1,186 results match your criteria British Journal Of Biomedical Science[Journal]


The rivaroxaban-adjusted normalized ratio: Use of the prothrombin time to monitor the therapeutic effect of rivaroxaban.

Br J Biomed Sci 2019 Apr 10. Epub 2019 Apr 10.

b Department of Laboratory Medicine , University of Ulsan College of Medicine and Asan Medical Center , Seoul , Korea.

Background: The prothrombin time may be used to monitor the plasma concentration of rivaroxaban. However, there is variability in the responsiveness to rivaroxaban to different thromboplastins. We aimed to develop a rivaroxaban-monitoring method using the prothrombin time to reduce the differences in the sensitivity among reagents. Read More

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Identification and characterisation of anti - Pseudomonas aeruginosa proteins in mucus of the brown garden snail, Cornu aspersum.

Br J Biomed Sci 2019 Apr 10. Epub 2019 Apr 10.

c School of Natural Sciences and Psychology , Liverpool John Moores University , Byrom Street, Liverpool L3 3AF , UK.

Background Novel antimicrobial treatments are urgently needed. Previous work has shown that the mucus of the brown garden snail (Cornu aspersum) has antimicrobial properties, in particular against type culture collection strains of Pseudomonas aeruginosa. We hypothesised that it would also be effective against clinical isolates of the bacterium and that investigation of fractions of the mucus would identify one or more proteins with anti-pseudomonal properties, which could be further characterised. Read More

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A panel of a mitogenic (PDGF), biochemical (albumin) and demographic (age) parameters for the noninvasive assessment of hepatic fibrosis.

Br J Biomed Sci 2019 Mar 29. Epub 2019 Mar 29.

e Faculty of medicine, department of endemic medicine and hepatology , Cairo University , Egypt.

Background: Several studies have investigated certain fibrosis markers that incorporate liver function tests, fragments of liver-matrix components, and/or degraded products generated by hepatic stellate cells for determining the degree of hepatic fibrosis. However, the role of these molecules in the development of hepatic fibrosis is unclear. This work aimed (a) to determine whether levels of platelet-derived growth factor (PDGF) are linked to different stages of hepatic fibrosis, and (b) investigate its diagnostic performance as an adjunct to other laboratory and demographic factors for assessing the degree of liver fibrosis in chronic hepatitis C infection. Read More

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March 2019
2 Reads

Clinical significance of serum miR-25 in non-small-cell lung cancer.

Authors:
J Li M Yu Z Liu B Liu

Br J Biomed Sci 2019 Mar 28. Epub 2019 Mar 28.

d Department of Thoracic surgery , the central hospital of Linyi, Yishui , Shangdong , China .

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March 2019
1 Read

ABCB1 2677G>T single nucleotide polymorphism influences warfarin dose requirement for warfarin maintenance therapy.

Br J Biomed Sci 2019 Mar 25. Epub 2019 Mar 25.

a Department of Pharmacology , JIPMER , Puducherry 605006 , India.

This work represents an advance in biomedical science because it shows, in a singlecentre study of 210 patients, an association between ABCB1 2677 G>T genetic polymorphism and the maintenance dose requirement of warfarin for patients who have achieved a stable INR. Hence incorporation of this polymorphism to algorithms for dose prediction of warfarin may improve the accuracy of dose prediction. Read More

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Interaction of antioxidant gene variants and susceptibility to Type 2 Diabetes Mellitus.

Br J Biomed Sci 2019 Mar 22. Epub 2019 Mar 22.

c Department of Physiology , King George's Medical University , Lucknow , Uttar Pradesh , India - 226003.

Background: Diabetes is the seventh most common disease leading to death with a global estimate of 425 million diabetics, which is expected to be 629 million in 2045. The role of reactive metabolites and antioxidants, such as glutathione, glutathione peroxidase, superoxide dismutase and catalase in type 2 diabetes mellitus (T2DM) provides an opportunity for identifying gene variants and risk genotypes. We hypothesised that certain antioxidant gene-gene interactions are linked to susceptibility to T2DM and so can model disease risk prediction. Read More

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Pushing the boundaries of in situ hybridisation for mRNA demonstration: Demonstration of kappa and lambda light chain restriction in follicular lymphoma.

Br J Biomed Sci 2019 Mar 20. Epub 2019 Mar 20.

a Life sciences, University of Westminster , London , United Kingdom.

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March 2019
1 Read

Association of GSTP1 gene polymorphism with diabetic nephropathy and co-morbidities (hypertension and dyslipidemia) in Type 2 diabetes mellitus.

Br J Biomed Sci 2019 Mar 18. Epub 2019 Mar 18.

a Department of Biochemistry , Medicine Era's Lucknow Medical College and Hospital , Lucknow , India.

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March 2019
1 Read

Long noncoding RNA Xist predicts the presence of lymph node metastases in human esophageal squamous cell carcinoma.

Authors:
J Li D He

Br J Biomed Sci 2019 Mar 18. Epub 2019 Mar 18.

b Department of Internal Medicine , the affiliated hospital of Qingdao University , Qingdao , Shangdong , China .

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Immunohistochemical Detection of V600E BRAF Mutation is a Useful Primary Screening Tool for Malignant Melanoma.

Br J Biomed Sci 2019 Mar 14. Epub 2019 Mar 14.

c Dermatopathology Department, St. John's Institute of Dermatology, St. Thomas' Hospital.

Background: The use of immunohistochemical (IHC) methods employing a monoclonal antibody BRAF V600E which detects the main BRAF mutation in metastatic malignant melanoma is assessed in 71 malignant melanoma patients and compared to DNA probe screening, in a blind trial.

Material And Methods: The respective paraffin blocks were cut with one Haematoxylin and Eosin staying technique (H&E) and one consecutive unstained slide. The unstained slide contained known positive micro array control material. Read More

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Genetic polymorphisms in DNA repair genes and their association with cervical cancer.

Br J Biomed Sci 2019 Mar 14. Epub 2019 Mar 14.

a Molecular and Human Genetics Laboratory, Department of Zoology , University of Lucknow , Lucknow - 226007 , Uttar Pradesh , India .

Background & Objective: Carcinoma of cervix is the second most common cancer among women worldwide. The DNA repair network plays an important role in the maintenance of genetic stability, protection against DNA damage and carcinogenesis. Alterations in repair genes XRCC1, XRCC2 and XRCC3 and been reported in certain cancers. Read More

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March 2019
1 Read

Clinicopathological impact of anti-smooth muscle antibodies in patients with non-alcoholic fatty liver disease.

Br J Biomed Sci 2019 Jan 31:1-3. Epub 2019 Jan 31.

a Tropical Medicine Department, Faculty of Medicine , Mansoura University , Mansoura , Egypt.

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http://dx.doi.org/10.1080/09674845.2019.1575532DOI Listing
January 2019
6 Reads

The Association of Hepatic Fat Percentage With Selected Anthropometric And Biochemical Parameters At 3 Tesla Magnetic Resonance Imaging.

Br J Biomed Sci 2019 Jan 29. Epub 2019 Jan 29.

f Department of Medical Laboratory Sciences, Faculty of Applied Health Sciences , The Hashemite University , Zarqa , Jordan.

Background And Aim: This relatively comprehensive and multi-parametric study was conducted to investigate any association between hepatic fat percentage (HFP) values measured using high-field MRI, anthropometric and biochemical measurements in a group of disease-free adults.

Methods: Abdominal MRI, anthropometric and biochemical measurements were determined in 167 healthy subjects. HFP values were derived from the MRI, whilst routine lipids, leptin, resistin, IL6 and adiponectin were measured by routine methods. Read More

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January 2019

Lactobacillus casei suppresses hfq gene expression in Escherichia coli O157:H7.

Br J Biomed Sci 2019 Jan 11:1-3. Epub 2019 Jan 11.

b Immunology Research Center , Tabriz University of Medical Sciences , Tabriz , Iran.

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http://dx.doi.org/10.1080/09674845.2019.1567903DOI Listing
January 2019
1 Read

BMP4 circulating levels and promoter (rs17563) polymorphism in risk prediction of idiopathic male infertility.

Br J Biomed Sci 2019 Jan 10:1-3. Epub 2019 Jan 10.

a Department of Biology, Faculty of Sciences , University of Guilan , Rasht , Iran.

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http://dx.doi.org/10.1080/09674845.2018.1564419DOI Listing
January 2019
4 Reads

Inverse relationship between cagG-positive Helicobacter pylori status and risk of gastric ulcer.

Br J Biomed Sci 2019 Jan 8:1-3. Epub 2019 Jan 8.

b Digestive Diseases Research Center , Ardabil University of Medical Sciences , Ardabil , Iran.

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http://dx.doi.org/10.1080/09674845.2018.1564418DOI Listing
January 2019
1 Read

A single-nucleotide polymorphism in TLR4 is linked with the risk of HIV-1 infection.

Br J Biomed Sci 2018 Dec 20:1-5. Epub 2018 Dec 20.

a Department of Microbiology , Sanjay Gandhi Post Graduate Institute of Medical Sciences , Lucknow , India.

Introduction: Toll-like receptors (TLRs) are pattern recognition receptors that play a role in innate immunity. Mounting evidence shows that single-nucleotide polymorphisms (SNPs) in TLRs link to various infectious diseases, including human immunodeficiency virus (HIV). We hypothesized links between two TLR4 SNPs (rs4986790 leading to Asp299Gly and rs4986791 leading to Thr399Ile) and HIV, to investigate the frequency of TLR4 polymorphism and its role in patients infected with HIV. Read More

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http://dx.doi.org/10.1080/09674845.2018.1559486DOI Listing
December 2018
9 Reads

The severity of NAFLD is associated with the risk of urolithiasis.

Br J Biomed Sci 2018 Nov 15. Epub 2018 Nov 15.

b Department of Urology , the First Hospital of Jilin University , Changchun 130000 , China .

Background And Aims: Population-based studies suggest a strong association between the presence of nonalcoholic fatty liver disease (NAFLD) and an increased risk of urolithiasis. However, the available information on the association of the severity of NAFLD with urolithiasis is limited. We hypothesised a link between the severity of NAFLD and the risk of urolithiasis. Read More

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November 2018
54 Reads

TLR3 and TLR4 SNP variants in the liver disease resulting from hepatitis B virus and hepatitis C virus infection.

Br J Biomed Sci 2019 Jan 3;76(1):35-41. Epub 2018 Dec 3.

f Faculty of Sciences of Tunis, Laboratory of Mycology , University of Tunis El Manar , Tunis , Tunisia.

Background: Chronic infection with hepatitis B (HBV) and C virus (HCV) is linked with a pro-inflammatory state, predisposing to cirrhosis and liver cancer, particularly hepatocellular carcinoma (HCC). A role for Toll-like receptor (TLR) signalling in hepatocarcinogenesis was recently documented. We hypothesised a link TLR3 and TLR4 polymorphisms and HCC, as surrogates for the significance of TLR signalling in the promotion and initiation of HCC. Read More

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http://dx.doi.org/10.1080/09674845.2018.1547179DOI Listing
January 2019
13 Reads

Influence of single nucleotide polymorphism in IL-27 and IL-33 genes on breast cancer.

Br J Biomed Sci 2018 Nov 8. Epub 2018 Nov 8.

k Immunology Research Center, Tabriz University of Medical Sciences , Tabriz , Iran.

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November 2018
2 Reads

Genetic polymorphism of glial cell-derived neurotrophic factor (GDNF) in male infertility.

Br J Biomed Sci 2018 Nov 8:1-3. Epub 2018 Nov 8.

a Department of Biology, Faculty of Sciences , University of Guilan , Rasht , Iran.

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http://dx.doi.org/10.1080/09674845.2018.1545553DOI Listing
November 2018

Clinical diagnostic significance of prealbumin, cholinesterase and retinol binding protein in liver cirrhosis combined with encephalopathy.

Br J Biomed Sci 2019 Jan 5;76(1):24-28. Epub 2018 Nov 5.

a Department of Clinical Laboratory Science, Jiangxi Province Key Laboratory of Laboratory Medicine , the Second Affiliated Hospital of Nanchang University , Nanchang , Jiangxi , China.

Objective: Hepatic encephalopathy is a common consequence of liver cirrhosis, but diagnosis can be difficult as it is based on clinical criteria alone. We hypothesised that serum prealbumin, cholinesterase and retinol binding protein (RBP) can help support the diagnosis of hepatic encephalopathy.

Methods: We enrolled 306 cirrhotic patients (110 with encephalopathy), 100 chronic hepatitis B patients and 50 healthy controls, measuring routine liver function tests (ALT, AST, GGT, ALP, and bilirubin), albumin, prothrombin time, prealbumin, cholinesterase and RBP by routine methods. Read More

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https://www.tandfonline.com/doi/full/10.1080/09674845.2018.1
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http://dx.doi.org/10.1080/09674845.2018.1523673DOI Listing
January 2019
13 Reads

Nitrosative stress and cytokines are linked with the severity of sepsis and organ dysfunction.

Br J Biomed Sci 2019 Jan 16;76(1):29-34. Epub 2018 Nov 16.

a Amity Institute of Biotechnology , Amity University Rajasthan , Jaipur , India.

Objective: An imbalance in oxidant-antioxidant status may impact the severity of sepsis. We hypothesised links between nitrosative stress and pro-inflammatory cytokines and their correlation with the severity of sepsis and associated organ dysfunction.

Methods: The hypothesis was tested in 110 patients with sepsis (in whom a disease severity score (APACHE II) and assessment of organ failure score (SOFA) were determined) and 55 healthy volunteers. Read More

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http://dx.doi.org/10.1080/09674845.2018.1543160DOI Listing
January 2019
17 Reads

British Journal of Biomedical Science in 2018: what have we learned?

Authors:
A Blann

Br J Biomed Sci 2018 Oct 8:1-10. Epub 2018 Oct 8.

a Institute of Biomedical Science , London , UK .

In 2018 the British Journal of Biomedical Science published one guideline (in reproductive science) and 40 research articles in the various disciplines the comprise biomedical science. The latter were 24 original articles and 16 'In Brief' short reports. Of these, 23 are of note to only one of the sub-disciplines (seven each to biochemists and microbiologists, six to cell pathologists, and one each to cytologists, immunologists and reproductive scientists). Read More

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http://dx.doi.org/10.1080/09674845.2018.1533702DOI Listing
October 2018

A functional genetic variant in GAS5 lncRNA (rs145204276) modulates p27 expression and confers risk for gastric cancer.

Br J Biomed Sci 2018 Oct 1:1-3. Epub 2018 Oct 1.

b Department of Biology, Faculty of Sciences , University of Guilan , Rasht , Iran.

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http://dx.doi.org/10.1080/09674845.2018.1530581DOI Listing
October 2018
3 Reads

Association of SDF1β (G801A) and GNB3 (C825T) polymorphisms with the incidence and severity of coronary artery disease.

Br J Biomed Sci 2018 Sep 26:1-3. Epub 2018 Sep 26.

a Department of Biochemistry , Era's Lucknow Medical College and Hospital , Lucknow , India.

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http://dx.doi.org/10.1080/09674845.2018.1527802DOI Listing
September 2018
2 Reads

Role of variants rs5030717 and rs5030718 of TLR4 in the risk prediction of nephropathy, hypertension and dyslipidaemia in type 2 diabetes mellitus.

Br J Biomed Sci 2018 Oct 13;75(4):163-168. Epub 2018 Sep 13.

a Department of Biochemistry , Era's Lucknow Medical College and Hospital , Lucknow , India.

Background: Type 2 diabetes mellitus describes a metabolic disorder characterised by prolonged elevated blood glucose that brings a risk of developing microvascular and macrovascular disease. Several factors, such as dysregulation of the Toll-like receptor 4 (TLR-4), are reputed to contribute to the multiple pathophysiological disturbances responsible for impaired glucose homeostasis. We hypothesised that variants rs5030717 and rs5030718 of TLR4 are associated with diabetic nephropathy, hypertension and dyslipidaemia. Read More

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http://dx.doi.org/10.1080/09674845.2018.1477033DOI Listing
October 2018
1 Read

microRNA-935 is reduced in non-small cell lung cancer tissue, is linked to poor outcome, and acts on signal transduction mediator E2F7 and the AKT pathway.

Br J Biomed Sci 2019 Jan 30;76(1):17-23. Epub 2018 Oct 30.

a Respiratory Medicine Department , The First Affiliated Hospital of JIAMUSI University , Jia Mu Si , PR China.

Background: A potential role for microRNA-935 (miR-935) has been identified in several cancers but not in non-small cell lung cancer (NSCLC). We hypothesised changes in miR-935 in NSCLC, and proposed mechanisms that may further explain its role in carcinogenesis.

Methods: NSCLC tissue and nearby normal tissue was obtained from 101 patients and was probed by qRT-PCR for miR-935 expression. Read More

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http://dx.doi.org/10.1080/09674845.2018.1520066DOI Listing
January 2019
2 Reads

Association of genetic polymorphisms of chemokines and their receptors with clearance or persistence of hepatitis C virus infection.

Br J Biomed Sci 2019 Jan 29;76(1):11-16. Epub 2018 Oct 29.

g Endemic Medicine and Endemic Hepatogastroenterology Department, Faculty of Medicine , Cairo University , Cairo , Egypt.

Background: Polymorphisms of certain genes may have an effect on either persistence of infection or spontaneous clearance of hepatitis C virus (HCV). We hypothesized that one or more variants of chemokines (CCL2 and CCL5) and chemokine receptors (CC chemokine receptor type 2 [CCR2]) genes are associated with the susceptibility to HCV infection.

Methods: We recruited 1460 patients with chronic HCV (CHC), 108 subjects with spontaneous virus clearance (SVC) and 1446 individuals as a healthy control group. Read More

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http://dx.doi.org/10.1080/09674845.2018.1518299DOI Listing
January 2019

BPI-ANCA in chronic obstructive pulmonary disease with pulmonary Pseudomonas aeruginosa colonisation: a novel indicator of poor prognosis.

Br J Biomed Sci 2018 Oct 13;75(4):206-208. Epub 2018 Sep 13.

a Department of Clinical Laboratory, Jiangxi Province Key Laboratory of Laboratory Medicine , the Second Affiliated Hospital of Nanchang University , Nanchang , China.

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http://dx.doi.org/10.1080/09674845.2018.1512260DOI Listing
October 2018
19 Reads

SNP rs10800708 within the KIF14 miRNA binding site is linked with breast cancer.

Br J Biomed Sci 2019 Jan 26;76(1):46-48. Epub 2018 Oct 26.

b Department of Biology, School of Sciences , University of Isfahan , Isfahan , Iran.

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http://dx.doi.org/10.1080/09674845.2018.1509551DOI Listing
January 2019
5 Reads

Serum leptin and homeostasis model assessment-IR as novel predictors of early liver fibrosis in chronic hepatitis B virus infection.

Br J Biomed Sci 2018 Oct 7;75(4):192-196. Epub 2018 Sep 7.

c Department of Medical Microbiology and Immunology , Mansoura University , Mansoura , Egypt.

Background: The relationship between hepatitis B virus (HBV) infection, leptin and insulin resistance remains unclear. We hypothesised links between serum leptin and insulin resistance in non-diabetic patients with chronic viral hepatitis B infection and their relation to liver fibrosis.

Methods: We recruited 190 untreated patients with chronic HBV infection and 72 healthy controls. Read More

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http://dx.doi.org/10.1080/09674845.2018.1505187DOI Listing
October 2018
2 Reads

Prognostic significance of soluble major histocompatibility complex class I-related chain A (sMICA) in gastric cancer.

Authors:
P Zhao D Chen H Cheng

Br J Biomed Sci 2018 Oct 6;75(4):203-205. Epub 2018 Sep 6.

a Department of General Surgery , The Affiliated Hospital of Qingdao University , Qingdao , Shandong , China.

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http://dx.doi.org/10.1080/09674845.2018.1505188DOI Listing
October 2018

Development of a multiplex two-gene real-time PCR assay for accurate detection of Klebsiella pneumoniae.

Br J Biomed Sci 2019 Jan 22;76(1):42-45. Epub 2018 Aug 22.

a Department of Clinical Laboratory , Shenzhen Shajing Hospital affiliated to Guangzhou Medical University , Shenzhen , China.

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http://dx.doi.org/10.1080/09674845.2018.1499167DOI Listing
January 2019
23 Reads

Monocyte/granulocyte to lymphocyte ratio and the MELD score as predictors for early recurrence of hepatocellular carcinoma after trans-arterial chemoembolization.

Br J Biomed Sci 2018 Oct 21;75(4):187-191. Epub 2018 Aug 21.

a Tropical Medicine Department.

Background: The first-line treatment option for intermediate-stage hepatocellular carcinoma is trans-arterial chemoembolization (TACE). Blood indices, such as lymphocyte/monocyte ratio (LMR), lymphocyte count, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte-granulocyte/lymphocyte ratio (MGLR) and red blood cell distribution width (RDW), are prognostic biomarkers in certain diseases. The model for end-stage liver disease (MELD) and Child-Turcotte-Pugh (CTP) scores have been designed for patients with cirrhosis waiting for liver transplantation and in patients with hepatocellular carcinoma. Read More

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http://dx.doi.org/10.1080/09674845.2018.1494769DOI Listing
October 2018
24 Reads

A method for improving the accuracy of non-invasive prenatal screening by cell-free foetal DNA size selection.

Br J Biomed Sci 2018 Jul;75(3):133-138

a Center for Reproduction and Genetics , The Affiliated Suzhou Hospital of Nanjing Medical University , Suzhou , China.

Background Non-invasive prenatal screening (NIPS) using cell-free foetal DNA (cfDNA) has been widely used for identifying common foetal aneuploidies (e.g. trisomy 21 (T21), trisomy (T18) and trisomy 13 (T13)) in clinical practice. Read More

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http://dx.doi.org/10.1080/09674845.2018.1468152DOI Listing
July 2018
7 Reads

The association of single nucleotide polymorphisms of Toll-like receptor 3, Toll-like receptor 7 and Toll-like receptor 8 genes with the susceptibility to HCV infection.

Br J Biomed Sci 2018 Oct 23;75(4):175-181. Epub 2018 Aug 23.

i Endemic Medicine and Endemic Hepatogastroenterology Department, Faculty of Medicine , Cairo University , Cairo , Egypt.

Background: Single nucleotide polymorphisms (SNPs) of Toll-like receptors (TLRs) are linked with functional modification of cytokine responses. In chronic hepatitis C virus (HCV) infection, studies of TLR polymorphisms have primarily targeted receptor pathways implicated in viral immune responses. We hypothesized that one or more variant(s) of TLR3, TLR7 and TLR8 are associated with different outcomes of HCV infection. Read More

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http://dx.doi.org/10.1080/09674845.2018.1492186DOI Listing
October 2018
7 Reads

Impact of non-alcoholic fatty liver disease on pregnancy.

Br J Biomed Sci 2018 Oct 6;75(4):197-199. Epub 2018 Aug 6.

e Medical Microbiology and Immunology Department , Mansoura University , Mansoura , Egypt.

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https://www.tandfonline.com/doi/full/10.1080/09674845.2018.1
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http://dx.doi.org/10.1080/09674845.2018.1492205DOI Listing
October 2018
6 Reads

Influence of single nucleotide polymorphisms in pri-miR-124-1 and STAT3 genes on gastric cancer susceptibility.

Br J Biomed Sci 2018 Oct 17;75(4):182-186. Epub 2018 Aug 17.

b Department of Radiation Oncology , Cancer Research Center, Guilan University of Medical Sciences (GUMS) , Rasht , Iran.

Introduction: MicroRNAs (miRNAs) are small ribonucleic acids that modulate the expression of downstream target genes. There is considerable evidence of their involvement in many malignancies, such as oesophageal and gastric. We hypothesised altered expressions of pri-miR-124-1 rs531564 and STAT3 rs1053023 polymorphisms in gastric cancer. Read More

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https://www.tandfonline.com/doi/full/10.1080/09674845.2018.1
Publisher Site
http://dx.doi.org/10.1080/09674845.2018.1492206DOI Listing
October 2018
4 Reads

IL-28B rs12979860 polymorphism affect the course of chronic hepatitis and the development of HCC in Egyptian patients with hepatitis C type 4.

Br J Biomed Sci 2018 Oct 21;75(4):157-162. Epub 2018 Aug 21.

b Department of Endemic Medicine and Hepatology, Faculty of Medicine , Cairo University , Cairo , Egypt.

Background: A single nucleotide polymorphism (SNP) in the interleukin 28B (IL28B) gene may alter the trajectory of hepatitis C virus (HCV) chronic infection. Several studies have sought to determine a link between IL28B rs12979860 SNP and the development of HCV-related hepatocellular carcinoma (HCC), but with variable results, and consensus is awaited. We hypothesised that IL28B rs12979860 SNP is linked to HCC in patients with HCV type 4. Read More

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http://dx.doi.org/10.1080/09674845.2018.1489599DOI Listing
October 2018
4 Reads

Impact of GSTM1, GSTT1 and GSTP1 genes polymorphisms on clinical toxicities and response to concomitant chemoradiotherapy in cervical cancer.

Br J Biomed Sci 2018 Oct 17;75(4):169-174. Epub 2018 Aug 17.

a Molecular and Human Genetics Laboratory, Department of Zoology , University of Lucknow , Lucknow , India.

Background: Certain forms of chemoradiotherapy generate toxic reactive oxygen species, which may be ameliorated by antioxidant enzymes such as glutathione S-transferase (GST). Genetic polymorphisms of GST may predict treatment outcomes and can be used as genetic marker to screen patients before treatment. We hypothesised an effect of GST polymorphisms on the response and toxicities produced by chemoradiation therapy. Read More

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http://dx.doi.org/10.1080/09674845.2018.1482734DOI Listing
October 2018
6 Reads

Genetic polymorphisms in KCNJ11 (E23K, rs5219) and SDF-1β (G801A, rs1801157) genes are associated with the risk of type 2 diabetes mellitus.

Br J Biomed Sci 2018 Jul 12;75(3):139-144. Epub 2018 Jun 12.

b Science and Technology , Amity Institute of Biotechnology, Amity University Uttar Pradesh , Lucknow , India.

Background Type 2 diabetes mellitus (T2DM) is a global major health problem resulting from interaction of environmental and genetic factors, examples of the latter being KCNJ11 (coding for part of the ATP-sensitive potassium channel) and SDF-1β (coding for chemokine CXCL12). Our case-control study was conducted to assess whether recessive, dominant or additive genotype model associations of KCNJ11 (E23K, rs5219) and SDF-1β (G801A, rs1801157) were more strongly linked to type 2 diabetes. Subjects & Methods Genetic polymorphism analysis was performed by polymerase chain reaction-restriction fragment length polymorphism. Read More

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http://dx.doi.org/10.1080/09674845.2018.1473939DOI Listing

The gamma-glutamyl transferase to platelet ratio and the FIB-4 score are noninvasive markers to determine the severity of liver fibrosis in chronic hepatitis B infection.

Br J Biomed Sci 2018 Jul 12;75(3):128-132. Epub 2018 Jun 12.

c Department of Laboratory Medicine , Yonsei University College of Medicine , Seoul , Korea.

Objective Noninvasive liver fibrosis evaluation is an important issue in chronic hepatitis B infection, and may be assessed using transient elastography (Fibroscan) or with blood markers. We compared the value of Fibroscan with that of a panel of routine serum markers. Materials and methods We recruited 278 chronic hepatitis B patients who underwent Fibroscan and HBV DNA testing. Read More

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http://dx.doi.org/10.1080/09674845.2018.1459147DOI Listing
July 2018
10 Reads

Clinical value of a diagnostic score for colon cancer based on serum CEA, CA19-9, cytokeratin-1 and mucin-1.

Br J Biomed Sci 2018 Jul 8;75(3):122-127. Epub 2018 May 8.

c Chemistry Department, Faculty of Science , Cairo University , Cairo , Egypt.

Background: Although established markers such as CEA and CA19-9 are important for diagnosing early stages of colon cancer, they are not ideal. Developing promising markers include cytokeratin 1 (CK1) and mucin-1 (MUC1), but the combined value of each of these markers is unclear. We therefore evaluated the value of a combined laboratory-based score of these four markers in the diagnosis of colon cancer. Read More

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http://dx.doi.org/10.1080/09674845.2018.1456309DOI Listing
July 2018
2 Reads

The role of rs267606943 polymorphism in the prolidase gene and plasma prolidase in polycystic ovary syndrome.

Br J Biomed Sci 2018 Jul 18;75(3):153-155. Epub 2018 Apr 18.

a Centre for Medical Biotechnology , Maharshi Dayanand University , Rohtak , India.

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http://dx.doi.org/10.1080/09674845.2018.1455489DOI Listing

Haematoxylin - the story of the blues.

Authors:
G E Orchard

Br J Biomed Sci 2018 Jul 18;75(3):149-152. Epub 2018 Apr 18.

a Viapath Analytics, Histopathology Department , St John's Institute of Dermatology, St. Thomas' Hospital , London , UK.

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http://dx.doi.org/10.1080/09674845.2018.1439430DOI Listing

Rapid detection and subtyping of human papillomaviruses in condyloma acuminatum using loop-mediated isothermal amplification with hydroxynaphthol blue dye.

Br J Biomed Sci 2018 Jul 14;75(3):110-115. Epub 2018 Mar 14.

a Department of Central Laboratory , Shanghai Tenth People's Hospital, Tongji University , Shanghai , China.

Objective Condyloma acuminatum (CA) is a common, viral, sexually transmitted disease worldwide. Human papillomavirus (HPV) genotyping has important clinical implications for the treatment of CA. We developed a loop-mediated isothermal amplification (LAMP) method for the detection of HPV. Read More

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https://www.tandfonline.com/doi/full/10.1080/09674845.2017.1
Publisher Site
http://dx.doi.org/10.1080/09674845.2017.1411864DOI Listing
July 2018
11 Reads

Effects of miR-27a, miR-196a2 and miR-146a polymorphisms on the risk of breast cancer.

Br J Biomed Sci 2018 Apr 9;75(2):76-81. Epub 2018 Mar 9.

e Cellular and Molecular Research Center, Faculty of Medicine , Guilan University of Medical Sciences , Rasht , Iran.

Background microRNAs (miRNAs) are potentially involved in many physiopathological processes, including regulation of cell growth, differentiation, apoptosis and cancer. Single nucleotide polymorphisms of the genes encoding miRNAs can alter their expression and may influence cancer risks. This case-control study explored the relationship between three microRNA polymorphisms (miR-27a, miR-196a2 and miR -146a) and breast cancer (BC). Read More

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http://dx.doi.org/10.1080/09674845.2017.1399572DOI Listing
April 2018
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The relationship of systemic markers of haemostasis with retinal blood vessel responses in cardiovascular disease and/or diabetes.

Br J Biomed Sci 2018 Jul 9;75(3):116-121. Epub 2018 Mar 9.

d University of Birmingham Institute for Cardiovascular Sciences, City Hospital , Birmingham , UK.

Background Hypercoagulability is a leading factor in diabetes and cardiovascular disease. Retinal vessel responses to flickering light are an important tool for assessing ocular function. We hypothesised a significant relationship between systemic markers of haemostasis and retinal vessel function. Read More

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http://dx.doi.org/10.1080/09674845.2017.1420130DOI Listing