158,321 results match your criteria Brief Treatment and Crisis Intervention [Journal]


Employing pain and mindfulness to understand consciousness: a symbiotic relationship.

Curr Opin Psychol 2019 Jan 9;28:192-197. Epub 2019 Jan 9.

University of California San Diego, Department of Anesthesiology, 9500 Gillman Drive, MC0719, La Jolla, CA 92093, USA; Wake Forest School of Medicine, Department of Neurobiology and Anatomy, 1 Medical Center Boulevard, Winston-Salem, 27157, NC, USA. Electronic address:

Consciousness, defined here as the quality of awareness of self and the corresponding sensory environment, is considered to be one of most enigmatic and contentious areas of scholarly dissection and investigation. The subjective experience of pain is constructed and modulated by a myriad of sensory, cognitive and affective dimensions. Thus, the study of pain can provide many inroads to a concept like consciousness that the traditional sense modalities do not. Read More

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http://dx.doi.org/10.1016/j.copsyc.2018.12.025DOI Listing
January 2019

Brief report: Longitudinal associations between physical activity, sleep disturbance and depressive symptoms in adolescent girls.

J Adolesc 2019 Feb 15;72:37-41. Epub 2019 Feb 15.

University of Tartu, Faculty of Medicine, Institute of Sport Sciences and Physiotherapy, Estonia. Electronic address:

Introduction: Physical activity (PA) and sleep disturbances (SD) are related with depressive symptoms in adults. However, evidence that PA and SD are prospectively associated with depression is mixed. The aim of this study was to examine longitudinal and bidirectional associations between PA, SD and depressive symptoms in adolescent girls. Read More

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http://dx.doi.org/10.1016/j.adolescence.2019.02.003DOI Listing
February 2019

Xenogeneic Regulation of the Bacterial Transcription Machinery.

J Mol Biol 2019 Feb 15. Epub 2019 Feb 15.

MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, SW7 2AZ, UK. Electronic address:

The parasitic life cycle of viruses involves the obligatory subversion of the host's macromolecular processes for efficient viral progeny production. Viruses that infect bacteria, bacteriophages (phages), are no exception and have evolved sophisticated ways to control essential biosynthetic machineries of their bacterial prey to benefit phage development. The xenogeneic regulation of bacterial cell function is a poorly understood area of bacteriology. Read More

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http://dx.doi.org/10.1016/j.jmb.2019.02.008DOI Listing
February 2019

Measuring eating motives in older adults with and without functional impairments with The Eating Motivation Survey (TEMS).

Appetite 2019 Feb 15. Epub 2019 Feb 15.

Friedrich-Alexander-University of Erlangen-Nürnberg, Institute for Biomedicine of Aging, Kobergerstraße 60, 90408, Nürnberg, Germany.

Gaining a better understanding which motives play a role in daily eating is crucial in order to develop personalized interventions promoting adequate diet. The Eating Motivation Survey (TEMS) is a comprehensive tool to assess manifold reasons for eating but has not been specifically applied in an older sample including very old persons and persons differing in functional status. Therefore, the first step of the study was to investigate whether the basic motives of TEMS are consistent in an older sample and comparable across older adults with and without functional impairments. Read More

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http://dx.doi.org/10.1016/j.appet.2019.01.024DOI Listing
February 2019

Signaling characteristics and functional regulation of delta opioid-kappa opioid receptor (DOP-KOP) heteromers in peripheral sensory neurons.

Neuropharmacology 2019 Feb 15. Epub 2019 Feb 15.

Department of Pharmacology, The University of Texas Health San Antonio, 7703 Floyd Curl Drive, San Antonio, TX, 78229-3900, USA. Electronic address:

Receptor heteromers often display distinct pharmacological and functional properties compared to the individual receptor constituents. In this study, we compared the properties of the DOP-KOP heteromer agonist, 6'-guanidinonaltrindole (6'-GNTI), with agonists for DOP ([D-Pen2,5]-enkephalin [DPDPE]) and KOP (U50488) in peripheral sensory neurons in culture and in vivo. In primary cultures, all three agonists inhibited PGE-stimulated cAMP accumulation as well as activated extracellular signal-regulated kinase 1/2 (ERK) with similar efficacy. Read More

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http://dx.doi.org/10.1016/j.neuropharm.2019.02.019DOI Listing
February 2019

Network-based methods for predicting essential genes or proteins: a survey.

Brief Bioinform 2019 Feb 18. Epub 2019 Feb 18.

School of Computer Science and Engineering, Central South University, Changsha, Hunan, China.

Genes that are thought to be critical for the survival of organisms or cells are called essential genes. The prediction of essential genes and their products (essential proteins) is of great value in exploring the mechanism of complex diseases, the study of the minimal required genome for living cells and the development of new drug targets. As laboratory methods are often complicated, costly and time-consuming, a great many of computational methods have been proposed to identify essential genes/proteins from the perspective of the network level with the in-depth understanding of network biology and the rapid development of biotechnologies. Read More

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http://dx.doi.org/10.1093/bib/bbz017DOI Listing
February 2019

A consolidated account of electrochemical determination of band structure parameters in II-VI semiconductor quantum dots: a tutorial review.

Phys Chem Chem Phys 2019 Feb 18. Epub 2019 Feb 18.

Department of Chemistry, IIT Delhi, New Delhi 110016, India.

Probing absolute electronic energy levels in semiconductor quantum dots (Q-dots) is crucial for engineering their electronic band structure and hence for precise design of composite nano-structure based devices. The use of electrochemistry has allowed us to investigate size, shape and composition dependent band structure parameters viz. the conduction band edge, valence band edge & quasi-particle gap and to establish novel charge induced phenomena in colloidal semiconductor Q-dots. Read More

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http://dx.doi.org/10.1039/c8cp06847jDOI Listing
February 2019

A case report of acute rheumatic fever and a brief review of the literature.

Arch Med Sci Atheroscler Dis 2018 28;3:e80-e82. Epub 2018 Jun 28.

Department of Pediatrics, Shanghai Xin Hua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

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http://dx.doi.org/10.5114/amsad.2018.76825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374571PMC

A web-based intervention for carers of individuals with anorexia nervosa (We Can): Trial protocol of a randomised controlled trial investigating the effectiveness of different levels of support.

Internet Interv 2019 Apr 22;16:76-85. Epub 2018 Feb 22.

King's College London, Institute of Psychiatry, Psychology and Neuroscience, Section of Eating Disorders, PO Box 59, 16, De Crespigny Park, London, SE5 8AF, UK.

Background: Anorexia nervosa (AN) is a life-threatening mental disorder that is associated with substantial caregiver burden. Carers of individuals with AN report high levels of distress and self-blame, and insufficient knowledge to help their loved ones. However, carers can have a very important role to play in aiding recovery from AN, and are often highly motivated to assist in the treatment process. Read More

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http://dx.doi.org/10.1016/j.invent.2018.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364327PMC

The effect of enzyme replacement therapy on clinical outcomes in male patients with Fabry disease: A systematic literature review by a European panel of experts.

Mol Genet Metab Rep 2019 Jun 6;19:100454. Epub 2019 Feb 6.

Department of Paediatrics, University of Torino, Torino, Italy.

Background: Enzyme replacement therapy (ERT) with recombinant human α-galactosidase has been available for the treatment of Fabry disease since 2001 in Europe and 2003 in the USA. Treatment outcomes with ERT are dependent on baseline patient characteristics, and published data are derived from heterogeneous study populations.

Methods: We conducted a comprehensive systematic literature review of all original articles on ERT in the treatment of Fabry disease published up until January 2017. Read More

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http://dx.doi.org/10.1016/j.ymgmr.2019.100454DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365982PMC

Current progress and questions in germline genetics of prostate cancer.

Asian J Urol 2019 Jan 2;6(1):3-9. Epub 2018 Nov 2.

North Shore University Health System, Research Institute, Evanston, IL, USA.

Dramatic progress has been made in the area of germline genetics of prostate cancer (PCa) in the past decade. Both common and rare genetic variants with effects on risk ranging from barely detectable to outright practice-changing have been identified. For men with high risk PCa, the application of genetic testing for inherited pathogenic mutations is becoming standard of care. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363602PMC
January 2019

Caecal Epiploic Appendagitis Masquerading Clinically as an Acute Appendicitis: A Case Report and Brief Literature Review.

Case Rep Surg 2019 15;2019:6508642. Epub 2019 Jan 15.

Department of Radiology, Midland Regional Hospital Mullingar, Longford Road, Mullingar, Co-Westmeath, Ireland.

A 46-year-old female presented to our emergency department (ED) with a 2-day history of right lower abdominal pain which was associated with nausea and anorexia. Abdominal examination revealed tenderness in the right iliac fossa (RIF) with rebound tenderness and a localized guarding. Urine dipstick was normal, and the pregnancy test was negative. Read More

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http://dx.doi.org/10.1155/2019/6508642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350580PMC
January 2019

Brief behavioural intervention, delivered as standard care, to support physical activity engagement in men with prostate cancer: a pilot study protocol.

BMJ Open Sport Exerc Med 2018 17;4(1):e000469. Epub 2018 Dec 17.

Translational Oncology and Urology Research, King's College London, London, UK.

Introduction: Physical activity is beneficial to men with prostate cancer, but there remain barriers to fulfilling the potential of National Health Service trusts to support men with prostate cancer to be physically active. This article describes protocols for two pilot studies, each conducted in a different setting, designed to assess the potential of a behavioural intervention to affect patients' motivation to exercise. The intervention is theory based and inspired by recent empirical observations. Read More

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http://dx.doi.org/10.1136/bmjsem-2018-000469DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350748PMC
December 2018

The short inventory of grazing (SIG): development and validation of a new brief measure of a common eating behaviour with a compulsive dimension.

J Eat Disord 2019 7;7. Epub 2019 Feb 7.

1School of Medicine, Western Sydney University, Locked Bag 1797, Penrith, 2751 NSW Australia.

Background: Grazing, the repetitious and unplanned eating of small amounts of food with or without a sense of loss of control (LOC), is an eating pattern of recent interest which is highly prevalent in eating disorders and obesity. The current study aimed to (1) assess psychometric properties of a short inventory of grazing (SIG), consisting of a "grazing in general" item and a "compulsive/LOC grazing" item and (2) examine associations between compulsive and non-compulsive grazing and body mass index (BMI), eating disorder psychopathology, distress and health-related quality of life.

Methods: Participants recruited from a university and the community ( = 227; 75. Read More

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http://dx.doi.org/10.1186/s40337-019-0234-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366119PMC
February 2019

Implementation of a point-of-care ultrasound skills practicum for hospitalists.

Ultrasound 2019 Feb 25;27(1):38-44. Epub 2018 Jul 25.

Division of Pulmonary, Critical Care, Allergy, and Occupational Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Introduction: Point-of-care ultrasound is recognized as a safe and valuable diagnostic tool for patient evaluation. Hospitalists are prime candidates for advancing the point-of-care ultrasound field given their crucial role in inpatient medicine. Despite this, there is a notable lack of evidence-based ultrasound training for hospitalists. Read More

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http://dx.doi.org/10.1177/1742271X18791317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362537PMC
February 2019

LIFE QUALITY EVALUATION USING "TIME TRADE OFF" METHOD FOR RHEUMATOID HANDS.

Acta Ortop Bras 2018 ;26(6):374-378

Hand and Microsurgery Group, Institute of Orthopedics and Traumatology Medical School, Universidade de Sao Paulo, Hospital das Clinicas HCFMUSP, Sao Paulo, SP, Brazil.

Objective: Rheumatoid arthritis is a prevalent disease in the population (range 0.5% to 1%) and involves both orthopedic and rheumatologic treatment. The Time Trade-Off (TTO) technique, which determines the number of years the patient or the professional would be allowed before a successful procedure in terms of life expectancy and value of the procedure, has been gaining ground in clinical protocols. Read More

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http://dx.doi.org/10.1590/1413-785220182606199308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362677PMC
January 2018

Pain experiences and intrapersonal change among patients with chronic non-cancer pain after using a pain diary: a mixed-methods study.

J Pain Res 2019 23;12:477-487. Epub 2019 Jan 23.

Department of Anesthesia, Alan Edwards Pain Management Unit, McGill University, Montreal, QC, Canada.

Objective: Pain diaries are a valuable self-assessment tool; however, their use in chronic non-cancer pain has received limited attention. In this study, we examined the effect of pain diary use on pain intensity, interference, and intrapersonal change in patients with chronic non-cancer pain.

Method: A convergent mixed-methods design was used to prospectively evaluate a cohort of 72 patients. Read More

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http://dx.doi.org/10.2147/JPR.S186105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361316PMC
January 2019

Methods for Studying Gut Microbiota: A Primer for Physicians.

J Clin Exp Hepatol 2019 Jan-Feb;9(1):62-73. Epub 2018 May 4.

Biomedical Informatics Center, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India.

Human gastrointestinal tract contains a large variety of microbes, in particular bacteria. Studies in recent years have strongly suggested a role for these microbes, collectively referred to as gut microbiota, in the maintenance of homeostasis during health. In addition, alterations in gut microbiota have been reported in several diseases, including those related to the gastrointestinal tract and several systemic conditions, and are believed to play a pathogenetic role in at least some of these. Read More

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http://dx.doi.org/10.1016/j.jceh.2018.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363981PMC

Cognition and physical functioning in patients with schizophrenia: any role for vitamin D?

Nutr Neurosci 2019 Feb 17:1-9. Epub 2019 Feb 17.

a Psychiatric Hospital of the Cross , Jal Eddib , Lebanon.

Aim: The study's objective was to evaluate the relationship between vitamin D (VD) levels and cognitive performance in patients with schizophrenia.

Methods: A cross-sectional study, conducted between March and July 2016, recruited 196 patients with schizophrenia. The Brief Cognitive Rating Scale (BCRS) and the Morningside Rehabilitation Status Scale (MRSS) were used to measure the severity of cognitive impairment and the level of general functioning in psychiatric patients. Read More

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http://dx.doi.org/10.1080/1028415X.2019.1580830DOI Listing
February 2019

Recent Advances in the Development of Water Oxidation Electrocatalysts at Mild pH.

Small 2019 Feb 18:e1805103. Epub 2019 Feb 18.

Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu, 610054, Sichuan, China.

Developing anodic oxygen evolution reaction (OER) electrocatalysts with high catalytic activities is of great importance for effective water splitting. Compared with the water-oxidation electrocatalysts that are commonly utilized in alkaline conditions, the ones operating efficiently under neutral or near neutral conditions are more environmentally friendly with less corrosion issues. This review starts with a brief introduction of OER, the importance of OER in mild-pH media, as well as the fundamentals and performance parameters of OER electrocatalysts. Read More

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http://dx.doi.org/10.1002/smll.201805103DOI Listing
February 2019

High-dose Intravenous Immunoglobulin to Treat Spontaneous Heparin-induced Thrombocytopenia Syndrome.

J Thromb Haemost 2019 Feb 18. Epub 2019 Feb 18.

Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada.

Spontaneous HIT syndrome is an autoimmune HIT (aHIT) disorder characterized by thrombocytopenia, thrombosis, and HIT antibodies despite no proximate heparin exposure. For unknown reasons, many cases occur after total knee arthroplasty. A 52-year-old woman presented 12 days post-total knee replacement (aspirin thromboprophylaxis) with gastrointestinal bleeding (superior mesenteric vein thrombosis); the platelet count was 63 × 10 L . Read More

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http://dx.doi.org/10.1111/jth.14411DOI Listing
February 2019

Enhancing Electrocatalytic Water Splitting by Strain Engineering.

Adv Mater 2019 Feb 18:e1807001. Epub 2019 Feb 18.

School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore, 639798, Singapore.

Electrochemical water splitting driven by sustainable energy such as solar, wind, and tide is attracting ever-increasing attention for sustainable production of clean hydrogen fuel from water. Leveraging these advances requires efficient and earth-abundant electrocatalysts to accelerate the kinetically sluggish hydrogen and oxygen evolution reactions (HER and OER). A large number of advanced water-splitting electrocatalysts have been developed through recent understanding of the electrochemical nature and engineering approaches. Read More

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http://dx.doi.org/10.1002/adma.201807001DOI Listing
February 2019

High-Performance Materials for 3D Printing in Chemical Synthesis Applications.

Adv Mater 2019 Feb 18:e1805982. Epub 2019 Feb 18.

Institute of Microstructure Technology (IMT), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany.

3D printing has emerged as an enabling technology for miniaturization. High-precision printing techniques such as stereolithography are capable of printing microreactors and lab-on-a-chip devices for efficient parallelization of biological and biochemical reactions under reduced uptake of reactants. In the world of chemistry, however, up until now, miniaturization has played a minor role. Read More

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http://dx.doi.org/10.1002/adma.201805982DOI Listing
February 2019

Delivering blended bioinformatics training in resource-limited settings: a case study on the University of Khartoum H3ABioNet node.

Brief Bioinform 2019 Feb 15. Epub 2019 Feb 15.

Center for Bioinformatics and Systems Biology, Faculty of Science, University of Khartoum, Khartoum, Sudan.

Motivation: Delivering high-quality distance-based courses in resource-limited settings is a challenging task. Besides the needed infrastructure and expertise, effective delivery of a bioinformatics course could benefit from hands-on sessions, interactivity and problem-based learning approaches.

Results: In this article, we discuss the challenges and best practices in delivering bioinformatics training in resource-limited settings taking the example of hosting and running a multiple-delivery online course, Introduction to Bioinformatics, that was developed by the H3ABioNet Education and Training working group and delivered in 27 remote classrooms across Africa in 2017. Read More

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http://dx.doi.org/10.1093/bib/bbz004DOI Listing
February 2019

What do patients fear most about having oral surgery?

Quintessence Int 2019 ;50(3):204-207

Objective: Considerable emphasis has been placed on the fear that patients undergoing oral surgery have of the local anesthetic injection. However, other potential factors such as fear of pain during the operation, fear of the operation itself, and fear of postoperative pain are often not considered. The purpose of this study was to determine how patients rank their fear of these four factors. Read More

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http://dx.doi.org/10.3290/j.qi.a41919DOI Listing
January 2019

CT-Guided Percutaneous Gastrostomy without Preliminary Placement of a Nasogastric Tube.

J Vasc Interv Radiol 2019 Feb 14. Epub 2019 Feb 14.

Department of Interventional and Diagnostic Imaging, Cancer Center Antoine Lacassagne, Nice 06189, France. Electronic address:

Percutaneous radiologic gastrostomy (PRG) requires preliminary gastric inflation through a nasogastric tube (NGT) to safely perform gastric puncture. However, in case of pharyngeal or esophageal obstruction, NGT placement may be impossible even with a hydrophilic angiography catheter and wire. This brief report describes percutaneous computed tomography (CT)-guided gastrostomy with a 2-stick approach without nasogastric insufflation in 13 patients. Read More

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http://dx.doi.org/10.1016/j.jvir.2018.08.014DOI Listing
February 2019

Pain Characteristics and Pain Interference Among Patients Undergoing Open Cardiac Surgery.

J Perianesth Nurs 2019 Feb 14. Epub 2019 Feb 14.

Purpose: The aim of this study was to analyze postoperative pain severity, pain characteristics, and factors that affect pain for patients undergoing open cardiac surgery.

Design: A descriptive, cross-sectional study design was used.

Methods: This study was conducted on 70 patients who underwent open cardiac surgery at a state hospital in North Cyprus. Read More

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http://dx.doi.org/10.1016/j.jopan.2018.10.009DOI Listing
February 2019

Quality of life after total laryngectomy: evaluating the effect of socioeconomic status.

J Laryngol Otol 2019 Feb 18:1-6. Epub 2019 Feb 18.

Division of Otorhinolaryngology, Department of Surgery,University of Cape Town,South Africa.

Objective: Total laryngectomy is considered the primary treatment modality for advanced laryngeal carcinoma. This study assessed the quality of life in patients after total laryngectomy, and ascertained whether quality of life is affected by socioeconomic status.

Method: Forty-seven patients (20 state- and 27 private-sector) who underwent total laryngectomy between 1998 and 2014 responded to the University of Washington Quality of Life Questionnaire, the Voice-Related Quality of Life Questionnaire and the Brief Illness Perception Questionnaire. Read More

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http://dx.doi.org/10.1017/S0022215119000215DOI Listing
February 2019

Review: Microwave assisted extraction of phytochemicals an efficient and modern approach for botanicals and pharmaceuticals.

Pak J Pharm Sci 2019 Jan;32(1):223-230

Dept. of Botany, Lahore College for Women University, Lahore, Pakistan.

The final quality of pharmaceutically active herbal preparation is significantly contributed by extraction procedures. Hence in the last decade Microwave assisted extraction (MAE) has been introduced. This is an efficient and modern tool with multiple benefits as compared to the traditional methods of extraction. Read More

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January 2019

Spiritual struggles and mental health outcomes in a spiritually integrated inpatient program.

J Affect Disord 2019 Feb 6;249:127-135. Epub 2019 Feb 6.

Pine Rest Christian Mental Health Services, Grand Rapids, MI, United States.

Background: Persons contending with serious mental health difficulties often experience struggles with religious faith and/or spirituality that may also demand clinical attention. However, research has not examined the relative importance of specific forms of spiritual struggles in mental health status or treatment outcomes of psychiatric patients.

Methods: Focusing on 217 adults who completed a spiritually integrated inpatient program, this study examined (1) which struggles in Exline et al. Read More

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http://dx.doi.org/10.1016/j.jad.2019.02.012DOI Listing
February 2019

Circulating lncRNA BC030099 Increases in Preeclampsia Patients.

Mol Ther Nucleic Acids 2019 Feb 1;14:562-566. Epub 2019 Feb 1.

Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Harbin Medical University, Harbin, China. Electronic address:

Long noncoding RNAs (lncRNAs) have increasingly been shown to be important biological regulators involved in numerous diseases. Further, increasing evidence demonstrates that circulating lncRNAs can be used as diagnostic biomarkers. Therefore, the purpose of this study was to evaluate the potential for circulating lncRNAs as novel biomarkers for the diagnosis of preeclampsia. Read More

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http://dx.doi.org/10.1016/j.omtn.2019.01.011DOI Listing
February 2019

Liver Transplant Recipients Older Than 60 Years Show Executive and Memory Function Improvement Comparable to Younger Recipients.

Psychosomatics 2019 Jan 23. Epub 2019 Jan 23.

Department of Psychiatry & Psychology, Mayo Clinic, Jacksonville, FL; Mayo Clinic Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery, Mayo Clinic, Jacksonville, FL. Electronic address:

Background: Increasing numbers of patients over the age of 60 are undergoing liver transplantation.

Objective: We sought to determine whether age or clinical morbidities were associated with pre- and post-transplant executive and memory performance using the Brief Test of Adult Cognition by Telephone (BTACT).

Methods: Participants included 36 recipients with n = 20 in the older group (>60 y) and n = 16 in the younger group (≤60 years). Read More

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http://dx.doi.org/10.1016/j.psym.2019.01.008DOI Listing
January 2019

Clinical and genetic analysis of children with a dual diagnosis of Tourette syndrome and autism spectrum disorder.

J Psychiatr Res 2019 Feb 7;111:145-153. Epub 2019 Feb 7.

Department of Medical Genetics, University of Alberta, Edmonton, AB, Canada. Electronic address:

Gilles de la Tourette Syndrome (TS) is a neurodevelopmental disorder that causes children to make repeated, brief involuntary movements or sounds. TS can be co-morbid with other neurodevelopmental disorders, including autism spectrum disorder (ASD). Clusters of biologically related genes have been associated with neurodevelopmental disorders, suggesting shared pathologies. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.01.023DOI Listing
February 2019

Change in Mental Health Stigma After a Brief Intervention Among Internally Displaced Persons in Central Sudan.

Community Ment Health J 2019 Feb 15. Epub 2019 Feb 15.

Department of Public Health, Innlandet University Collage, Elverum, Norway.

Stigmatizing attitudes towards people with mental illness is a worldwide phenomenon, This Longitudinal study aimed to determine the level of stigma, among the internal displaced persons in central Sudan and explore possible changes in stigma associated with an intervention. 1549 persons were interviewed using standardized stigma attitude tools. The study reveled high level of stigma among our respondents and there was no significant difference in attitudes towards mental illness observed after the intervention. Read More

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http://dx.doi.org/10.1007/s10597-019-00375-yDOI Listing
February 2019

Binding identity and orientation in object recognition.

Atten Percept Psychophys 2019 Feb 15. Epub 2019 Feb 15.

School of Psychology, University of Auckland, Auckland, New Zealand.

We tested whether an object's orientation is inherently bound to its identity in a holistic view-based representation at the early stages of visual identification, or whether identity and orientation are represented separately. Observers saw brief and masked stimulus sequences containing two rotated objects. They had to detect if a previously cued object was present in the sequence and report its orientation. Read More

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http://dx.doi.org/10.3758/s13414-019-01677-9DOI Listing
February 2019

Enhancing Curcumin Oral Bioavailability Through Nanoformulations.

Eur J Drug Metab Pharmacokinet 2019 Feb 15. Epub 2019 Feb 15.

Institute of Chemical Technology, Mumbai, India.

Curcumin is a promising therapeutic agent that exhibits manifold therapeutic activities. However, it is challenging to study curcumin as it exhibits poor aqueous solubility and low permeability and it is a substrate for P-glycoprotein (P-gp). It is readily metabolized in the body, but many active metabolites of curcumin have been identified that could also be exploited for therapy. Read More

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http://dx.doi.org/10.1007/s13318-019-00545-zDOI Listing
February 2019

Energy drinks in children and adolescents: demographic data and immediate effects.

Eur J Pediatr 2019 Feb 15. Epub 2019 Feb 15.

Pediatric Department, Saint Vincent De Paul Hospital, Faculty of Medicine, Bar-Ilan University, PO box 50294, 16102, Nazareth, Israel.

Energy drinks consumption has become increasingly common in the last few years, despite evidence associating these products with vast adverse health effects. This led us to explore the phenomenon of energy drinks consumption in adolescents in the Israeli Arab population of the Nazareth area (Northern Israel), examining their awareness of risks associated with consumption of energy drinks, investigating their immediate effects on the body. Our study revealed that the consumption of energy drinks is very common in adolescents of both sexes, though more common in boys. Read More

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http://dx.doi.org/10.1007/s00431-019-03342-7DOI Listing
February 2019

LXRα promotes cell metastasis by regulating the NLRP3 inflammasome in renal cell carcinoma.

Cell Death Dis 2019 Feb 15;10(3):159. Epub 2019 Feb 15.

Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Notwithstanding the researches on biomarkers and targeted therapies in renal cell carcinomas (RCC) have made progress in the last decades, the application of the biomarkers and targeted therapy agents for RCC in clinic are restricted because of their limitation or side effects. Liver X receptors (LXRs) and the NLRP3 inflammasome have been the research hotspots in recent years. In our study, we integrated bioinformatics analysis, molecular biology experiments and biological function experiments to study the roles of LXRα and the NLRP3 inflammasome in RCC. Read More

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http://dx.doi.org/10.1038/s41419-019-1345-3DOI Listing
February 2019
5.014 Impact Factor

[Application Status and Development Trends of Medical Proton and Heavy Ion Accelerators].

Zhongguo Yi Liao Qi Xie Za Zhi 2019 Jan;43(1):37-42

School of Mechanical and Electronical Engineering, Lanzhou University of Technology, Lanzhou, 730050.

Cancer therapy with accelerated proton or heavy ion beam is the most advanced radiotherapy technology, which is recognized by the international community at present. It is of great practical significance to study the medical proton and heavy ion accelerators and the radiotherapy technology, in order to promote the development of the advanced medical radiotherapy equipments and improve the quality of life of cancer patients in China. After a brief overview of cancer therapy with proton and heavy ion beam, this paper summarized and analyzed the application status of medical proton accelerators and medical heavy ion accelerators at home and abroad, and finally put forward the future development trends of medical proton and heavy ion accelerators and the radiotherapy technology, it can provide a reference for the progress and development strategies of the advanced radiotherapy equipments in China. Read More

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http://dx.doi.org/10.3969/j.issn.1671-7104.2019.01.010DOI Listing
January 2019

[Research Progress of Dynamic Musculoskeletal Ultrasound Image Processing].

Zhongguo Yi Liao Qi Xie Za Zhi 2019 Jan;43(1):32-36

School of Biomedical Engineering, Shenzhen University, Shenzhen, 518060.

Muscle is one of the most important tissues of human body, which is distributed around various organs and bones. Skeletal muscle plays an important role in human activities and its functional changes are closely related to its own morphological structure. The study of the relationship between musculoskeletal structure and function can help us to understand the physiology basics of force and to guide clinical practices. Read More

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http://dx.doi.org/10.3969/j.issn.1671-7104.2019.01.009DOI Listing
January 2019
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Human scalp hair: Modulation by various factors and hormones do estrogens inhibit or stimulate-A perplexing perspective.

Authors:
Edwin D Lephart

J Cosmet Dermatol 2019 Feb 15. Epub 2019 Feb 15.

Department of Physiology and Developmental Biology and The Neuroscience Center, College of Life Science, Brigham Young University, Provo, Utah.

Several journal reports, reviews, and commentaries over the last 20-25 years have pointed out the controversy attached to 17β-estradiol's inhibitory or stimulatory influence on hair follicle growth/cycling citing rodent (murine) and human results. While 17β-estradiol is the most potent sex steroid hormone in the body and has almost equal affinity for estrogen receptor (ER) alpha (α) and beta (β), there appears to be specific ER-mediated effects on scalp hair follicles/growth, etc. Additionally, the newly discovered G protein-coupled estrogen receptor (GPR30 or GPER) and the orphan receptor, estrogen-related receptor (ERR) gamma (γ), in skin and other tissue sites have potential impacts of how estrogens via these receptors may alter scalp hair characteristics, but this remains to be elucidated. Read More

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http://dx.doi.org/10.1111/jocd.12888DOI Listing
February 2019

A Mechanistic Understanding of Polysorbate 80 Oxidation in Histidine and Citrate Buffer Systems-Part 2.

PDA J Pharm Sci Technol 2019 Feb 15. Epub 2019 Feb 15.

Eli Lilly and Company.

In our previous published work, we reported rapid Polysorbate80 (PS80) oxidation in histidine buffer after brief stainless steel exposure and the ability of citrate and EDTA to prevent this oxidation. The focus of our current study was to mechanistically understand PS80 oxidation by studying the impact of temperature, light, stainless steel and the role of citrate and EDTA. Additionally, PS80 oxidation was studied in three different buffer sytems: histidine, citrate, and phosphate. Read More

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http://dx.doi.org/10.5731/pdajpst.2018.009639DOI Listing
February 2019

Randomised controlled trial of real-time feedback and brief coaching to reduce indoor smoking.

Tob Control 2019 Feb 15. Epub 2019 Feb 15.

Center for Behavioral Epidemiology and Community Health, Graduate School of Public Health, San Diego State University, San Diego, California, USA.

Background: Previous secondhand smoke (SHS) reduction interventions have provided only feedback on reported smoking behaviour, such as coaching, or presenting results from child cotinine assays or air particle counters.

Design: This SHS reduction trial assigned families at random to brief coaching and continuous real-time feedback (intervention) or measurement-only (control) groups.

Participants: We enrolled 298 families with a resident tobacco smoker and a child under age 14. Read More

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http://dx.doi.org/10.1136/tobaccocontrol-2018-054717DOI Listing
February 2019

Patient-reported outcomes following enzalutamide or placebo in men with non-metastatic, castration-resistant prostate cancer (PROSPER): a multicentre, randomised, double-blind, phase 3 trial.

Lancet Oncol 2019 Feb 12. Epub 2019 Feb 12.

University College London Cancer Institute, London, UK.

Background: In the PROSPER trial, enzalutamide significantly improved metastasis-free survival in patients with non-metastatic, castration-resistant prostate cancer. Here, we report the results of patient-reported outcomes of this study.

Methods: In the randomised, double-blind, placebo-controlled, phase 3 PROSPER trial, done at 254 study sites worldwide, patients aged 18 years or older with non-metastatic, castration-resistant prostate cancer and a prostate-specific antigen doubling time of up to 10 months were randomly assigned (2:1) via an interactive voice web recognition system to receive oral enzalutamide (160 mg per day) or placebo. Read More

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http://dx.doi.org/10.1016/S1470-2045(18)30898-2DOI Listing
February 2019

An RCT of brief cognitive therapy versus treatment as usual in patients with non-cardiac chest pain.

Int J Cardiol 2019 Feb 5. Epub 2019 Feb 5.

Department of Medicine, University of Otago, Christchurch, New Zealand.

Background: Non-cardiac chest pain (NCCP) is a common reason for presenting to an emergency department (ED). Many patients re-present with similar symptoms despite reassurance.

Objective: To investigate the clinical value of a brief cognitive behavioural treatment (CBT) in reducing re-presentations of patients who present with NCCP. Read More

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http://dx.doi.org/10.1016/j.ijcard.2019.01.067DOI Listing
February 2019

Functional asymmetry of thalamocortical networks in subjects at ultra-high risk for psychosis and first-episode schizophrenia.

Eur Neuropsychopharmacol 2019 Feb 12. Epub 2019 Feb 12.

Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China. Electronic address:

Disrupted functional asymmetry has been implicated in schizophrenia. However, it remains unknown whether disrupted functional asymmetry originates from intra-hemispheric and/or inter-hemispheric functional connectivity (FC) in the patients, and whether it starts at very early stage of psychosis. Seventy-six patients with first-episode, drug-naive schizophrenia, 74 subjects at ultra-high risk for psychosis (UHR), and 71 healthy controls underwent resting-state functional magnetic resonance imaging. Read More

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http://dx.doi.org/10.1016/j.euroneuro.2019.02.006DOI Listing
February 2019

Goals-of-Care Conversations for Older Adults With Serious Illness in the Emergency Department: Challenges and Opportunities.

Ann Emerg Med 2019 Feb 12. Epub 2019 Feb 12.

Division of Palliative Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA; Department of Psychosocial Oncology and Palliative Care, Dana-Farber Cancer Institute, Boston, MA; Department of Medicine, Division of Palliative Medicine, Brigham and Women's Hospital, Boston, MA.

During the last 6 months of life, 75% of older adults with preexisting serious illness, such as advanced heart failure, lung disease, and cancer, visit the emergency department (ED). ED visits often mark an inflection point in these patients' illness trajectories, signaling a more rapid rate of decline. Although most patients are there seeking care for acute issues, many of them have priorities other than to simply live as long as possible; yet without discussion of preferences for treatment, they are at risk of receiving care not aligned with their goals. Read More

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http://dx.doi.org/10.1016/j.annemergmed.2019.01.003DOI Listing
February 2019

Potential for Long-Term Benefit of Cognitive Behavioral Therapy as an Adjunct Treatment for Men with Erectile Dysfunction.

J Sex Med 2019 Feb;16(2):300-306

Department of Psychology, Valparaiso University, Valparaiso, IN, USA. Electronic address:

Introduction: Psychosexual counseling may enhance sexual performance outcomes in men with erectile dysfunction (ED) treated with a phosphodiesterase type 5 (PDE5) inhibitor.

Aim: To determine the potential long-term effects of cognitive behavioral therapy (CBT) on Pakistani men with ED who had undergone treatment with a PDE5 inhibitor (PDE5i).

Methods: In a 15-18-month follow-up, we reassessed a subsample of 20 men who had been treated with either PDE5is (monotherapy group) or CBT + PDE5i (combined group) on 2 dimensions: sexual functioning and mental health functioning. Read More

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http://dx.doi.org/10.1016/j.jsxm.2018.12.014DOI Listing
February 2019

A Multi-Campus Pilot Feasibility Evaluation of a Bystander-Based Sexual Violence Prevention Program: Exploring the Influence of Drinking Behaviors on Bystander Behavior.

J Interpers Violence 2019 Feb 15:886260519829286. Epub 2019 Feb 15.

4 College of Charleston, SC, USA.

Researchers and policy makers are devoting considerable attention to the development and evaluation of sexual violence prevention programming for college campuses. Although several programs have been developed over the last decade, questions remain about whether programs can be effectively implemented across diverse campuses and whether individual-level factors like alcohol use moderate program effectiveness. The purpose of this pilot study was to evaluate the impact of a brief, sexual violence prevention program-The Men's Program-on two diverse campuses. Read More

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http://dx.doi.org/10.1177/0886260519829286DOI Listing
February 2019
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