20,660 results match your criteria Britain And The World[Journal]


Current Insights into the Potential Misuse of Platelet-based Applications for Doping in Sports.

Int J Sports Med 2019 Apr 23. Epub 2019 Apr 23.

Hull York Medical School, Centre for Atherothrombotic and Metabolic Disease, Hull, United Kingdom of Great Britain and Northern Ireland.

Platelet-based applications are currently used for the delivery of growth factors and other biomolecules as autologous biomaterials in regenerative medicine and cosmetic therapies. Many studies have revealed that platelet-based applications such as platelet-rich plasma and platelet releasate exhibit beneficial biological effects after a sports injury or trauma when administered locally by intramuscular injections. At present, treatment of the public, patients and athletes with platelet-based applications is permitted and regulated by the Food and Drug Administration and the World Anti-Doping Agency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-0884-0734DOI Listing

Antenatal dexamethasone treatment transiently alters diastolic function in the mouse fetal heart.

J Endocrinol 2019 Apr 1. Epub 2019 Apr 1.

K Chapman, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, United Kingdom of Great Britain and Northern Ireland.

Endogenous glucocorticoid action is important in the structural and functional maturation of the fetal heart. In fetal mice, although glucocorticoid concentrations are extremely low before E14.5, glucocorticoid receptor (GR) is expressed in the heart from E10. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/JOE-18-0666DOI Listing

Moth responses to sympathetic hedgerow management in temperate farmland.

Agric Ecosyst Environ 2019 Feb;270-271:55-64

University of Bristol, School of Biological Sciences, Life Sciences Building, 24 Tyndall Avenue, BS8 1TQ, Bristol, United Kingdom.

Hedgerows provide valuable habitats and corridors for many species in farmland, yet a lack of appropriate management may threaten their benefits to biodiversity. Although agri-environment scheme (AES) prescriptions on hedgerow management have the potential to reverse the detrimental effect of over-trimming on wildlife, their effectiveness has rarely been addressed. The aims of the study were to (i) assess moth responses to trimming regimes; and (ii) investigate the influence of the surrounding landscape on moth assemblages. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.agee.2018.10.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472680PMC
February 2019

HIVR4P 2018: From Research to Impact.

AIDS Res Hum Retroviruses 2019 Apr 22. Epub 2019 Apr 22.

International AIDS Society, 503988, Geneva, Switzerland ;

The HIV Research for Prevention (HIVR4P) conference is dedicated to advancing HIV prevention research, responding to a growing consensus that effective and durable prevention will require a combination of approaches as well as unprecedented collaboration among scientists, practitioners and community workers from different fields and geographic areas. The conference theme in 2018, "From Research to Impact", acknowledged an increasing focus on translation of promising research findings into practical, accessible and affordable HIV prevention options for those who need them worldwide. HIVR4P 2018 was held in Madrid, Spain, on 21-25 October, with over 1,400 participants from 52 countries around the globe, representing all aspects of HIV prevention research and implementation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/AID.2019.0074DOI Listing

Development of parental competence scale in parents of children with autism.

J Pediatr Nurs 2019 Apr 18. Epub 2019 Apr 18.

School of Health Nursing and Midwifery, University of the West of Scotland, Paisley, Scotland, United Kingdom of Great Britain and Northern Ireland.

Purpose: The purpose of this study is to develop and psychometrically of parental competence scale in parents of children with autism.

Design & Methods: This mixed-methods design with a sequential exploratory approach was conducted in May 2017 until June 2018 in the south of Iran. In the first phase, a conventional content analysis method was performed with the participation of 16 parents of children with autism. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S08825963183055
Publisher Site
http://dx.doi.org/10.1016/j.pedn.2019.04.006DOI Listing
April 2019
1 Read

Obesity and bariatric intervention in patients with chronic renal disease.

J Int Med Res 2019 Apr 21:300060519843755. Epub 2019 Apr 21.

1 Renal and Transplant Directorate, Hammersmith Hospital, Imperial College NHS Trust, London, United Kingdom of Great Britain and Northern Ireland.

Obesity is associated with chronic metabolic conditions that directly and indirectly cause kidney parenchymal damage. A review of the literature was conducted to explore existing evidence of the relationship between obesity and chronic kidney disease as well as the role of bariatric surgery in improving access to kidney transplantation for patients with a high body mass index. The review showed no definitive evidence to support the use of a transplant eligibility cut-off parameter based solely on the body mass index. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0300060519843755DOI Listing

ECG interpretation skill acquisition: A review of learning, teaching and assessment.

J Electrocardiol 2019 Apr 12. Epub 2019 Apr 12.

School of Nursing, Ulster University, Shore Road, Jordanstown Campus, BT37 0QB, United Kingdom of Great Britain and Northern Ireland; Institute of Nursing and Health Research, Ulster University, Shore Road, Jordanstown Campus, BT37 0QB, United Kingdom of Great Britain and Northern Ireland.

The recording of 12 lead electrocardiograms (ECG) is one of the most useful and commonly performed medical procedures. ECGs are used in diagnosis, risk-stratification management decision-making, and assessment in response to therapy. The correct interpretation of 12 lead ECG recordings is complex and clinically challenging with misinterpretation having the potential to result in poor outcomes or even patient fatality. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00220736183064
Publisher Site
http://dx.doi.org/10.1016/j.jelectrocard.2019.03.010DOI Listing
April 2019
1 Read

Recognising, managing and supporting dyslexia beyond registration. The lived experiences of qualified nurses and nurse academics.

Nurse Educ Pract 2019 Jan 25. Epub 2019 Jan 25.

Department of Nursing, Manchester Metropolitan University, Birley Building, Birley Fields Campus, 53 Bonsall Street, Manchester, M15 6GX, UK. Electronic address:

While there is a growing body of research on the effects of dyslexia on student nurses, this is not the case for registered nurses. The main aim of the study was to identify how dyslexia might affect registered nurses' engagement in lifelong learning and how lecturers can support them. A narrative lifecourse approach was taken to explore the experiences of 14 registered nurses with dyslexia from across Great Britain and nine lecturers from England and Scotland. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.nepr.2019.01.005DOI Listing
January 2019
3 Reads

A comprehensive assessment of stream fragmentation in Great Britain.

Sci Total Environ 2019 Apr 10;673:756-762. Epub 2019 Apr 10.

Department of Biosciences, College of Science, Swansea University, Swansea SA2 8PP, UK.

Artificial barriers are one of the main threats to river ecosystems, resulting in habitat fragmentation and loss of connectivity. Yet, the abundance and distribution of most artificial barriers, excluding high-head dams, is poorly documented. We provide a comprehensive assessment of the distribution and typology of artificial barriers in Great Britain, and estimate for the first time the extent of river fragmentation. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S00489697193165
Publisher Site
http://dx.doi.org/10.1016/j.scitotenv.2019.04.125DOI Listing
April 2019
1 Read

Contraception after pregnancy.

Acta Obstet Gynecol Scand 2019 Apr 18. Epub 2019 Apr 18.

University of Milan, Milano, Lombardia, Italy.

Whatever the outcome, pregnancy provides the opportunity to offer effective contraception to couples motivated to avoid another pregnancy. This narrative review summarises the evidence for health providers, drawing attention to current guidelines, on which contraceptive methods can be used, and when they should be started after pregnancy, whatever its outcome. Fertility returns within one month of the end of pregnancy unless breastfeeding occurs. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/aogs.13627
Publisher Site
http://dx.doi.org/10.1111/aogs.13627DOI Listing
April 2019
1 Read

Effect of ten-valent pneumococcal conjugate vaccine on invasive pneumococcal disease and nasopharyngeal carriage in Kenya: a longitudinal surveillance study.

Lancet 2019 Apr 15. Epub 2019 Apr 15.

Epidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine-Coast, Kilifi, Kenya; Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK; Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK; INDEPTH Network, Accra, Ghana.

Background: Ten-valent pneumococcal conjugate vaccine (PCV10), delivered at 6, 10, and 14 weeks of age was introduced in Kenya in January, 2011, accompanied by a catch-up campaign in Kilifi County for children aged younger than 5 years. Coverage with at least two PCV10 doses in children aged 2-11 months was 80% in 2011 and 84% in 2016; coverage with at least one dose in children aged 12-59 months was 66% in 2011 and 87% in 2016. We aimed to assess PCV10 effect against nasopharyngeal carriage and invasive pneumococcal disease (IPD) in children and adults in Kilifi County. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S0140-6736(18)33005-8DOI Listing

Surgical termination of pregnancy for fetal anomaly: what role can an independent abortion service provider play?

J Obstet Gynaecol 2019 Apr 19:1-6. Epub 2019 Apr 19.

c British Pregnancy Advisory Service , Stratford Upon Avon , UK.

Most hospitals in Great Britain only offer a medical termination of pregnancy for a fetal anomaly (TOPFA) in the second trimester. We describe the safety and acceptability of a surgical TOPFA service delivered by an independent-sector abortion provider. Non-identifiable data for women undergoing TOPFA at British Pregnancy Advisory Service from 1 January 2015 to 31 March 2016 was extracted from existing databases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/01443615.2019.1568973DOI Listing

Fatal phaeohyphomycosis due to Exophiala sp. infection in a free-living common toad Bufo bufo.

Dis Aquat Organ 2019 Feb;133(1):19-24

Institute of Zoology, Zoological Society of London, Regent's Park, London NW1 4RY, UK.

A wild adult female common toad Bufo bufo found dead in Scotland in September 2016 was observed to have hepatomegaly, a large soft tissue mass in the coelomic cavity (2.7 g, 3.5 × 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3354/dao03341DOI Listing
February 2019

The effect of risk communication on periodontal treatment outcomes: A randomized controlled trial.

J Periodontol 2019 Apr 17. Epub 2019 Apr 17.

Dental Institute, King's College London, London, United Kingdom of Great Britain and Northern Ireland.

Background: This study determines the effects of a routine assessment (Treatment as Usual, TAU) versus a risk communication intervention (Risk) versus a Goal-Setting, Planning and Self-Monitoring (GPS) intervention on periodontal disease patients' clinical and psychological outcomes.

Methods: In a three-arm randomized controlled trial (RCT; registration: ISRCTN59696243) adults (N = 97) judged to have moderate oral hygiene attended a primary dental care setting for a standard consultation. Intervention participants received an individualized calculation of their periodontal disease risk using only the Previser Risk Calculator (Risk group) or supplemented with a GPS-behavioral intervention (GPS group). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/JPER.18-0385DOI Listing

Calcium isotope ratios in blood and urine: A new biomarker for the diagnosis of osteoporosis.

Bone Rep 2019 Jun 16;10:100200. Epub 2019 Mar 16.

Clinical Research Center Kiel GmbH, Schauenburgerstraße 116, 24118 Kiel, Germany.

We assessed the potential of Calcium (Ca) isotope fractionation measurements in blood (δCa) and urine (δCa) as a new biomarker for the diagnosis of osteoporosis. One hundred post-menopausal women aged 50 to 75 years underwent dual-energy X-ray absorptiometry (DXA), the gold standard for determination of bone mineral density. After exclusion of women with kidney failure and vitamin D deficiency (<25 nmol/l) 80 women remained in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bonr.2019.100200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453776PMC
June 2019
1 Read

Enhanced reconstruction in magnetic particle imaging by whitening and randomized SVD approximation.

Phys Med Biol 2019 Apr 17. Epub 2019 Apr 17.

Department of Computer Science, University College London, London, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Magnetic particle imaging (MPI) is a medical imaging modality of recent origin, and it exploits the nonlinear magnetization phenomenon to recover a spatially dependent concentration of nanoparticles. In practice, image reconstruction in MPI is frequently carried out by standard Tikhonov regularization with nonnegativity constraint, which is then minimized by a Kaczmarz type method. In this work, we revisit two issues in the numerical reconstruction in MPI in the lens of inverse theory, i. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6560/ab1a4fDOI Listing

The Human Lung Cell Atlas - A high-resolution reference map of the human lung in health and disease.

Am J Respir Cell Mol Biol 2019 Apr 17. Epub 2019 Apr 17.

University of Groningen, University Medical Center Groningen, Pathology and Medical Biology, Groningen, Netherlands.

Lung disease accounts for every sixth death globally. Profiling the molecular state of all lung cell types in health and disease is currently revolutionizing the identification of disease mechanisms and will aid the design of novel diagnostic and personalized therapeutic regimens. Recent progress in high-throughput techniques for single-cell genomic and transcriptomic analyses has opened up new possibilities to study individual cells within a tissue, classify these into cell types, and characterize variations in their molecular profiles as a function of genetics, environment, cell-cell interactions, developmental processes, ageing or disease. Read More

View Article

Download full-text PDF

Source
https://www.atsjournals.org/doi/10.1165/rcmb.2018-0416TR
Publisher Site
http://dx.doi.org/10.1165/rcmb.2018-0416TRDOI Listing
April 2019
2 Reads
3.985 Impact Factor

The 2019 Mathematical Oncology Roadmap.

Phys Biol 2019 Apr 16. Epub 2019 Apr 16.

Translational Hematology & Oncology Research, Cleveland Clinic, Cleveland, Ohio, UNITED STATES.

Whether the nom de guerre is Mathematical Oncology, Computational or Systems Biology, Theoretical Biology, Evolutionary Oncology, Bioinformatics, or simply Basic Science, there is no denying that mathematics continues to play an increasingly prominent role in cancer research. Mathematical Oncology-defined here simply as the use of mathematics in cancer research-complements and overlaps with a number of other fields that rely on mathematics as a core methodology. As a result, Mathematical Oncology has a broad scope, ranging from theoretical studies to clinical trials designed with mathematical models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1478-3975/ab1a09DOI Listing
April 2019
1 Read

Guidance on prevention of unintended and accidental radiation exposures in nuclear medicine.

J Radiol Prot 2019 Apr 16. Epub 2019 Apr 16.

Australian Radiation Protection and Nuclear Safety Agency, Yallambie, Victoria, AUSTRALIA.

Nuclear medicine (NM) procedures for diagnosis and treatment of disease are performed routinely in hospitals throughout the world. These involve preparation and administration to patients of pharmaceuticals labelled with radioactive material. There is potential for incidents to occur, involving unintended exposures of patients or staff members, throughout all stages of a procedure. Read More

View Article

Download full-text PDF

Source
http://iopscience.iop.org/article/10.1088/1361-6498/ab19d8
Publisher Site
http://dx.doi.org/10.1088/1361-6498/ab19d8DOI Listing
April 2019
1 Read

Osteogenic and angiogenic tissue formation in high fidelity nanocomposite Laponite-gelatin bioinks.

Biofabrication 2019 Apr 16. Epub 2019 Apr 16.

University of Southampton Institute of Developmental Science, Southampton, Hampshire, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Bioprinting of living cells is rapidly developing as an advanced biofabrication approach to engineer tissues. Bioinks can be extruded in three-dimensions (3D) to fabricate complex and hierarchical constructs for implantation. However, lack of functionality can often be attributed to poor bioink properties. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1758-5090/ab19fdDOI Listing
April 2019
1 Read

Prolactin and breast increase during pregnancy in PCOS - linked to long-term metabolic health?

Eur J Endocrinol 2019 Apr 1. Epub 2019 Apr 1.

E Vanky, Department of Obstetrics and Gynecology, Department of Women's and Childrens Health, Norwegian University of Technology and Science, Trondheim, United Kingdom of Great Britain and Northern Ireland.

Objective To explore whether gestational prolactin and breast increase are markers of metabolic health in pregnancy and on long-term, in PCOS. Design Follow-up study. Women with PCOS, according to the Rotterdam criteria (N=239), former participants of the randomized controlled trial (RCT) PregMet were invited, 131 participated in the current follow-up study, at mean 8 years after pregnancy. Read More

View Article

Download full-text PDF

Source
https://eje.bioscientifica.com/view/journals/eje/aop/eje-19-
Publisher Site
http://dx.doi.org/10.1530/EJE-19-0002DOI Listing
April 2019
5 Reads

Life expectancy and the Global Burden of Disease 1990-2016: little cause for complacency.

Authors:
George Ellison

Ann Hum Biol 2019 Apr 16:1-5. Epub 2019 Apr 16.

a Leeds Institute of Cardiovascular and Metabolic Medicine , University of Leeds , Leeds , United Kingdom of Great Britain and Northern Ireland.

While the omission of behavioural and mechanistic factors from the BBC's "Life Expectancy Calculator" might undermine its utility as a health promotion tool, the centrality of these factors within the GBD 2016 Risk Factor Collaborators' analyses - which only detected "important changes" in behavioural (tobacco, alcohol and diet) and mechanistic (low birthweight, short gestation, BMI, blood pressure, fasting glucose) factors - undermines the "important" role that country-level variation in political, social and structural factors plays in the availability of those opportunities, circumstances, habits and behaviours necessary to deliver consistent, resilient and sustained mechanistic improvements in life expectancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/03014460.2019.1607900DOI Listing
April 2019
1 Read

Exploring the abilities of performing complex daily activities in dementia: the effects of supervision on remaining independent.

Aging Ment Health 2019 Apr 16:1-7. Epub 2019 Apr 16.

c CAPHRI School for Public Health and Primary Care , Maastricht University, Maastricht , Netherlands.

Objectives: The aim of this study was to explore the remaining abilities of people with dementia (PwD) in performing daily activities.

Method: Informal carers of community-residing PwD were recruited across England via mail out and carer support groups. Carers completed the revised Interview for Deteriorations in Daily Living Activities in Dementia 2 to rate the PwD's initiative and performance of daily activities. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/13607863.2019.1603283DOI Listing

Ancient genomes indicate population replacement in Early Neolithic Britain.

Nat Ecol Evol 2019 Apr 15. Epub 2019 Apr 15.

Department of Earth Sciences, Natural History Museum, London, UK.

The roles of migration, admixture and acculturation in the European transition to farming have been debated for over 100 years. Genome-wide ancient DNA studies indicate predominantly Aegean ancestry for continental Neolithic farmers, but also variable admixture with local Mesolithic hunter-gatherers. Neolithic cultures first appear in Britain circa 4000 BC, a millennium after they appeared in adjacent areas of continental Europe. Read More

View Article

Download full-text PDF

Source
http://www.nature.com/articles/s41559-019-0871-9
Publisher Site
http://dx.doi.org/10.1038/s41559-019-0871-9DOI Listing
April 2019
13 Reads

'You Can't Dismiss that as Being Less Happy, You See it is Different'. Sexual Counselling in 1950s England.

20 Century Br Hist 2019 Apr 13. Epub 2019 Apr 13.

Cambridge University and St John's College.

This article uses the audio recordings of sexual counselling sessions carried out by Dr Joan Malleson, a birth control activist and committed family planning doctor in the early 1950s, which are held at the Wellcome Library in London as a case study to explore the ways Malleson and the patients mobilised emotions for respectively managing sexual problems and expressing what they understood as constituting a 'good sexuality' in postwar Britain. The article contains two interrelated arguments. First, it argues that Malleson used a psychological framework to inform her clinical work. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/tcbh/hwz008DOI Listing
April 2019
3 Reads

Detection of ultra-low protein concentrations with the simplest possible field effect transistor.

Nanotechnology 2019 Apr 15. Epub 2019 Apr 15.

Department of Chemistry, University College Cork, Western Road, Cork, Cork, IRELAND.

Silicon nanowire (Si NW) sensors have attracted great attention due to their ability to provide fast, low-cost, label-free, real-time detection of chemical and biological species. Usually configured as field effect transistors (FETs), they have already demonstrated remarkable sensitivity with high selectivity (through appropriate functionalisation) towards a large number of analytes in both liquid and gas phases. Despite these excellent results, Si NW FET sensors have not yet been successfully employed to detect single molecules of either a chemical or biological target species. Read More

View Article

Download full-text PDF

Source
http://iopscience.iop.org/article/10.1088/1361-6528/ab192c
Publisher Site
http://dx.doi.org/10.1088/1361-6528/ab192cDOI Listing
April 2019
1 Read

Protein fibrillogenesis model tracked by its intrinsic time-resolved emission spectra.

Methods Appl Fluoresc 2019 Apr 15. Epub 2019 Apr 15.

Department of Physics, Strathclyde University, Glasgow, G4 ONG, UK, Glasgow, G4 0NG, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

The excited-state kinetics of the fluorescence of tyrosine in a de novo protein fibrillogenesis model was investigated as a potential tool for monitoring protein fibre formation and complexation with glucose (glycation). In stark contrast to insulin the time-resolved emission spectra (TRES) recorded over the period of 700 hours in buffered solutions of the model with and without glucose revealed no apparent changes in Tyr fluorescence responses. This indicates the stability of the model and provides a measurement-supported basis for its use as a reference material in fluorescence studies of protein aggregation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/2050-6120/ab1985DOI Listing

Zooming into the Matrix: Using Non-linear Microscopy to Visualise Collagen Remodelling in Asthmatic Airways.

Am J Respir Crit Care Med 2019 Apr 15. Epub 2019 Apr 15.

Imperial College London, Leukocyte Biology Section, National Heart and Lung Institute, London , United Kingdom of Great Britain and Northern Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201904-0722EDDOI Listing

Design of IPF Clinical Trials in the Era of Approved Therapies.

Am J Respir Crit Care Med 2019 Apr 15. Epub 2019 Apr 15.

Cornell Medical College, New York, New York, United States.

The approval of nintedanib and pirfenidone for treatment of idiopathic pulmonary fibrosis has introduced complexity into the design of clinical trials for new drugs on many levels. Placebo-controlled trials excluding background therapy may have issues with feasibility. Those that allow background therapy must consider the possibility of drug-drug interactions with existing therapies, as well as the narrower therapeutic window available to demonstrate incremental slowing of lung function decline with a new agent. Read More

View Article

Download full-text PDF

Source
https://www.atsjournals.org/doi/10.1164/rccm.201903-0592PP
Publisher Site
http://dx.doi.org/10.1164/rccm.201903-0592PPDOI Listing
April 2019
2 Reads

Understanding Lactatemia in Human Sepsis: Potential Impact for Early Management.

Am J Respir Crit Care Med 2019 Apr 15. Epub 2019 Apr 15.

Regions Hospital, St. Paul, Minnesota, United States.

Rationale: Hyperlactatemia in sepsis may derive from a prevalent impairment of oxygen supply/demand and/or oxygen utilization. Discriminating between these two mechanisms may be relevant for the early fluid resuscitation strategy.

Objectives: Understanding the relationship between central venous oxygen saturation (ScvO2), lactate and base excess to better determine the origin of lactate. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201812-2342OCDOI Listing
April 2019
1 Read
12.996 Impact Factor

An improved technique for increasing the accuracy of joint-to-ground distance tracking in kinect v2 for foot-off and foot contact detection.

J Med Eng Technol 2019 Apr 15:1-11. Epub 2019 Apr 15.

a College of Engineering Design and Physical Sciences, Department of Electronics and Computer Engineering , Brunel University London , Uxbridge , United Kingdom of Great Britain and Northern Ireland.

The Kinect sensor has been widely used in different applications such as rehabilitation and gait analysis. Whilst Kinect v2 was released with several improvements over its predecessor, it still incorporates depth-map intrinsic inaccuracies. This results in inconsistencies in skeletal-data acquisition, especially in joint localisation and distance-to-ground tracking with respect to the Kinect's 3-D Cartesian coordinate reference point. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/03091902.2019.1595762DOI Listing

[Systematic review of the methodology quality and reporting quality in colorectal cancer screening guidelines].

Zhonghua Yu Fang Yi Xue Za Zhi 2019 Apr;53(4):398-404

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medial Sciences and Peking Union Medical College, Beijing 100021, China.

To systematically review the quality and reporting quality of colorectal cancer screening guidelines, and to provide reference for the update of colorectal cancer screening guidelines and colorectal cancer screening in China. "Colorectal cancer", "colorectal tumor", "screening", "screening", "guide", "consensus", "Colorectal cancer", "Colorectal neoplasms", "Screening", "Early Detection of Cancer", "Guideline" and "recommendation" were used as search keywords. The literature retrieval for all the Chinese and English guidelines published before April 2018 was conducted by using PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Data, China Biology Medicine disc (CBMdisc), Cochrane Library, Guideline International Network, China Guidelines Clearinghouse (CGC) and the official website of the US Preventive Services Task Force (USPSTF), the American Cancer Society (ACS), International Agency for Research on Cancer (IARC), Australia Cancer Council (ACC) and Association of Coloproctology of Great Britain & Ireland (ACPGBI). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0253-9624.2019.04.013DOI Listing

Corrigendum to 'Smoking and quitting behaviours by mental health conditions in Great Britain (1993-2014)'.

Addict Behav 2019 Apr 10. Epub 2019 Apr 10.

King's College London, Addictions Department, Institute of Psychiatry, Psychology & Neuroscience, 4 Windsor Walk, London SE5 8BB, United Kingdom; UK Centre for Tobacco and Alcohol Studies, United Kingdom.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.addbeh.2019.04.005DOI Listing

The necessity of immediate cardio-thoracic surgical cover for high-risk transvenous lead extraction procedures: the Art of lead extraction.

Int J Cardiol 2019 Apr 3. Epub 2019 Apr 3.

Guy's & St Thomas' NHS Foundation Trust, London SE1 7EH, United Kingdom of Great Britain and Northern Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijcard.2019.04.005DOI Listing

Ab initio study of negative electron affinity from light metals on the oxygen-terminated diamond (111) surface.

J Phys Condens Matter 2019 Apr 12. Epub 2019 Apr 12.

University of Bristol School of Chemistry, Bristol, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Recent computational work has shown that light metals adsorbed onto the oxygenated diamond (100) surface have the potential to give diamond a temperature-stable negative electron affinity (NEA). Here, we use density functional theory to study three of these metals, lithium, magnesium and aluminium, on the (111) surface. We show that all three of these metals adsorbed onto the ketone O-terminated diamond surface can possess a large NEA and adsorption energies above that of H-termination at monolayer (ML) or sub-ML coverages. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-648X/ab18efDOI Listing
April 2019
1 Read

Crystal field coefficients for yttrium analogues of rare-earth/transition-metal magnets using density-functional theory in the projector-augmented wave formalism.

J Phys Condens Matter 2019 Apr 12. Epub 2019 Apr 12.

Department of Physics, University of Warwick, Coventry, West Midlands, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

We present a method of calculating crystal field coefficients of rare-earth/transition-metal (RE-TM) magnets within density-functional theory (DFT). The principal idea of the method is to calculate the crystal field potential of the yttrium analogue ("Y-analogue") of the RE-TM magnet, i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-648X/ab18f3DOI Listing

Binding potentials for vapour nanobubbles on surfaces using density functional theory.

J Phys Condens Matter 2019 Apr 12. Epub 2019 Apr 12.

Department of Mathematical Sciences, Loughborough University, Loughborough, Leics, LE11 3TU, Loughborough, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

We calculate one-body density profiles of a simple model fluid in contact with a planar surface using density functional theory (DFT), in particular for the case where there is a vapour layer intruding between the wall and the bulk liquid. We apply the method of Hughes \emph{et al.}\ [J. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-648X/ab18e8DOI Listing

Humulus japonicus stimulates thermogenesis and ameliorates oxidative stress in mouse adipocytes.

J Mol Endocrinol 2019 Apr 1. Epub 2019 Apr 1.

J Jeong, Pharmacology, Chung-Ang University, Seoul, Korea (the Republic of).

An aqueous extract of Humulus japonicus (AH) has been documented to ameliorate hypertension and non-alcoholic fatty liver disease (NAFLD). Here, we investigated the effects of an aqueous extract of AH on thermogenesis and palmitate-induced oxidative stress in adipocytes. To verify the effect of AH on browning, we measured the expression levels of specific markers in 3T3-L1 adipocytes using qPCR and Western blotting, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1530/JME-19-0010DOI Listing

Questionnaire survey on helminth control practices in horse farms in Ireland.

Parasitology 2019 Apr 12:1-10. Epub 2019 Apr 12.

School of Veterinary Medicine, University College Dublin,Dublin,Ireland.

Knowledge regarding helminth control strategies and nematode infection of horses in Ireland is limited and only one study has been published recently. This present study was designed to investigate the current helminth control strategies followed by horse owners in Ireland. A questionnaire was formulated to collect data on general grazing, pasture management and deworming strategies including the use of fecal egg counts. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S0031182019000271DOI Listing

Paradigms in operation: explaining pharmaceutical benefit assessment outcomes in England and Germany.

Health Econ Policy Law 2019 Apr 12:1-16. Epub 2019 Apr 12.

Department of Political Science,University of Vienna,Universitätsstr. 7, 1010 Vienna,Austria.

Health technology assessments (HTAs) are used as a policy tool to appraise the clinical value, or cost effectiveness, of new medicines to inform reimbursement decisions in health care. As HTA organisations have been established in different countries, it has become clear that the outcomes of medicine appraisals can vary from country to country, even though the same scientific evidence in the form of randomised controlled trials is available. The extant literature explains such variations with reference to institutional variables and administrative rules. Read More

View Article

Download full-text PDF

Source
https://www.cambridge.org/core/product/identifier/S174413311
Publisher Site
http://dx.doi.org/10.1017/S1744133119000203DOI Listing
April 2019
2 Reads

Detection of Neospora caninum DNA in cases of bovine and ovine abortion in the South-West of Scotland.

Parasitology 2019 Apr 12:1-4. Epub 2019 Apr 12.

Moredun Research Institute, Pentlands Science Park,Bush Loan, Penicuik, EH26 0PZ,Scotland,UK.

Neospora caninum is a commonly diagnosed cause of reproductive losses in farmed ruminants worldwide. This study examined 495 and 308 samples (brain, heart and placenta) which were collected from 455 and 119 aborted cattle and sheep fetuses, respectively. DNA was extracted and a nested Neospora ITS1 PCR was performed on all samples. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1017/S0031182019000301DOI Listing
April 2019
4 Reads

Protective ventilation with high versus low positive end-expiratory pressure during one-lung ventilation for thoracic surgery (PROTHOR): study protocol for a randomized controlled trial.

Trials 2019 Apr 11;20(1):213. Epub 2019 Apr 11.

Department of Anaesthesiology and Intensive Care, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey.

Background: Postoperative pulmonary complications (PPC) may result in longer duration of in-hospital stay and even mortality. Both thoracic surgery and intraoperative mechanical ventilation settings add considerably to the risk of PPC. It is unclear if one-lung ventilation (OLV) for thoracic surgery with a strategy of intraoperative high positive end-expiratory pressure (PEEP) and recruitment maneuvers (RM) reduces PPC, compared to low PEEP without RM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-019-3208-8DOI Listing
April 2019
2 Reads

Controlling the growth of single crystal ZnO nanowires by tuning the atomic layer deposition parameters of the ZnO seed layer.

Nanotechnology 2019 Apr 11. Epub 2019 Apr 11.

Department of Physics, Durham University, South Road, Durham, DH1 3LE, Durham, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Semiconducting nanowires (NWs) offer exciting prospects for a wide range of technological applications. The translation of NW science into technology requires reliable high-quality large volume production. This study provides an in-depth investigation of the parameters using an atomic layer deposition (ALD) system to grow zinc oxide (ZnO) seed layers followed by the chemical bath deposition of ZnO nanowires (NWs) to demonstrate the low-cost production of uniform single crystal wurtzite phase ZnO NWs that is scalable to large area substrates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1088/1361-6528/ab186aDOI Listing

Zebrafish otolith biomineralization requires polyketide synthase.

Mech Dev 2019 Apr 8. Epub 2019 Apr 8.

Department of Biomedical Sciences, Creighton University School of Medicine, Omaha, NE, United States. Electronic address:

Deflecting biomineralized crystals attached to vestibular hair cells are necessary for maintaining balance. Zebrafish (Danio rerio) are useful organisms to study these biomineralized crystals called otoliths, as many required genes are homologous to human otoconial development. We sought to identify and characterize the causative gene in a trio of homozygous recessive mutants, no content (nco) and corkscrew (csr), and vanished (vns), which fail to develop otoliths during early ear development. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mod.2019.04.001DOI Listing

Public health interventions via mobile phone digital technology to reduce rates of sexually transmitted infections.

J Public Health (Oxf) 2019 Mar;41(1):e61

Department of Sexual Heath & HIV, Brighton & Sussex University NHS Trust, Brighton, UK.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/pubmed/fdy052DOI Listing

The Mortality Burden of Idiopathic Pulmonary Fibrosis in the United Kingdom.

Am J Respir Crit Care Med 2019 Apr 11. Epub 2019 Apr 11.

Nottingham University, Nottingham, United Kingdom of Great Britain and Northern Ireland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1164/rccm.201902-0467LEDOI Listing
April 2019
1 Read

Pedestrian crashes at priority-controlled junctions, roundabouts, and signalized junctions: The UK case study.

Traffic Inj Prev 2019 Apr 11:1-6. Epub 2019 Apr 11.

c Qatar Transportation and Traffic Safety Studies Centre , Qatar University , Doha , Qatar.

Objectives: Over half of pedestrians killed and seriously injured in Great Britain in 2015 were involved in crashes at junctions. This study investigates the nature of these crashes.

Methods: A study was conducted into pedestrian casualty crashes at priority controlled junctions, roundabouts and signalised junctions in England between 2005 and 2015 using information from the UK STATS19 accident database, the UK National Travel Survey and the UK National Census. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/15389588.2019.1574972DOI Listing