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Psychiatry Res 2019 Mar 26;276:45-55. Epub 2019 Mar 26.

Autism Clinic for Translational Research, Brain and Mind Centre, Central Clinical School, Faculty of Medicine, University of Sydney, Camperdown, Sydney, NSW 2050 Australia. Electronic address:

Social functioning is an important component of mental disorders for assessment and treatment. There is no recognised self-report instrument to measure social functioning across disorders where social impairment is significant. The Social Functioning Scale (SFS) has, however, been used to assess social functioning in psychotic disorders, including Schizophrenia and Early Psychosis. Read More

J Clin Med 2019 Apr 18;8(4). Epub 2019 Apr 18.

Division of Pulmonology, Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Alexandra Hospital, 11528 Athens, Greece.

Patients with serious psychiatric diseases (major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia and psychotic disorder) often complain about sleepiness during the day, fatigue, low energy, concentration problems, and insomnia; unfortunately, many of these symptoms are also frequent in patients with Obstructive Sleep Apnea (OSA). However, existing data about the clinical appearance of OSA in Psychiatric Disease are generally missing. The aim of our study was a detailed and focused evaluation of OSA in Psychiatric Disease, in terms of symptoms, comorbidities, clinical characteristics, daytime respiratory function, and overnight polysomnography data. Read More

Int J Med Mushrooms 2019 ;21(4):323-330

School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, 302017, Jaipur, India.

Haloperidol-induced catalepsy is an animal model of a psychotic disorder that may be associated with neurodegeneration and free radical damage. Auricularia polytricha is effective in both prevention and treatment of numerous types of neurological disorders. In the present study, anticataleptic activity of aqueous extract of A polytricha (AEAP) at different doses (400 and 600 mg/kg, respectively, p. Read More

Front Genet 2019 3;10:258. Epub 2019 Apr 3.

Shanghai Mental Health Center, School of Biomedical Engineering, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Neurodevelopmental and psychiatric disorders are a highly disabling and heterogeneous group of developmental and mental disorders, resulting from complex interactions of genetic and environmental risk factors. The nature of multifactorial traits and the presence of comorbidity and polygenicity in these disorders present challenges in both disease risk identification and clinical diagnoses. The genetic component has been firmly established, but the identification of all the causative variants remains elusive. Read More

CNS Drugs 2019 Apr 16. Epub 2019 Apr 16.

Psychotic Disorders Program, UMASS Memorial Medical Center, Biotech One, Suite 100, 365 Plantation Street, Worcester, MA, 01605, USA.

A growing body of literature has elucidated the involvement of the central renin-angiotensin system (RAS) in various neuropsychiatric diseases. While consensus on the exact mechanism of the central RAS in schizophrenia pathophysiology does not currently exist, increasing evidence reveals promise in harnessing the therapeutic potential of RAS modulation in the treatment of schizophrenia. In this review, we examine how the central RAS affects inflammation, glutamate, dopamine, gamma-aminobutyric acid (GABA), and peroxisome proliferator-activated receptor (PPAR)-γ, all of which are associated with schizophrenia etiology. Read More

Neuropsychobiology 2019 Apr 16:1-4. Epub 2019 Apr 16.

Translational Research Center, University Hospital of Psychiatry, University of Bern, Bern, Switzerland.

Nutrients 2019 Apr 2;11(4). Epub 2019 Apr 2.

Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Department of Neurosciences and Mental Health, 20122 Milan, Italy.

Cognitive impairment is strongly associated with functional outcomes in psychiatric patients. Involvement of -3 long chain polyunsaturated fatty acid (-3 LC-PUFA), in particular docosahexaenoic acid (DHA), in brain functions is largely documented. DHA is incorporated into membrane phospholipids as structural component, especially in the central nervous system where it also has important functional effects. Read More

Indian J Psychol Med 2019 Mar-Apr;41(2):138-143

Department of Psychiatry, National Institute of Mental Health and Neuro Sciences, Bengaluru, Karnataka, India.

Background: Forensic patients are often admitted to psychiatric hospitals without any details of illness or treatment. They pose a unique challenge for clinical services in the context of diagnosis, management, and particularly legal issues.

Materials And Methods: We conducted a retrospective chart review using a structured data-extraction tool. Read More

Rev Colomb Psiquiatr 2019 Apr - Jun;48(2):127-130. Epub 2017 Dec 11.

Unidad de Neurología, Instituto Nacional de Neurología y Neurocirugía, Ciudad de México, México.

Anti-N-methyl-D-Aspartate receptor (NMDAr) encephalitis is a recently described clinical entity with an increasing number of reported cases. Psychiatric symptoms in the early stages of the disease constitute a diagnostic challenge for the treating physician. We present two clinical cases: clinical case 1, a 26-year-old man, and clinical case 2, an 18-year-old man; both presented with a first episode of psychosis and were hospitalized as psychiatric disorders. Read More

Cult Med Psychiatry 2019 Apr 12. Epub 2019 Apr 12.

Department of Psychiatry, The University of Toronto, Toronto, Canada.

Alterations in self-experience are increasingly attended to as relevant and important aspects of schizophrenia, and psychosis more broadly, through a burgeoning self-disorders (SD) literature. At the same time, issues of self, subject, and subjectivity within schizophrenia-spectrum illnesses have also gained attention from researchers across the social sciences and humanities, and from ethnographic research especially. This paper examines the subjective experience of disruptions in self-identity within a cohort of first episode psychosis (FEP) service users, critically engaging with the SD literature and bringing it into conversation with social sciences and humanities scholarship on self and schizophrenia. Read More

Evid Based Ment Health 2019 Apr 12. Epub 2019 Apr 12.

Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, UK.

Objective: Mendelian randomisation (MR) is a technique that aims to assess causal effects of exposures on disease outcomes. The paper aims to present the main assumptions that underlie MR, the statistical methods used to estimate causal effects and how to account for potential violations of the key assumptions.

Methods: We discuss the key assumptions that should be satisfied in an MR setting. Read More

Schizophr Res 2019 Apr 9. Epub 2019 Apr 9.

Dept of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden.

Background: Life expectancy is reduced by 19 years in men and 17 in women with psychosis in Sweden, largely due to cardiovascular disease.

Aim: Assess whether a psychosocial health promotion intervention improves cardiometabolic risk factors, quality of life, and severity of illness in patients with psychotic disorders more than treatment as usual.

Methods: A pragmatic intervention trial testing a manual-based multi-component health promotion intervention targeting patients with psychosis. Read More

JMIR Ment Health 2019 Apr 12;6(4):e13202. Epub 2019 Apr 12.

Behavioral Research In Technology and Engineering Center, Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, United States.

Background: Depression is the most prevalent mental health problem. The need for effective treatments for depression far outstrips the availability of trained mental health professionals. Smartphones and other widely available technologies are increasingly being leveraged to deliver treatments for depression. Read More

Nervenarzt 2019 Apr 11. Epub 2019 Apr 11.

Klinik für Psychiatrie und Psychotherapie, Zentralinstitut für Seelische Gesundheit, Medizinische Fakultät Mannheim, Universität Heidelberg, J5, 68159, Mannheim, Deutschland.

The treatment of psychotic disorders and illnesses is a challenge for therapists and institutions due to the heterogeneity of the cause and course, refractory symptoms, lack of therapy adherence and high rates of relapse. These circumstances can be effectively counteracted by the flexibility of therapeutic approaches and settings. A useful but rarely used concept is the treatment of psychoses within the so-called track unit. Read More

Schizophr Res Cogn 2019 Sep 26;17:100135. Epub 2019 Mar 26.

Child Psychiatric Hospital, Mexico City, Mexico.

Studies evaluating the cognitive impairment in schizophrenic adolescents reported a variable course following antipsychotic treatment, with improvement being associated to patients' demographic or clinical characteristics.

Objectives: To examine the cognitive impairments of a Mexican sample of adolescents with schizophrenia using the MATRICS Consensus Cognitive Battery (MCCB) before and after six months of antipsychotic treatment and to determine which demographic or clinical characteristics could be associated to cognitive improvement.

Methods: A sample of 87 Mexican patients was evaluated with the MCCB. Read More

Lancet Psychiatry 2019 Apr 8. Epub 2019 Apr 8.

Somerset Partnership NHS Foundation Trust, South Petherton, UK.

Background: People with severe mental illnesses such as schizophrenia are three times more likely to smoke than the wider population, contributing to widening health inequalities. Smoking remains the largest modifiable risk factor for this health inequality, but people with severe mental illness have not historically engaged with smoking cessation services. We aimed to test the effectiveness of a combined behavioural and pharmacological smoking cessation intervention targeted specifically at people with severe mental illness. Read More

Neurosci Biobehav Rev 2019 Apr 8;101:78-84. Epub 2019 Apr 8.

Laboratory of Molecular Psychiatry, Hospital de Clínicas de Porto Alegre, Brazil; Department of Psychiatry, Federal University of Rio Grande do Sul, Brazil. Electronic address:

Bipolar disorder (BD) is commonly associated with comorbidities, especially substance use disorders. In light of this, the present review aimed to investigate the prevalence and clinical correlates of cannabis use in BD. Studies evaluating the prevalence of cannabis use among patients with BD and studies reporting a dichotomous sample of patients with cannabis use compared to those without the use were included. Read More

Scand J Public Health 2019 Apr 11:1403494819841960. Epub 2019 Apr 11.

2 Administrative Data Research Centre - Northern Ireland, Centre for Public Health, Queen's University Belfast, UK.

Aims: Higher incidence of psychotic disorders in high-income countries for migrants compared with the settled majority has been well established. However, it is less clear to what extent different migrants groups have accessed and utilised mental health care. This study aimed to identify the hazard of antipsychotic medication use in the largest migrant groups in Finland, compared with a Finnish-born comparison group, using high quality datasets maintained by Statistics Finland and Social Insurance Institution Finland, and linking socio-demographic and -economic characteristics to antipsychotic prescription purchases. Read More

Eur Child Adolesc Psychiatry 2019 Apr 9. Epub 2019 Apr 9.

Department of Psychiatry, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.

Psychosocial problems during adolescence are heterogenic, rather common, and unstable. At the same time, they are associated with an elevated risk of developing psychiatric disorders later in life. We aimed to describe the trajectories of psychosocial problems during adolescence and examine potential markers of persistence as compared to remission of these problems. Read More

Front Aging Neurosci 2019 27;11:67. Epub 2019 Mar 27.

Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

A functional brain network, termed the parietal memory network (PMN), has been shown to reflect the familiarity of stimuli in both memory encoding and retrieval. The function of this network has been separated from the commonly investigated default mode network (DMN) in both resting-state fMRI and task-activations. This study examined the deficit of the PMN in Alzheimer's disease (AD) patients using resting-state fMRI and independent component analysis (ICA) and investigated its diagnostic value in identifying AD patients. Read More

Am J Mens Health 2019 Mar-Apr;13(2):1557988319842985

6 Department of Medical Research, Tri-Service General hospital, National Defense Medical Center, Taipei, Republic of China.

This study aimed to investigate the association between males with psychosexual disorders (PSDs) and the risk of developing psychiatric disorders. A total of 34,972 enrolled patients, with 8,743 subjects who had suffered from PSD and 26,229 controls (1:3) matched for age and index year, from Taiwan's Longitudinal Health Insurance Database (LHID) from 2000 to 2015, selected from the National Health Insurance Research Database (NHIRD). After adjusting all the confounding factors, the multivariate Cox regression model was used to compare the risk of developing psychiatric disorders, between the PSD and non-PSD groups, during the 15 years of follow-up. Read More

Clin Lab 2019 Apr;65(4)

Background: Schizophrenia (SCZ) is a serious mental disorder that interferes with a person's cognitive processes and leads to social disability. A wide range of factors may play important roles in increased risk of SCZ development. Genetic contributors are among the most influential actors involved in different molecular mechanisms leading to the development of the nervous system, thus they play pivotal roles in psychotic disorders and SCZ de-velopment. Read More

Nervenarzt 2019 Apr 9. Epub 2019 Apr 9.

Sektion für experimentelle Neuropsychiatrie, Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum Freiburg, Medizinische Fakultät, Albert-Ludwigs-Universität Freiburg, Hauptstr. 5, 79104, Freiburg, Deutschland.

According to present concepts, primary psychotic disorders in the schizophrenia spectrum are probably caused by a complex interaction between multigenetic vulnerability and causally relevant environmental factors. In contrast, secondary psychotic disorders are the result of likely identifiable organic factors either in terms of a first causation (etiology) or a secondary cause (pathogenesis). In this context, autoantibody(ab)-associated autoimmune encephalitis (AE) plays an increasingly important role. Read More

Acta Psychiatr Scand 2019 Apr 9. Epub 2019 Apr 9.

Department of Psychiatry, McGill University, Montreal, Quebec, Canada.

Objective: To test whether duration of untreated psychosis (DUP) <3 months, recommended by the World Health Organization/International Early Psychosis Association, enhances the effects of an extended early intervention service (EEIS) on symptom remission.

Method: We examined data from a randomized controlled trial in which patients who received two-years of treatment in EIS for psychosis were subsequently randomized to either three-years of EEIS or three-years of regular care (RC). Using a DUP cut-off ≤12 weeks (approximately <3 months), patients were split into two groups. Read More

Neuropsychopharmacol Hung 2019 Mar;21(1):5-11

Nyírő Gyula Országos Pszichiátriai és Addiktológiai Intézet, Budapest, Hungary.

The clinical assessment of mentalization became one of the most important issues in clinical psychology and psychiatry. Despite extensive research efforts, the exact definition, classification, and evaluation of mentalization is unresolved, especially in psychotic disorders. The primary purpose of the present study was to investigate the factor structure of the Mentalization Questionnaire. Read More

Psychoneuroendocrinology 2019 Mar 22;106:85-94. Epub 2019 Mar 22.

Center for Contextual Psychiatry, Department of Neurosciences, KU Leuven, Leuven, Belgium.

Background: 22q11.2 deletion syndrome (22q11DS) is a genetic disorder associated with neurodevelopmental, anxiety and mood disorders, as well as an increased risk for developing psychosis. Cortisol levels and stress reactivity reflect hypothalamic-pituitary-adrenal (HPA)-axis activity, and are believed to be altered in individuals that often experience daily-life stress, depression, and psychotic symptoms. Read More

Arch Womens Ment Health 2019 Apr 6. Epub 2019 Apr 6.

Parkwood Institute, Mental Health Care Building, London, Ontario, Canada.

Psychiatry Res 2019 Apr 1;275:315-325. Epub 2019 Apr 1.

Ege University School of Medicine, Department of Child and Adolescent Psychiatry, Izmir, Turkey.

Prodromal symptoms of bipolar disorder (BD) and early onset schizophrenia spectrum disorder (EOSSD) overlap. To date, there has been no study directly comparing the prodromal stage of both disorders. Thus, the current study is aimed at determining which prodromal symptom clusters differentiate BD and EOSSD. Read More

Psychiatry Res 2019 Mar 30;275:310-314. Epub 2019 Mar 30.

Department of Psychiatry, University of Illinois-Chicago, Chicago, IL, USA.

Anxiety symptoms and anxiety disorders are common in both mood and psychotic disorders. However, limited comparative information exists regarding the long-term course of anxiety in schizoaffective disorder, bipolar disorder, and major depressive disorder. Prospective evaluation of the 20-year trajectory of self-reported anxiety and somatic-related anxiety in three major diagnostic groups, 43 schizoaffective patients, 47 bipolar patients, and 109 major depression patients was conducted. Read More

Schizophr Bull 2019 Apr 7. Epub 2019 Apr 7.

Department of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, CA.

Although meta-analyses suggest that schizophrenia (SZ) is associated with a more severe neurocognitive phenotype than mood disorders such as bipolar disorder, considerable between-subject heterogeneity exists in the phenotypic presentation of these deficits across mental illnesses. Indeed, it is unclear whether the processes that underlie cognitive dysfunction in these disorders are unique to each disease or represent a common neurobiological process that varies in severity. Here we used latent profile analysis (LPA) across 3 distinct cognitive domains (cognitive control, episodic memory, and visual integration; using data from the CNTRACS consortium) to identify distinct profiles of patients across psychotic illnesses. Read More

Eur Arch Psychiatry Clin Neurosci 2019 Apr 5. Epub 2019 Apr 5.

Department of Psychiatry, Taipei Veterans General Hospital, No. 201, Shih-Pai Road, Sec. 2, 11217, Taipei, Taiwan.

Studies have indicated thalamus-related network dysfunction in schizophrenia and psychotic disorders. However, whether thalamus-related functional connectivity (FC) contributes to the psychopathology and cognitive deficits of early-stage schizophrenia requires further investigation. A total of 34 patients with early-stage schizophrenia (illness duration = 1. Read More

Eur Child Adolesc Psychiatry 2019 Apr 4. Epub 2019 Apr 4.

The Child Psychiatry Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, 5262000, Tel Hashomer, Israel.

22q11.2 deletion syndrome (22q11.2DS) is the most common microdeletion in humans and is associated with high rates of attention deficit/hyperactivity disorder (ADHD), psychotic spectrum disorders and mood and anxiety disorders. Read More

Open Forum Infect Dis 2019 Apr 23;6(4):ofz100. Epub 2019 Mar 23.

Department of Medicine, University of Washington, Seattle.

Background: Direct-acting antiviral (DAA) therapy have been shown to be highly successful in clinical trials and observational studies, but less is known about treatment success in patients with a high burden of comorbid conditions, including mental health and substance use disorders. We evaluated DAA effectiveness across a broad spectrum of patients with human immunodeficiency virus (HIV)-hepatitis C virus (HCV) coinfection in routine clinical care, including those with psychosocial comorbid conditions.

Methods: The primary end point was sustained virologic response (SVR), defined as HCV RNA not detected or <25 IU/mL ≥10 weeks after treatment. Read More

Front Psychiatry 2019 20;10:131. Epub 2019 Mar 20.

Mental Health Centre Copenhagen, Gentofte Hospital, Copenhagen University Hospital, Hellerup, Denmark.

The notion of immunological pathways playing a role in the etiology of a subset of psychotic disorders has received increased interest in the last decades. One of the findings that has spiked interest herein, is an apparent link between autoimmune diseases and psychotic disorders. This is supported by genetic findings associating immune-related genetic markers with schizophrenia and clinical studies finding increased levels of inflammatory markers in patients with psychosis. Read More

Front Psychiatry 2019 21;10:120. Epub 2019 Mar 21.

Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zurich, Zurich, Switzerland.

This prospective study addresses risk factors of compulsory re-admission focusing on the role of the patient's subjective symptom distress and perceived social support, based on comprehensive patient and external (clinicians, study staff) assessments. Of the baseline sample, 168 (71%) patients with serious mental disorders, who had been compulsorily admitted to psychiatric inpatient care, were followed over 24 months after discharge within the framework of a RCT. During this time 36% had compulsory re-admissions; risk was highest immediately after discharge. Read More

BMJ Case Rep 2019 Apr 3;12(4). Epub 2019 Apr 3.

Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA.

This is a case of a 68-year-old man with Parkinson's disease who was admitted in the psychiatry floor for new-onset aggressive behaviour and hallucinations. On the third day of hospitalisation, he suddenly developed dyspnoea followed by an ECG showing atrial fibrillation with rapid ventricular response. A few seconds later, he went into cardiac arrest; he was resuscitated after multiple rounds of Advanced Cardiovascular Life Support. Read More

JAMA Psychiatry 2018 Nov;75(11):1156-1172

Department of Psychiatry, University Psychiatric Clinic, Psychiatric University Hospital, University of Basel, Basel, Switzerland.

Importance: Social and occupational impairments contribute to the burden of psychosis and depression. There is a need for risk stratification tools to inform personalized functional-disability preventive strategies for individuals in at-risk and early phases of these illnesses.

Objective: To determine whether predictors associated with social and role functioning can be identified in patients in clinical high-risk (CHR) states for psychosis or with recent-onset depression (ROD) using clinical, imaging-based, and combined machine learning; assess the geographic, transdiagnostic, and prognostic generalizability of machine learning and compare it with human prognostication; and explore sequential prognosis encompassing clinical and combined machine learning. Read More

CNS Neurosci Ther 2019 Apr 2. Epub 2019 Apr 2.

Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Hum Brain Mapp 2019 Apr 2. Epub 2019 Apr 2.

Department of Psychology, Northwestern University, Evanston, Illinois.

Self-reference is impaired in psychotic disorders such as schizophrenia, associated with disability, and closely related to characteristic patterns of aberrant brain connectivity. However, at present, it is unclear whether self-reference is impacted in pathogenesis of the disorder. Alterations in connectivity during a self-reference task or resting-state in the psychosis risk (i. Read More

Nervenarzt 2019 Apr 2. Epub 2019 Apr 2.

Psychiatrie, Psychotherapie und Psychosomatik, Vivantes Klinikum am Urban, Berlin, Deutschland.

Motivational interviewing (MI) has become established nowadays as an approach for a cooperative style of conversation to promote intrinsic motivation for change by exploring and resolving ambivalences. The change of addictive behavior is no longer sought by exerting pressure or lecturing/converting attempts of convincing or persuasion but by activating existing but "buried" or newly acquired self-motivation to change. The MI is now also used to change the treatment of other health-related behavior and chronic diseases, including schizophrenic disorders. Read More

Encephale 2018 Dec;44(6S):S8-S11

Service psychopathologie du développement, hôpital Femme-Mère-Enfant, hospices civils de Lyon, France; Institut des sciences cognitives Marc-Jeannerod, UMR 5304, CNRS et université Claude-Bernard-Lyon-1, France.

Very early onset schizophrenia begins before the age of 13. This form of schizophrenia is particularly difficult to diagnose. The differential diagnosis is difficult because some psychotic signs can be passing or be representative of an anxious or depressive disorder. Read More

Encephale 2018 Dec;44(6S):S55-S57

Section of Medical Anthropology (UVSQ, EA4498, Dante Laboratory), UFR of Health Sciences, 2, avenue de la Source-de-la-Bièvre, 78180 Montigny-Le-Bretonneux, France.

It is difficult to know precisely the history of a functional disease, unlike the natural history of infectious agents, tumour processes or poly-malformative syndromes. In the case of psychiatry, and especially schizophrenia and psychotic disorders, a retrospective look at artistic productions (writings and drawings) makes it possible to reconstitute a whole section of this pathological context. Through four medieval and modern examples, we will see how it is possible to do a paleo-psychiatry: Opicinus de Canistris (14 c. Read More

Encephale 2018 Dec;44(6S):S44-S46

CMP B, CHU, EA 7280, faculté de médecine, université d'Auvergne, BP 69 63003 Clermont-Ferrand Cedex 1, France; Fondation FondaMental, Créteil, France. Electronic address:

Migration can be considered as a major risk factor for the incidence of Psychotic disorders. It has observed in first and second-generation migrants. French studies provide concordant results. Read More

Encephale 2018 Dec;44(6S):S24-S29

Service de psychiatrie générale, département de psychiatrie, CHU Vaudois, Lausanne, Suisse, France. Electronic address:

The concept of staging is applied in medicine since many years, in order to better adapt treatment to patients' needs. Some authors have suggested one should also apply this concept to psychiatric disorders. If this approach seems to make sense, concrete progress in the domain are still limited. Read More

Can J Psychiatry 2019 Apr 1:706743719839314. Epub 2019 Apr 1.

6 Douglas Hospital Research Centre, Douglas Mental Health University Institute, Montreal, Quebec, Canada.

Objectives:: To report the outcomes of young people (aged 14-30 years) treated for major mental disorders in a lay health worker (LHW) intervention model in a rural district of conflict-ridden Kashmir, India.

Methods:: Over a 12-month follow-up, LHWs collected data on symptoms, functioning, quality of life and disability, and patients' and families' service engagement and satisfaction.

Results:: Forty trained LHWs (18 males and 22 females) identified 262 individuals who met the criteria for a diagnosis of a major mental disorder, connected them with specialists for treatment initiation (within 14 days), and provided follow-up and support to patients and families. Read More