161,447 results match your criteria British Journal Of Management[Journal]


Factors related to heavy drinking between British Columbia Asian adolescents and South Korean adolescents.

J Spec Pediatr Nurs 2020 May 27:e12296. Epub 2020 May 27.

Stigma and Resilience Among Vulnerable Youth Centre, School of Nursing, University of British Columbia, Vancouver, British Columbia, Canada.

Purpose: The aim of this study is to compare the factors related to heavy drinking among British Columbia (BC) Asian adolescents and South Korean adolescents.

Design And Methods: A cross-sectional descriptive design was used. Participants were 72,422 adolescents (12,382 BC Asian adolescents and 60,040 South Korean adolescents) from the 2018 BC Adolescent Health Survey and the 2018 Korean Youth Risk Behavior Web-Based Survey. Read More

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http://dx.doi.org/10.1111/jspn.12296DOI Listing

Large-scale implementation of a pragmatic atrial fibrillation screening program in canadian community practice.

Pacing Clin Electrophysiol 2020 May 27. Epub 2020 May 27.

Université Laval, Quebec City, Canada.

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http://dx.doi.org/10.1111/pace.13966DOI Listing

Epithelial cell dysfunction, a major driver of asthma development.

Allergy 2020 May 27. Epub 2020 May 27.

University of Groningen, University Medical Center Groningen, Department of Pathology&Medical Biology GRIAC research Institute, Groningen, The Netherlands.

Airway epithelial barrier dysfunction is frequently observed in asthma and may have important implications. The physical barrier function of the airway epithelium is tightly interwoven with its immunomodulatory actions, while abnormal epithelial repair responses may contribute to remodelling of the airway wall. We propose that abnormalities in the airway epithelial barrier play a crucial role in the sensitization to allergens and pathogenesis of asthma. Read More

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http://dx.doi.org/10.1111/all.14421DOI Listing

A risk assessment tool for predicting fragility fractures and mortality in the elderly.

J Bone Miner Res 2020 May 27. Epub 2020 May 27.

Osteoporosis and Bone Biology, Garvan Institute of Medical Research, Sydney, Australia.

Existing fracture risk assessment tools are not designed to predict fracture-associated consequences, possibly contributing to the current under-management of fragility fractures worldwide. We aimed to develop a risk assessment tool for predicting the conceptual risk of fragility fractures and consequences. The study involved 8965 people aged ≥60 years from the Dubbo Osteoporosis Epidemiology Study and the Canadian Multicentre Osteoporosis Study. Read More

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http://dx.doi.org/10.1002/jbmr.4100DOI Listing

High mercury levels in Antarctic toothfish Dissostichus mawsoni from the Southwest Pacific sector of the Southern Ocean.

Environ Res 2020 May 16;187:109680. Epub 2020 May 16.

University of Coimbra, MARE - Marine and Environmental Sciences Centre, Department of Life Sciences, 3000-456, Coimbra, Portugal; British Antarctic Survey, Natural Environment Research Council, High Cross, Madingley Road, CB3 0ET, Cambridge, UK.

Mercury is a bioaccumulating toxic pollutant which can reach humans through the consumption of contaminated food (e.g. marine fish). Read More

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http://dx.doi.org/10.1016/j.envres.2020.109680DOI Listing

Reply by Authors.

J Urol 2020 May 27:101097JU000000000000079803. Epub 2020 May 27.

Decipher Biosciences Inc., Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1097/JU.0000000000000798.03DOI Listing

Translating 'protein foods' from the new Canada's Food Guide to consumers: Knowledge gaps and recommendations.

Appl Physiol Nutr Metab 2020 May 27. Epub 2020 May 27.

University of Manitoba , Room 209 Human Ecology , Department of Human Nutritional Sciences , Winnipeg, Manitoba, Canada , R3T 2N2 ;

The revised version of Canada's Food Guide, released in January 2019, issued new guidance by combining meat and alternatives with milk and alternatives into a single group called 'protein foods' and emphasized selecting plant-based foods from this category more often. Though the changes represent a simple depiction of a healthy plate, the new Food Guide has opened knowledge gaps about 'protein foods' and exposed new concerns about the interpretation and implementation of the Food Guide among vulnerable groups, particularly children and the elderly. To address key knowledge and research gaps, nutrition leaders need to reach a consensus on key messages to best inform the development of tools and resources to support practitioners in translating messages to consumers, including foodservice standards. Read More

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http://dx.doi.org/10.1139/apnm-2020-0192DOI Listing

Diagnostic Accuracy of Non-Invasive Thermal Evaluation of Ventriculoperitoneal Shunt Flow in Shunt Malfunction: A Prospective, Multi-Site, Operator-Blinded Study.

Neurosurgery 2020 May 27. Epub 2020 May 27.

Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

Background: Thermal flow evaluation (TFE) is a non-invasive method to assess ventriculoperitoneal shunt function. Flow detected by TFE is a negative predictor of the need for revision surgery. Further optimization of testing protocols, evaluation in multiple centers, and integration with clinical and imaging impressions prompted the current study. Read More

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http://dx.doi.org/10.1093/neuros/nyaa128DOI Listing

The authors reply.

Pediatr Crit Care Med 2020 May 27. Epub 2020 May 27.

Khoo Teck Puat-National University Children's Medical Institute, National University Hospital, Singapore, and Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Pediatric Intensive Care Unit, Department of Women's and Children's Health, University Hospital of Padua, Padua, Italy Sungkyunkwan University, Samsung Medical Center, Seoul, Republic of Korea; BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1097/PCC.0000000000002464DOI Listing

Comparison of Treatment Outcomes after Collagenase Injection and Percutaneous Needle Fasciotomy for Dupuytren's Contracture: Objective and Subjective Comparisons with a 3-Year Follow-Up.

Authors:
Yoshihiro Abe

Plast Reconstr Surg 2020 Jun;145(6):1464-1474

Ichihara City, Japan From the Department of Orthopedic Surgery, Chiba Rosai Hospital.

Background: This study compared the effectiveness of injectable collagenase clostridium histolyticum and percutaneous needle fasciotomy in the treatment of Dupuytren's contracture.

Methods: Patients with a total passive extension deficit of 30 degrees or more in a single digital ray were enrolled and assigned randomly to receive either collagenase clostridium histolyticum injections or percutaneous needle fasciotomy. Preoperative severity of proximal interphalangeal joint contracture for Dupuytren's disease was classified according to the British Society for Surgery of the Hand as less than 30 degrees (stage I) or 30 degrees or more (stage II). Read More

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http://dx.doi.org/10.1097/PRS.0000000000006828DOI Listing

Mobile Personal Healthcare System for Non-Invasive, Pervasive and Continuous Blood Pressure Monitoring: A Feasibility Study.

JMIR Mhealth Uhealth 2020 Apr 26. Epub 2020 Apr 26.

Departments of Neurosciences and Human Genetics, and Rio Grande Valley Alzheimer´s Disease Resource Center for Minority Aging Research, University of Texas Rio Grande Valley, Brownsville, US.

Background: Smartphone-based blood pressure (BP) monitor using photoplethysmogram (PPG) technology has emerged as a promising approach to empower users with self-monitoring for effective diagnosis and control of hypertension (HT).

Objective: This study aimed to develop a mobile personal healthcare system for non-invasive, pervasive, and continuous estimation of BP level and variability to be user-friendly to elderly.

Methods: The proposed approach was integrated by a self-designed cuffless, calibration-free, wireless and wearable PPG-only sensor, and a native purposely-designed smartphone application using multilayer perceptron machine learning techniques from raw signals. Read More

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http://dx.doi.org/10.2196/18012DOI Listing

Buoctapa-alkyl-NHS for metalloradiopeptide preparation.

Dalton Trans 2020 May 27. Epub 2020 May 27.

Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, British Columbia V6T 1Z1, Canada.

The peptide is an important class of biological targeting molecule; herein, a new bifunctional octadentate non-macrocyclic H4octapa, tBu4octapa-alkyl-NHS, which is compatible with solid-phase peptide synthesis and thus useful for radiopeptide preparation, has been synthesized. To preserve denticity, the alkyl-N-hydroxylsuccinimide linker was covalently attached to the methylene-carbon on one of the acetate arms, yielding a chiral carbon center. According to density-functional theory (DFT) calculations using [Lu(octapa-alkyl-benzyl-ester)]- as a simulation model, the chirality has minimal effects on the complex geometry; regardless of the S-/R-stereochemistry, DFT calculations revealed two possible geometric isomers, distorted bicapped trigonal antiprism (DBTA) and distorted square antiprism (DSA), due to the asymmetry in the chelator. Read More

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http://dx.doi.org/10.1039/d0dt00845aDOI Listing

Inclusion of Mechanical Ventilation in Severity Staging of Tuberculous Meningitis Improves Outcome Prediction.

Am J Trop Med Hyg 2020 May 26. Epub 2020 May 26.

Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Patients with tuberculous meningitis (TBM) in any stage of the British Medical Research Council (BMRC) scale, if requiring mechanical ventilation (MV), are likely to have a poor outcome. We report the usefulness of BMRC, BMRC-MV, and BMRC-hydrocephalus (BMRC-HC) staging, and Haydarpasa Meningitis Severity Index (HAMSI) scoring in predicting the outcome of TBM. One hundred ninety-seven TBM patients were analyzed from a prospective maintained TBM registry. Read More

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http://dx.doi.org/10.4269/ajtmh.20-0077DOI Listing

Evolutionary links between intra- and extracellular acid-base regulation in fish and other aquatic animals.

J Exp Zool A Ecol Integr Physiol 2020 May 26. Epub 2020 May 26.

Department of Zoology, University of British Columbia, Vancouver, Canada.

The acid-base relevant molecules carbon dioxide (CO ), protons (H ), and bicarbonate (HCO ) are substrates and end products of some of the most essential physiological functions including aerobic and anaerobic respiration, ATP hydrolysis, photosynthesis, and calcification. The structure and function of many enzymes and other macromolecules are highly sensitive to changes in pH, and thus maintaining acid-base homeostasis in the face of metabolic and environmental disturbances is essential for proper cellular function. On the other hand, CO , H , and HCO have regulatory effects on various proteins and processes, both directly through allosteric modulation and indirectly through signal transduction pathways. Read More

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http://dx.doi.org/10.1002/jez.2367DOI Listing

Hot spots, Risk Factors and Management of Polio virus in Pakistan.

J Med Virol 2020 May 26. Epub 2020 May 26.

Department of Biosciences,, COMSATS University Islamabad (CUI), Islamabad, Pakistan.

Poliomyelitis is a central nervous system disease caused by poliovirus which effects the spinal cord and leads to paralysis. There are three types of Wild Polio Viruses (WPV) -1, 2 and 3 out of which type-2 has been declared as eradicated from world in 2015. Pakistan, Afghanistan and Nigeria are only three countries in world where polio status is still endemic. Read More

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http://dx.doi.org/10.1002/jmv.26058DOI Listing

Dementia and revivalist Islam: New perspectives to understanding dementia and tackling stigma.

J Eval Clin Pract 2020 May 26. Epub 2020 May 26.

Primary Care Centre Versus Arthritis, School of Primary, Community and Social Care, Keele University, Staffordshire, UK.

The notion of stigma and its influence on the understanding of dementia has commonly been recognized as a great challenge to seeking healthcare services for South Asians in England. The aim of this commentary is to examine how Muslims view, understand and tackle dementia stigma in the context of revivalist Islam, especially among Bangladeshi Muslims within their British communities. This article reflects on the interrelationship between dementia and revivalist Islam among Bangladeshi family caregivers and addresses the question of how revivalist Islam is a significant source of understanding dementia and tackling stigma. Read More

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http://dx.doi.org/10.1111/jep.13412DOI Listing

Communicating risks to drinkers: testing alcohol labels with a cancer warning and national drinking guidelines in Canada.

Can J Public Health 2020 May 26. Epub 2020 May 26.

Canadian Institute for Substance Use Research, University of Victoria, Victoria, British Columbia, Canada.

Objective: To test whether alcohol labels with a cancer warning and national drinking guidelines are an effective tool for supporting more informed and safer alcohol consumption among drinkers.

Methods: Using a quasi-experimental design, pre-post surveys were conducted with 1647 cohort participants systematically selected in liquor stores in two matched sites in Canada in 2017-2018. Enhanced labels designed according to best practices for effective product labels were applied to alcohol containers in the liquor store in the intervention site for one month, and usual practice continued in the comparison site. Read More

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http://dx.doi.org/10.17269/s41997-020-00320-7DOI Listing

Constructing a Human Atrial Fibre Atlas.

Ann Biomed Eng 2020 May 26. Epub 2020 May 26.

School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.

Atrial anisotropy affects electrical propagation patterns, anchor locations of atrial reentrant drivers, and atrial mechanics. However, patient-specific atrial fibre fields and anisotropy measurements are not currently available, and consequently assigning fibre fields to atrial models is challenging. We aimed to construct an atrial fibre atlas from a high-resolution DTMRI dataset that optimally reproduces electrophysiology simulation predictions corresponding to patient-specific fibre fields, and to develop a methodology for automatically assigning fibres to patient-specific anatomies. Read More

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http://dx.doi.org/10.1007/s10439-020-02525-wDOI Listing

MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men.

Eur J Appl Physiol 2020 May 26. Epub 2020 May 26.

Discipline of Nutrition, School of Medical Sciences, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag, 92019, Auckland, New Zealand.

Purpose: Excess production of reactive oxygen species (ROS) from the mitochondria can promote mitochondrial dysfunction and has been implicated in the development of a range of chronic diseases. As such there is interest in whether mitochondrial-targeted antioxidant supplementation can attenuate mitochondrial-associated oxidative stress. We investigated the effect of MitoQ and CoQ10 supplementation on oxidative stress and skeletal muscle mitochondrial ROS levels and function in healthy middle-aged men. Read More

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http://dx.doi.org/10.1007/s00421-020-04396-4DOI Listing

Improved adaptation to physical stress in mice overexpressing SUR2A is associated with changes in the pattern of Q-T interval.

Pflugers Arch 2020 May 27. Epub 2020 May 27.

Department of Basic and Clinical Sciences, University of Nicosia Medical School, Nicosia, Cyprus.

The purpose of this study was to determine whether increased expression of SUR2A, a regulatory subunit of sarcolemmal ATP-sensitive K (K) channels, improves adaptation to physical stress and regulates cardiac electrophysiology in physical stress. All experiments have been done on transgenic mice in which SUR2A expression was controlled by cytomegalovirus immediate-early (CMV) promoter (SUR2A) and their littermate wild-type controls (WT). The levels of mRNA in heart tissue were measured by real-time RT-PCR. Read More

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http://dx.doi.org/10.1007/s00424-020-02401-5DOI Listing

Causal Attributions in an Australian Aboriginal Family With Marfan Syndrome: A Qualitative Study.

Front Genet 2020 7;11:461. Epub 2020 May 7.

Translational Genomics Group, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia.

Causal attributions are important determinants of how health threats are processed and affect health-related behaviors. To date, there has been no research on causal attributions in genetic conditions in Aboriginal Australians. Forty members of a large Aboriginal Australian family with Marfan syndrome (MFS) were invited to participate in an ethically approved study exploring causal attributions, including perceived causes of phenotypic variability within the family. Read More

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http://dx.doi.org/10.3389/fgene.2020.00461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7221064PMC

A Binary-Based Matrix Model for Corolla Symmetry and Its Variational Significance.

Front Plant Sci 2020 28;11:416. Epub 2020 Apr 28.

College of Forestry, Nanjing Forestry University, Nanjing, China.

Floral symmetry (corolla symmetry) has important biological significance in plant genetics and evolution. However, it is often multi-dimensional and difficult to quantify. Here, we constructed a multi-dimensional data matrix [X Y Z] by extracting three qualitative variables with binary properties (X: corolla regularity of interval and coplanarity; Y: petal regularity of shape and size; Z: petal local regularity of curling and wrinkle) from different dimensions of petals (overall to individual, and then to the local): all petals (corolla), individual petals, and local areas of petals. Read More

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http://dx.doi.org/10.3389/fpls.2020.00416DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198884PMC

Cleavage of Desmosomal Cadherins Promotes γ-Catenin Degradation and Benefits Wnt Signaling in Coxsackievirus B3-Induced Destruction of Cardiomyocytes.

Front Microbiol 2020 8;11:767. Epub 2020 May 8.

Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.

Coxsackievirus B3 (CVB3) is the primary etiologic agent of viral myocarditis, a major heart disease that occurs predominantly in children and young adolescents. In the heart, intercalated disks (ICD) are important structural formations that connect adjacent cardiomyocytes to maintain cardiac architecture and mediate signal communication. Deficiency in ICD components, such as desmosome proteins, leads to heart dysfunction. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225294PMC

Influences of landscape change and winter severity on invasive ungulate persistence in the Nearctic boreal forest.

Sci Rep 2020 May 26;10(1):8742. Epub 2020 May 26.

Former address: InnoTech Alberta, Bag 4000, Vegreville, Alberta, T9C1T4, Canada.

Climate and landscape change are drivers of species range shifts and biodiversity loss; understanding how they facilitate and sustain invasions has been empirically challenging. Winter severity is decreasing with climate change and is a predicted mechanism of contemporary and future range shifts. For example, white-tailed deer (Odocoileus virginianus) expansion is a continental phenomenon across the Nearctic with ecological consequences for entire biotic communities. Read More

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http://dx.doi.org/10.1038/s41598-020-65385-3DOI Listing

Epithelial-interleukin-1 inhibits collagen formation by airway fibroblasts: Implications for asthma.

Sci Rep 2020 May 26;10(1):8721. Epub 2020 May 26.

Centre for Heart Lung Innovation, University of British Columbia (UBC), Vancouver, B.C., Canada.

In asthma, the airway epithelium has an impaired capacity to differentiate and plays a key role in the development of airway inflammation and remodeling through mediator release. The study objective was to investigate the release of (IL)-1 family members from primary airway epithelial-cells during differentiation, and how they affect primary airway fibroblast (PAF)-induced inflammation, extracellular matrix (ECM) production, and collagen I remodeling. The release of IL-1α/β and IL-33 during airway epithelial differentiation was assessed over 20-days using air-liquid interface cultures. Read More

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http://dx.doi.org/10.1038/s41598-020-65567-zDOI Listing

Factors associated with interest in bacterial sexually transmitted infection vaccines at two large sexually transmitted infection clinics in British Columbia, Canada.

Sex Transm Infect 2020 May 26. Epub 2020 May 26.

British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada.

Objective: To explore sexually transmitted infection (STI) clinic client attitudes and preferences towards STI vaccines and STI vaccine programming in an urban clinic setting.

Methods: A 31-item questionnaire was administered during check-in by clinic clerical staff at two STI clinics in Vancouver, Canada. Demographic characteristics and preferences were summarised descriptively. Read More

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http://dx.doi.org/10.1136/sextrans-2019-054311DOI Listing

Structuring a UK military role 1 medical treatment facility for a sustained mobile exercise in a hot desert environment: UK military exercise SAIF SAREEA 3.

BMJ Mil Health 2020 May 25. Epub 2020 May 25.

5 Armoured Medical Regiment, British Army, Catterick Garrison, UK

Exercise SAIF SAREEA 3 (SS3) is a triservice combined joint training military Exercise between the UK and the Omani Armed forces. SS3 represented a rare opportunity to exercise a complete role 1 medical reception station (MRS) in a tented platform for a prolonged period providing 'real life support', as opposed to an exercise without casualties. This article is a discursive paper making recommendations for amendments to the established structure for the MRS within static high-temperature deployments. Read More

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http://dx.doi.org/10.1136/bmjmilitary-2019-001361DOI Listing

Radical cystectomy improves survival in patients with stage T1 squamous cell carcinoma and neuroendocrine carcinoma of the urinary bladder.

Eur J Surg Oncol 2020 May 12. Epub 2020 May 12.

Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada.

Background: Radical cystectomy (RC) is often performed for T1 variant histology bladder cancer (VHBC), based on weak clinical evidence. We tested for cancer specific survival (CSS) differences after RC between T1 VHBC vs. urothelial carcinoma of the urinary bladder (UBC). Read More

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http://dx.doi.org/10.1016/j.ejso.2020.05.006DOI Listing

Shark ecotourism in Mexico: Scientific research, conservation, and contribution to a Blue Economy.

Adv Mar Biol 2020 26;85(1):71-92. Epub 2019 Aug 26.

Ecosistemas y Conservación: Proazul Terrestre A.C., Héroes de Independencia, La Paz, BCS, Mexico.

Shark ecotourism has the potential to contribute significantly to local and national economies and conservation, though this depends on a concerted effort to implement evidence-based management. Sharks are key attractions at some of the most important marine ecotourism sites throughout Mexico, focusing particularly on whale sharks, white sharks, hammerhead sharks, and several other reef-associated and pelagic species. This generates important employment opportunities and millions of USD in revenue, but truly implementing ecotourism requires that education and conservation be a part of activities and that these benefit local communities, so that the industry can be socially, economically and ecologically sustainable. Read More

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http://dx.doi.org/10.1016/bs.amb.2019.08.003DOI Listing

Lung point-of-care ultrasound, an opportunity to improve patient care and patient-oriented outcomes.

CJEM 2020 May;22(3):271-272

Department of Emergency Medicine, Dalhousie University, Saint John Regional Hospital, Saint John, NB.

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http://dx.doi.org/10.1017/cem.2020.52DOI Listing

Mental Disorders in Firefighters Following Large-Scale Disaster.

Disaster Med Public Health Prep 2020 May 27:1-14. Epub 2020 May 27.

Centre for Response-Based Care, Kamloops, BC, Canada.

Firefighting service is known to involve high rates of exposure to potentially traumatic situations, and research on mental health in firefighting populations is of critical importance in understanding the impact of occupational exposure. To date, the literature concerning prevalence of trauma-related mental disorders such as posttraumatic stress disorder (PTSD) has not distinguished between symptomology associated routine duty-related exposure and exposure to large-scale disaster. The present systematic review synthesizes a heterogeneous cross-national literature on large-scale disaster exposure in firefighters and provides support for the hypothesis that the prevalence of PTSD, major depressive disorder, and anxiety disorders are elevated in firefighters compared with rates observed in the general population. Read More

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http://dx.doi.org/10.1017/dmp.2020.61DOI Listing

Enteroviral and herpes simplex virus central nervous system infections in infants < 90 days old: a Paediatric Investigators' Collaborative Network on Infections in Canada (PICNIC) study.

BMC Pediatr 2020 May 26;20(1):252. Epub 2020 May 26.

Department of Pediatrics, University of Alberta, 4-590 ECHA, 11405-87 Ave, Edmonton, AB, T6G 1C9, Canada.

Background: The relative contribution of viruses to central nervous system (CNS) infections in young infants is not clear. For viral CNS infections, there are limited data on features that suggest HSV etiology or on predictors of unfavorable outcome.

Methods: In this cross-sectional retrospective study, seven centers from the Pediatric Investigators Collaborative Network on Infections in Canada identified infants < 90 days of age with CNS infection proven to be due to enterovirus (EV) or herpes simplex virus (HSV) January 1, 2013 through December 31, 2014. Read More

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http://dx.doi.org/10.1186/s12887-020-02151-4DOI Listing

Consensus guideline for the diagnosis and treatment of tetrahydrobiopterin (BH) deficiencies.

Orphanet J Rare Dis 2020 May 26;15(1):126. Epub 2020 May 26.

Division of Child Neurology and Metabolic Disorders, University Children's Hospital, Heidelberg, Germany.

Background: Tetrahydrobiopterin (BH) deficiencies comprise a group of six rare neurometabolic disorders characterized by insufficient synthesis of the monoamine neurotransmitters dopamine and serotonin due to a disturbance of BH biosynthesis or recycling. Hyperphenylalaninemia (HPA) is the first diagnostic hallmark for most BH deficiencies, apart from autosomal dominant guanosine triphosphate cyclohydrolase I deficiency and sepiapterin reductase deficiency. Early supplementation of neurotransmitter precursors and where appropriate, treatment of HPA results in significant improvement of motor and cognitive function. Read More

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http://dx.doi.org/10.1186/s13023-020-01379-8DOI Listing

Association of High-Density Lipoprotein Cholesterol With Cognitive Function: Findings From the PROspective Study of Pravastatin in the Elderly at Risk.

J Aging Health 2020 May 27:898264320916959. Epub 2020 May 27.

Department of Epidemiology, Mailman School of Public Health, Columbia University, NYC, NY.

We aimed to examine whether variability in high-density lipoprotein cholesterol (HDL-c) over time was associated with cognitive function. We conducted a post hoc analysis of the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) trial. Our sample included 4,428 participants with at least two repeated HDL-c measures between Months 3 and 24 postbaseline and with cognitive assessments at Month 30. Read More

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http://dx.doi.org/10.1177/0898264320916959DOI Listing

Development and Validation of Caregiver Risk Evaluation (CaRE): A New Algorithm to Screen for Caregiver Burden.

J Appl Gerontol 2020 May 26:733464820920102. Epub 2020 May 26.

University of Waterloo, Ontario, Canada.

The main objective was to develop a decision-support tool to assess the risk of caregiver burden, the Caregiver Risk Evaluation (CaRE) algorithm. Home care clients were assessed using the Resident Assessment Instrument for Home Care (RAI-HC). Their caregiver completed the 12-item Zarit Burden Interview (ZBI), the main dependent measure, which was linked to the RAI-HC. Read More

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http://dx.doi.org/10.1177/0733464820920102DOI Listing

Out-of-School Vision Screening in North India: Estimating the Magnitude of Need.

Ophthalmic Epidemiol 2020 May 27:1-4. Epub 2020 May 27.

Department of Ophthalmology, University of British Columbia and Program Director, SEVA Canada.

: Few studies have examined the extent to which school-based vision screening is sufficient to achieve universal coverage among school-aged children in India.: A rural administrative region ('Block') was examined. Government records provided the total population of the rural Block, the proportion of school-aged children, and school authorities in the Block provided the number of enrolled students. Read More

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http://dx.doi.org/10.1080/09286586.2020.1766513DOI Listing

Greater Well-Being in More Physically Active Cancer Patients Who Are Enrolled in Supportive Care Services.

Integr Cancer Ther 2020 Jan-Dec;19:1534735420921439

University of California San Diego, La Jolla, CA, USA.

Cancers are one of the leading causes of mortality worldwide. Cancer patients are increasingly seeking integrative care clinics to promote their health and well-being during and after treatment. To examine relationships between physical activity (PA) and quality of life (QoL) in a sample of cancer patients enrolling in integrative care in a supportive care clinic. Read More

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http://dx.doi.org/10.1177/1534735420921439DOI Listing

Neutrophils Modulate Fibroblast Function and Promote Healing and Scar Formation after Murine Myocardial Infarction.

Int J Mol Sci 2020 May 23;21(10). Epub 2020 May 23.

Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, 52074 Aachen, Germany.

Aim: Recruitment of neutrophils to the heart following acute myocardial infarction (MI) initiates inflammation and contributes to adverse post-infarct left ventricular (LV) remodeling. However, therapeutic inhibition of neutrophil recruitment into the infarct zone has not been beneficial in MI patients, suggesting a possible dual role for neutrophils in inflammation and repair following MI. Here, we investigate the effect of neutrophils on cardiac fibroblast function following MI. Read More

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http://dx.doi.org/10.3390/ijms21103685DOI Listing

Estimating Lower Extremity Running Gait Kinematics with a Single Accelerometer: A Deep Learning Approach.

Sensors (Basel) 2020 May 22;20(10). Epub 2020 May 22.

Menrva Research Group, Schools of Mechatronic Systems Engineering & Engineering Science, Simon Fraser University, Metro Vancouver, BC V5A 1S6, Canada.

Abnormal running kinematics are associated with an increased incidence of lower extremity injuries among runners. Accurate and unobtrusive running kinematic measurement plays an important role in the detection of gait abnormalities and the prevention of injuries among runners. Inertial-based methods have been proposed to address this need. Read More

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http://dx.doi.org/10.3390/s20102939DOI Listing

Multi-Omics Analysis of Diabetic Heart Disease in the Model Reveals Potential Targets for Treatment by a Longevity-Associated Gene.

Cells 2020 May 21;9(5). Epub 2020 May 21.

Bristol Medical School: Translational Health Sciences, University of Bristol, Bristol BS2 8HW UK.

Characterisation of animal models of diabetic cardiomyopathy may help unravel new molecular targets for therapy. Long-living individuals are protected from the adverse influence of diabetes on the heart, and the transfer of a longevity-associated variant (LAV) of the human gene protects cardiac function in the mouse model. This study aimed to determine the effect of therapy on the metabolic phenotype (ultra-high-performance liquid chromatography-mass spectrometry, UHPLC-MS) and cardiac transcriptome (next-generation RNAseq) in mice. Read More

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http://dx.doi.org/10.3390/cells9051283DOI Listing

Work Related Musculoskeletal Pain in Golf Caddies-Johannesburg, South Africa.

Int J Environ Res Public Health 2020 May 21;17(10). Epub 2020 May 21.

Epidemiology and Surveillance Section, National Institute for Occupational Health (NIOH), A Division of National Health Laboratory Service (NHLS), Johannesburg 2000, South Africa.

Golf is an important and growing industry in South Africa that currently fosters the creation of an informal job sector of which little is known about the health and safety risks. The purpose of the study is to investigate the prevalence and significance of musculoskeletal pain in male caddies compared to other golf course employees while holding contributing factors such as socioeconomic status, age, and education constant. Cross-sectional data were collected and analyzed from a convenience sample of 249 caddies and 74 non-caddies from six golf courses in Johannesburg, South Africa. Read More

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http://dx.doi.org/10.3390/ijerph17103617DOI Listing

A Validated Reverse Phase-Ultra-Performance Liquid Chromatography Method for the Determination of Gemifloxacin Mesylate in Bulk and its Pharmaceutical Preparation.

Turk J Pharm Sci 2019 Mar 31;16(1):8-13. Epub 2018 Dec 31.

The British University in Egypt, Faculty of Pharmacy, The Center for Drug Research and Development, Cairo, Egypt.

Objectives: Gemifloxacin Mesylate is a fourth generation fluoroquinolone antibacterial agent. A simple, accurate, and precise reversed phase (RP)-ultra performance liquid chromatography (UPLC) method was developed and validated for short time analysis of Gemifloxacin Mesylate in its bulk and pharmaceutical preparation.

Materials And Methods: The optimum separation was achieved at 0. Read More

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http://dx.doi.org/10.4274/tjps.04934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227989PMC

Our First Month of Delivering the Prostate Cancer Diagnostic Pathway within the Limitations of COVID-19 Using Local Anaesthetic Transperineal Biopsy.

BJU Int 2020 May 26. Epub 2020 May 26.

Department of Urology, Guy's at St Thomas' Hospitals, London, UK.

The COVID-19 pandemic is impacting all urological cancer services. On March 19 the British Association of Urological Surgeons (BAUS) provided pragmatic guidance for prostate cancer diagnostic services (Table 1).(1). Read More

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http://dx.doi.org/10.1111/bju.15120DOI Listing

Contribution of Immunoscore and Molecular Features to Survival Prediction in Stage III Colon Cancer.

JNCI Cancer Spectr 2020 Jun 5;4(3):pkaa023. Epub 2020 Apr 5.

Division of Oncology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.

Background: The American Joint Committee on Cancer staging and other prognostic tools fail to account for stage-independent variability in outcome. We developed a prognostic classifier adding Immunoscore to clinicopathological and molecular features in patients with stage III colon cancer.

Methods: Patient (n = 559) data from the FOLFOX arm of adjuvant trial NCCTG N0147 were used to construct Cox models for predicting disease-free survival (DFS). Read More

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http://dx.doi.org/10.1093/jncics/pkaa023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236783PMC

Course 2 - creating a specialty registrars procedure course.

Future Healthc J 2020 Feb;7(Suppl 1):s101

Queen Alexandra Hospital, Portsmouth, UK.

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http://dx.doi.org/10.7861/fhj.7.1.s101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241149PMC
February 2020

Selective Cyclized α-Melanocyte-Stimulating Hormone Derivative with Multiple -Methylations for Melanoma Imaging with Positron Emission Tomography.

ACS Omega 2020 May 7;5(19):10767-10773. Epub 2020 May 7.

Department of Molecular Oncology, BC Cancer, 675 W 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.

In this study, we designed and evaluated a novel α-melanocyte-stimulating hormone derivative with four -methylations for melanocortin 1 receptor-targeted melanoma imaging with positron emission tomography (PET). The resulting peptide, DOTA-Pip-Nle-Cyclo[Asp--Me-His-d-Phe--Me-Arg--Me-Trp--Me-Lys]αMSH-NH (CCZ01099), showed high receptor selectivity, greatly improved stability, and rapid internalization. [Ga]Ga-CCZ01099 showed clear tumor visualization and excellent tumor-to-normal tissue contrast with PET imaging in a preclinical melanoma model. Read More

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http://dx.doi.org/10.1021/acsomega.0c00310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240809PMC

Splenectomy for Solitary Splenic Metastasis in Recurrent Papillary Thyroid Cancer. A Case Report and Literature Review.

Case Rep Oncol Med 2020 4;2020:2084847. Epub 2020 May 4.

Department of Surgical Oncology, American British Cowdray Medical Center, Mexico City, Mexico.

Thyroid cancer is the most common endocrine malignancy, presenting with 23 500 new cases per year in the United States. About 7-23% of the patients will present recurrent metastases disease during follow-up. The classic variant of papillary carcinoma is less aggressive compared to its other variants like diffuse sclerosing, tall cell or columnar cell, and insular variants, and the sites to which this metastasizes is already well identified. Read More

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http://dx.doi.org/10.1155/2020/2084847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232720PMC

State-dependent foraging by caribou with different nutritional requirements.

J Mammal 2020 May 2;101(2):544-557. Epub 2020 Mar 2.

Natural Resources and Environmental Studies, University of Northern British Columbia, Prince George, British Columbia, Canada.

Foraging by animals is hypothesized to be state-dependent, that is, varying with physiological condition of individuals. State often is defined by energy reserves, but state also can reflect differences in nutritional requirements (e.g. Read More

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http://dx.doi.org/10.1093/jmammal/gyaa003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236907PMC