21,573 results match your criteria Britain And The World[Journal]


Curve Sprinting in Soccer: Kinematic and Neuromuscular Analysis.

Int J Sports Med 2020 Jun 3. Epub 2020 Jun 3.

NAR - Nucleus of High Performance in Sport, Sport Science, São Paulo, Brazil.

Sprinting in curvilinear trajectories is an important soccer ability, corresponding to ~85% of the actions performed at maximum velocity in a soccer league. We compared the neuromuscular behavior and foot contact-time between outside leg and inside leg during curve sprinting to both sides in soccer players. Nine soccer players (age=23±4. Read More

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http://dx.doi.org/10.1055/a-1144-3175DOI Listing

A luminescent solar concentrator ray tracing simulator with a graphical user interface: Features and applications.

Methods Appl Fluoresc 2020 Jun 3. Epub 2020 Jun 3.

University of Melbourne School of Chemistry, Parkville, Victoria, AUSTRALIA.

A Monte-Carlo ray tracing simulator with a graphical user interface (MCRTS-GUI) has been developed to provide a quantitative description, performance evaluation and photon loss analysis of luminescent solar concentrators (LSCs). The algorithm is applied to several practical LSC device structures including multiple dyes in the same waveguiding layer, and structures where a dye layer is sandwiched between clear substrates. The effect of the host matrix absorption and the influence of the neighboring layers are investigated. Read More

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http://dx.doi.org/10.1088/2050-6120/ab993dDOI Listing

Effect of aluminium concentration on phase formation and radiation stability of Cr2AlxC thin film.

Nanotechnology 2020 Jun 3. Epub 2020 Jun 3.

Centre for Engineering Materials (CEM), University of Huddersfield School of Computing and Engineering, Huddersfield, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Near stoichiometric and under stochiometric Cr2AlxC (x=0.9 and 0.75) amorphous compositions were deposited onto silicon substrate at 330 K in a layer-by-layer fashion using magnetron sputtering from elemental targets. Read More

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http://dx.doi.org/10.1088/1361-6528/ab991cDOI Listing

Senior nurses' perceptions of junior nurses incident reporting: A qualitative study.

J Nurs Manag 2020 Jun 3. Epub 2020 Jun 3.

School of Health and Social Care/Adult Nursing and Midwifery Studies, London South Bank University, 103 Borough Road, London, SE1 OAA, United Kingdom of Great Britain and Northern Ireland.

Aim: To develop an understanding of senior nurses ranking and perceptions of incident reporting by junior nurses.

Background: Nurses must be encouraged to report incidents to nursing management. It is important to ascertain how senior nurses perceive their concerns, as it is crucial to ensuring that patient safety are managed. Read More

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http://dx.doi.org/10.1111/jonm.13063DOI Listing

Monte-Carlo-computed dose, kerma and fluence distributions in heterogeneous slab geometries irradiated by small megavoltage photon fields.

Phys Med Biol 2020 Jun 2. Epub 2020 Jun 2.

Dept of Radiation Oncology, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202-2689, USA, Detroit, Michigan, UNITED STATES.

Small-field dosimetry is central to the planning and delivery of radiotherapy to patients with cancer. Small-field dosimetry is beset by complex issues, such as loss of charged-particle equilibrium (CPE), source occlusion and electron scattering effects in low-density tissues. The purpose of the present research was to elucidate the fundamental physics of small fields through the computation of absorbed dose, kerma and fluence distributions in heterogeneous media using the Monte-Carlo method. Read More

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http://dx.doi.org/10.1088/1361-6560/ab98d1DOI Listing

Imprint and transfer fabrication of freestanding plasmonic membranes.

Nanotechnology 2020 Jun 2. Epub 2020 Jun 2.

Electrical and Computer Engineering, Iowa State University, Ames, Iowa, UNITED STATES.

This paper reports an imprint and transfer approach for the rapid and inexpensive fabrication of the ultra-thin freestanding plasmonic membrane (FPM) that supports surface plasmon resonances. The imprint and transfer fabrication method involves the soft imprint lithography on an ultrathin polymer film, transfer of the perforated polymer film to a supporting frame, subsequent deposition of gold, and final removal of the polymer film. Without using any sophisticated lithography and etching processes, the imprint and transfer method can produce freestanding gold membranes with 2D arrays of submicrometer-sized holes that support plasmonic modes in the mid-wavelength infrared (mid-IR) range. Read More

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http://dx.doi.org/10.1088/1361-6528/ab98bfDOI Listing

When echo gets in the way: physiological factors affecting Doppler data.

Echo Res Pract 2020 May 1. Epub 2020 May 1.

J Khoo, Cardiology, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom of Great Britain and Northern Ireland.

Transthoracic echocardiography (TTE) is widely used as a pre-operative screening tool. It can provide extensive information about cardiac function and underlying pathology, which could influence decisions regarding surgery. This patient was referred for TTE as part of the pre-op screening, as he had a biological prosthetic aortic valve. Read More

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http://dx.doi.org/10.1530/ERP-20-0006DOI Listing

Cell population characterisation and discovery using single cell technologies in endocrine systems.

J Mol Endocrinol 2020 Jun 1. Epub 2020 Jun 1.

K Rizzoti, Stem Cell Biology and Developmental Genetics, Francis Crick Institute, London, United Kingdom of Great Britain and Northern Ireland.

In the last 15 years, single-cell technologies have become robust and indispensable tools to investigate cell heterogeneity. Beyond transcriptomic, genomic and epigenome analyses, technologies are constantly evolving, in particular toward multi-omics, where analyses of different source materials from a single cell are combined, and spatial transcriptomics where resolution of cellular heterogeneity can be detected in situ. While some of these techniques are still being optimised, single-cell RNAseq has commonly been used because the examination of transcriptomes allows characterization of cell identity, and therefore unravel previously uncharacterised diversity within cell populations. Read More

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http://dx.doi.org/10.1530/JME-19-0276DOI Listing

Pathological Comparisons of Paraseptal and Centrilobular Emphysema in COPD.

Am J Respir Crit Care Med 2020 Jun 2. Epub 2020 Jun 2.

The University of British Columbia Centre for Heart Lung Innovation, 539747, Vancouver, British Columbia, Canada.

Rationale: While centrilobular (CLE) and paraseptal (PSE) emphysema are commonly identified on multi-detector computed tomography (MDCT), little is known about the pathology associated with PSE compared to CLE.

Objective: To assess the pathological differences between PSE and CLE in chronic obstructive pulmonary disease (COPD).

Methods: Air-inflated frozen lung specimens (n=6) obtained from patients with severe COPD treated by lung transplantation were scanned with MDCT. Read More

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http://dx.doi.org/10.1164/rccm.201912-2327OCDOI Listing

Cultivating famine: data, experimentation and food security, 1795-1848.

Br J Hist Sci 2020 Jun 2:1-23. Epub 2020 Jun 2.

Centre for the History of Science, Medicine and Technology, University of Oxford, Oxford, OX1 2JD, UK. Email:

Collecting seeds and specimens was an integral aspect of botany and natural history in the eighteenth century. Historians have until recently paid less attention to the importance of collecting, trading and compiling knowledge of their cultivation, but knowing how to grow and maintain plants free from disease was crucial to agricultural and botanical projects. This is particularly true in the case of food security. Read More

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http://dx.doi.org/10.1017/S0007087420000199DOI Listing

Commentary on Some Recent Theses Relevant to Combating Aging: June 2020.

Rejuvenation Res 2020 Jun 2. Epub 2020 Jun 2.

SENS Research Foundation, 110 Pioneer Way, Ste J., Mountainview, California, United States, 94041.

Theses reviewed in this issue include "Clearance of Capillary Occlusions Improves Cortical Blood Flow and Cognitive Function in Alzheimer's Mouse Models", "Dermato-informatic approaches to understanding and improving lesional diagnostic expertise in cutaneous oncology", "Furthering the Scope, Understanding, and Application of Proteolysis Targeting Chimera", "Optimization and Application of Synthetic High-Density Lipoprotein (sHDL) System in Atherosclerosis and Glioma Therapy", "Regulatory T Cell Enriching Microparticles for Promoting Tolerance in Vascularized Composite Allotransplantation", and "Tau Prion Strains Induce Distinct Pathological Phenotypes In Vivo". Read More

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http://dx.doi.org/10.1089/rej.2020.2358DOI Listing

Returning to Play after Prolonged Training Restrictions in Professional Collision Sports.

Int J Sports Med 2020 May 29. Epub 2020 May 29.

Department for Health, University of Bath, Bath, United Kingdom of Great Britain and Northern Ireland.

The COVID-19 pandemic in 2020 has resulted in widespread training disruption in many sports. Some athletes have access to facilities and equipment, while others have limited or no access, severely limiting their training practices. A primary concern is that the maintenance of key physical qualities (e. Read More

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http://dx.doi.org/10.1055/a-1180-3692DOI Listing

Post-exercise provision of 40 g of protein during whole body resistance training further augments strength adaptations in elderly males.

Res Sports Med 2020 Jun 1:1-15. Epub 2020 Jun 1.

Department of Sport and Physical Activity, Edge Hill University, Sports Nutrition and Performance Research Group , Ormskirk, United Kingdom of Great Britain and Northern Ireland.

Background:  In the elderly, low protein intake exacerbates the effects of sarcopenia and anabolic resistance.  Protein supplementation to maximise muscle protein synthesis, may be an effective intervention. Aim: To determine the effects of a low/high dose of protein, ingested immediately post-exercise, during resistance training in novice elderly males. Read More

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http://dx.doi.org/10.1080/15438627.2020.1770251DOI Listing

Phosphate Porous Coatings Enriched with Selected Elements via PEO Treatment on Titanium and Its Alloys: A Review.

Materials (Basel) 2020 May 28;13(11). Epub 2020 May 28.

Faculty of Mechanical Engineering, Koszalin University of Technology, Racławicka 15-17, PL 75-620 Koszalin, Poland.

This paper shows that the subject of porous coatings fabrication by Plasma Electrolytic Oxidation (PEO), known also as Micro Arc Oxidation (MAO), is still current, inter alia because metals and alloys, which can be treated by the PEO method, for example, titanium, niobium, tantalum and their alloys, are increasingly available for sale. On the international market, apart from scientific works/activity developed at universities, scientific research on the PEO coatings is also underway in companies such as Keronite (Great Britain), Magoxid-Coat (Germany), Mofratech (France), Machaon (Russia), as well as CeraFuse, Tagnite, Microplasmic (USA). In addition, it should be noted that the development of the space industry and implantology will force the production of trouble-free micro- and macro-machines with very high durability. Read More

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http://dx.doi.org/10.3390/ma13112468DOI Listing

Quantification of the Animal Tuberculosis Multi-Host Community Offers Insights for Control.

Pathogens 2020 May 28;9(6). Epub 2020 May 28.

SaBio Instituto de Investigación en Recursos Cinegéticos IREC (UCLM & CSIC), 13005 Ciudad Real, Spain.

Animal tuberculosis (TB) is a multi-host zoonotic disease whose prevalence in cattle herds in Europe has been increasing, despite a huge investment in eradication. The composition of the host community is a fundamental driver of pathogen transmission, and yet this has not been formally quantified for animal TB in Europe. We quantified multi-host communities of animal TB, using stochastic models to estimate the number of infected domestic and wild hosts in three regions: officially TB-free Central-Western Europe, and two largely TB-endemic regions, the Iberian Peninsula and Britain and Ireland. Read More

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http://dx.doi.org/10.3390/pathogens9060421DOI Listing

Interleukin-6 Blockade Treatment for COVID-19 associated Cytokine Release Syndrome in a Patient with Poorly Controlled Chronic Myeloid Leukaemia.

Br J Haematol 2020 Jun 1. Epub 2020 Jun 1.

Hillingdon Hospitals NHS Foundation Trust, Department of Haematology, Uxbridge, United Kingdom of Great Britain and Northern Ireland.

In December 2019, a novel coronavirus pneumonia, coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) was reported in Wuhan, China. A hyperinflammatory immune response, or cytokine release syndrome (CRS) is observed in critically unwell patients with SARS-CoV-2 globally. Severe lymphopenia, hyperactivated pro-inflammatory T cells and decreased regulatory T cells are seen in these critically ill patients, suggesting dysregulated immune responses. Read More

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http://dx.doi.org/10.1111/bjh.16901DOI Listing

Characterization of the PTW-34089 type 147 mm diameter large-area ionization chamber for use in light-ion beams.

Phys Med Biol 2020 Jun 1. Epub 2020 Jun 1.

Centre for Ionising Radiation Metrology, NPL, TEDDINGTON, Middlesex, TW11 0LW, Teddington, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

A newly-designed large-area plane-parallel ionization chamber (of type PTW 34089), denoted BPC150, with a nominal active volume diameter of 147 mm is characterized in this study. Such chambers exhibit benefits compared to smaller chambers in the field of scanned light-ion beam dosimetry because they capture a larger fraction of the laterally-spread beam fragments and ease positioning with respect to small fields. The chamber was characterized inCo, 200 kV X-ray, proton and carbon ion beams. Read More

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http://dx.doi.org/10.1088/1361-6560/ab9852DOI Listing

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study.

Authors:

Lancet 2020 May 29. Epub 2020 May 29.

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection.

Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. Read More

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http://dx.doi.org/10.1016/S0140-6736(20)31182-XDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259900PMC

Chemical composition of microplastic in sediments and protected detritivores from different marine habitats (Salina Island).

Mar Pollut Bull 2020 Mar 17;152:110918. Epub 2020 Feb 17.

Department of Science for the Environment, University of Naples Parthenope, via A. De Gasperi, 5, 80133 Naples, Italy.

This study estimates chemical composition of microplastic in sediments and benthic detritivores (sea cucumbers) collected from different marine rocky bottom habitat types (bank, landslide, cliff) of Salina Island (Aeolian Archipelago, Italy). Also, species richness and bottom coverings by benthic species were recorded at each sampling station. Correlations among chemical composition of microplastic in sediments and in detritivores were explored linking recorded variability to the factor "habitat type". Read More

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http://dx.doi.org/10.1016/j.marpolbul.2020.110918DOI Listing

Shall I tell my mentor? Exploring the mentor-student relationship and its impact on students' raising concerns on clinical placement.

J Clin Nurs 2020 Jun 1. Epub 2020 Jun 1.

School of Healthcare Science, Cardiff University, Cardiff, United Kingdom of Great Britain and Northern Ireland.

Aims: To explore student nurses' and nurse mentors' perceptions and experiences of raising concerns on clinical placement and the influence (if any) of their relationship on this process. A secondary aim is to consider the above, from a regulatory perspective in light of current literature and policy developments.

Background: Raising concerns whilst on clinical placement has been shown to be challenging for student nurses internationally. Read More

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http://dx.doi.org/10.1111/jocn.15356DOI Listing

High levels of acquired HIV drug resistance following virological non-suppression in HIV-infected women from a high-risk cohort in Uganda.

AIDS Res Hum Retroviruses 2020 May 30. Epub 2020 May 30.

MRC/UVRI & LSHTM Uganda Research Unit, Uganda Virus Research Institute, Plot 51 - 59 Nakiwogo Road, P.O.Box 49, Entebbe, Uganda.

HIV drug resistance (HIVDR) is of increasing health concern, especially among key populations. We investigated the prevalence of virological suppression (VS), prevalence and correlates of HIVDR in HIV-infected women, enrolled in a high-risk cohort. We enrolled 267 women initiated on first-line antiretroviral therapy (ART) between 2015 and 2018. Read More

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http://dx.doi.org/10.1089/AID.2019.0279DOI Listing

COVID-19-associated acute disseminated encephalomyelitis (ADEM).

J Neurol 2020 May 30. Epub 2020 May 30.

The Hospital of Central Connecticut, Hartford Healthcare, 100 Grand St., New Britain, CT, 06052, USA.

A 51-year-old woman with COVID-19 infection developed coma and an impaired oculocephalic response to one side. MRI of the brain demonstrated acute multifocal demyelinating lesions, and CSF testing did not identify a direct cerebral infection. High-dose steroids followed by a course of IVIG was administered, and the patient regained consciousness over the course of several weeks. Read More

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http://dx.doi.org/10.1007/s00415-020-09951-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260459PMC

Reducing medication errors and transitions of care.

Authors:
Karen Cardwell

Age Ageing 2020 May 30. Epub 2020 May 30.

Queen's University Belfast - Northern Ireland Centre for Pharmacy Learning and Development, United Kingdom of Great Britain and Northern Ireland, Belfast, Belfast.

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http://dx.doi.org/10.1093/ageing/afaa065DOI Listing

'[Her] hostess … is anxious to have her back when she is cured': The impact of the evacuation of children on wartime local services, England, 1939-1945.

Authors:
Jonathan Taylor

Med Humanit 2020 May 29. Epub 2020 May 29.

Faculty of History, University of Oxford, Oxford, UK

World War II had a profound, but uneven, impact on the delivery of services designed to support the bodies and minds of English children. This article, which is based on a study of a rural local authority located in North-West England, explores the influence of World War II on children's welfare services. Drawing on detailed case files relating to individual children and reports published by local and national policy makers, the article advances three related arguments which together nuance existing understandings of the conflict and its longer-term consequences. Read More

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http://dx.doi.org/10.1136/medhum-2019-011784DOI Listing

In response to "Role of Telehealth in the Management of COVID-19: Lessons Learned from Previous SARS, MERS, and Ebola Outbreaks".

Authors:
Anna Dunnigan

Telemed J E Health 2020 May 29. Epub 2020 May 29.

Institute of Clinical Trials and Methodology, University College London, London, United Kingdom of Great Britain and Northern Ireland.

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http://dx.doi.org/10.1089/tmj.2020.0141DOI Listing

An introduction to economic studies, health emergencies, and COVID-19.

Authors:
Lorcan Clarke

J Evid Based Med 2020 May;13(2):161-167

London School of Economics and Political Science, London, United Kingdom of Great Britain.

The COVID-19 pandemic has created widespread harm and disruption. Countries have implemented unprecedented measures to protect the lives and livelihoods of their inhabitants. The scope and composition of these responses are shaped, in part, by research and analysis about the estimated economic impacts of the COVID-19 Pandemic and proposed responses to it. Read More

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http://dx.doi.org/10.1111/jebm.12395DOI Listing

A reflection on an adapted approach from face-to-face to telephone consultations in our Urology outpatient department during the COVID-19 pandemic - a pathway for change to future practice?

BJU Int 2020 May 29. Epub 2020 May 29.

Department of Urology, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom of Great Britain and Northern Ireland.

The sudden and unanticipated COVID-19 viral pandemic of 2020 and its profound impact on the NHS prompted an almost overnight change in the services we are able to offer our patients to fulfil clinical demands. From March 2020 we have changed outpatient appointments from face-to-face to telephone led consultations. We have performed an early review of this service to ensure its sustainability during the unknown duration of this current crisis and to establish its potential utility when normal services resume in the future. Read More

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http://dx.doi.org/10.1111/bju.15119DOI Listing

Fourth Consensus Guidelines for the Management of Postoperative Nausea and Vomiting.

Anesth Analg 2020 May 27. Epub 2020 May 27.

Department of Anesthesiology, and Perioperative and Pain Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, Massachusetts.

This consensus statement presents a comprehensive and evidence-based set of guidelines for the care of postoperative nausea and vomiting (PONV) in both adult and pediatric populations. The guidelines are established by an international panel of experts under the auspices of the American Society of Enhanced Recovery and Society for Ambulatory Anesthesia based on a comprehensive search and review of literature up to September 2019. The guidelines provide recommendation on identifying high-risk patients, managing baseline PONV risks, choices for prophylaxis, and rescue treatment of PONV as well as recommendations for the institutional implementation of a PONV protocol. Read More

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http://dx.doi.org/10.1213/ANE.0000000000004833DOI Listing

Abrupt changes in Great Britain vegetation carbon projected under climate change.

Glob Chang Biol 2020 May 28. Epub 2020 May 28.

Global Systems Institute, College of Life and Environmental Sciences, University of Exeter, Exeter, UK.

Past abrupt 'regime shifts' have been observed in a range of ecosystems due to various forcing factors. Large-scale abrupt shifts are projected for some terrestrial ecosystems under climate change, particularly in tropical and high-latitude regions. However, there is very little high-resolution modelling of smaller-scale future projected abrupt shifts in ecosystems, and relatively less focus on the potential for abrupt shifts in temperate terrestrial ecosystems. Read More

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http://dx.doi.org/10.1111/gcb.15144DOI Listing

Neuropathological and biochemical investigation of Hereditary Ferritinopathycases with ferritin light chain mutation: Prominent protein aggregation in the absence of major mitochondrial or oxidative stress.

Neuropathol Appl Neurobiol 2020 May 28. Epub 2020 May 28.

Wolfson Building, Newcastle University, Claremont Place, Newcastle upon Tyne, NE2 4AA, UK.

Aims: Neuroferritinopathyor Hereditary Ferritinopathy (HF)is an autosomal dominant movement disorder due to mutation in the light chain of the iron storage protein ferritin (FTL).HF is the only late-onset neurodegeneration with brain iron accumulation disorder andstudy of HF offers a unique opportunity to understand the role of iron in more common neurodegenerative syndromes.

Methods: We carried out pathological and biochemical studies of six individuals with the same pathogenic FTL mutation. Read More

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http://dx.doi.org/10.1111/nan.12634DOI Listing

Reply to: TMEM16A Potentiation: Possible Drawbacks.

Am J Respir Crit Care Med 2020 May 28. Epub 2020 May 28.

Enterprise Therapeutics Ltd, 484604, Brighton, United Kingdom of Great Britain and Northern Ireland;

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http://dx.doi.org/10.1164/rccm.202004-1214LEDOI Listing

Standardized Map of Iodine Status in Europe.

Thyroid 2020 May 28. Epub 2020 May 28.

Ernst Moritz Arndt University, Institute for Community Medicine, Rathenaustr. 48, Greifswald, Germany, D-17487;

Background Knowledge about the population's iodine status is important, because it allows adjustment of iodine supply and prevention of iodine deficiency. The validity and comparability of iodine related population studies can be improved by standardization, which was one of the goals of the EUthyroid project. The aim of this study was to establish the first standardized map of iodine status in Europe by using standardized UIC data. Read More

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http://dx.doi.org/10.1089/thy.2019.0353DOI Listing

A clone resource of Magnaporthe oryzae effectors that share sequence and structural similarities across host-specific lineages.

Mol Plant Microbe Interact 2020 May 27. Epub 2020 May 27.

Sainsbury Laboratory, 66081, Norwich, Norfolk, United Kingdom of Great Britain and Northern Ireland.

The blast fungus Magnaporthe oryzae (Syn. Pyricularia oryzae) is a destructive plant pathogen that can infect about 50 species of both wild and cultivated grasses, including important crops such as rice and wheat. M. Read More

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http://dx.doi.org/10.1094/MPMI-03-20-0052-ADOI Listing

The Landscape of Coding and Non-coding RNAs in Platelets.

Antioxid Redox Signal 2020 May 28. Epub 2020 May 28.

King's College London, 4616, School of Cardiovascular Medicine & Sciences, 125 Coldharbour Lane, London, United Kingdom of Great Britain and Northern Ireland, SE5 9NU;

Significance: Levels of platelet non-coding RNAs are altered by disease, and non-coding RNAs may exert functions inside and outside of platelets. Their role in physiologic haemostasis and pathologic thrombosis remains to be explored. Recent Advances: The number of RNA classes identified in platelets has been growing in the last decade. Read More

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http://dx.doi.org/10.1089/ars.2020.8139DOI Listing

Computational modeling of the auditory brainstem response to continuous speech.

J Neural Eng 2020 May 27. Epub 2020 May 27.

Bioengineering, Imperial College London, London, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.

Objective: The auditory brainstem response can be recorded non-invasively from scalp electrodes and serves as an important clinical measure of hearing function. We have recently shown how the brainstem response at the fundamental frequency of continuous, non-repetitive speech can be measured, and have used this measure to demonstrate that the response is modulated by selective attention. However, different parts of the speech signal as well as several parts of the brainstem contribute to this response. Read More

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http://dx.doi.org/10.1088/1741-2552/ab970dDOI Listing

Metabolic syndrome is associated with reduced flow mediated dilation independent of obesity status.

Eur J Endocrinol 2020 May 1. Epub 2020 May 1.

D Cuthbertson , Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom of Great Britain and Northern Ireland.

Background: Data suggest that metabolic health status, incorporating components of metabolic syndrome (MetS), predicts cardiovascular disease (CVD) risk better than body mass index (BMI). This study explored the association of MetS and obesity with endothelial function.

Methods: Forty-four participants were phenotyped according to BMI as non-obese vs. Read More

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http://dx.doi.org/10.1530/EJE-20-0098DOI Listing

Hemostatic spray powder TC-325 in the primary endoscopic treatment of peptic ulcer related bleeding: multicentre international registry.

Endoscopy 2020 May 26. Epub 2020 May 26.

University College London Hospitals NHS Foundation Trust, Gastroenterology, London, United Kingdom of Great Britain and Northern Ireland.

Introduction Upper gastrointestinal bleeding (UGIB) is a leading cause of morbidity and associated with a 2-17% mortality in the United Kingdom (UK) and USA [1]. Peptic ulcers account for 50% of UGIB's. Endoscopic intervention in a timely manner can improve outcomes. Read More

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http://dx.doi.org/10.1055/a-1186-5360DOI Listing

Imaging and targeting coronary artery inflammation.

Antioxid Redox Signal 2020 May 27. Epub 2020 May 27.

University of Oxford, 6396, Radcliffe Department of Medicine, Oxford, United Kingdom of Great Britain and Northern Ireland;

Significance Coronary artery disease (CAD) continues to be a leading cause of morbidity and mortality across the world despite significant progress in prevention, diagnosis and treatment of atherosclerotic disease. Recent Advances The focus of the cardiovascular community has shifted towards seeking a better understanding of the inflammatory mechanisms driving residual CAD risk not modulated by current therapies. Significant progress has been achieved in revealing both pro-inflammatory and anti-inflammatory mechanisms, and how shift of the balance in favour of the former, can drive the development of disease. Read More

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http://dx.doi.org/10.1089/ars.2020.8128DOI Listing

Resting-State Network Patterns Underlying Cognitive Function in Bipolar Disorder: A Graph Theoretical Analysis.

Brain Connect 2020 May 27. Epub 2020 May 27.

Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, H91 TK33 Galway, Ireland, Galway, Ireland;

Background: Synchronous and antisynchronous activity between neural elements at rest reflects the physiological processes underlying complex cognitive ability. Regional and pairwise-connectivity investigations suggest perturbations in these activity patterns may relate to widespread cognitive impairments seen in bipolar disorder (BD). Here we take a network-based perspective to more meaningfully capture interactions among distributed brain regions compared to focal measurements and examine network-cognition relationships across a range of commonly affected cognitive domains in BD in relation to healthy controls. Read More

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http://dx.doi.org/10.1089/brain.2019.0709DOI Listing

Brain Network Measures for Groups of Nodes: Application to Normal Aging and Alzheimer's Disease.

Brain Connect 2020 May 27. Epub 2020 May 27.

University of Jaffna - Vavuniya Campus, 119006, Faculty of Applied Science, Vavuniya Campus of the University of Jaffna, Vavuniya, Sri Lanka, 43000;

Background: The nodal brain network measures (e.g. centrality measures) are defined for a single node and the global network measures (e. Read More

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http://dx.doi.org/10.1089/brain.2020.0747DOI Listing

On barring the vascular gateway against severe COVID-19 disease.

Cell Stress Chaperones 2020 May 26. Epub 2020 May 26.

Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT, 06269, USA.

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http://dx.doi.org/10.1007/s12192-020-01122-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250245PMC

Workload Monitoring in Top-level Soccer Players During Congested Fixture Periods.

Int J Sports Med 2020 May 26. Epub 2020 May 26.

School of Health and Sports Sciences, University of Suffolk, Ipswich, United Kingdom of Great Britain and Northern Ireland.

This study assessed the internal and external workload of starters and non-starters in a professional top-level soccer team during a congested fixture period. Twenty Serie A soccer players were monitored in this study during two mesocycles of 21 days each. Starters and non-starters were divided based on the match time played in each mesocycle. Read More

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http://dx.doi.org/10.1055/a-1171-1865DOI Listing

Quantitative Redox Biology of Exercise.

Int J Sports Med 2020 May 26. Epub 2020 May 26.

Centre for Atherothrombotic & Metabolic Disease, Hull York Medical School, Hull, United Kingdom of Great Britain and Northern Ireland.

Biology is rich in claims that reactive oxygen and nitrogen species are involved in every biological process and disease. However, many quantitative aspects of redox biology remain elusive. The important quantitative parameters you need to address the feasibility of redox reactions in vivo are: rate of formation and consumption of a reactive oxygen and nitrogen species, half-life, diffusibility and membrane permeability. Read More

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http://dx.doi.org/10.1055/a-1157-9043DOI Listing

Neonatal EEG sleep stage classification based on deep learning and HMM.

J Neural Eng 2020 May 26. Epub 2020 May 26.

faculty of Medicine, University of Picardie-Jules Verne, Amiens, FRANCE.

Automatic sleep stage scoring is of great importance for investigating sleep architecture during infancy. In this work, we introduce a novel multichannel approach based on deep learning networks and hidden Markov models (HMM) to improve the accuracy of sleep stage classification in term neonates. The classification performance was evaluated on quiet sleep (QS) and active sleep (AS) stages, each with two sub-states, using multichannel EEG data recorded from sixteen neonates with postmenstrual age of 38-40 weeks. Read More

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http://dx.doi.org/10.1088/1741-2552/ab965aDOI Listing

Endocrinology in the time of COVID-19: Diagnosis and Management of Gestational Diabetes Mellitus.

Eur J Endocrinol 2020 May 1. Epub 2020 May 1.

H Teede, Monash Centre for Health Research and Implementation, Monash University, Melbourne, Australia.

The COVID-19 pandemic has required rapid transformation and adaptation of healthcare services. Women with gestational diabetes mellitus (GDM) are one of the largest high-risk groups accessing antenatal care. In reformulating the care offered to those with GDM, there is a need to balance the sometimes competing requirement of lowering the risk of direct viral transmission against the potential adverse impact of service changes. Read More

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http://dx.doi.org/10.1530/EJE-20-0401DOI Listing

The effects of empagliflozin versus metformin on endothelial microparticles in overweight/obese women with polycystic ovary syndrome.

Endocr Connect 2020 May 1. Epub 2020 May 1.

T Sathyapalan, Hull York Medical School, University of Hull, Hull, HU32RW, United Kingdom of Great Britain and Northern Ireland.

Context: Endothelial microparticles (EMPs) are novel, surrogate biomarkers of endothelial function and have been shown to be elevated in women with polycystic ovary syndrome (PCOS). It remains poorly understood how pharmacological options for managing PCOS affect EMP levels.

Objective: To characterise and compare the effects of empagliflozin vs. Read More

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http://dx.doi.org/10.1530/EC-20-0173DOI Listing

Health-related quality of life in neuroendocrine neoplasms: a critical review.

Endocr Relat Cancer 2020 May 1. Epub 2020 May 1.

J Ramage, Neuroendocrine Tumour Unit, ENETS Centre of Excellence, Institute of Liver Studies, King's College Hospital, London, United Kingdom of Great Britain and Northern Ireland.

Incidence of neuroendocrine neoplasia (NEN) is increasing, as is use of health-related quality of life (HRQoL) measurement in clinical trials. Following development of validated questionnaires, health-related quality of life is widely used to assess outcomes. This review is intended for healthcare professionals and is based on a selection of data published in the last decade. Read More

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http://dx.doi.org/10.1530/ERC-20-0066DOI Listing

Performance declines are accelerated in the oldest-old track and field athletes 80 to 94 years of age.

Rejuvenation Res 2020 May 25. Epub 2020 May 25.

Manchester Metropolitan University, 5289, Research Centre for Musculoskeletal Science & Sports Medicine, Manchester, Greater Manchester, United Kingdom of Great Britain and Northern Ireland;

Physical performance declines with age, even in exercising, healthy individuals without major illnesses or orthopaedic issues. The rate of performance decline is often reported to accelerate after the age of 70 years, but almost no data are available on performance in the fittest oldest-old. To assess their rate of decline in performance, the biggest dataset of track and field athletes ≥80 years (1567 results) ever published was generated for different disciplines from German athletics Federations including 1997-2019. Read More

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http://dx.doi.org/10.1089/rej.2020.2337DOI Listing

Cross-sectional study of British wild deer for evidence of Schmallenberg virus infection.

Vet Rec 2020 May 23. Epub 2020 May 23.

Institute of Infection and Global Health, University of Liverpool, Neston, UK

Background: Schmallenberg virus (SBV) is an orthobunyavirus, carried by biting midges, that causes reproductive problems in adult ruminants when infected during their gestation period. SBV was first detected in ruminants in the UK in 2011/2012 and then again in 2016. The reason behind the 2016 re-emergence of SBV is unknown, but one possibility is that it can be maintained in wildlife, such as deer. Read More

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http://dx.doi.org/10.1136/vr.105869DOI Listing

Oral healthcare workforce planning in post-Brexit Britain.

Authors:
Kenneth A Eaton

Br Dent J 2020 May;228(10):750-752

Visiting Professor, University College London, Honorary Professor University of Kent, Adviser to the Council of European Chief Dental Officers, UK.

The terms of the United Kingdom's (UK's) departure from the European Union (EU) are currently being negotiated. It is therefore uncertain exactly what effect they will have on planning the UK's oral healthcare workforce. Nevertheless, as 16% of dentists currently registered with the Genral Dental Council (GDC) have migrated to the UK from EU countries, this factor must be taken into consideration by workforce planners. Read More

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http://dx.doi.org/10.1038/s41415-020-1579-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243224PMC