510,592 results match your criteria Breast care Basel Switzerland[Journal]


Circulating myeloid-derived suppressor cells facilitate invasion of thyroid cancer cells by repressing miR-486-3p.

J Clin Endocrinol Metab 2020 Jun 3. Epub 2020 Jun 3.

Department of Endocrinology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Background: Myeloid-derived suppressor cells (MDSCs) have become increasingly recognized as facilitators of tumor development. However, the role of MDSCs in papillary thyroid carcinoma (PTC) progression has not been clearly explored.

Objective:: We aimed to evaluate the levels as well as function of circulating MDSCs in PTC. Read More

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http://dx.doi.org/10.1210/clinem/dgaa344DOI Listing

Community outreach and integration of breast radiologists.

Clin Imaging 2020 May 16;66:143-146. Epub 2020 May 16.

Department of Radiology, University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

With the increased emphasis on patient experience and shift toward patient- and family-centered care in health care, balancing the daily practice of radiology and devoting time to community outreach and engagement can seem challenging. We describe various methods of community outreach and integration attainable by breast imagers and how these can be used to develop relations with patients and providers, improve patient access, and inspire future breast imagers. Engagement in community outreach by the breast imager can positively impact breast radiologists, their radiology groups, and patients. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.05.011DOI Listing

FGFR4: A promising therapeutic target for breast cancer and other solid tumors.

Pharmacol Ther 2020 May 31:107590. Epub 2020 May 31.

Women's Cancer Research Center, UPMC Hillman Cancer Center, Pittsburgh, PA, USA; Magee-Women's Research Institute, Magee-Women's Research Hospital of University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

The fibroblast growth factor receptor (FGFR) signaling pathway has long been known to cancer researchers because of its role in cell survival, proliferation, migration, and angiogenesis. Dysregulation of FGFR signaling is frequently reported in cancer studies, but most of these studies focus on FGFR1-3. However, there is growing evidence implicating an important and unique role of FGFR4 in oncogenesis, tumor progression, and resistance to anti-tumor therapy in multiple types of cancer. Read More

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http://dx.doi.org/10.1016/j.pharmthera.2020.107590DOI Listing

Oroxylin A suppresses ACTN1 expression to inactivate cancer-associated fibroblasts and restrain breast cancer metastasis.

Pharmacol Res 2020 May 31:104981. Epub 2020 May 31.

State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, People's Republic of China. Electronic address:

Tumor initiation and progression are not only ascribed to the behavior of cancer cells, but also profoundly influenced by the tumor microenvironment. Inside, cancer-associated fibroblasts (CAFs) have become key factors to accelerate growth and metastasis for the abundance in most solid tumors. Our group previously reported that Oroxylin A (OA), a flavone from Scutellaria Baicalensis Georgi, possess the ability to suppress growth and invasion of several tumor cells. Read More

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http://dx.doi.org/10.1016/j.phrs.2020.104981DOI Listing

T-cell-Based Breast Cancer Immunotherapy.

Semin Cancer Biol 2020 May 31. Epub 2020 May 31.

Laboratory of Translational Immunology, Italy; Medical Oncology and Hematology Unit, Italy; Humanitas Clinical and Research Center - IRCCS - Rozzano, MI, Italy. Electronic address:

Cancer immunotherapy has witnessed a new renaissance with the advent of immune checkpoint inhibitors, which reactivate T cells and foster endogenous anti-tumor responses. The excellent results of immunotherapy in the field of melanoma, renal cancer, lung cancer, and other cancer types that have traditionally been known to be immunogenic, rekindled the interest of the oncology community in extending the benefits to all cancers including breast cancer (BC). In this review, we highlight the current state of using T cells as both markers for clinical practice and therapeutic options for BC. Read More

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http://dx.doi.org/10.1016/j.semcancer.2020.05.019DOI Listing

Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer.

Cell Rep 2020 Jun;31(9):107701

Department of Cancer Biology, Metastasis Research Center, University of Texas MD Anderson Cancer Center, Houston, TX 77054, USA; Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA; Department of Bioengineering, Rice University, Houston, TX 77030, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

The mechanistic contributions of cancer-associated fibroblasts (CAFs) in breast cancer progression remain to be fully understood. While altered glucose metabolism in CAFs could fuel cancer cells, how such metabolic reprogramming emerges and is sustained needs further investigation. Studying fibroblasts isolated from patients with benign breast tissues and breast cancer, in conjunction with multiple animal models, we demonstrate that CAFs exhibit a metabolic shift toward lactate and pyruvate production and fuel biosynthetic pathways of cancer cells. Read More

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http://dx.doi.org/10.1016/j.celrep.2020.107701DOI Listing

The Major Pre- and Postmenopausal Estrogens Play Opposing Roles in Obesity-Driven Mammary Inflammation and Breast Cancer Development.

Cell Metab 2020 Jun;31(6):1154-1172.e9

Braman Family Breast Cancer Institute, Sylvester Comprehensive Cancer Center, Miami, FL 33136, USA; Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA; Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL, USA. Electronic address:

Many inflammation-associated diseases, including cancers, increase in women after menopause and with obesity. In contrast to anti-inflammatory actions of 17β-estradiol, we find estrone, which dominates after menopause, is pro-inflammatory. In human mammary adipocytes, cytokine expression increases with obesity, menopause, and cancer. Read More

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http://dx.doi.org/10.1016/j.cmet.2020.05.008DOI Listing

Ribociclib plus Fulvestrant in Advanced Breast Cancer. Reply.

N Engl J Med 2020 Jun;382(23):e85

University of Liege, Liege, Belgium.

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http://dx.doi.org/10.1056/NEJMc2004229DOI Listing

Ribociclib plus Fulvestrant in Advanced Breast Cancer.

Authors:
Elif Hindié

N Engl J Med 2020 Jun;382(23):e85

Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France

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http://dx.doi.org/10.1056/NEJMc2004229DOI Listing

Splenohepatic sarcoidosis 12 years after breast cancer curative surgery: a diagnostic dilemma in imaging.

ANZ J Surg 2020 Jun 3. Epub 2020 Jun 3.

Department of Gastrointestinal Surgery, Kanta-Häme Central Hospital, Hämeenlinna, Finland.

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http://dx.doi.org/10.1111/ans.16017DOI Listing

Axillary nodal metastatic burden in patients with breast cancer with clinically positive axillary nodes.

Br J Surg 2020 Jun 3. Epub 2020 Jun 3.

Breast Surgery Unit, Comprehensive Cancer Center, Helsinki, Finland.

Background: The aim of this study was to determine preoperative factors and tumour characteristics related to a high nodal tumour burden in patients with clinically node-positive breast cancer. These findings were used to construct a predictive tool to evaluate the patient-specific risk of having more than two axillary lymph node metastases.

Methods: Altogether, 507 consecutive patients with breast cancer and axillary lymph node metastasis diagnosed by preoperative ultrasound-guided needle biopsy were reviewed. Read More

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http://dx.doi.org/10.1002/bjs.11653DOI Listing

Deimplementation of the Choosing Wisely Recommendations for Low-Value Breast Cancer Surgery: A Systematic Review.

JAMA Surg 2020 Jun 3. Epub 2020 Jun 3.

Department of Surgery, University of Michigan, Ann Arbor.

Importance: Overtreatment of early-stage breast cancer results in increased morbidity and cost without improving survival. Major surgical organizations participating in the Choosing Wisely campaign identified 4 breast cancer operations as low value: (1) axillary lymph node dissection for limited nodal disease in patients receiving lumpectomy and radiation, (2) re-excision for close but negative lumpectomy margins for invasive cancer, (3) contralateral prophylactic mastectomy in patients at average risk with unilateral cancer, and (4) sentinel lymph node biopsy in women 70 years or older with hormone receptor-positive cancer.

Objective: To evaluate the extent to which these procedures have been deimplemented, determine the implications of decreased use, and recognize possible barriers and facilitators to deimplementation. Read More

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http://dx.doi.org/10.1001/jamasurg.2020.0322DOI Listing

Absolute and relative reliability of pain sensitivity and functional outcomes of the affected shoulder among women with pain after breast cancer treatment.

PLoS One 2020 3;15(6):e0234118. Epub 2020 Jun 3.

Department of Health Science and Technology, Sport Sciences - Performance and Technology, Aalborg University, Aalborg, Denmark.

Objective: Breast cancer survivors (BCS) are often characterized by decreased pressure pain thresholds (PPT), range of motion (ROM) and strength in and around the shoulder affected by the treatment. This intra-rater reliability study was to establish the relative and absolute reliability of PPT's, active ROM and maximal isokinetic muscle strength (MIMS) of the affected shoulder in BCS with persistent pain after treatment.

Methods: Twenty-one BCS participated in the study. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234118PLOS

Hexokinase II-derived cell-penetrating peptide mediates delivery of microRNA mimic for cancer-selective cytotoxicity.

Biochemistry 2020 Jun 3. Epub 2020 Jun 3.

Cancer cells are often characterized by elevated levels of mitochondria-bound hexokinase II (HKII), which facilitates their survival, proliferation and metastasis. Here, we have designed a cancer-selective cell-penetrating peptide (CPP) by covalently coupling a short penetration accelerating sequence (PAS) to the mitochondrial membrane-binding N-terminal 15 amino acids of HKII (pHK). PAS-pHK mediates efficient cellular uptake and cytosolic delivery of a synthetic mimic of miR-126, a tumor suppressor miRNA downregulated in many malignancies. Read More

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http://dx.doi.org/10.1021/acs.biochem.0c00141DOI Listing

Harmonization of Quantitative Parenchymal Enhancement in T -Weighted Breast MRI.

J Magn Reson Imaging 2020 Jun 3. Epub 2020 Jun 3.

Image Sciences Institute, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Background: Differences in imaging parameters influence computer-extracted parenchymal enhancement measures from breast MRI.

Purpose: To investigate the effect of differences in dynamic contrast-enhanced MRI acquisition parameter settings on quantitative parenchymal enhancement of the breast, and to evaluate harmonization of contrast-enhancement values with respect to flip angle and repetition time.

Study Type: Retrospective. Read More

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http://dx.doi.org/10.1002/jmri.27244DOI Listing

Editorial for "Harmonization of Quantitative Parenchymal Enhancement in T1-Weighted Breast MRI".

Authors:
Lars J Grimm

J Magn Reson Imaging 2020 Jun 3. Epub 2020 Jun 3.

Department of Radiology, Duke University Medical Center, Durham, North Carolina, USA.

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http://dx.doi.org/10.1002/jmri.27211DOI Listing

The search for yellow fever virus vaccine in breast milk of inadvertently vaccinated women in Brazil.

Rev Inst Med Trop Sao Paulo 2020 29;62:e33. Epub 2020 May 29.

Centro de Vigilância Epidemiológica "Prof. Alexandre Vranjac", Coordenadoria de Controle de Doenças, Secretaria de Estado da Saúde, São Paulo, São Paulo, Brazil.

Eleven lactating women were inadvertently vaccinated with 17DD yellow fever vaccine in a small city of Sao Paulo State, Brazil. Their infants were being exclusively breast-fed and the breastfeeding was interrupted for 10 days. Serum and breastmilk were collected from the vaccinated mothers and tested for the presence of genomic RNA of the vaccine strain 8, 10 and 15 days after vaccination. Read More

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http://dx.doi.org/10.1590/s1678-9946202062033DOI Listing

Theory-based training to promote breast cancer screening among women with breast cancer worries: randomized controlled trial.

Sao Paulo Med J 2020 Mar 1;138(2):158-166. Epub 2020 Jun 1.

Department of Public Health, Faculty of Nursing, Inönü Üniversitesi, Malatya, Turkey.

Background: Breast cancer worries are important determinants in relation to behavior favoring breast cancer screening.

Objective: To determine the effect of theory-based training to promote breast cancer screening among women with high and low levels of breast cancer worries.

Design And Setting: Randomized controlled trial, conducted in two family health centers. Read More

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http://dx.doi.org/10.1590/1516-3180.2019.033430092019DOI Listing

Maternal intention to breastfeed, duration of breastfeeding and reasons for weaning: a cohort study, Pelotas, RS, Brazil, 2014.

Epidemiol Serv Saude 2020 6;29(1):e2019219. Epub 2020 Apr 6.

Programa de Pós-Graduação em Epidemiologia, Universidade Federal de Pelotas, Pelotas, RS, Brazil.

Objective: to evaluate maternal intention to breastfeed, duration of breastfeeding up to 24 months-of-age and reasons for weaning in the first year of life.

Methods: this was a cohort study conducted in Pelotas, RS, Brazil, with participants from the Multi-Center Body Composition Study; a life table was used to analyze duration of breastfeeding.

Results: of the 1377 mothers screened, 74. Read More

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http://dx.doi.org/10.5123/s1679-49742020000100024DOI Listing

ESP block compared to paravertebral block in breast surgery: a meta-analysis of randomized controlled trials.

Minerva Anestesiol 2020 Jun 2. Epub 2020 Jun 2.

Department of Anesthesiology and Reanimation, Ataturk University School of Medicine, Erzurum, Turkey.

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http://dx.doi.org/10.23736/S0375-9393.20.14630-3DOI Listing

Characteristics of early-onset pancreatic cancer and its association with familial pancreatic cancer and hereditary pancreatic cancer syndromes.

Ann Gastroenterol Surg 2020 May 27;4(3):229-233. Epub 2020 Mar 27.

Department of Gastroenterological Surgery Graduate School of Medicine Osaka University Osaka Japan.

The incidence of pancreatic cancer is high among those in their sixties to seventies but low in those in their fifties or younger. Although there is no unified definition regarding the age of early-onset pancreatic cancer, previously published reports suggest that, compared to later-onset pancreatic cancer patients, early-onset pancreatic cancer patients tend to be detected at advanced stages and thus have poor prognoses, but they do not show significantly higher rates of patients with genetic factors. On the other hand, it has been reported that patients with familial pancreatic cancer and hereditary pancreatic cancer syndromes often develop pancreatic cancer at a young age. Read More

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http://dx.doi.org/10.1002/ags3.12326DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240141PMC

The role of breath hold intensity modulated proton therapy for a case of left-sided breast cancer with IMN involvement. How protons compare with other conformal techniques?

Tech Innov Patient Support Radiat Oncol 2020 Sep 25;15:1-5. Epub 2020 May 25.

Health and Social Sciences Cluster, Singapore Institute of Technology, Singapore.

Purpose: To evaluate the dosimetric impact of four different radiotherapy techniques for a case of left-sided breast cancer with Internal Mammary lymph Nodes (IMN) involvement.

Materials And Methods: To identify the best radiotherapy technique for this patient, four methods were compared: 3D Conformal Radiotherapy (3D-CRT), Volumetric Modulated Arc Therapy (VMAT), Tomotherapy (TOMO) and Intensity Modulated Proton Therapy (IMPT). Patient was treated using deep inspiration breath-hold (DIBH) technique. Read More

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http://dx.doi.org/10.1016/j.tipsro.2020.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256639PMC
September 2020

Gene expression of Epithelial Membrane Protein 2 gene and β1-Integrin gene in patients with breast cancer.

Biochem Biophys Rep 2020 Jul 26;22:100708. Epub 2019 Nov 26.

Department of Chemistry, Faculty of Science, El Menoufia University, Shebin El-Kom, Egypt.

Background: Breast cancer is the most common invasive cancer and the leading cause of cancer death in women. The function of over a thousand genes is reported as affected by genetic modifications in breast cancer.

Objectives: To study the gene expression of Epithelial Membrane 2 (EMP2) and β1-Integrin genes in patients with breast cancer. Read More

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http://dx.doi.org/10.1016/j.bbrep.2019.100708DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261703PMC

Evaluation of breast screening strategies in a high risk breast and ovarian cancer clinic.

Gynecol Oncol Rep 2020 Aug 22;33:100587. Epub 2020 May 22.

University of Virginia Health System, Division of Gynecologic Oncology, United States.

Recent data suggest that BRCA mutation carriers younger than 40 may not benefit from mammography in addition to MRI. Our objective was to evaluate screening modalities utilized in a high-risk population. Clinicopathologic data were abstracted for patients followed in a high risk clinic from 2007 to 2017. Read More

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http://dx.doi.org/10.1016/j.gore.2020.100587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256456PMC

Concentric scaly rings in a patient with a history of breast cancer.

JAAD Case Rep 2020 Jun 22;6(6):503-505. Epub 2020 May 22.

Department of Dermatology, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

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http://dx.doi.org/10.1016/j.jdcr.2020.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256232PMC

Inhibitor of Interleukin-1 Receptor-associated Kinases 1/4, Can Increase the Sensitivity of Breast Cancer Cells to Methotrexate.

Int J Mol Cell Med 2019 ;8(3):200-209

Department of Clinical Biochemistry, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Breast cancer is the most common type of cancer among women. Chemotherapy is one of the main methods of breast cancer treatment, but this method is increasingly affected due to drug resistance. One of the newly discovered factors associated with drug resistance in cancer cells is interleukin receptor-associated kinase 1 (IRAK1). Read More

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http://dx.doi.org/10.22088/IJMCM.BUMS.8.3.200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241845PMC
January 2019

Assessment of myocardial extracellular volume on body computed tomography in breast cancer patients treated with anthracyclines.

Quant Imaging Med Surg 2020 May;10(5):934-944

Department of Biomedical Sciences for Health, Università degli Studi di Milano, Via Mangiagalli 31, 20133 Milan, Italy.

Background: Cancer treatment with anthracyclines may lead to an increased incidence of cardiac disease due to cardiotoxicity, as they may cause irreversible myocardial fibrosis. So far, the proposed methods for screening patients for cardiotoxicity have led to only limited success, while the analysis of myocardial extracellular volume (mECV) at cardiac magnetic resonance (CMR) has shown promising results, albeit requiring a dedicated exam. Recent studies have found strong correlations between mECV values obtained through computed tomography (CT), and those derived from CMR. Read More

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http://dx.doi.org/10.21037/qims.2020.04.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242290PMC

A method to establish a c-Myc transgenic mouse model of hepatocellular carcinoma.

MethodsX 2020 17;7:100921. Epub 2020 May 17.

State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, 651 Dongfeng East Road, Guangzhou 510060, China.

Hepatocellular carcinoma (HCC) remains one of the most lethal malignant cancers worldwide. HCC mouse models are widely used to explore the molecular pathogenesis of HCC and to test novel drug candidates. The advantages of this mouse model are as follows:•This method developed a H11 knock-in HCC mouse model by crossing H11 heterozygous mice with (albumin (Alb))-cre transgenic mice to generate c-Myc/Alb-cre double positive mice. Read More

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http://dx.doi.org/10.1016/j.mex.2020.100921DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256637PMC

Prevalence of Cancer in Rheumatoid Arthritis: Epidemiological Study Based on the National Health and Nutrition Examination Survey (NHANES).

Cureus 2020 Apr 28;12(4):e7870. Epub 2020 Apr 28.

Internal Medicine, University of Pittsburgh Medical Center (UPMC) Pinnacle, Lancaster, USA.

Rheumatoid arthritis (RA) is a multi-system autoimmune disease with significant morbidity and healthcare burden. It is an inflammatory condition and has been associated with lymphomas, with or without the presence of immunosuppressive therapy. However, the association of rheumatoid arthritis with other malignancies has been inconsistent. Read More

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http://dx.doi.org/10.7759/cureus.7870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255534PMC

Guizhi Fuling Decoction inhibiting the PI3K and MAPK pathways in breast cancer cells revealed by HTS technology and systems pharmacology.

Comput Struct Biotechnol J 2020 18;18:1121-1136. Epub 2020 May 18.

School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

As one of the classical traditional Chinese medicine (TCM) prescriptions in treating gynecological tumors, Guizhi Fuling Decoction (GFD) has been used to treat breast cancer (BRCA). Nonetheless, the potential molecular mechanism remains unclear so far. Therefore, systems pharmacology was used in combination with high throughput sequencing-based high throughput screening (HTS) assay and bioinformatic technologies in this study to investigate the molecular mechanisms of GFD in treating BRCA. Read More

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http://dx.doi.org/10.1016/j.csbj.2020.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260686PMC

The impact of pre-existed and SERM-induced non-alcoholic fatty liver disease on breast cancer survival: a meta-analysis.

J Cancer 2020 18;11(15):4597-4604. Epub 2020 May 18.

Department of Breast Surgery, Peking Union Medical College Hospital, Beijing, China.

: Non-alcoholic fatty liver disease (NAFLD) is a common disorder and a frequent side effect of endocrine therapy (ET) for breast cancer treatment. This was the first meta-analysis to investigate the impact of NAFLD on breast cancer survival. : We searched Pubmed, Embase and Cochrane Central Register of Controlled Trials database for relevant studies that investigated the correlation between NAFLD and breast cancer survival. Read More

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http://dx.doi.org/10.7150/jca.44872DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255364PMC

Efficacy and Safety of Thalidomide for Chemotherapy-induced Nausea and Vomiting.

J Cancer 2020 18;11(15):4560-4570. Epub 2020 May 18.

Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

: A substantial number of cancer patients discontinue chemotherapy due to severe chemotherapy-induced nausea and vomiting (CINV). This study aimed to evaluate the efficacy and safety of thalidomide (THD) in CINV. : We searched different databases to identify related studies that investigated the efficacy and safety of THD in CINV. Read More

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http://dx.doi.org/10.7150/jca.45678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255358PMC

The Power of Phytochemicals Combination in Cancer Chemoprevention.

J Cancer 2020 18;11(15):4521-4533. Epub 2020 May 18.

Department of Biological and Environmental Sciences, College of Arts and Sciences, Qatar University, Doha, Qatar.

Conventional therapies for cancer treatment have posed many challenges, including toxicity, multidrug resistance and economic expenses. In contrast, complementary alternative medicine (CAM), employing phytochemicals have recently received increased attention owing to their capability to modulate a myriad of molecular mechanisms with a less toxic effect. Increasing evidence from preclinical and clinical studies suggest that phytochemicals can favorably modulate several signaling pathways involved in cancer development and progression. Read More

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http://dx.doi.org/10.7150/jca.34374DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255361PMC

Angiogenesis in Breast Cancer Progression, Diagnosis, and Treatment.

J Cancer 2020 18;11(15):4474-4494. Epub 2020 May 18.

Department of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Memphis, TN 38163. USA.

Angiogenesis is a significant event in a wide range of healthy and diseased conditions. This process frequently involves vasodilation and an increase in vascular permeability. Numerous players referred to as angiogenic factors, work in tandem to facilitate the outgrowth of endothelial cells (EC) and the consequent vascularity. Read More

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http://dx.doi.org/10.7150/jca.44313DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255381PMC

DNA methylation profiling to predict overall survival risk in gastric cancer: development and validation of a nomogram to optimize clinical management.

J Cancer 2020 27;11(15):4352-4365. Epub 2020 Apr 27.

Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

DNA methylation has been reported to serve an important role in the carcinogenesis and development of gastric cancer. Our aim was to systematically develop an individualized prediction model of the survival risk combing clinical and methylation factors in gastric cancer. A univariate Cox proportional risk regression analysis was used to identify the prognosis-associated methylation sites based on the differentially expressed methylation sites between early and advanced gastric cancer group, then we applied least absolute shrinkage and selection operator (LASSO) Cox regression model to screen candidate methylation sites. Read More

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http://dx.doi.org/10.7150/jca.44436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255367PMC

Dynamic monitoring of CD45-/CD31+/DAPI+ circulating endothelial cells aneuploid for chromosome 8 during neoadjuvant chemotherapy in locally advanced breast cancer.

Ther Adv Med Oncol 2020 18;12:1758835920918470. Epub 2020 May 18.

Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, China.

Background: Neoadjuvant chemotherapy (NCT) is the standard treatment for patients with locally advanced breast cancer (LABC). The aim of this study was to verify this relationship, and to estimate the clinical value of aneuploid circulating endothelial cells (CECs) in LABC patients with different NCT responses.

Methods: Breast cancer patients received an EC4-T4 NCT regimen. Read More

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http://dx.doi.org/10.1177/1758835920918470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238307PMC

Identification of TUBB2A by quantitative proteomic analysis as a novel biomarker for the prediction of distant metastatic breast cancer.

Clin Proteomics 2020 24;17:16. Epub 2020 May 24.

Department of Biomedical Sciences, Seoul National University College of Medicine, 103 Daehakro, Seoul, 30380 Korea.

Background: Metastasis of breast cancer to distal organs is fatal. However, few studies have identified biomarkers that are associated with distant metastatic breast cancer. Furthermore, the inability of current biomarkers, such as HER2, ER, and PR, to differentiate between distant and nondistant metastatic breast cancers accurately has necessitated the development of novel biomarker candidates. Read More

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http://dx.doi.org/10.1186/s12014-020-09280-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247212PMC

Hybrid (2D/3D) Dosimetry of Radiolabeled Gold Nanoparticles for Sentinel Lymph Node Detection in Patients with Breast Cancer.

Contrast Media Mol Imaging 2020 6;2020:2728134. Epub 2020 May 6.

Departamento de Medicina Nuclear, Instituto Nacional de Cancerología, Ciudad de México 14000, Mexico.

Previously, we reported the preparation and preclinical studies of Tc-labeled gold nanoparticles-mannose (Tc-AuNP-mannose) with potential for sentinel lymph node (SLN) detection by using nuclear medicine procedures. This study aimed to evaluate the biokinetics and hybrid (2D/3D) dosimetry of Tc-AuNP-mannose in five patients with breast cancer under a sentinel lymph node detection protocol. Anterior and posterior whole-body planar images (2D, at 0. Read More

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http://dx.doi.org/10.1155/2020/2728134DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229544PMC

Nicotinamide N-methyltransferase inhibits autophagy induced by oxidative stress through suppressing the AMPK pathway in breast cancer cells.

Cancer Cell Int 2020 24;20:191. Epub 2020 May 24.

Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, 3 East Qingchun Road, Hangzhou, 310016 Zhejiang People's Republic of China.

Background: Nicotinamide N-methyltransferase (NNMT) is highly expressed in several cancers and can regulate cell epigenetic status and various cell metabolism pathways, such as ATP synthesis and cellular stress response. We reported in our previous papers that NNMT overexpression inhibits the apoptosis and enhances the chemotherapy resistance of breast cancer cells. This study aims to investigate the effect of NNMT on autophagy induced by oxidative stress in breast cancer cells, which might provide a novel therapeutic strategy for breast cancer treatment. Read More

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http://dx.doi.org/10.1186/s12935-020-01279-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247246PMC

Early diagnosis of breast and ovarian cancers by body fluids circulating tumor-derived exosomes.

Cancer Cell Int 2020 24;20:187. Epub 2020 May 24.

Department of Pathology, School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.

Exosomes (EXs) are small extracellular vesicles, a size range of 40-100 nm in diameter, actively secreted by most eukaryotic cells into surrounding body fluids like blood, saliva, urine, bile, breast milk and etc. These endosomal-derived vesicles mediate cell-cell communication between various cell populations through transmitting different signaling molecules such as lipids, proteins, and nucleic acids, and participate in a wide range of physiological and pathological body processes. Tumor-derived EXs (TDEs) are vehicles for intercellular communications by transferring bioactive molecules; they deliver oncogenic molecules and contain different molecular cargoes compared to EXs delivered from normal cells, therefore, they can be used as non-invasive invaluable biomarkers for early diagnosis and prognosis of most cancers, including breast and ovarian cancers. Read More

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http://dx.doi.org/10.1186/s12935-020-01276-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247259PMC

Prospective breast cancer risk factors prediction in Saudi women.

Saudi J Biol Sci 2020 Jun 2;27(6):1624-1631. Epub 2020 Mar 2.

King Abd Alla Medical Centre, Mecca, Saudi Arabia.

Women's health is affected by breast cancer worldwide and Saudi Arabia (SA) is no exception. Malignancy has enormous consequences for social, psychological and public health. The aim of this study was to examine the risk factors for Saudi women from breast cancer using logistic regression models. Read More

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http://dx.doi.org/10.1016/j.sjbs.2020.02.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7254039PMC
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