emeritus and former Associate Dean for Academic and Student Affairs, Faculty of Dentistry, University of British Columbia; Sylvie Morin, DMD, MSc, is Professor, Département de restauration, and former Curriculum Director, Faculté de médecine dentaire, Université Laval; and Marie Dagenais, DMD, Dip Oral Radiol, is Executive Director and Registrar, National Dental Examining Board of Canada and former Associate Dean for Academic Affairs, Faculty of Dentistry, McGill University.

The Association of Canadian Faculties of Dentistry (ACFD) recently developed a proposal that reflects its evolving understanding of competency-based dental education. The ACFD proposal was developed into an Educational Framework for the Development of Competency in Dental Programs and has been adopted by all ten Canadian dental schools as the basis for their ongoing curriculum development and assessment. This framework identifies five global competencies that provide a big picture of the complex skills, knowledge, and behaviors that dental graduates must demonstrate. Read More

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http://dx.doi.org/10.21815/JDE.019.045DOI Listing
April 2019
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Combined GS-4774 and Tenofovir Therapy can Improve HBV-Specific T-Cell Responses in Patients with Chronic Hepatitis.

Gastroenterology 2019 Mar 28. Epub 2019 Mar 28.

Laboratory of Viral Immunopathology, Department of Medicine and Surgery, University of Parma and Unit of Infectious Diseases and Hepatology, Azienda-Ospedaliero-Universitaria of Parma, Parma, Italy. Electronic address:

Background & Aims: One strategy to treat chronic hepatitis B virus (HBV) infection could be to increase the functions of virus-specific T cells. We performed a multicenter phase 2 study to evaluate the safety and efficacy of GS-4774, a yeast-based therapeutic vaccine engineered to express HBV antigens, given with tenofovir disoproxil fumarate (TDF) to untreated patients with chronic HBV infection.

Methods: We performed an open-label study at 34 sites in Canada, Italy, New Zealand, Romania, South Korea and United States from July 2014 to August 2016. Read More

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http://dx.doi.org/10.1053/j.gastro.2019.03.044DOI Listing
March 2019
2 Reads
16.716 Impact Factor

Nanocrystalline cellulose as a reinforcing agent for electrospun polyacrylonitrile (PAN) nanofibers.

J Oral Biosci 2019 Mar 13;61(1):37-42. Epub 2018 Oct 13.

Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, 2199 Westbrook Mall, JBM 368, Vancouver, Canada BC V6T 1Z3. Electronic address:

Objectives: Nanocrystalline cellulose (NCC) is a sustainable material with excellent mechanical properties and can potentially be used as a reinforcement agent. The objective of this work was to test the effects of NCC incorporation on the mechanical properties of electrospun polyacrylonitrile (PAN) nanofibers.

Methods: Eleven percent in weight of PAN (molecular weight 150 kD) in a dimethylformamide (DMF) solution was electrospun at 14. Read More

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http://dx.doi.org/10.1016/j.job.2018.09.002DOI Listing

Risk factors for thromboembolic and bleeding events in anticoagulated patients with atrial fibrillation: the prospective, multicentre observational PREvention oF thromboembolic events - European Registry in Atrial Fibrillation (PREFER in AF).

BMJ Open 2019 Mar 30;9(3):e022478. Epub 2019 Mar 30.

University of Birmingham Institute of Cardiovascular Sciences, University of Birmingham, UHB and SWBH NHS Trusts, Birmingham, UK.

Objectives: We identified factors associated with thromboembolic and bleeding events in two contemporary cohorts of anticoagulated patients with atrial fibrillation (AF), treated with either vitamin K antagonists (VKA) or non-VKA oral anticoagulants (NOACs).

Design: Prospective, multicentre observational study.

Setting: 461 centres in seven European countries. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022478DOI Listing
March 2019
2 Reads

Dry-bonding to dentin using alternative conditioners based on iron-containing solutions or nitric acid.

J Mech Behav Biomed Mater 2019 Jun 20;94:238-248. Epub 2019 Mar 20.

Department of Restorative Dentistry, Operative Dentistry Division, Piracicaba Dental School, University of Campinas, Avenida Limeira 901, Bairro Areião, 13414-903 Piracicaba, SP, Brazil. Electronic address:

Objectives: To evaluate the effect of experimental conditioners (10-3 solution - 10-3, 6.8% ferric oxalate - FOX, and 1.4% nitric acid - NI) on dentin elastic modulus, flexural strength, bond strength, failure mode, and adhesive interface morphology of two etch-and-rinse adhesives (XP Bond, Dentsply or One-Step, Bisco) applied on etched dry dentin. Read More

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http://dx.doi.org/10.1016/j.jmbbm.2019.03.015DOI Listing

Effect of Oral Contraceptives on Soft Tissue Injury Risk, Soft Tissue Laxity, and Muscle Strength: A Systematic Review of the Literature.

Orthop J Sports Med 2019 Mar 22;7(3):2325967119831061. Epub 2019 Mar 22.

Department of Orthopaedic Surgery, Stanford University Medical Center, Stanford, California, USA.

Background: Female patients are more likely than male patients to experience various musculoskeletal (MSK) injuries. Because MSK tissues are sensitive to the female hormones relaxin, estrogen, and progesterone, studies have examined whether hormonal contraceptives, which change female hormone levels, can alter the female MSK injury risk. These studies have reached contradictory conclusions, leaving unclear the influence of hormonal contraception on female MSK injury risk. Read More

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http://dx.doi.org/10.1177/2325967119831061DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431771PMC
March 2019
1 Read

Utilization of primary health care services among Syrian refugee and Lebanese women targeted by the ICRC program in Lebanon: a cross-sectional study.

Confl Health 2019 15;13. Epub 2019 Mar 15.

Harvard François Xavier Bagnoud Center for Health and Human Rights, Boston, USA.

Background: The Syrian crisis has put tremendous strain on the Lebanese health system, particularly in the historically underserved border region. The ICRC Primary Health Care program has focused on refugee and host communities in these areas. This study objectives were: 1) to determine whether the ICRC program was reaching the most vulnerable populations; 2) to understand the key perceived health needs in the catchment areas of the ICRC supported facilities; and 3) to identify barriers to utilization of health care services. Read More

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http://dx.doi.org/10.1186/s13031-019-0190-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420751PMC

Efficacy and Safety of Bempedoic Acid in Patients With Hypercholesterolemia and Statin Intolerance.

J Am Heart Assoc 2019 Apr;8(7):e011662

6 Department of Vascular Medicine Academic Medical Center of Amsterdam Netherlands.

Background Inability to tolerate statins because of muscle symptoms contributes to uncontrolled cholesterol levels and insufficient cardiovascular risk reduction. Bempedoic acid, a prodrug that is activated by a hepatic enzyme not present in skeletal muscle, inhibits ATP -citrate lyase, an enzyme upstream of β-hydroxy β-methylglutaryl-coenzyme A reductase in the cholesterol biosynthesis pathway. Methods and Results The phase 3, double-blind, placebo-controlled CLEAR (Cholesterol Lowering via Bempedoic acid, an ACL-Inhibiting Regimen) Serenity study randomized 345 patients with hypercholesterolemia and a history of intolerance to at least 2 statins (1 at the lowest available dose) 2:1 to bempedoic acid 180 mg or placebo once daily for 24 weeks. Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.011662
Publisher Site
http://dx.doi.org/10.1161/JAHA.118.011662DOI Listing
April 2019
4 Reads

Higher Insulin Resistance & Adiposity in Post-menopausal Women With Breast Cancer Treated With Aromatase Inhibitors.

J Clin Endocrinol Metab 2019 Mar 28. Epub 2019 Mar 28.

University/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, United Kingdom.

Context: Aromatase deficiency causes obesity and insulin resistance in aromatase knockout mice and humans with rare mutations of the aromatase gene (CYP19). Aromatase inhibitors are a commonly prescribed therapy in post-menopausal breast cancer.

Objective: We hypothesized that aromatase inhibitors induce obesity and insulin resistance when used in treatment of breast cancer. Read More

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http://dx.doi.org/10.1210/jc.2018-02339DOI Listing
March 2019
1 Read

Oral Ketone Supplementation Acutely Increases Markers of NLRP3 Inflammasome Activation in Human Monocytes.

Mol Nutr Food Res 2019 Mar 25:e1801171. Epub 2019 Mar 25.

School of Health and Exercise Sciences, University of British Columbia, Okanagan Campus, Kelowna, BC, V1V 1V7, Canada.

Scope: Cell culture studies indicate that the ketone β-hydroxybutyrate (β-OHB) directly inhibits the NLRP3 inflammasome, a key regulator of inflammation. However, direct evidence demonstrating this effect in humans is lacking.

Methods And Results: To determine the effects of acutely raising blood β-OHB in healthy humans, two separate randomized double-blind placebo-controlled experiments are conducted using similar methods but each employed different exogenous ketone supplements. Read More

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http://dx.doi.org/10.1002/mnfr.201801171DOI Listing
March 2019
1 Read

The Upper Airway Nasal Complex: Structural Contribution to Persistent Nasal Obstruction.

Otolaryngol Head Neck Surg 2019 Mar 26:194599819838262. Epub 2019 Mar 26.

1 Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, USA.

Objective: To determine the contribution of the nasal floor and hard palate morphology to nasal obstruction for nonresponders to prior intranasal surgery.

Study Design: Retrospective case-control study.

Setting: Tertiary academic center. Read More

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http://dx.doi.org/10.1177/0194599819838262DOI Listing
March 2019
2 Reads

Birth weight, verbal cognition in early adolescence, and lexical and reading skills in late adolescence: a formal mediation analysis using a potential outcomes approach.

J Child Psychol Psychiatry 2019 Mar 25. Epub 2019 Mar 25.

Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.

Background: Oral and written language in late adolescence are influenced by many pre- and postnatal factors, including cognitive performance at earlier ages. We investigated whether the association between birth weight and lexical knowledge and reading comprehension in late adolescence (14-16 years) is mediated by verbal cognition during early adolescence (10-11 years).

Methods: We conducted a mediation analysis via a potential outcomes approach to data from three United Kingdom (UK) prospective birth cohorts - The National Child Development Study (NCDS; year of birth (Y. Read More

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http://dx.doi.org/10.1111/jcpp.13043DOI Listing

Reliability of Cognitive Measures in Individuals with a Chronic Spinal Cord Injury.

PM R 2019 Mar 22. Epub 2019 Mar 22.

International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, Canada.

Background: Cognitive deficit is a common impairment in individuals with spinal cord injury (SCI), with an incidence of up to 64%. However, the reliability of commonly used neuropsychological tests is currently unknown in this population.

Objectives: To evaluate the test-retest reliability of cognitive measures in individuals with SCI. Read More

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http://dx.doi.org/10.1002/pmrj.12161DOI Listing
March 2019
3 Reads

Intrauterine Contraception: Knowledge and Prescribing Practices of Canadian Health Care Providers.

J Obstet Gynaecol Can 2019 Mar 18. Epub 2019 Mar 18.

Department of Obstetrics and Gynaecology, University of Western Ontario, London, ON.

Objective: Contraception is an important issue in the lives of women, their partners, and society. Canadians and their health care providers play a critical role in contraceptive decision making that influences individuals and Canadian society. The purpose of this study was to gather data on contraception-related knowledge, counselling, and prescribing practices of Canadian health care providers. Read More

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http://dx.doi.org/10.1016/j.jogc.2018.11.027DOI Listing
March 2019
1 Read

Digital Workflow of Auricular Rehabilitation: A Technical Report Using an Intraoral Scanner.

J Prosthodont 2019 Mar 18. Epub 2019 Mar 18.

Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada.

Prosthodontic rehabilitation of a congenital or acquired defect of the ear is considered a challenging and skill-dependent procedure. This technical report describes a novel approach for direct digital scanning of the unaffected contralateral ear using an intraoral scanner and external markers. The obtained digital data of the ear was exported, digitally mirrored, and successfully positioned to a virtual model of a human head with a missing ear. Read More

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http://dx.doi.org/10.1111/jopr.13057DOI Listing

Nasopharyngeal Tube Effects on Breathing during Sedation for Dental Procedures: A Randomized Controlled Trial.

Anesthesiology 2019 Mar 11. Epub 2019 Mar 11.

From the Department of Anesthesiology, Graduate School of Medicine, Chiba University, Chiba, Japan (Y.K., S.I.) the Department of Anesthesiology, Showa University Koto Toyosu Hospital, Tokyo, Japan (Y.K., T.S.) the Department of Perioperative Medicine, Division of Anesthesiology, Showa University School of Dentistry, Tokyo, Japan (Y.K., S.O., A.K., T.I.) the Department of Dental Anesthesiology and Orofacial Pain, Graduate School of Dentistry, Kyusyu Dental University, Fukuoka, Japan (K.K.) the Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada (F.R.A.) the Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan (Y.S.).

What We Already Know About This Topic: Dental procedures under sedation can cause hypoxic events and even death. However, the mechanism of such hypoxic events is not well understood.

What This Article Tells Us That Is New: Apnea and hypopnea occur frequently during dental procedures under sedation. Read More

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http://dx.doi.org/10.1097/ALN.0000000000002661DOI Listing
March 2019
1 Read

PIK3CA alterations and benefit with neratinib: analysis from the randomized, double-blind, placebo-controlled, phase III ExteNET trial.

Breast Cancer Res 2019 03 11;21(1):39. Epub 2019 Mar 11.

Breast Cancer Research Centre-WA, Perth & Curtin University, Nedlands, Australia.

Background: Neratinib is an irreversible pan-HER tyrosine kinase inhibitor that inhibits PI3K/Akt and MAPK signaling pathways after HER2 receptor activation. The ExteNET study showed that neratinib significantly improved 5-year invasive disease-free survival (iDFS) in women who completed trastuzumab-based adjuvant therapy for early breast cancer (EBC). We assessed the prognostic and predictive significance of PIK3CA alterations in patients in ExteNET. Read More

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http://dx.doi.org/10.1186/s13058-019-1115-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6417207PMC
March 2019
8 Reads

History of the International Association of Paediatric Dentistry: A 50-year perspective.

Int J Paediatr Dent 2019 Mar 12. Epub 2019 Mar 12.

Department of Pediatric Dentistry, Wan Fang Medical Center, Taipei Medical University, Taipei, Taiwan.

This paper demonstrates how the International Association of Paediatric Dentistry (IAPD) arose from small beginnings in 1967. What started as an International Forum on Child Dental Health in London grew to become first the International Association of Dentistry for Children and then the outstanding IAPD with biennial congresses, regional meetings, cooperation with other children's organisations, Teach the Teachers programmes, a wonderful website and this International Journal of Paediatric Dentistry. There are now 70 national member societies world-wide representing over 16,000 members with a single interest: to further the oral health care of children. Read More

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http://dx.doi.org/10.1111/ipd.12492DOI Listing
March 2019
1 Read
1.540 Impact Factor

In vivo anti-inflammatory activity and UPLC-MS/MS profiling of the peels and pulps of Cucumis melo var. cantalupensis and Cucumis melo var. reticulatus.

J Ethnopharmacol 2019 Mar 9;237:245-254. Epub 2019 Mar 9.

Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.

Ethnopharmacological Relevance: Cucumis melo var. cantalupensis and Cucumis melo var. reticulatus are the most famous varieties of netted muskmelon or cantaloupe in Egypt. Read More

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http://dx.doi.org/10.1016/j.jep.2019.03.015DOI Listing

Selected medical interventions in women with a deleterious mutation: a population-based study in British Columbia.

Curr Oncol 2019 Feb 1;26(1):e17-e23. Epub 2019 Feb 1.

Laboratory Medicine, University of British Columbia, Vancouver, BC.

Background: We examined the uptake of risk-reducing interventions, including bilateral mastectomy, risk-reducing salpingo-oophorectomy, oral contraceptive pills, tamoxifen, and raloxifene, for the entire population of women with a deleterious or mutation in the Canadian province of British Columbia.

Methods: This retrospective population-based study used data available in British Columbia for all women who, between 1996 and 2014, were tested and found to have a mutation. Rates of risk-reducing interventions stratified according to the type of mutation and prior history of breast or gynecologic cancer (ovary, fallopian tube, peritoneal) are presented. Read More

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http://dx.doi.org/10.3747/co.26.4068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380629PMC
February 2019
2 Reads

Severity and Outcome Assessment score: a useful tool for auditing orthognathic surgery.

Br J Oral Maxillofac Surg 2019 Mar 6. Epub 2019 Mar 6.

Dundee Dental School, Dundee. Electronic address:

Many indices and scoring systems exist for assessing skeletal patterns and malocclusion but none have been universally adopted by teams providing orthognathic surgery in the UK. Using a standardised objective measure of a patient's condition is important both for service provision, treatment allocation, and other clinical governance domains. The Severity and Outcome Assessment tool (SOA) developed by the British Orthodontic Society (BOS) and British Association of Oral and Maxillofacial Surgeons (BAOMS) provides a standardised method of assessing patients throughout the orthognathic pathway and lends itself to case selection, resource allocation and auditing treatment outcomes. Read More

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http://dx.doi.org/10.1016/j.bjoms.2018.10.291DOI Listing
March 2019
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Socioeconomic and ethnic status of two- and three-year-olds undergoing dental extractions under general anaesthesia in Wolverhampton, 2011-2016.

Br Dent J 2019 Mar;226(5):349-353

Wolverhampton Special Care Dental Services, Pennfields Health Centre, Wolverhampton, UK.

Introduction Socioeconomic and ethnic status have in the past been implicated as possible causes of dental caries. Aims To assess the role that relative social depravation and ethnicity has on dental caries in two- and three-year-olds undergoing DGA in Wolverhampton. Design and methods Retrospective analysis of hospital records of 213 patients over a six-year period (2011-2016). Read More

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http://dx.doi.org/10.1038/s41415-019-0029-9DOI Listing

Peri-operative management of ophthalmic patients on anti-thrombotic agents: a literature review.

Eye (Lond) 2019 Mar 8. Epub 2019 Mar 8.

St. Paul's Eye Unit, Royal Liverpool University Hospital, Liverpool, L7 8XP, UK.

There is variability in the management of ophthalmic patients on anti-thrombotic agents (antiplatelets and anticoagulants) during the peri-operative period. A survey carried out in a UK teaching hospital on a cohort of ophthalmologists showed majority were comfortable with antiplatelet management but there was variability in managing patients on warfarin and direct oral anticoagulants (DOACs); 40% were unaware of existing guidelines. We aim to review the recommendations in the literature with regards to managing anti-thrombotic agents during the peri-operative period of ophthalmic surgery. Read More

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http://dx.doi.org/10.1038/s41433-019-0382-6DOI Listing
March 2019
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Long-term side effects of sleep apnea treatment with oral appliances: nature, magnitude and predictors of long-term changes.

Sleep Med 2018 Dec 29. Epub 2018 Dec 29.

Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada. Electronic address:

Objectives: Oral appliances for the treatment of obstructive sleep apnea (OSA) reduce upper airway collapse by advancing the mandible (OAm) and associated soft tissues. OAm are well tolerated but have side effects, mainly dental movement. It is not yet clear whether there are irreversible skeletal changes associated with treatment. Read More

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http://dx.doi.org/10.1016/j.sleep.2018.12.012DOI Listing
December 2018
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Acute interaction between oral glucose (75 g as Lucozade) and inorganic nitrate: decreased insulin clearance, but lack of blood pressure-lowering.

Br J Clin Pharmacol 2019 Mar 7. Epub 2019 Mar 7.

King's College London British Heart Foundation Centre, School of Cardiovascular Medicine and Sciences, Department of Clinical Pharmacology, London, UK.

Introduction: Dietary inorganic nitrate (NO ) lowers peripheral blood pressure (BP) in healthy volunteers, but lacks such effect in individuals with, or at risk of, type two diabetes mellitus. Whilst this is commonly assumed to be a consequence of chronic hyperglycaemia/hyperinsulinaemia, we hypothesised that acute physiological elevations in plasma [glucose]/[insulin] blunt the haemodynamic responses to NO ; a pertinent question for carbohydrate-rich Western diets.

Methods: We conducted an acute, randomised, placebo-controlled, double-blind, crossover study on the haemodynamic and metabolic effects of potassium nitrate (8 or 24 mmol KNO ) versus potassium chloride (KCl; placebo) administered 1 h prior to an oral glucose tolerance test in 33 healthy volunteers. Read More

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http://dx.doi.org/10.1111/bcp.13913DOI Listing
March 2019
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Ocrelizumab infusion experience in patients with relapsing and primary progressive multiple sclerosis: Results from the phase 3 randomized OPERA I, OPERA II, and ORATORIO studies.

Mult Scler Relat Disord 2019 May 28;30:236-243. Epub 2019 Jan 28.

McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA.

Background: Ocrelizumab is an infusible humanized monoclonal antibody that selectively depletes CD20 B cells. Infusion-related reactions (IRRs) were summarized from the OPERA I, OPERA II, and ORATORIO trials for relapsing and primary progressive multiple sclerosis (MS).

Methods: OPERA I and OPERA II were identical, randomized, double-blind, active-controlled trials that enrolled patients with relapsing MS (RMS). Read More

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http://dx.doi.org/10.1016/j.msard.2019.01.044DOI Listing
May 2019
2 Reads

Successful treatment with slow-release oral morphine following afentanyl-related overdose: A case report.

Subst Abus 2019 Mar 4:1-3. Epub 2019 Mar 4.

a British Columbia Centre on Substance Use , Vancouver , British Columbia , Canada.

Background: Overdose deaths as a result of untreated opioid use disorder (OUD) pose a major public health concern across North America. Although slow-release oral morphine (SROM) is increasingly used as an alternative option for the treatment of OUD, research on its efficacy among individuals exposed to illicit fentanyl or those with previous unsuccessful attempts with other opioid agonist therapies (OATs) is limited and controversial.

Case: We present a case of a 48-year-old male with severe OUD seeking treatment following a near-fatal fentanyl overdose. Read More

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https://www.tandfonline.com/doi/full/10.1080/08897077.2019.1
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http://dx.doi.org/10.1080/08897077.2019.1576086DOI Listing
March 2019
5 Reads

Trial design and baseline data for LIRA-PRIME: A randomized trial investigating the efficacy of liraglutide in controlling glycaemia in type 2 diabetes in a primary care setting.

Diabetes Obes Metab 2019 Mar 3. Epub 2019 Mar 3.

Middle East Institute of Health University Hospital, Bsalim, Lebanon.

Aims: Using a pragmatic approach, the LIRA-PRIME trial aims to address a knowledge gap by comparing efficacy in controlling glycaemia with glucagon-like peptide-1 analog liraglutide vs oral antidiabetic drugs (OADs) in patients with type 2 diabetes (T2D) uncontrolled with metformin monotherapy in primary care practice. We report the study design and patient baseline characteristics.

Materials And Methods: This 104-week, two-arm, open-label, active-controlled trial is active in 219 primary care practices across nine countries. Read More

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http://dx.doi.org/10.1111/dom.13682DOI Listing
March 2019
2 Reads

Metabolic effects of leptin receptor knockdown or reconstitution in adipose tissues.

Sci Rep 2019 Mar 1;9(1):3307. Epub 2019 Mar 1.

Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada.

The relative contribution of peripheral and central leptin signalling to the regulation of metabolism and the mechanisms through which leptin affects glucose homeostasis have not been fully elucidated. We generated complementary lines of mice with either leptin receptor (Lepr) knockdown or reconstitution in adipose tissues using Cre-lox methodology. Lepr knockdown mice were modestly lighter and had lower plasma insulin concentrations following an oral glucose challenge compared to controls, despite similar insulin sensitivity. Read More

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http://dx.doi.org/10.1038/s41598-019-39498-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397253PMC
March 2019
5.078 Impact Factor

Effects of two fast-setting pulp-capping materials on cell viability and osteogenic differentiation in human dental pulp stem cells: An in vitro study.

Arch Oral Biol 2019 Apr 20;100:100-105. Epub 2019 Feb 20.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Conservative Dentistry and Endodontics, West China School and Hospital of Stomatology, Sichuan University, Chengdu, 610041, China. Electronic address:

Objective: The purpose of this study was to compare the effects of two fast-setting pulp-capping materials, Biodentine (BD) and iRoot Fast Set (FS) root repair material, on the attachment, viability, migration, and differentiation of human dental pulp stem cells (hDPSCs).

Methods: A comparative study was conducted between BD and FS material disks. Scanning electron microscope (SEM) images were used to observe the attachment of hDPSCs on the disks. Read More

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http://dx.doi.org/10.1016/j.archoralbio.2019.02.014DOI Listing
April 2019
1.880 Impact Factor

Gradual dehydration affects the mechanical properties and bonding outcome of adhesives to dentin.

Dent Mater J 2019 Feb 28. Epub 2019 Feb 28.

Department of Oral Biological and Medical Sciences, Division of Biomaterials, Faculty of Dentistry, University of British Columbia.

This study evaluated the effects of dehydration on the mechanical properties of adhesive resins and dentin, and on the microtensile bond strength (µTBS) of adhesives. Third molars were randomly bonded with Clearfil Mega Bond (MB) or Clearfil SE Bond 2 (SE). After water-storage (37°C; 24 h), µTBS was obtained in 'wet' (tested after 5 min of removal from storage) and 'dehydrated' (tested after 10, 15 min and 24 h) conditions by a universal tester (crosshead speed: 1 mm/min). Read More

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http://dx.doi.org/10.4012/dmj.2018-142DOI Listing
February 2019

The Development of Oral Amphotericin B to Treat Systemic Fungal and Parasitic Infections: Has the Myth Been Finally Realized?

Pharmaceutics 2019 Feb 26;11(3). Epub 2019 Feb 26.

College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK S7N 2Z4, Canada.

Parenteral amphotericin B has been considered as first-line therapy in the treatment of systemic fungal and parasitic infections, however its use has been associated with a number of limitations including affordability, accessibility, and an array of systemic toxicities. Until very recently, it has been very challenging to develop a bioavailable formulation of amphotericin B due to its physical chemical properties, limited water and lipid solubility, and poor absorption. This perspective reviews several novel oral Amphotericin B formulations under development that are attempting to overcome these limitations. Read More

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http://dx.doi.org/10.3390/pharmaceutics11030099DOI Listing
February 2019
3 Reads

Misoprostol is superior to combined omeprazole-sucralfate for the treatment of equine gastric glandular disease.

Equine Vet J 2019 Feb 26. Epub 2019 Feb 26.

School of Veterinary Medicine and Science, University of Nottingham, Loughborough, UK.

Background: Previous studies have demonstrated a poor response to healing of gastric glandular lesions with oral omeprazole and other medications.

Objectives: To evaluate the efficacy of two novel treatments (misoprostol [M] and combined omeprazole-sucralfate [OS]) in horses for gastric glandular disease.

Study Design: Prospective, clinical study. Read More

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http://dx.doi.org/10.1111/evj.13087DOI Listing
February 2019
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Risk Assessment of Smokeless Tobacco among Oral Precancer and Cancer Patients in Eastern Developmental Region of Nepal

Asian Pac J Cancer Prev 2019 Feb 26;20(2):411-415. Epub 2019 Feb 26.

Department of Oral Medicine and Radiology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal. Email:

Background: Oral potentially malignant disorders (OPMDs) and oral cancer (OC) are preventable oral mucosal diseases prevalent in Asian region. This epidemiological study aims to identify oral potentially malignant disorders (OPMDs) and oral cancer (OC), confirm histopathologically, and treat or refer these cases among the population of Eastern Development Region (EDR) of Nepal. It also attempts to assess the risk factors associated in order to compare dose–response measurements of oral habits in these patients. Read More

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http://dx.doi.org/10.31557/APJCP.2019.20.2.411DOI Listing
February 2019
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Periodontal diagnosis in the context of the BSP implementation plan for the 2017 classification system of periodontal diseases and conditions: presentation of a patient with a history of periodontal treatment.

Br Dent J 2019 Feb;226(4):265-267

Department of Oral Surgery, The School of Dentistry, University of Birmingham, Birmingham, UK.

This case report is the fourth in a series that illustrates the application of the BSP implementation plan for diagnosing periodontitis patients according to the 2017 classification. It demonstrates the diagnostic approach and disease classification for a previously treated patient who presented with a diagnosis of unstable generalised periodontitis; stage IV, grade C. We describe a case of a 49-year-old patient who attended with a history of periodontal treatment over several years. Read More

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http://dx.doi.org/10.1038/s41415-019-0015-2DOI Listing
February 2019

Risperidone adjunctive therapy duration in the maintenance treatment of bipolar I disorder: A post hoc analysis.

J Affect Disord 2019 03 5;246:861-866. Epub 2019 Jan 5.

Department of Psychiatry, University of British Columbia; Mood Disorders Centre of Excellence, University of British Columbia, 2255, Wesbrook Mall, Vancouver, BC V6T 2A1, Canada. Electronic address:

Background: Risperidone, an atypical antipsychotic medication, is recommended as a first line treatment for acute mania in patients with bipolar disorder I (BD I). It is unknown if continuing treatment with risperidone adjunct to lithium or valproate after remission of the manic episode offers additional benefit in prevention of mood episode relapse.

Methods: A post-hoc subgroup analysis was conducted using data from a 52-week, double-blind, placebo controlled trial involving 93 patients treated with oral risperidone adjunct to mood stabilizer, randomized to arms discontinuing risperidone at entry ("0-week arm"), 24 weeks after entry ("24-week arm") or continuing risperidone ("52-week arm"). Read More

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http://dx.doi.org/10.1016/j.jad.2019.01.003DOI Listing
March 2019
1 Read