161,397 results match your criteria British Accounting Review[Journal]


Our First Month of Delivering the Prostate Cancer Diagnostic Pathway within the Limitations of COVID-19 Using Local Anaesthetic Transperineal Biopsy.

BJU Int 2020 May 26. Epub 2020 May 26.

Department of Urology, Guy's at St Thomas' Hospitals, London, UK.

The COVID-19 pandemic is impacting all urological cancer services. On March 19 the British Association of Urological Surgeons (BAUS) provided pragmatic guidance for prostate cancer diagnostic services (Table 1).(1). Read More

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http://dx.doi.org/10.1111/bju.15120DOI Listing

Contribution of Immunoscore and Molecular Features to Survival Prediction in Stage III Colon Cancer.

JNCI Cancer Spectr 2020 Jun 5;4(3):pkaa023. Epub 2020 Apr 5.

Division of Oncology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.

Background: The American Joint Committee on Cancer staging and other prognostic tools fail to account for stage-independent variability in outcome. We developed a prognostic classifier adding Immunoscore to clinicopathological and molecular features in patients with stage III colon cancer.

Methods: Patient (n = 559) data from the FOLFOX arm of adjuvant trial NCCTG N0147 were used to construct Cox models for predicting disease-free survival (DFS). Read More

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http://dx.doi.org/10.1093/jncics/pkaa023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236783PMC

Course 2 - creating a specialty registrars procedure course.

Future Healthc J 2020 Feb;7(Suppl 1):s101

Queen Alexandra Hospital, Portsmouth, UK.

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http://dx.doi.org/10.7861/fhj.7.1.s101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241149PMC
February 2020

Selective Cyclized α-Melanocyte-Stimulating Hormone Derivative with Multiple -Methylations for Melanoma Imaging with Positron Emission Tomography.

ACS Omega 2020 May 7;5(19):10767-10773. Epub 2020 May 7.

Department of Molecular Oncology, BC Cancer, 675 W 10th Avenue, Vancouver, British Columbia V5Z 1L3, Canada.

In this study, we designed and evaluated a novel α-melanocyte-stimulating hormone derivative with four -methylations for melanocortin 1 receptor-targeted melanoma imaging with positron emission tomography (PET). The resulting peptide, DOTA-Pip-Nle-Cyclo[Asp--Me-His-d-Phe--Me-Arg--Me-Trp--Me-Lys]αMSH-NH (CCZ01099), showed high receptor selectivity, greatly improved stability, and rapid internalization. [Ga]Ga-CCZ01099 showed clear tumor visualization and excellent tumor-to-normal tissue contrast with PET imaging in a preclinical melanoma model. Read More

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http://dx.doi.org/10.1021/acsomega.0c00310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240809PMC

Splenectomy for Solitary Splenic Metastasis in Recurrent Papillary Thyroid Cancer. A Case Report and Literature Review.

Case Rep Oncol Med 2020 4;2020:2084847. Epub 2020 May 4.

Department of Surgical Oncology, American British Cowdray Medical Center, Mexico City, Mexico.

Thyroid cancer is the most common endocrine malignancy, presenting with 23 500 new cases per year in the United States. About 7-23% of the patients will present recurrent metastases disease during follow-up. The classic variant of papillary carcinoma is less aggressive compared to its other variants like diffuse sclerosing, tall cell or columnar cell, and insular variants, and the sites to which this metastasizes is already well identified. Read More

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http://dx.doi.org/10.1155/2020/2084847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7232720PMC

State-dependent foraging by caribou with different nutritional requirements.

J Mammal 2020 May 2;101(2):544-557. Epub 2020 Mar 2.

Natural Resources and Environmental Studies, University of Northern British Columbia, Prince George, British Columbia, Canada.

Foraging by animals is hypothesized to be state-dependent, that is, varying with physiological condition of individuals. State often is defined by energy reserves, but state also can reflect differences in nutritional requirements (e.g. Read More

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http://dx.doi.org/10.1093/jmammal/gyaa003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7236907PMC

Real-time PCR-based SARS-CoV-2 detection in Canadian laboratories.

J Clin Virol 2020 May 13;128:104433. Epub 2020 May 13.

National Microbiology Laboratory (NML), Public Health Agency of Canada (PHAC), Winnipeg, Manitoba, Canada.

With emergence of pandemic COVID-19, rapid and accurate diagnostic testing is essential. This study compared laboratory-developed tests (LDTs) used for the detection of SARS-CoV-2 in Canadian hospital and public health laboratories, and some commercially available real-time RT-PCR assays. Overall, analytical sensitivities were equivalent between LDTs and most commercially available methods. Read More

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http://dx.doi.org/10.1016/j.jcv.2020.104433DOI Listing

Bioactive compounds with possible inhibitory activity of Angiotensin-Converting Enzyme-II; a gate to manage and prevent COVID-19.

Med Hypotheses 2020 May 16;143:109841. Epub 2020 May 16.

Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Epilepsy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

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http://dx.doi.org/10.1016/j.mehy.2020.109841DOI Listing

Genetic variants drive altered epigenetic regulation of endotoxin response in BTBR macrophages.

Brain Behav Immun 2020 May 23. Epub 2020 May 23.

Department of Medical Microbiology and Immunology, MIND Institute, Genome Center, University of California, Davis, CA USA 95616, USA.

The BTBR TItpr3/J (BTBR) mouse has been used as a complex genetic model of Autism Spectrum Disorders (ASD). While the specific mechanisms underlying BTBR behavioral phenotypes are poorly understood, prior studies have implicated profound differences in innate immune system control of pro-inflammatory cytokines. Innate immune activation and elevated pro-inflammatory cytokines are also detected in blood of children with ASD. Read More

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http://dx.doi.org/10.1016/j.bbi.2020.05.058DOI Listing

Mechanical Ventilation Duration, Brainstem Development, and Neurodevelopment in Children Born Preterm: A Prospective Cohort Study.

J Pediatr 2020 May 23. Epub 2020 May 23.

Department of Pediatrics (Neurology), University of Toronto and the Hospital for Sick Children, Toronto, Canada. Electronic address:

Objectives: To determine, In children born preterm, the association of mechanical ventilation duration with brainstem development, white matter maturation, and neurodevelopmental outcomes at preschool age.

Study Design: This prospective cohort study included 144 neonates born at <30 weeks' gestation (75 males, mean gestational age 27.1 weeks, SD 1. Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.05.039DOI Listing

The Need for Patient Voices in Food Allergy Research.

Ann Allergy Asthma Immunol 2020 May 23. Epub 2020 May 23.

Department of Pediatrics and Child Health, The University of Manitoba, Canada; George and Fay Yee Centre for Healthcare Innovation, Winnipeg, Canada; The Children's Health Research Institute of Manitoba, Winnipeg, Canada; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden; Food and Human Nutritional Sciences, The University of Manitoba, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.anai.2020.05.017DOI Listing

Endothelin signaling promotes melanoma tumorigenesis driven by constitutively active GNAQ.

Pigment Cell Melanoma Res 2020 May 26. Epub 2020 May 26.

Department of Medical Genetics, University of British Columbia, Life Sciences Institute, 2350 Health Sciences Mall, Vancouver B.C., V6T 1Z3, Vancouver, Canada.

The G protein coupled receptor, Endothelin receptor B (EDNRB), is an important regulator of melanocyte survival and proliferation. It acts by stimulating downstream heterotrimeric G proteins, such as Gα and Gα . Constitutively active, oncogenic versions of Gα and Gα drive melanomagenesis, but the role of Ednrb in the context of these mutant G proteins has not been previously examined. Read More

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http://dx.doi.org/10.1111/pcmr.12900DOI Listing

Proteomics of intracellular freezing survival.

PLoS One 2020 26;15(5):e0233048. Epub 2020 May 26.

Biochemistry Department, Carleton University, Ottawa, Canada.

Panagrolaimus sp. DAW1, a nematode cultured from the Antarctic, has the extraordinary physiological ability to survive total intracellular freezing throughout all of its compartments. While a few other organisms, all nematodes, have subsequently also been found to survive freezing in this manner, P. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233048PLOS

Irgm1-deficiency leads to myeloid dysfunction in colon lamina propria and susceptibility to the intestinal pathogen Citrobacter rodentium.

PLoS Pathog 2020 May 26;16(5):e1008553. Epub 2020 May 26.

Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina, United States of America.

IRGM and its mouse orthologue Irgm1 are dynamin-like proteins that regulate vesicular remodeling, intracellular microbial killing, and pathogen immunity. IRGM dysfunction is linked to inflammatory bowel disease (IBD), and while it is thought that defective intracellular killing of microbes underscores IBD susceptibility, studies have yet to address how IRGM/Irgm1 regulates immunity to microbes relevant to intestinal inflammation. Here we find that loss of Irgm1 confers marked susceptibility to Citrobacter rodentium, a noninvasive intestinal pathogen that models inflammatory responses to intestinal bacteria. Read More

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http://dx.doi.org/10.1371/journal.ppat.1008553DOI Listing

COVID-19: Safe Guidelines for Breast Imaging During the Pandemic.

Can Assoc Radiol J 2020 May 26:846537120928864. Epub 2020 May 26.

Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada.

During the COVID-19 pandemic, breast imaging must be performed using safe practices. Balancing the need to avoid delays in the diagnosis of breast cancer while avoiding infection requires careful attention to personal protective equipment and physical distancing and vigilance to maintain these practices. The Canadian Society of Breast Imaging/Canadian Association of Radiologists guideline for breast imaging during COVID-19 is provided based on priority according to risk of breast cancer and impact of delaying treatment. Read More

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http://dx.doi.org/10.1177/0846537120928864DOI Listing

P-glycoprotein and multidrug resistance-associated protein-1 expression in acute myeloid leukemia: Biological and prognosis implications.

Int J Lab Hematol 2020 May 26. Epub 2020 May 26.

Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte (DACT/UFRN), Natal, Brazil.

Background: Despite the advances in the cure rate for acute myeloid leukemia (AML), a considerable number of patients die from the disease due to the occurrence of multidrug resistance (MDR). Overexpression of the transporter proteins, such as P-glycoprotein (Pgp) and multidrug resistance-associated protein (MRP), confers resistance to the treatment of these leukemias.

Methods: To analyze the expression of the Pgp and MRP1 in patients with AML and determine their correlation between expression and demographic, clinical, and laboratorial variables, bone marrow and peripheral blood samples from 346 patients with a diagnosis of AML were assessed for the expression of Pgp and MRP1 by flow cytometry. Read More

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http://dx.doi.org/10.1111/ijlh.13241DOI Listing

Functional connectome contractions in temporal lobe epilepsy: Microstructural underpinnings and predictors of surgical outcome.

Epilepsia 2020 May 26. Epub 2020 May 26.

Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.

Objective: Temporal lobe epilepsy (TLE) is the most common drug-resistant epilepsy in adults. Although it is commonly related to hippocampal pathology, increasing evidence suggests structural changes beyond the mesiotemporal lobe. Functional anomalies and their link to underlying structural alterations, however, remain incompletely understood. Read More

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http://dx.doi.org/10.1111/epi.16540DOI Listing

Association between Household Livestock Ownership and Childhood Stunting in Bangladesh - A Spatial Analysis.

J Trop Pediatr 2020 Jun;66(3):248-256

Biomedical Research Foundation, Dhaka-1230, Bangladesh.

Livestock is an integrated part of agriculture, yet the relationship between household livestock ownership and child nutrition is a significant knowledge gap. The present study aimed to assess the association between household livestock ownership and childhood stunting and to explore the geospatial variations at district level in Bangladesh. A complete data of 19 295 children aged below 5 years were extracted from the latest Bangladesh Multiple Indicator Cluster Survey 2012-13. Read More

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http://dx.doi.org/10.1093/tropej/fmz061DOI Listing

Isolation of and characterisation of potentially pathogenic Vibrio species in a temperate, higher latitude hotspot.

Environ Microbiol Rep 2020 May 25. Epub 2020 May 25.

Centre for Environment Fisheries and Aquaculture Science, Weymouth, Dorset, UK.

The recent emergence of Vibrio infections at high latitudes represents a clear human health risk attributable to climate change. Here, we investigate the population dynamics of three Vibrio species: Vibrio parahaemolyticus, Vibrio vulnificus and Vibrio cholerae within a British coastal estuarine site, with contrasting salinity and temperature regimes during an intense heatwave event. Water samples were collected weekly through the summer of 2018 and 2019 and filtered using membrane filtration and subsequently grown on selective media. Read More

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http://dx.doi.org/10.1111/1758-2229.12858DOI Listing

Effect of alcohol prohibition on liver cirrhosis mortality rates in Canada from 1901 to 1956: A time-series analysis.

Drug Alcohol Rev 2020 May 25. Epub 2020 May 25.

Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Canada.

Introduction And Aims: The extent to which alcohol consumption in Canada was affected by alcohol prohibition in the early 20th century remains unclear. Since there is a dearth of data on consumption during this time, we estimated the effect of alcohol prohibition on alcohol consumption, as measured by changes in liver cirrhosis mortality rates in Canada.

Design And Methods: Annual liver cirrhosis mortality data were obtained for 1901 to 1956 for the provinces of Alberta, British Columbia, Manitoba, New Brunswick, Nova Scotia, Ontario and Saskatchewan. Read More

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http://dx.doi.org/10.1111/dar.13089DOI Listing

Codependency between plant and arbuscular mycorrhizal fungal communities: what is the evidence?

New Phytol 2020 May 25. Epub 2020 May 25.

University of British Columbia Okanagan, Biology, Kelowna, BC, V1V 1V7, Canada.

That arbuscular mycorrhizal (AM) fungi covary with plant communities is clear, and many papers report non-random associations between symbiotic partners. However, these studies do not test the causal relationship, or "codependency", whereby the composition of one guild affects the composition of the other. Here we outline underlying requirements for codependency, compare important drivers for both plant and AM fungal communities, and assess how host preference-a pre-requisite for codependency-changes across spatiotemporal scales and taxonomic resolution for both plants and AM fungi. Read More

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http://dx.doi.org/10.1111/nph.16676DOI Listing

Characterization of Schistosoma mansoni Dihydrofolate Reductase (DHFR).

Methods Mol Biol 2020 ;2151:159-172

Physics Institute of São Carlos, University of São Paulo, São Paulo, SP, Brazil.

Dihydrofolate reductase (DHFR) is an essential enzyme for nucleotide metabolism used to obtain energy and structural nucleic acids. Schistosoma mansoni has all the pathways for pyrimidine biosynthesis, which include the thymidylate cycle and, consequentially, the DHFR enzyme. Here, we describe the characterization of Schistosoma mansoni DHFR (SmDHFR) using isothermal titration calorimetry for the enzymatic activity and thermodynamic determination, also the folate analogs inhibition. Read More

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http://dx.doi.org/10.1007/978-1-0716-0635-3_13DOI Listing
January 2020

Neurophysiological monitoring of spinal cord function during spinal deformity surgery: 2020 SRS neuromonitoring information statement.

Spine Deform 2020 May 25. Epub 2020 May 25.

Radboud University Medical Center, Postbus 9101, 6500 HB, Nijmegen, The Netherlands.

The Scoliosis Research Society has developed an updated information statement on intraoperative neurophysiological monitoring of spinal cord function during spinal deformity surgery. The statement reviews the risks of spinal cord compromise associated with spinal deformity surgery; the statement then discusses the various modalities that are available to monitor the spinal cord, including somatosensory-evoked potentials, motor-evoked potentials, and electromyographic (EMG) options. Anesthesia considerations, the importance of a thoughtful team approach to successful monitoring, and the utility of checklists are also discussed. Read More

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http://dx.doi.org/10.1007/s43390-020-00140-2DOI Listing

The Effect of Compression Applied Through Constrained Lateral Eccentricity on the Failure Mechanics and Flexibility of the Human Cervical Spine.

J Biomech Eng 2020 May 26. Epub 2020 May 26.

Orthopaedic and Injury Biomechanics Group, Departments of Mechanical Engineering and Orthopaedics, University of British Columbia, International Collaboration on Repair Discoveries (ICORD), University of British Columbia, School of Biomedical Engineering, University of British Columbia.

In contrast to sagittal plane spine biomechanics, little is known about the response of the cervical spine to axial compression with lateral eccentricity of the applied force. This study evaluated the effect of lateral eccentricity on kinetics, kinematics, canal occlusion, injuries and flexibility of the cervical spine in translationally-constrained axial impacts. Eighteen functional spinal units were subjected to flexibility tests before and after an impact. Read More

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http://dx.doi.org/10.1115/1.4047342DOI Listing

Modeling the Putative Ancient Distribution of Aedes togoi (Diptera: Culicidae).

J Insect Sci 2020 May;20(3)

Department of Zoology, University of British Columbia, Vancouver, BC, Canada.

The coastal rock pool mosquito, Aedes (Tanakius) togoi (Theobald) (Diptera: Culicidae), is found in coastal east Asia in climates ranging from subtropical to subarctic. However, a disjunct population in the Pacific Northwest of North America has an ambiguous heritage. Two potential models explain the presence of Ae. Read More

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http://dx.doi.org/10.1093/jisesa/ieaa035DOI Listing

Cardiovascular imaging to guide primary prevention.

Heart 2020 May 25. Epub 2020 May 25.

British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK

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http://dx.doi.org/10.1136/heartjnl-2019-316217DOI Listing

Is withdrawing treatment really more problematic than withholding treatment?

J Med Ethics 2020 May 25. Epub 2020 May 25.

Murdoch Childrens Research Institute, Parkville, Victoria, Australia.

There is a concern that as a result of COVID-19 there will be a shortage of ventilators for patients requiring respiratory support. This concern has resulted in significant debate about whether it is appropriate to withdraw ventilation from one patient in order to provide it to another patient who may benefit more. The current advice available to doctors appears to be inconsistent, with some suggesting withdrawal of treatment is more serious than withholding, while others suggest that this distinction should not be made. Read More

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http://dx.doi.org/10.1136/medethics-2020-106330DOI Listing

Activating AKT1 and PIK3CA Mutations in Metastatic Castration-Resistant Prostate Cancer.

Eur Urol 2020 May 22. Epub 2020 May 22.

Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada. Electronic address:

Background: Activating mutations in AKT1 and PIK3CA are undercharacterised in metastatic castration-resistant prostate cancer (mCRPC), but are linked to activation of phosphatidylinositol 3-kinase (PI3K) signalling and sensitivity to pathway inhibitors in other cancers.

Objective: To determine the prevalence, genomic context, and clinical associations of AKT1/PIK3CA activating mutations in mCRPC.

Design, Setting, And Participants: We analysed targeted cell-free DNA (cfDNA) sequencing data from 599 metastatic prostate cancer patients with circulating tumour DNA (ctDNA) content above 2%. Read More

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http://dx.doi.org/10.1016/j.eururo.2020.04.058DOI Listing

Deregulated Regulators: Disease-Causing cis Variants in Transcription Factor Genes.

Trends Genet 2020 May 22. Epub 2020 May 22.

Centre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, The University of British Columbia, Vancouver, BC, Canada.. Electronic address:

Whole-genome sequencing is accelerating identification of noncoding variants that disrupt gene expression, although reports of such regulatory variants implicated in disease remain rare. A notable subset of described variants affect transcription factor (TF) genes and other master regulators in cis through dosage effects. From the literature, we compiled 46 regulatory variants linked to 40 TF genes implicated in rare diseases. Read More

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http://dx.doi.org/10.1016/j.tig.2020.04.006DOI Listing

DECAES - DEcomposition and Component Analysis of Exponential Signals.

Z Med Phys 2020 May 22. Epub 2020 May 22.

Department of Physics and Astronomy, University of British Columbia, 6224 Agricultural Road, V6T 1Z1 Vancouver, BC, Canada; UBC MRI Research Centre, 2221 Wesbrook Mall, V6T 2B5 Vancouver, BC, Canada; Department of Radiology, University of British Columbia, 2775 Laurel Street, V5Z 1M9 Vancouver, BC, Canada; Department of Pediatrics, Faculty of Medicine, University of British Columbia, 4480 Oak Street, BC Children's Hospital, V6H 3V4 Vancouver, BC, Canada.

Combinations of multiple exponentially decaying signals are found across many disciplines of science. Decomposition of these multi-exponential signals into their individual components provides insight into the various contributors to the signal. Magnetic resonance images, for instance, can be acquired with multiple gradient or spin echoes to provide voxel by voxel multi-exponential T2* or T2 decays, respectively. Read More

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http://dx.doi.org/10.1016/j.zemedi.2020.04.001DOI Listing

Perception of healthcare access and utility of telehealth among Parkinson disease patients.

Can J Neurol Sci 2020 May 26:1-14. Epub 2020 May 26.

Southern Medical Program, University of British Columbia Okanagan, Kelowna, BC, Canada.

Regional patient and physician density patterns pose problems to accessing care for people with Parkinson disease, though telehealth may improve access. We surveyed and conducted a focus group for people with Parkinson disease in Interior BC regarding barriers to neurological care. Eighteen individuals completed the survey and seven parties joined the focus group. Read More

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http://dx.doi.org/10.1017/cjn.2020.99DOI Listing

Access to allied health care services in Canadian interdisciplinary complex nerve injury programs.

Can J Neurol Sci 2020 May 26:1-12. Epub 2020 May 26.

British Columbia Centre for Complex Nerve Injury, Vancouver, British Columbia, Canada.

Nerve transfer surgery (NT) for patients with nerve and spinal cord injuries can result in dramatic functional improvements. As a result, interdisciplinary complex nerve injury programs (CNIPs) have been established in many Canadian centres, providing electrodiagnostic and surgical consultations in a single encounter. We sought to determine which allied health care services are included in Canadian CNIPs, at the 3rd Annual Canadian Peripheral Nerve Symposium. Read More

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http://dx.doi.org/10.1017/cjn.2020.98DOI Listing

A review of reviews on principles, strategies, outcomes and impacts of research partnerships approaches: a first step in synthesising the research partnership literature.

Health Res Policy Syst 2020 May 25;18(1):51. Epub 2020 May 25.

School of Health & Exercise Sciences, University of British Columbia, Kelowna, Canada.

Background: Conducting research in partnership with stakeholders (e.g. policy-makers, practitioners, organisations, patients) is a promising and popular approach to improving the implementation of research findings in policy and practice. Read More

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http://dx.doi.org/10.1186/s12961-020-0544-9DOI Listing

Personalized and graph genomes reveal missing signal in epigenomic data.

Genome Biol 2020 May 25;21(1):124. Epub 2020 May 25.

Human Genetics, McGill University, Montreal, QC, Canada.

Background: Epigenomic studies that use next generation sequencing experiments typically rely on the alignment of reads to a reference sequence. However, because of genetic diversity and the diploid nature of the human genome, we hypothesize that using a generic reference could lead to incorrectly mapped reads and bias downstream results.

Results: We show that accounting for genetic variation using a modified reference genome or a de novo assembled genome can alter histone H3K4me1 and H3K27ac ChIP-seq peak calls either by creating new personal peaks or by the loss of reference peaks. Read More

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http://dx.doi.org/10.1186/s13059-020-02038-8DOI Listing

Results from a 2018 cross-sectional survey in Tokyo, Osaka and Sendai to assess tobacco and nicotine product usage after the introduction of heated tobacco products (HTPs) in Japan.

Harm Reduct J 2020 May 26;17(1):32. Epub 2020 May 26.

Research & Development, British American Tobacco, Southampton, SO15 8TL, UK.

Background: For novel tobacco products that potentially reduce the risk of tobacco harm, post-market surveillance is important to observe population usage and behaviours associated with everyday use. This pilot study was performed to examine the use of tobacco products in three Japanese urban regions.

Methods: This study was a cross-sectional epidemiological survey administered in Sendai, Tokyo and Osaka, Japan, from May 19th to June 25th, 2018. Read More

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http://dx.doi.org/10.1186/s12954-020-00374-3DOI Listing

The Peacock study: feasibility of the dynamic characterisation of the paediatric hypothalamic-pituitary-adrenal function during and after cardiac surgery.

BMC Cardiovasc Disord 2020 May 25;20(1):245. Epub 2020 May 25.

Department of Cardiac Anaesthesia, Bristol Heart Institute, Bristol, UK.

Background: Cortisol is the main stress hormone mobilised during surgery to establish homeostasis. Our current understanding of the hypothalamic-pituitary-adrenal axis physiology in children undergoing cardiopulmonary bypass is very limited due to: (1) very few cortisol time point measurements over long periods (2) difficulties of sampling in low weight babies and (3) the concomitant use of glucocorticoids at anaesthesia induction. This lack of understanding is reflected in a lack of consensus on the utility of glucocorticoids perioperatively in cardiac surgery with the use of cardiopulmonary bypass. Read More

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http://dx.doi.org/10.1186/s12872-020-01516-yDOI Listing

Prefrailty in Older Adults: A Concept Analysis.

Int J Nurs Stud 2020 May 8;108:103618. Epub 2020 May 8.

Departments of Medicine and Community Health Sciences, University of Calgary, 11th Floor South Tower, Room 1104, 1403-29 Street NW, Calgary, Alberta, Canada T2N 2T9. Electronic address:

Background: The concept of prefrailty lacks clarity. Often, prefrailty is defined in relation to frailty and less often as a distinct concept. Theoretical evidence for prefrailty is minimal unlike frailty, which has been examined for decades although consensus about how to measure frailty has not been achieved. Read More

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http://dx.doi.org/10.1016/j.ijnurstu.2020.103618DOI Listing

Atypical clinical presentation of Ebola virus disease in pregnancy: Implications for clinical and public health management.

Int J Infect Dis 2020 May 22. Epub 2020 May 22.

Ministry of Health and Sanitation, Youyi Building, Freetown, Sierra Leone.

Background: Between December 2013 and June 2016, West Africa experienced the largest Ebola virus disease (EVD) outbreak in history. Understanding EVD in pregnancy is important for EVD clinical screening and infection prevention and control.

Methods: We conducted a review of medical records and EVD investigation reports from three districts in Sierra Leone. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.05.064DOI Listing

A Phased Approach to Resuming Suspended Allergy/Immunology Clinical Services.

J Allergy Clin Immunol Pract 2020 May 22. Epub 2020 May 22.

Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado. Electronic address:

In early 2020, the first US and Canadian cases of the novel SARS-CoV-2 infection were detected. In the ensuing months, there has been rapid spread of the infection. In March 2020, in response to the virus, state/provincial and local governments instituted shelter-in-place orders, and non-essential ambulatory care was significantly curtailed, including allergy/immunology services. Read More

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http://dx.doi.org/10.1016/j.jaip.2020.05.012DOI Listing

Regulation of CD71TER119 erythroid progenitor cells by CD45.

Exp Hematol 2020 May 22. Epub 2020 May 22.

Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada. Electronic address:

Red blood cells are generated daily to replenish dying cells and maintain erythrocyte homeostasis. Erythropoiesis is driven by erythropoietin and supported by specialized red pulp macrophages that facilitate enucleation. Here, we show that the leukocyte-specific tyrosine phosphatase, CD45 is down regulated in late erythroid development, yet it regulates the CD71TER119 progenitor pool, which includes the Pro E, Ery A and Ery B populations. Read More

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http://dx.doi.org/10.1016/j.exphem.2020.05.005DOI Listing

Flood Footprint Assessment: A Multiregional Case of 2009 Central European Floods.

Risk Anal 2020 May 25. Epub 2020 May 25.

Department of Earth System Sciences, Tsinghua University, Beijing, China.

Hydrometeorological phenomena have increased in intensity and frequency in last decades, with Europe as one of the most affected areas. This accounts for considerable economic losses in the region. Regional adaptation strategies for costs minimization require a comprehensive assessment of the disasters' economic impacts at a multiple-region scale. Read More

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http://dx.doi.org/10.1111/risa.13497DOI Listing

Global real-world evidence of sofosbuvir/velpatasvir as simple, effective HCV treatment: analysis of 5552 patients from 12 cohorts.

Liver Int 2020 May 25. Epub 2020 May 25.

C.H.U. Pontevedra and IIS Galicia Sur, Department of Gastroenterology and Hepatology, Galicia Sur, Spain.

Background And Aims: Achieving sustained virological response (SVR; cure) in hepatitis C patients using a simple regimen is key to making elimination by 2030 possible. In the largest real-world analysis to date, the effectiveness of pangenotypic, panfibrotic, single-tablet, sofosbuvir/velpatasvir (SOF/VEL) once-daily for 12 weeks was assessed in 12 clinical real-world cohorts from various geographical areas, settings and treatment practices. Factors affecting risk of not achieving SVR were assessed. Read More

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http://dx.doi.org/10.1111/liv.14537DOI Listing

Complete mitochondrial genome of a gymnosperm, Sitka spruce (Picea sitchensis), indicates a complex physical structure.

Genome Biol Evol 2020 May 25. Epub 2020 May 25.

Genome Sciences Centre, BC Cancer, Vancouver, BC V5Z 4S6, Canada.

Plant mitochondrial genomes vary widely in size. Although many plant mitochondrial genomes have been sequenced and assembled, the vast majority are of angiosperms, and few are of gymnosperms. Most plant mitochondrial genomes are smaller than a megabase, with a few notable exceptions. Read More

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http://dx.doi.org/10.1093/gbe/evaa108DOI Listing

Considerations in Treating Severe Acne with Isotretinoin in Transgender Men.

J Cutan Med Surg 2020 May 25:1203475420930224. Epub 2020 May 25.

233826 Department of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1177/1203475420930224DOI Listing

Contextual performance of diagnostics for fetal surveillance.

BJOG 2020 May 25. Epub 2020 May 25.

Department of Obstetrics and Gynaecology, Children's and Women's Hospital and Health Centre of British Columbia, and the University of British Columbia, Vancouver, Canada.

Identification of women and fetuses at high risk for adverse perinatal outcomes is a central preoccupation in prenatal care. In recent years, the sonographically derived cerebroplacental ratio (CPR) has gained popularity for its ability to identify compromised fetuses among pregnancies with suspected growth restriction or placental disease. Although numerous studies and systematic reviews have examined the predictive performance of the CPR, there were many limitations. Read More

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http://dx.doi.org/10.1111/1471-0528.16334DOI Listing

"I Can Understand Where They're Coming From": How Clinicians' Disability Experiences Shape Their Interaction With Clients.

Qual Health Res 2020 May 25:1049732320922193. Epub 2020 May 25.

The University of British Columbia, Vancouver, British Columbia, Canada.

Students and clinicians with disabilities are underrepresented in the academic health programs and professional clinical settings. Disability studies foregrounds the unique ways of knowing and being that clinicians with disabilities can offer. Based on a larger grounded theory study of the experiences of students and clinicians with disabilities, this article examines the role that clinicians' abilities to draw on their personal experiences of living with a disability have on their interactions with clients. Read More

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http://dx.doi.org/10.1177/1049732320922193DOI Listing