1,242 results match your criteria British Journal Of Biomedical Science[Journal]


Serum long noncoding RNAs FAS-AS1 & PVT1 are novel biomarkers for systemic lupus erythematous.

Br J Biomed Sci 2020 Jul 2:1-5. Epub 2020 Jul 2.

Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University Fayoum, Egypt.

Background: Systemic Lupus Erythematous (SLE) is a chronic systemic autoimmune disorder whose diagnosis depends on combination of multiple factors. Circulating lncRNAs could serve as diagnostic non-invasive biomarkers for SLE. We hypothesised that serum FAS-AS1 and PVT1 are new biomarkers for SLE that relate to clinical features and laboratory markers. Read More

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http://dx.doi.org/10.1080/09674845.2020.1765459DOI Listing

Association between polymorphism distribution frequency and blood lipid level in Chinese adults.

Br J Biomed Sci 2020 Jun 29. Epub 2020 Jun 29.

Department of Laboratory Medicine Center, Foshan Hospital of Traditional Chinese Medicine , Foshan, Guangdong, 528000, People's Republic of China.

Background: The variation of serum lipid levels can be part-related to certain genes. One such gene, , encodes a transporter that may have a role in lipid metabolism. We hypothesised that differences in certain genotypes are related to levels of serum lipids. Read More

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Toll-like receptor 7 mRNA is reduced in hepatitis C based liver cirrhosis and hepatocellular carcinoma, out-performs alpha-feto protein levels, and with age and serum aspartate aminotransferase is a new diagnostic index.

Br J Biomed Sci 2020 Jun 23. Epub 2020 Jun 23.

Chemistry Department, Faculty of Science, Helwan University , Cairo, Egypt.

Background: Hepatitis B and C viruses are leading causes of liver cirrhosis and hepatocellular carcinoma (HCC). Toll-like receptor 7 (TLR7) has been implicated in the pathogenesis of HCC linked to hepatitis B. We hypothesised a role of leukocyte TLR7 mRNA in hepatitis C related liver cirrhosis and HCC, using alpha fetoprotein (AFP) and liver function tests as comparators. Read More

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Association of miR-146a rs57095329 with Behcet's disease and its complications.

Br J Biomed Sci 2020 Jun 22. Epub 2020 Jun 22.

Medical Biochemistry and Molecular Biology Department, Fayoum University , Egypt.

Background: Behçet's disease is a chronic relapsing and remitting autoimmune multisystem inflammatory disease characterised by oral aphthae, genital ulcers, skin lesions, gastrointestinal involvement, arthritis, vascular lesions, and neurological manifestations. We hypothesised a link between rs57095329 of miR-146a and Behçet's disease, with further links with common clinical features.

Methods: We tested our hypothesis in 130 Behçet's disease patients and 131 age and sex-matched healthy controls. Read More

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Atypical and novel presentations of Coronavirus Disease 2019: a case series of three children.

Br J Biomed Sci 2020 Jun 18. Epub 2020 Jun 18.

Pediatric Infectious Disease Research Center, Tehran University of Medical Science , Tehran, Iran.

Typical presentations of Coronavirus Disease 2019 (COVID19) including respiratory symptoms (cough, respiratory distress and hypoxia), fever and dyspnea are considered main symptoms in adults, but atypical presentation children could be a diagnostic challenge We report three children whose initial presentation was gastrointestinal, and in whom COVID-19 infection was found, concluding that cases of acute appendicitis, mesenteric adenitis and flank tenderness may mask and infection with this virus, which should therefore be investigated. Read More

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A novel serum metabolome score for breast cancer diagnosis.

Br J Biomed Sci 2020 Jun 16. Epub 2020 Jun 16.

Chemistry Department, Faculty of Science, Zagazig University , Zagazig, Egypt.

Introduction: Early detection of breast cancer is helpful in the diagnosis and treatment, and so in enhancing patient survival and reducing death rates. Because of the low diagnostic sensitivity and specificity of widely used breast cancer biomarkers such as CA15-3, we hypothesised that a panel of new metabolic markers would provide superior sensitivity and specificity for this disease.

Material & Methods: We recruited 120 women cases with malignant breast cancer, 47 with benign breast disease and 55 females as a healthy control group. Read More

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Haplotype-based association study of Opioid Receptor Kappa-type 1 (OPRK1) gene polymorphisms with nicotine dependence among male smokers.

Br J Biomed Sci 2020 Jun 8. Epub 2020 Jun 8.

Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences , Rasht, Iran.

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Fine structure of the human retina defined by confocal microscopic immunohistochemistry.

Br J Biomed Sci 2020 Jun 5. Epub 2020 Jun 5.

Eye & ENT Hospital, College of Medicine, Fudan University , Shanghai 200032, China.

Introduction: Research in to the pathophysiology of the complex layers of retinal and sub-retinal cells is hampered by inadequate recognition of particular cells and tissues. A comprehensive panel of antibodies recognising retinal tissues is lacking. Our purpose was to determine the value of a panel of antibodies labelling various cells in the human retina. Read More

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Epidermal growth factor +61A/G (rs4444903) promoter polymorphism and serum levels are linked to idiopathic male infertility.

Br J Biomed Sci 2020 Jun 11:1-3. Epub 2020 Jun 11.

Department of Biology, Faculty of Sciences, University of Guilan , Rasht, Iran.

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http://dx.doi.org/10.1080/09674845.2020.1774034DOI Listing

Circulating micro RNA-223 and angiopoietin-like protein 8 as biomarkers of gestational diabetes mellitus.

Br J Biomed Sci 2020 Jul 1:1-6. Epub 2020 Jul 1.

Clinical and Chemical Pathology Department, Faculty of Medicine, Beni-Suef University , Beni-Suef, Egypt.

Background: Gestational diabetes mellitus (GDM) is a serious health problem associated with both foetal and maternal complications. New biomarkers that can predict or help in the early diagnosis of GDM are needed to minimize the hazards of hyperglycaemia in pregnant women and their offspring. We hypothesised a link between levels of microRNA-223 (miRNA-223) and Angiopoietin-Like Protein 8 (ANGPTL8) and GDM. Read More

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http://dx.doi.org/10.1080/09674845.2020.1764211DOI Listing

Association of SNP (rs2736100) with implantation failure after fertilization and embryo transfer (IVF-ET).

Br J Biomed Sci 2020 Jun 11:1-3. Epub 2020 Jun 11.

Department of Biology, Faculty of Sciences, University of Guilan , Rasht, Iran.

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http://dx.doi.org/10.1080/09674845.2020.1769332DOI Listing

Association of oestrogen receptor alpha gene SNPs Arg157Ter C>T and Val364Glu T>A with female infertility.

Br J Biomed Sci 2020 Jun 3:1-3. Epub 2020 Jun 3.

Department of Biology, Faculty of Sciences, University of Guilan , Rasht, Iran.

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http://dx.doi.org/10.1080/09674845.2020.1759993DOI Listing

Nicotinic acetylcholine receptors (rs1051730) gene polymorphism and surfactant protein D level in chronic obstructive pulmonary disease.

Br J Biomed Sci 2020 Jun 1:1-3. Epub 2020 Jun 1.

Medical Biochemistry & Molecular Biology, Faculty of Medicine, Menoufia University , Shibin Al Kawm, Egypt.

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http://dx.doi.org/10.1080/09674845.2020.1757839DOI Listing

Prognostic value of bone marrow MUC4 expression in acute myeloid leukaemia.

Br J Biomed Sci 2020 May 13:1-6. Epub 2020 May 13.

Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.

Aberrant expression of mucin-4 (MUC4) is present in a variety of solid cancers, but the expression pattern of and its clinical relevance in acute myeloid leukaemia (AML) is unknown. We aimed to evaluate the expression level of and explore its prognostic value in newly diagnosed adult patients with AML. Bone marrow from 70 AML patients and 26 healthy donors was obtained. Read More

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http://dx.doi.org/10.1080/09674845.2020.1754583DOI Listing

Demonstration of microRNA using hybridisation on formalin fixed paraffin wax samples using conventional oligonucleotide probes: a comparison with the use of locked nucleic acid probes.

Br J Biomed Sci 2020 Jul 29;77(3):135-141. Epub 2020 Apr 29.

Life Sciences, University of Westminster , London, UK.

Background: MicroRNAs (miRNAs) regulate the translation of mRNA during gene expression and investigations have highlighted their importance in pathophysiology. qRT-PCR is currently the gold standard method for detecting changes in miRNA expression. However, when used on heterogeneous samples, it cannot identify individual cell types harbouring miRNAs. Read More

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http://dx.doi.org/10.1080/09674845.2020.1748913DOI Listing

Polymorphisms rs763110 in is linked to hepatitis C virus infection among high-risk populations.

Br J Biomed Sci 2020 Jul 13;77(3):112-117. Epub 2020 May 13.

Department of Epidemiology and Biostatistics, Key Laboratory of Infectious Diseases, Nanjing Medical University , Nanjing, China.

Background: The Fas cell surface death receptor (FAS) and Fas ligand (FASL) can participate in the apoptosis of immune cells and target cells infected with a virus through the FAS-FASL signalling pathway. The decoy receptor 3 (DCR3) can competitively inhibit the binding of FAS to FASL. Our aim is to investigate the effect of single nucleotide polymorphisms (SNPs) in and on hepatitis C virus (HCV) infection. Read More

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http://dx.doi.org/10.1080/09674845.2020.1747182DOI Listing

Serum LINC00305 expression and its genetic variant rs2850711 are associated with clinical and laboratory features of rheumatoid arthritis.

Br J Biomed Sci 2020 Jul 24;77(3):142-147. Epub 2020 Apr 24.

Department of Biochemistry, Faculty of Pharmacy, Suez Canal University , Ismailia, Egypt.

Background: Long intergenic non-protein coding (lnc) RNA 00305 (LINC00305) is a pro-inflammatory atherosclerosis-associated lncRNA. We hypothesised that LINC00305 expression and its variant rs2850711 (A/T) are implicated in rheumatoid arthritis (RA) and linked with clinical and routine laboratory markers.

Methods: 100 RA patients and 100 healthy controls were recruited. Read More

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http://dx.doi.org/10.1080/09674845.2020.1744942DOI Listing

PADI4 (rs2240340), PDCD1 (rs10204525), and CTLA4 (231775) gene polymorphisms and polyarticular juvenile idiopathic arthritis.

Br J Biomed Sci 2020 Jul 13;77(3):123-128. Epub 2020 May 13.

Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University , Fayoum, Egypt.

Background: Certain single nucleotide polymorphisms (SNPs) in genes such as (coding for peptidyl arginine deiminase 4), (coding for programmed cell death 1), and (coding for cytotoxic T-lymphocyte-associated protein 4) are linked to rheumatoid arthritis (RA). However, links between SNPs rs2240340, rs10204525 and rs231775 in and respectively, and juvenile idiopathic arthritis (JIA), the commonest type of childhood arthritis, are unclear. We aimed to determine whether any of these SNPs are associated with JIA, and to clinical indices disease activity score (JADAS 71) and functional disability score (CHAQ). Read More

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http://dx.doi.org/10.1080/09674845.2020.1730626DOI Listing

The effect of CASP3 rs4647610 and rs4647602 polymorphisms on tumour size and cancer stage in papillary thyroid carcinoma.

Br J Biomed Sci 2020 Jul 13;77(3):129-134. Epub 2020 May 13.

Department of Clinical Biochemistry, Zahedan University of Medical Sciences , Zahedan, Iran.

Background: Papillary thyroid carcinoma (PTC) is the most frequent form of thyroid cancer whose incidence has increased in recent years. Dysregulated apoptosis is known in the pathogenesis of various cancers. Caspase-3 is an important apoptotic component and its abnormal function may play a key role in cancer pathogenesis. Read More

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http://dx.doi.org/10.1080/09674845.2020.1741249DOI Listing

Reduced sperm concentration in a patient from a suspected post-operative infection: a case study.

Br J Biomed Sci 2020 Jul 16;77(3):148-151. Epub 2020 Mar 16.

Fertility, X&Y Fertility , Leicester, UK.

A diagnostic semen analysis should be performed as part of a couple's routine fertility investigations in order to determine sperm quality prior to managing the treatment pathway. The semen analysis report should be considered alongside clinical discussions and a review of both patients' medical history. However, whilst it is part of the standard patient pathway, a regular up-to-date review at each clinical step of a patients' journey is not always performed, which may miss potential clinical changes that could impact the most effective management of the couple. Read More

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http://dx.doi.org/10.1080/09674845.2020.1732638DOI Listing

CAT25 defines microsatellite instability in colorectal cancer by high-resolution melting PCR.

Br J Biomed Sci 2020 Jul 13;77(3):105-111. Epub 2020 Mar 13.

Laboratorio de Biología Molecular e Histocompatibilidad, Hospital Privado Universitario de Córdoba , Córdoba, Argentina.

Background: CAT25 (Tmononucleotide repeat of the Caspase 2 gene), is a promising DNA marker for detecting microsatellite instability (MSI) in colorectal cancer. CAT25 has the potential to be incorporated into the Bethesda panel, a commonly used panel of DNA microsatellites, or replace it in its entirety. We aimed to develop and validate a high-resolution melting-PCR (HRM-PCR) method for CAT25 instability detection in clinical samples. Read More

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http://dx.doi.org/10.1080/09674845.2020.1730625DOI Listing

Upregulated miR-410 is linked to poor prognosis in colorectal cancer.

Br J Biomed Sci 2020 Jul 31;77(3):118-122. Epub 2020 Mar 31.

Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences , Tehran, Iran.

Background: Although miR-410 acts as a cancer inducer in colorectal cancer, there is limited data on the clinical implications of miR-410 expression levels in patients. We hypothesized a link between miR-410 expression and its potential clinical values in patients with colorectal cancer.

Material And Methods: 120 colorectal cancer tissue specimens and 120 adjacent non-tumour tissues were obtained. Read More

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http://dx.doi.org/10.1080/09674845.2020.1731050DOI Listing

Relevance of gene polymorphisms in susceptibility to polycystic ovary syndrome and its associated endocrine and metabolic disturbances.

Br J Biomed Sci 2020 Jun 8:1-6. Epub 2020 Jun 8.

Central Laboratory, Female Center for Scientific and Medical Colleges, King Saud University , Riyadh, Saudi Arabia.

Background: Variations in may be an emerging factor in polycystic ovary syndrome (PCOS) We hypothesised links between polymorphisms in PCOS and its associated endocrine and metabolic disturbances.

Methods: The study included 104 PCOS women and 109 controls. Endocrine (kisspeptin, LH, FSH, LH-FSH ratio, oestradiol) and metabolic (cholesterol, triglycerides, HDL, LDL, insulin and glucose) parameters were measured. Read More

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http://dx.doi.org/10.1080/09674845.2020.1726662DOI Listing

Association of rs2620381 polymorphism in miR-627 and gastric cancer.

Br J Biomed Sci 2020 Apr 27;77(2):76-80. Epub 2020 Jan 27.

Department of Radiation Oncology, Cancer Research Center, Guilan University of Medical Sciences (GUMS), Rasht, Iran.

: Gastric cancer is a complicated malignancy whose aetiology is not well characterized. Single nucleotide polymorphisms (SNPs), some located within microRNA genes, are linked with gastric cancer. We hypothesized a link between SNP rs2620381 (A > C) in miR-627 and gastric cancer. Read More

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http://dx.doi.org/10.1080/09674845.2019.1692762DOI Listing

Case report: Xanthogranulomatous pyelonephritis masquerading as cystic renal cell carcinoma.

Br J Biomed Sci 2020 Apr 24;77(2):87-90. Epub 2020 Jan 24.

Section of Urology, Department of Surgery, University of Manitoba, Winnipeg, MB, Canada.

Xanthogranulomatous pyelonephritis (XGP) is a rare chronic bacterial inflammation of the renal parenchyma and is often a diagnostic dilemma. We present a challenging case of a patient with XGP. Initially thought to have had renal cell cancer she was treated accordingly with a partial nephrectomy. Read More

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http://dx.doi.org/10.1080/09674845.2019.1662977DOI Listing

Malondialdehyde and C-reactive protein as prognostic markers of hepatocellular carcinoma.

Br J Biomed Sci 2020 Apr 25;77(2):94-96. Epub 2020 Feb 25.

Tropical Medicine Department, Mansoura University, Mansoura, Egypt.

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http://dx.doi.org/10.1080/09674845.2020.1715073DOI Listing

Cytokine gene variants and treatment outcome of cisplatin-based concomitant chemoradiotherapy in cervical cancer.

Br J Biomed Sci 2020 Apr 24;77(2):81-86. Epub 2020 Feb 24.

Molecular and Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow, India.

: Cervical cancer is the second most common cancer among women after breast cancer. Its standard treatment is cisplatin-based concomitant chemoradiotherapy. Chronic inflammation in uterine cervix triggers both pro- and anti-inflammatory pathways. Read More

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http://dx.doi.org/10.1080/09674845.2020.1714164DOI Listing

Diagnostic role of collagen-III and matrix metalloproteinase-1 for early detection of hepatocellular carcinoma.

Br J Biomed Sci 2020 Apr 6;77(2):58-63. Epub 2020 Feb 6.

Faculty of Science, Cairo University, Giza, Egypt.

: As the poor prognosis of hepatocellular carcinoma (HCC) is mostly due to late detection at an advanced stage there is a strong need for establishing more effective strategies for early identification. We hypothesized that collagen-III and matrix metalloproteinase-1 (MMP-1) and their ratio (CMR) are effective markers for identifying early-HCC when used alongside serum AFP, alkaline phosphatase and bilirubin.: We recruited 148 patients with HCC, 133 with cirrhosis and 121 with fibrosis. Read More

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http://dx.doi.org/10.1080/09674845.2019.1708534DOI Listing

Bilateral spontaneous renal artery dissection and antiphospholipid antibodies.

Br J Biomed Sci 2020 Apr 13;77(2):101-104. Epub 2020 Feb 13.

Facoltà di Medicina e Psicologia, Dipartimento di Medicina Clinica e Molecolare, UOC Medicina Interna, Sapienza Università di Roma, Ospedale Sant'Andrea, Roma, Italia.

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http://dx.doi.org/10.1080/09674845.2019.1708535DOI Listing

(rs3810936) in Behçet's disease.

Br J Biomed Sci 2020 07 11;77(3):156-158. Epub 2020 Feb 11.

Department of Rheumatology, Faculty of Medicine, Zagazig University , Zagazig, Egypt.

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http://dx.doi.org/10.1080/09674845.2019.1710910DOI Listing

British Journal of Biomedical Science in 2019. What have we learned?

Authors:
A Blann

Br J Biomed Sci 2020 Jan 10;77(1):1-6. Epub 2019 Dec 10.

Institute of Biomedical Science, London, UK.

In 2019 the British Journal of Biomedical Science published 40 articles in the various disciplines that comprise biomedical science. These were one review, 22 original articles and 17 'In Brief' short reports. Of those citing original data, the majority were in cellular pathology (14 papers), clinical chemistry (9 papers), and microbiology (6 papers: 4 in bacteriology and 2 in virology). Read More

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http://dx.doi.org/10.1080/09674845.2019.1692455DOI Listing
January 2020

Methylation of tumour suppressor genes and in HCV-related liver cirrhosis and hepatocellular carcinoma.

Br J Biomed Sci 2020 Jan 2;77(1):35-40. Epub 2019 Dec 2.

Medical Biochemistry Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

: HCV infection is related to aberrant methylation of several genes. and are tumour suppressor genes that may be inactivated by hypermethylation in many tumours including hepatocellular carcinoma (HCC). We hypothesized that methylation is a diagnostic biomarker for HCC in patients with HCV-related liver cirrhosis. Read More

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http://dx.doi.org/10.1080/09674845.2019.1694123DOI Listing
January 2020

Synergic effects of cancer stem cells markers, CD44 and embryonic stem cell transcription factor Nanog, on bladder cancer prognosis.

Br J Biomed Sci 2020 Apr 20;77(2):69-75. Epub 2019 Dec 20.

Research Metabolic Unit, Era's Lucknow Medical College & Hospital, Era University, Lucknow, India.

: Therapy that targets cancer stem cells has the potential to eradicate cancer and prevent tumour recurrence. Therefore, we hypothesized the combined prognostic significance of stem cell markers CD44 (prevalent in basal layer of urothelial carcinoma) and Nanog (embryonic stem cell transcription factor) in bladder cancer.: CD44 and Nanog expression were determined by immunohistochemistry in 112 bladder cancer cases of which 79 were non-muscle invasive and 33 muscle invasive. Read More

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http://dx.doi.org/10.1080/09674845.2019.1692761DOI Listing

Apa1 (rs7975232) SNP in the vitamin D receptor is linked to hepatocellular carcinoma in hepatitis C virus cirrhosis.

Br J Biomed Sci 2020 Apr 25;77(2):53-57. Epub 2019 Nov 25.

Tropical Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

: As hepatocellular carcinoma (HCC) arising from chronic hepatitis C virus (HCV) infection in liver cirrhosis is a major problem in public health, early and rapid prediction of HCC is urgent. We hypothesized that a single nucleotide polymorphism in the SNP in the vitamin D receptor may help diagnosis.: We recruited 3 groups: 80 HCC patients with HCV cirrhosis, 80 HCV cirrhotic patients free of HCC and 80 healthy controls. Read More

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http://dx.doi.org/10.1080/09674845.2019.1680166DOI Listing
April 2020
1 Read

Links between SNPs in and and idiopathic recurrent pregnancy loss.

Br J Biomed Sci 2020 Apr 21;77(2):64-68. Epub 2019 Nov 21.

Faculty of Sciences, El Manar University, Tunis, Tunisia.

: Recurrent pregnancy loss is a serious complication of pregnancy and failure of the innate immune system, one part of which are toll-like receptors (TLRs). We hypothesised links between variants of and with recurrent pregnancy loss.: We recruited 335 women with recurrent pregnancy loss, defined as ≥3 consecutive spontaneous miscarriage of unknown aetiology, and 331 age-matched control women. Read More

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http://dx.doi.org/10.1080/09674845.2019.1687151DOI Listing

Single nucleotide polymorphisms rs12979860 and rs8099917 in IL-28B and spontaneous clearance of hepatitis C genotype 4.

Br J Biomed Sci 2020 Apr 13;77(2):91-93. Epub 2019 Nov 13.

Clinical Pathology Department, Faculty of Medicine, Menoufia University, Shibin el Kom, Egypt.

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http://dx.doi.org/10.1080/09674845.2019.1683310DOI Listing

polymorphism is linked to breast cancer.

Br J Biomed Sci 2020 Jan 18;77(1):29-34. Epub 2019 Nov 18.

Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran.

: MicroRNAs (miRNAs) participate in gene regulation and the control of cancer-related mechanisms such as apoptosis, invasion and differentiation. Single nucleotide polymorphisms (SNP) of the miRNA encoding genes may influence the development of cancer. We hypothesized a link between SNP and breast cancer. Read More

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http://dx.doi.org/10.1080/09674845.2019.1683309DOI Listing
January 2020

Non-coding RNAs - A primer for the laboratory scientist.

Authors:
P Waller A D Blann

Br J Biomed Sci 2019 Oct;76(4):157-165

Institute of Biomedical Science, London, UK.

Advances in molecular genetics have identified several species of RNA that fail to translate - hence the non-coding RNAs. The two major groups within this class of nucleic acids are microRNAs (miRNA) and long non-coding RNAs (lncRNA). There is growing body of evidence supporting the view that these molecules have regulatory effect on both DNA and RNA. Read More

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http://dx.doi.org/10.1080/09674845.2019.1675847DOI Listing
October 2019

Relationship of the expression of circulating and with breast cancer.

Br J Biomed Sci 2020 Jan 23;77(1):41-43. Epub 2019 Dec 23.

Department of Breast Diseases, Ghaem Hospital, Rasht, Iran.

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http://dx.doi.org/10.1080/09674845.2019.1674470DOI Listing
January 2020

Association of SNPs in with idiopathic and secondary membranous nephropathy in two Chinese cohorts.

Br J Biomed Sci 2020 Jan 21;77(1):24-28. Epub 2019 Oct 21.

Laboratory Medicine Centre, Nanfang Hospital, Southern Medical University, Guangzhou, China.

: Specific single-nucleotide polymorphisms (SNPs) in the M-type phospholipase A2 receptor-1 () are associated with increased risk of idiopathic membranous nephropathy (IMN) in European populations. We hypothesized links between IMN and SMN with these SNPs in two Chinese cohorts.: A cohort of 166 IMN patients and 144 controls from southern China (Group A) and a cohort of 212 IMN patients, 118 SMN patients, and 162 controls from northwestern China (Group B) were recruited. Read More

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http://dx.doi.org/10.1080/09674845.2019.1666783DOI Listing
January 2020
1 Read

Elevated serum alkaline phosphatase in epilepsy: effect of age and treatment.

Br J Biomed Sci 2020 Jan 4;77(1):44-47. Epub 2019 Oct 4.

Institute of Genomics and Integrative Biology (IGIB), Council of Scientific and Industrial Research (CSIR), Delhi, India.

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http://dx.doi.org/10.1080/09674845.2019.1663781DOI Listing
January 2020

, Calpain 10 SNP 19 and indices of glycaemia in type 2 diabetes.

Br J Biomed Sci 2019 Oct 11;76(4):205-207. Epub 2019 Sep 11.

Department of Biochemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt.

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http://dx.doi.org/10.1080/09674845.2019.1660501DOI Listing
October 2019

Clinical diagnostic significance of 14-3-3η protein, high-mobility group box-1, anti-cyclic citrullinated peptide antibodies, anti-mutated citrullinated vimentin antibodies and rheumatoid factor in rheumatoid arthritis.

Br J Biomed Sci 2020 Jan 16;77(1):19-23. Epub 2019 Sep 16.

Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.

: Circulating markers of rheumatoid arthritis (RA) include the 14-3-3η protein, high-mobility group box-1 (HMGB1), anti-cyclic citrullinated peptide (anti-CCP) antibodies, anti-mutated citrullinated vimentin (anti-MCV) antibodies and rheumatoid factor (RF). We set out to determine which two markers in combination provided best discriminatory power for this disease.: We recruited 108 RA patients, 102 non-RA patients (SLE, AS, Sjogren's syndrome, MCTD) and 90 healthy controls. Read More

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http://dx.doi.org/10.1080/09674845.2019.1658425DOI Listing
January 2020
2 Reads

Rapidly progressive case of type I Madelung disease with bilateral parotid and minor salivary glands involvement.

Br J Biomed Sci 2020 Jan 6;77(1):48-52. Epub 2019 Sep 6.

Department of Radiology, 'Mother Teresa' UHC, Tirane, Albania.

Madelung disease has been literally classified as a rare disease, more common in Mediterranean population. It is characterized by the presence of multiple symmetrical, non-capsulated storages of adipose tissue. We present a 56 year old woman with a sudden unexplained progression of swelling in the neck and upper thorax region associated with severe dyspnea. Read More

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http://dx.doi.org/10.1080/09674845.2019.1656497DOI Listing
January 2020
1 Read

Hepatitis C virus core antigen as a possible alternative for evaluation of treatment effectiveness after treatment with direct-acting antivirals.

Br J Biomed Sci 2019 Oct 6;76(4):190-194. Epub 2019 Sep 6.

Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Bialystok, Poland.

: Chronic hepatitis C is a major public health problem around the world. In monitoring treatment efficacy, although costly and labour-intensive methods of molecular biology are often used, much cheaper and technically easier serological methods evaluating the concentration of HCV core antigen in serum are available. We evaluated HCVcAg quantification as a possible assessment of the treatment efficacy instead of HCV RNA quantification. Read More

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http://dx.doi.org/10.1080/09674845.2019.1654790DOI Listing
October 2019
1 Read

Role of extracellular matrix remodelling gene SNPs in keratoconus.

Br J Biomed Sci 2020 Jan 29;77(1):13-18. Epub 2019 Aug 29.

Basic medical sciences Department, Faculty of Medicine, Hashemite University, Zarqa, Jordan.

: Single nucleotide polymorphisms (SNPs) in genes for certain structural components may be implicated in the pathogenesis of keratoconus. We hypothesized links between SNPs in genes coding for collagen, matrix metalloproteinase 9 (MMP9) and tissue inhibitor of matrix metalloproteinase (TIMP) and keratoconus. Furthermore, we hypothesized links between MMP-9 and TIMP-1 SNPs and their tear level in keratoconus patients. Read More

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http://dx.doi.org/10.1080/09674845.2019.1654346DOI Listing
January 2020

-572G/C and -174G/C polymorphisms association with hepatitis C virus-induced hepatocellular carcinoma.

Br J Biomed Sci 2019 Oct 7;76(4):201-204. Epub 2019 Aug 7.

Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

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http://dx.doi.org/10.1080/09674845.2019.1642562DOI Listing
October 2019

miR-15a: a potential diagnostic biomarker and a candidate for non-operative therapeutic modality for age-related cataract.

Br J Biomed Sci 2019 Oct 14;76(4):184-189. Epub 2019 Aug 14.

Community Medicine and Public Health, Faculty of Medicine, Benha University, Benha, Egypt.

In order to better understand the role of hsa-miR-15a in the pathogenesis of age-related cataracts, we hypothesised altered expression, and of target anti-apoptotic genes, and , in lens epithelial cells amongst age-related cataract patients. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) quantified the expression of hsa-miR-15a and the target genes and in lens epithelial cells of 120 age-related cataract patients (40 patients with cortical cataracts, 40 patients with nuclear cataracts and 40 patients with posterior subcapsular cataracts) and 40 controls. Sixty specimens (15 normal and 45 cataracts) were stained immunohistochemically with and markers. Read More

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http://dx.doi.org/10.1080/09674845.2019.1639337DOI Listing
October 2019
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