3,686 results match your criteria Breathe Sheffield England[Journal]


I Can't Breathe!

Authors:
Margaret Tempero

J Natl Compr Canc Netw 2020 Jul;18(7):793

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http://dx.doi.org/10.6004/jnccn.2020.0033DOI Listing

Environmental Pollution and Lung Cancer: The Carcinogenic Power of the Air We Breathe.

Arch Bronconeumol 2020 Jun 29. Epub 2020 Jun 29.

Servicio de Neumología, Hospital Universitario Vall d'Hebron, Barcelona, España; CIBER Enfermedades Respiratorias (CIBERES), Madrid, España; Departamento de Medicina, Universidad Autónoma de Barcelona, Barcelona, España.

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http://dx.doi.org/10.1016/j.arbres.2020.05.031DOI Listing

Delivery of Positive End-Expiratory Pressure Using Self-Inflating Bags during Newborn Resuscitation Is Possible Despite Mask Leak.

Neonatology 2020 Jul 1:1-8. Epub 2020 Jul 1.

Department of Anesthesiology and Intensive Care, Stavanger University Hospital, Stavanger, Norway.

Background: Ventilation is the key intervention to resuscitate non-breathing newborns. Positive end-expiratory pressure (PEEP) may facilitate lung-liquid clearance and help establish functional residual capacity.

Objectives: The aim of this study was to describe how mask leak and ventilation rates affect delivered PEEP and tidal volumes during newborn resuscitations using a self-inflating bag with an integrated PEEP valve. Read More

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http://dx.doi.org/10.1159/000507829DOI Listing

Human lungs are created to breathe clean air: the questionable quantification of vaping safety "95% less harmful".

N Z Med J 2020 Jun 26;133(1517):100-106. Epub 2020 Jun 26.

Respiratory Physician, Counties Manukau District Health Board, Auckland.

The New Zealand government is aiming for Smokefree Aotorea, equivalent to a reduction in smoking prevalence to 5% or less by 2025. E-cigarettes may be one tool to meet this target, but how safe are they? Little is known about their long-term health implications in humans. In 2015, Public Health England commissioned a report summarising the available literature on e-cigarettes and coined the now well-known quantification that "e-cigarettes are 95% less harmful to your health than normal cigarettes". Read More

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Increased Work of Breathing Due to Tracheomalacia in Neonates.

Ann Am Thorac Soc 2020 Jun 24. Epub 2020 Jun 24.

Cincinnati Children's Hospital Medical Center, 2518, Center for Pulmonary Imaging Research, Cincinnati, Ohio, United States.

Rationale: Dynamic collapse of the tracheal lumen (tracheomalacia) occurs frequently in premature neonates, particularly those with common comorbidities such as bronchopulmonary dysplasia. The tracheal collapse increases the effort necessary to breathe (work of breathing, WOB). However, quantifying the increased WOB related to tracheomalacia has previously not been possible. Read More

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http://dx.doi.org/10.1513/AnnalsATS.202002-162OCDOI Listing

Coalescing IoT and Wi-Fi technologies for an optimized approach in urban route planning.

Environ Sci Pollut Res Int 2020 Jun 17. Epub 2020 Jun 17.

Banasthali Vidyapith, Vanasthali, Rajasthan, India.

The quality of air that we breathe is one of the more serious environmental challenges that the government faces all around the world. It is a matter of concern for almost all developed and developing countries. The National Air Quality Index (NAQI) in India was first initiated and unveiled by the central government under the Swachh Bharat Abhiyan (Clean India Campaign). Read More

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http://dx.doi.org/10.1007/s11356-020-09477-7DOI Listing

Struggling to Breathe: Inspiratory Muscle Training in Adolescent Athletes.

J Voice 2020 Jun 14. Epub 2020 Jun 14.

Southeast Missouri State University, Cape Girardeau, Missouri.

Objective: Dyspnea is a primary characteristic of exercise-induced laryngeal obstruction and prevents individuals from inhaling and exhaling without effort. This single subject research study investigated the effects of inspiratory muscle training (IMT) on exercise-induced symptoms characteristic of exercise-induced laryngeal obstruction in adolescent athletes.

Methods: Five weeks of IMT was provided to five adolescent athletes, four females and one male, aged 10 to 16. Read More

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http://dx.doi.org/10.1016/j.jvoice.2020.05.002DOI Listing

Helping Africa to breathe when COVID-19 strikes.

Authors:
P M Fenton

Int J Tuberc Lung Dis 2020 06;24(6):636-637

Independent Consultant, Meyra, 47800, Agnac, France, , Email:

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http://dx.doi.org/10.5588/ijtld.20.0208DOI Listing

Everyone must be able to breathe: a plan to support diversity and inclusion in respiratory physiology.

Am J Physiol Lung Cell Mol Physiol 2020 Jul 17;319(1):L159-L162. Epub 2020 Jun 17.

Department of Ecology, Evolution, and Organismal Biology, Kennesaw State University, Kennesaw, Georgia.

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http://dx.doi.org/10.1152/ajplung.00269.2020DOI Listing

Participation in a workplace smoking cessation program incentivized by lowering the cost of health care coverage: Findings from the LLUH BREATHE cohort.

Tob Prev Cessat 2020 7;6:23. Epub 2020 Apr 7.

School of Public Health, Loma Linda University, Loma Linda, United States.

Introduction: Systematic analyses of workplace smoking cessation programs indicate that efficacy can be enhanced by using incentives. There is variation in the type of incentives used and their effect on participation and efficacy. The aim of our study was to examine whether lowering employee health plan costs (employee contributions, co-pays) encourage employee smokers to participate in workplace smoking cessation. Read More

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http://dx.doi.org/10.18332/tpc/118237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291893PMC

Exploring Factors Influencing Practice of Neonatal Resuscitation with Bag and Mask in Ethiopia: Analysis from 2016 National Emergency Obstetric and Newborn Care Survey.

J Multidiscip Healthc 2020 22;13:471-476. Epub 2020 May 22.

Mekelle University, College of Health Sciences, Department of Midwifery, Mekelle, Tigray, Ethiopia.

Background: Globally, more than 7 million children die under the age of five and the highest proportion of death is during the first 28 days of life. For babies who do not breathe at birth, neonatal resuscitation is critical in reducing intra-partum related neonatal deaths by 30%. Yet, there is a dearth of studies on the provision of neonatal resuscitation in Ethiopia. Read More

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http://dx.doi.org/10.2147/JMDH.S246347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250297PMC

Adding video-debriefing to Helping-Babies-Breathe training enhanced retention of neonatal resuscitation knowledge and skills among health workers in Uganda: a cluster randomized trial.

Glob Health Action 2020 Dec;13(1):1743496

Center for International Health, University of Bergen , Bergen, Norway.

Background: Skilled birth attendants must be competent to provide prompt resuscitation to save newborn lives at birth. Both knowledge and skills (competence) decline with time after training but the optimal duration for refresher training among frontline-skilled birth attendants in low-resource settings is unknown.

Objectives: We assessed the effect of an innovative Helping-Babies-Breathe simulation-based teaching method using video-debriefing compared to standard Helping-Babies-Breathe training on 1) neonatal resuscitation knowledge and skills attainment and 2) competence retention among skilled birth attendants in Northern Uganda. Read More

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http://dx.doi.org/10.1080/16549716.2020.1743496DOI Listing
December 2020

Sleep-disordered breathing after lung transplantation: an observational cohort study.

Am J Transplant 2020 Jun 9. Epub 2020 Jun 9.

Clinical department of Respiratory Diseases, UZ Leuven - BREATHE, department CHROMETA, KU Leuven, Campus Gasthuisberg, Herestraat 49, B-3000, Leuven, Belgium.

Data concerning sleep-disordered breathing (SDB) after lung transplantation (LTX) are scarce. This study aims to analyze prevalence, associated factors and impact on survival of moderate to severe SDB in a large cohort of consecutive LTX patients (n=219). Patients underwent a diagnostic polysomnography 1 year after LTX. Read More

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http://dx.doi.org/10.1111/ajt.16130DOI Listing

Helping Babies Breathe (2nd edition) implementation on a shoestring budget in Zanzibar, Tanzania.

Matern Health Neonatol Perinatol 2020 1;6. Epub 2020 Jun 1.

Duke University, Durham, NC USA.

Background: To assess the efficacy and viability of implementing Helping Babies Breathe, a neonatal resuscitation program for resource-limited environments on a small budget in two of the largest delivery centers in Zanzibar, Tanzania. The quality improvement initiative concentrated on training midwives, who directly care for neonates at birth on Helping Babies Breathe to address high rates of neonatal mortality secondary to birth asphyxia.

Methods: The convenience sample was 59 midwives working in the two delivery centers of interest in Zanzibar, Tanzania. Read More

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http://dx.doi.org/10.1186/s40748-020-00117-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268599PMC

Metabolite cycled liver H MRS on a 7 T parallel transmit system.

NMR Biomed 2020 Jun 8:e4343. Epub 2020 Jun 8.

Department of Radiology, Imaging Division, University Medical Center Utrecht, Utrecht, The Netherlands.

Introduction: Single-voxel H MRS in body applications often suffers from respiratory and other motion induced phase and frequency shifts, which lead to incoherent averaging and hence to suboptimal results.

Methods: Here we show the application of metabolite cycling (MC) for liver STEAM-localized H MRS on a 7 T parallel transmit system, using eight transmit-receive fractionated dipole antennas with 16 additional, integrated receive loops. MC-STEAM measurements were made in six healthy, lean subjects and compared with STEAM measurements using VAPOR water suppression. Read More

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http://dx.doi.org/10.1002/nbm.4343DOI Listing

Development and testing of a new-generation aerosol exposure system: The independent holistic air-liquid exposure system (InHALES).

Toxicol In Vitro 2020 Jun 5;67:104909. Epub 2020 Jun 5.

Philip Morris Products & Manufacturing SA, Quai Jeanrenaud 5, 2000 Neuchâtel, Switzerland.

The dose of inhaled materials delivered to the respiratory tract is to a large extent a function of the kinetics of particle deposition and gas dissolution on or in the airway and lung epithelia, and therefore of the structural and functional properties of the respiratory tract. In vitro aerosol exposure systems commonly do not simulate these properties, which may result in the delivery of non-realistic, non-human-relevant doses of inhalable test substances to the in vitro biological test systems. We developed a new-generation in vitro aerosol exposure system, the InHALES, that can, like the human respiratory tract, actively breathe, operate medical inhalers, or take puffs from tobacco products. Read More

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http://dx.doi.org/10.1016/j.tiv.2020.104909DOI Listing

Assessment of inhaled dust by workers and suspended dust for pollution control change and ergonomic intervention in metal casting industry: A cross-sectional study.

Heliyon 2020 May 30;6(5):e04067. Epub 2020 May 30.

Faculty of Medicine, University of Udayana, Bali, Indonesia.

Metal casting industry including is an industry which produce high dust pollution (fly ash). Improvements in the form of ergonomic interventions have been carried out by many companies, but do not guarantee all parameters run well. The total indoor suspended dust (TSP) measurement results are not enough to guarantee healthy working conditions. Read More

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http://dx.doi.org/10.1016/j.heliyon.2020.e04067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264714PMC

Towards the Essence of Progressiveness: Bringing Progressive Fibrosing Interstitial Lung Disease (PF-ILD) to the Next Stage.

J Clin Med 2020 Jun 3;9(6). Epub 2020 Jun 3.

Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Department CHROMETA, KU Leuven, B-3000 Leuven, Belgium.

Although only recently introduced in the ILD community, the concept of progressive fibrosing interstitial lung disease (PF-ILD) has rapidly acquired an important place in the management of non-idiopathic pulmonary fibrosis fibrosing ILD (nonIPF fILD) patients. It confirms a clinical gut feeling that an important subgroup of nonIPF fILD portends a dismal prognosis despite therapeutically addressing the alleged triggering event. Due to several recently published landmark papers showing a treatment benefit with currently available antifibrotic drugs in PF-ILD patients, endorsing a PF-ILD phenotype has vital therapeutic consequences. Read More

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http://dx.doi.org/10.3390/jcm9061722DOI Listing

Terrestrial Salamanders Maintain Habitat Suitability under Climate Change despite Trade-Offs between Water Loss and Gas Exchange.

Physiol Biochem Zool 2020 Jul/Aug;93(4):310-319

Physiological acclimation has the potential to improve survival during climate change by reducing sensitivity to warming. However, acclimation can produce trade-offs due to links between related physiological traits. Water loss and gas exchange are intrinsically linked by the need for respiratory surfaces to remain moist. Read More

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http://dx.doi.org/10.1086/709558DOI Listing

Sustainability in Inhaled Drug Delivery.

Pharmaceut Med 2020 Jun;34(3):191-199

Pharmacentric Solutions Ltd, London, UK.

Asthma and chronic obstructive pulmonary disease (COPD) are amongst the most common chronic diseases worldwide, and are largely preventable by improving the quality of the air we breathe. The most commonly deployed treatment, the metered dose inhaler (MDI), uses hydrofluorocarbon propellants, which are powerful greenhouse gases that contribute disproportionately to the climate crisis. Alternative treatment strategies are required if we are to avoid contributing to the worst effects of climate change. Read More

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http://dx.doi.org/10.1007/s40290-020-00339-8DOI Listing

Assessment of the Wearability of Facemasks against Air Pollution in Primary School-Aged Children in London.

Int J Environ Res Public Health 2020 Jun 2;17(11). Epub 2020 Jun 2.

Institute of Occupational Medicine (IOM), Research Avenue North, Riccarton, Edinburgh, EH14 4AP, UK.

Air pollution is a major health problem and children are particularly vulnerable to the adverse effects. Facemasks are one form of protection but, to be effective, they need to filter out airborne pollutants, fit the face well and be wearable. In this pilot study, we assess the perceived wearability of three facemasks (Vogmask, TuHao and ReSpimask) marketed in the UK as being designed to protect children against exposure to air pollution. Read More

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http://dx.doi.org/10.3390/ijerph17113935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312046PMC

E-cigarettes, heat-not-burn and smokeless tobacco products.

Authors:

Breathe (Sheff) 2020 Mar;16(1):161ELF

An e-cigarette is a battery-operated device that allows the user to breathe in nicotine through a vapour. They are sometimes referred to as Electronic Nicotine Delivery Systems (ENDS) and this term also includes devices such as vapes, e-hookahs, e-pipes and e-cigars. These devices work by heating a liquid so that it turns into a vapour for the user to inhale, or 'vape'. Read More

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http://dx.doi.org/10.1183/20734735.ELF161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249783PMC

Clues beyond the lung: an unusual diagnosis in an infant with chronic lung disease.

Breathe (Sheff) 2020 Mar;16(1):190319

Paediatric Respiratory Medicine, Nottingham University Hospitals NHS Trust, Nottingham, UK.

http://bit.ly/2webytn. Read More

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http://dx.doi.org/10.1183/20734735.0319-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249791PMC

Lung function evaluation in heart failure: possible pitfalls.

Breathe (Sheff) 2020 Mar;16(1):190316

Centro Cardiologico Monzino, IRCCS, Milan, Italy.

http://bit.ly/3aEy8ed. Read More

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http://dx.doi.org/10.1183/20734735.0316-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249789PMC

Screening for comorbidities in COPD.

Breathe (Sheff) 2020 Mar;16(1):190315

Dept of Respiratory and Sleep Medicine, Campbelltown Hospital, Sydney, Australia.

Due to growing recognition of comorbidities, COPD is no longer considered a disease affecting only the respiratory system. Its management now entails the early diagnosis and treatment of comorbidities. However, although many studies have examined the impact of comorbidities on the evolution of COPD and patients' quality of life, very few have explored the means to systematically identify and manage them. Read More

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http://dx.doi.org/10.1183/20734735.0315-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249790PMC

Assessment methods in respiratory medicine training in Europe: current status and future needs.

Authors:
Robert Primhak

Breathe (Sheff) 2020 Mar;16(1):190314

Education Council, European Respiratory Society, Lausanne, Switzerland.

There is a perceived need for harmonisation of training standards in medicine across Europe. Assessment methodology is a fundamental part of this harmonisation. Assessment may be: summative, measuring competency at the end of training, usually in a pass/fail mode; or formative, assessing strengths and weaknesses during training with a view to optimising performance. Read More

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http://dx.doi.org/10.1183/20734735.0314-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249786PMC

Summer schools of adult and paediatric respiratory medicine: course report.

Breathe (Sheff) 2020 Mar;16(1):190305

Division of Paediatric Pulmonology and Allergology, Dept of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria.

http://bit.ly/38VPAc5. Read More

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http://dx.doi.org/10.1183/20734735.0305-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249785PMC

Measuring inflammation in paediatric severe asthma: biomarkers in clinical practice.

Breathe (Sheff) 2020 Mar;16(1):190301

Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.

Severe asthma in children is a highly heterogeneous disorder, encompassing different clinical characteristics (phenotypes) and immunopathological pathways (endotypes). Research is focusing on the identification of noninvasive biomarkers able to predict treatment response and assist in designing personalised therapies for severe asthma. Blood and sputum eosinophils, serum IgE and exhaled nitric oxide fraction mostly reflect type 2 airway inflammation in children. Read More

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http://dx.doi.org/10.1183/20734735.0301-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249787PMC

Pleuritic chest pain in a young asylum seeker.

Breathe (Sheff) 2020 Mar;16(1):190294

East Lancashire Hospitals NHS Trust, Blackburn, UK.

http://bit.ly/2JRAk6H. Read More

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http://dx.doi.org/10.1183/20734735.0294-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249788PMC

An unusual spirometric shape that you must not forget.

Breathe (Sheff) 2020 Mar;16(1):190176

Pulmonary Division, District Health Center, Azienda Sanitaria Locale Bari, Conversano, Bari, Italy.

http://bit.ly/30iHRCp. Read More

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http://dx.doi.org/10.1183/20734735.0176-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7249784PMC

Local expression profiles of vitamin D-related genes in airways of COPD patients.

Respir Res 2020 Jun 3;21(1):137. Epub 2020 Jun 3.

Department CHROMETA, Laboratory of Respiratory diseases and Thoracic Surgery (BREATHE), KU Leuven, Leuven, Belgium.

Treatment of Chronic Obstructive Pulmonary Disease (COPD) is based on bronchodilation, with inhaled corticosteroids or azithromycin associated when frequent exacerbations occur. Despite the proven benefits of current treatment regimens, the need for new interventions in delineated subgroups remains. There is convincing evidence for oral vitamin D supplementation in reducing exacerbations in COPD patients severely deficient for circulating vitamin D. Read More

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http://dx.doi.org/10.1186/s12931-020-01405-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7268690PMC

Essential Role of Hemoglobin βCys93 in Cardiovascular Physiology.

Physiology (Bethesda) 2020 Jul;35(4):234-243

Institute for Transformative Molecular Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio.

The supply of oxygen to tissues is controlled by microcirculatory blood flow. One of the more surprising discoveries in cardiovascular physiology is the critical dependence of microcirculatory blood flow on a single conserved cysteine within the β-subunit (βCys93) of hemoglobin (Hb). βCys93 is the primary site of Hb -nitrosylation [i. Read More

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http://dx.doi.org/10.1152/physiol.00040.2019DOI Listing

Successful eradication improves outcomes after lung transplantation: a retrospective cohort analysis.

Eur Respir J 2020 May 29. Epub 2020 May 29.

Department of Respiratory Medicine, University Hospitals Leuven, Leuven, Belgium.

Background: Long-term survival after lung transplantation (LTx) is hampered by development of chronic lung allograft dysfunction (CLAD). is an established risk factor for CLAD. Therefore, we investigated the effect of eradication on CLAD-free and graft survival. Read More

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http://dx.doi.org/10.1183/13993003.01720-2020DOI Listing

Improving Global Newborn Survival: Building upon Helping Babies Breathe.

Authors:
Susan Niermeyer

Neonatology 2020 May 26:1-6. Epub 2020 May 26.

Section of Neonatology, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA,

Achieving the targets of the Every Newborn Action Plan by the year 2030 will require accelerating the current reduction in neonatal mortality. Educational programs addressing the three major causes of neonatal death - intrapartum-related events (asphyxia), prematurity and small size at birth, and infection - have the potential to significantly reduce preventable mortality. Helping Babies Breathe is an example of an educational program that not only has given health care providers around the world access to current resuscitation science but has changed provider behavior and patient outcomes and resulted in perinatal quality improvement in small- and large-scale trials. Read More

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http://dx.doi.org/10.1159/000507025DOI Listing

Physiological Basis of Neonatal Aerodigestive Difficulties in Chronic Lung Disease.

Clin Perinatol 2020 Jun 12;47(2):277-299. Epub 2020 Mar 12.

Neonatal Intensive Care Unit, Alberta Health Services, Cumming School of Medicine, Alberta Children's Hospital, 28 Oki Drive Northwest, Calgary, Alberta T3B 6A8, Canada.

In the United States, preterm birth rates have steadily increased since 2014. Despite the recent advances in neonatal-perinatal care, more than 40% of very low-birth-weight infants develop chronic lung disease (CLD) and almost 25% have feeding difficulties resulting in delayed achievement of full oral feeds and longer hospital stay. Establishment of full oral feeds, a major challenge for preterm infants, becomes magnified among those on respiratory support and/or with CLD. Read More

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http://dx.doi.org/10.1016/j.clp.2020.03.001DOI Listing

Analgesia of Patients with Multiple Rib Fractures in Critical Care: A Survey of Healthcare Professionals in the UK.

Indian J Crit Care Med 2020 Mar;24(3):184-189

Department of Anesthesia and Critical Care, Queen Elizabeth Hospital Birmingham, Birmingham, UK.

Introduction: Good analgesia has been shown to reduce the risk of pneumonia, chronic pain, and mortality in patients with multiple rib fractures (MRFs). This survey explores the current analgesic practice in the UK, protocol use, barriers to provision, and physician preferences.

Materials And Methods: A web-based survey was distributed nationally to an enriched cohort of clinicians working in UK trauma units with an interest in MRF management. Read More

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http://dx.doi.org/10.5005/jp-journals-10071-23375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225763PMC

Clean Water through Nanotechnology: Needs, Gaps, and Fulfillment.

ACS Nano 2020 Jun 11;14(6):6420-6435. Epub 2020 Jun 11.

Department of Chemistry, DST Unit of Nanoscience (DST UNS) and Thematic Unit of Excellence (TUE), Indian Institute of Technology Madras, Chennai 600036, India.

Sustainable nanotechnology has made substantial contributions in providing contaminant-free water to humanity. In this Review, we present the compelling need for providing access to clean water through nanotechnology-enabled solutions and the large disparities in ensuring their implementation. We also discuss the current nanotechnology frontiers in diverse areas of the clean water space with an emphasis on applications in the field and provide suggestions for future research. Read More

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http://dx.doi.org/10.1021/acsnano.9b01730DOI Listing

Permanent brain arrest as the sole criterion of death in systemic circulatory arrest.

Anaesthesia 2020 May 19. Epub 2020 May 19.

Department of Neurology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.

Historically, there has been a tendency to think that there are two types of death: circulatory and neurological. Holding onto this tendency is making it harder to navigate emerging resuscitative technologies, such as extracorporeal membrane oxygenation and the recent well-publicised experiment that demonstrated the possibility of restoring cellular function to some brain neurons 4 h after normothermic circulatory arrest (decapitation) in pigs. Attempts have been made to respond to these difficulties by proposing a unified brain-based criterion for human death, which we call 'permanent brain arrest'. Read More

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http://dx.doi.org/10.1111/anae.15050DOI Listing

AMPK and the Need to Breathe and Feed: What's the Matter with Oxygen?

Int J Mol Sci 2020 May 15;21(10). Epub 2020 May 15.

Division of Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, UK.

We live and to do so we must breathe and eat, so are we a combination of what we eat and breathe? Here, we will consider this question, and the role in this respect of the AMP-activated protein kinase (AMPK). Emerging evidence suggests that AMPK facilitates central and peripheral reflexes that coordinate breathing and oxygen supply, and contributes to the central regulation of feeding and food choice. We propose, therefore, that oxygen supply to the body is aligned with not only the quantity we eat, but also nutrient-based diet selection, and that the cell-specific expression pattern of AMPK subunit isoforms is critical to appropriate system alignment in this respect. Read More

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http://dx.doi.org/10.3390/ijms21103518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279029PMC

Non-coding RNAs in drug resistance of head and neck cancers: A review.

Biomed Pharmacother 2020 Jul 16;127:110231. Epub 2020 May 16.

Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, Shanxi Medical University, Taiyuan, 030001, Shanxi, PR China; Department of Otolaryngology Head & Neck Surgery, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, PR China; Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi, PR China; Key Laboratory of Cellular Physiology, Ministry of Education, Shanxi Medical University, Taiyuan, 030001, Shanxi, PR China; Yiducloud's Institute of Medical Data Science, Shanxi Medical University, Taiyuan, 030001, Shanxi, PR China. Electronic address:

Head and neck cancer (HNC), which includes epithelial malignancies of the upper aerodigestive tract (oral cavity, oropharynx, pharynx, hypopharynx, larynx, and thyroid), are slowly but consistently increasing, while the overall survival rate remains unsatisfactory. Because of the multifunctional anatomical intricacies of the head and neck, disease progression and therapy-related side effects often severely affect the patient's appearance and self-image, as well as their ability to breathe, speak, and swallow. Patients with HNC require a multidisciplinary approach involving surgery, radiation therapy, and chemotherapeutics. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110231DOI Listing

We all breathe the same air …. and we are all mortal.

Cardiovasc Res 2020 May 18. Epub 2020 May 18.

University/BHF Centre for Cardiovascular Sciences, University of Edinburgh, Edinburgh, Scotland, U.K.

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http://dx.doi.org/10.1093/cvr/cvaa126DOI Listing

Congenital arrhinia: A case report and literature review.

Int J Pediatr Otorhinolaryngol 2020 Aug 5;135:110083. Epub 2020 May 5.

Al-Quds University Faculty of Medicine, Jerusalem, Palestine. Electronic address:

Introduction: Underdevelopment of the nose is a wide spectrum entity ranges from partial absence of the nose to congenital arrhinia (CA). CA is the congenital absence of the external nose, nasal cavities, and/or nasal nostrils±olfactory apparatus, and is an extremely rare entity as less than 50 cases reported in the literature. CA can be isolated and idiopathic in origin or be a part of genetic-linked certain syndromes. Read More

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http://dx.doi.org/10.1016/j.ijporl.2020.110083DOI Listing

A Focus Group Evaluation of Breathe Easier: A Mindfulness-Based mHealth App for Survivors of Lung Cancer and Their Family Members.

Am J Health Promot 2020 May 14:890117120924176. Epub 2020 May 14.

College of Social Work, University of South Carolina, Columbia,SC, USA.

Purpose: To explore attitudes and acceptance (i.e., intent for future adoption) of survivors of lung cancer and their family members toward a dyad-focused mHealth mindfulness-based intervention (MBI). Read More

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http://dx.doi.org/10.1177/0890117120924176DOI Listing

'And breathe…'? The sociology of health and illness in COVID-19 time.

Authors:
Catherine M Will

Sociol Health Illn 2020 06 13;42(5):967-971. Epub 2020 May 13.

School of Law, Politics and Sociology, University of Sussex, Sussex, UK.

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http://dx.doi.org/10.1111/1467-9566.13110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273003PMC

A randomized-controlled trial of sugammadex versus neostigmine: impact on early postoperative strength.

Can J Anaesth 2020 May 13. Epub 2020 May 13.

Department of Anesthesiology, Stony Brook Medicine, Stony Brook, NY, 11794, USA.

Background: Residual neuromuscular blockade after surgery is associated with airway obstruction, hypoxia, and respiratory complications. Compared with neostigmine, sugammadex reverses neuromuscular blockade to a train-of-four ratio > 0.9 more rapidly. Read More

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http://dx.doi.org/10.1007/s12630-020-01695-4DOI Listing

Epidemiology of neonatal infections in hospitals of Nepal: evidence from a large- scale study.

Arch Public Health 2020 7;78:39. Epub 2020 May 7.

6Department of Women's and Children's Health, Uppsala University, Dag Hammarskjölds väg 14B, Uppsala, Sweden.

Background: Every year, neonatal infections account for approximately 750,000 neonatal deaths globally. It is the third major cause of neonatal death, globally and in Nepal. There is a paucity of data on clinical aetiology and outcomes of neonatal infection in Nepal. Read More

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http://dx.doi.org/10.1186/s13690-020-00424-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203977PMC

Not Crying After Birth as a Predictor of Not Breathing.

Pediatrics 2020 Jun 12;145(6). Epub 2020 May 12.

University of Calgary, Calgary, Canada.

Background: Worldwide, every year, 6 to 10 million infants require resuscitation at birth according to estimates based on limited data regarding "nonbreathing" infants. In this article, we aim to describe the incidence of "noncrying" and nonbreathing infants after birth, the need for basic resuscitation with bag-and-mask ventilation, and death before discharge.

Methods: We conducted an observational study of 19 977 infants in 4 hospitals in Nepal. Read More

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http://dx.doi.org/10.1542/peds.2019-2719DOI Listing

Thenar oxygen saturation (StO) alterations during a spontaneous breathing trial predict extubation failure.

Ann Intensive Care 2020 May 11;10(1):54. Epub 2020 May 11.

Critical Care Department, Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT), Parc Taulí, 1, 08208, Sabadell, Spain.

Background: Weaning from mechanical ventilation (MV) is a cardiovascular stress test. Monitoring the regional oxygenation status has shown promising results in predicting the tolerance to spontaneously breathe in the process of weaning from MV. Our aim was to determine whether changes in skeletal muscle oxygen saturation (StO) measured by near-infrared spectroscopy (NIRS) on the thenar eminence during a vascular occlusion test (VOT) can be used to predict extubation failure from mechanical ventilation. Read More

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http://dx.doi.org/10.1186/s13613-020-00670-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214564PMC

Severe Pulmonary Hypertension Management Across Europe (PHAROS): an ERS Clinical Research Collaboration.

Eur Respir J 2020 May 7;55(5). Epub 2020 May 7.

Clinical Dept of Respiratory Diseases, Pulmonary Hypertension Center, UZ Leuven, Leuven, Belgium.

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http://dx.doi.org/10.1183/13993003.01047-2020DOI Listing

Late-onset "acute fibrinous and organising pneumonia" impairs long-term lung allograft function and survival.

Eur Respir J 2020 May 7. Epub 2020 May 7.

Department of Chronic Diseases, Metabolism and Ageing, BREATHE, KU Leuven, Belgium

Background: Acute fibrinous and organising pneumonia (AFOP) after lung transplantation is associated with a rapid decline in pulmonary function. However, the relation with chronic lung allograft dysfunction (CLAD) remains unclear. We investigated the association between detection of AFOP in lung allograft biopsies with clinically important endpoints. Read More

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http://dx.doi.org/10.1183/13993003.02292-2019DOI Listing