1,324 results match your criteria British Journal Of Guidance & Counselling[Journal]


Assigning Medical Students Learning Goals: Do They Do It, and What Happens When They Don't?

Teach Learn Med 2019 Apr 16:1-8. Epub 2019 Apr 16.

a Wilson Centre , University Health Network ; Faculty of Medicine , University of Toronto , Toronto , Ontario , Canada.

Theory: Medical curricula now include more time for trainees to manage their studying independently, yet evidence suggests that time is not well spent without guidance. Social-cognitivist models of self-regulated learning suggest value when guiding learners to set goals related to their performance processes (actions producing outcomes) versus their performance outcomes (products of performance).

Hypotheses: We expected participants oriented to set process goals would demonstrate better suturing skill retention compared with participants oriented to set outcome goals. Read More

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http://dx.doi.org/10.1080/10401334.2019.1600520DOI Listing
April 2019
1 Read

Evaluating measures of association for single-cell transcriptomics.

Nat Methods 2019 Apr 8. Epub 2019 Apr 8.

Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.

Single-cell transcriptomics provides an opportunity to characterize cell-type-specific transcriptional networks, intercellular signaling pathways and cellular diversity with unprecedented resolution by profiling thousands of cells in a single experiment. However, owing to the unique statistical properties of scRNA-seq data, the optimal measures of association for identifying gene-gene and cell-cell relationships from single-cell transcriptomics remain unclear. Here, we conducted a large-scale evaluation of 17 measures of association for their ability to reconstruct cellular networks, cluster cells of the same type and link cell-type-specific transcriptional programs to disease. Read More

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http://dx.doi.org/10.1038/s41592-019-0372-4DOI Listing

"You can't chain a dog to a porch": a multisite qualitative analysis of youth narratives of parental approaches to substance use.

Harm Reduct J 2019 Apr 5;16(1):26. Epub 2019 Apr 5.

School of Nursing, University of British Columbia, T201-2211 Westbrook Mall, Vancouver, BC, V6T 2B5, Canada.

Background: Reducing harms of youth substance use is a global priority, with parents identified as a key target for efforts to mitigate these harms. Much of the research informing parental responses to youth substance use are grounded in abstinence and critiqued as ineffective and unresponsive to youth contexts. Parental provision of substances, particularly alcohol, is a widely used approach, which some parents adopt in an attempt to minimize substance use harms; however, research indicates that this practice may actually increase harms. Read More

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http://dx.doi.org/10.1186/s12954-019-0297-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451235PMC

The Responsibility to Recontact Research Participants after Reinterpretation of Genetic and Genomic Research Results.

Am J Hum Genet 2019 Apr;104(4):578-595

Social Issues Committee, American Society of Human Genetics, Rockville, MD 20852, USA; Division of General Internal Medicine, Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.

The evidence base supporting genetic and genomic sequence-variant interpretations is continuously evolving. An inherent consequence is that a variant's clinical significance might be reinterpreted over time as new evidence emerges regarding its pathogenicity or lack thereof. This raises ethical, legal, and financial issues as to whether there is a responsibility to recontact research participants to provide updates on reinterpretations of variants after the initial analysis. Read More

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http://dx.doi.org/10.1016/j.ajhg.2019.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451731PMC
April 2019
1 Read

Weight-bearing in ankle fractures: An audit of UK practice.

Foot (Edinb) 2019 Feb 14;39:28-36. Epub 2019 Feb 14.

British Orthopaedic Network Environment - The British Orthopaedic Trainees Association, British Orthopaedic Association, London, UK.

Introduction: The purpose of this national study was to audit the weight-bearing practice of orthopaedic services in the National Health Service (NHS) in the treatment of operatively and non-operatively treated ankle fractures.

Methods: A multicentre prospective two-week audit of all adult ankle fractures was conducted between July 3rd 2017 and July 17th 2017. Fractures were classified using the AO/OTA classification. Read More

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http://dx.doi.org/10.1016/j.foot.2019.02.005DOI Listing
February 2019
2 Reads

Febrile Seizures: Risks, Evaluation, and Prognosis.

Am Fam Physician 2019 Apr;99(7):445-450

University of South Carolina Greenville School of Medicine, Greenville, SC, USA.

A febrile seizure is a seizure occurring in a child six months to five years of age that is accompanied by a fever (100.4°F or greater) without central nervous system infection. Febrile seizures are classified as simple or complex. Read More

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April 2019
2 Reads

Deep neural maps for unsupervised visualization of high-grade cancer in prostate biopsies.

Int J Comput Assist Radiol Surg 2019 Mar 23. Epub 2019 Mar 23.

Queen's University, Kingston, ON, Canada.

Prostate cancer (PCa) is the most frequent noncutaneous cancer in men. Early detection of PCa is essential for clinical decision making, and reducing metastasis and mortality rates. The current approach for PCa diagnosis is histopathologic analysis of core biopsies taken under transrectal ultrasound guidance (TRUS-guided). Read More

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http://dx.doi.org/10.1007/s11548-019-01950-0DOI Listing

Genetically informed captive breeding of hybrids of an extinct species of Galapagos tortoise.

Conserv Biol 2019 Mar 22. Epub 2019 Mar 22.

Department of Ecology and Evolutionary Biology, New Haven, Connecticut, 06520, USA.

Hybridization poses a major challenge for species conservation because it threatens both genetic integrity and adaptive potential. Yet, hybridization can occasionally offer unprecedented opportunity for species recovery if the genome of an extinct taxon is present among living hybrids such that selective breeding could re-capture it. In this paper we explore the design elements for establishing a captive breeding program for Galapagos tortoises built around individuals with admixed ancestry involving an extinct species. Read More

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http://dx.doi.org/10.1111/cobi.13319DOI Listing

'': a cross-sectional study within the UK investigating experiences of female Muslim medical health professionals on bare below the elbows (BBE) policy and wearing headscarves (hijabs) in theatre.

BMJ Open 2019 Mar 20;9(3):e019954. Epub 2019 Mar 20.

School of Health Sciences, University of Nottingham, Nottingham, UK.

Objectives: The objective of this study is to explore the impact of workplace dress code policies and guidance that may influence inclusivity and opportunities in the workplace.

Design: Quantitative, self-completion cross-sectional survey.

Setting: British Islamic Medical Association conference. Read More

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http://dx.doi.org/10.1136/bmjopen-2017-019954DOI Listing

Maternal unwanted and intrusive thoughts of infant-related harm, obsessive-compulsive disorder and depression in the perinatal period: study protocol.

BMC Psychiatry 2019 Mar 21;19(1):94. Epub 2019 Mar 21.

Department of Psychiatry, University of British Columbia, Vancouver, Canada.

Background: Unwanted, intrusive thoughts of harm-related to the infant are reported by the vast majority of new mothers, with half of all new mothers reporting unwanted, intrusive thoughts of harming their infant on purpose. Thoughts of intentional harm, in particular, are distressing to women, their partners and the people who care for them. While maternal, unwanted and intrusive thoughts of infant-related harm are known to be associated with obsessive compulsive disorder (OCD) and depression, preliminary evidence suggests that they are not associated with an increased risk of harm to infants. Read More

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http://dx.doi.org/10.1186/s12888-019-2067-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429780PMC
March 2019
4 Reads

Toxicologic Pathology Forum: Opinion on Sexual Maturity and Fertility Assessment in Long-tailed Macaques ( Macaca fascicularis) in Nonclinical Safety Studies.

Toxicol Pathol 2019 Mar 21:192623319831009. Epub 2019 Mar 21.

1 Covance Preclinical Services GmbH, Münster, Germany.

If nonhuman primates represent the only relevant species for nonclinical safety evaluation of biotechnology-derived products, male and female fertility effects can be assessed in repeat dose toxicity studies given that sexually mature monkeys are used. This opinion piece provides recommendations for determining sexual maturity and when/how fertility assessments should be conducted in the cynomolgus monkey. Male sexual maturity should be proven by presence of sperm in a semen sample, female sexual maturity by at least two consecutive menstrual bleedings. Read More

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http://dx.doi.org/10.1177/0192623319831009DOI Listing
March 2019
1 Read

Experiences of in-patient mental health services: systematic review.

Br J Psychiatry 2019 Mar 21:1-10. Epub 2019 Mar 21.

Professor of Mental Health,Division of Health Sciences,Warwick Medical School,University of Warwick;and School of Health and Related Research (ScHARR),University of Sheffield,UK.

Background: In-patients in crisis report poor experiences of mental healthcare not conducive to recovery. Concerns include coercion by staff, fear of assault from other patients, lack of therapeutic opportunities and limited support. There is little high-quality evidence on what is important to patients to inform recovery-focused care. Read More

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http://dx.doi.org/10.1192/bjp.2019.22DOI Listing
March 2019
1 Read

Building the framework for standardized clinical laboratory reporting of next generation sequencing data for resistance-associated mutations in Mycobacterium tuberculosis complex.

Clin Infect Dis 2019 Mar 18. Epub 2019 Mar 18.

Critical Path Institute, Tucson, Arizona, USA.

Tuberculosis is the primary infectious disease killer worldwide, with a growing threat from multidrug- resistant cases. Unfortunately, classic growth-based phenotypic drug susceptibility testing (DST) remains difficult, costly and time-consuming, while current rapid molecular testing options are limited by the diversity of antimicrobial resistant genotypes that can be detected at once. Next generation sequencing (NGS) offers the opportunity for rapid, comprehensive DST without the time or cost burden of phenotypic tests and can provide useful information for global surveillance. Read More

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http://dx.doi.org/10.1093/cid/ciz219DOI Listing
March 2019
8.886 Impact Factor

On the feasibility of transperineal 3D ultrasound image guidance for robotic radical prostatectomy.

Int J Comput Assist Radiol Surg 2019 Mar 13. Epub 2019 Mar 13.

Department of Electrical and Computer Engineering, University of British Columbia, 2332 Main Mall, Vancouver, BC, V6T 1Z4, Canada.

Purpose: Prostate cancer is the most prevalent form of male-specific cancers. Robot-assisted laparoscopic radical prostatectomy (RALRP) using the da Vinci surgical robot has become the gold-standard treatment for organ-confined prostate cancer. To improve intraoperative visualization of anatomical structures, many groups have developed techniques integrating transrectal ultrasound (TRUS) into the surgical workflow. Read More

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http://link.springer.com/10.1007/s11548-019-01938-w
Publisher Site
http://dx.doi.org/10.1007/s11548-019-01938-wDOI Listing
March 2019
5 Reads

Autonomic Dysreflexia in Patients With Spinal Cord Injury: What the Radiologist Needs to Know.

AJR Am J Roentgenol 2019 Mar 12:1-5. Epub 2019 Mar 12.

1 Department of Radiology, University of British Columbia, Vancouver General Hospital, 899 W 12th Ave, Vancouver, BC V5Z 1M9, Canada.

Objective: Autonomic dysreflexia (AD) is a potentially life-threatening condition that occurs in patients with cervical and high thoracic spinal cord injury (SCI). AD is not completely understood and has a high incidence that increases proportional to the level and severity of the SCI. The signs and symptoms can vary, but severe hypertension is a dominant feature and may be fatal. Read More

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https://www.ajronline.org/doi/10.2214/AJR.18.20798
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http://dx.doi.org/10.2214/AJR.18.20798DOI Listing
March 2019
3 Reads

Clinical Practice Guideline for the Management of Luminal Crohn's Disease: The Toronto Consensus.

Clin Gastroenterol Hepatol 2019 Mar 7. Epub 2019 Mar 7.

Section of Gastroenterology, University of Manitoba, Winnipeg, Manitoba.

Background & Aims: Crohn's disease (CD) is a lifelong illness with substantial morbidity, although new therapies and treatment paradigms have been developed. We provide guidance for treatment of ambulatory patients with mild to severe active luminal CD.

Methods: We performed a systematic review to identify published studies of the management of CD. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.02.043DOI Listing
March 2019
1 Read

Visuomotor adaptation in the absence of input from early visual cortex.

Cortex 2019 Feb 7;115:201-215. Epub 2019 Feb 7.

Department of Psychology, University of British Columbia, Vancouver, British Columbia, Canada.

Prism adaptation is a time-honored tool for studying how the motor system adapts to sensory perturbations. Past research on the neural substrates of prism adaptation has implicated the posterior parietal cortex (PPC) and the cerebellum, under the assumption that these structures gain their visual input from the dominant retinogeniculate pathway to V1. Here we question whether this pathway is even required for visuomotor adaptation to occur. Read More

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http://dx.doi.org/10.1016/j.cortex.2019.01.022DOI Listing
February 2019

Imaging-Guided Superior Ophthalmic Vein Access for Embolization of Dural Carotid Cavernous Fistulas: Report of 20 Cases and Review of the Literature.

AJNR Am J Neuroradiol 2019 Apr 7;40(4):699-702. Epub 2019 Mar 7.

From the Department of Radiology (M.K.S.H., D.V., J.R.S.), University of British Columbia, Vancouver, British Columbia, Canada.

Dural carotid cavernous fistulas are usually treated via a transvenous approach through the inferior petrosal sinus. Surgical exposure and direct access to the superior ophthalmic vein have been previously described in situations in which conventional transvenous access, including the inferior petrosal sinus, is not possible. In this retrospective study of 20 patients, we report our results of imaging-guided percutaneous superior ophthalmic vein access in dural carotid cavernous fistula treatment. Read More

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http://dx.doi.org/10.3174/ajnr.A5994DOI Listing

Guidelines for the Management of Pediatric Severe Traumatic Brain Injury, Third Edition: Update of the Brain Trauma Foundation Guidelines, Executive Summary.

Pediatr Crit Care Med 2019 Mar;20(3):280-289

Herman and Faye Sarkowsky Endowed Chair, Head, Division of Pediatric Neurology, University of Washington, Seattle Children's Hospital, Seattle, WA.

Objectives: The purpose of this work is to identify and synthesize research produced since the second edition of these Guidelines was published and incorporate new results into revised evidence-based recommendations for the treatment of severe traumatic brain injury in pediatric patients.

Methods And Main Results: This document provides an overview of our process, lists the new research added, and includes the revised recommendations. Recommendations are only provided when there is supporting evidence. Read More

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http://dx.doi.org/10.1097/PCC.0000000000001736DOI Listing
March 2019
31 Reads

Healthy Eating and Active Lifestyles for Diabetes (HEAL-D): study protocol for the design and feasibility trial, with process evaluation, of a culturally tailored diabetes self-management programme for African-Caribbean communities.

BMJ Open 2019 Mar 1;9(2):e023733. Epub 2019 Mar 1.

Diabetes & Nutritional Sciences Division, King's College London, London, UK.

Introduction: Black British communities are disproportionately burdened by type 2 diabetes (T2D) and its complications. Tackling these inequalities is a priority for healthcare providers and patients. Culturally tailored diabetes education provides long-term benefits superior to standard care, but to date, such programmes have only been developed in the USA. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023733DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398623PMC
March 2019
1 Read

Guidelines for the Management of Pediatric Severe Traumatic Brain Injury, Third Edition: Update of the Brain Trauma Foundation Guidelines, Executive Summary.

Neurosurgery 2019 Mar 2. Epub 2019 Mar 2.

Division of Pediatric Neurology, University of Washington, Seattle Children's Hospital, Seattle, Washington.

The purpose of this work is to identify and synthesize research produced since the second edition of these Guidelines was published and incorporate new results into revised evidence-based recommendations for the treatment of severe traumatic brain injury in pediatric patients. This document provides an overview of our process, lists the new research added, and includes the revised recommendations. Recommendations are only provided when there is supporting evidence. Read More

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http://dx.doi.org/10.1093/neuros/nyz051DOI Listing
March 2019
7 Reads

Outcomes indicators and processes in transitional care in adolescents with haemophilia: A Delphi survey of Canadian haemophilia care providers.

Haemophilia 2019 Mar 28;25(2):296-305. Epub 2019 Feb 28.

Division of Hematology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Introduction: It is unclear which outcome indicators should be used to measure the success of haemophilia transition programs, and what are key elements of a haemophilia transition program to ensure success.

Aim: To establish by expert consensus a list of important and feasible outcome indicators of successful haemophilia transition, and a list of key elements of transition planning.

Methods: A modified two-stage Delphi survey was developed and disseminated among a panel of Canadian interdisciplinary haemophilia care providers. Read More

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http://dx.doi.org/10.1111/hae.13699DOI Listing
March 2019
3 Reads

Vocational experiences and career support opportunities among Canadian men with moderate and severe haemophilia.

Haemophilia 2019 Feb 28. Epub 2019 Feb 28.

Division of Hematology, Department of Medicine, St. Paul's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.

Aim: The purpose of this research was to provide haemophilia treatment centres (HTCs) with guidance for the potential development of appropriate and timely interventions related to employment and vocational counselling and supports.

Methods: A multi-method approach was employed, where initial focus groups (n = 13) and review of the literature were used to construct a structured survey instrument (n = 75).

Results: Focus group participants made choices about employment with keen awareness of how their bleeding disorder might limit them physically; they described the role of social networks in career choices; and they wrestled with issues of disclosure. Read More

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http://dx.doi.org/10.1111/hae.13701DOI Listing
February 2019
1 Read

Radioembolization of Hepatocellular Carcinoma with Built-In Dosimetry: First Results with Uniformly-Sized, Biodegradable Microspheres Labeled with Re.

Theranostics 2019 25;9(3):868-883. Epub 2019 Jan 25.

Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC Canada.

A common form of treatment for patients with hepatocellular carcinoma (HCC) is transarterial radioembolization (TARE) with non-degradable glass or resin microspheres (MS) labeled with Y (Y-MS). To further simplify the dosimetry calculations in the clinical setting, to have more control over the particle size and to change the permanent embolization to a temporary one, we developed uniformly-sized, biodegradable Re-labeled MS (Re-MS) as a new and easily imageable TARE agent. MS made of poly(-lactic acid) were produced in a flow focusing microchip. Read More

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http://dx.doi.org/10.7150/thno.29381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376476PMC
January 2019
3 Reads
7.827 Impact Factor

Visuo-Haptic-Based Multimodal Feedback Virtual Reality Solution to Improve Anxiety Symptoms: A Proof-of-Concept Study.

Psychiatry Investig 2019 Feb 21;16(2):167-171. Epub 2019 Feb 21.

Department of Psychiatry, College of Medicine, Korea University, Seoul, Republic of Korea.

With proper guidance, virtual reality (VR) can provide psychiatric therapeutic strategies within a simulated environment. The visuo-haptic-based multimodal feedback VR solution has been developed to improve anxiety symptoms through immersive experience and feedback. A proof-of-concept study was performed to investigate this VR solution. Read More

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http://dx.doi.org/10.30773/pi.2018.12.25.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393753PMC
February 2019
3 Reads

The development and theoretical application of an implementation framework for dialectical behaviour therapy: a critical literature review.

Borderline Personal Disord Emot Dysregul 2019 12;6. Epub 2019 Feb 12.

3Research Department of Clinical, Education and Health Psychology, University College London, Gower Street, London, WC1E 6BT UK.

Background: Dialectical behaviour therapy (DBT) is a third wave behaviour therapy combining behaviour based components with elements of mindfulness. Although DBT effectiveness has been explored, relatively little attention has been given to its implementation. Frameworks are often the basis for gathering information about implementation and can also direct how the implementation of an intervention is conducted. Read More

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http://dx.doi.org/10.1186/s40479-019-0102-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373034PMC
February 2019
1 Read

Update on the contraceptive contraindications.

Authors:
D Serfaty

J Gynecol Obstet Hum Reprod 2019 Feb 20. Epub 2019 Feb 20.

Hôpital St Louis, 75010, Paris, France. Electronic address:

Background: The choice of contraceptive methods has considerably increased over recent years. However, all available methods are not appropriate for all women, especially those with medical conditions or individual characteristics in whom any pregnancy, particularly unintended pregnancy, is at higher risk. The safety of contraception is crucial for these women and evidence-based guidance to help healthcare providers choosing a suitable method has been published. Read More

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http://dx.doi.org/10.1016/j.jogoh.2019.02.006DOI Listing
February 2019
1 Read

The New/Novel Oral Anticoagulants and Their Impact on Patients Being Considered for Shockwave Lithotripsy: The Findings of an International Survey of the Endourological Society.

J Endourol 2019 Apr 21;33(4):319-324. Epub 2019 Mar 21.

4 Division of Urology, Department of Surgery, Western University, London, Canada.

Introduction: Although general guidelines exist directing the management of new/novel oral anticoagulants (NOACs) in the perioperative period for open/endoscopic procedures, no consensus exists for those patients being considered for shockwave lithotripsy (SWL). To gauge current practice, we administered a survey to the international endourologic community.

Methods: A web-based survey was sent to current Endourological Society members. Read More

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http://dx.doi.org/10.1089/end.2019.0057DOI Listing

Management practice-related and modifiable factors associated with paediatric emergency return visits.

Paediatr Child Health 2019 Feb 7;24(1):e1-e7. Epub 2018 Apr 7.

Department of    Pediatrics, BC Children's Hospital Research Institute, University of   British Columbia, Vancouver, British Columbia.

Objectives: We explored practice-related factors associated with preventable unscheduled return visits to an emergency department (RTED).

Methods: We conducted a retrospective cohort study, using standardized review of health records. We included all visits with at least one RTED within 7 days of the index visit. Read More

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http://dx.doi.org/10.1093/pch/pxy039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376311PMC
February 2019

Multiple Pathways Act Together To Establish Asymmetry of the Ventral Nerve Cord in .

Genetics 2019 04 21;211(4):1331-1343. Epub 2019 Feb 21.

Department of Biological Sciences, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada

The central nervous system of most animals is bilaterally symmetrical. Closer observation often reveals some functional or anatomical left-right asymmetries. In the nematode , the most obvious asymmetry in the nervous system is found in the ventral nerve cord (VNC), where most axons are in the right axon tract. Read More

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http://dx.doi.org/10.1534/genetics.119.301999DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456319PMC

Modifying a Paediatric Rational Prescribing Tool (POPI) for Use in the UK.

Healthcare (Basel) 2019 Feb 20;7(1). Epub 2019 Feb 20.

Division of Medical Sciences & Graduate Entry Medicine, University of Nottingham, Royal Derby Hospital Centre, Uttoxeter Road, Derby, DE22 3DT, UK.

Rational prescribing tools can be used by individual prescribers, organisations, and researchers to evaluate the quality of prescribing for research and quality improvement purposes. A literature search showed that there is only one tool for evaluating rational prescribing for paediatric patients in hospital and outpatient settings. The Pediatrics: Omission of Prescriptions and Inappropriate Prescriptions (POPI) tool was developed in France and comprises 105 criteria. Read More

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http://dx.doi.org/10.3390/healthcare7010033DOI Listing
February 2019

Co-building a patient-oriented research curriculum in Canada.

Res Involv Engagem 2019 11;5. Epub 2019 Feb 11.

6Centre for Pedagogy Applied to the Health Sciences, Department of Family Medicine and Emergency Medicine, Faculty of Medicine, Université de Montréal, Montreal, QC Canada.

Plain English Summary: is a course designed and piloted in Canada to help patients, researchers, health care professionals and health system decision-makers gain an introductory understanding of patient-oriented research, the research enterprise, and how to work in a team. The course curriculum was co-developed by a diverse group of people with different lived experiences and relevant expertise. The course is meant to be delivered in a 'co-learning format' with classes comprised of all the above stakeholder groups learning together. Read More

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http://dx.doi.org/10.1186/s40900-019-0141-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369555PMC
February 2019

'Just because I'm old it doesn't mean I have to be fat': a qualitative study exploring older adults' views and experiences of weight management.

BMJ Open 2019 Feb 19;9(2):e025680. Epub 2019 Feb 19.

Department of Behavioural Science and Health, University College London, London, UK.

Objectives: The aim of this study was to explore older adults' beliefs about the appropriateness of weight management, and how their experiences and expectations of weight management have changed as they have got older.

Design: Qualitative semistructured interview study.

Setting: UK. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377572PMC
February 2019

British Menopause Society consensus statement on the management of estrogen deficiency symptoms, arthralgia and menopause diagnosis in women treated for early breast cancer.

Post Reprod Health 2019 Mar 18;25(1):21-32. Epub 2019 Feb 18.

2 Guy's and St Thomas' Hospital, London, UK.

This guidance document by the British Menopause Society provides an overview of the management of women experiencing estrogen deficiency symptoms and arthralgia following a breast cancer diagnosis. It is now recommended that breast cancer patients are referred to health care professionals with an expertise in menopause for the management of such symptoms, which in turn often involves liaison with patients' breast cancer teams. However, as many women initially present to primary health care professionals for advice, this statement is aimed to support the latter in such consultations by providing information about symptom aetiology, current management strategies and controversies and identifying useful practice points. Read More

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http://dx.doi.org/10.1177/2053369118824920DOI Listing
March 2019
1 Read

Intratympanic Steroid Use for Sudden Sensorineural Hearing Loss: Current Otolaryngology Practice.

Ann Otol Rhinol Laryngol 2019 Feb 15:3489419828759. Epub 2019 Feb 15.

1 Royal National Throat, Nose and Ear Hospital, University College London Hospitals NHS Trust, London, UK.

Objective:: To investigate the current practice of intratympanic steroid (ITS) injection for sudden sensorineural hearing loss (SSNHL) in the United Kingdom and link the data with data from the United States and continental Europe.

Methods:: A survey of 21 questions was distributed to members of the British Society of Otology using an online survey platform via ENT UK. Data obtained from UK otolaryngologists (n = 171) were integrated with previously published data from other countries, including the United States (n = 63) and continental Europe (n = 908). Read More

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http://dx.doi.org/10.1177/0003489419828759DOI Listing
February 2019
1 Read

Indications for echocardiography of replacement heart valves: a joint statement from the British Heart Valve Society and British Society of Echocardiography.

Echo Res Pract 2019 Mar;6(1):G9-G15

University of Birmingham Hospitals, Birmingham, UK.

Echocardiography plays a vital role in the follow-up of patients with replacement heart valves. However, there is considerable variation in international guidelines regarding the recommended time points after implantation at which routine echocardiography should be performed. The purpose of routine echocardiography is to detect early structural valve deterioration in biological valves to improve the timing of redo interventions. Read More

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http://dx.doi.org/10.1530/ERP-18-0079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6410760PMC
March 2019
1 Read

Objective and biological markers in bipolar spectrum presentations.

Expert Rev Neurother 2019 Mar 27;19(3):195-209. Epub 2019 Feb 27.

a Department of Psychiatry , University of British Columbia , Vancouver , BC , Canada.

Introduction: Subthreshold presentations of bipolarity (BSPs) pose a diagnostic conundrum, in terms of whether they should be conceptualized and treated similarly as traditionally defined bipolar disorders (BD). While it has been argued that BSPs are on a pathophysiologic continuum with traditionally defined BDs, there has been limited examination of biological and objective markers in these presentations to validate this assertion. Areas covered: The authors review studies examining genetic, neurobiological, cognitive and peripheral markers in BSPs, encompassing clinical and non-clinical populations with subthreshold hypo/manic symptoms. Read More

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http://dx.doi.org/10.1080/14737175.2019.1580145DOI Listing
March 2019
3 Reads

COMPare: a prospective cohort study correcting and monitoring 58 misreported trials in real time.

Trials 2019 Feb 14;20(1):118. Epub 2019 Feb 14.

Centre for Evidence-Based Medicine, Department of Primary Care Health Sciences, University of Oxford, Radcliffe Observatory Quarter, Woodstock Road, Oxford, OX2 6GG, UK.

Background: Discrepancies between pre-specified and reported outcomes are an important source of bias in trials. Despite legislation, guidelines and public commitments on correct reporting from journals, outcome misreporting continues to be prevalent. We aimed to document the extent of misreporting, establish whether it was possible to publish correction letters on all misreported trials as they were published, and monitor responses from editors and trialists to understand why outcome misreporting persists despite public commitments to address it. Read More

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http://dx.doi.org/10.1186/s13063-019-3173-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375128PMC
February 2019
1 Read

Treating to Target(s) With Interleukin-17 Inhibitors.

J Cutan Med Surg 2019 Mar/Apr;23(2_suppl):3S-34S. Epub 2019 Feb 11.

12 University of Alberta, Edmonton, AB, Canada.

Background:: The treat-to-target (T2T) strategy has become established in several medical specialties as a key guidance to optimal therapeutic decision making. T2T may be effective in the assessment of the biologic class of agents called interleukin (IL)-17 inhibitors, which are emerging as a safe and effective treatment option for autoimmune inflammatory conditions such as plaque psoriasis, psoriatic arthritis (PsA), and ankylosing spondylitis (AS).

Objective:: The objective of this article is to use a T2T approach for the evaluation of the effectiveness and safety of IL-17 inhibitors in the management of patients with plaque psoriasis, PsA, and AS. Read More

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http://dx.doi.org/10.1177/1203475418824565DOI Listing
February 2019
12 Reads

Does a hospital culture influence adherence to infection prevention and control and rates of healthcare associated infection? A literature review.

J Infect Prev 2019 Jan 9;20(1):5-17. Epub 2018 Nov 9.

Oxford Brookes University and University of Oxford, Oxford, UK.

Background: Over 4 million patients acquire a healthcare-associated infection (HCAI) in Europe every year, indicating possible shortcomings in hospitals converting evidence-based infection prevention and control (IPC) strategies into universal adherence. We present a literature review exploring whether insufficient adherence could be culturally based.

Aim: To find empirical evidence if and how specific traits of organisational culture improve adherence to IPC strategies utilising HCAI rates as the marker of system failures or successes. Read More

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http://dx.doi.org/10.1177/1757177418805833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346327PMC
January 2019
1 Read

Exploring mental health professionals' practice in relation to smoke-free policy within a mental health trust: a qualitative study using the COM-B model of behaviour.

BMC Psychiatry 2019 Feb 4;19(1):54. Epub 2019 Feb 4.

Department of Behavioural Science and Health, University College London, 1-19 Torrington Place, London, WC1E 6BT, UK.

Background: Smoking has played a significant role in the historical culture of mental healthcare settings. Mental health professionals (MHPs) often hold dismissive attitudes regarding the importance of smoking cessation in the context of mental healthcare. In 2007, English mental health inpatient buildings were required by law to become smoke-free, and healthcare trusts have more recently begun to implement comprehensive policies (i. Read More

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http://dx.doi.org/10.1186/s12888-019-2029-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360690PMC
February 2019
2 Reads

The Prevalence of Nonprescription Cannabinoid-Based Medicines in British Children's Hospices: Results of a National Survey.

J Palliat Med 2019 Feb 4. Epub 2019 Feb 4.

Martin House Children's Hospice, Wetherby, United Kingdom.

Background: Almost 50,000 children and young people are affected by life-limiting conditions in the United Kingdom, around a third of which use children's hospices. Anecdotal evidence suggests that cannabinoid-based medicines (CBMs), specifically cannabis oil (CO), are being used by families with increasing frequency to manage distressing symptoms. The use of most nonprescription CBMs in the United Kingdom remains illegal. Read More

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http://dx.doi.org/10.1089/jpm.2018.0522DOI Listing
February 2019

The role of human rights in implementing socially responsible seafood.

PLoS One 2019 25;14(1):e0210241. Epub 2019 Jan 25.

The Nippon Foundation Nereus Program, Vancouver, Canada.

Sustainability standards for seafood mainly address environmental performance criteria and are less concerned with the welfare of fisheries workers who produce the seafood. Yet human rights violations such as slavery and human trafficking are widespread in fisheries around the world, and underscore the need for certification bodies and other seafood supply chain actors to improve social performance, in addition to addressing environmental challenges. Calls for socially responsible seafood have referenced human rights law and policy frameworks to shape the guiding principles of socially responsible seafood and to provide the legal machinery to implement these aspirations, but practical guidance on how to achieve this is lacking. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210241PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347265PMC
January 2019
1 Read

Discovery of Distinct Immune Phenotypes Using Machine Learning in Pulmonary Arterial Hypertension.

Circ Res 2019 Mar;124(6):904-919

From the Division of Pulmonary and Critical Care Medicine (A.J.S., M.R.N., R.T.Z.), in the Department of Medicine, Stanford University, CA.

Rationale: Accumulating evidence implicates inflammation in pulmonary arterial hypertension (PAH) and therapies targeting immunity are under investigation, although it remains unknown if distinct immune phenotypes exist.

Objective: Identify PAH immune phenotypes based on unsupervised analysis of blood proteomic profiles.

Methods And Results: In a prospective observational study of group 1 PAH patients evaluated at Stanford University (discovery cohort; n=281) and University of Sheffield (validation cohort; n=104) between 2008 and 2014, we measured a circulating proteomic panel of 48 cytokines, chemokines, and factors using multiplex immunoassay. Read More

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https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.31391
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http://dx.doi.org/10.1161/CIRCRESAHA.118.313911DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428071PMC
March 2019
5 Reads

Improving reporting of meta-ethnography: The eMERGe reporting guidance.

Psychooncology 2019 Mar 15;28(3):447-458. Epub 2019 Jan 15.

Bangor University, Bangor, UK.

Aims: The aim of this study was to provide guidance to improve the completeness and clarity of meta-ethnography reporting.

Background: Evidence-based policy and practice require robust evidence syntheses which can further understanding of people's experiences and associated social processes. Meta-ethnography is a rigorous seven-phase qualitative evidence synthesis methodology, developed by Noblit and Hare. Read More

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http://dx.doi.org/10.1002/pon.4915DOI Listing
March 2019
5 Reads
2.443 Impact Factor

Improving reporting of meta-ethnography: The eMERGe reporting guidance.

J Adv Nurs 2019 May 15;75(5):1126-1139. Epub 2019 Jan 15.

Bangor University, Bangor, UK.

Aims: The aim of this study was to provide guidance to improve the completeness and clarity of meta-ethnography reporting.

Background: Evidence-based policy and practice require robust evidence syntheses which can further understanding of people's experiences and associated social processes. Meta-ethnography is a rigorous seven-phase qualitative evidence synthesis methodology, developed by Noblit and Hare. Read More

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http://dx.doi.org/10.1111/jan.13809DOI Listing
May 2019
3 Reads
1.685 Impact Factor

Seroma Visualization and Implant Accuracy in Permanent Breast Seed Implant Brachytherapy.

Pract Radiat Oncol 2019 Jan 11. Epub 2019 Jan 11.

Department of Radiation Oncology, BC Cancer - Southern Interior, Kelowna, British Columbia, Canada.

Purpose: This study aimed to evaluate the relationship between seroma visualization and seed placement accuracy in permanent breast seed implant brachytherapy (PBSI).

Methods And Materials: At the time of planning computed tomography (CT), 10 patients receiving PBSI were imaged with spatially co-registered 3-dimensional ultrasound (US). Seromas were independently contoured by 3 radiation oncologists on CT and US scans. Read More

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http://dx.doi.org/10.1016/j.prro.2019.01.003DOI Listing
January 2019
1 Read

Periodontal diagnosis in the context of the 2017 classification system of periodontal diseases and conditions - implementation in clinical practice.

Br Dent J 2019 01;226(1):16-22

Department of Periodontology, The School of Dentistry, University of Birmingham, Birmingham, UK.

The 2017 World Workshop Classification system for periodontal and peri-implant diseases and conditions was developed in order to accommodate advances in knowledge derived from both biological and clinical research, that have emerged since the 1999 International Classification of Periodontal Diseases. Importantly, it defines clinical health for the first time, and distinguishes an intact and a reduced periodontium throughout. The term 'aggressive periodontitis' was removed, creating a staging and grading system for periodontitis that is based primarily upon attachment and bone loss and classifies the disease into four stages based on severity (I, II, III or IV) and three grades based on disease susceptibility (A, B or C). Read More

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http://www.nature.com/doifinder/10.1038/sj.bdj.2019.3
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http://dx.doi.org/10.1038/sj.bdj.2019.3DOI Listing
January 2019
45 Reads

National consensus recommendations on patient-centered care for ductal carcinoma in situ.

Breast Cancer Res Treat 2019 Apr 9;174(3):561-570. Epub 2019 Jan 9.

Department of Surgery, University of British Columbia, Vancouver, Canada.

Purpose: The purpose of this research was to generate recommendations on strategies to achieve patient-centered care (PCC) for ductal carcinoma in situ (DCIS).

Methods: Thirty clinicians (surgeons, medical/radiation oncologists, radiologists, nurses, navigators) who manage DCIS and 32 DCIS survivors aged 18 or older were nominated. Forty-six recommendations to support PCC for DCIS were derived from primary research, and rated in a two-round Delphi process from March to June 2018. Read More

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http://dx.doi.org/10.1007/s10549-019-05132-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438938PMC
April 2019
2 Reads

Evaluation of Prescription Adaptation Following Changes to A Provincial Drug Insurance Formulary.

Authors:
Robert T Pammett

Pharmacy (Basel) 2019 Jan 7;7(1). Epub 2019 Jan 7.

Northern Health Authority, Prince George, BC V2L 5B8, Canada.

On 1 December 2016, British Columbia's (BC) provincial drug insurance program changed which medications in certain classes would benefit under the insurance program in an attempt to reduce expenditure. As part of the modernization, HMG-CoA reductase inhibitors (Statins), Angiotensin converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB), and dihydropyridine calcium channel blockers (CCB) were affected. Prescribers and pharmacists had six months to discuss the changes with patients, and change medications if deemed necessary. Read More

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http://dx.doi.org/10.3390/pharmacy7010006DOI Listing
January 2019