163 results match your criteria Breathing-Related Sleep Disorder


Clinical and experimental aspects of breathing modulation by inflammation.

Auton Neurosci 2018 Nov 11. Epub 2018 Nov 11.

Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, QRO 76230, México. Electronic address:

Neuroinflammation is produced by local or systemic alterations and mediated mainly by glia, affecting the activity of various neural circuits including those involved in breathing rhythm generation and control. Several pathological conditions, such as sudden infant death syndrome, obstructive sleep apnea and asthma exert an inflammatory influence on breathing-related circuits. Consequently breathing (both resting and ventilatory responses to physiological challenges), is affected; e. Read More

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November 2018
1 Read

Prothrombotic state in children with obstructive sleep apnea.

Sleep Med 2018 Oct 13;53:101-105. Epub 2018 Oct 13.

Institut d'Investigació Sanitària de les Illes Balears (IdISBa), Palma de Mallorca, Spain; CIBER Enfermedades Respiratorias (CibeRes) (CB06/06), Spain; Department of Respiratory Medicine, Hospital Universitari Son Espases, Palma de Mallorca, Spain.

Objective: Increased blood coagulation might be one important mechanism linking obstructive sleep apnea (OSA) with cardiovascular diseases. We tested the association between several hemostatic parameters and sleep breathing-related variables in a representative pediatric population with a clinical suspicion of OSA.

Methods: Polysomnography was performed in 152 snoring children to diagnose OSA. Read More

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October 2018

On the generalizability of ECG-based obstructive sleep apnea monitoring: merits and limitations of the Apnea-ECG database.

Conf Proc IEEE Eng Med Biol Soc 2018 Jul;2018:6022-6025

Obstructive sleep apnea syndrome (OSAS) is a sleep disorder that affects a large part of the population and the development of algorithms using cardiovascular features for OSAS monitoring has been an extensively researched topic in the last two decades. Several studies regarding automatic apneic event classification using ECG derived features are based on the public Apnea-ECG database available on PhysioNet. Although this database is an excellent starting point for apnea topic investigations, in our study we show that algorithms for apneic-epochs classification that are successfully trained on this database (sensitivity < 85%, false detection rate <20%) perform poorly (sensitivity\textit<55%, false detection rate < 40%) in other databases which include patients with a broader spectrum of apneic events and sleep disorders. Read More

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July 2018
2 Reads

Assessment of myocardial CZT-SPECT recording in a forward-leaning "biker-like" position.

J Nucl Med 2018 Nov 2. Epub 2018 Nov 2.

CHRU-Nancy, Department of Nuclear Medicine and Nancyclotep molecular imaging platform, France.

This prospective randomized study aimed at assessing myocardial perfusion imaging recorded with the high-sensitivity "D.SPECT" cadmium-zinc-telluride (CZT) camera in a forward-leaning "biker-like" position, which may potentially lower diaphragmatic attenuation as well as reduce breathing-related cardiac motions, in manner comparable to the prone position proposed with other SPECT cameras. Patients referred to a stress-rest Tc-Sestamibi protocol and positioned in the "biker" position, with the chest leaning forward on the D. Read More

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November 2018
3 Reads

Stereotactic Body Radiotherapy: Does It Have a Role in Management of Hepatocellular Carcinoma?

Yonsei Med J 2018 Oct;59(8):912-922

Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.

Stereotactic body radiotherapy (SBRT) is a form of radiotherapy that delivers high doses of irradiation with high precision in a small number of fractions. However, it has not frequently been performed for the liver due to the risk of radiation-induced liver toxicity. Furthermore, liver SBRT is cumbersome because it requires accurate patient repositioning, target localization, control of breathing-related motion, and confers a toxicity risk to the small bowel. Read More

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October 2018

Maturation of Breathing-Related Inhibitory Neurotransmission in the Medulla Oblongata of the Embryonic and Perinatal Zebra Finch (Taeniopygia guttata).

Dev Neurobiol 2018 11 29;78(11):1081-1096. Epub 2018 Aug 29.

Department of Biological Sciences, Idaho State University, Pocatello, Idaho, 83209-8007.

The medullary portion of the embryonic zebra finch hindbrain was isolated and superfused with physiologically relevant artificial cerebral spinal fluid. This in vitro preparation produced uninterrupted rhythmic episodes of neural activity via cranial nerve IX (glossopharyngeal) from embryonic day 4 (E4) through hatching on E14. Cranial nerve IX carries motor activity to the glottis during the inspiratory phase of breathing, and we focused on the role of synaptic inhibition during the embryonic and perinatal maturation of this branchiomotor outflow. Read More

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November 2018

Social relationships and death-related behaviour in aquatic mammals: a systematic review.

Philos Trans R Soc Lond B Biol Sci 2018 Sep;373(1754)

Sea Watch Foundation, Paragon House, Wellington Place, New Quay, Ceredigion SA45 9NR, UK.

Some aquatic mammals appear to care for their dead, whereas others abandon their live offspring when conditions are unfavourable. This incredible variety in behaviours suggests the importance of comparing and contrasting mechanisms driving death-related behaviours among these species. We reviewed 106 cases of aquatic mammals (81 cetaceans and 25 non-cetaceans) reacting to a death event, and extrapolated 'participant' (, , and ) and 'social' characteristics (, , , and ) from published and unpublished literature. Read More

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September 2018
2 Reads

Antinociceptive efficacy and respiratory effects of dexmedetomidine in ball pythons (Python regius).

Am J Vet Res 2018 Jul;79(7):718-726

OBJECTIVE To determine antinociceptive efficacy, behavioral patterns, and respiratory effects associated with dexmedetomidine administration in ball pythons (Python regius). ANIMALS 12 ball pythons. PROCEDURES Antinociception was assessed by applying an infrared heat stimulus to the cranioventral surface of snakes during 2 experiments. Read More

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July 2018
2 Reads

An in silico performance characterization of respiratory motion guided 4DCT for high-quality low-dose lung cancer imaging.

Phys Med Biol 2018 Jul 27;63(15):155012. Epub 2018 Jul 27.

The University of Sydney School of Medicine, Sydney, NSW, Australia. ACRF Image X Institute, Central Clinical School, University of Sydney, Sydney, NSW, Australia.

This work aims to characterize the performance of an improved 4DCT technique aiming to overcome irregular breathing-related image artifacts. To address this, we have developed respiratory motion guided (RMG) 4DCT, which uses real-time breathing motion analysis to prospectively gate scans based on detection of irregular breathing. This is the first investigation of RMG-4DCT using a real-time software prototype, testing the hypothesis that it can reduce breathing irregularities during imaging, reduce image oversampling and improve image quality compared to a 'conventional' 4DCT protocol without breathing guidance. Read More

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July 2018
2 Reads

Snore Sound Analysis Can Detect the Presence of Obstructive Sleep Apnea Specific to NREM or REM Sleep.

J Clin Sleep Med 2018 Jun 15;14(6):991-1003. Epub 2018 Jun 15.

Sleep Disorders Centre, Department of Respiratory and Sleep Medicine, Princess Alexandra Hospital, Woolloongabba, Australia.

Study Objectives: Severities of obstructive sleep apnea (OSA) estimated both for the overall sleep duration and for the time spent in rapid eye movement (REM) and non-rapid eye movement (NREM) sleep are important in managing the disease. The objective of this study is to investigate a method by which snore sounds can be analyzed to detect the presence of OSA in NREM and REM sleep.

Methods: Using bedside microphones, snoring and breathing-related sounds were acquired from 91 patients with OSA (35 females and 56 males) undergoing routine diagnostic polysomnography studies. Read More

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June 2018
8 Reads

[Clinical observation of coblation assisted transoral microsurgery for the treatment of oral and oropharygneal malignancy].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Nov;31(22):1705-1710

Department of Otorhinolaryngology Head and Neck Surgery, Peking University First Hospital, Beijing, 100034, China.

To evaluate the feasibility and effectiveness of coblation assisted transoral surgery for the treatment of oral and oropharyngeal malignancy. 19 patients who suffered from oral or oropharyngeal malignant tumors underwent coblation assisted transoral surgery from August 2008 to August 2017 were studied. According to the tumor sites and pathological results, there were four oral squamous cell carcinoma (SCC) (two tongue carcinoma and two mouth floor carcinoma), eleven oropharygneal SCC (five tonsillar carcinoma, four soft palate carcinoma, one tongue base cartinama and one multiple carcinoma invading both soft palatine and hypopharynx), and four lymphatic and hematopoietic malignancies (three tonsillar tumors and one tumor invading both tonsil and tongue base). Read More

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November 2017
2 Reads

A Novel Sleep Respiratory Rate Detection Method for Obstructive Sleep Apnea Based on Characteristic Moment Waveform.

J Healthc Eng 2018 10;2018:1902176. Epub 2018 Jan 10.

School of Electrical Engineering and Electronic Information, Xihua University, Chengdu, China.

Obstructive sleep apnea (OSA) affecting human's health is a kind of major breathing-related sleep disorders and sometimes leads to nocturnal death. Respiratory rate (RR) of a sleep breathing sound signal is an important human vital sign for OSA monitoring during whole-night sleeping. A novel sleep respiratory rate detection with high computational speed based on characteristic moment waveform (CMW) method is proposed in this paper. Read More

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January 2018

Efferent projections of excitatory and inhibitory preBötzinger Complex neurons.

J Comp Neurol 2018 Jun 9;526(8):1389-1402. Epub 2018 Mar 9.

Department of Neurobiology, David Geffen School of Medicine, UCLA, Los Angeles, California, 90095-1763.

The preBötzinger Complex (preBötC), a compact medullary region essential for generating normal breathing rhythm and pattern, is the kernel of the breathing central pattern generator (CPG). Excitatory preBötC neurons in rats project to major breathing-related brainstem regions. Here, we provide a brainstem connectivity map in mice for both excitatory and inhibitory preBötC neurons. Read More

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June 2018
1 Read

Numerical study of dynamic glottis and tidal breathing on respiratory sounds in a human upper airway model.

Sleep Breath 2018 05 3;22(2):463-479. Epub 2017 Nov 3.

Department of Mechanical and Aerospace Engineering, University of Virginia, Charlottesville, VA, USA.

Background: Human snores are caused by vibrating anatomical structures in the upper airway. The glottis is a highly variable structure and a critical organ regulating inhaled flows. However, the effects of the glottis motion on airflow and breathing sound are not well understood, while static glottises have been implemented in most previous in silico studies. Read More

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May 2018
1 Read

Breathing above the brain stem: volitional control and attentional modulation in humans.

J Neurophysiol 2018 01 27;119(1):145-159. Epub 2017 Sep 27.

The Feinstein Institute for Medical Research, Manhasset, New York.

Whereas the neurophysiology of respiration has traditionally focused on automatic brain stem processes, higher brain mechanisms underlying the cognitive aspects of breathing are gaining increasing interest. Therapeutic techniques have used conscious control and awareness of breathing for millennia with little understanding of the mechanisms underlying their efficacy. Using direct intracranial recordings in humans, we correlated cortical and limbic neuronal activity as measured by the intracranial electroencephalogram (iEEG) with the breathing cycle. Read More

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January 2018
45 Reads

The Development of Technology for Effective Respiratory-Gated Irradiation Using an Image-Guided Small Animal Irradiator.

Radiat Res 2017 09 17;188(3):247-263. Epub 2017 Jul 17.

Cancer Research UK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Gray Laboratories, Oxford OX3 7DQ, United Kingdom.

The development of image-guided small animal irradiators represents a significant improvement over standard irradiators by enabling preclinical studies to mimic radiotherapy in humans. The ability to deliver tightly collimated targeted beams, in conjunction with gantry or animal couch rotation, has the potential to maximize tumor dose while sparing normal tissues. However, the current commercial platforms do not incorporate respiratory gating, which is required for accurate and precise targeting in organs subject to respiration related motions that may be up to the order of 5 mm in mice. Read More

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September 2017
26 Reads

Exercise-induced quadriceps muscle fatigue in men and women: effects of arterial oxygen content and respiratory muscle work.

J Physiol 2017 Aug 19;595(15):5227-5244. Epub 2017 Jun 19.

School of Kinesiology, University of British Columbia, Vancouver, BC, Canada.

Key Points: High work of breathing and exercise-induced arterial hypoxaemia (EIAH) can decrease O delivery and exacerbate exercise-induced quadriceps fatigue in healthy men. Women have a higher work of breathing during exercise, dedicate a greater fraction of whole-body V̇O2 towards their respiratory muscles and develop EIAH. Despite a greater reduction in men's work of breathing, the attenuation of quadriceps fatigue was similar between the sexes. Read More

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August 2017
12 Reads

Towards MRI temperature mapping in real time-the proton resonance frequency method with undersampled radial MRI and nonlinear inverse reconstruction.

Quant Imaging Med Surg 2017 Apr;7(2):251-258

Biomedizinische NMR Forschungs GmbH am Max-Planck-Institut für biophysikalische Chemie, Göttingen, Germany.

Background: Optimal control of minimally invasive interventions by hyperthermia requires dynamic temperature mapping at high temporal resolution.

Methods: Based on the temperature-dependent shift of the proton resonance frequency (PRF), this work developed a method for real-time MRI thermometry which relies on highly undersampled radial FLASH MRI sequences with iterative image reconstruction by regularized nonlinear inversion (NLINV). As a first step, the method was validated with use of a temperature phantom and organs (swine kidney) subjected to heating by warm water or a pulsed laser source. Read More

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April 2017
6 Reads

A Review on Detection and Treatment Methods of Sleep Apnea.

J Clin Diagn Res 2017 Mar 1;11(3):VE01-VE03. Epub 2017 Mar 1.

Professor, Department of Electronics and Communication Engineering, PSNA College of Engineering and Technology, Dindigul, Tamil Nadu, India.

This paper presents a review on detection and treatment methods of sleep apnea. Sleep apnea is the most common type of breathing-related sleep disorder. It manifests in a variety of behaviours from teeth grinding to night terrors as involuntary night-time events. Read More

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March 2017
10 Reads

A nationwide, cross-sectional survey on unusual sleep postures and sleep-disordered breathing-related symptoms in people with Down syndrome.

J Intellect Disabil Res 2017 07 5;61(7):656-667. Epub 2017 Apr 5.

Department of Health Sciences, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.

Background: People with Down syndrome (DS) often have sleep-disordered breathing (SDB). Unusual sleep postures, such as leaning forward and sitting, are observed in people with DS. This study aimed to clarify the prevalence of unusual sleep postures and their relationships with SDB-related symptoms (SDB-RSs), such as snoring, witnessed apnoea, nocturnal awakening and excessive daytime sleepiness. Read More

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July 2017
9 Reads

Effects of Antecedent Manipulations and Social Reinforcement to Increase Lateral Positioning in a Premature Infant with Obstructive Sleep Apnea.

Behav Anal Pract 2017 Mar 31;10(1):83-86. Epub 2016 Aug 31.

San Diego School of Medicine, University of California, San Diego, CA USA.

Recent research suggests supine positioning for sleeping infants is the safest position to prevent breathing related difficulties; however doing so can significantly increase obstruction in apneic infants resulting in decreased sleep quality. We implemented a multi-component treatment package compromised of antecedent interventions and parent-mediated social reinforcement to increase lateral positioning in a premature infant with obstructive sleep apnea. Results indicate that the intervention increased lateral positioning in the participant by over 80 % in the final phase of the study, indicating efficacy of the intervention. Read More

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Inhaler syncope.

Proc (Bayl Univ Med Cent) 2017 Jan;30(1):57-58

Division of Cardiology, Baylor Heart and Vascular Hospital, Dallas, Texas.

Syncope can result from certain activities that trigger an exaggerated physiological response in susceptible individuals; examples include cough, laugh, and micturition syncope. We report a novel cause for syncope, that due to reflex bradycardia and asystole produced by the use of asthma inhalers. We discuss the possible mechanisms for this effect and briefly review other breathing-related causes of bradycardia. Read More

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January 2017
2 Reads

Neurofibromatosis Clinic: A Report on Patient Demographics and Evaluation of the Clinic.

Can J Neurol Sci 2017 Sep 8;44(5):577-588. Epub 2016 Nov 8.

1Division of Neurosurgery,Toronto Western Hospital,University Health Network,Toronto,Ontario,Canada.

Background: Neurofibromatosis type 1 (NF1) is a common single-gene disorder. A multidisciplinary approach to the management of NF1 patients is necessitated by the heterogeneity of clinical manifestations. Although multidisciplinary paediatric clinics have been well established, there is a dearth of such resources for adults with NF1. Read More

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September 2017
6 Reads

MRI quantification of pancreas motion as a function of patient setup for particle therapy -a preliminary study.

J Appl Clin Med Phys 2016 09 8;17(5):60-75. Epub 2016 Sep 8.

Centro Nazionale di Adroterapia Oncologica.

Particle therapy (PT) has shown positive therapeutic results in local control of locally advanced pancreatic lesions. PT effectiveness is highly influenced by target localization accuracy both in space, since the pancreas is located in proximity to radiosensitive vital organs, and in time as it is subject to substantial breathing-related motion. The purpose of this preliminary study was to quantify pancreas range of motion under typical PT treatment conditions. Read More

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September 2016
8 Reads

Insomnia during pregnancy: Diagnosis and Rational Interventions.

Pak J Med Sci 2016 Jul-Aug;32(4):1030-7

Imran S. Khawaja MD, FAASM. Medical Director, Center for Sleep Medicine, VA Medical Center, Dallas, Texas, Associate Professor of Psychiatry and Neurology, UT Southwestern School of Medicine, USA.

Unlabelled: Sleep disturbances are common in pregnancy. Insomnia is a frequent sleep disturbance experienced by pregnant women which can be primary or due to co-morbid conditions. The differential diagnosis of insomnia in pregnancy includes anxiety disorders, mood disorders, breathing related sleep disorders and restless legs syndrome. Read More

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September 2016

Sleep Outcomes in Children With Single-Suture Craniosynostosis Compared With Unaffected Controls.

Cleft Palate Craniofac J 2017 11 12;54(6):734-738. Epub 2016 Aug 12.

Objective: To compare risk for sleep-disordered breathing between children with and without single-suture craniosynostosis.

Participants: A total of 184 children with single-suture craniosynostosis and 184 controls.

Main Outcome Measures: Parent reported sleep-disordered breathing-related symptoms. Read More

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November 2017
5 Reads

Influence of developmental nicotine exposure on glutamatergic neurotransmission in rhythmically active hypoglossal motoneurons.

Exp Neurol 2017 Jan 29;287(Pt 2):254-260. Epub 2016 Jul 29.

Department of Physiology, University of Arizona College of Medicine, Tucson, AZ 85724, USA; Department of Neuroscience, University of Arizona, Tucson, AZ 85724, USA. Electronic address:

Developmental nicotine exposure (DNE) is associated with increased risk of cardiorespiratory, intellectual, and behavioral abnormalities in neonates, and is a risk factor for apnea of prematurity, altered arousal responses and Sudden Infant Death Syndrome. Alterations in nicotinic acetylcholine receptor signaling (nAChRs) after DNE lead to changes in excitatory neurotransmission in neural networks that control breathing, including a heightened excitatory response to AMPA microinjection into the hypoglossal motor nucleus. Here, we report on experiments designed to probe possible postsynaptic and presynaptic mechanisms that may underlie this plasticity. Read More

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January 2017
15 Reads

Functional Interactions between Mammalian Respiratory Rhythmogenic and Premotor Circuitry.

J Neurosci 2016 07;36(27):7223-33

Departments of Applied Science and

Unlabelled: Breathing in mammals depends on rhythms that originate from the preBötzinger complex (preBötC) of the ventral medulla and a network of brainstem and spinal premotor neurons. The rhythm-generating core of the preBötC, as well as some premotor circuits, consist of interneurons derived from Dbx1-expressing precursors (Dbx1 neurons), but the structure and function of these networks remain incompletely understood. We previously developed a cell-specific detection and laser ablation system to interrogate respiratory network structure and function in a slice model of breathing that retains the preBötC, the respiratory-related hypoglossal (XII) motor nucleus and XII premotor circuits. Read More

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July 2016
7 Reads

Imaging the Respiratory Effects of Opioids in the Human Brain.

Adv Exp Med Biol 2016 ;903:145-56

CUBRIC, School of Psychology, Cardiff University, Cardiff, UK.

Opioid analgesia is limited by the potentially fatal side effect of respiratory depression. In humans the brain mechanisms of opioid-induced respiratory depression are poorly understood. Investigating pharmacological influences upon breathing helps us to understand better the brain's respiratory control networks. Read More

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Olfactory Bulb Field Potentials and Respiration in Sleep-Wake States of Mice.

Neural Plast 2016 10;2016:4570831. Epub 2016 May 10.

Institute for Physiology and Pathophysiology, Heidelberg University, 69120 Heidelberg, Germany.

It is well established that local field potentials (LFP) in the rodent olfactory bulb (OB) follow respiration. This respiration-related rhythm (RR) in OB depends on nasal air flow, indicating that it is conveyed by sensory inputs from the nasal epithelium. Recently RR was found outside the olfactory system, suggesting that it plays a role in organizing distributed network activity. Read More

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December 2016
10 Reads

Advances and New Approaches to Managing Sleep-Disordered Breathing Related to Chronic Pulmonary Disease.

Sleep Med Clin 2016 Jun 8;11(2):257-64. Epub 2016 Mar 8.

Pulmonary, Critical Care and Sleep Medicine, Mayo Clinic, 200 1st Street Southwest, Rochester, MN 55905, USA. Electronic address:

Chronic obstructive pulmonary disease (COPD) is a common disease affecting about 20 million US adults. Sleep-disordered breathing (SDB) problems are frequent and poorly characterized for patients with COPD. Both the well-known success of noninvasive ventilation (NIV) in the acute COPD exacerbation in the hospital setting and that NIV is the cornerstone of chronic therapy for SDBs have urged the attention of the medical community to determine the impact of NIV on chronic COPD management with and without coexisting SDBs. Read More

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June 2016
9 Reads

Text Mining of Journal Articles for Sleep Disorder Terminologies.

PLoS One 2016 20;11(5):e0156031. Epub 2016 May 20.

School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan.

Objective: Research on publication trends in journal articles on sleep disorders (SDs) and the associated methodologies by using text mining has been limited. The present study involved text mining for terms to determine the publication trends in sleep-related journal articles published during 2000-2013 and to identify associations between SD and methodology terms as well as conducting statistical analyses of the text mining findings.

Methods: SD and methodology terms were extracted from 3,720 sleep-related journal articles in the PubMed database by using MetaMap. Read More

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July 2017
9 Reads

Prenatal assessment of pulmonary maturity on 3-D ultrasound.

J Obstet Gynaecol Res 2016 Sep 11;42(9):1086-93. Epub 2016 May 11.

Department of Obstetrics and Gynecology, First Affiliated Hospital, Medical College, Xi'an JiaoTong University, Xi'an, Shanxi Province, China.

Aim: The aim of this study was to assess the feasibility and accuracy of 3-D ultrasound indices to evaluate fetal lung maturity, and to establish a normal reference for fetal lung volume (FLV) and fetal lung-to-liver intensity ratio (FLLIR) in a Chinese population.

Methods: A total of 1022 pregnant women with singleton pregnancy were prospectively studied between June 2008 to June 2011. Ultrasound examination was performed. Read More

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September 2016
4 Reads

Asthma-specific health-related quality of life of people in Great Britain: A national survey.

J Asthma 2016 11 26;53(9):975-82. Epub 2016 Apr 26.

a Asthma UK , London , United Kingdom.

Background: Although the ultimate goal of asthma treatment is to improve asthma-specific Health-Related Quality-Of-Life (HRQOL), in the UK population this is insufficiently studied. National asthma-specific HRQOL data is needed to inform strategies to address this condition.

Aims And Objectives: To benchmark asthma-specific HRQOL in a national survey of adults with asthma, and explore differences in this measure within subsections of the population. Read More

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November 2016
14 Reads

Inhibition Patterns the Whisking Rhythm.

Neuron 2016 04;90(2):211-3

Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, CH-1015, Switzerland. Electronic address:

In this issue of Neuron, Deschênes et al. (2016) propose that rhythmic inhibition of whisker motor neurons is a key pattern generator underlying exploratory whisking. The inhibitory premotor neurons located in the brainstem reticular formation are synchronized by breathing-related oscillators. Read More

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April 2016
5 Reads

Respiratory Variability during Sleep in Methadone Maintenance Treatment Patients.

J Clin Sleep Med 2016 Apr 15;12(4):607-16. Epub 2016 Apr 15.

Woolcock Institute of Medical Research and Sydney Medical School, University of Sydney, Glebe, New South Wales, Australia.

Study Objectives: Methadone maintenance treatment (MMT) patients have a high prevalence of central sleep apnea and ataxic breathing related to damage to central respiratory rhythm control. However, the quantification of sleep apnea indices requires laborious manual scoring, and ataxic breathing pattern is subjectively judged by visual pattern recognition. This study proposes a semi-automated technique to characterize respiratory variability in MMT patients. Read More

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April 2016
7 Reads

Deep Inspiration Breath Hold-Based Radiation Therapy: A Clinical Review.

Int J Radiat Oncol Biol Phys 2016 Mar 17;94(3):478-92. Epub 2015 Dec 17.

Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.

Several recent developments in linear accelerator-based radiation therapy (RT) such as fast multileaf collimators, accelerated intensity modulation paradigms like volumeric modulated arc therapy and flattening filter-free (FFF) high-dose-rate therapy have dramatically shortened the duration of treatment fractions. Deliverable photon dose distributions have approached physical complexity limits as a consequence of precise dose calculation algorithms and online 3-dimensional image guided patient positioning (image guided RT). Simultaneously, beam quality and treatment speed have continuously been improved in particle beam therapy, especially for scanned particle beams. Read More

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March 2016
8 Reads

Sleep medicine in Taiwan.

Sleep Biol Rhythms 2016;14:11-19. Epub 2015 Nov 18.

Sleep Center, Pulmonary and Critical Care Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan ; Medical College, Fu Jen Catholic University, Taipei, Taiwan.

The sleep medicine is a young medical science in Taiwan. It began from less than 10 sleep beds 20 years ago in four hospitals all over Taiwan. By the organization of sleep team in Chang Gung Memorial Hospital and the initiation of Taiwan Society of Sleep Medicine, sleep medicine becomes a popular medicine in the past decades. Read More

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November 2015
2 Reads

Insight into Best Variables for COPD Case Identification: A Random Forests Analysis.

Chronic Obstr Pulm Dis 2016;3(1):406-418

Weill Cornell Medical Center, New York, New York.

Rationale: This study is part of a larger, multi-method project to develop a questionnaire for identifying undiagnosed cases of chronic obstructive pulmonary disease (COPD) in primary care settings, with specific interest in the detection of patients with moderate to severe airway obstruction or risk of exacerbation.

Objectives: To examine 3 existing datasets for insight into key features of COPD that could be useful in the identification of undiagnosed COPD.

Methods: Random forests analyses were applied to the following databases: COPD Foundation Peak Flow Study Cohort (N=5761), Burden of Obstructive Lung Disease (BOLD) Kentucky site (N=508), and COPDGene® (N=10,214). Read More

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January 2016
12 Reads

Breathing-related changes of respiratory resistance in vocal cord dysfunction.

Respirology 2016 08 22;21(6):1134-6. Epub 2016 Jan 22.

Department of Pediatric Lung Function Testing, Children Hospital, Vandoeuvre, France.

Vocal cord dysfunction induced by exercise in children with uncontrolled asthma was identified by laryngoscopy. The paradoxical adduction of the vocal cords was also indicated by the breathing-related changes of the forced oscillation respiratory resistance showing prominent increase during inspiration and a large positive difference between inspiration and expiration. The breathing-related changes of respiratory resistance offer thus a useful first-line technique to diagnose vocal cord dysfunction. Read More

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August 2016
8 Reads

Breathing rate estimation during sleep using audio signal analysis.

Conf Proc IEEE Eng Med Biol Soc 2015 ;2015:5981-4

Sleep is associated with important changes in respiratory rate and ventilation. Currently, breathing rate (BR) is measured during sleep using an array of contact and wearable sensors, including airflow sensors and respiratory belts; there is need for a simplified and more comfortable approach to monitor respiration. Here, we present a new method for BR evaluation during sleep using a non-contact microphone. Read More

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August 2016
2 Reads

Reliability and Determinants of Self-Evaluation of Breathing Questionnaire (SEBQ) Score: A Symptoms-Based Measure of Dysfunctional Breathing.

Appl Psychophysiol Biofeedback 2016 Mar;41(1):111-20

Department of Community and Health Services: Osteopathy, Unitec Institute of Technology, Private Bag 92025, Auckland, 1142, New Zealand.

Dysfunctional breathing is characterised by an abnormal breathing pattern leading to respiratory symptoms. The 25-item Self Evaluation of Breathing Questionnaire (SEBQ) has been developed to measure breathing-related symptoms and their severity but lacks thorough evaluation. To determine reproducibility, internal consistency and predictors of SEBQ score, 180 participants completed an online SEBQ with additional demographic and lifestyle questions. Read More

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March 2016
14 Reads

Impact of motion induced artifacts on automatic registration of lung tumors in Tomotherapy.

Phys Med 2015 Dec 16;31(8):963-968. Epub 2015 Sep 16.

MIRO Lab., Université catholique de Louvain, Saint-Luc University Hospital, Brussels, Belgium. Electronic address:

Purpose: Tomotherapy MV-CT acquisitions of lung tumors lead to artifacts due to breathing-related motion. This could preclude the reliability of tumor based positioning. We investigate the effect of these artifacts on automatic registration and determine conditions under which correct positioning can be achieved. Read More

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December 2015
2 Reads

Studying respiratory rhythm generation in a developing bird: Hatching a new experimental model using the classic in vitro brainstem-spinal cord preparation.

Respir Physiol Neurobiol 2016 Apr 24;224:62-70. Epub 2015 Aug 24.

Department of Biological Sciences, Idaho State University, Pocatello, ID, 83 209, USA; Department of Dental Sciences, Idaho State University, Pocatello, ID, 83 209 USA. Electronic address:

It has been more than thirty years since the in vitro brainstem-spinal cord preparation was first presented as a method to study automatic breathing behaviors in the neonatal rat. This straightforward preparation has led to an incredible burst of information about the location and coordination of several spontaneously active microcircuits that form the ventrolateral respiratory network of the brainstem. Despite these advances, our knowledge of the mechanisms that regulate central breathing behaviors is still incomplete. Read More

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April 2016
3 Reads

Learned vocal and breathing behavior in an enculturated gorilla.

Anim Cogn 2015 Sep 3;18(5):1165-79. Epub 2015 Jul 3.

Department of Psychology, University of Wisconsin-Madison, 1202 W. Johnson St., Madison, WI, 53707, USA,

We describe the repertoire of learned vocal and breathing-related behaviors (VBBs) performed by the enculturated gorilla Koko. We examined a large video corpus of Koko and observed 439 VBBs spread across 161 bouts. Our analysis shows that Koko exercises voluntary control over the performance of nine distinctive VBBs, which involve variable coordination of her breathing, larynx, and supralaryngeal articulators like the tongue and lips. Read More

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September 2015

Prevalence of Sleep-Disordered Breathing-Related Symptoms in Patients with Chronic Heart Failure and Reduced Ejection Fraction.

Can J Cardiol 2015 Jul 25;31(7):839-45. Epub 2015 Feb 25.

Department of Internal Medicine II, University Hospital Regensburg, Regensburg, Germany. Electronic address:

Background: Sleep-disordered breathing (SDB) is highly prevalent in patients with chronic heart failure (CHF) and is associated with a poor prognosis. Data on SDB-related symptoms and vigilance impairment in patients with CHF and SDB are rare. Thus, the objective of the present study was to assess a wide spectrum of SDB-related symptoms and objective vigilance testing in patients with CHF with and without SDB. Read More

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July 2015
13 Reads

Poor sleep quality and silent markers of cerebral small vessel disease: a population-based study in community-dwelling older adults (The Atahualpa Project).

Sleep Med 2015 Mar 28;16(3):428-31. Epub 2015 Jan 28.

Mayo Clinic College of Medicine, Jacksonville, FL, United States.

Background/objectives: Evidence of a relationship between non-breathing-related sleep symptoms and silent markers of cerebral small vessel disease (SVD) is scarce. The present study aimed to evaluate this association in older people living in rural Ecuador, where the burden of stroke is on the rise.

Methods: A group of Atahualpa residents, aged ≥60 years, were interviewed with a validated Spanish version of the Pittsburgh Sleep Quality Index, and underwent magnetic resonance imaging (MRI) for identification of silent markers of SVD. Read More

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March 2015
11 Reads

Auto-adjusting and advanced positive airway pressure therapeutic modalities.

Semin Respir Crit Care Med 2014 Oct 29;35(5):593-603. Epub 2014 Oct 29.

Division of Pulmonary and Critical Care Medicine, Clinical Immunology and Allergy, David Geffen School of Medicine, Los Angeles, California.

Continuous positive airway pressure (CPAP) therapy is the first-line treatment for obstructive sleep apnea (OSA). Although the gold standard for the treatment of OSA, CPAP may not be the optimal modality to treat more complex sleep disordered breathing such as Cheyne-Stokes respirations, opioid-induced central apnea, and complex sleep disordered breathing related to chronic hypoventilation syndromes (obesity-hypoventilation syndrome, restrictive thoracic disease due to neuromuscular or thoracic cage disease, chronic obstructive pulmonary disease). Newer generation auto-adjusting PAP devices are increasingly being used to treat OSA. Read More

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October 2014
11 Reads

Laser ablation of Dbx1 neurons in the pre-Bötzinger complex stops inspiratory rhythm and impairs output in neonatal mice.

Elife 2014 Jul 15;3:e03427. Epub 2014 Jul 15.

Department of Applied Science, The College of William and Mary, Williamsburg, United States

To understand the neural origins of rhythmic behavior one must characterize the central pattern generator circuit and quantify the population size needed to sustain functionality. Breathing-related interneurons of the brainstem pre-Bötzinger complex (preBötC) that putatively comprise the core respiratory rhythm generator in mammals are derived from Dbx1-expressing precursors. Here, we show that selective photonic destruction of Dbx1 preBötC neurons in neonatal mouse slices impairs respiratory rhythm but surprisingly also the magnitude of motor output; respiratory hypoglossal nerve discharge decreased and its frequency steadily diminished until rhythm stopped irreversibly after 85±20 (mean ± SEM) cellular ablations, which corresponds to ∼15% of the estimated population. Read More

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July 2014
3 Reads

Novel method for conscious airway resistance and ventilation estimation in neonatal rodents using plethysmography and a mechanical lung.

Respir Physiol Neurobiol 2014 Sep 10;201:75-83. Epub 2014 Jul 10.

Department of Physiology and Pharmacology, Hotchkiss Brain Institute & Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. Electronic address:

In unrestrained whole body plethysmography, tidal volume is commonly determined using the barometric method, which assumes that temperature and humidity changes (the 'barometric component') are solely responsible for breathing-related chamber pressure fluctuations. However, in small animals chamber pressure is also influenced by a 'mechanical component' dependent on airway resistance and airflow. We devised a novel 'mechanical lung' capable of simulating neonatal mouse breathing in the absence of temperature or humidity changes. Read More

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September 2014