162,780 results match your criteria British Journal Of Educational Studies[Journal]


Repeatability of Radiomic Features in Magnetic Resonance Imaging of Glioblastoma: Test-Retest and Image Registration Analyses.

Med Phys 2020 Jul 2. Epub 2020 Jul 2.

Departments of Radiology and Physics, University of British Columbia, Vancouver, BC, Canada.

Purpose: To assess repeatability of radiomic features in magnetic resonance (MR) imaging of glioblastoma (GBM) tumors with respect to test-retest, different image registration approaches and inhomogeneity bias field correction.

Methods: We analyzed MR images of 17 GBM patients including T1 and T2-weighted images (performed within the same imaging unit on two consecutive days). For image segmentation, we used a comprehensive segmentation approach including entire tumor, active area of tumor, necrotic regions in T1-weighted images, and edema regions in T2-weighted images (test studies only; registration to retest studies is discussed next). Read More

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http://dx.doi.org/10.1002/mp.14368DOI Listing

Reimagining learning outcomes to teach laboratory courses without a lab.

Authors:
Scott D Covey

Biochem Mol Biol Educ 2020 Jul 2. Epub 2020 Jul 2.

Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1002/bmb.21404DOI Listing

Position Paper of the German Society for Interventional Radiology (DeGIR) on Prostatic Artery Embolization.

Rofo 2020 Jul 2. Epub 2020 Jul 2.

Hannover Medical School, Department of Diagnostic and Interventional Radiology, Hannover, Germany.

Background:  In recent years prostate artery embolization (PAE) evolved into a clinically established minimally invasive endovascular treatment option for lower urinary tract symptoms caused by benign prostate syndrome (BPS).

Methods:  In this interdisciplinary position paper, initiated by the steering group for research of the German Society for Interventional Radiology (IR), the method of PAE is presented and discussed in the context of current evidence.

Results:  PAE is a safe IR procedure for the treatment of BPS. Read More

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http://dx.doi.org/10.1055/a-1183-5438DOI Listing

Beyond implantation effect? Long-term seizure reduction and freedom following intracranial monitoring without additional surgical interventions.

Epilepsy Behav 2020 Jun 29;111:107231. Epub 2020 Jun 29.

Comprehensive Epilepsy Center, Department of Neurology, Yale University, New Haven, CT, United States of America. Electronic address:

The term 'implantation effect' is used to describe an immediate and transient improvement in seizure frequency following an intracranial study for seizure onset localization. We conducted a retrospective analysis of 190 consecutive patients undergoing intracranial electroencephalogram (EEG) monitoring, of whom 41 had no subsequent resection/ablation/stimulation; 33 had adequate data and follow-up time available for analysis. Analysis of seizure frequency following an intracranial study showed 36% (12/33) responder rate (>50% seizure reduction) at one year, decreasing and stabilizing at 20% from year 4 onwards. Read More

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http://dx.doi.org/10.1016/j.yebeh.2020.107231DOI Listing

Alternating dual-task inference between visual words and faces.

Brain Res 2020 Jun 29:147004. Epub 2020 Jun 29.

Human Vision and Eye Movement Laboratory, Departments of Medicine (Neurology), Ophthalmology and Visual Sciences, Psychology, University of British Columbia, Vancouver, Canada. Electronic address:

The recent many-to-many hypothesis proposes that face and visual word recognition share and even compete for high-level perceptual resources in both hemispheres. However, it is still not clear whether the processing performed by the two hemispheres on faces and visual words is equivalent or complementary. We performed an alternating dual-task experiment to determine if the processing of visual words and faces interfered with each other, and if such interference depended upon the stimulus attribute being processed. Read More

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http://dx.doi.org/10.1016/j.brainres.2020.147004DOI Listing

Expert Opinion on the Management and Follow-up of Uveitis Patients during SARS-CoV-2 Outbreak.

Expert Rev Clin Immunol 2020 Jul 2. Epub 2020 Jul 2.

Department of Ophthalmology, IHU FOReSIGHT, Sorbonne University-APHP , Paris, France.

Introduction: Routine medical and ophthalmic care is being drastically curtailed in the context of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Uveitis patients require particular attention because of their theoretical risk of viral infection, in the context of therapeutic immunosuppression.

Areas Covered: This collaborative work proposes practical management and follow-up criteria for uveitis patients in the context of the ongoing SARS-CoV-2 pandemic. Read More

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http://dx.doi.org/10.1080/1744666X.2020.1791086DOI Listing
July 2020
3.342 Impact Factor

Resolution-Associated Molecular Patterns (RAMPs) as Endogenous Regulators of Glia Functions in Neuroinflammatory Disease.

CNS Neurol Disord Drug Targets 2020 Jul 2. Epub 2020 Jul 2.

Department of Biology, University of British Columbia Okanagan Campus, Kelowna, British Columbia, V1V 1V7. Canada.

Glial cells, including microglia and astrocytes, facilitate the survival and health of all cells within the central nervous system (CNS) by secreting a range of growth factors and contributing to tissue and synaptic remodeling. Microglia and astrocytes can also secrete cytotoxins in response to specific stimuli, such as exogenous pathogen-associated molecular patterns (PAMPs), or endogenous damage-associated molecular patterns (DAMPs). Excessive cytotoxic secretions can induce the death of neurons and contribute to the progression of neurodegenerative disorders, such as Alzheimer's disease (AD). Read More

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http://dx.doi.org/10.2174/1871527319666200702143719DOI Listing

Histopathologic Assessment of Suspected Idiopathic Pulmonary Fibrosis: Where We Are and Where We Need to Go.

Arch Pathol Lab Med 2020 Jul 2. Epub 2020 Jul 2.

and the Department of Pathology, Mount Sinai Health System, Icahn School of Medicine, New York, New York (Dr Beasley).

Context.—: Accurate diagnosis of idiopathic pulmonary fibrosis (IPF) requires multidisciplinary diagnosis that includes clinical, radiologic, and often pathologic assessment. In 2018, the American Thoracic Society, European Respiratory Society, Japanese Respiratory Society, and the Latin American Thoracic Society (ATS/ERS/JRS/ALAT) and the Fleischner Society each published guidelines for the diagnosis of IPF, which include criteria for 4 categories of confidence of a histologic usual interstitial pneumonia (UIP) pattern. Read More

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http://dx.doi.org/10.5858/arpa.2020-0052-RADOI Listing

Using machine learning to quantify structural MRI neurodegeneration patterns of Alzheimer's disease into dementia score: Independent validation on 8,834 images from ADNI, AIBL, OASIS, and MIRIAD databases.

Hum Brain Mapp 2020 Jul 2:e25115. Epub 2020 Jul 2.

School of Engineering Science, Simon Fraser University, Barnaby, British Columbia, Canada.

Biomarkers for dementia of Alzheimer's type (DAT) are sought to facilitate accurate prediction of the disease onset, ideally predating the onset of cognitive deterioration. T1-weighted magnetic resonance imaging (MRI) is a commonly used neuroimaging modality for measuring brain structure in vivo, potentially providing information enabling the design of biomarkers for DAT. We propose a novel biomarker using structural MRI volume-based features to compute a similarity score for the individual's structural patterns relative to those observed in the DAT group. Read More

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http://dx.doi.org/10.1002/hbm.25115DOI Listing

Matrix metalloproteinase 15 plays a pivotal role in human first trimester cytotrophoblast invasion and is not altered by maternal obesity.

FASEB J 2020 Jul 2. Epub 2020 Jul 2.

Department of Obstetrics and Gynecology, Medical University of Graz, Graz, Austria.

Adequate anchoring of the placenta in the uterus through invasion of first trimester cytotrophoblasts (CTB) is required for a successful pregnancy. This process is mediated by matrix metalloproteinases (MMPs) and regulated by the maternal environment. Obesity is known to alter the intrauterine milieu and has been related to impaired invasion. Read More

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http://dx.doi.org/10.1096/fj.202000773RDOI Listing

Association of Atrial Fibrillation Episode Duration With Arrhythmia Recurrence Following Ablation: A Secondary Analysis of a Randomized Clinical Trial.

JAMA Netw Open 2020 Jul 1;3(7):e208748. Epub 2020 Jul 1.

Montreal Heart Institute, Department of Medicine, Université de Montréal, Montréal, Quebec, Canada.

Importance: Contemporary guidelines recommend that atrial fibrillation (AF) be classified based on episode duration, with these categories forming the basis of therapeutic recommendations. While pragmatic, these classifications are not based on pathophysiologic processes and may not reflect clinical outcomes.

Objective: To evaluate the association of baseline AF episode duration with post-AF ablation arrhythmia outcomes. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.8748DOI Listing

Impact of Time-To-Surgery and Surgical Delay on Oncologic Outcomes for Renal Cell Carcinoma.

J Urol 2020 Jul 2:101097JU0000000000001230. Epub 2020 Jul 2.

Section of Urology, University of Manitoba, Winnipeg, Manitoba, Canada.

Purpose: The time between radiographic identification of a renal tumor and surgery can be concerning for patients and clinicians due to fears of tumor progression while awaiting treatment. This study aimed to evaluate the association between surgical wait time and oncologic outcomes for patients with renal cell carcinoma (RCC).

Materials And Methods: The Canadian Kidney Cancer information system (CKCis) is a multi-institutional prospective cohort initiated in January 2011. Read More

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http://dx.doi.org/10.1097/JU.0000000000001230DOI Listing

Active surveillance of acute paediatric hospitalisations demonstrates the impact of vaccination programmes and informs vaccine policy in Canada and Australia.

Euro Surveill 2020 Jun;25(25)

The IMPACT and PAEDS investigators are acknowledged at the end of this article.

Sentinel surveillance of acute hospitalisations in response to infectious disease emergencies such as the 2009 influenza A(H1N1)pdm09 pandemic is well described, but recognition of its potential to supplement routine public health surveillance and provide scalability for emergency responses has been limited. We summarise the achievements of two national paediatric hospital surveillance networks relevant to vaccine programmes and emerging infectious diseases in Canada (Canadian Immunization Monitoring Program Active; IMPACT from 1991) and Australia (Paediatric Active Enhanced Disease Surveillance; PAEDS from 2007) and discuss opportunities and challenges in applying their model to other contexts. Both networks were established to enhance capacity to measure vaccine preventable disease burden, vaccine programme impact, and safety, with their scope occasionally being increased with emerging infectious diseases' surveillance. Read More

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http://dx.doi.org/10.2807/1560-7917.ES.2020.25.25.1900562DOI Listing

Novel insights into the taxonomic diversity and molecular mechanisms of bacterial Mn(III) reduction.

Environ Microbiol Rep 2020 Jul 2. Epub 2020 Jul 2.

School of Earth and Atmospheric Sciences, Georgia Institute of Technology, Atlanta, GA, USA.

Soluble ligand-bound Mn(III) can support anaerobic microbial respiration in diverse aquatic environments. Thus far, Mn(III) reduction has only been associated with certain Gammaproteobacteria. Here, we characterized microbial communities enriched from Mn-replete sediments of Lake Matano, Indonesia. Read More

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http://dx.doi.org/10.1111/1758-2229.12867DOI Listing

Vacuum microwave dehydration decreases volatile concentration and soluble protein content of pea (Pisum sativum, L.) protein.

J Sci Food Agric 2020 Jul 1. Epub 2020 Jul 1.

Food, Nutrition and Health, Faculty of Land and Food Systems, the University of British Columbia 2205 East Mall, Vancouver, BC V6T-1Z4, Canada.

Background: Peas are an inexpensive, yet nutritious and sustainable source of protein. However, it is challenging to incorporate pea proteins into food formulations due to their beany or green off-flavours and their limited water solubility.

Results: Vacuum microwave dehydration (VMD) of pea protein with an initial moisture content of 425% (dry basis) at 2W/g specific microwave energy and 200 torrs vacuum level for 88 minutes led to an 83% reduction in total volatile compound concentration. Read More

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http://dx.doi.org/10.1002/jsfa.10627DOI Listing

Modelling of multi-minerals kinetic evolution in hyper-alkaline leachate for a 15-year experiment.

Environ Sci Pollut Res Int 2020 Jun 29. Epub 2020 Jun 29.

Groundwater Protection and Restoration Group, Dept of Civil and Structural Engineering, The University of Sheffield, Sheffield, UK.

Cement has been widely used for low- to intermediate-level radioactive waste management; however, the long-term modelling of multiple mineral transfer between the cement leachate and the host rock of a geological disposal facility remains a challenge due to the strong physical-chemical interactions within the chemically disturbed zone. This paper presents a modelling study for a 15-year experiment simulating the reaction of crystalline basement rock with evolved near-field groundwater (pH = 10.8). Read More

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http://dx.doi.org/10.1007/s11356-020-09875-xDOI Listing

Facing the unknown: uncertain fertility in young adult survivors of childhood cancer.

J Cancer Surviv 2020 Jul 1. Epub 2020 Jul 1.

Department of Radiation Oncology, BC Cancer Agency, Vancouver, Canada.

Purpose: The purpose of this research was to describe the challenges young adult childhood cancer survivors (ACCS) experience of living with an unknown fertility status.

Methods: In this qualitative study, we analyzed data from in-depth interviews with 25 ACCS (15 females, 10 males) using content-driven inductive thematic analysis and constant comparative techniques.

Results: Three themes provide insight into ACCS' experiences of living with an uncertain fertility status. Read More

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http://dx.doi.org/10.1007/s11764-020-00910-xDOI Listing

Persistence and adherence to parenteral osteoporosis therapies: a systematic review.

Osteoporos Int 2020 Jul 1. Epub 2020 Jul 1.

Department of Medicine, Division of Rheumatology, University of Alberta, 8-130 Clinical Sciences Building, 11350 83rd Avenue NW, Edmonton, AB, T6G 2G3, Canada.

Osteoporosis is a chronic disease of low bone mass and fragility. Treatment is frequently compromised by suboptimal medication compliance causing increased morbidity. This review investigates adherence and persistence to parenteral osteoporosis therapies. Read More

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http://dx.doi.org/10.1007/s00198-020-05507-9DOI Listing

Training prostate cancer survivors and caregivers to be peer navigators: a blended online/in-person competency-based training program.

Support Care Cancer 2020 Jul 2. Epub 2020 Jul 2.

Division of Health Services and Policy, School of Population and Public Health, University of British Columbia, Vancouver, Canada.

Purpose: Cancer navigation improves access to support and reduces barriers to care; however, appropriate training of navigators is essential. We developed the TrueNTH Peer Navigation Training Program (PNTP), a competency-based, blended online/in-person course. In this study, we evaluate the feasibility, acceptability, and effectiveness of the PNTP among prostate cancer (PC) survivors (patients, caregivers). Read More

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http://dx.doi.org/10.1007/s00520-020-05586-8DOI Listing

Quality of same-day CT colonography following incomplete optical colonoscopy.

Eur Radiol 2020 Jul 1. Epub 2020 Jul 1.

Department of Radiology, Beaumont Hospital, Beaumont Road, Dublin 9, Ireland.

Objectives: Same-day CT colonography (CTC) following incomplete optical colonoscopy allows patients to avoid both a delayed diagnosis and the need for repeat bowel preparation. The aim of our study is to establish the diagnostic quality of same-day CT colonography following an incomplete optical colonoscopy.

Methods: We performed a retrospective review of patients undergoing same-day CT colonography following an incomplete colonoscopy at our center between July 2015 and December 2017 (N = 245). Read More

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http://dx.doi.org/10.1007/s00330-020-06979-3DOI Listing

The iCanCope pain self-management application for adolescents with juvenile idiopathic arthritis: a pilot randomized controlled trial.

Rheumatology (Oxford) 2020 Jul 2. Epub 2020 Jul 2.

Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, Ontario.

Objectives: To evaluate the feasibility and preliminary effectiveness of iCanCope with Pain (iCanCope), a smartphone-based pain self-management program, in adolescents with JIA. iCanCope featured symptom tracking, goal-setting, pain coping skills and social support.

Methods: A two-arm pilot randomized controlled trial was used to evaluate the iCanCope app compared with a version with symptom tracking only. Read More

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http://dx.doi.org/10.1093/rheumatology/keaa178DOI Listing

Estimating the number of excess deaths attributable to heat in 297 United States counties.

Environ Epidemiol 2020 Jun 23;4(3):e096. Epub 2020 Apr 23.

Department of Epidemiology, Brown University School of Public Health, Providence, Rhode Island.

There is a well-established relationship between high ambient temperature and risk of death. However, the number of deaths attributable to heat each year in the United States remains incompletely quantified.

Methods: We replicated the approach from a large, international study to estimate temperature-mortality associations in 297 United States counties and additionally calculated the number of deaths attributable to heat, a quantity of likely interest to policymakers and the public. Read More

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http://dx.doi.org/10.1097/EE9.0000000000000096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289128PMC

Black, Asian and Minority Ethnic groups in England are at increased risk of death from COVID-19: indirect standardisation of NHS mortality data.

Wellcome Open Res 2020 6;5:88. Epub 2020 May 6.

UCL Collaborative Centre for Inclusion Health, Institute of Epidemiology and Health Care, UCL, London, WC1E 7HB, UK.

: International and UK data suggest that Black, Asian and Minority Ethnic (BAME) groups are at increased risk of infection and death from COVID-19. We aimed to explore the risk of death in minority ethnic groups in England using data reported by NHS England. : We used NHS data on patients with a positive COVID-19 test who died in hospitals in England published on 28th April, with deaths by ethnicity available from 1st March 2020 up to 5pm on 21 April 2020. Read More

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http://dx.doi.org/10.12688/wellcomeopenres.15922.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317462PMC

Opioid agonist therapy trajectories among street entrenched youth in the context of a public health crisis.

SSM Popul Health 2020 Aug 4;11:100609. Epub 2020 Jun 4.

British Columbia Centre on Substance Use, Vancouver, Canada.

North America is in the midst of an overdose crisis that is having devastating effects among street entrenched youth (<30 years of age). Opioid agonist therapy (OAT) is a cornerstone of the public health response to this crisis; yet, we struggle to connect youth to OAT across numerous settings. This qualitative study examined perspectives on OAT among street entrenched youth and their providers in Vancouver, Canada. Read More

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http://dx.doi.org/10.1016/j.ssmph.2020.100609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317668PMC

A comparison of cardiovascular risk scores in native and migrant South Asian populations.

SSM Popul Health 2020 Aug 11;11:100594. Epub 2020 May 11.

Freeman Hospital, Newcastle-upon-Tyne, UK.

Background: South Asians have increased cardiovascular risk burden but little data exists comparing cardiovascular (CV) risk models in migrant and native South Asians. Our retrospective cohort study in patients presenting with first acute myocardial infarction(MI) compares the predictive value of CV risk scores in native and UK migrant South Asians.

Methods: Retrospective cohort study of 80 UK-based patients of South Asian origin admitted with first presentation MI, excluding patients with known coronary artery disease. Read More

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http://dx.doi.org/10.1016/j.ssmph.2020.100594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322355PMC

Tracheobronchomegaly, cough and recurrent chest infection: Mounier-Kuhn syndrome.

ERJ Open Res 2020 Apr 29;6(2). Epub 2020 Jun 29.

McMaster University, Dept of Medicine, Division of Respirology, Hamilton, Canada.

https://bit.ly/3azhDjr. Read More

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http://dx.doi.org/10.1183/23120541.00138-2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322912PMC

Assessing bias in demographic estimates from joint live and dead encounter models.

PeerJ 2020 23;8:e9382. Epub 2020 Jun 23.

Science and Technology Branch, Prairie and Northern Wildlife Research Centre, Environment and Climate Change Canada, Saskatoon, SK, Canada.

Joint encounter (JE) models estimate demographic rates using live recapture and dead recovery data. The extent to which limited recapture or recovery data can hinder estimation in JE models is not completely understood. Yet limited data are common in ecological research. Read More

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http://dx.doi.org/10.7717/peerj.9382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319022PMC

Detection of first gammaherpesvirus sequences in Central African bats.

New Microbes New Infect 2020 Jul 3;36:100705. Epub 2020 Jun 3.

Metabiota Inc, Nanaimo, BC, Canada.

Herpesviruses have been identified in many species; however, relatively few bat herpesvirus are known, considering the enormous diversity of bats. We used consensus PCR to test bats from the Republic of the Congo and found DNA of two different novel bat herpesviruses. One was detected in a , the other in a bat and both resemble gammaherpesviruses. Read More

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http://dx.doi.org/10.1016/j.nmni.2020.100705DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322348PMC

Amygdala Nuclei Volumes Are Selectively Associated With Social Network Size in Homeless and Precariously Housed Persons.

Front Behav Neurosci 2020 16;14:97. Epub 2020 Jun 16.

Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.

: The amygdala is a brain region comprised of a group of functionally distinct nuclei that play a central role in social behavior. In homeless and precariously housed individuals, high rates of multimorbidity, and structural aspects of the environment may dysregulate social functioning. This study examined the neurobiological substrates of social connection in homeless and precariously housed persons by examining associations between amygdala nuclei volumes and social network size. Read More

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http://dx.doi.org/10.3389/fnbeh.2020.00097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309349PMC

Comprehensive Imaging of Sensory-Evoked Activity of Entire Neurons Within the Awake Developing Brain Using Ultrafast AOD-Based Random-Access Two-Photon Microscopy.

Front Neural Circuits 2020 16;14:33. Epub 2020 Jun 16.

Department of Cellular and Physiological Sciences, Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, BC, Canada.

Determining how neurons transform synaptic input and encode information in action potential (AP) firing output is required for understanding dendritic integration, neural transforms and encoding. Limitations in the speed of imaging 3D volumes of brain encompassing complex dendritic arbors using conventional galvanometer mirror-based laser-scanning microscopy has hampered fully capturing fluorescent sensors of activity throughout an individual neuron's entire complement of synaptic inputs and somatic APs. To address this problem, we have developed a two-photon microscope that achieves high-speed scanning by employing inertia-free acousto-optic deflectors (AODs) for laser beam positioning, enabling random-access sampling of hundreds to thousands of points-of-interest restricted to a predetermined neuronal structure, avoiding wasted scanning of surrounding extracellular tissue. Read More

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http://dx.doi.org/10.3389/fncir.2020.00033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308460PMC

Boundary line models for soil nutrient concentrations and wheat yield in national-scale datasets.

Eur J Soil Sci 2020 May 15;71(3):334-351. Epub 2019 Nov 15.

British Geological Survey Nottingham UK.

In boundary line analysis a biological response (e.g., crop yield) is assumed to be a function of a variable (e. Read More

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http://dx.doi.org/10.1111/ejss.12891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318209PMC

Does contact with the justice system deter or promote future delinquency? Results from a longitudinal study of British adolescent twins.

Criminology 2020 May 29;58(2):307-335. Epub 2019 Dec 29.

Department of Psychology & Neuroscience Duke University.

What impact does formal punishment have on antisocial conduct-does it deter or promote it? The findings from a long line of research on the labeling tradition indicate formal punishments have the opposite-of-intended consequence of promoting future misbehavior. In another body of work, the results show support for deterrence-based hypotheses that punishment deters future misbehavior. So, which is it? We draw on a nationally representative sample of British adolescent twins from the Environmental Risk (E-Risk) Longitudinal Twin Study to perform a robust test of the deterrence versus labeling question. Read More

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http://dx.doi.org/10.1111/1745-9125.12236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317788PMC

Pharmacy Leadership during the COVID-19 Pandemic.

Authors:
Peter J Zed

Can J Hosp Pharm 2020 May-Jun;73(3):173-174. Epub 2020 Jun 1.

, BSc, BSc(Pharm), ACPR, PharmD, FCSHP, is Professor and Associate Dean, Practice Innovation, Faculty of Pharmaceutical Sciences, and Associate Member, Department of Emergency Medicine, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia. He is also an Associate Editor with the Canadian Journal of Hospital Pharmacy.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308150PMC

Country cardiograms case #67: Answer.

Can J Rural Med 2020 Jul-Sep;25(3):116-117

Tumbler Ridge Health Centre, British Columbia - Tumbler Ridge, Canada.

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http://dx.doi.org/10.4103/1203-7796.287692DOI Listing

Country cardiograms case #67.

Can J Rural Med 2020 Jul-Sep;25(3):115

Tumbler Ridge Health Centre, British Columbia - Tumbler Ridge, Canada.

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http://dx.doi.org/10.4103/CJRM.CJRM_39_19DOI Listing

Pattern of antibiotic prophylaxis practice for dental procedures in children with congenital heart disease.

J Indian Soc Pedod Prev Dent 2020 Apr-Jun;38(2):126-131

Department of Paediatric Dentistry, Institute of Paediatric, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia.

Background: Various antibiotic prophylaxis guidelines have been published such as the American Heart Association 2007, British Society for Antimicrobial Chemotherapy 2006, National Institute for Health and Clinical Excellence 2008, European Society of Cardiology 2015, and in Malaysia, the National Antibiotic Guideline 2014 and Clinical Practice Guidelines for the Prevention, Diagnosis and Management of Infective Endocarditis 2017. The aim of the study is to determine the pattern of antibiotic prophylaxis practice for dental procedure in children with congenital heart disease (CHD) at the Department of Paediatric Dentistry, Kuala Lumpur Hospital.

Materials And Methods: A comparative cross-sectional study of dental records from 2010 to 2015 was done by collecting data on the source and reason of referral, types of heart condition, dental procedure, and antibiotic given. Read More

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http://dx.doi.org/10.4103/JISPPD.JISPPD_235_18DOI Listing

British Society for Rheumatology guideline for diagnosis and treatment of giant cell arteritis.

Pract Neurol 2020 Jul 1. Epub 2020 Jul 1.

Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.

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http://dx.doi.org/10.1136/practneurol-2020-002615DOI Listing

Minimal manifestation status and prednisone withdrawal in the MGTX trial.

Neurology 2020 Jul 1. Epub 2020 Jul 1.

From the Department of Neurology, University of Alabama at Birmingham, Birmingham (I.L.); the Department of Biostatistics, University of Alabama at Birmingham, Birmingham (H.-C.K., I.B.A., G.R.C., T.M., G.M); the Department of Neurology, George Washington University School of Medicine and Health Sciences, Washington, DC (H.J.K.); the Department of Neurology, Greater Manchester Neuroscience Center, Salford, Greater Manchester, UK (J.S.); the Institute of Pathology, University Medical Center Göttingen, Göttingen (P.S.); the Department of Neurology, McGill University, Montreal (C.H.C.), and the Division of Neurology, University of British Columbia, Vancouver (J. Oger) - both in Canada; the Department of Neurology, University of Chile, Santiago (G.C.); the Division of Neurology, Department of Medicine, University of Cape Town, Cape Town, South Africa (J.M.H.); the Department of Neurosciences, Mental Health and Sensory Organs, Sapienza University of Rome (G.A.), the Department of Neurology, Catholic University, (A.E.) - both in Rome; the Department of Neurology, Johannes Gutenberg University, Mainz, Germany (W.N.); the Department of Neurology, University of Rochester Medical Center, Rochester, New York (E.C.); the Division of Neurology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand (R.W.); the Department of Neurology, Royal Melbourne Hospital, Victoria, Australia (J.O.K.); the Department of Neurology, University of Southern California, Los Angeles (S.R.B.), and the Department of Neurology, University of California Irvine Medical Center, Orange (T.M.) - both in California; the Department of Neurology, Medical College of Wisconsin, Milwaukee (A.C.B.); the Department of Neurology, Harvard Medical School, Boston (A.A.A.); Nerve and Muscle Center of Texas, Houston (A.I.S.), and the Department of Neurology, University of Texas Health Science Center, San Antonio (C.E.J.) - both in Texas; the Department of Neurology, Case Western Reserve University, Cleveland (B.K.), and the Department of Neurology, Ohio State University Wexner Medical Center, Columbus (J.T.K.) - both in Ohio; Walton Centre for Neurology and Neurosurgery, Liverpool (B.R.F.L.), and Nuffield Department of Clinical Neurosciences, Oxford University, Oxford (C.B., A.V.) - both in the United Kingdom; Unit of Neurology, University of Brasilia, Brasilia (E.D.-T.), the Department of Neurology, Federal University, Rio de Janeiro (M.W.-C.), and the Department of Neurology, Universidade Federal do Parana, Curitiba (L.C.W.) - all in Brazil; the Department of Neurology, Kanazawa University, Kanazawa, Japan (H.Y.); the Department of Neurology, University of Florida, Jacksonville (M.T.P.), and the Department of Neurology, University of Miami, Miami (M.B.) - both in Florida; the Department of Neurology, Augusta University, Augusta (M.H.R.); the Department of Neurology, Medical University of Warsaw, Warsaw, Poland (A.K.-P.); the Department of Neurology, Indiana School of Medicine, Indianapolis (R.M.P.); the Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands (J.J.G.M.V.); the Department of Neurology, Duke University Medical Center, Durham, NC (J.M.M.); the Department of Neurology, University of Kansas Medical Center, Kansas City (R.J.B.); the Department of Neurological Sciences, University of Vermont College of Medicine, Burlington (R.T.); the Division of Extramural Research, National Institutes of Health, National Institute of Neurological Disorders and Stroke, Bethesda, MD (R.C.); the Section of General Thoracic Surgery, Columbia University Medical Center, New York (J.R.S.); the Department of Neurology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo (G.I.W.).

Objective: To examine whether sustained minimal manifestation status (MMS) with complete withdrawal of prednisone is better achieved in thymectomized myasthenia gravis (MG) patients.

Methods: This study is a post hoc analysis of data from the randomized trial of thymectomy in myasthenia gravis (MGTX). MGTX was a multicenter, randomized, rater-blinded 3-year trial that was followed by a voluntary 2-year extension for patients with acetylcholine receptor (AChR) antibody positive MG without thymoma. Read More

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http://dx.doi.org/10.1212/WNL.0000000000010031DOI Listing

Diagnostic accuracy of serological tests for covid-19: systematic review and meta-analysis.

BMJ 2020 Jul 1;370:m2516. Epub 2020 Jul 1.

Respiratory Epidemiology and Clinical Research Unit, Centre for Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, Canada

Objective: To determine the diagnostic accuracy of serological tests for coronavirus disease-2019 (covid-19).

Design: Systematic review and meta-analysis.

Data Sources: Medline, bioRxiv, and medRxiv from 1 January to 30 April 2020, using subject headings or subheadings combined with text words for the concepts of covid-19 and serological tests for covid-19. Read More

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http://dx.doi.org/10.1136/bmj.m2516DOI Listing

Analysis of endothelial-to-haematopoietic transition at the single cell level identifies cell cycle regulation as a driver of differentiation.

Genome Biol 2020 Jul 1;21(1):157. Epub 2020 Jul 1.

Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute, Cambridge, UK.

Background: Haematopoietic stem cells (HSCs) first arise during development in the aorta-gonad-mesonephros (AGM) region of the embryo from a population of haemogenic endothelial cells which undergo endothelial-to-haematopoietic transition (EHT). Despite the progress achieved in recent years, the molecular mechanisms driving EHT are still poorly understood, especially in human where the AGM region is not easily accessible.

Results: In this study, we take advantage of a human pluripotent stem cell (hPSC) differentiation system and single-cell transcriptomics to recapitulate EHT in vitro and uncover mechanisms by which the haemogenic endothelium generates early haematopoietic cells. Read More

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http://dx.doi.org/10.1186/s13059-020-02058-4DOI Listing

"The way I am treated is as if I am under my mother's care": qualitative study of patients' experiences of receiving hospice care services in South Africa.

BMC Palliat Care 2020 Jul 1;19(1):95. Epub 2020 Jul 1.

Department of Psychology, Stellenbosch University, Private Bag X1, Matieland, Stellenbosch, 7602, South Africa.

Background: Research on the patient experience of receiving palliative care across a number of settings is increasing, but the majority of these investigations are situated within the context of developed countries. There is limited research from resource-limited countries, especially with regard to patients with cancer who receive hospice care. The present study explored the lived experience of attending hospice care facilities in South Africa to develop a bottom-up understanding from the perspectives of patients themselves. Read More

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http://dx.doi.org/10.1186/s12904-020-00605-1DOI Listing

Choosing Educational Resources to Build Interprofessional, Palliative Care Competency: A Replicable Review Methodology.

J Palliat Care 2020 Jul 2:825859720935218. Epub 2020 Jul 2.

BC Centre for Palliative Care, New Westminster, British Columbia, Canada.

Aim/objective: The purpose of the project was to provide information to inform the choice of educational resources available in British Columbia to support palliative care competency development for 4 disciplines: nurses, physicians, health care assistants, and social workers/counsellors. This article will describe the of resource review. of the review are available at https://www. Read More

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http://dx.doi.org/10.1177/0825859720935218DOI Listing

Can Systems Thinking Become "The Way We Do Things?" Comment on "What Can Policy-Makers Get Out of Systems Thinking? Policy Partners' Experiences of a Systems-Focused Research Collaboration in Preventive Health".

Authors:
Bev J Holmes

Int J Health Policy Manag 2020 May 11. Epub 2020 May 11.

Michael Smith Foundation for Health Research, Vancouver, BC, Canada.

In "What Can Policy-Makers Get Out of Systems Thinking? Policy Partners' Experiences of a Systems-Focused Research Collaboration in Preventive Health," Haynes et al glean two important insights from the policy-makers they interview. First: active promotion of systems thinking may work against its champions. Haynes and colleagues' findings support a backgrounding of systems thinking; more important for policy-makers than understanding the finer details of systems thinking is working in situations of mutual learning and shared expertise. Read More

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http://dx.doi.org/10.34172/ijhpm.2020.70DOI Listing

Coronavirus: Where Has All the Health Economics Gone?

Int J Health Policy Manag 2020 Jun 22. Epub 2020 Jun 22.

Centre for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC, Canada.

As the coronavirus disease 2019 (COVID-19) pandemic continues to unfold there is an untold number of trade-offs being made in every country around the globe. The experience in the United Kingdom and Canada to date has not seen much uptake of health economics methods. We provide some thoughts on how this could take place, specifically in three areas. Read More

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http://dx.doi.org/10.34172/ijhpm.2020.108DOI Listing

Student-Led Initiatives' Potential in the COVID-19 Response in Iran.

Int J Health Policy Manag 2020 May 29. Epub 2020 May 29.

School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.34172/ijhpm.2020.82DOI Listing

Reimagining Researchers in Health Research Comment on "Experience of Health Leadership in Partnering With University-Based Researchers in Canada: A Call to 'Re-Imagine' Research".

Int J Health Policy Manag 2020 Jan 20. Epub 2020 Jan 20.

School of Nursing, Faculty of Health and Social Development, University of British Columbia, Kelowna, BC, Canada.

It is widely accepted that research evidence should inform policy and practice in health service organizations. Yet, amid increasingly complex and even wicked realities, where health inequities prevail and resource-strained health service organizations struggle to keep pace with demand, using research to inform practice and policy remains an elusive ideal. Bowen and colleagues' study illuminates critical relational pathways for engagement in evidence-informed practice and decision-making and suggests beginning insights into what might contribute to the tenuousness of this aspirational ideal. Read More

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http://dx.doi.org/10.15171/ijhpm.2020.05DOI Listing
January 2020

Re-imagining Research: A Bold Call, but Bold Enough? Comment on "Experience of Health Leadership in Partnering with University-Based Researchers in Canada: A Call to 'Re-Imagine' Research".

Authors:
Bev J Holmes

Int J Health Policy Manag 2019 Dec 22. Epub 2019 Dec 22.

Michael Smith Foundation for Health Research, Vancouver, BC, Canada.

Many articles over the last two decades have enumerated barriers to and facilitators for evidence use in health systems. Bowen et al's article furthers the debate by focusing on an under-explored research area (health system design and health service organization) with an under-studied stakeholder group (health system leaders), by undertaking a broad program of research on partnerships, and, based on participant responses, by calling for re-imagining of research itself. In response to the claim that the research community is not providing expertise to this pressing issue in the health system, I provide four high level reasons: partnerships mean different things to different people, our language does not reflect the reality we want, our health systems have yet to fully embrace evidence use, and complexity is easier to talk about than act within. Read More

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http://dx.doi.org/10.15171/ijhpm.2019.139DOI Listing
December 2019

Natural environments in the urban context and gut microbiota in infants.

Environ Int 2020 Jun 27;142:105881. Epub 2020 Jun 27.

Department of Pediatrics, University of Alberta, Edmonton, AB, Canada; Department of Obstetrics & Gynecology, University of Alberta, AB, Canada; School of Public Health, University of Alberta, AB, Canada; inVIVO Planetary Health, Canada. Electronic address:

The biodiversity hypothesis that contact with natural environments (e.g. native vegetation) and biodiversity, through the influence of environmental microbes, may be beneficial for human commensal microbiota has been insufficiently tested. Read More

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http://dx.doi.org/10.1016/j.envint.2020.105881DOI Listing