Changes in body composition and muscle attenuation during taxane-based chemotherapy in patients with metastatic breast cancer.
- Hánah N Rier,
- Agnes Jager,
- Stefan Sleijfer,
- Joost van Rosmalen,
- Marc C J M Kock,
- Mark-David Levin
Breast Cancer Res Treat 2017 Nov 17. Epub 2017 Nov 17.
Department of Internal Medicine, Albert Schweitzer Hospital, Albert Schweitzerplaats 25, 3318 AT, Dordrecht, The Netherlands.
Purpose: Body composition parameters including low muscle mass, muscle attenuation (which reflects muscle quality) and adipose tissue measurements have emerged as prognostic factors in cancer patients. However, knowledge regarding the possibility of excessive muscle loss during specific systemic therapies is unknown. We describe the changes in body composition and muscle attenuation (MA) during taxane- and anthracycline-based regimens and its association with overall survival (OS) in metastatic breast cancer patients. Read More