Brief Bioinform 2017 Aug 18. Epub 2017 Aug 18.
Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA.
DNA methylation plays an essential role in cancer. Differential variability (DV) in cancer was recently observed that contributes to cancer heterogeneity and has been shown to be crucial in detecting epigenetic field defects, DNA methylation alterations happening early in carcinogenesis. As neighboring CpG sites are highly correlated, here, we present a new method to detect differentially methylated regions (DMRs) that uses combined signals from differential methylation and DV between sample groups. Read More